201. Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study
- Author
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Rik Vandenbergue, Lucia Farotti, Kaj Blennow, Jordi Clarimón, Philip Scheltens, Pablo Martinez-Lage, Frans R.J. Verhey, Babette L.R. Reijs, Juan Fortea, Pieter Jelle Visser, Henrik Zetterberg, Judes Poirier, Marcel M. Verbeek, Lucilla Parnetti, Magda Tsolaki, Lutz Frölich, Alberto Lleó, Mikel Tainta, Charlotte E. Teunissen, Daniel Alcolea, José Luis Molinuevo, Isabel Santana, Pedro Rosa-Neto, Anja Hviid Simonsen, Sylvain Lehmann, Yvonne Freund-Levi, Andrea Izaguirre, Rosalinde E.R. Slot, Neurology, Amsterdam Neuroscience - Neurodegeneration, Laboratory Medicine, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Promovendi MHN, Psychiatrie & Neuropsychologie, and MUMC+: MA Med Staf Spec Psychiatrie (9)
- Subjects
0301 basic medicine ,Male ,NATIONAL INSTITUTE ,Neurology ,Epidemiology ,PROTEIN ,Disease ,Gastroenterology ,RECOMMENDATIONS ,0302 clinical medicine ,Cerebrospinal fluid ,Neurofilament Proteins ,Longitudinal Studies ,Cognitive decline ,Phosphorylation ,Alzheimer ,Amyloid ,CSF ,Inflammation ,Neurofilaments ,Tau ,YKL-40 ,Health Policy ,DEMENTIA ,Middle Aged ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Psychiatry and Mental health ,Biomarker (medicine) ,Female ,ASSOCIATION WORKGROUPS ,medicine.medical_specialty ,Neurofilament light ,CSF BIOMARKERS ,BETA ,tau Proteins ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,All institutes and research themes of the Radboud University Medical Center ,Apolipoproteins E ,Developmental Neuroscience ,Alzheimer Disease ,Internal medicine ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Chitinase-3-Like Protein 1 ,Aged ,NEUROFILAMENT LIGHT ,Amyloid beta-Peptides ,business.industry ,medicine.disease ,Peptide Fragments ,030104 developmental biology ,TAU LEVELS ,Csf biomarkers ,DIAGNOSTIC GUIDELINES ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Introduction: Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods: We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow-up CSF levels of total tau (t-tau), phosphorylated tau (p-tau), YKL-40, and neurofilament light (NfL). Median CSF sampling interval was 2.1 years. Results: CSF levels of t-tau, p-tau, NfL, and YKL-40 were 2% higher per each year of baseline age in controls (P
- Published
- 2019