Epidermal cyst •Most common types of simple dermal epithelial lesions, showing well-encapsulated subepidermal mobile nodules •Arise in hair-bearing areas of the body, including the scalp, face, neck, trunk, and back •< 10%: extremities, palms, soles, breast •Filled with loose lamellae of keratin debris and bounded by stratified squamous epithelium, probably due to traumatic implantation of the epidermis into the dermis or subcutis •Mechanism: remnant ectodermal tissues misplaced during embryogenesis, occlusion of the pilosebaceous unit, or traumatic or surgical implantation of epithelial elements, human papillomavirus type 57 or 60 •Asymptomatic > infected or rupture if grow •If rupture, a secondary foreign body–type reaction, granulomatous reaction, or abscess formation may occur. •The radiological findings of epidermal cysts can be variable according to the compositions of the cysts. •US findings: circumscribed, hypoechoic, solid or complex-appearing masses •Purpose of this study: to evaluate US or CT findings of surgically proven epidermal cysts in the trunk. •63 patients with pathologically proved epidermal cysts of the trunk for 4 years •US: high frequency (12∼15 MHz) transducer •CT: pre- and postcontrast images with 5 mm slice thickness •US or CT findings: compared with surgical findings in regard to location, size, shape, number, echogenicity, posterior sound enhancement, septa, perilesional infiltration, calcifications and cystic wall enhancement. •All 63 patients (M:F=41:22; US in 36, CT in 27) had only one cyst. •Located in buttock (n=27), back (n=17), inguinal (n=6), posterior neck (n=5), perineum (n=3), abdominal wall (n=3), presternal (n=1), and axilla (n=1). •Mean size: 4.2 ´ 2.2 ´ 3.3 cm (range: 0.5∼13 cm) •Shape: oval (n=51), round (n=10), spindle (n=2) •US (n=36): - Homogeneously hypoechoic mass (n=11, 30.6%, Fig. 1) - Inhomogeneously hypoechoic mass (n=11, 30.6%) - Homogeneously hypoechoic mass with internal hypoechoic lines and echogenic spots (n=10, 27.8%, Fig. 2) - Homogeneously hypoechoic mass with internal echogenic spots (n=4, 11.1%) - Posterior sound enhancement (n=29, 80.6%) - On color Doppler study, no remarkably increased vascular flow in all cases with color Doppler study (n=28, Fig. 3). •CT (N=27): - Simple cyst (n=20, 74.1%) - Abscess-like lesion (n=7, 25.9%, Fig. 4) - Overlying skin thickening (n=18) - Contrast enhancement of cystic wall (n=15) - Perilesional infiltration (n=10) - Internal septa (n=8, Fig. 5) •All cysts were surgically well removed and internal contents of cysts were histologically keratinous (n=38, 60.3%, Fig. 1) or greasy (n=21, 33.3%, Fig. 2) materials. •Greasy materials mean the attenuated squamous epithelium with 'waxy' keratin in addition to usual layered keratin. •Variable echogenicity on US according to variable compositions - Type I: lesion with a simple lobulation - Type II: lesion with a protrusion - Type III: lesion with a focal wall perforation, a short neck, and a deep large protruding mass-like portion (abscess pocket formation). •For the inner contents of a complicated ganglion cyst or bursitis, anechoic fluid and echogenic debris are commonly noted and can move with compression by transducer. However, an epidermal cyst with moving debris is not seen and is not compressed. •Compared with neoplastic solid masses, ruptured epidermal cysts have multiple hyperechoic dot-like contents and can show increased color Doppler signals not in the inner contents but mainly in the wall or pericystic soft tissue. •Malignant degeneration of epidermal cysts is uncommon, but some reports of low-grade squamous cell carcinomas with incidence of 2.2% •Although epidermal cysts are generally solitary or few, patients with Gardner's syndrome may have multiple lesions, particularly on the face and scalp •The most important difference of contours between US findings of unruptured and ruptured epidermal cysts was not a lobulation but the combined protruding portions from epidermal cysts •Secondary change due to rupture or infection may make the preoperative diagnosis difficult, because the lesion mimics any other soft tissue mass. • Differential diagnosis: - abscesses, complicated ganglion cysts, complicated bursitis, neoplastic solid masses - synovial lesions, fibromas, xanthomas, lipomas, sacrococcygeal teratomas •Epidermal cysts showed homogeneous or inhomogeneous hypoechoic mass with posterior sound enhancement, variable echogenic spots, and no color Doppler signals on US. •In case of ruptured cyst, abscess-like lesion with wall enhancement, perilesional infiltration and lobulated contour was noted on CT scan. [ABSTRACT FROM AUTHOR]