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201. Exploratory Outlier Detection for Acceleromyographic Neuromuscular Monitoring: Machine Learning Approach (Preprint)

Author: Michaël Verdonck, Hugo Carvalho, Johan Berghmans, Patrice Forget, and Jan Poelaert
Abstract: BACKGROUND Because of their kinetic nature, artifactual recordings of acceleromyography-based neuromuscular monitoring devices are not unusual. These generate a great deal of cynicism among anesthesiologists, constituting an obstacle toward their widespread adoption. Through outlier analysis techniques, monitoring devices can learn to detect and flag signal abnormalities. OBJECTIVE This study aims to engineer a set of features that enable the detection of outliers in the form of erroneous train-of-four (TOF) measurements from an acceleromyographic-based device. These features are tested for their potential in the detection of erroneous TOF measurements by developing an outlier detection algorithm. METHODS A data set encompassing 533 high-sensitivity TOF measurements from 35 patients was created based on a multicentric open label trial of a purpose-built accelero- and gyroscopic-based neuromuscular monitoring app. A basic set of features was extracted based on raw data while a second set of features was purpose engineered based on TOF pattern characteristics. Two cost-sensitive logistic regression (CSLR) models were deployed to evaluate the performance of these features. The final output of the developed models was a binary classification, indicating if a TOF measurement was an outlier or not. RESULTS A total of 7 basic features were extracted based on raw data, while another 8 features were engineered based on TOF pattern characteristics. The model training and testing were based on separate data sets: one with 319 measurements (18 outliers) and a second with 214 measurements (12 outliers). The F1 score (95% CI) was 0.86 (0.48-0.97) for the CSLR model with engineered features, significantly larger than the CSLR model with the basic features (0.29 [0.17-0.53]; P CONCLUSIONS The set of engineered features and their corresponding incorporation in an outlier detection algorithm have the potential to increase overall neuromuscular monitoring data consistency. Integrating outlier flagging algorithms within neuromuscular monitors could potentially reduce overall acceleromyography-based reliability issues. CLINICALTRIAL ClinicalTrials.gov NCT03605225; https://clinicaltrials.gov/ct2/show/NCT03605225
Published: 2020
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202. Repetitive neuromuscular monitoring and stimulating electrode fatigue

Author: Lieselot Geerts, Panagiotis Flamée, Hugo Carvalho, Jan Poelaert, Michaël Verdonck, Faculty of Medicine and Pharmacy, Anesthesiology, Supporting clinical sciences, Basic (bio-) Medical Sciences, Medicine and Pharmacy academic/administration, and Anesthesiology research group
Subjects: Repetitive neuromuscular monitoring, medicine.medical_specialty, business.industry, Electromyography, Health Informatics, Critical Care and Intensive Care Medicine, Neuromuscular monitoring, surgery, Anesthesiology and Pain Medicine, Physical medicine and rehabilitation, stimulating electrode fatigue, Anesthesiology, Electrode, medicine, Humans, Neuromuscular Monitoring, business, Electrodes, Fatigue
Published: 2020

203. Elective surgery cancellations due to theCOVID-19 pandemic: global predictive modelling to inform surgical recovery plans

Author: Nepogodiev, D, Omar, Omar M, Glasbey, James C, Li, Elizabeth, Simoes, Joana FF, Abbott, Tom EF, Ademuyiwa, Adesoji O, Biccard, Bruce M, Chaudhry, Daoud, Davidson, Giana H, Di Saverio, Salomone, Gallo, Gaetano, Ghosh, Dhruv, Harrison, Ewen M, Hutchinson, Peter J, Kaafarani, Haytham MA, Kamarajah, Sivesh K, Keller, Deborah S, Lawani, Ismail, Minaya-Bravo, Ana, Moore, Rachel, Morton, Dion G, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert M, Ramos-De la Medina, Antonio, Tabiri, Stephen, Venn, Mary L, Bhangu, Aneel, Siaw-Acheampong, Kwabena, Adamina, Michel, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Alser, Osaid, Arnaud, Alexis P, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Benson, Ruth A, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Buarque, Igor Lima, Caruana, Edward J, Chakrabortee, Sohini, Cox, Daniel, Cunha, Miguel F, Dawson, Brett E, Desai, Anant, Drake, Thomas D, Edwards, John G, Elhadi, Muhammed, Evans, Jonathan P, Farik, Shebani, Fiore, Marco, Fitzgerald, J Edward, Ford, Samuel, Gomes, Gustavo Mendonca Ataide, Griffiths, Ewen A, Gujjuri, Rohan R, Halkias, Constantine, Heritage, Emily, Isik, Arda, Jenkinson, Michael D, Jones, Conor S, Khatri, Chetan, Keatley, James M, Kolias, Angelos, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Loffler, Markus W, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Mckay, Siobhan C, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Niquen, Milagros, Outani, Oumaima, Pellino, Gianluca, Pinkney, Thomas D, Pockney, Peter, Radenkovic, Dejan, Roberts, Keith, Roslani, April C, Santos, Irene, Schache, Andrew, Schnitzbauer, Andreas A, Stewart, Grant D, Shaw, Richard, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sundar, Sudha, Tiwari, Abhinav, Townend, Philip, Trout, Isobel M, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver, Wilkin, Richard JW, Wright, Naomi, Hoeft, Andreas, Rhodes, Andrew, Vallet, Benoit, Leva, Brigitte, Spies, Claudia, Vincent, Jean-Louis, Golder, Kim, Januszewska, Marta, Pelosi, Paolo, Bauer, Peter, Metnitz, Philipp, Moreno, Rui, Pearse, Rupert, Hewson, Russell, Damster, Sandrine, Ramos, Vasco, Hoste, Eric, Huyghens, Luc, Jacobs, Rita, Van Mossevelde, Veerle, Opdenacker, Godelieve, Poelaert, Jan, and Collaborative, COVIDsurg
Published: 2020

204. Neurophysiological Assessments During Continuous Sedation Until Death Put Validity of Observational Assessments Into Question: A Prospective Observational Study

Author: Stefaan, Six, Steven, Laureys, Jan, Poelaert, Olivier, Maîresse, Peter, Theuns, Johan, Bilsen, and Reginald, Deschepper
Abstract: In case of untreatable suffering at the end of life, continuous sedation until death (CSD) may be the only treatment option left. Because these patients cannot communicate anymore, caregivers have to rely on behavioral observation to assess the patient's comfort. Recently, however, a number of studies from the neurosciences have shown that sometimes consciousness and pain are undetectable with these traditional behavioral methods. The aim of this study was to find out if subjective caregiver assessments of consciousness and pain would be confirmed by objective neurophysiological measures.In this prospective observational study, we observed patients from the start of palliative sedation until death. Subjective caregiver assessments of level of consciousness and pain based on behavioral observations were compared with objective measures from neurophysiological monitoring devices.We collected and analyzed 108 subjective caregiver assessments in a sample of 12 patients and 32 assessments by traditionally used observational scales. We compared these with objective neurophysiological measures. Sensitivity and specificity of caregivers' subjective assessments of consciousness was 23.6 and 91.1% respectively, with an accuracy of 54.0% and interrater reliability (κ) of 0.13. For pain, this was 0 and 94.79%, respectively, an accuracy of 88%, and an inter-rater reliability (κ) of - 0.063. Agreement between caregivers' subjective assessments and objective neurophysiological measures of consciousness and pain was very poor.Caregivers' subjective assessment of level of consciousness and pain during CSD is unreliable compared with objective neurophysiological monitoring. Our results suggest that assessments of patient comfort during CSD could have been improved substantially by including objective monitoring of level of consciousness and pain.The protocol for this observational study has been registered retrospectively at Clinical-Trials.gov (ID NCT03273244).
Published: 2020

205. Risk Stratification in Patients undergoing Non-Operating Room Anaesthesia

Author: Nadia Najafi, Brecht Bockstael, Jan Poelaert, Anesthesiology, Faculty of Medicine and Pharmacy, Anesthesiology research group, and Supporting clinical sciences
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, Pneumonia, Viral, MEDLINE, Context (language use), 030204 cardiovascular system & hematology, anesthesia, Risk Assessment, NORA, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, 030202 anesthesiology, Multidisciplinary approach, Anesthesiology, Pandemic, medicine, Humans, Child, Pandemics, risk, room, business.industry, SARS-CoV-2, COVID-19, Anesthesiology and Pain Medicine, Anesthesia, Risk stratification, Airway management, Risk assessment, business, Coronavirus Infections
Abstract: Purpose of review A growing numerical and complexity of patients requiring nonoperating room anesthesia (NORA) necessitates a multidisciplinary approach of a highly experienced team in a highly technological setting of the cathlab or radiology suite. These requirements are even more magnified in the context of the coronavirus disease 2019 (COVID-19) pandemic. Recent findings This review describes the aspects of risk stratification both in adults and children with respect to patient morphology, airway management, cardiorespiratory function and finally future developments, which could beneficially interfere with imminent management in NORA. Moreover, some particular features related to COVID-19 are also discussed. Summary Apart from a thorough preoperative assessment, preventive strategies and well-chosen monitoring should be implemented to preclude inadvertent events in sometimes high-risk patients. Timely preventive measures and early recognition of complications could only be achieved by a multidisciplinary cooperating team. In addition, the implementation of safety measurements due to the infectious transmission to both the patients and care givers is crucial.
Published: 2020

206. An Alphaherpesvirus Exploits Antimicrobial β-Defensins To Initiate Respiratory Tract Infection

Author: Jolien Van Cleemput, Simon Daled, Nathalie Vanderheijden, Hans Nauwynck, Frank Pasmans, Maarten Dhaenens, Filip Boyen, Kathlyn Laval, and Katrien C. K. Poelaert
Subjects: beta-Defensins, viruses, Alphaherpesvirinae, BLOOD MONONUCLEAR-CELLS, beta-defensins, Anti-Infective Agents, Viral Envelope Proteins, Virion binding, THETA-DEFENSINS, Spotlight, Respiratory system, Respiratory Tract Infections, chemistry.chemical_classification, PEPTIDES, Herpesviridae Infections, medicine.anatomical_structure, Host-Pathogen Interactions, VIRUS, HERPESVIRUS-1, Rabbits, Equine herpesvirus, Herpesvirus 1, Equid, alphaherpesvirus, Immunology, INNATE, Biology, SEQUENCE, Microbiology, Virus, Theta defensin, Cell Line, Virology, equine herpesvirus, medicine, Animals, Horses, Veterinary Sciences, HUMAN ALPHA-DEFENSIN, Immune Evasion, immune evasion, β-defensins, HUMAN BETA-DEFENSIN-3, Epithelial Cells, respiratory tract, Beta defensin, chemistry, Insect Science, Pathogenesis and Immunity, Horse Diseases, GLYCOPROTEIN-M, Glycoprotein, Respiratory tract
Abstract: How herpesviruses circumvent mucosal defenses to promote infection of new hosts through the respiratory tract remains unknown due to a lack of host-specific model systems. We used the alphaherpesvirus equine herpesvirus type 1 (EHV1) and equine respiratory tissues to decipher this key event in general alphaherpesvirus pathogenesis. In contrast to several respiratory viruses and bacteria, EHV1 resisted potent antimicrobial equine β-defensins (eBDs) eBD2 and eBD3 by the action of glycoprotein M. Instead, eBD2 and -3 facilitated EHV1 particle aggregation and infection of rabbit kidney (RK13) cells. In addition, virion binding to and subsequent infection of respiratory epithelial cells were increased upon preincubation of these cells with eBD1, -2, and -3. Infected cells synthesized eBD2 and -3, promoting further host cell invasion by EHV1. Finally, eBD1, -2, and -3 recruited leukocytes, which are well-known EHV1 dissemination and latency vessels. The exploitation of host innate defenses by herpesviruses during the early phase of host colonization indicates that highly specialized strategies have developed during host-pathogen coevolution., β-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses. The lack of suitable respiratory model systems has precluded understanding of how herpesvirus virions overcome the abundant mucosal β-defensins during host invasion. We demonstrate how a central alphaherpesvirus, equine herpesvirus type 1 (EHV1), actually exploits β-defensins to invade its host and initiate viral spread. The equine β-defensins (eBDs) eBD1, -2, and -3 were produced and secreted along the upper respiratory tract. Despite the marked antimicrobial action of eBD2 and -3 against many bacterial and viral pathogens, EHV1 virions were resistant to eBDs through the action of the viral glycoprotein M envelope protein. Pretreatment of EHV1 virions with eBD2 and -3 increased the subsequent infection of rabbit kidney (RK13) cells, which was dependent on viral N-linked glycans. eBD2 and -3 also caused the aggregation of EHV1 virions on the cell surface of RK13 cells. Pretreatment of primary equine respiratory epithelial cells (EREC) with eBD1, -2, and -3 resulted in increased EHV1 virion binding to and infection of these cells. EHV1-infected EREC, in turn, showed an increased production of eBD2 and -3 compared to that seen in mock- and influenza virus-infected EREC. In addition, these eBDs attracted leukocytes, which are essential for EHV1 dissemination and which serve as latent infection reservoirs. These novel mechanisms provide new insights into herpesvirus respiratory tract infection and pathogenesis. IMPORTANCE How herpesviruses circumvent mucosal defenses to promote infection of new hosts through the respiratory tract remains unknown due to a lack of host-specific model systems. We used the alphaherpesvirus equine herpesvirus type 1 (EHV1) and equine respiratory tissues to decipher this key event in general alphaherpesvirus pathogenesis. In contrast to several respiratory viruses and bacteria, EHV1 resisted potent antimicrobial equine β-defensins (eBDs) eBD2 and eBD3 by the action of glycoprotein M. Instead, eBD2 and -3 facilitated EHV1 particle aggregation and infection of rabbit kidney (RK13) cells. In addition, virion binding to and subsequent infection of respiratory epithelial cells were increased upon preincubation of these cells with eBD1, -2, and -3. Infected cells synthesized eBD2 and -3, promoting further host cell invasion by EHV1. Finally, eBD1, -2, and -3 recruited leukocytes, which are well-known EHV1 dissemination and latency vessels. The exploitation of host innate defenses by herpesviruses during the early phase of host colonization indicates that highly specialized strategies have developed during host-pathogen coevolution.
Published: 2020
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207. A Reflection on Using Observational Measures for the Assessment and/or Monitoring of Level of Consciousness in Palliatively Sedated Patients

Author: Jan Poelaert, Steven Laureys, Johan Bilsen, Peter Theuns, Stefaan Six, Reginald Deschepper, Faculty of Medicine and Pharmacy, Public Health Sciences, Mental Health and Wellbeing research group, Anesthesiology research group, Supporting clinical sciences, Anesthesiology, Psychology, Brain, Body and Cognition, and End-of-life Care Research Group
Subjects: medicine.medical_specialty, Consciousness, business.industry, Palliative Care, MEDLINE, Conscious Sedation, Observation, General Medicine, Anesthesiology and Pain Medicine, Level of consciousness, Medicine, Humans, Hypnotics and Sedatives, Observational study, Medical physics, Reflection (computer graphics), business, General Nursing, Monitoring, Physiologic
Published: 2020

208. Additional file 1 of Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

Author: Hussain, Arif, Via, Gabriele, Melniker, Lawrence, Goffi, Alberto, Tavazzi, Guido, Neri, Luca, Villen, Tomas, Hoppmann, Richard, Mojoli, Francesco, Noble, Vicki, Zieleskiewicz, Laurent, Blanco, Pablo, Ma, Irene W. Y., Mahathar Abd. Wahab, Abdulmohsen Alsaawi, Salamah, Majid Al, Balik, Martin, Barca, Diego, Bendjelid, Karim, Belaid Bouhemad, Bravo-Figueroa, Pablo, Breitkreutz, Raoul, Calderon, Juan, Connolly, Jim, Copetti, Roberto, Corradi, Francesco, Dean, Anthony J., Denault, André, Govil, Deepak, Graci, Carmela, Young-Rock Ha, Hurtado, Laura, Kameda, Toru, Lanspa, Michael, Laursen, Christian B., Lee, Francis, Liu, Rachel, Meineri, Massimiliano, Montorfano, Miguel, Peiman Nazerian, Nelson, Bret P., Neskovic, Aleksandar N., Nogue, Ramon, Osman, Adi, Pazeli, José, Pereira-Junior, Elmo, Petrovic, Tomislav, Pivetta, Emanuele, Poelaert, Jan, Price, Susanna, Prosen, Gregor, Shalim Rodriguez, Rola, Philippe, Royse, Colin, Yale Tung Chen, Wells, Mike, Wong, Adrian, Xiaoting, Wang, Zhen, Wang, and Arabi, Yaseen
Subjects: Data_FILES, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract: Additonal file 1A. Panel Composition, Literature search
Published: 2020
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209. Additional file 9 of Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

Author: Hussain, Arif, Via, Gabriele, Melniker, Lawrence, Goffi, Alberto, Tavazzi, Guido, Neri, Luca, Villen, Tomas, Hoppmann, Richard, Mojoli, Francesco, Noble, Vicki, Zieleskiewicz, Laurent, Blanco, Pablo, Ma, Irene W. Y., Mahathar Abd. Wahab, Abdulmohsen Alsaawi, Salamah, Majid Al, Balik, Martin, Barca, Diego, Bendjelid, Karim, Belaid Bouhemad, Bravo-Figueroa, Pablo, Breitkreutz, Raoul, Calderon, Juan, Connolly, Jim, Copetti, Roberto, Corradi, Francesco, Dean, Anthony J., Denault, André, Govil, Deepak, Graci, Carmela, Young-Rock Ha, Hurtado, Laura, Kameda, Toru, Lanspa, Michael, Laursen, Christian B., Lee, Francis, Liu, Rachel, Meineri, Massimiliano, Montorfano, Miguel, Peiman Nazerian, Nelson, Bret P., Neskovic, Aleksandar N., Nogue, Ramon, Osman, Adi, Pazeli, José, Pereira-Junior, Elmo, Petrovic, Tomislav, Pivetta, Emanuele, Poelaert, Jan, Price, Susanna, Prosen, Gregor, Shalim Rodriguez, Rola, Philippe, Royse, Colin, Yale Tung Chen, Wells, Mike, Wong, Adrian, Xiaoting, Wang, Zhen, Wang, and Arabi, Yaseen
Abstract: Additional file 7. PoCUS-empowered triage in respiratory failure during COVID-19 Pandemic. Conceptual framework of point-of-care ultrasound (PoCUS) use for the triage of dyspneic and/or hypoxemic patients, during the SARS-CoV-2 pandemic: the diagram does not represent an algorithm but rather a framework for potentially developing protocols according to local/institutional clinical practices, policies and regulations. It does not either provide a list of conclusive diagnosis or specific treatments, but suggests how to integrate at best PoCUS in the workflow of this specific setting
Published: 2020
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210. Additional file 2 of Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

Author: Hussain, Arif, Via, Gabriele, Melniker, Lawrence, Goffi, Alberto, Tavazzi, Guido, Neri, Luca, Villen, Tomas, Hoppmann, Richard, Mojoli, Francesco, Noble, Vicki, Zieleskiewicz, Laurent, Blanco, Pablo, Ma, Irene W. Y., Mahathar Abd. Wahab, Abdulmohsen Alsaawi, Salamah, Majid Al, Balik, Martin, Barca, Diego, Bendjelid, Karim, Belaid Bouhemad, Bravo-Figueroa, Pablo, Breitkreutz, Raoul, Calderon, Juan, Connolly, Jim, Copetti, Roberto, Corradi, Francesco, Dean, Anthony J., Denault, André, Govil, Deepak, Graci, Carmela, Young-Rock Ha, Hurtado, Laura, Kameda, Toru, Lanspa, Michael, Laursen, Christian B., Lee, Francis, Liu, Rachel, Meineri, Massimiliano, Montorfano, Miguel, Peiman Nazerian, Nelson, Bret P., Neskovic, Aleksandar N., Nogue, Ramon, Osman, Adi, Pazeli, José, Pereira-Junior, Elmo, Petrovic, Tomislav, Pivetta, Emanuele, Poelaert, Jan, Price, Susanna, Prosen, Gregor, Shalim Rodriguez, Rola, Philippe, Royse, Colin, Yale Tung Chen, Wells, Mike, Wong, Adrian, Xiaoting, Wang, Zhen, Wang, and Arabi, Yaseen
Subjects: Data_FILES, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract: Additional file 1B. Consensus Methodology
Published: 2020
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211. Belgian standards for patient safety in anesthesia. Revision 2019 of the last version published in the Acta Anaesthesiologica Belgica, 2002, 53 (1) : 5-9

Author: Vincent Bonhomme, Patrick Wouters, Luc Foubert, Marc Van de Velde, Jean Francois Brichant, Stefan De Hert, Panayota Kapessidou, Annelies Moerman, Mona Momeni, Jan Poelaert, Steffen Rex, Vera Saldien, Michel Van Dyck, Luc Van Obbergh, Luc Sermeus, Stefaan Carlier, Eric Deflandre, Erika Slock, Guy Bergiers, Gilbert Bejjani, Rene Heylen, Dirk Himpe, Jan-Paul Muller, Anesthesiology research group, Supporting clinical sciences, and Anesthesiology
Published: 2020

212. Additional file 1 of Acceptance of mHealth among health professionals: a case study on anesthesia practitioners

Author: Carvalho, Hugo, Verdonck, Michael, Forget, Patrice, and Poelaert, Jan
Subjects: GeneralLiterature_INTRODUCTORYANDSURVEY, Data_FILES
Abstract: Additional file 1. Original survey used for the present study.
Published: 2020
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213. Additional file 3 of Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

Author: Hussain, Arif, Via, Gabriele, Melniker, Lawrence, Goffi, Alberto, Tavazzi, Guido, Neri, Luca, Villen, Tomas, Hoppmann, Richard, Mojoli, Francesco, Noble, Vicki, Zieleskiewicz, Laurent, Blanco, Pablo, Ma, Irene W. Y., Mahathar Abd. Wahab, Abdulmohsen Alsaawi, Salamah, Majid Al, Balik, Martin, Barca, Diego, Bendjelid, Karim, Belaid Bouhemad, Bravo-Figueroa, Pablo, Breitkreutz, Raoul, Calderon, Juan, Connolly, Jim, Copetti, Roberto, Corradi, Francesco, Dean, Anthony J., Denault, André, Govil, Deepak, Graci, Carmela, Young-Rock Ha, Hurtado, Laura, Kameda, Toru, Lanspa, Michael, Laursen, Christian B., Lee, Francis, Liu, Rachel, Meineri, Massimiliano, Montorfano, Miguel, Peiman Nazerian, Nelson, Bret P., Neskovic, Aleksandar N., Nogue, Ramon, Osman, Adi, Pazeli, José, Pereira-Junior, Elmo, Petrovic, Tomislav, Pivetta, Emanuele, Poelaert, Jan, Price, Susanna, Prosen, Gregor, Shalim Rodriguez, Rola, Philippe, Royse, Colin, Yale Tung Chen, Wells, Mike, Wong, Adrian, Xiaoting, Wang, Zhen, Wang, and Arabi, Yaseen
Abstract: Additional file 1C. Consensus Results and Summary Recommendations
Published: 2020
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214. Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging.

Author: Marleen Keyaerts, Isabel Remory, Vicky Caveliers, Karine Breckpot, Tomas J Bos, Jan Poelaert, Axel Bossuyt, and Tony Lahoutte
Subjects: Medicine, Science
Abstract: UNLABELLED: Bioluminescence imaging is routinely performed in anesthetized mice. Often isoflurane anesthesia is used because of its ease of use and fast induction/recovery. However, general anesthetics have been described as important inhibitors of the luciferase enzyme reaction. AIM: To investigate frequently used mouse anesthetics for their direct effect on the luciferase reaction, both in vitro and in vivo. MATERIALS AND METHODS: isoflurane, sevoflurane, desflurane, ketamine, xylazine, medetomidine, pentobarbital and avertin were tested in vitro on luciferase-expressing intact cells, and for non-volatile anesthetics on intact cells and cell lysates. In vivo, isoflurane was compared to unanesthetized animals and different anesthetics. Differences in maximal photon emission and time-to-peak photon emission were analyzed. RESULTS: All volatile anesthetics showed a clear inhibitory effect on the luciferase activity of 50% at physiological concentrations. Avertin had a stronger inhibitory effect of 80%. For ketamine and xylazine, increased photon emission was observed in intact cells, but this was not present in cell lysate assays, and was most likely due to cell toxicity and increased cell membrane permeability. In vivo, the highest signal intensities were measured in unanesthetized mice and pentobarbital anesthetized mice, followed by avertin. Isoflurane and ketamine/medetomidine anesthetized mice showed the lowest photon emission (40% of unanesthetized), with significantly longer time-to-peak than unanesthetized, pentobarbital or avertin-anesthetized mice. We conclude that, although strong inhibitory effects of anesthetics are present in vitro, their effect on in vivo BLI quantification is mainly due to their hemodynamic effects on mice and only to a lesser extent due to the direct inhibitory effect.
Published: 2012
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215. Development and validation of an android-based application for anaesthesia neuromuscular monitoring

Author: Johan Berghmans, Hugo Carvalho, Jan Poelaert, Michaël Verdonck, Faculty of Medicine and Pharmacy, Anesthesiology, Anesthesiology research group, and Supporting clinical sciences
Subjects: Male, medicine.medical_specialty, Health Informatics, Anesthesia, General, Critical Care and Intensive Care Medicine, Delayed Emergence from Anesthesia, Anaesthesia, User-Computer Interface, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology, Android, 030202 anesthesiology, Monitoring, Intraoperative, Accelerometry, medicine, Humans, Anesthesia, Clinical significance, General anaesthesia, Androstanols, Longitudinal Studies, Prospective Studies, Ulnar nerve, business.industry, Reproducibility of Results, 030208 emergency & critical care medicine, mobile application, Neuromuscular monitoring, Neuromuscular Blocking Agents, Mobile Applications, Anesthesiology and Pain Medicine, Concordance correlation coefficient, Neuromuscular Blockade, Female, Cellphone, Smartphone, APP, business, Elective Surgical Procedure, Neuromuscular Nondepolarizing Agents
Abstract: Quantitative neuromuscular block (NMB) assessment is an internationally recognised necessity in anesthesia care whenever neuromuscular blocking agents are administered. Despite this, the incidence of residual neuromuscular block and its associated major respiratory morbidity and mortality remain unacceptably high considering its preventable nature. Recent surveys show that quantitative NMB assessment is not consistently employed by anesthesiologists. Availability, price and practical concerns are some of the factors determining this phenomenon. Clinically assess and validate an Android cell phone application conceived specifically for NMB Monitoring in the anesthesia setting. Twenty-two adult ASA I to III patients scheduled to undergo elective surgical procedures under general anaesthesia requiring administration of a neuromuscular blocking agent were included. After anaesthesia induction, the grade of neuromuscular block was assessed at multiple independent time-points by paired comparison of the train of four (TOF) Ratios obtained by a Stimpod™ accelerometer and the currently developed application. Accelerometric measurements were made at the patient's hand after retrograde supramaximal stimulation of the ipsilateral ulnar nerve. TOF-ratios were subjected to bias analysis with 0.001 as the a priori established clinical significance cut-off. The difference between the two methods averaged 0.0004 (95% limits of agreement: ± 0.12), with 83.3% of the differences being under 0.05. This average inter-method difference was not significantly different than the a priori hypothesized difference cut-off of 0.001 (p = 0.78). Lin's concordance correlation coefficient and Pearson's correlation were both of 0.98. The custom developed Android application proved accurate for diagnosis of residual neuromuscular block.
Published: 2018
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216. Cardiac ultrasound: a true haemodynamic monitor?

Author: Jan Poelaert, Manu L N G Malbrain, Anesthesiology research group, and Supporting clinical sciences
Subjects: medicine.medical_specialty, Cardiac output, Stethoscope, Systole, Image quality, Afterload, Hemodynamics, Critical Care and Intensive Care Medicine, contractility, Cardiac Ultrasound, law.invention, cardiac ultrasound, symbols.namesake, law, Internal medicine, medicine, echocardiography, Humans, Ventricular Function, business.industry, cardiac output, General Medicine, Echocardiography, Doppler, Preload, Anesthesiology and Pain Medicine, preload, cardiovascular system, Cardiology, symbols, Vascular Resistance, business, Doppler effect
Abstract: Cardiac ultrasound has been used in the critically ill for more than thirty years. The technology has made enormous progression with respect to image quality and quantity, various Doppler techniques, as well as connectivity, the transfer of data and offline calculations. Some consider cardiac ultrasound as the stethoscope of the Twenty-first century. The potential of eye-balling moving cardiac structures gives undeniable power to this diagnostic and monitoring tool. The main shortcoming is the discontinuous mode of monitoring and the fact that optimal information acquisition can only be obtained when one is well-trained and experienced. Cardiac ultrasound has become an indispensable tool, especially in haemodynamically unstable patients. This review summarizes some important aspects of cardiac ultrasound with use of Doppler monitoring for assessment of the three most important pillars of haemodynamics, namely cardiac preload, afterload and contractile function.
Published: 2018
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217. Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

Author: Hussain, A, Via, G, Melniker, L, Goffi, A, Tavazzi, G, Neri, L, Villen, T, Hoppmann, R, Mojoli, F, Noble, V, Zieleskiewicz, L, Blanco, P, Ma, IWY, Abd Wahab, M, Alsaawi, A, Al Salamah, M, Balik, M, Barca, D, Bendjelid, K, Bouhemad, B, Bravo-Figueroa, P, Breitkreutz, R, Calderon, J, Connolly, J, Copetti, R, Corradi, F, Dean, AJ, Denault, A, Govil, D, Graci, C, Ha, Y-R, Hurtado, L, Kameda, T, Lanspa, M, Laursen, CB, Lee, F, Liu, R, Meineri, M, Montorfano, M, Nazerian, P, Nelson, BP, Neskovic, AN, Nogue, R, Osman, A, Pazeli, J, Pereira-Junior, E, Petrovic, T, Pivetta, E, Poelaert, J, Price, S, Prosen, G, Rodriguez, S, Rola, P, Royse, C, Chen, YT, Wells, M, Wong, A, Xiaoting, W, Zhen, W, Arabi, Y, Hussain, A, Via, G, Melniker, L, Goffi, A, Tavazzi, G, Neri, L, Villen, T, Hoppmann, R, Mojoli, F, Noble, V, Zieleskiewicz, L, Blanco, P, Ma, IWY, Abd Wahab, M, Alsaawi, A, Al Salamah, M, Balik, M, Barca, D, Bendjelid, K, Bouhemad, B, Bravo-Figueroa, P, Breitkreutz, R, Calderon, J, Connolly, J, Copetti, R, Corradi, F, Dean, AJ, Denault, A, Govil, D, Graci, C, Ha, Y-R, Hurtado, L, Kameda, T, Lanspa, M, Laursen, CB, Lee, F, Liu, R, Meineri, M, Montorfano, M, Nazerian, P, Nelson, BP, Neskovic, AN, Nogue, R, Osman, A, Pazeli, J, Pereira-Junior, E, Petrovic, T, Pivetta, E, Poelaert, J, Price, S, Prosen, G, Rodriguez, S, Rola, P, Royse, C, Chen, YT, Wells, M, Wong, A, Xiaoting, W, Zhen, W, and Arabi, Y
Abstract: COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 countries and 6 continents with considerable experience of direct application of PoCUS on COVID-19 patients presents evidence-based consensus using GRADE methodology for the quality of evidence and an expedited, modified-Delphi process for the strength of expert consensus. The use of ultrasound is suggested in many clinical situations related to respiratory, cardiovascular and thromboembolic aspects of COVID-19, comparing well with other imaging modalities. The limitations due to insufficient data are highlighted as opportunities for future research.
Published: 2020

218. When residents work less, they feel better: Lessons learned from an unprecedent context of lockdown.

Author: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service d'urologie, Degraeve, Amandine, Lejeune, Sibille, Muilwijk, Tim, Poelaert, Filip, Piraprez, Madeline, Svistakov, Ilyas, Roumeguère, Thierry, European Society of Residents in Urology Belgium (ESRU-B), UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service d'urologie, Degraeve, Amandine, Lejeune, Sibille, Muilwijk, Tim, Poelaert, Filip, Piraprez, Madeline, Svistakov, Ilyas, Roumeguère, Thierry, and European Society of Residents in Urology Belgium (ESRU-B)
Abstract: INTRODUCTION: With the COVID-19 outbreak activities of urology departments have been limited to non-deferrable procedures impacting the daily program of residents in urology. We assessed the psychological impact of the lockdown on Belgian residents in urology and their resounding on the quality of the training. MATERIAL AND METHODS: A self-administered anonymous questionnaire assessing the risk of burnout in a pandemic situation and its impact on the quality of the training was e-mailed to the members of the European Society of Residents in Urology of Belgium (ESRU-B). We used the Copenhagen Burnout Inventory score which assesses the different dimensions of burnout (personal (CBIP), professional (CBIPro), relational (CBIR)). Several questions evaluating impact on residents' health and apprehension of the future were included. The survey lasted for 5 days. Comparison of parameters before and during the coronavirus crisis was made using paired samples t-test or Chi2 test were. RESULTS: Fifty percent (62/126) of the ESRU-B members replied to the questionnaire. If 93% of the responders reported a negative impact on the quality of their practical training (CI95=[0.07-1.10]; P=0.83), 56% and 61.7% reported a positive impact of the crisis on their life and on their theoretical training respectively. Burnout risk scores were significantly reduced (P<0.001) for each dimension 7.26 to 3.40 (CBIP), 9.02 to 4.35 (CBIPro) and 4.42 to 3.03 (CBIR) respectively. CONCLUSION: Despite a negative impact on the daily work quality, the decrease in activity induced by the lockdown did not have a negative psychological impact on Belgian residents in urology but stress the opportunity to review the current training system to be better balanced between practice and theoretical formation., [Lorsque les internes travaillent moins, ils se sentent mieux: leçons tirées d'un contexte de confinement sans précédent] INTRODUCTION: Avec l’épidémie de COVID-19, les activités des services d’urologie se sont limitées à des procédures non différables, ayant un impact sur le programme quotidien des internes en urologie. Nous avons évalué l’impact psychologique du confinement sur les internes belges en urologie et son retentissement sur la qualité de la formation. MATÉRIEL ET MÉTHODES: Un questionnaire anonyme évaluant le risque d’épuisement professionnel en situation de pandémie et son impact sur la qualité de la formation a été envoyé par courrier électronique aux membres de la Société européenne des résidents en urologie de Belgique (ESRU-B). Nous avons utilisé le score Copenhagen Burnout Inventory qui évalue les différentes dimensions du burnout (personnel (CBIP), professionnel (CBIPro), relationnel (CBIR)). Plusieurs questions évaluant l’impact sur la santé des internes et leur appréhension de l’avenir ont été incluses. L’enquête a duré 5 jours. La comparaison des paramètres avant et pendant la crise du coronavirus a été effectuée à l’aide d’échantillons appariés test t ou test Chi2. RÉSULTATS: Cinquante pour cent (62/126) des membres de l’ESRU-B ont répondu au questionnaire. Si 93 % des répondants ont signalé un impact négatif sur la qualité de leur formation pratique (IC 95 % = [0,07–1,10]; p = 0,83), 56 % et 61,7 % ont rapporté un impact positif de la crise sur leur vie et sur leur formation. Les scores de risque de burnout ont été significativement réduits (p < 0,001) pour chaque dimension 7,26 à 3,40 (CBIP), 9,02 à 4,35 (CBIPro) et 4,42 à 3,03 (CBIR) respectivement. CONCLUSION: Malgré un retentissement négatif sur la qualité du travail au quotidien, la diminution d’activité induite par le confinement n’a pas eu d’impact psychologique négatif sur les internes belges en urologie. Cela souligne la possibilité de revoir le système de formation actuel pour tend
Published: 2020

219. Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men

Author: Marie-Astrid Denys, Karel Everaert, Edward Lambert, Nicolaas Lumen, and Filip Poelaert
Subjects: Adult, Male, medicine.medical_specialty, Test group, Urethral stricture, Urology, Prostatic Hyperplasia, 030232 urology & nephrology, Disease, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Urethral Stricture, Receiver operating characteristic, business.industry, Area under the curve, Middle Aged, medicine.disease, The primary diagnosis, Urodynamics, Logistic Models, ROC Curve, 030220 oncology & carcinogenesis, Prostatic obstruction, Rheology, business
Abstract: Objectives: To define a uroflowmetry-based non-invasive predictive tool for the primary diagnosis of urethral stricture disease. Methods: A total of 300 male patients (150 with urethral stricture disease and 150 with benign prostatic obstruction), treated surgically between 2005 and 2015, and 75 healthy males were included in this study. Patients were randomly assigned to one of two groups (75 benign prostatic obstruction patients and 75 urethral stricture disease patients in each group). A model, able to objectively differentiate between benign prostatic obstruction and urethral stricture disease, was created by use of original and hybrid uroflowmetry variables in logistic regression in groupA (test group). Receiver operating characteristics curve analysis was used for validation in groupB (validation group) and to calculate cut-off values to distinguish healthy individuals from benign prostatic obstruction as a result of urethral stricture disease. Results: Receiver operating characteristics area under the curve values of the created model were 0.841 (0.777-0.905) and 0.807 (0.735-0.879) in groups A and B, respectively. Optimal cut-off values were 2.2847 and 0.1182 to distinguish healthy individuals versus benign prostatic obstruction and benign prostatic obstruction versus urethral stricture disease. Conclusions: A triphasic uroflowmetry-based model is able to objectively distinguish voiding patterns of healthy individuals, benign prostatic obstruction and urethral stricture disease. The probability of urethral stricture disease can be objectively calculated for each individual patient based on a non-invasive uroflowmetry test. Uroflowmetry pattern interpretation by use of statistical models could become a new standard.
Published: 2018
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220. Protein value of two insects, subjected to various heat treatments, using growing rats and the protein digestibility-corrected amino acid score

Author: B. Crahay, Christine Poelaert, R. Caparros Megido, Jérôme Bindelle, Taofic Alabi, Yves Beckers, and Frédéric Francis
Subjects: 0301 basic medicine, Entomophagy, Larva, 030109 nutrition & dietetics, Food availability, media_common.quotation_subject, fungi, 04 agricultural and veterinary sciences, Insect, Biology, biology.organism_classification, 040401 food science, 03 medical and health sciences, 0404 agricultural biotechnology, Acheta, Insect Science, Protein digestibility, Amino acid score, Bioassay, Food science, Food Science, media_common
Abstract: To address the future challenge of food availability (9 billion people on earth by 2050), non-common sources of proteins need to be investigated. Insects are consumed mainly in Africa, Asia and South America, but entomophagy is now being increasingly promoted in Europe and North America. In addition to consumption in raw form, insects are often cooked, which represents an important guarantee for sanitation purposes. Little information is available on the influence of such treatment and its effect on the nutritional value of the resulting insect food. The aim of this study was to determine, depending on the heat treatment, the quality of the proteins of two edible insects, using the protein digestibility-corrected amino acid score (PDCAAS) and a rat bioassay. The insects were adult house crickets (Acheta domesticus) and the larvae of mealworms (Tenebrio molitor). Both insects, not heated or heat-treated by oven-cooking at 150 °C for 30 min or at 200 °C for 10 min and by autoclaving at 120 °C for 25 min, were fed to rats and evaluated for ingestion, digestibility and nitrogen retention and compared with a control casein diet. The growth performance of rats fed mealworm larvae, and to a lesser extent house crickets, was hampered by a deficiency in sulphur-containing amino acids (AA) in not heated insects. Then, the nitrogen retention of diets formulated with oven-cooked or autoclaved insects was reduced in rats because the AA profile was negatively modified by the heat treatment. Cooking insects at 200 °C for 10 min seemed the most appropriate for maintaining a high nutritive value in growing rats. However both tested insect-species are promising as human food ingredients because of (1) their high protein digestibility in the not heated state (84-92%) as well as after being heated (84-90%); and (2) their AA profile, which meets human dietary requirements (69-84% for PDCAAS).
Published: 2018
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221. Pelvic lymph node dissection in prostate cancer staging: evaluation of morbidity and oncological outcomes

Author: Nicolaas Lumen, Karel Decaestecker, Piet Ost, Andries Van Huele, Valérie Fonteyne, and Filip Poelaert
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Pelvis, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, mental disorders, medicine, Humans, Minimally Invasive Surgical Procedures, Lymph node, Survival analysis, Aged, Neoplasm Staging, Retrospective Studies, Surgical approach, business.industry, Prostatic Neoplasms, General Medicine, Middle Aged, Prognosis, medicine.disease, Radiation therapy, Dissection, Treatment Outcome, medicine.anatomical_structure, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Lymph Node Excision, 030211 gastroenterology & hepatology, Surgery, Lymph Nodes, Radiology, Prostate cancer staging, business
Abstract: To evaluate the morbidity of different surgical approaches for pelvic lymph node dissection (PLND), to evaluate the influence of morbidity on radiotherapy (RT) planning and to evaluate a possible therapeutic effect of a more extensive yield of PLND.From 2000-2016, 228 patients received staging PLND before primary RT in a single tertiary care center. Nine patients were excluded for the evaluation of morbidity. Fifty patients were operated in an open approach, 96 laparoscopic and 73 robot-assisted (RA). Clavien-Dindo classification was used for evaluating complications. Predictors of biochemical recurrence (BCR), clinical relapse (CR), cancer-specific survival (CSS) and overall survival (OS) were evaluated by regression analyses to determine a possible therapeutic effect.Minimal invasive surgery (laparoscopic or RA) caused five times less major complications (22% vs. 4.3%, p = .001) and a median 3 days shorter hospital stay (5 days versus 2 days, p .001). Major complications resulted in a delayed (23 days, p .001) RT start but no oncological effect was seen. Independent oncological predictors were the number of positive nodes (BCR, CR, CSS, OS), a lower age (CR), a higher level of initial prostate-specific antigen (PSA) (BCR) and post-RT PSA (BCR).Minimal invasive surgery can diminish major complications which delay RT start. Nodal staging proved to be of importance for prognosis but no therapeutic effect was seen of performing PLND as such.
Published: 2018
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222. A review of recommendations for rotavirus vaccination in Europe: Arguments for change

Author: Priya Pereira, Robert C. Gardner, Bernd Benninghoff, Dirk Poelaert, and Baudouin Standaert
Subjects: Rotavirus, 0301 basic medicine, National government, Cost-Benefit Analysis, 030106 microbiology, Rotavirus vaccination, medicine.disease_cause, Rotavirus Infections, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Health care, medicine, Humans, 030212 general & internal medicine, Health policy, Government, General Veterinary, General Immunology and Microbiology, business.industry, Vaccination, Rotavirus Vaccines, Public Health, Environmental and Occupational Health, Rotavirus vaccine, Europe, Infectious Diseases, Molecular Medicine, business
Abstract: Background More than 10 years after the authorisation of two rotavirus vaccines of demonstrated efficacy and with a strongly positive benefit-risk profile, uptake in Europe remains low. Only 13 countries in Europe provide a fully-funded rotavirus universal mass vaccination (UMV) programme, three provide a partially-funded programme, and one provides full funding for a reduced programme targeting at-risk infants. Around 40% of countries in Europe currently have no existing recommendations for rotavirus vaccine use in children from the national government. Methods We provide an overview of the status of rotavirus vaccine recommendations across Europe and the factors impeding uptake. We consider the evidence for the benefits and risks of vaccination, and argue that cost-effectiveness and cost-saving benefits justify greater access to rotavirus vaccines for infants living in Europe. Results Lack of awareness of the direct and indirect burden caused by rotavirus disease, potential cost-saving from rotavirus vaccination including considerable benefits to children, families and society, and government/insurer cost constraints all contribute to complacency at different levels of health policy in individual countries. Conclusions More than 10 years after their introduction, available data confirm the benefits and acceptable safety profile of infant rotavirus UMV programmes. Europe serves to gain considerably from rotavirus UMV in terms of reductions in healthcare resource utilization and related costs in both vaccinated subjects and their unvaccinated siblings through herd protection.
Published: 2018
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223. The effect of surgical experience on perioperative and oncological outcomes after robot-assisted radical cystectomy with intracorporeal urinary diversion: Evidence from a high-volume center

Author: F. D'hondt, Alessandro Larcher, Filip Poelaert, Alexandre Mottrie, M. Goossens, G. De Naeyer, Peter Schatteman, J. Vollemaere, Pieter Uvin, Justin W. Collins, Elio Mazzone, J. Van Der Jeugt, Edward Lambert, P. Dell’Oglio, and G. De Vos
Subjects: Cystectomy, medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, Urinary diversion, medicine, Center (algebra and category theory), Perioperative, business, Surgery, Volume (compression)
Published: 2019
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224. Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer

Author: Poelaert, Brittany J., primary, Knoche, Shelby M., additional, Larson, Alaina C., additional, Pandey, Poomy, additional, Seshacharyulu, Parthasarathy, additional, Khan, Nuzhat, additional, Maurer, H. Carlo, additional, Olive, Kenneth P., additional, Sheinin, Yuri, additional, Ahmad, Rizwan, additional, Singh, Amar B., additional, Batra, Surinder K., additional, Rachagani, Satyanarayana, additional, and Solheim, Joyce C., additional
Published: 2021
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225. The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1

Author: Laval, Kathlyn, primary, Poelaert, Katrien C. K., additional, Van Cleemput, Jolien, additional, Zhao, Jing, additional, Vandekerckhove, Annelies P., additional, Gryspeerdt, Annick C., additional, Garré, Barbara, additional, van der Meulen, Karen, additional, Baghi, Hossein B., additional, Dubale, Haileleul N., additional, Zarak, Ines, additional, Van Crombrugge, Eline, additional, and Nauwynck, Hans J., additional
Published: 2021
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226. The Effect of Surgical Experience on Perioperative and Oncological Outcomes After Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Evidence from a Referral Centre with Extensive Experience in Robotic Surgery

Author: Dell’Oglio, Paolo, primary, Mazzone, Elio, additional, Lambert, Edward, additional, Vollemaere, Jonathan, additional, Goossens, Marijn, additional, Larcher, Alessandro, additional, Van Der Jeugt, Jolien, additional, Devos, Gaetan, additional, Poelaert, Filip, additional, Uvin, Pieter, additional, Collins, Justin, additional, De Naeyer, Geert, additional, Schatteman, Peter, additional, D’Hondt, Frederiek, additional, and Mottrie, Alexandre, additional
Published: 2021
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227. Time to Move On: The Impending Need for a New Disease-specific Comorbidity Index for Bladder Cancer Patients Undergoing Robot-assisted Radical Cystectomy

Author: Lambert, Edward, primary, D’Hondt, Frederiek, additional, Mazzone, Elio, additional, Vollemaere, Jonathan, additional, Larcher, Alessandro, additional, Van Der Jeugt, Jolien, additional, Devos, Gaetan, additional, Uvin, Pieter, additional, Goossens, Marijn, additional, Poelaert, Filip, additional, De Naeyer, Geert, additional, Schatteman, Peter, additional, Collins, Justin, additional, Mottrie, Alexandre, additional, and Dell’Oglio, Paolo, additional
Published: 2021
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228. Echocardiographic assessment of aortic elastic properties with automated border detection in an ICU: in vivo application of the arctangent Langewouters model

Author: Heerman, Jan R., Segers, Patrick, Roosens, Carl D., Gasthuys, Frank, Verdonck, Pascal R., and Poelaert, Jan I.
Subjects: Coronary artery bypass -- Research, Heart -- Research, Biological sciences
Abstract: We studied whether combined pressure and transesophageal ultrasound monitoring is feasible in the intensive care unit (ICU) setting for global cardiovascular hemodynamic monitoring [systemic vascular resistance (SVR) and total arterial compliance (CPPM)] and direct estimation of local ascending and descending aortic mechanical properties, i.e., distensibility and compliance coefficients (DC and CC). Pressure-area data were fitted to the arctangent Langewouters model, with aortic cross-sectional area obtained via automated border detection. Data were measured in 19 subjects at baseline, during infusion of sodium nitroprusside (SNP), and alter washout. SNP infusion lowered SVR from 1.15 [+ or -] 0.40 to 0.80 [+ or -] 0.32 mmHg x [ml.sup.-1] x s (P < 0.05). whereas CppM increased from 0.87 [+ or -] 0.46 to 1.02 [+ or -] 0.42 ml/mmHg (P < 0.05). DC and CC increased from 0.0018 [+ or -] 0.0007 to 0.0025 [+ or -] 0.0009 1/mmHg (P < 0.05) and from 0.0066 [+ or -] 0.0028 to 0.0083 [+ or -] 0.0026 [cm.sup.2]/mmHg (P < 0.05), respectively, at the descending, but not ascending, aorta. The Langewouters model fitted the descending aorta data reasonably well. Assessment of local mechanical properties of the human ascending aorta in a clinical setting by automated border detection remains technically challenging. afterload; large artery function; nitroprusside; coronary artery bypass grafting; intensive care unit
Published: 2005

229. Accuracy and repeatability of pediatric cardiac output measurement using Doppler: 20-year review of the literature

Author: Chew, Michelle S. and Poelaert, Jan
Published: 2003
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230. Hydraulic Bench Testing of the TruCATHTM/TruCCOMTM Continuous Cardiac Output Monitor

Author: Segers, Patrick, Vandenberghe, Stijn, Decruyenaere, Johan, Poelaert, Jan, Wouters, Patrick, Colardyn, Francis, and Verdonck, Pascal
Published: 2003
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231. Application of Spinal Microdialysis in Freely Moving Rats

Author: Umbrain, Vincent, primary, Shi, Lin, additional, Poelaert, Jan, additional, and Smolders, Ilse, additional
Published: 2012
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232. Erlernen von manuellen Fähigkeiten in der Anästhesie

Author: Schüpfer, G. K., Konrad, C., and Poelaert, J. I.
Published: 2003
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233. Safe Single-Dose Administration of Propofol in Patients with Established Brugada Syndrome: A Retrospective Database Analysis

Author: FLAMÉE, PANAGIOTIS, DE ASMUNDIS, CARLO, BHUTIA, JIGME T., CONTE, GIULIO, BECKERS, STEFAN, UMBRAIN, VINCENT, VERBORGH, CHRISTIAN, CHIERCHIA, GIAN-BATTISTA, VAN MALDEREN, SOPHIE, CASADO-ARROYO, RUBÉN, SARKOZY, ANDREA, BRUGADA, PEDRO, and POELAERT, JAN
Published: 2013
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234. Assessment of intraoperative microaspiration: does a modified cuff shape improve sealing?

Author: DʼHAESE, J., De Keukeleire, T., Remory, I., Van Rompaey, K., Umbrain, V., and Poelaert, J.
Published: 2013
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235. Bioenergetic balance of crrt. a post-hoc analysis of the meccias trial

Author: Joop Jonckheer, E. De Waele, and Jan Poelaert
Subjects: medicine.medical_specialty, Nutrition and Dietetics, Physical medicine and rehabilitation, Balance (accounting), business.industry, Endocrinology, Diabetes and Metabolism, Post-hoc analysis, Medicine, business
Published: 2021
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236. Abstract P118: Analysis of macrophage function and histone deacetylase inhibition in neuroblastoma

Author: Gabrielle L. Brumfield, Shelby M. Knoche, Alaina C. Larson, Brittany J. Poelaert, Benjamin T. Goetz, Poomy Pandey, Donald W. Coulter, and Joyce C. Solheim
Subjects: Cancer Research, Oncology
Abstract: Background: Neuroblastoma is the third most common childhood cancer and accounts for 12% of cancer-associated deaths in children under the age of 15. Treatment of neuroblastoma with the histone deacetylase inhibitor (HDACi) vorinostat induces increased infiltration of macrophages with upregulated immune cell-surface receptors. Neuroblastoma cells release VEGF and M-CSF, which may alter intratumoral macrophage populations. VEGF has also been implicated in alteration of amyloid precursor protein family processing. Our lab demonstrated that amyloid precursor protein 2 (APLP2), a member of the amyloid precursor protein family, plays an important role in the migration of tumor cells. APLP2 is known to be expressed by macrophages, but no studies have previously examined macrophage functions that are impacted by APLP2 in the context of neuroblastoma disease and its treatment by HDACi drugs. Because of the high morbidity and mortality associated with neuroblastoma, studies such as this one that are designed to comprehend the interaction of immunity and treatment in neuroblastoma are clinically significant. Methods: We treated neuroblastoma tumor cells (Neuro-2a) in vitro with M344, an HDACi with structural similarity to vorinostat, and assessed viability through MTT assay. In addition, we generated mice with APLP2 knockout in cells expressing the Csf-1 receptor (a protein characteristically expressed by macrophages and dendritic cells). Polarization of macrophages isolated from the macrophage-targeted APLP2-knockout mice was achieved through treatment with IFN-γ and LPS (M1) or IL-4 (M2). Macrophages were then analyzed through western blotting and flow cytometry for APLP2 expression and polarization markers. Results: Following polarization, macrophages collected from the bone marrow of macrophage-targeted APLP2-knockout mice have an altered distribution of M1 and M2 sub-populations, which are macrophage sub-populations that differ in their migratory capabilities, as well as in their abilities to stimulate or suppress anti-tumor immunity. Furthermore, we showed that M1 and M2 subpopulations of bone marrow-derived macrophages from normal mice differ in their expression of APLP2. We also demonstrated that M344 decreased neuroblastoma cell growth. Thus, APLP2 is influential in macrophage biology, and we have created a novel mouse model for defining its specific contributions in mice treated with HDACi drugs that influence macrophage biology. Conclusions: We have made progress in understanding the impact of the HDACi drug M344 on neuroblastoma cells and are ready to analyze its impact on macrophage/dendritic cell populations in a syngeneic neuroblastoma mouse model, as well as to define the role of APLP2 in the function of these cell populations in the context of neuroblastoma. In addition to their potential contribution to the development of new neuroblastoma therapies, the results from this study are expected to expand our comprehension of macrophage function and regulation, and thus will be of broad value in the immunology and oncology fields. Citation Format: Gabrielle L. Brumfield, Shelby M. Knoche, Alaina C. Larson, Brittany J. Poelaert, Benjamin T. Goetz, Poomy Pandey, Donald W. Coulter, Joyce C. Solheim. Analysis of macrophage function and histone deacetylase inhibition in neuroblastoma [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2021 Oct 7-10. Philadelphia (PA): AACR; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P118.
Published: 2021
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237. APROTININ USE IN HIGH-RISK CARDIAC SURGERY: RECENT INSIGHTS FROM THE BELGIAN APROTININ PATIENT REGISTRY

Author: Carla Van Gompel, Koen Lapage, Steffen Rex, Stefan Jacobs, Stefaan Bouchez, Jan Poelaert, Guy Schols, and Patrick Lecomte
Subjects: Creatinine, education.field_of_study, medicine.medical_specialty, business.industry, medicine.medical_treatment, Population, Cardiac surgery, law.invention, chemistry.chemical_compound, Anesthesiology and Pain Medicine, chemistry, law, Anesthesia, medicine, Cardiopulmonary bypass, Aprotinin, Tamponade, Cardiology and Cardiovascular Medicine, education, Risk assessment, business, Dialysis, medicine.drug
Abstract: Introduction In 2007, the use of aprotinin was temporarily suspended following several publications raising serious safety concerns.(1.2.3) However, Canadian and European Health Authorities concluded that these studies suffered from major flaws and lifted the suspension in 2013.(4,5) The reintroduction of aprotinin in 2016 was accompanied by a mandatory registry [Nordic Aprotinin Patient Registry (NAPaR)] in order to monitor the pattern of use, the effect of risk minimization measures, and overall safety. Objective of this study was to analyse the use of aprotinin in Belgium. Methods NAPaR is a non-interventional Post-Authorisation Safety Study (PASS), endorsed by the Pharmacovigilance Risk Assessment Committee of the European Medicine Agency. Results Between October 2018 and August 2020, six Belgian NAPaR centers included 694 patients [median age 70 (range 13-90y); 62% male; median EuroSCORE II 4.6 (range 0.5-93.4)]. 25% of the patients had an EuroSCOREII > 10. 57% of the patients were under an active antiplatelet therapy and 17% were treated with novel oral anti-coagulants. Preoperative renal impairment was present in 2/3 of patients. Only 4% of the patients received aprotinin on-label, i.e. for isolated coronary artery bypass grafting (CABG) on cardiopulmonary bypass (CPB). In 96% of the patients, aprotinin was used off-label, mainly for redo surgery (32%), CABG + valve surgery (29%), aortic surgery (20%) and multiple valve surgery (17%). One third of the procedures were urgent (23%) or emergent (9%). Median bypass time was 128min (range 13-600min). Median hospital stay was 11 days (range 3-151 days). Main reported indications for the use of aprotinin were active dual antiplatelet therapy (68% in iCABG), redo surgery (16%) and expected prolonged CPB time (55%). In 83% of the cases, aprotinin was administered at the Half Hammersmith dose (1 Mio KIU loading- and priming-dose + 250.000 KIU/h); most patients received the appropriate test dose (98%), none developed anaphylactic reactions. Median perioperative blood loss was 400ml (range 40 -10050 ml), 44% of the patients had RBC transfusion and 6% underwent reoperation for bleeding or tamponade. Overall mortality at discharge was 5%, i.e. within the range or lower than predicted by the EuroSCORE II. 2% of the patients had a postoperative stroke. Postoperative AKI as defined by a serum creatinine increase of 0,3mg/dL or more within 48 hours after surgery was present in 13% of cases. Most of these patients (76%) suffered from preoperative moderate or severe renal impairment including dialysis. Notably, in patients with postoperative AKI median CPB time was significantly higher than in patients without AKI: 172min (range 56-402) vs 125min (range 13-600min) (p Discussion In the Belgian centers, aprotinin was mainly used off-label and predominantly administered to older patients with significant comorbidities undergoing high-risk procedures. The observed safety outcomes are in line with published data within this high risk patient population. The data from the Belgian NAPaR suggest that aprotinin has an excellent safety profile in adult cardiac surgery.
Published: 2021
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238. Transesophageal Echocardiography: Principal Views

Author: Poelaert, Jan, primary
Published: 2010
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239. Hemodynamic Instability in Cardiac Surgical Patients

Author: Cholley, Bernard P., primary, Cherqui, Mireille, additional, Berrebi, Alain, additional, and Poelaert, Jan, additional
Published: 2010
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240. Transoesophageale Echokardiographie zur Evaluation der linksventrikulären Funktion

Author: Poortmans, G., Schüpfer, G., Roosens, C., and Poelaert, J.
Published: 2001
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241. Multicentre, prospective study on local treatment of metastatic prostate cancer (LoMP study).

Author: Buelens, Sarah, Poelaert, Filip, Claeys, Tom, De Bleser, Elise, Dhondt, Bert, Verla, Wesley, Ost, Piet, Rappe, Bernard, De Troyer, Bart, Verbaeys, Caroline, Kimpe, Bart, Billiet, Ignace, Plancke, Hendrik, Fransis, Karen, Willemen, Patrick, Ameye, Filip, Decaestecker, Karel, and Lumen, Nicolaas
Subjects: *PROSTATECTOMY, *METASTASIS, *RADICAL prostatectomy, *PROSTATE cancer, *ASYMPTOMATIC patients, *LONGITUDINAL method
Abstract: Objectives: To investigate the role of cytoreductive radical prostatectomy in addition to standard of care for patients with newly diagnosed metastatic prostate cancer. Materials and Methods: This multicentre, prospective study included asymptomatic patients from 2014 to 2018 (NCT02138721). Cytoreductive radical prostatectomy was offered to all fit patients with resectable tumours, resulting in 40 patients. Standard of care was administered to 40 patients who were ineligible or unwilling to undergo surgery. The primary endpoint was castration resistant cancer‐free survival at the time point of ≥50% events. The secondary endpoint was local event‐free survival. Kaplan–Meier and Cox regression analyses with propensity‐score analysis were applied. Results: After a median (quartiles) follow‐up of 35 (24–47) months, 42 patients became castration‐resistant or died. The median castration resistant cancer‐free survival was 53 (95% confidence interval [CI] 14–92) vs 21 (95% CI 15–27) months for cytoreductive radical prostatectomy compared to standard of care (P = 0.017). The 3‐year estimates for local event‐free survival were 83% (95% CI 71–95) vs 59% (95% CI 51–67) for cytoreductive radical prostatectomy compared to standard of care (P = 0.012). However, treatment group showed no significance in the multivariable models for castration resistant cancer‐free survival (P = 0.5) or local event‐free survival (P = 0.3), adjusted for propensity‐score analysis. Complications were similar to the non‐metastatic setting. Patients undergoing surgery were younger, with lower baseline prostate‐specific antigen levels, alkaline phosphatase levels and metastatic burden. Conclusion: The present LoMP study was unable to show a difference between the two inclusion groups regarding castration resistant cancer‐free survival for asymptomatic patients with newly diagnosed metastatic prostate cancer. These results validate previous evidence that, in well‐selected and informed patients, cytoreductive radical prostatectomy is feasible and safe, with corresponding continence rates compared to the non‐metastatic, high‐risk setting. Whether cytoreductive radical prostatectomy could be a valuable option to achieve good local palliation needs to be further researched. Overall, the role of cytoreductive radical prostatectomy needs to be further explored in randomized studies to correct for potential bias. [ABSTRACT FROM AUTHOR]
Published: 2022
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242. Functional Mitral Regurgitation in the Critically Ill

Author: Poelaert, J., primary
Published: 2009
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243. Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications:LAS VEGAS - An observational study in 29 countries

Author: Schultz, Marcus J., Hemmes, Sabrine N. T., Neto, Ary Serpa, Binnekade, Jan M., Canet, Jaume, Hedenstierna, Goran, Jaber, Samir, Hiesmayr, Michael, Hollmann, Markus W., Mills, Gary H., Vidal Melo, Marcos F., Pearse, Rupert, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Wrigge, Hermann, De Abreu, Marcelo Gama, Pelosi, Paolo, Kroell W, Metzler H, Struber G, Wegscheider T, Gombotz H, Hiesmayr M, Schmid W, Urbanek B, Leva B, Damster S, Plichon B, Kahn D, Momeni M, Pospiech A, Lois F, Forget P, Grosu I, Poelaert J, van Mossevelde V, van Malderen MC, Dylst D, van Melkebeek J, Beran M, de Hert S, De Baerdemaeker L, Heyse B, van Limmen J, Wyffels P, Jacobs T, Roels N, De Bruyne A, van de Velde S, Juros-Zovko M, Djonoviċ-Omanoviċ D, Serpa Neto A, Pernar S, Zunic J, Miskovic P, Zilic A, Kvolik S, Ivic D, Azenic-Venzera D, Skiljic S, Vinkovic H, Oputric I, Juricic K, Frkovic V, Kopic J, Mirkovic I, Karanovic N, Carev M, Dropulic N, Pavičić-Šarić J, Erceg G, Bogdanović Dvorščak M, Mazul-Sunko B, Pavicic AM, Goranovic T, Maldini B, Radocaj T, Gavranovic Z, Mladic-Batinica I, Sehovic M, Stourac P, Harazim H, Smekalova O, Kosinova M, Kolacek T, Hudacek K, Drab M, Brujevic J, Vitkova K, Jirmanova K, Volfova I, Dzurnakova P, Liskova K, Dudas R, Filipsky R, El Kafrawy S, Hosny Abdelwahab H, Metwally T, Abdel-Razek A, El-Shaarawy AM, Fathy Hasan W, Gouda Ahmed A, Yassin H, Magdy M, Abdelhady M, Mahran M, Herodes E, Kivik P, Oganjan J, Aun A, Sormus A, Sarapuu K, Mall M, Karjagin J, Futier E, Petit A, Gerard A, Marret E, Solier M, Jaber S, Prades A, Putensen C, Krassler J, Merzky S, Gama de Abreu M, Uhlig C, Kiss T, Bundy A, Bluth T, Güldner A, Spieth P, Scharffenberg M, Tran Thiem D, Koch T, Treschan T, Schaefer M, Bastin B, Geib J, Weiss M, Kienbaum P, Pannen B, Gottschalk A, Konrad M, Westerheide D, Schwerdtfeger B, Wrigge H, Simon P, Reske A, Nestler C, Valsamidis D, Stroumpoulis K, Antholopoulos G, Andreou A, Karapanos D, Theodoraki K, Gkiokas G, Tasoulis MK, Sidiropoulou T, Zafeiropoulou F, Florou P, Pandazi A, Tsaousi G, Nouris C, Pourzitaki C, Bystritski D, Pizov R, Eden A, Pesce CV, Campanile A, Marrella A, Grasso S, De Michele M, Bona F, Giacoletto G, Sardo E, Giancarlo L, Sottosanti V, Solca M, Volta CA, Spadaro S, Verri M, Ragazzi R, Zoppellari R, Cinnella G, Raimondo P, La Bella D, Mirabella L, D'antini D, Pelosi P, Molin A, Brunetti I, Gratarola A, Pellerano G, Sileo R, Pezzatto S, Montagnani L, Pasin L, Landoni G, Zangrillo A, Beretta L, Di Parma AL, Tarzia V, Dossi R, Sassone ME, Sances D, Tredici S, Spano G, Castellani G, Delunas L, Peradze S, Venturino M, Arpino I, Sher S, Tommasino C, Rapido F, Morelli P, Vargas M, Servillo G, Cortegiani A, Raineri SM, Montalto F, Russotto V, Giarratano A, Baciarello M, Generali M, Cerati G, Leykin Y, Bressan F, Bartolini V, Zamidei L, Brazzi L, Liperi C, Sales G, Pistidda L, Severgnini P, Brugnoni E, Musella G, Bacuzzi A, Muhardri D, Gecaj-Gashi A, Sada F, Bytyqi A, Karbonskiene A, Aukstakalniene R, Teberaite Z, Salciute E, Tikuisis R, Miliauskas P, Jurate S, Kontrimaviciute E, Tomkute G, Xuereb J, Bezzina M, Borg FJ, Hemmes S, Schultz M, Hollmann M, Wiersma I, Binnekade J, Bos L, Boer C, Duvekot A, In 't Veld B, Werger A, Dennesen P, Severijns C, de Jong J, Hering J, van Beek R, Ivars S, Jammer I, Breidablik A, Skirstad Hodt K, Fjellanger F, VicoAvalos M, Mellin-Olsen J, Andersson E, Shafi-Kabiri A, Molina R, Wutai S, Morais E, Tareco GR, Ferreira D, Amaral J, Gonçalves Castro ML, Cadilha S, Appleton S, Parente S, Correia M, Martins D, Monteirosa A, Ricardo A, Rodrigues S, Horhota L, Grintescu IM, Mirea L, Grintescu IC, Corneci D, Negoita S, Dutu M, Popescu Garotescu I, Filipescu D, Prodan AB, Droc G, Fota R, Popescu M, Tomescu D, Petcu AM, Tudoroiu MI, Moise A, Guran CT, Gherghina I, Costea D, Cindea I, Copotoiu SM, Copotoiu R, Barsan V, Tolcser Z, Riciu M, Moldovan GS, Veres M, Gritsan A, Kapkan T, Gritsan G, Korolkov O, Kulikov A, Lubnin A, Ovezov A, Prokoshev P, Lugovoy A, Anipchenko N, Babayants A, Komissarova I, Zalina K, Likhvantsev V, Fedorov S, Lazukic A, Pejakovic J, Mihajlovic D, Kusnierikova Z, Zelinkova M, Bruncakova K, Polakovicova L, Sobona V, Novak-Supe B, Pekle-Golez A, Jovanov M, Strazisar B, Markovic-Bozic J, Novak-Jankovic V, Voje M, Grynyuk A, Kostadinov I, Spindler-Vesel A, Moral V, Unzueta C, Puigbo C, Fava J, Canet J, Moret E, Rodriguez Nunez MN, Sendra M, Brunelli A, Rodenas F, Monedero P, Hidalgo Martinez F, Yepes Temino MJ, Marti Nez Simon A, de Abajo Larriba A, Lisi A, Perez G, Martinez R, Granell M, Tatay Vivo J, Saiz Ruiz C, de Andre S Iban Ez JA, Pastor E, Soro M, Ferrando C, Defez M, Aldecoa Alvares-Santullano C, Pere R, Rico J, Jawad M, Saeed Y, Gillberg L, Hedenstierna G, Kazak Bengisun Z, Kansu Kazbek B, Coskunfirat N, Boztug N, Sanli S, Yilmaz M, Hadimioglu N, Senturk NM, Camci E, Kucukgoncu S, Sungur Z, Sivrikoz N, Ustalar Ozgen S, Toraman F, Selvi O, Senturk O, Yildiz M, Kuvaki B, Gunenc F, Kucukguclu S, Ozbilgin SU, Maral J, Canli S, Arun O, Saltali A, Aydogan E, Akgün FN, Sanlikarip C, Mine Karaman F, Mazur A, Vorotyntsev S, Rousseau G, Barrett C, Stancombe L, Shelley B, Scholes H, Limb J, Rafi A, Wayman L, Deane J, Rogerson D, Williams J, Yates S, Rogers E, Pulletz M, Moreton S, Jones S, Venkatesh S, Burton M, Brown L, Goodall C, Rucklidge M, Fuller D, Nadolski M, Kusre S, Lundberg M, Everett L, Nutt H, Zuleika M, Carvalho P, Clements D, Creagh-Brown B, Watt P, Raymode P, Pearse R, Mohr O, Raj A, Creary T, Chishti A, Bell A, Higham C, Cain A, Gibb S, Mowat S, Franklin D, West C, Minto G, Boyd N, Mills G, Calton E, Walker R, Mackenzie F, Ellison B, Roberts H, Chikungwa M, Jackson C, Donovan A, Foot J, Homan E, Montgomery J, Portch D, Mercer P, Palmer J, Paddle J, Fouracres A, Datson A, Andrew A, Welch L, Rose A, Varma S, Simeson K, Rambhatla M, Susarla J, Marri S, Kodaganallur K, Das A, Algarsamy S, Colley J, Davies S, Szewczyk M, Smith T, Fernandez-Bustamante A, Luzier E, Almagro A, Vidal Melo M, Fernando L, Sulemanji D, Sprung J, Weingarten T, Kor D, Scavonetto F, Tze Y., Schultz, M, Hemmes, S, Neto, A, Binnekade, J, Canet, J, Hedenstierna, G, Jaber, S, Hiesmayr, M, Hollmann, M, Mills, G, Vidal Melo, M, Pearse, R, Putensen, C, Schmid, W, Severgnini, P, Wrigge, H, De Abreu, M, Pelosi, P, Kroell, W, Metzler, H, Struber, G, Wegscheider, T, Gombotz, H, Urbanek, B, Leva, B, Damster, S, Plichon, B, Kahn, D, Momeni, M, Pospiech, A, Lois, F, Forget, P, Grosu, I, Poelaert, J, van Mossevelde, V, van Malderen, M, Dylst, D, van Melkebeek, J, Beran, M, de Hert, S, De Baerdemaeker, L, Heyse, B, van Limmen, J, Wyffels, P, Jacobs, T, Roels, N, De Bruyne, A, van de Velde, S, Juros-Zovko, M, Djonovic-Omanovic, D, Pernar, S, Zunic, J, Miskovic, P, Zilic, A, Kvolik, S, Ivic, D, Azenic-Venzera, D, Skiljic, S, Vinkovic, H, Oputric, I, Juricic, K, Frkovic, V, Kopic, J, Mirkovic, I, Karanovic, N, Carev, M, Dropulic, N, Pavicic-Saric, J, Erceg, G, Bogdanovic Dvorcak, M, Mazul-Sunko, B, Pavicic, A, Goranovic, T, Maldini, B, Radocaj, T, Gavranovic, Z, Mladic-Batinica, I, Sehovic, M, Stourac, P, Harazim, H, Smekalova, O, Kosinova, M, Kolacek, T, Hudacek, K, Drab, M, Brujevic, J, Vitkova, K, Jirmanova, K, Volfova, I, Dzurnakova, P, Liskova, K, Dudas, R, Filipsky, R, El Kafrawy, S, Hosny Abdelwahab, H, Metwally, T, Abdel-Razek, A, El-Shaarawy, A, Fathy Hasan, W, Gouda Ahmed, A, Yassin, H, Magdy, M, Abdelhady, M, Mahran, M, Herodes, E, Kivik, P, Oganjan, J, Aun, A, Sormus, A, Sarapuu, K, Mall, M, Karjagin, J, Futier, E, Petit, A, Gerard, A, Marret, E, Solier, M, Prades, A, Krassler, J, Merzky, S, Uhlig, C, Kiss, T, Bundy, A, Bluth, T, Guldner, A, Spieth, P, Scharffenberg, M, Tran Thiem, D, Koch, T, Treschan, T, Schaefer, M, Bastin, B, Geib, J, Weiss, M, Kienbaum, P, Pannen, B, Gottschalk, A, Konrad, M, Westerheide, D, Schwerdtfeger, B, Simon, P, Reske, A, Nestler, C, Valsamidis, D, Stroumpoulis, K, Antholopoulos, G, Andreou, A, Karapanos, D, Theodoraki, K, Gkiokas, G, Tasoulis, M, Sidiropoulou, T, Zafeiropoulou, F, Florou, P, Pandazi, A, Tsaousi, G, Nouris, C, Pourzitaki, C, Bystritski, D, Pizov, R, Eden, A, Pesce, C, Campanile, A, Marrella, A, Grasso, S, De Michele, M, Bona, F, Giacoletto, G, Sardo, E, Giancarlo, L, Sottosanti, V, Solca, M, Volta, C, Spadaro, S, Verri, M, Ragazzi, R, Zoppellari, R, Cinnella, G, Raimondo, P, La Bella, D, Mirabella, L, D'Antini, D, Molin, A, Brunetti, I, Gratarola, A, Pellerano, G, Sileo, R, Pezzatto, S, Montagnani, L, Pasin, L, Landoni, G, Zangrillo, A, Beretta, L, Di Parma, A, Tarzia, V, Dossi, R, Sassone, M, Sances, D, Tredici, S, Spano, G, Castellani, G, Delunas, L, Peradze, S, Venturino, M, Arpino, I, Sher, S, Tommasino, C, Rapido, F, Morelli, P, Vargas, M, Servillo, G, Cortegiani, A, Raineri, S, Montalto, F, Russotto, V, Giarratano, A, Baciarello, M, Generali, M, Cerati, G, Leykin, Y, Bressan, F, Bartolini, V, Zamidei, L, Brazzi, L, Liperi, C, Sales, G, Pistidda, L, Brugnoni, E, Musella, G, Bacuzzi, A, Muhardri, D, Gecaj-Gashi, A, Sada, F, Bytyqi, A, Karbonskiene, A, Aukstakalniene, R, Teberaite, Z, Salciute, E, Tikuisis, R, Miliauskas, P, Jurate, S, Kontrimaviciute, E, Tomkute, G, Xuereb, J, Bezzina, M, Borg, F, Wiersma, I, Bos, L, Boer, C, Duvekot, A, In't Veld, B, Werger, A, Dennesen, P, Severijns, C, de Jong, J, Hering, J, van Beek, R, Ivars, S, Jammer, I, Breidablik, A, Skirstad Hodt, K, Fjellanger, F, Vicoavalos, M, Mellin-Olsen, J, Andersson, E, Shafi-Kabiri, A, Molina, R, Wutai, S, Morais, E, Tareco, G, Ferreira, D, Amaral, J, Goncalves Castro, M, Cadilha, S, Appleton, S, Parente, S, Correia, M, Martins, D, Monteirosa, A, Ricardo, A, Rodrigues, S, Horhota, L, Grintescu, I, Mirea, L, Corneci, D, Negoita, S, Dutu, M, Popescu Garotescu, I, Filipescu, D, Prodan, A, Droc, G, Fota, R, Popescu, M, Tomescu, D, Petcu, A, Tudoroiu, M, Moise, A, Guran, C, Gherghina, I, Costea, D, Cindea, I, Copotoiu, S, Copotoiu, R, Barsan, V, Tolcser, Z, Riciu, M, Moldovan, G, Veres, M, Gritsan, A, Kapkan, T, Gritsan, G, Korolkov, O, Kulikov, A, Lubnin, A, Ovezov, A, Prokoshev, P, Lugovoy, A, Anipchenko, N, Babayants, A, Komissarova, I, Zalina, K, Likhvantsev, V, Fedorov, S, Lazukic, A, Pejakovic, J, Mihajlovic, D, Kusnierikova, Z, Zelinkova, M, Bruncakova, K, Polakovicova, L, Sobona, V, Novak-Supe, B, Pekle-Golez, A, Jovanov, M, Strazisar, B, Markovic-Bozic, J, Novak-Jankovic, V, Voje, M, Grynyuk, A, Kostadinov, I, Spindler-Vesel, A, Moral, V, Unzueta, C, Puigbo, C, Fava, J, Moret, E, Rodriguez Nunez, M, Sendra, M, Brunelli, A, Rodenas, F, Monedero, P, Hidalgo Martinez, F, Yepes Temino, M, Marti Nez Simon, A, de Abajo Larriba, A, Lisi, A, Perez, G, Martinez, R, Granell, M, Tatay Vivo, J, Saiz Ruiz, C, de Andre S Iban Ez, J, Pastor, E, Soro, M, Ferrando, C, Defez, M, Aldecoa Alvares-Santullano, C, Pere, R, Rico, J, Jawad, M, Saeed, Y, Gillberg, L, Kazak Bengisun, Z, Kansu Kazbek, B, Coskunfirat, N, Boztug, N, Sanli, S, Yilmaz, M, Hadimioglu, N, Senturk, N, Camci, E, Kucukgoncu, S, Sungur, Z, Sivrikoz, N, Ustalar Ozgen, S, Toraman, F, Selvi, O, Senturk, O, Yildiz, M, Kuvaki, B, Gunenc, F, Kucukguclu, S, Ozbilgin, S, Maral, J, Canli, S, Arun, O, Saltali, A, Aydogan, E, Akgun, F, Sanlikarip, C, Mine Karaman, F, Mazur, A, Vorotyntsev, S, Rousseau, G, Barrett, C, Stancombe, L, Shelley, B, Scholes, H, Limb, J, Rafi, A, Wayman, L, Deane, J, Rogerson, D, Williams, J, Yates, S, Rogers, E, Pulletz, M, Moreton, S, Jones, S, Venkatesh, S, Burton, M, Brown, L, Goodall, C, Rucklidge, M, Fuller, D, Nadolski, M, Kusre, S, Lundberg, M, Everett, L, Nutt, H, Zuleika, M, Carvalho, P, Clements, D, Creagh-Brown, B, Watt, P, Raymode, P, Mohr, O, Raj, A, Creary, T, Chishti, A, Bell, A, Higham, C, Cain, A, Gibb, S, Mowat, S, Franklin, D, West, C, Minto, G, Boyd, N, Calton, E, Walker, R, Mackenzie, F, Ellison, B, Roberts, H, Chikungwa, M, Jackson, C, Donovan, A, Foot, J, Homan, E, Montgomery, J, Portch, D, Mercer, P, Palmer, J, Paddle, J, Fouracres, A, Datson, A, Andrew, A, Welch, L, Rose, A, Varma, S, Simeson, K, Rambhatla, M, Susarla, J, Marri, S, Kodaganallur, K, Das, A, Algarsamy, S, Colley, J, Davies, S, Szewczyk, M, Smith, T, Fernandez-Bustamante, A, Luzier, E, Almagro, A, Fernando, L, Sulemanji, D, Sprung, J, Weingarten, T, Kor, D, Scavonetto, F, Tze, Y, Schultz, M. J., Hemmes, S. N. T., Neto, A. S., Binnekade, J. M., Canet, J., Hedenstierna, G., Jaber, S., Hiesmayr, M., Hollmann, M. W., Mills, G. H., Vidal Melo, M. F., Pearse, R., Putensen, C., Schmid, W., Severgnini, P., Wrigge, H., De Abreu, M. G., Pelosi, P., Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Urbanek, B., Leva, B., Damster, S., Plichon, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., van Mossevelde, V., van Malderen, M. C., Dylst, D., van Melkebeek, J., Beran, M., de Hert, S., De Baerdemaeker, L., Heyse, B., van Limmen, J., Wyffels, P., Jacobs, T., Roels, N., De Bruyne, A., van de Velde, S., Juros-Zovko, M., Djonovic-Omanovic, D., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Azenic-Venzera, D., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Karanovic, N., Carev, M., Dropulic, N., Pavicic-Saric, J., Erceg, G., Bogdanovic Dvorcak, M., Mazul-Sunko, B., Pavicic, A. M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Mladic-Batinica, I., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., El Kafrawy, S., Hosny Abdelwahab, H., Metwally, T., Abdel-Razek, A., El-Shaarawy, A. M., Fathy Hasan, W., Gouda Ahmed, A., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Prades, A., Krassler, J., Merzky, S., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Guldner, A., Spieth, P., Scharffenberg, M., Tran Thiem, D., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M. K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C. V., Campanile, A., Marrella, A., Grasso, S., De Michele, M., Bona, F., Giacoletto, G., Sardo, E., Giancarlo, L., Sottosanti, V., Solca, M., Volta, C. A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., La Bella, D., Mirabella, L., D'Antini, D., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Di Parma, A. L., Tarzia, V., Dossi, R., Sassone, M. E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S. M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Gecaj-Gashi, A., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. J., Wiersma, I., Bos, L., Boer, C., Duvekot, A., In't Veld, B., Werger, A., Dennesen, P., Severijns, C., de Jong, J., Hering, J., van Beek, R., Ivars, S., Jammer, I., Breidablik, A., Skirstad Hodt, K., Fjellanger, F., Vicoavalos, M., Mellin-Olsen, J., Andersson, E., Shafi-Kabiri, A., Molina, R., Wutai, S., Morais, E., Tareco, G. R., Ferreira, D., Amaral, J., Goncalves Castro, M. L., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I. M., Mirea, L., Grintescu, I. C., Corneci, D., Negoita, S., Dutu, M., Popescu Garotescu, I., Filipescu, D., Prodan, A. B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A. M., Tudoroiu, M. I., Moise, A., Guran, C. T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S. M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, G. S., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Novak-Supe, B., Pekle-Golez, A., Jovanov, M., Strazisar, B., Markovic-Bozic, J., Novak-Jankovic, V., Voje, M., Grynyuk, A., Kostadinov, I., Spindler-Vesel, A., Moral, V., Unzueta, C., Puigbo, C., Fava, J., Moret, E., Rodriguez Nunez, M. N., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Hidalgo Martinez, F., Yepes Temino, M. J., Marti Nez Simon, A., de Abajo Larriba, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Tatay Vivo, J., Saiz Ruiz, C., de Andre S Iban Ez, J. A., Pastor, E., Soro, M., Ferrando, C., Defez, M., Aldecoa Alvares-Santullano, C., Pere, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Kazak Bengisun, Z., Kansu Kazbek, B., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N. M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ustalar Ozgen, S., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S. U., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F. N., Sanlikarip, C., Mine Karaman, F., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Creagh-Brown, B., Watt, P., Raymode, P., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Fernandez-Bustamante, A., Luzier, E., Almagro, A., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Anesthesiology, ACS - Microcirculation, ACS - Diabetes & metabolism, Landoni, Giovanni, Zangrillo, Alberto, Beretta, Luigi, Schultz, Marcus J., Hemmes, Sabrine N.T., Neto, Ary Serpa, Binnekade, Jan M., Canet, Jaume, Hedenstierna, Goran, Jaber, Samir, Hiesmayr, Michael, Hollmann, Markus W., Mills, Gary H., Vidal Melo, Marcos F., Pearse, Rupert, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Wrigge, Hermann, De Abreu, Marcelo Gama, Pelosi, Paolo, Kroell W, Metzler H, Struber G, Wegscheider T, Gombotz H, Hiesmayr M, Schmid W, Urbanek B, Leva B, Damster S, Plichon B, Kahn D, Momeni M, Pospiech A, Lois F, Forget P, Grosu I, Poelaert J, van Mossevelde V, van Malderen MC, Dylst D, van Melkebeek J, Beran M, de Hert S, De Baerdemaeker L, Heyse B, van Limmen J, Wyffels P, Jacobs T, Roels N, De Bruyne A, van de Velde S, Juros-Zovko M, Djonoviċ-Omanoviċ D, Serpa Neto A, Pernar S, Zunic J, Miskovic P, Zilic A, Kvolik S, Ivic D, Azenic-Venzera D, Skiljic S, Vinkovic H, Oputric I, Juricic K, Frkovic V, Kopic J, Mirkovic I, Karanovic N, Carev M, Dropulic N, Pavičić-Šarić J, Erceg G, Bogdanović Dvorščak M, Mazul-Sunko B, Pavicic AM, Goranovic T, Maldini B, Radocaj T, Gavranovic Z, Mladic-Batinica I, Sehovic M, Stourac P, Harazim H, Smekalova O, Kosinova M, Kolacek T, Hudacek K, Drab M, Brujevic J, Vitkova K, Jirmanova K, Volfova I, Dzurnakova P, Liskova K, Dudas R, Filipsky R, El Kafrawy S, Hosny Abdelwahab H, Metwally T, Abdel-Razek A, El-Shaarawy AM, Fathy Hasan W, Gouda Ahmed A, Yassin H, Magdy M, Abdelhady M, Mahran M, Herodes E, Kivik P, Oganjan J, Aun A, Sormus A, Sarapuu K, Mall M, Karjagin J, Futier E, Petit A, Gerard A, Marret E, Solier M, Jaber S, Prades A, Putensen C, Krassler J, Merzky S, Gama de Abreu M, Uhlig C, Kiss T, Bundy A, Bluth T, Güldner A, Spieth P, Scharffenberg M, Tran Thiem D, Koch T, Treschan T, Schaefer M, Bastin B, Geib J, Weiss M, Kienbaum P, Pannen B, Gottschalk A, Konrad M, Westerheide D, Schwerdtfeger B, Wrigge H, Simon P, Reske A, Nestler C, Valsamidis D, Stroumpoulis K, Antholopoulos G, Andreou A, Karapanos D, Theodoraki K, Gkiokas G, Tasoulis MK, Sidiropoulou T, Zafeiropoulou F, Florou P, Pandazi A, Tsaousi G, Nouris C, Pourzitaki C, Bystritski D, Pizov R, Eden A, Pesce CV, Campanile A, Marrella A, Grasso S, De Michele M, Bona F, Giacoletto G, Sardo E, Giancarlo L, Sottosanti V, Solca M, Volta CA, Spadaro S, Verri M, Ragazzi R, Zoppellari R, Cinnella G, Raimondo P, La Bella D, Mirabella L, D'antini D, Pelosi P, Molin A, Brunetti I, Gratarola A, Pellerano G, Sileo R, Pezzatto S, Montagnani L, Pasin L, Landoni G, Zangrillo A, Beretta L, Di Parma AL, Tarzia V, Dossi R, Sassone ME, Sances D, Tredici S, Spano G, Castellani G, Delunas L, Peradze S, Venturino M, Arpino I, Sher S, Tommasino C, Rapido F, Morelli P, Vargas M, Servillo G, Cortegiani A, Raineri SM, Montalto F, Russotto V, Giarratano A, Baciarello M, Generali M, Cerati G, Leykin Y, Bressan F, Bartolini V, Zamidei L, Brazzi L, Liperi C, Sales G, Pistidda L, Severgnini P, Brugnoni E, Musella G, Bacuzzi A, Muhardri D, Gecaj-Gashi A, Sada F, Bytyqi A, Karbonskiene A, Aukstakalniene R, Teberaite Z, Salciute E, Tikuisis R, Miliauskas P, Jurate S, Kontrimaviciute E, Tomkute G, Xuereb J, Bezzina M, Borg FJ, Hemmes S, Schultz M, Hollmann M, Wiersma I, Binnekade J, Bos L, Boer C, Duvekot A, In 't Veld B, Werger A, Dennesen P, Severijns C, de Jong J, Hering J, van Beek R, Ivars S, Jammer I, Breidablik A, Skirstad Hodt K, Fjellanger F, VicoAvalos M, Mellin-Olsen J, Andersson E, Shafi-Kabiri A, Molina R, Wutai S, Morais E, Tareco GR, Ferreira D, Amaral J, Gonçalves Castro ML, Cadilha S, Appleton S, Parente S, Correia M, Martins D, Monteirosa A, Ricardo A, Rodrigues S, Horhota L, Grintescu IM, Mirea L, Grintescu IC, Corneci D, Negoita S, Dutu M, Popescu Garotescu I, Filipescu D, Prodan AB, Droc G, Fota R, Popescu M, Tomescu D, Petcu AM, Tudoroiu MI, Moise A, Guran CT, Gherghina I, Costea D, Cindea I, Copotoiu SM, Copotoiu R, Barsan V, Tolcser Z, Riciu M, Moldovan GS, Veres M, Gritsan A, Kapkan T, Gritsan G, Korolkov O, Kulikov A, Lubnin A, Ovezov A, Prokoshev P, Lugovoy A, Anipchenko N, Babayants A, Komissarova I, Zalina K, Likhvantsev V, Fedorov S, Lazukic A, Pejakovic J, Mihajlovic D, Kusnierikova Z, Zelinkova M, Bruncakova K, Polakovicova L, Sobona V, Novak-Supe B, Pekle-Golez A, Jovanov M, Strazisar B, Markovic-Bozic J, Novak-Jankovic V, Voje M, Grynyuk A, Kostadinov I, Spindler-Vesel A, Moral V, Unzueta C, Puigbo C, Fava J, Canet J, Moret E, Rodriguez Nunez MN, Sendra M, Brunelli A, Rodenas F, Monedero P, Hidalgo Martinez F, Yepes Temino MJ, Marti Nez Simon A, de Abajo Larriba A, Lisi A, Perez G, Martinez R, Granell M, Tatay Vivo J, Saiz Ruiz C, de Andre S Iban Ez JA, Pastor E, Soro M, Ferrando C, Defez M, Aldecoa Alvares-Santullano C, Pere R, Rico J, Jawad M, Saeed Y, Gillberg L, Hedenstierna G, Kazak Bengisun Z, Kansu Kazbek B, Coskunfirat N, Boztug N, Sanli S, Yilmaz M, Hadimioglu N, Senturk NM, Camci E, Kucukgoncu S, Sungur Z, Sivrikoz N, Ustalar Ozgen S, Toraman F, Selvi O, Senturk O, Yildiz M, Kuvaki B, Gunenc F, Kucukguclu S, Ozbilgin SU, Maral J, Canli S, Arun O, Saltali A, Aydogan E, Akgün FN, Sanlikarip C, Mine Karaman F, Mazur A, Vorotyntsev S, Rousseau G, Barrett C, Stancombe L, Shelley B, Scholes H, Limb J, Rafi A, Wayman L, Deane J, Rogerson D, Williams J, Yates S, Rogers E, Pulletz M, Moreton S, Jones S, Venkatesh S, Burton M, Brown L, Goodall C, Rucklidge M, Fuller D, Nadolski M, Kusre S, Lundberg M, Everett L, Nutt H, Zuleika M, Carvalho P, Clements D, Creagh-Brown B, Watt P, Raymode P, Pearse R, Mohr O, Raj A, Creary T, Chishti A, Bell A, Higham C, Cain A, Gibb S, Mowat S, Franklin D, West C, Minto G, Boyd N, Mills G, Calton E, Walker R, Mackenzie F, Ellison B, Roberts H, Chikungwa M, Jackson C, Donovan A, Foot J, Homan E, Montgomery J, Portch D, Mercer P, Palmer J, Paddle J, Fouracres A, Datson A, Andrew A, Welch L, Rose A, Varma S, Simeson K, Rambhatla M, Susarla J, Marri S, Kodaganallur K, Das A, Algarsamy S, Colley J, Davies S, Szewczyk M, Smith T, Fernandez-Bustamante A, Luzier E, Almagro A, Vidal Melo M, Fernando L, Sulemanji D, Sprung J, Weingarten T, Kor D, Scavonetto F, Tze Y., Graduate School, ACS - Pulmonary hypertension & thrombosis, Intensive Care Medicine, AII - Amsterdam institute for Infection and Immunity, AII - Inflammatory diseases, ACS - Amsterdam Cardiovascular Sciences, ACS - Heart failure & arrhythmias, Anesthesiology research group, and Supporting clinical sciences
Subjects: Male, Pediatrics, Internationality, RESPIRATORY-DISTRESS-SYNDROME, 0302 clinical medicine, Postoperative Complications, 030202 anesthesiology, Risk Factors, Epidemiology, ABDOMINAL-SURGERY, 80 and over, Medicine and Health Sciences, General anaesthesia, Anesthesia, END-EXPIRATORY-PRESSURE, BERLIN DEFINITION, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Lung, Aged, 80 and over, Framingham Risk Score, Incidence (epidemiology), Respiration, Middle Aged, Treatment Outcome, Artificial, Female, PRACTICE PATTERNS, Human, medicine.medical_specialty, mechanical ventilation, prospective observational study, Intensive care, Anesthesia, General, NONCARDIOTHORACIC SURGERY, NO, Aged, Cross-Sectional Studies, Humans, Intraoperative Care, Respiration Disorders, Respiration, Artificial, Tidal Volume, Anesthesiology and Pain Medicine, ACUTE LUNG INJURY, 03 medical and health sciences, GENERAL-ANESTHESIA, Internal medicine, medicine, Journal Article, MED/41 - ANESTESIOLOGIA, General, Cross-Sectional Studie, business.industry, Risk Factor, Respiration Disorder, Confidence interval, PROTECTIVE MECHANICAL VENTILATION, Prospective Studie, Relative risk, MAJOR NONCARDIAC SURGERY, Postoperative Complication, business, Abdominal surgery
Abstract: BACKGROUND Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. DESIGN This was a prospective international 1-week observational study using the ‘Assess Respiratory Risk in Surgical Patients in Catalonia risk score’ (ARISCAT score) for PPC for risk stratification. PATIENTS AND SETTING Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. MAIN OUTCOME MEASURES The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. RESULTS A total of 9864 patients fulfilled the inclusion criteria. The incidence of patients at increased risk was 28.4%. The most frequently chosen tidal volume (V T) size was 500 ml, or 7 to 9 ml kg−1 predicted body weight, slightly lower in patients at increased risk of PPCs. Levels of positive end-expiratory pressure (PEEP) were slightly higher in patients at increased risk of PPCs, with 14.3% receiving more than 5 cmH2O PEEP compared with 7.6% in patients at low risk of PPCs (P ˂ 0.001). Patients with a predicted preoperative increased risk of PPCs developed PPCs more frequently: 19 versus 7%, relative risk (RR) 3.16 (95% confidence interval 2.76 to 3.61), P ˂ 0.001) and had longer hospital stays. The only ventilatory factor associated with the occurrence of PPCs was the peak pressure. CONCLUSION The incidence of patients with a predicted increased risk of PPCs is high. A large proportion of patients receive high V T and low PEEP levels. PPCs occur frequently in patients at increased risk, with worse clinical outcome.
Published: 2017
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244. Does Cuff Material and Design Help Prevent Ventilator-Associated Pneumonia?

Author: Poelaert, Jan
Published: 2012
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245. Haemodynamics

Author: Poelaert, Jan, primary, Amà, Ruggero, additional, and Skarvan, Karl, additional
Published: 2008
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246. Global Left Ventricular Systolic Function

Author: Schmidt, Christoph, primary, Hinder, Frank, additional, Van Aken, Hugo, additional, and Poelaert, Jan, additional
Published: 2008
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247. Perioperative Transoesophageal Echocardiography

Author: Skarvan, Karl, primary and Poelaert, Jan, additional
Published: 2008
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248. PE62 - The effect of surgical experience on perioperative and oncological outcomes after robot-assisted radical cystectomy with intracorporeal urinary diversion: Evidence from a high-volume center

Author: Dell'Oglio, P., Mazzone, E., Lambert, E., Vollemaere, J., Goossens, M., Larcher, A., Van Der Jeugt, J., De Vos, G., Poelaert, F., Uvin, P., Collins, J., De Naeyer, G., Schatteman, P., D'hondt, F., and Mottrie, A.
Published: 2019
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249. Ventilator-associated Pneumonia and Cuff Shape

Author: Poelaert, Jan
Published: 2011
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250. Exploratory Outlier Detection for Acceleromyographic Neuromuscular Monitoring: Machine Learning Approach (Preprint)

Author: Verdonck, Michaël, primary, Carvalho, Hugo, additional, Berghmans, Johan, additional, Forget, Patrice, additional, and Poelaert, Jan, additional
Published: 2020
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