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8,926 results on '"A. Lando"'

208. High Area Deprivation Index Is Associated With an Increased Risk of Button Battery Ingestion in a Pediatric Cohort

Author

Khan, Aleena, primary, Zhang, Alice, additional, Moscatello, Alessandra, additional, Khandehroo, Bardia, additional, Kahn, Samantha, additional, Cooper, Jaimee, additional, Dominguez, Jose, additional, Vazquez, Sima, additional, Patel, Darshan, additional, Kelley, Ashley, additional, Chan, Kar-Mei, additional, Deserres, Lianne, additional, Lando, Tali, additional, and Salik, Irim, additional

Published
2024
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213. IL1RL1 asthma risk variants regulate airway type 2 inflammation

Author

Gordon, Erin D, Palandra, Joe, Wesolowska-Andersen, Agata, Ringel, Lando, Rios, Cydney L, Lachowicz-Scroggins, Marrah E, Sharp, Louis Z, Everman, Jamie L, MacLeod, Hannah J, Lee, Jae W, Mason, Robert J, Matthay, Michael A, Sheldon, Richard T, Peters, Michael C, Nocka, Karl H, Fahy, John V, and Seibold, Max A

Subjects
Asthma, Genetics, Prevention, Human Genome, Lung, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Cells, Cultured, Genetic Predisposition to Disease, Humans, Inflammation, Interleukin-1 Receptor-Like 1 Protein, Interleukin-33, Polymorphism, Single Nucleotide, Quantitative Trait Loci
Abstract

Genome-wide association studies of asthma have identified genetic variants in the IL1RL1 gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 receptor (ST2L) for IL-33 and an inhibitory decoy receptor (sST2). IL-33 promotes type 2 inflammation, which is present in some but not all asthmatics. We find that two single nucleotide polymorphisms (SNPs) in IL1RL1 - rs1420101 and rs11685480 - are strongly associated with plasma sST2 levels, though neither is an expression quantitative trait locus (eQTL) in whole blood. Rather, rs1420101 and rs11685480 mark eQTLs in airway epithelial cells and distal lung parenchyma, respectively. We find that the genetically determined plasma sST2 reservoir, derived from the lung, neutralizes IL-33 activity, and these eQTL SNPs additively increase the risk of airway type 2 inflammation among asthmatics. These risk variants define a population of asthmatics at risk of IL-33-driven type 2 inflammation.

Published
2016

214. Alternative splicing of interleukin-33 and type 2 inflammation in asthma

Author

Gordon, Erin D, Simpson, Laura J, Rios, Cydney L, Ringel, Lando, Lachowicz-Scroggins, Marrah E, Peters, Michael C, Wesolowska-Andersen, Agata, Gonzalez, Jeanmarie R, MacLeod, Hannah J, Christian, Laura S, Yuan, Shaopeng, Barry, Liam, Woodruff, Prescott G, Ansel, K Mark, Nocka, Karl, Seibold, Max A, and Fahy, John V

Subjects
Genetics, Lung, Asthma, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Adult, Alternative Splicing, Basophils, Cell Line, Epithelial Cells, Female, Gene Expression Profiling, Humans, Inflammation, Interleukin-1 Receptor-Like 1 Protein, Interleukin-33, Male, Mast Cells, Middle Aged, Respiratory Mucosa, Sputum, Young Adult, interleukin-33, alternative splicing, type 2 inflammation, asthma, basophils
Abstract

Type 2 inflammation occurs in a large subgroup of asthmatics, and novel cytokine-directed therapies are being developed to treat this population. In mouse models, interleukin-33 (IL-33) activates lung resident innate lymphoid type 2 cells (ILC2s) to initiate airway type 2 inflammation. In human asthma, which is chronic and difficult to model, the role of IL-33 and the target cells responsible for persistent type 2 inflammation remain undefined. Full-length IL-33 is a nuclear protein and may function as an "alarmin" during cell death, a process that is uncommon in chronic stable asthma. We demonstrate a previously unidentified mechanism of IL-33 activity that involves alternative transcript splicing, which may operate in stable asthma. In human airway epithelial cells, alternative splicing of the IL-33 transcript is consistently present, and the deletion of exons 3 and 4 (Δ exon 3,4) confers cytoplasmic localization and facilitates extracellular secretion, while retaining signaling capacity. In nonexacerbating asthmatics, the expression of Δ exon 3,4 is strongly associated with airway type 2 inflammation, whereas full-length IL-33 is not. To further define the extracellular role of IL-33 in stable asthma, we sought to determine the cellular targets of its activity. Comprehensive flow cytometry and RNA sequencing of sputum cells suggest basophils and mast cells, not ILC2s, are the cellular sources of type 2 cytokines in chronic asthma. We conclude that IL-33 isoforms activate basophils and mast cells to drive type 2 inflammation in chronic stable asthma, and novel IL-33 inhibitors will need to block all biologically active isoforms.

Published
2016

218. Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD

Author

Basu, S., primary, Shukron, O., additional, Hall, D., additional, Parutto, P., additional, Ponjavic, A., additional, Shah, D., additional, Boucher, W., additional, Lando, D., additional, Zhang, W., additional, Reynolds, N., additional, Sober, L. H., additional, Jartseva, A., additional, Ragheb, R., additional, Ma, X., additional, Cramard, J., additional, Floyd, R., additional, Balmer, J., additional, Drury, T. A., additional, Carr, A. R., additional, Needham, L.-M., additional, Aubert, A., additional, Communie, G., additional, Gor, K., additional, Steindel, M., additional, Morey, L., additional, Blanco, E., additional, Bartke, T., additional, Di Croce, L., additional, Berger, I., additional, Schaffitzel, C., additional, Lee, S. F., additional, Stevens, T. J., additional, Klenerman, D., additional, Hendrich, B. D., additional, Holcman, D., additional, and Laue, E. D., additional

Published
2023
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222. Square-free values of polynomials evaluated at primes over a function field

Author

Lando, Guy

Subjects
Mathematics - Number Theory
Abstract

We study a function field version of a classical problem concerning square-free values of polynomials evaluated at primes. We show that for a square-free polynomial $f\in \mathbb{F}_q[t][x]$, there is a limiting density as $n\to \infty$ of primes $P \in \mathbb{F}_q[t]$ of degree $n$ such that $f(P)$ is square-free. Over the integers the analogous result is only known when all irreducible factors of $f$ have degree at most 3.

Published
2014

223. The Stretch - Length Tradeoff in Geometric Networks: Average Case and Worst Case Study

Author

Aldous, David and Lando, Tamar

Subjects
Mathematics - Probability, Computer Science - Computational Geometry
Abstract

Consider a network linking the points of a rate-$1$ Poisson point process on the plane. Write $\Psi^{\mbox{ave}}(s)$ for the minimum possible mean length per unit area of such a network, subject to the constraint that the route-length between every pair of points is at most $s$ times the Euclidean distance. We give upper and lower bounds on the function $\Psi^{\mbox{ave}}(s)$, and on the analogous "worst-case" function $\Psi^{\mbox{worst}}(s)$ where the point configuration is arbitrary subject to average density one per unit area. Our bounds are numerically crude, but raise the question of whether there is an exponent $\alpha$ such that each function has $\Psi(s) \asymp (s-1)^{-\alpha}$ as $s \downarrow 1$., Comment: 33 pages

Published
2014
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234. Design of a Novel Online, Modular, Flipped-classroom Surgical Curriculum for East, Central, and Southern Africa

Author

Parker, Andrea S., Hill, Katherine A., Steffes, Bruce C., Mangaoang, Deirdre, O’Flynn, Eric, Bachheta, Niraj, Bates, Maria F., Bitta, Caesar, Carter, Nicholas H., Davis, Richard E., Dressler, Jeremy A., Eisenhut, Deborah A., Fadipe, Akinniyi E., Kanyi, John K., Kauffmann, Rondi M., Kazal, Frances, Kyamanywa, Patrick, Lando, Justus O., Many, Heath R., Mbithi, Valentine C., McCoy, Amanda J., Meade, Peter C., Ndegwa, Wairimu Y.B., Nkusi, Emmy A., Ooko, Philip B., Osilli, Dixon J.S., Parker, Madison E.D., Rankeeti, Sinkeet, Shafer, Katherine, Smith, James D., Snyder, David, Sylvester, Kimutai R., Wakeley, Michelle E., Wekesa, Marvin K., Torbeck, Laura, White, Russell E., Bekele, Abebe, and Parker, Robert K.

Published
2022
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241. Plasma cell-directed therapy and anti-HLA antibody production: A successful combination?

Author

Soldarini, M, Cafro, A, Bertazzoni, P, Pioltelli, M, Cornacchini, G, Lando, G, Sommaruga, E, Milano, A, Cairoli, R, Rossini, S, Crocchiolo, R, Soldarini, Martina, Cafro, Annamaria, Bertazzoni, Paola, Pioltelli, Marialuisa, Cornacchini, Giorgia, Lando, Giuliana, Sommaruga, Elisabetta, Milano, Antonio, Cairoli, Roberto, Rossini, Silvano, Crocchiolo, Roberto, Soldarini, M, Cafro, A, Bertazzoni, P, Pioltelli, M, Cornacchini, G, Lando, G, Sommaruga, E, Milano, A, Cairoli, R, Rossini, S, Crocchiolo, R, Soldarini, Martina, Cafro, Annamaria, Bertazzoni, Paola, Pioltelli, Marialuisa, Cornacchini, Giorgia, Lando, Giuliana, Sommaruga, Elisabetta, Milano, Antonio, Cairoli, Roberto, Rossini, Silvano, and Crocchiolo, Roberto

Published
2023

244. The stretch-length tradeoff in geometric networks: Average case and worst case study

Author

Aldous, D and Lando, T

Subjects
Pure Mathematics
Abstract

Consider a network linking the points of a rate-1 Poisson point process on the plane. Write Ψave(s) for the minimum possible mean length per unit area of such a network, subject to the constraint that the route-length between every pair of points is at most s times the Euclidean distance. We give upper and lower bounds on the function Ψave(s), and on the analogous worst-case function Ψworst(s) where the point configuration is arbitrary subject to average density one per unit area. Our bounds are numerically crude, but raise the question of whether there is an exponent α such that each function has Ψ(s)(s-1)-α as s ↓ 1.

Published
2015

245. On a weight system conjecturally related to $\mathfrak{sl}_2$

Author

Kulakova, E., Lando, S., Mukhutdinova, T., and Rybnikov, G.

Subjects
Mathematics - Geometric Topology, Mathematics - Combinatorics, 57M25
Abstract

We introduce a new series $R_k$, $k=2,3,4,\dots$, of integer valued weight systems. The value of the weight system $R_k$ on a chord diagram is a signed number of cycles of even length $2k$ in the intersection graph of the diagram. We show that this value depends on the intersection graph only. We check that for small orders of the diagrams, the value of the weight system $R_k$ on a diagram of order exactly $2k$ coincides with the coefficient of $c^k$ in the value of the $\mathfrak{sl}_2$-weight system on the projection of the diagram to primitive elements., Comment: 19 pages, 9 figures; accepted to the European Journal of Combinatorics

Published
2013
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249. Optical and wireless network convergence in 5G systems - an experimental approach.

Author

Paulo Marques 0002, Alexandre Pereira do Carmo, Valerio Frascolla, Carlos F. M. Silva, Emanuel D. R. Sena, Raphael Braga, Joao F. N. Pinheiro, Carlos A. Astudillo, Tiago P. C. de Andrade, Eduardo S. Gama, Luiz F. Bittencourt, Leandro A. Villas, Edmundo R. M. Madeira, Nelson L. S. da Fonseca, Cristiano Both, Gabriel Lando, Matias Artur Klafke Schimuneck, Juliano Araujo Wickboldt, Ana P. V. Trevisan, Rafael de Jesus Martins, Raquel Frizera Vassallo, Felippe Mendonça de Queiroz, Rodolfo Picoreti, Roberta L. Gomes, Cristina K. Dominicini, Victor M. Garcia Martinez, Rafael S. Guimaraes, Rodolfo da Silva Villaça, Magnos Martinello, Moisés R. N. Ribeiro, Daniel F. Macedo, Vinicius F. e Silva, Julio C. T. Guimaraes, Carlos Colman Meixner, Reza Nejabati, Dimitra Simeonidou, Yi Zhang, Frank Slyne, Pedro Alvarez, Diarmuid Collins, Marco Ruffini, Luiz A. DaSilva, and Johann M. Márquez-Barja

Published
2018
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