Search

On the western part of the eastern Indian shield, Archaean basement (Bonai granite) is overlain by radioactive conglomerate. The conglomerate contains well-rounded, fractured Mg-poor (2O3) Zn-rich chromite (>35.0 wt.% Cr2O3) containing up to 15.5 wt.% ZnO. This is the first reported occurrence of detrital zinc-rich chromite having such unusually high ZnO from India, and to our knowledge, the third reported occurrence in radioactive quartz-pebble conglomerate after Witwatersrand, South Africa and Tarkwa, Ghana. Zinc-rich chromite grains are either clean or contain exsolution blebs/lamella of rutile. The conglomerates show evidence for post-depositional hydrothermal fluid influx and fluid-induced mineral alteration. The strong negative correlation between Zn and Fe2+, Al and Cr, and Al and Fe3+, and strong positive correlation between Zn and Al suggest secondary incorporation of Zn and Al by substitution of Fe2+ and Cr (and Fe3+), respectively, leading to partial transformation of (Fe)(Cr,Al,Fe3+)2O4 towards ZnAl2O4 composition. The chromite grains were possibly derived from komatiite. The timing of Zn enrichment, either at the provenance prior to sedimentation, or at the depositional site post-dating sedimentation, remains unresolved.

Background: The virulence of phytophagous insects is predominantly determined by their ability to evade or suppress host defense for their survival. The rice gall midge (GM, Orseolia oryzae), a monophagous pest of rice, elicits a host defense similar to the one elicited upon pathogen attack. This could be due to the GM feeding behaviour, wherein the GM endosymbionts are transferred to the host plant via oral secretions, and as a result, the host mounts an appropriate defense response(s) (i.e., up-regulation of the salicylic acid pathway) against these endosymbionts. Methods: The current study aimed to analyze the microbiome present at the feeding site of GM maggots to determine the exchange of bacterial species between GM and its host and to elucidate their role in rice-GM interaction using a next-generation sequencing approach. Results: Our results revealed differential representation of the phylum Proteobacteria in the GMinfested and -uninfested rice tissues. Furthermore, analysis of the species diversity of Pseudomonas and Wolbachia supergroups at the feeding sites indicated the exchange of bacterial species between GM and its host upon infestation. Conclusion: As rice-GM microbial associations remain relatively unstudied, these findings not only add to our current understanding of microbe-assisted insect-plant interactions but also provide valuable insights into how these bacteria drive insect-plant coevolution. Moreover, to the best of our knowledge, this is the first report analyzing the microbiome of a host plant (rice) at the feeding site of its insect pest (GM).

In this report, we have systematically evaluated the role of boron in regulating the degradation, apatite formation and antibacterial properties of bioactive glasses by substituting SiO2 with B2O3 in S53P4 based glass composition. The structural analysis of the glasses has been carried out using neutron diffraction and Raman spectroscopic techniques. The structural analysis of S53P4 base glass has revealed the presence of silicate and phosphate units in the form of Q2Si, Q3Si and isolated Q0P units. With the increasing replacement of SiO2 with B2O3, Raman spectroscopy revealed the formation of non-ring metaborate units and borate rings consisting of both BO3 and BO4 units at the expense of Q2Si and Q3Si units. Furthermore, DSC, HSM and dilatometry results confirmed that the sinterability parameter (Sc) and fragility index (m) values of borosilicate bioactive glasses help in achieving superior sintering and thermal processing without devitrification. Additionally, in vitro SBF immersion studies revealed an accelerated release of Si4+ and Ca2+ ions from the borosilicate glasses. In vitro antibacterial assays against E.coli bacterial inoculum illustrate the critical role of B2O3 in the bioactive glass composition.

An encapsulation strategy via nano-confinement of a homogeneous manganese–phenanthroline complex into MOF pores selectively produced functionalized branched ketones.

Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin. Recently, substantial advances have been made in applying genetically engineered organoid models to study early tumorigenesis and premalignant biology. These efforts promise to identify novel avenues for early cancer detection, intervention and prevention. Here, we highlight significant advancements in the functional characterization of early genomic and epigenomic events during neoplastic evolution using organoid modeling, discuss the application of the lineage-tracing methodology in organoids to study cancer cells-of-origin, and review future opportunities for further development and improvement of organoid modeling of cancer precursors.

Increase in human population and its need for its lifestyle improvisation leads to nature at risk. One of the natural source on which all live forms depends is water. Water pollution due to non- essential heavy metals is very common. Non- essential heavy metals are very toxic and are threats to human life and other life forms also. Arsenic is one of the non-essential heavy metal which is toxic as well as carcinogenic. Problem due to arsenic pollution is continuously increasing in Asian countries. Arsenic pollution in drinking water along with in paddy fields is global problem all around the world. In almost all regions of West Bengal, India concentration of arsenic in rice continuously increases. Arsenic toxicity is very serious for humans and causes various diseases. Hence, it is necessary to remove arsenic from aqueous solutions to protect human life from its toxic effect. This paper focuses on removal of arsenic using low cost adsorbents through process of biosorption. For removal of arsenic in this study a mixed biosorbent is prepared by mixing roots of Shatavari and Erandmool, leaves of Sadabahar, fruit of Nimbu and panchang of Brahmi. For removal of arsenic ultraviolet spectroscopy method is used here based on the principle of that arsenic when treated with acidified potassium iodate to liberate iodine. The Liberated iodine bleaches the violet colour of azure B which is measured at 644 nm. Results obtained show that maximum percentage of arsenic removal was obtained at 0.5 and 1.0 g of adsorbent dose at 3 mg/l and 5 mg/l of initial arsenic concentration in 3 hour contact time, pH of solution 7 and 8 and 40 rpm agitation speed. Maximum percentage removal obtained at pH 7 by 0.5 g adsorbent dose at 5 mg/l arsenic solution was 82 %. Adsorption isotherm model which supports arsenic removal was Freundlich model whose r2 value obtained was 0.99 and value of n is 1.78 and Kf is 2.53.

Lattice structure, chemical state and magnetic properties in metal doped barium hexaferrite.

Problem definition: The U.S. federal government makes significant investments in technology programs to deliver essential services to the public. The execution of a program is monitored against a baseline—an aggregate plan representing the program’s planned budget, schedule and scope. Recent reports suggest that federal technology programs are re-baselined multiple times, resulting in additional spending of taxpayer money. Although a program’s scope has often been considered a driver of baseline changes, we have a limited understanding of the execution factors that may affect this relationship. Academic/Practical Relevance: With increasing bipartisan scrutiny of federal spending in technology programs and continuing debate in the media about their execution, a nuanced understanding of the drivers of baseline changes in federal technology programs is a critical and contemporary line of inquiry relevant to both policymakers and managers. Our study also responds to recent calls in the operations management literature for research on public sector operations. Methodology: The study sample comprises detailed archival data on 240 U.S. federal government technology programs across 24 federal agencies. We estimate a negative binomial regression specification that accounts for agency fixed effects and several program-specific characteristics to test four hypotheses on the interrelationships between a program’s scope, granularity, management competency, execution methodology and baseline changes.. Results: The results indicate that program scope is positively associated with the number of baseline changes. However, increasing levels of program granularity and program management competency attenuate this positive relationship. Additional analysis highlights the significant savings in taxpayer contributions that can occur by reducing baseline changes in programs of greater scope through an increase in the levels of program granularity and program management competency. Managerial Implications: The study results emphasize the need for federal agencies to invest greater efforts in granularizing a program and in identifying managers with high levels of program management competency when program scope is high, as such efforts can translate into a reduction in the number of baseline changes. The results also highlight the role of number of baseline changes as a valuable in-process metric for program managers and federal agencies to monitor the execution of federal technology programs and identify programs with greater potential. for experiencing cost overruns.

Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight. 5-Aminosalicylates, corticosteroids, immunosuppressive agents and biologics are the backbone of treatment of IBD. With the advent of biologics and small molecules, the need for surgery and hospitalization has decreased. However, economic viability and acceptability is an important determinant of local prescription patterns. Nearly one-third of the patients in West receive biologics as the first/initial therapy. The scenario is different in developing countries where biologics are used only in a small proportion of patients with IBD. Increased risk of reactivation of tuberculosis and high cost of the therapy are limitations to their use. Thiopurines hence become critical for optimal management of patients with IBD in these regions. However, approximately one-third of patients are intolerant or develop adverse effects with their use. This has led to suboptimal use of thiopurines in clinical practice. This review article discusses the clinical aspects of thiopurine use in patients with IBD with the aim of optimizing their use to full therapeutic potential.

Background: Heart failure (HF) affects many patients who are older and frail, presenting multiple physical barriers to accessing specialty care in a traditional ambulatory clinic model. Here, we present an assisted virtual care model in which a home visiting nurse facilitated video visits with a HF cardiologist to follow homebound, frail, and older patients with HF. Methods: This is a pragmatic, quasi-experimental, pre–post, single-centre study. It included homebound, frail, and older patients with HF from 2015 to 2019 who were followed for 1 year; in-person clinic visits were completely replaced by nurse-facilitated virtual video visits. Outcomes evaluated included annualized hospitalization rate, number of hospitalization days, and number of emergency department visits. Results: A total of 49 patients were included, with a median age of 86 (83-93) years, and were followed for 1 year after enrollment. Among patients enrolled, HF with preserved ejection fraction was the most common subtype (57%). Compared to the year prior to enrollment, patients had a lower mortality-adjusted all-cause annualized hospitalization rate in the year following enrollment (2.57 vs 1.78, P < 0.0001). Compared to the year prior, the number of mortality-adjusted all-cause hospitalization days was significantly lower in the year following enrollment (27.2 vs 21.4, P < 0.0001). There was a reduction in the number of all-cause annualized emergency department visits (3.10 vs 2.27, P = 0.003). Conclusions: Nurse-assisted virtual visits may be a preferable strategy for homebound, frail, and older patients with HF to receive longitudinal care. This approach may represent a plausible strategy to care for other patients with significant barriers to accessing specialized cardiac care. Résumé: Contexte: L’insuffisance cardiaque (IC) touche de nombreux patients âgés et fragiles, et dresse maints obstacles physiques à l’accès aux soins spécialisés au sein d’un modèle classique de soins cliniques ambulatoires. Dans le présent article, nous exposons un modèle de soins virtuels assistés où une infirmière visiteuse assure par vidéoconsultation, avec un cardiologue, le suivi de patients âgés et fragiles atteints d’IC confinés à la maison. Méthodologie: Une étude monocentrique et pragmatique, quasi expérimentale de type « avant-après », a été menée de 2015 à 2019 auprès de patients âgés et fragiles atteints d’IC confinés à la maison. Les patients ont été suivis durant un an; les consultations en personne ont été entièrement remplacées par des vidéoconsultations effectuées par une infirmière. Les paramètres évalués comprenaient le taux annualisé d’hospitalisation, le nombre de jours d’hospitalisation et le nombre de consultations aux urgences. Résultats: Au total, 49 patients dont l’âge médian était de 86 ans (83-93 ans) ont été suivis durant un an à compter de leur admission à l’étude. L’IC à fraction d’éjection préservée était le sous-type d’IC le plus fréquent (57 %) chez les patients participant à l’étude. Par comparaison à l’année précédente, le taux annualisé d’hospitalisation toutes causes confondues ajusté en fonction de la mortalité a été plus faible chez les patients au cours de l’année où ils ont été suivis dans le cadre de l’étude (2,57 vs 1,78, P < 0,0001). Toujours par comparaison à l’année précédente, le nombre de jours d’hospitalisation toutes causes confondues ajusté en fonction de la mortalité a été significativement inférieur chez les patients au cours de l’année où ils ont été suivis dans le cadre de l’étude (27,2 vs 21,4, P < 0,0001). Le nombre annualisé de consultations aux urgences toutes causes confondues a quant à lui diminué (3,10 vs 2,27, P = 0,003). Conclusions: Les consultations virtuelles assistées par une infirmière peuvent constituer une stratégie à privilégier dans la prestation de soins longitudinaux à des patients âgés et fragiles atteints d’IC qui sont confinés à la maison. Cette approche pourrait représenter une stratégie plausible pour prodiguer des soins à d’autres patients qui sont confrontés à d’importants obstacles limitant leur accès à des soins spécialisés en cardiologie.

Supplementary Figure 4 from Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in Leukemogenesis

Supplementary Figure 5 from Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in Leukemogenesis

Supplementary Figure 2 from Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in Leukemogenesis

Supplementary Figure 3 from Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in Leukemogenesis

Supplementary Figure 1 from Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in Leukemogenesis

Recurring chromosomal translocations observed in human leukemia often result in the expression of fusion proteins that are DNA-binding transcription factors. These altered proteins acquire new dimerization properties that result in the assembly of inappropriate multimeric transcription complexes that deregulate hematopoietic programs and induce leukemogenesis. Recently, we reported that the fusion protein AML1/MDS1/EVI1 (AME), a product of a t(3;21)(q26;q22) associated with chronic myelogenous leukemia and acute myelogenous leukemia, displays a complex pattern of self-interaction. Here, we show that the 8th zinc finger motif of MDS1/EVI1 is an oligomerization domain involved not only in interaction of AME with itself but also in interactions with the parental proteins, RUNX1 and MDS1/EVI1, from which AME is generated. Because the 8th zinc finger motif is also present in the oncoprotein EVI1, we have evaluated the effects of the interaction between RUNX1 and EVI1 in vitro and in vivo. We found that in vitro, this interaction alters the ability of RUNX1 to bind to DNA and to regulate a reporter gene, whereas in vivo, the expression of the isolated 8th zinc finger motif of EVI1 is sufficient to block the granulocyte colony-stimulating factor–induced differentiation of 32Dcl3 cells, leading to cell death. As EVI1 is not detected in normal bone marrow cells, these data suggest that its inappropriate expression could contribute to hematopoietic transformation in part by a new mechanism that involves EVI1 association with key hematopoietic regulators, leading to their functional impairment. [Cancer Res 2007;67(12):5658–66]

The stimulated-emission-pumping/resonant 2-photon ionization (SEP-R2PI) method was used to determine the intermolecular ground-state dissociation energies, D0(S0) of jet-cooled complexes of 1- naphthol (1NpOH) with ethene, trans-1,2-dichloroethene, trichloroethene and tetrachloroethene. UV/UV holeburning measurements revealed a single isomer for the ethene and tetrachloroethene complexes, two isomers (A, B) for the trans-1,2-dichloroethene and four for the trichloroethene complex. The D0(S0) of 1-naphtholethene was measured to be 13.370.29 kJ/mol, those of 1NpOHtrans-1,2-dichloroethene are 21.990.10 kJ/mol for isomer A and 21.940.07 kJ/mol for isomer B. That of 1-naphtholtrichloroethene (isomer A) is 25.680.24 kJ/mol, and that of 1- naphtholtetrachloroethene is 26.700.39 kJ/mol. Calculations of the same complexes were carried out with the dispersion-corrected density functional methods B97-D3, B3LYP-D3 and B97xD. The ethene complex is predicted to have an Edge geometry, with the naphthol -OH group forming a hydrogen bond to the ethene C=C double bond. The polychloroethene complexes are predicted to have Face structures, with the admolecule adsorbed onto the naphthalene aromatic ring. All three DFT-D methods predict minimum-energy structures with the plane of the chloroethene tilted away from the plane of the naphthalene moiety.

An efficient dual Pd-catalytic system was developed for one-pot synthesis of 3-sulfenylindoles via C–C, C–N and C–S bond construction directly from unactivated 2-iodo(NH)anilines under mild reaction conditions.