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201. Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period

Author: Caroline Frørup, Aashiq H. Mirza, Reza Yarani, Lotte B. Nielsen, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Christian Engelbrekt, Joachim Størling, Jesper Johannesen, Henrik B. Mortensen, Flemming Pociot, and Simranjeet Kaur
Subjects: Adult, type 1 diabetes, Immunology, Mothers, exosomes, Biology, Exosome, Andrology, SDG 3 - Good Health and Well-being, Downregulation and upregulation, Pregnancy, Diabetes mellitus, microRNA, medicine, Humans, Immunology and Allergy, Circulating MicroRNA, small RNA-Seq, plasma, Original Research, Type 1 diabetes, Pancreatic islets, Postpartum Period, RC581-607, medicine.disease, Microvesicles, Breast Feeding, Diabetes Mellitus, Type 1, medicine.anatomical_structure, miRNAs, Female, Immunologic diseases. Allergy, extracellular vesicles, Biomarkers, Postpartum period
Abstract: Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction. Several studies have highlighted the implication of circulating and exosomal microRNAs (miRNAs) in type 1 diabetes, underlining its biomarker value and novel therapeutic potential. Recently, we discovered that exosome-enriched extracellular vesicles carry altered levels of both known and novel miRNAs in breast milk from lactating mothers with type 1 diabetes. In this study, we aimed to characterize exosomal miRNAs in the circulation of lactating mothers with and without type 1 diabetes, hypothesizing that differences in type 1 diabetes risk in offspring from these groups are reflected in the circulating miRNA profile. We performed small RNA sequencing on exosome-enriched extracellular vesicles extracted from plasma of 52 lactating mothers around 5 weeks postpartum (26 with type 1 diabetes and 26 age-matched controls), and found a total of 2,289 miRNAs in vesicles from type 1 diabetes and control libraries. Of these, 176 were differentially expressed in plasma from mothers with type 1 diabetes (167 upregulated; 9 downregulated, using a cut-off of abs(log2FC) >1 and FDR adjusted p-value
Published: 2021

202. Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT

Author: Ailin Falkmo Hansen, Amy M. Mason, Ketil Thorstensen, Sarah E. Graham, Kristian Hveem, Cristen J. Willer, Dipender Gill, Ben Michael Brumpton, Bjørn Olav Åsvold, Sarah A Gagliano Taliun, Jonas B. Nielsen, David Schlessinger, Lars G. Fritsche, Francesco Cucca, Stephen Burgess, Marta R Moksnes, Kuan-Han Wu, Wei Zhou, and Gonçalo R. Abecasis
Subjects: Genetics, chemistry.chemical_classification, medicine.diagnostic_test, Transferrin saturation, Iron deficiency, Biology, medicine.disease, chemistry, Total iron-binding capacity, Transferrin, Mendelian randomization, medicine, Serum iron, Biomarker (medicine), Genetic association
Abstract: Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron related biomarkers (serum iron, serum ferritin, transferrin saturation, total iron binding capacity) in the Trøndelag Health Study (HUNT), the Michigan Genomics Initiative (MGI) and the SardiNIA study, followed by their meta-analysis with publicly available summary statistics, analyzing up to 257 953 individuals. We identify 127 genetic loci associated with iron traits. Among 19 novel protein-altering variants, we observe a rare missense variant (rs367731784) in HUNT, which suggests a role for DNAJC13 in transferrin recycling. We further validate the latest genetic risk scores for each biomarker in HUNT (6% variance in serum iron explained) and present linear and non-linear Mendelian randomization analyses of the traits on all-cause mortality. We find evidence of a harmful effect of increased serum iron and transferrin saturation in linear analyses that estimate population-averaged effects. However, there was weak evidence of a protective effect of increasing serum iron at the very low end of its distribution. Our findings contribute to our understanding of the genes affecting iron status and its consequences on human health.
Published: 2021

203. Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT

Author: Marta R, Moksnes, Sarah E, Graham, Kuan-Han, Wu, Ailin Falkmo, Hansen, Sarah A, Gagliano Taliun, Wei, Zhou, Ketil, Thorstensen, Lars G, Fritsche, Dipender, Gill, Amy, Mason, Francesco, Cucca, David, Schlessinger, Gonçalo R, Abecasis, Stephen, Burgess, Bjørn Olav, Åsvold, Jonas B, Nielsen, Kristian, Hveem, Cristen J, Willer, and Ben M, Brumpton
Subjects: Iron, Ferritins, Transferrin, Humans, Polymorphism, Single Nucleotide, Biomarkers, Genome-Wide Association Study
Abstract: Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron-related biomarkers (serum iron, serum ferritin, transferrin saturation, total iron-binding capacity) in the Trøndelag Health Study (HUNT), the Michigan Genomics Initiative (MGI), and the SardiNIA study, followed by their meta-analysis with publicly available summary statistics, analyzing up to 257,953 individuals. We identify 123 genetic loci associated with iron traits. Among 19 novel protein-altering variants, we observe a rare missense variant (rs367731784) in HUNT, which suggests a role for DNAJC13 in transferrin recycling. We further validate recently published results using genetic risk scores for each biomarker in HUNT (6% variance in serum iron explained) and present linear and non-linear Mendelian randomization analyses of the traits on all-cause mortality. We find evidence of a harmful effect of increased serum iron and transferrin saturation in linear analyses that estimate population-averaged effects. However, there was weak evidence of a protective effect of increasing serum iron at the very low end of its distribution. Our findings contribute to our understanding of the genes affecting iron status and its consequences on human health.
Published: 2021

204. Monoclonal Antibody Therapy against Acinetobacter baumannii

Author: Travis B. Nielsen, Elizabeth Burk, Brian Luna, Matthew Slarve, Peter Oelschlaeger, William Win, Kyle Hurth, Robert A. Bonomo, Yuli Talyansky, Rachel Li, Bosul Lee, Peggy Lu, Brad Spellberg, Juan Ruiz, and Jun Yan
Subjects: Acinetobacter baumannii, medicine.drug_class, Immunology, Antibiotics, Microbial Sensitivity Tests, Monoclonal antibody, Microbiology, Sepsis, Mice, Drug Resistance, Multiple, Bacterial, medicine, Animals, Monoclonal antibody therapy, biology, Colistin, Antibodies, Monoclonal, biology.organism_classification, medicine.disease, Antibodies, Bacterial, Anti-Bacterial Agents, Infectious Diseases, Microbial Immunity and Vaccines, biology.protein, Hybridoma technology, Cytokines, Parasitology, Antibody, Biomarkers, medicine.drug, Acinetobacter Infections
Abstract: Extremely drug-resistant (XDR) Acinetobacter baumannii is a notorious and frequently encountered pathogen demanding novel therapeutic interventions. An initial monoclonal antibody (MAb), C8, raised against A. baumannii capsule, proved a highly effective treatment against a minority of clinical isolates. To overcome this limitation, we broadened coverage by developing a second antibody for use in a combination regimen. We sought to develop an additional anti-A. baumannii MAb through hybridoma technology by immunizing mice with sublethal inocula of virulent, XDR clinical isolates not bound by MAb C8. We identified a new antibacterial MAb, 65, which bound to strains in a pattern distinct from and complementary to that of MAb C8. MAb 65 enhanced macrophage opsonophagocytosis of targeted strains and markedly improved survival in lethal bacteremic sepsis and aspiration pneumonia murine models of A. baumannii infection. MAb 65 was also synergistic with colistin, substantially enhancing protection compared to monotherapy. Treatment with MAb 65 significantly reduced blood bacterial density, ameliorated cytokine production (interleukin-1β [IL-1β], IL-6, IL-10, and tumor necrosis factor), and sepsis biomarkers. We describe a novel MAb targeting A. baumannii that broadens immunotherapeutic strain coverage, is highly potent and effective, and synergistically improves outcomes in combination with antibiotics.
Published: 2021

205. Mixed Ionic and Electronic Conduction in Small-Molecule Semiconductors

Author: Christina J. Kousseff, Christian B. Nielsen, Zachary S. Parr, and Roman Halaksa
Subjects: Bioelectronics, business.industry, Chemistry, Transistor, Ionic bonding, Nanotechnology, Context (language use), 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, law.invention, Organic semiconductor, Semiconductor, Semiconductors, law, Electronics, 0210 nano-technology, business, Electrical conductor, Organic electrochemical transistor
Abstract: Small-molecule organic semiconductors have displayed remarkable electronic properties with a multitude of π-conjugated structures developed and fine-tuned over recent years to afford highly efficient hole- and electron-transporting materials. Already making a significant impact on organic electronic applications including organic field-effect transistors and solar cells, this class of materials is also now naturally being considered for the emerging field of organic bioelectronics. In efforts aimed at identifying and developing (semi)conducting materials for bioelectronic applications, particular attention has been placed on materials displaying mixed ionic and electronic conduction to interface efficiently with the inherently ionic biological world. Such mixed conductors are conveniently evaluated using an organic electrochemical transistor, which further presents itself as an ideal bioelectronic device for transducing biological signals into electrical signals. Here, we review recent literature relevant for the design of small-molecule mixed ionic and electronic conductors. We assess important classes of p- and n-type small-molecule semiconductors, consider structural modifications relevant for mixed conduction and for specific interactions with ionic species, and discuss the outlook of small-molecule semiconductors in the context of organic bioelectronics.
Published: 2021

206. Squeezing anyons for braiding on small lattices

Author: N. S. Srivatsa, Xikun Li, and Anne E. B. Nielsen
Subjects: Physics, Toy model, Strongly Correlated Electrons (cond-mat.str-el), Anyon, FOS: Physical sciences, Charge (physics), Ultracold matter, Quantum Hall effect, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Topological quantum computer, STATISTICS, Condensed Matter - Strongly Correlated Electrons, High Energy Physics::Theory, Quantum state, Lattice (order), Statistical physics, Adiabatic process, QUANTUM
Abstract: Adiabatically exchanging anyons gives rise to topologically protected operations on the quantum state of the system, but the desired result is only achieved if the anyons are well separated, which requires a sufficiently large area. Being able to reduce the area needed for the exchange, however, would have several advantages, such as enabling a larger number of operations per area and allowing anyon exchange to be studied in smaller systems that are easier to handle. Here, we use optimization techniques to squeeze the charge distribution of Abelian anyons in lattice fractional quantum Hall models, and we show that the squeezed anyons can be exchanged within a smaller area with a close to ideal outcome. We first use a toy model consisting of a modified Laughlin trial state to show that one can shape the anyons without altering the exchange statistics under certain conditions. We then squeeze and braid anyons in the Kapit-Mueller model and an interacting Hofstadter model by adding suitable potentials. We consider a fixed system size, for which the charge distributions of the normal anyons overlap, and we find that the outcome of the exchange process is closer to the ideal value for the squeezed anyons. The time needed for the exchange is also important, and for a particular example we find that the duration needed for the process to be close to the adiabatic limit is about five times longer for the squeezed anyons when the path length is the same. Finally we show that the exchange outcome is robust with respect to small modifications of the potential away from the optimized value., Comment: 9 pages, 4 figures, 1 movie
Published: 2021

207. Clinically decisive (dis)agreement in multidisciplinary team assessment of esophageal squamous cell carcinoma; a prospective, national, multicenter study

Author: August A Olsen, Niels Katballe, Marianne Nordsmark, Stine Kramer, Alan Patrick Ainsworth, Daniel Kjær, Lene Baeksgaard, Morten Ladekarl, Thomas S. Kristensen, Michael Larsen, Jens Eckardt, C D Lütken, Annika Loft, Rune Vincents Fisker, S Schlander, Eva Holtved, Elizaveta Mitkina Tabaksblat, M. B. Nielsen, Sönke Detlefsen, G Naujokaite, I Kruhlikava, S Dikinis, Rajendra Singh Garbyal, Peter Brøndum Mortensen, Michael Patrick Achiam, and Mette Siemsen
Subjects: medicine.medical_specialty, Operability, Esophageal Neoplasms, SURGERY, Interobserver agreement, Esophageal cancer, Esophageal Neoplasms/therapy, Multidisciplinary team, Esophageal squamous cell carcinoma, medicine, Upper gastrointestinal, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Prospective cohort study, Patient Care Team, OUTCOMES, upper gastrointestinal cancer, business.industry, Cancer, Hematology, General Medicine, medicine.disease, CANCER, Oncology, Multicenter study, Head and Neck Neoplasms, Radiology, Esophageal Squamous Cell Carcinoma, business, multidisciplinary team (MDT)
Abstract: BACKGROUND: Decisions regarding tumor staging, operability, resectability, and treatment strategy in patients with esophageal cancer are made at multidisciplinary team (MDT) conferences. We aimed to assess interobserver agreement from four national MDT conferences and whether this would have a clinical impact.METHODS: A total of 20 patients with esophageal cancer were included across all four upper gastrointestinal (GI) cancer centers. Fully anonymized patient data were distributed among the MDT conferences which decided on TNM category, resectability, operability, curability, and treatment strategy blinded to each other's decisions. The interobserver agreement was expressed as both the raw observer agreement and with Krippendorff's α values. Finally, a case-by-case evaluation was performed to determine if disagreement would have had a clinical impact.RESULTS: A total of 80 MDT evaluations were available for analysis. A moderate to near-perfect observer agreement of 79.2%, 55.8%, and 82.5% for TNM category was observed, respectively. Substantial agreement for resectability and moderate agreement for curability were found. However, an only fair agreement was observed for the operability category. The treatment strategies had a slight agreement which corresponded to disagreement having a clinical impact in 12 patients.CONCLUSIONS: Esophageal cancer MDT conferences had an acceptable interobserver agreement on resectability and TM categories; however, the operability assessment had a high level of disagreement. Consequently, the agreement on treatment strategy was reduced with a potential clinical impact. In future MDT conferences, emphasis should be on prioritizing the relevant information being readily available (operability, T & M categories) to minimize the risk of disagreement in the assessments and treatment strategies, and thus, delayed or suboptimal treatment.
Published: 2021

208. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Author: Steinunn Thordardottir, Kristian Hveem, Per Selnes, Silke Kern, Wei Zhou, Srdjan Djurovic, Iris E. Jansen, Ole A. Andreassen, Petroula Proitsi, Linda M. Pedersen, Tormod Fladby, Tore Wergeland Meisingset, Chandra A. Reynolds, Angela Hodges, Ingmar Skoog, Alexey A. Shadrin, Bendik S. Winsvold, Margda Waern, Geir Bråthen, Danielle Posthuma, Lavinia Athanasiu, Richard Dobson, Adam Auton, Shahram Bahrami, Anna Zettergren, Maiken Elvestad Gabrielsen, Henrik Zetterberg, Eystein Stordal, Geir Selbæk, John-Anker Zwart, Laurent F. Thomas, Amy E Martinsen, Ingun Ulstein, Jonas B. Nielsen, Kari Stefansson, Ole Kristian Drange, Arvid Rongve, Anne Heidi Skogholt, Julia M. Sealock, Sigrid Botne Sando, Palmi V. Jonsson, Jon Snaedal, Kaj Blennow, Ingvild Saltvedt, Lars G. Fritsche, Karl Heilbron, Jeanne E. Savage, Sigurdur H. Magnusson, Ingunn Bosnes, Stephan Ripke, Marianne Bakke Johnsen, Ida K. Karlsson, Lea K. Davis, Latha Velayudhan, Nancy L. Pedersen, Dag Aarsland, Cristen J. Willer, Hreinn Stefansson, Dominic Holland, Sigrid Børte, Douglas P Wightman, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, and Complex Trait Genetics
Subjects: Genetics, Microglia, Polygenic disease, Genome-wide association study, Disease, Biology, medicine.disease, Article, medicine.anatomical_structure, Immune system, SDG 3 - Good Health and Well-being, Polymorphism (computer science), medicine, Dementia, Gene
Abstract: Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer’s disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer’s disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer’s disease to identify further genetic variants that contribute to Alzheimer’s pathology.
Published: 2021

209. Restricted Variance Interactions in Entrepreneurship Research: A Unique Basis for Context-as-Moderator Hypotheses

Author: Jose M. Cortina, Tine Köhler, Zitong Sheng, Kathleen R. Keeler, Bo B. Nielsen, Joseph E. Coombs, and David J. Ketchen
Subjects: Economics and Econometrics, Business and International Management
Abstract: In this methodological brief, we demonstrate the usefulness of the restricted variance (RV) interaction to entrepreneurship research. RV reasoning can help scholars to specify precise roles for contextual moderators. This specificity allows for strengthening of arguments and for testing of one of the reasons for an interaction. In some cases, it points to otherwise unexpected interaction patterns. We illustrate the power of RV reasoning with a data set of 503 biotech firms to show how RV explains geographic differences in the relationship between number of alliances and initial public offering value. Finally, we show how these interactions can be tested given typical distributions.
Published: 2022

210. Role of oxygen within end group substituents on film morphology and charge carrier transport in thiophene/phenylene small-molecule semiconductors

Author: Witold Waliszewski, Zachary S. Parr, Agnieszka Michalska, Roman Halaksa, Hanna Zajaczkowska, Piotr Sleczkowski, Marios Neophytou, Beata Luszczynska, Paul W.M. Blom, Christian B. Nielsen, Tomasz Marszalek, and Wojciech Pisula
Subjects: Biomaterials, Materials Chemistry, General Chemistry, Electrical and Electronic Engineering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials
Published: 2022

211. 6 Decline in HbA1c during the first year on elexacaftor/tezacaftor/ivacaftor in the Danish cystic fibrosis population

Author: B. Nielsen, M. Olsen, I. Mathiesen, T. Pressler, S. Jensen-Fangel, C. Ritz, T. Almdal, and D. Faurholt-Jepsen
Subjects: Pulmonary and Respiratory Medicine, Pediatrics, Perinatology and Child Health
Published: 2022

212. Correction to 'Global Shipping Emissions from a Well-to-Wake Perspective: The MariTEAM Model'

Author: Diogo Kramel, Helene Muri, YoungRong Kim, Radek Lonka, Jørgen B. Nielsen, Anna L. Ringvold, Evert A. Bouman, Sverre Steen, and Anders H. Strømman
Subjects: Environmental Chemistry, General Chemistry
Published: 2022

213. Results of the deepest all-sky survey for continuous gravitational waves on LIGO S6 data running on the Einstein@Home volunteer distributed computing project

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. Bacon, M. K. M. Bader, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, M. Bejger, A. S. Bell, B. K. Berger, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, M. Boer, G. Bogaert, C. Bogan, A. Bohe, C. Bond, F. Bondu, R. Bonnand, B. A. Boom, R. Bork, V. Boschi, S. Bose, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, J. E. Broida, A. F. Brooks, D. A. Brown, D. D. Brown, N. M. Brown, S. Brunett, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. Callister, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, C. B. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. Chassande-Mottin, B. D. Cheeseboro, H. Y. Chen, Y. Chen, C. Cheng, A. Chincarini, A. Chiummo, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, S. Chua, S. Chung, G. Ciani, F. Clara, J. A. Clark, F. Cleva, E. Coccia, P.-F. Cohadon, A. Colla, C. G. Collette, L. Cominsky, M. Constancio, A. Conte, L. Conti, D. Cook, T. R. Corbitt, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, K. Craig, J. D. E. Creighton, T. D. Creighton, J. Cripe, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, S. L. Danilishin, S. D’Antonio, K. Danzmann, N. S. Darman, A. Dasgupta, C. F. Da Silva Costa, V. Dattilo, I. Dave, M. Davier, G. S. Davies, E. J. Daw, R. Day, S. De, D. DeBra, G. Debreczeni, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, T. Denker, T. Dent, V. Dergachev, R. De Rosa, R. T. DeRosa, R. DeSalvo, R. C. Devine, S. Dhurandhar, M. C. Díaz, L. Di Fiore, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, S. Di Pace, I. Di Palma, A. Di Virgilio, V. Dolique, F. Donovan, K. L. Dooley, S. Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. Eichholz, S. S. Eikenberry, W. Engels, R. C. Essick, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, H. Fair, S. Fairhurst, X. Fan, Q. Fang, S. Farinon, B. Farr, W. M. Farr, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, E. Fenyvesi, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, D. Fiorucci, R. P. Fisher, R. Flaminio, M. Fletcher, J.-D. Fournier, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, G. Gaur, N. Gehrels, G. Gemme, P. Geng, E. Genin, A. Gennai, J. George, L. Gergely, V. Germain, Abhirup Ghosh, Archisman Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, A. Glaefke, E. Goetz, R. Goetz, L. Gondan, G. González, J. M. Gonzalez Castro, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, R. Gouaty, A. Grado, C. Graef, P. B. Graff, M. Granata, A. Grant, S. Gras, C. Gray, G. Greco, A. C. Green, P. Groot, H. Grote, S. Grunewald, G. M. Guidi, X. Guo, A. Gupta, M. K. Gupta, K. E. Gushwa, E. K. Gustafson, R. Gustafson, J. J. Hacker, B. R. Hall, E. D. Hall, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, J. Hanson, T. Hardwick, J. Harms, G. M. Harry, I. W. Harry, M. J. Hart, M. T. Hartman, C.-J. Haster, K. Haughian, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, J. Henry, A. W. Heptonstall, M. Heurs, S. Hild, D. Hoak, D. Hofman, K. Holt, D. E. Holz, P. Hopkins, J. Hough, E. A. Houston, E. J. Howell, Y. M. Hu, S. Huang, E. A. Huerta, D. Huet, B. Hughey, S. Husa, S. H. Huttner, T. Huynh-Dinh, N. Indik, D. R. Ingram, R. Inta, H. N. Isa, J.-M. Isac, M. Isi, T. Isogai, B. R. Iyer, K. Izumi, T. Jacqmin, H. Jang, K. Jani, P. Jaranowski, S. Jawahar, L. Jian, F. Jiménez-Forteza, W. W. Johnson, D. I. Jones, R. Jones, R. J. G. Jonker, L. Ju, Haris K, C. V. Kalaghatgi, V. Kalogera, S. Kandhasamy, G. Kang, J. B. Kanner, S. J. Kapadia, S. Karki, K. S. Karvinen, M. Kasprzack, E. Katsavounidis, W. Katzman, S. Kaufer, T. Kaur, K. Kawabe, F. Kéfélian, M. S. Kehl, D. Keitel, D. B. Kelley, W. Kells, R. Kennedy, J. S. Key, F. Y. Khalili, I. Khan, S. Khan, Z. Khan, E. A. Khazanov, N. Kijbunchoo, Chi-Woong Kim, Chunglee Kim, J. Kim, K. Kim, N. Kim, W. Kim, Y.-M. Kim, S. J. Kimbrell, E. J. King, P. J. King, J. S. Kissel, B. Klein, L. Kleybolte, S. Klimenko, S. M. Koehlenbeck, S. Koley, V. Kondrashov, A. Kontos, M. Korobko, W. Z. Korth, I. Kowalska, D. B. Kozak, V. Kringel, B. Krishnan, A. Królak, C. Krueger, G. Kuehn, P. Kumar, R. Kumar, L. Kuo, A. Kutynia, B. D. Lackey, M. Landry, J. Lange, B. Lantz, P. D. Lasky, M. Laxen, C. 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Zevin, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, Z. Zhou, S. J. Zhu, X. Zhu, M. E. Zucker, S. E. Zuraw, and J. Zweizig
Published: 2016
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214. Directly comparing GW150914 with numerical solutions of Einstein’s equations for binary black hole coalescence

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. Bacon, M. K. M. Bader, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, M. Bejger, A. S. Bell, B. K. Berger, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. 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Published: 2016
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215. Search for transient gravitational waves in coincidence with short-duration radio transients during 2007–2013

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. Bacon, M. K. M. Bader, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, B. Behnke, M. Bejger, A. S. Bell, C. J. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, C. Bogan, A. Bohe, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, B. A. Boom, R. Bork, V. Boschi, S. Bose, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. Callister, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, C. B. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, T. Chalermsongsak, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. 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Radkins, P. Raffai, S. Raja, M. Rakhmanov, P. Rapagnani, V. Raymond, M. Razzano, V. Re, J. Read, C. M. Reed, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, H. Rew, F. Ricci, K. Riles, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, J. D. Romano, R. Romano, G. Romanov, J. H. Romie, D. Rosińska, S. Rowan, A. Rüdiger, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, L. Sadeghian, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, L. Sammut, E. J. Sanchez, V. Sandberg, B. Sandeen, J. R. Sanders, B. Sassolas, B. S. Sathyaprakash, P. R. Saulson, O. E. S. Sauter, R. L. Savage, A. Sawadsky, P. Schale, R. Schilling, J. Schmidt, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, D. Schuette, B. F. Schutz, J. Scott, S. M. Scott, D. Sellers, D. Sentenac, V. Sequino, A. Sergeev, G. Serna, Y. Setyawati, A. Sevigny, D. A. Shaddock, M. S. Shahriar, M. Shaltev, Z. Shao, B. Shapiro, P. Shawhan, A. Sheperd, D. H. Shoemaker, D. M. Shoemaker, K. Siellez, X. Siemens, M. Sieniawska, D. Sigg, A. D. Silva, D. Simakov, A. Singer, L. P. Singer, A. Singh, R. Singh, A. Singhal, A. M. Sintes, B. J. J. Slagmolen, J. R. Smith, N. D. Smith, R. J. E. Smith, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, A. K. Srivastava, A. Staley, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, B. C. Stephens, D. Stiles, R. Stone, K. A. Strain, N. Straniero, G. Stratta, N. A. Strauss, S. Strigin, R. Sturani, A. L. Stuver, T. Z. Summerscales, L. Sun, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, D. Talukder, D. B. Tanner, M. Tápai, S. P. Tarabrin, A. Taracchini, R. Taylor, T. Theeg, M. P. Thirugnanasambandam, E. G. Thomas, M. Thomas, P. Thomas, K. A. Thorne, E. Thrane, S. Tiwari, V. Tiwari, K. V. Tokmakov, C. Tomlinson, M. Tonelli, C. V. Torres, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, D. Trifirò, M. C. Tringali, L. Trozzo, M. Tse, M. Turconi, D. Tuyenbayev, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. van Heijningen, A. A. van Veggel, M. Vardaro, S. Vass, M. Vasúth, R. Vaulin, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, D. Verkindt, F. Vetrano, A. Viceré, S. Vinciguerra, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, D. V. Voss, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, Y. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, T. Westphal, K. Wette, J. T. Whelan, S. E. Whitcomb, D. J. White, B. F. Whiting, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Worden, J. L. Wright, G. Wu, J. Yablon, W. Yam, H. Yamamoto, C. C. Yancey, M. J. Yap, H. Yu, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, M. Zevin, F. Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, J. Zweizig, A. M. Archibald, S. Banaszak, A. Berndsen, J. Boyles, R. F. Cardoso, P. Chawla, A. Cherry, L. P. Dartez, D. Day, C. R. Epstein, A. J. Ford, J. Flanigan, A. Garcia, J. W. T. Hessels, J. Hinojosa, F. A. Jenet, C. Karako-Argaman, V. M. Kaspi, E. F. Keane, V. I. Kondratiev, M. Kramer, S. Leake, D. Lorimer, G. Lunsford, R. S. Lynch, J. G. Martinez, A. Mata, M. A. McLaughlin, C. A. McPhee, T. Penucci, S. Ransom, M. S. E. Roberts, M. D. W. Rohr, I. H. Stairs, K. Stovall, J. van Leeuwen, A. N. Walker, and B. L. Wells
Published: 2016
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216. Properties of the Binary Black Hole Merger GW150914

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. Bacon, M. K. M. Bader, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, B. Behnke, M. Bejger, A. S. Bell, C. J. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, O. Birnholtz, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, C. Bogan, A. Bohe, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, B. A. Boom, R. Bork, V. Boschi, S. Bose, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. Callister, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, C. B. Cepeda, L. Carbon Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, T. Chalermsongsak, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. Chassande-Mottin, H. Y. Chen, Y. Chen, C. Cheng, A. Chincarini, A. Chiummo, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, S. Chua, S. Chung, G. Ciani, F. Clara, J. A. Clark, F. Cleva, E. Coccia, P.-F. Cohadon, A. Colla, C. G. Collette, L. Cominsky, M. Constancio, A. Conte, L. Conti, D. Cook, T. R. Corbitt, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, K. Craig, J. D. E. Creighton, J. Cripe, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, S. L. Danilishin, S. D’Antonio, K. Danzmann, N. S. Darman, V. Dattilo, I. Dave, H. P. Daveloza, M. Davier, G. S. Davies, E. J. Daw, R. Day, D. DeBra, G. Debreczeni, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, T. Denker, T. Dent, H. Dereli, V. Dergachev, R. De Rosa, R. T. DeRosa, R. DeSalvo, C. Devine, S. Dhurandhar, M. C. Díaz, L. Di Fiore, M. Di Giovanni, A. Di Lieto, S. Di Pace, I. Di Palma, A. Di Virgilio, G. Dojcinoski, V. Dolique, F. Donovan, K. L. Dooley, S. Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, Z. Du, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. Eichholz, S. S. Eikenberry, W. Engels, R. C. Essick, Z. Etienne, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, H. Fair, S. Fairhurst, X. Fan, Q. Fang, S. Farinon, B. Farr, W. M. Farr, E. Fauchon-Jones, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, D. Fiorucci, R. P. Fisher, R. Flaminio, M. Fletcher, J.-D. Fournier, S. Franco, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, T. T. Fricke, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, S. M. Gaebel, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, A. Gatto, G. Gaur, N. Gehrels, G. Gemme, B. Gendre, E. Genin, A. Gennai, J. George, L. Gergely, V. Germain, Archisman Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, A. Glaefke, E. Goetz, R. Goetz, L. Gondan, G. González, J. M. Gonzalez Castro, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, R. Gouaty, C. Graef, P. B. Graff, M. Granata, A. Grant, S. Gras, C. Gray, G. Greco, A. C. Green, P. Groot, H. Grote, S. Grunewald, G. M. Guidi, X. Guo, A. Gupta, M. K. Gupta, K. E. Gushwa, E. K. Gustafson, R. Gustafson, J. J. Hacker, B. R. Hall, E. D. Hall, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, J. Hanson, T. Hardwick, J. Harms, G. M. Harry, I. W. Harry, M. J. Hart, M. T. Hartman, C.-J. Haster, K. Haughian, J. Healy, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, A. W. Heptonstall, M. Heurs, S. Hild, D. Hoak, K. A. Hodge, D. Hofman, S. E. Hollitt, K. Holt, D. E. Holz, P. Hopkins, D. J. Hosken, J. Hough, E. A. Houston, E. J. Howell, Y. M. 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Krishnan, A. Królak, C. Krueger, G. Kuehn, P. Kumar, L. Kuo, A. Kutynia, B. D. Lackey, M. Landry, J. Lange, B. Lantz, P. D. Lasky, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, E. O. Lebigot, C. H. Lee, H. K. Lee, H. M. Lee, K. Lee, A. Lenon, M. Leonardi, J. R. Leong, N. Leroy, N. Letendre, Y. Levin, B. M. Levine, T. G. F. Li, A. Libson, T. B. Littenberg, N. A. Lockerbie, J. Logue, A. L. Lombardi, L. T. London, J. E. Lord, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, C. O. Lousto, G. Lovelace, H. Lück, A. P. Lundgren, J. Luo, R. Lynch, Y. Ma, T. MacDonald, B. Machenschalk, M. MacInnis, D. M. Macleod, F. Magaña-Sandoval, R. M. Magee, M. Mageswaran, E. Majorana, I. Maksimovic, V. Malvezzi, N. Man, I. Mandel, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, A. S. Markosyan, E. Maros, F. Martelli, L. Martellini, I. W. Martin, R. M. Martin, D. V. Martynov, J. N. Marx, K. Mason, A. Masserot, T. J. Massinger, M. Masso-Reid, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, G. Mazzolo, R. McCarthy, D. E. McClelland, S. McCormick, S. C. McGuire, G. McIntyre, J. McIver, D. J. McManus, S. T. McWilliams, D. Meacher, G. D. Meadors, J. Meidam, A. Melatos, G. Mendell, D. Mendoza-Gandara, R. A. Mercer, E. Merilh, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, P. M. Meyers, F. Mezzani, H. Miao, C. Michel, H. Middleton, E. E. Mikhailov, L. Milano, J. Miller, M. Millhouse, Y. Minenkov, J. Ming, S. Mirshekari, C. Mishra, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, A. Moggi, M. Mohan, S. R. P. Mohapatra, M. Montani, B. C. Moore, C. J. Moore, D. Moraru, G. Moreno, S. R. Morriss, K. Mossavi, B. Mours, C. M. Mow-Lowry, C. L. Mueller, G. Mueller, A. W. Muir, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, N. Mukund, A. Mullavey, J. Munch, D. J. Murphy, P. G. Murray, A. Mytidis, I. Nardecchia, L. Naticchioni, R. K. Nayak, V. Necula, K. Nedkova, G. Nelemans, M. Neri, A. Neunzert, G. 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Puncken, M. Punturo, P. Puppo, M. Pürrer, H. Qi, J. Qin, V. Quetschke, E. A. Quintero, R. Quitzow-James, F. J. Raab, D. S. Rabeling, H. Radkins, P. Raffai, S. Raja, M. Rakhmanov, P. Rapagnani, V. Raymond, M. Razzano, V. Re, J. Read, C. M. Reed, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, H. Rew, S. D. Reyes, F. Ricci, K. Riles, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, R. Romano, G. Romanov, J. H. Romie, D. Rosińska, C. Röver, S. Rowan, A. Rüdiger, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, L. Sadeghian, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, L. Sammut, E. J. Sanchez, V. Sandberg, B. Sandeen, J. R. Sanders, B. Sassolas, B. S. Sathyaprakash, P. R. Saulson, O. Sauter, R. L. Savage, A. Sawadsky, P. Schale, R. Schilling, J. Schmidt, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, D. Schuette, B. F. Schutz, J. Scott, S. M. Scott, D. Sellers, A. S. Sengupta, D. Sentenac, V. Sequino, A. Sergeev, G. Serna, Y. Setyawati, A. Sevigny, D. A. Shaddock, S. Shah, M. S. Shahriar, M. Shaltev, Z. Shao, B. Shapiro, P. Shawhan, A. Sheperd, D. H. Shoemaker, D. M. Shoemaker, K. Siellez, X. Siemens, D. Sigg, A. D. Silva, D. Simakov, A. Singer, L. P. Singer, A. Singh, R. Singh, A. Singhal, A. M. Sintes, B. J. J. Slagmolen, J. R. Smith, N. D. Smith, R. J. E. Smith, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, A. K. Srivastava, A. Staley, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, B. C. Stephens, S. P. Stevenson, R. Stone, K. A. Strain, N. Straniero, G. Stratta, N. A. Strauss, S. Strigin, R. Sturani, A. L. Stuver, T. Z. Summerscales, L. Sun, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, D. Talukder, D. B. Tanner, M. Tápai, S. P. Tarabrin, A. Taracchini, R. Taylor, T. Theeg, M. P. Thirugnanasambandam, E. G. Thomas, M. Thomas, P. Thomas, K. A. Thorne, K. S. Thorne, E. Thrane, S. Tiwari, V. Tiwari, K. V. Tokmakov, C. Tomlinson, M. Tonelli, C. V. Torres, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, D. Trifirò, M. C. Tringali, L. Trozzo, M. Tse, M. Turconi, D. Tuyenbayev, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, M. V. van der Sluys, J. V. van Heijningen, A. Vañó-Viñuales, A. A. van Veggel, M. Vardaro, S. Vass, M. Vasúth, R. Vaulin, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, D. Verkindt, F. Vetrano, A. Viceré, S. Vinciguerra, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, D. Voss, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, Y. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, T. Westphal, K. Wette, J. T. Whelan, D. J. White, B. F. Whiting, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Worden, J. L. Wright, G. Wu, J. Yablon, W. Yam, H. Yamamoto, C. C. Yancey, M. J. Yap, H. Yu, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, M. Zevin, F. Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, J. Zweizig, M. Boyle, B. Brügamin, M. Campanelli, M. Clark, D. Hamberger, L. E. Kidder, M. Kinsey, P. Laguna, S. Ossokine, M. A. Scheel, B. Szilagyi, S. Teukolsky, and Y. Zlochower
Published: 2016
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217. Observing gravitational-wave transient GW150914 with minimal assumptions

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. Bacon, M. K. M. Bader, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, B. Behnke, M. Bejger, A. S. Bell, C. J. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, L. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, C. Bogan, A. Bohe, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, B. A. Boom, R. Bork, V. Boschi, S. Bose, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. Callister, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, C. B. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, S. Chatterji, T. Chalermsongsak, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. Chassande-Mottin, H. Y. Chen, Y. Chen, C. Cheng, A. Chincarini, A. Chiummo, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, S. Chua, S. Chung, G. Ciani, F. Clara, J. A. Clark, M. Clark, F. Cleva, E. Coccia, P.-F. Cohadon, A. Colla, C. G. Collette, L. Cominsky, M. Constancio, A. Conte, L. Conti, D. Cook, T. R. Corbitt, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, K. Craig, J. D. E. Creighton, J. Cripe, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, S. L. Danilishin, S. D’Antonio, K. Danzmann, N. S. Darman, V. Dattilo, I. Dave, H. P. Daveloza, M. Davier, G. S. Davies, E. J. Daw, R. Day, D. DeBra, G. Debreczeni, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, T. Denker, T. Dent, H. Dereli, V. Dergachev, R. T. DeRosa, R. De Rosa, R. DeSalvo, S. Dhurandhar, M. C. Díaz, L. Di Fiore, M. Di Giovanni, A. Di Lieto, S. Di Pace, I. Di Palma, A. Di Virgilio, G. Dojcinoski, V. Dolique, F. Donovan, K. L. Dooley, S. Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, Z. Du, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. Eichholz, S. S. Eikenberry, W. Engels, R. C. Essick, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, H. Fair, S. Fairhurst, X. Fan, Q. Fang, S. Farinon, B. Farr, W. M. Farr, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, D. Fiorucci, R. P. Fisher, R. Flaminio, M. Fletcher, J.-D. Fournier, S. Franco, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, T. T. Fricke, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, A. Gatto, G. Gaur, N. Gehrels, G. Gemme, B. Gendre, E. Genin, A. Gennai, J. George, L. Gergely, V. Germain, Archisman Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, A. Glaefke, E. Goetz, R. Goetz, L. Gondan, G. González, J. M. Gonzalez Castro, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, R. Gouaty, C. Graef, P. B. Graff, M. Granata, A. Grant, S. Gras, C. Gray, G. Greco, A. C. Green, P. Groot, H. Grote, S. Grunewald, G. M. Guidi, X. Guo, A. Gupta, M. K. Gupta, K. E. Gushwa, E. K. Gustafson, R. Gustafson, R. Haas, J. J. Hacker, B. R. Hall, E. D. Hall, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, J. Hanson, T. Hardwick, J. Harms, G. M. Harry, I. W. Harry, M. J. Hart, M. T. Hartman, C.-J. Haster, K. Haughian, J. Healy, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, A. W. Heptonstall, M. Heurs, S. Hild, I. Hinder, D. Hoak, K. A. Hodge, D. Hofman, S. E. Hollitt, K. Holt, D. E. Holz, P. Hopkins, D. J. Hosken, J. Hough, E. A. Houston, E. J. Howell, Y. M. Hu, S. Huang, E. A. Huerta, D. Huet, B. Hughey, S. Husa, S. H. Huttner, T. Huynh-Dinh, A. Idrisy, N. Indik, D. R. Ingram, R. Inta, H. N. Isa, J.-M. Isac, M. Isi, G. Islas, T. Isogai, B. R. Iyer, K. Izumi, T. Jacqmin, H. Jang, K. Jani, P. Jaranowski, S. Jawahar, F. Jiménez-Forteza, W. W. Johnson, D. I. Jones, R. Jones, R. J. G. Jonker, L. Ju, Haris K, C. V. Kalaghatgi, V. Kalogera, S. Kandhasamy, G. Kang, J. B. Kanner, S. Karki, M. Kasprzack, E. Katsavounidis, W. Katzman, S. Kaufer, T. Kaur, K. Kawabe, F. Kawazoe, F. Kéfélian, M. S. Kehl, D. Keitel, D. B. Kelley, W. Kells, R. Kennedy, J. S. Key, A. Khalaidovski, F. Y. Khalili, I. Khan, S. Khan, Z. Khan, E. A. Khazanov, N. Kijbunchoo, C. Kim, J. Kim, K. Kim, Nam-Gyu Kim, Namjun Kim, Y.-M. Kim, E. J. King, P. J. King, M. Kinsey, D. L. Kinzel, J. S. Kissel, L. Kleybolte, S. Klimenko, S. M. Koehlenbeck, K. Kokeyama, S. Koley, V. Kondrashov, A. Kontos, M. Korobko, W. Z. Korth, I. Kowalska, D. B. Kozak, V. Kringel, A. Królak, C. Krueger, G. Kuehn, P. Kumar, L. Kuo, A. Kutynia, B. D. Lackey, P. Laguna, M. Landry, J. Lange, B. Lantz, P. D. Lasky, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, E. O. Lebigot, C. H. Lee, H. K. Lee, H. M. Lee, K. Lee, A. Lenon, M. Leonardi, J. R. Leong, N. Leroy, N. Letendre, Y. Levin, B. M. Levine, T. G. F. Li, A. Libson, T. B. Littenberg, N. A. Lockerbie, J. Logue, A. L. Lombardi, J. E. Lord, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, H. Lück, A. P. Lundgren, J. Luo, R. Lynch, Y. Ma, T. MacDonald, B. Machenschalk, M. MacInnis, D. M. Macleod, F. Magaña-Sandoval, R. M. Magee, M. Mageswaran, E. Majorana, I. Maksimovic, V. Malvezzi, N. Man, I. Mandel, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, A. S. Markosyan, E. Maros, F. Martelli, L. Martellini, I. W. Martin, R. M. Martin, D. V. Martynov, J. N. Marx, K. Mason, A. Masserot, T. J. Massinger, M. Masso-Reid, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, G. Mazzolo, R. McCarthy, D. E. McClelland, S. McCormick, S. C. McGuire, G. McIntyre, J. McIver, D. J. McManus, S. T. McWilliams, D. Meacher, G. D. Meadors, J. Meidam, A. Melatos, G. Mendell, D. Mendoza-Gandara, R. A. Mercer, E. Merilh, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, P. M. Meyers, F. Mezzani, H. Miao, C. Michel, H. Middleton, E. E. Mikhailov, L. Milano, J. Miller, M. Millhouse, Y. Minenkov, J. Ming, S. Mirshekari, C. Mishra, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, A. Moggi, M. Mohan, S. R. P. Mohapatra, M. Montani, B. C. Moore, C. J. Moore, D. Moraru, G. Moreno, S. R. Morriss, K. Mossavi, B. Mours, C. M. Mow-Lowry, C. L. Mueller, G. Mueller, A. W. Muir, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, N. Mukund, A. Mullavey, J. Munch, D. J. Murphy, P. G. Murray, A. Mytidis, I. Nardecchia, L. Naticchioni, R. K. Nayak, V. Necula, K. Nedkova, G. Nelemans, M. Neri, A. Neunzert, G. Newton, T. T. Nguyen, A. B. Nielsen, S. Nissanke, A. Nitz, F. Nocera, D. Nolting, M. E. Normandin, L. K. Nuttall, J. Oberling, E. Ochsner, J. O’Dell, E. Oelker, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. O’Shaughnessy, D. J. Ottaway, R. S. Ottens, H. Overmier, B. J. Owen, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, A. Pal-Singh, H. Pan, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, M. A. Papa, J. Page, H. R. Paris, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, B. Patricelli, Z. Patrick, B. L. Pearlstone, M. Pedraza, R. Pedurand, L. Pekowsky, A. Pele, S. Penn, A. Perreca, M. Phelps, O. Piccinni, M. Pichot, F. Piergiovanni, V. Pierro, G. Pillant, L. Pinard, I. M. Pinto, M. Pitkin, R. Poggiani, P. Popolizio, A. Post, J. Powell, J. Prasad, V. Predoi, S. S. Premachandra, T. Prestegard, L. R. Price, M. Prijatelj, M. Principe, S. Privitera, G. A. Prodi, L. Prokhorov, O. Puncken, M. Punturo, P. Puppo, M. Pürrer, H. Qi, J. Qin, V. Quetschke, E. A. Quintero, R. Quitzow-James, F. J. Raab, D. S. Rabeling, H. Radkins, P. Raffai, S. Raja, M. Rakhmanov, P. Rapagnani, V. Raymond, M. Razzano, V. Re, J. Read, C. M. Reed, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, H. Rew, S. D. Reyes, F. Ricci, K. Riles, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, R. Romano, G. Romanov, J. H. Romie, D. Rosińska, S. Rowan, A. Rüdiger, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, L. Sadeghian, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, L. Sammut, E. J. Sanchez, V. Sandberg, B. Sandeen, J. R. Sanders, B. Sassolas, B. S. Sathyaprakash, P. R. Saulson, O. Sauter, R. L. Savage, A. Sawadsky, P. Schale, R. Schilling, J. Schmidt, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, D. Schuette, B. F. Schutz, J. Scott, S. M. Scott, D. Sellers, A. S. Sengupta, D. Sentenac, V. Sequino, A. Sergeev, G. Serna, Y. Setyawati, A. Sevigny, D. A. Shaddock, S. Shah, M. S. Shahriar, M. Shaltev, Z. Shao, B. Shapiro, P. Shawhan, A. Sheperd, D. H. Shoemaker, D. M. Shoemaker, K. Siellez, X. Siemens, D. Sigg, A. D. Silva, D. Simakov, A. Singer, L. P. Singer, A. Singh, R. Singh, A. Singhal, A. M. Sintes, B. J. J. Slagmolen, J. R. Smith, N. D. Smith, R. J. E. Smith, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, A. K. Srivastava, A. Staley, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, B. C. Stephens, R. Stone, K. A. Strain, N. Straniero, G. Stratta, N. A. Strauss, S. Strigin, R. Sturani, A. L. Stuver, T. Z. Summerscales, L. Sun, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, D. Talukder, D. B. Tanner, M. Tápai, S. P. Tarabrin, A. Taracchini, R. Taylor, T. Theeg, M. P. Thirugnanasambandam, E. G. Thomas, M. Thomas, P. Thomas, K. A. Thorne, K. S. Thorne, E. Thrane, S. Tiwari, V. Tiwari, K. V. Tokmakov, C. Tomlinson, M. Tonelli, C. V. Torres, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, D. Trifirò, M. C. Tringali, L. Trozzo, M. Tse, M. Turconi, D. Tuyenbayev, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. van Heijningen, A. A. van Veggel, M. Vardaro, S. Vass, M. Vasúth, R. Vaulin, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, D. Verkindt, F. Vetrano, A. Viceré, S. Vinciguerra, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, D. Voss, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, Y. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, T. Westphal, K. Wette, J. T. Whelan, D. J. White, B. F. Whiting, D. Williams, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Worden, J. L. Wright, G. Wu, J. Yablon, W. Yam, H. Yamamoto, C. C. Yancey, M. J. Yap, H. Yu, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, M. Zevin, F. Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, and J. Zweizig
Published: 2016
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218. GW150914: First results from the search for binary black hole coalescence with Advanced LIGO

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. Bacon, M. K. M. Bader, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, B. Behnke, M. Bejger, A. S. Bell, C. J. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, C. Bogan, A. Bohe, K. Bohémier, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, B. A. Boom, R. Bork, V. Boschi, S. Bose, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. Callister, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, C. B. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, T. Chalermsongsak, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. Chassande-Mottin, H. Y. Chen, Y. Chen, C. Cheng, A. Chincarini, A. Chiummo, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, S. Chua, S. Chung, G. Ciani, F. Clara, J. A. Clark, J. H. Clayton, F. Cleva, E. Coccia, P.-F. Cohadon, T. Cokelaer, A. Colla, C. G. Collette, L. Cominsky, M. Constancio, A. Conte, L. Conti, D. Cook, T. R. Corbitt, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, K. Craig, J. D. E. Creighton, T. D. Creighton, J. Cripe, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, S. L. Danilishin, S. D’Antonio, K. Danzmann, N. S. Darman, V. Dattilo, I. Dave, H. P. Daveloza, M. Davier, G. S. Davies, E. J. Daw, R. Day, S. De, D. DeBra, G. Debreczeni, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, T. Denker, T. Dent, H. Dereli, V. Dergachev, R. T. DeRosa, R. De Rosa, R. DeSalvo, S. Dhurandhar, M. C. Díaz, A. Dietz, L. Di Fiore, M. Di Giovanni, A. Di Lieto, S. Di Pace, I. Di Palma, A. Di Virgilio, G. Dojcinoski, V. Dolique, F. Donovan, K. L. Dooley, S. Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, Z. Du, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. Eichholz, S. S. Eikenberry, W. Engels, R. C. Essick, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, H. Fair, S. Fairhurst, X. Fan, Q. Fang, S. Farinon, B. Farr, W. M. Farr, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, D. Fiorucci, R. P. Fisher, R. Flaminio, M. Fletcher, N. Fotopoulos, J.-D. Fournier, S. Franco, S. Frasca, F. Frasconi, M. Frei, Z. Frei, A. Freise, R. Frey, V. Frey, T. T. Fricke, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, A. Gatto, G. Gaur, N. Gehrels, G. Gemme, B. Gendre, E. Genin, A. Gennai, J. George, L. Gergely, V. Germain, A. Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, A. Glaefke, E. Goetz, R. Goetz, L. M. Goggin, L. Gondan, G. González, J. M. Gonzalez Castro, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, R. Gouaty, C. Graef, P. B. Graff, M. Granata, A. Grant, S. Gras, C. Gray, G. Greco, A. C. Green, P. Groot, H. Grote, S. Grunewald, G. M. Guidi, X. Guo, A. Gupta, M. K. Gupta, K. E. Gushwa, E. K. Gustafson, R. Gustafson, J. J. Hacker, B. R. Hall, E. D. Hall, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, J. Hanson, T. Hardwick, J. Harms, G. M. Harry, I. W. Harry, M. J. Hart, M. T. Hartman, C.-J. Haster, K. Haughian, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, A. W. Heptonstall, M. Heurs, S. Hild, D. Hoak, K. A. Hodge, D. Hofman, S. E. Hollitt, K. Holt, D. E. Holz, P. Hopkins, D. J. Hosken, J. Hough, E. A. Houston, E. J. Howell, Y. M. Hu, S. Huang, E. A. Huerta, D. Huet, B. Hughey, S. Husa, S. H. Huttner, T. Huynh-Dinh, A. Idrisy, N. Indik, D. R. Ingram, R. Inta, H. N. Isa, J.-M. Isac, M. Isi, G. Islas, T. Isogai, B. R. Iyer, K. Izumi, T. Jacqmin, H. Jang, K. Jani, P. Jaranowski, S. Jawahar, F. Jiménez-Forteza, W. W. Johnson, D. I. Jones, G. Jones, R. Jones, R. J. G. Jonker, L. Ju, Haris K, C. V. Kalaghatgi, V. Kalogera, S. Kandhasamy, G. Kang, J. B. Kanner, S. Karki, M. Kasprzack, E. Katsavounidis, W. Katzman, S. Kaufer, T. Kaur, K. Kawabe, F. Kawazoe, F. Kéfélian, M. S. Kehl, D. Keitel, D. B. Kelley, W. Kells, D. G. Keppel, R. Kennedy, J. S. Key, A. Khalaidovski, F. Y. Khalili, I. Khan, S. Khan, Z. Khan, E. A. Khazanov, N. Kijbunchoo, C. Kim, J. Kim, K. Kim, Nam-Gyu Kim, Namjun Kim, Y.-M. Kim, E. J. King, P. J. King, D. L. Kinzel, J. S. Kissel, L. Kleybolte, S. Klimenko, S. M. Koehlenbeck, K. Kokeyama, S. Koley, V. Kondrashov, A. Kontos, M. Korobko, W. Z. Korth, I. Kowalska, D. B. Kozak, V. Kringel, B. Krishnan, A. Królak, C. Krueger, G. Kuehn, P. Kumar, L. Kuo, A. Kutynia, B. D. Lackey, M. Landry, J. Lange, B. Lantz, P. D. Lasky, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, E. O. Lebigot, C. H. Lee, H. K. Lee, H. M. Lee, K. Lee, A. Lenon, M. Leonardi, J. R. Leong, N. Leroy, N. Letendre, Y. Levin, B. M. Levine, T. G. F. Li, A. Libson, T. B. Littenberg, N. A. Lockerbie, J. Logue, A. L. Lombardi, J. E. Lord, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, H. Lück, A. P. Lundgren, J. Luo, R. Lynch, Y. Ma, T. MacDonald, B. Machenschalk, M. MacInnis, D. M. Macleod, F. Magaña-Sandoval, R. M. Magee, M. Mageswaran, E. Majorana, I. Maksimovic, V. Malvezzi, N. Man, I. Mandel, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, A. S. Markosyan, E. Maros, F. Martelli, L. Martellini, I. W. Martin, R. M. Martin, D. V. Martynov, J. N. Marx, K. Mason, A. Masserot, T. J. Massinger, M. Masso-Reid, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, G. Mazzolo, R. McCarthy, D. E. McClelland, S. McCormick, S. C. McGuire, G. McIntyre, J. McIver, D. J. A. McKechan, D. J. McManus, S. T. McWilliams, D. Meacher, G. D. Meadors, J. Meidam, A. Melatos, G. Mendell, D. Mendoza-Gandara, R. A. Mercer, E. Merilh, M. Merzougui, S. Meshkov, E. Messaritaki, C. Messenger, C. Messick, P. M. Meyers, F. Mezzani, H. Miao, C. Michel, H. Middleton, E. E. Mikhailov, L. Milano, J. Miller, M. Millhouse, Y. Minenkov, J. Ming, S. Mirshekari, C. Mishra, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, A. Moggi, M. Mohan, S. R. P. Mohapatra, M. Montani, B. C. Moore, C. J. Moore, D. Moraru, G. Moreno, S. R. Morriss, K. Mossavi, B. Mours, C. M. Mow-Lowry, C. L. Mueller, G. Mueller, A. W. Muir, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, N. Mukund, A. Mullavey, J. Munch, D. J. Murphy, P. G. Murray, A. Mytidis, I. Nardecchia, L. Naticchioni, R. K. Nayak, V. Necula, K. Nedkova, G. Nelemans, M. Neri, A. Neunzert, G. Newton, T. T. Nguyen, A. B. Nielsen, S. Nissanke, A. Nitz, F. Nocera, D. Nolting, M. E. Normandin, L. K. Nuttall, J. Oberling, E. Ochsner, J. O’Dell, E. Oelker, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. O’Shaughnessy, D. J. Ottaway, R. S. Ottens, H. Overmier, B. J. Owen, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, A. Pal-Singh, H. Pan, Y. Pan, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, M. A. Papa, H. R. Paris, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, B. Patricelli, Z. Patrick, B. L. Pearlstone, M. Pedraza, R. Pedurand, L. Pekowsky, A. Pele, S. Penn, A. Perreca, M. Phelps, O. Piccinni, M. Pichot, F. Piergiovanni, V. Pierro, G. Pillant, L. Pinard, I. M. Pinto, M. Pitkin, R. Poggiani, P. Popolizio, A. Post, J. Powell, J. Prasad, V. Predoi, S. S. Premachandra, T. Prestegard, L. R. Price, M. Prijatelj, M. Principe, S. Privitera, G. A. Prodi, L. Prokhorov, O. Puncken, M. Punturo, P. Puppo, M. Pürrer, H. Qi, J. Qin, V. Quetschke, E. A. Quintero, R. Quitzow-James, F. J. Raab, D. S. Rabeling, H. Radkins, P. Raffai, S. Raja, M. Rakhmanov, P. Rapagnani, V. Raymond, M. Razzano, V. Re, J. Read, C. M. Reed, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, H. Rew, S. D. Reyes, F. Ricci, K. Riles, N. A. Robertson, R. Robie, F. Robinet, C. Robinson, A. Rocchi, A. C. Rodriguez, L. Rolland, J. G. Rollins, V. J. Roma, R. Romano, G. Romanov, J. H. Romie, D. Rosińska, S. Rowan, A. Rüdiger, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, L. Sadeghian, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, L. Sammut, E. J. Sanchez, V. Sandberg, B. Sandeen, J. R. Sanders, L. Santamaría, B. Sassolas, B. S. Sathyaprakash, P. R. Saulson, O. Sauter, R. L. Savage, A. Sawadsky, P. Schale, R. Schilling, J. Schmidt, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, D. Schuette, B. F. Schutz, J. Scott, S. M. Scott, D. Sellers, A. S. Sengupta, D. Sentenac, V. Sequino, A. Sergeev, G. Serna, Y. Setyawati, A. Sevigny, D. A. Shaddock, S. Shah, M. S. Shahriar, M. Shaltev, Z. Shao, B. Shapiro, P. Shawhan, A. Sheperd, D. H. Shoemaker, D. M. Shoemaker, K. Siellez, X. Siemens, D. Sigg, A. D. Silva, D. Simakov, A. Singer, L. P. Singer, A. Singh, R. Singh, A. Singhal, A. M. Sintes, B. J. J. Slagmolen, J. R. Smith, N. D. Smith, R. J. E. Smith, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, A. K. Srivastava, A. Staley, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, B. C. Stephens, R. Stone, K. A. Strain, N. Straniero, G. Stratta, N. A. Strauss, S. Strigin, R. Sturani, A. L. Stuver, T. Z. Summerscales, L. Sun, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, D. Talukder, D. B. Tanner, M. Tápai, S. P. Tarabrin, A. Taracchini, R. Taylor, T. Theeg, M. P. Thirugnanasambandam, E. G. Thomas, M. Thomas, P. Thomas, K. A. Thorne, K. S. Thorne, E. Thrane, S. Tiwari, V. Tiwari, K. V. Tokmakov, C. Tomlinson, M. Tonelli, C. V. Torres, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, D. Trifirò, M. C. Tringali, L. Trozzo, M. Tse, M. Turconi, D. Tuyenbayev, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. van Heijningen, A. A. van Veggel, M. Vardaro, S. Vass, M. Vasúth, R. Vaulin, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, D. Verkindt, F. Vetrano, A. Viceré, S. Vinciguerra, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, D. Voss, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, Y. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, M. West, T. Westphal, K. Wette, J. T. Whelan, D. J. White, B. F. Whiting, K. Wiesner, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, A. G. Wiseman, H. Wittel, G. Woan, J. Worden, J. L. Wright, G. Wu, J. Yablon, W. Yam, H. Yamamoto, C. C. Yancey, M. J. Yap, H. Yu, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, M. Zevin, F. Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, and J. Zweizig
Published: 2016
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219. First low frequency all-sky search for continuous gravitational wave signals

Author: J. Aasi, B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, A. Ain, P. Ajith, B. Allen, A. Allocca, D. V. Amariutei, M. Andersen, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, G. Ashton, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, J. Bartlett, M. A. Barton, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, B. Behnke, M. Bejger, C. Belczynski, A. S. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, R. Bork, M. Born, V. Boschi, Sukanta Bose, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, V. Branco, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, J. Calderón Bustillo, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, C. Celerier, G. Cella, C. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, T. Chalermsongsak, S. J. Chamberlin, S. Chao, P. Charlton, E. Chassande-Mottin, X. Chen, Y. Chen, C. Cheng, A. Chincarini, A. Chiummo, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, S. Chua, S. Chung, G. Ciani, F. Clara, J. A. Clark, F. Cleva, E. Coccia, P.-F. Cohadon, A. Colla, C. G. Collette, M. Colombini, M. Constancio, A. Conte, L. Conti, D. Cook, T. R. Corbitt, N. Cornish, A. Corsi, C. A. Costa, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, K. Craig, J. D. E. Creighton, J. Cripe, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, M. D. Damjanic, S. L. Danilishin, S. D’Antonio, K. Danzmann, N. S. Darman, V. Dattilo, I. Dave, H. P. Daveloza, M. Davier, G. S. Davies, E. J. Daw, R. Day, D. DeBra, G. Debreczeni, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, T. Denker, T. Dent, H. Dereli, V. Dergachev, R. De Rosa, R. T. DeRosa, R. DeSalvo, S. Dhurandhar, M. C. Díaz, L. Di Fiore, M. Di Giovanni, A. Di Lieto, I. Di Palma, A. Di Virgilio, G. Dojcinoski, V. Dolique, E. Dominguez, F. Donovan, K. L. Dooley, S. Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, Z. Du, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, M. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. M. Eichholz, S. S. Eikenberry, R. C. Essick, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, S. Fairhurst, Q. Fang, S. Farinon, B. Farr, W. M. Farr, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, D. Feldbaum, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, R. P. Fisher, R. Flaminio, J.-D. Fournier, S. Franco, S. Frasca, F. Frasconi, M. Frede, Z. Frei, A. Freise, R. Frey, T. T. Fricke, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, A. Gatto, N. Gehrels, G. Gemme, B. Gendre, E. Genin, A. Gennai, L. Á. Gergely, V. Germain, A. Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, J. R. Gleason, E. Goetz, R. Goetz, L. Gondan, G. González, J. Gonzalez, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. 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Jaranowski, S. Jawahar, Y. Ji, F. Jiménez-Forteza, W. W. Johnson, D. I. Jones, R. Jones, R. J. G. Jonker, L. Ju, K. Haris, V. Kalogera, S. Kandhasamy, G. Kang, J. B. Kanner, S. Karki, J. L. Karlen, M. Kasprzack, E. Katsavounidis, W. Katzman, S. Kaufer, T. Kaur, K. Kawabe, F. Kawazoe, F. Kéfélian, M. S. Kehl, D. Keitel, D. B. Kelley, W. Kells, J. Kerrigan, J. S. Key, F. Y. Khalili, Z. Khan, E. A. Khazanov, N. Kijbunchoo, C. Kim, K. Kim, N. G. Kim, N. Kim, Y.-M. Kim, E. J. King, P. J. King, D. L. Kinzel, J. S. Kissel, S. Klimenko, J. T. Kline, S. M. Koehlenbeck, K. Kokeyama, S. Koley, V. Kondrashov, M. Korobko, W. Z. Korth, I. Kowalska, D. B. Kozak, V. Kringel, B. Krishnan, A. Królak, C. Krueger, G. Kuehn, A. Kumar, P. Kumar, L. Kuo, A. Kutynia, B. D. Lackey, M. Landry, B. Lantz, P. D. Lasky, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, E. O. Lebigot, C. H. Lee, H. K. Lee, H. M. Lee, J. Lee, J. P. Lee, M. Leonardi, J. R. Leong, N. Leroy, N. Letendre, Y. Levin, B. M. Levine, J. B. 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Vocca, C. Vorvick, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, M. Wade, L. E. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, T. Westphal, K. Wette, J. T. Whelan, S. E. Whitcomb, D. J. White, B. F. Whiting, K. J. Williams, L. Williams, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Worden, J. Yablon, I. Yakushin, W. Yam, H. Yamamoto, C. C. Yancey, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, Fan Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, and J. Zweizig
Published: 2016
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220. Search of the Orion spur for continuous gravitational waves using a loosely coherent algorithm on data from LIGO interferometers

Author: J. Aasi, B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, A. Ain, P. Ajith, B. Allen, A. Allocca, D. V. Amariutei, M. Andersen, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, G. Ashton, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, J. Bartlett, M. A. Barton, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, B. Behnke, M. Bejger, C. Belczynski, A. S. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, R. Bork, M. Born, V. Boschi, Sukanta Bose, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, V. Branco, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, J. Calderón Bustillo, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, C. Celerier, G. Cella, C. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, T. Chalermsongsak, S. J. Chamberlin, S. Chao, P. Charlton, E. Chassande-Mottin, X. Chen, Y. Chen, C. Cheng, A. Chincarini, A. Chiummo, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, S. Chua, S. Chung, G. Ciani, F. Clara, J. A. Clark, F. Cleva, E. Coccia, P.-F. Cohadon, A. Colla, C. G. Collette, M. Colombini, M. Constancio, A. Conte, L. Conti, D. Cook, T. R. Corbitt, N. Cornish, A. Corsi, C. A. Costa, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, K. Craig, J. D. E. Creighton, T. Creighton, J. Cripe, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, M. D. Damjanic, S. L. Danilishin, S. D’Antonio, K. Danzmann, N. S. Darman, V. Dattilo, I. Dave, H. P. Daveloza, M. Davier, G. S. Davies, E. J. Daw, R. Day, D. DeBra, G. Debreczeni, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, T. Denker, T. Dent, H. Dereli, V. Dergachev, R. De Rosa, R. T. DeRosa, R. DeSalvo, S. Dhurandhar, M. C. Díaz, L. Di Fiore, M. Di Giovanni, A. Di Lieto, I. Di Palma, A. Di Virgilio, G. Dojcinoski, V. Dolique, E. Dominguez, F. Donovan, K. L. Dooley, S. Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, Z. Du, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, M. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. M. Eichholz, S. S. Eikenberry, R. C. Essick, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, S. Fairhurst, Q. Fang, S. Farinon, B. Farr, W. M. Farr, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, D. Feldbaum, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, R. P. Fisher, R. Flaminio, J.-D. Fournier, S. Franco, S. Frasca, F. Frasconi, M. Frede, Z. Frei, A. Freise, R. Frey, T. T. Fricke, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, A. Gatto, N. Gehrels, G. Gemme, B. Gendre, E. Genin, A. Gennai, L. Á. Gergely, V. Germain, A. Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, J. R. Gleason, E. Goetz, R. Goetz, L. Gondan, G. González, J. Gonzalez, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, S. Goßler, R. Gouaty, C. Graef, P. B. Graff, M. Granata, A. Grant, S. Gras, C. Gray, G. Greco, P. Groot, H. Grote, K. Grover, S. Grunewald, G. M. Guidi, C. J. Guido, X. Guo, A. Gupta, M. K. Gupta, K. E. Gushwa, E. K. Gustafson, R. Gustafson, J. J. Hacker, B. R. Hall, E. D. Hall, D. Hammer, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, J. Hanson, T. Hardwick, J. Harms, G. M. Harry, I. W. Harry, M. J. Hart, M. T. Hartman, C.-J. Haster, K. Haughian, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, A. W. Heptonstall, M. Heurs, S. Hild, D. Hoak, K. A. Hodge, J. Hoelscher-Obermaier, D. Hofman, S. E. Hollitt, K. Holt, P. Hopkins, D. J. Hosken, J. Hough, E. A. Houston, E. J. Howell, Y. M. Hu, S. Huang, E. A. Huerta, D. Huet, B. Hughey, S. Husa, S. H. Huttner, M. Huynh, T. Huynh-Dinh, A. Idrisy, N. Indik, D. R. Ingram, R. Inta, G. Islas, J. C. Isler, T. Isogai, B. R. Iyer, K. Izumi, M. B. Jacobson, H. Jang, P. Jaranowski, S. Jawahar, Y. Ji, F. Jiménez-Forteza, W. W. Johnson, D. I. Jones, R. Jones, R. J. G. Jonker, L. Ju, K. Haris, V. Kalogera, S. Kandhasamy, G. Kang, J. B. Kanner, S. Karki, J. L. Karlen, M. Kasprzack, E. Katsavounidis, W. Katzman, S. Kaufer, T. Kaur, K. Kawabe, F. Kawazoe, F. Kéfélian, M. S. Kehl, D. Keitel, N. Kelecsenyi, D. B. Kelley, W. Kells, J. Kerrigan, J. S. Key, F. Y. Khalili, Z. Khan, E. A. Khazanov, N. Kijbunchoo, C. Kim, K. Kim, N. G. Kim, N. Kim, Y.-M. Kim, E. J. King, P. J. King, D. L. Kinzel, J. S. Kissel, S. Klimenko, J. T. Kline, S. M. Koehlenbeck, K. Kokeyama, S. Koley, V. Kondrashov, M. Korobko, W. Z. Korth, I. Kowalska, D. B. Kozak, V. Kringel, B. Krishnan, A. Królak, C. Krueger, G. Kuehn, A. Kumar, P. Kumar, L. Kuo, A. Kutynia, B. D. Lackey, M. Landry, B. Lantz, P. D. Lasky, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, E. O. Lebigot, C. H. Lee, H. K. Lee, H. M. Lee, J. Lee, J. P. Lee, M. Leonardi, J. R. Leong, N. Leroy, N. Letendre, Y. Levin, B. M. Levine, J. B. Lewis, T. G. F. Li, A. Libson, A. C. Lin, T. B. Littenberg, N. A. Lockerbie, V. Lockett, D. Lodhia, J. Logue, A. L. Lombardi, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, M. J. Lubinski, H. Lück, A. P. Lundgren, J. Luo, R. Lynch, Y. Ma, J. Macarthur, E. P. Macdonald, T. MacDonald, B. Machenschalk, M. MacInnis, D. M. Macleod, D. X. Madden-Fong, F. Magaña-Sandoval, R. M. Magee, M. Mageswaran, E. Majorana, I. Maksimovic, V. Malvezzi, N. Man, I. Mandel, V. Mandic, V. Mangano, N. M. Mangini, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, A. S. Markosyan, E. Maros, F. Martelli, L. Martellini, I. W. Martin, R. M. Martin, D. V. Martynov, J. N. Marx, K. Mason, A. Masserot, T. J. Massinger, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, G. Mazzolo, R. McCarthy, D. E. McClelland, S. McCormick, S. C. McGuire, G. McIntyre, J. McIver, S. T. McWilliams, D. Meacher, G. D. Meadors, M. Mehmet, J. Meidam, M. Meinders, A. 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Vorvick, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, M. Wade, L. E. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, T. Westphal, K. Wette, J. T. Whelan, D. J. White, B. F. Whiting, K. J. Williams, L. Williams, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Worden, J. Yablon, I. Yakushin, W. Yam, H. Yamamoto, C. C. Yancey, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, Fan Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, and J. Zweizig
Published: 2016
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221. All-sky search for long-duration gravitational wave transients with initial LIGO

Author: B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, A. Ain, P. Ajith, B. Allen, A. Allocca, D. V. Amariutei, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun, G. Ashton, M. Ast, S. M. Aston, P. Astone, P. Aufmuth, C. Aulbert, S. Babak, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, C. Baune, V. Bavigadda, M. Bazzan, B. Behnke, M. Bejger, C. Belczynski, A. S. Bell, C. J. Bell, B. K. Berger, J. Bergman, G. Bergmann, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, S. Bhagwat, R. Bhandare, I. A. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, M. Bitossi, C. Biwer, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. Blair, R. M. Blair, S. Bloemen, O. Bock, T. P. Bodiya, M. Boer, G. Bogaert, C. Bogan, A. Bohe, P. Bojtos, C. Bond, F. Bondu, R. Bonnand, R. Bork, V. Boschi, S. Bose, A. Bozzi, C. Bradaschia, P. R. Brady, V. B. Braginsky, M. Branchesi, J. E. Brau, T. Briant, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. A. Brown, D. Brown, D. D. Brown, N. M. Brown, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. Callister, E. Calloni, J. B. Camp, K. C. Cannon, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, C. Cepeda, L. Cerboni Baiardi, G. Cerretani, E. Cesarini, R. Chakraborty, T. Chalermsongsak, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. Chassande-Mottin, H. Y. Chen, Y. Chen, C. Cheng, A. 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Doravari, R. Douglas, T. P. Downes, M. Drago, R. W. P. Drever, J. C. Driggers, Z. Du, M. Ducrot, S. E. Dwyer, T. B. Edo, M. C. Edwards, A. Effler, H.-B. Eggenstein, P. Ehrens, J. M. Eichholz, S. S. Eikenberry, W. Engels, R. C. Essick, T. Etzel, M. Evans, T. M. Evans, R. Everett, M. Factourovich, V. Fafone, H. Fair, S. Fairhurst, X. Fan, Q. Fang, S. Farinon, B. Farr, W. M. Farr, M. Favata, M. Fays, H. Fehrmann, M. M. Fejer, I. Ferrante, E. C. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, R. P. Fisher, R. Flaminio, M. Fletcher, J.-D. Fournier, S. Franco, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, T. T. Fricke, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. G. Gabbard, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, F. Garufi, A. Gatto, G. Gaur, N. Gehrels, G. Gemme, B. Gendre, E. Genin, A. Gennai, J. George, L. Gergely, V. Germain, A. Ghosh, S. Ghosh, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, A. Glaefke, E. Goetz, R. Goetz, L. Gondan, G. González, J. M. Gonzalez Castro, A. Gopakumar, N. A. Gordon, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, R. Gouaty, C. Graef, P. B. Graff, M. Granata, A. Grant, S. Gras, C. Gray, G. Greco, A. C. Green, P. Groot, H. Grote, S. Grunewald, G. M. Guidi, X. Guo, A. Gupta, M. K. Gupta, K. E. Gushwa, E. K. Gustafson, R. Gustafson, J. J. Hacker, B. R. Hall, E. D. Hall, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, J. Hanson, T. Hardwick, J. Harms, G. M. Harry, I. W. Harry, M. J. Hart, M. T. Hartman, C.-J. Haster, K. Haughian, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, A. W. Heptonstall, M. Heurs, S. Hild, D. Hoak, K. A. Hodge, D. Hofman, S. E. Hollitt, K. Holt, D. E. Holz, P. Hopkins, D. J. Hosken, J. Hough, E. A. Houston, E. J. Howell, Y. M. Hu, S. Huang, E. A. Huerta, D. Huet, B. Hughey, S. Husa, S. H. Huttner, T. Huynh-Dinh, A. Idrisy, N. Indik, D. R. Ingram, R. Inta, H. N. Isa, J.-M. Isac, M. Isi, G. Islas, T. Isogai, B. R. 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R. Leong, N. Leroy, N. Letendre, Y. Levin, B. M. Levine, T. G. F. Li, A. Libson, T. B. Littenberg, N. A. Lockerbie, J. Logue, A. L. Lombardi, J. E. Lord, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, H. Lück, A. P. Lundgren, J. Luo, R. Lynch, Y. Ma, T. MacDonald, B. Machenschalk, M. MacInnis, D. M. Macleod, F. Magaña-Sandoval, R. M. Magee, M. Mageswaran, E. Majorana, I. Maksimovic, V. Malvezzi, N. Man, I. Mandel, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, A. S. Markosyan, E. Maros, F. Martelli, L. Martellini, I. W. Martin, R. M. Martin, D. V. Martynov, J. N. Marx, K. Mason, A. Masserot, T. J. Massinger, M. Masso-Reid, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, G. Mazzolo, R. McCarthy, D. E. McClelland, S. McCormick, S. C. McGuire, G. McIntyre, J. McIver, S. T. McWilliams, D. Meacher, G. D. Meadors, J. Meidam, A. Melatos, G. Mendell, D. Mendoza-Gandara, R. A. Mercer, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, P. M. Meyers, F. Mezzani, H. Miao, C. Michel, H. Middleton, E. E. Mikhailov, L. Milano, J. Miller, M. Millhouse, Y. Minenkov, J. Ming, S. Mirshekari, C. Mishra, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, A. Moggi, S. R. P. Mohapatra, M. Montani, B. C. Moore, C. J. Moore, D. Moraru, G. Moreno, S. R. Morriss, K. Mossavi, B. Mours, C. M. Mow-Lowry, C. L. Mueller, G. Mueller, A. W. Muir, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, A. Mullavey, J. Munch, D. J. Murphy, P. G. Murray, A. Mytidis, I. Nardecchia, L. Naticchioni, R. K. Nayak, V. Necula, K. Nedkova, G. Nelemans, M. Neri, A. Neunzert, G. Newton, T. T. Nguyen, A. B. Nielsen, S. Nissanke, A. Nitz, F. Nocera, D. Nolting, M. E. N. Normandin, L. K. Nuttall, J. Oberling, E. Ochsner, J. O’Dell, E. Oelker, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. O’Shaughnessy, C. D. Ott, D. J. Ottaway, R. S. Ottens, H. Overmier, B. J. Owen, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, A. Pal-Singh, H. Pan, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, M. A. Papa, H. R. Paris, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, Z. Patrick, B. L. Pearlstone, M. Pedraza, R. Pedurand, L. Pekowsky, A. Pele, S. Penn, R. Pereira, A. Perreca, M. Phelps, O. Piccinni, M. Pichot, F. Piergiovanni, V. Pierro, G. Pillant, L. Pinard, I. M. Pinto, M. Pitkin, R. Poggiani, A. Post, J. Powell, J. Prasad, V. Predoi, S. S. Premachandra, T. Prestegard, L. R. Price, M. Prijatelj, M. Principe, S. Privitera, G. A. Prodi, L. Prokhorov, M. Punturo, P. Puppo, M. Pürrer, H. Qi, J. Qin, V. Quetschke, E. A. Quintero, R. Quitzow-James, F. J. Raab, D. S. Rabeling, H. Radkins, P. Raffai, S. Raja, M. Rakhmanov, P. Rapagnani, V. Raymond, M. Razzano, V. Re, J. Read, C. M. Reed, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, H. Rew, F. Ricci, K. Riles, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, J. D. Romano, R. Romano, G. Romanov, J. H. Romie, D. Rosińska, S. Rowan, A. Rüdiger, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, L. Sadeghian, M. Saleem, F. Salemi, A. Samajdar, L. Sammut, E. J. Sanchez, V. Sandberg, B. Sandeen, J. R. Sanders, B. Sassolas, P. R. Saulson, O. Sauter, R. Savage, A. Sawadsky, P. Schale, R. Schilling, J. Schmidt, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, D. Schuette, B. F. Schutz, J. Scott, S. M. Scott, D. Sellers, D. Sentenac, V. Sequino, A. Sergeev, G. Serna, Y. Setyawati, A. Sevigny, D. A. Shaddock, S. Shah, M. S. Shahriar, M. Shaltev, Z. Shao, B. Shapiro, P. Shawhan, A. Sheperd, D. H. Shoemaker, D. M. Shoemaker, K. Siellez, X. Siemens, D. Sigg, A. D. Silva, D. Simakov, A. Singer, L. P. Singer, A. Singh, R. Singh, A. M. Sintes, B. J. J. Slagmolen, J. R. Smith, N. D. Smith, R. J. E. Smith, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, A. K. Srivastava, A. Staley, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, B. C. Stephens, R. Stone, K. A. Strain, N. Straniero, G. Stratta, N. A. Strauss, S. Strigin, R. Sturani, A. L. Stuver, T. Z. Summerscales, L. Sun, P. J. Sutton, B. L. Swinkels, M. J. Szczepanczyk, M. Tacca, D. Talukder, D. B. Tanner, M. Tápai, S. P. Tarabrin, A. Taracchini, R. Taylor, T. Theeg, M. P. Thirugnanasambandam, E. G. Thomas, M. Thomas, P. Thomas, K. A. Thorne, K. S. Thorne, E. Thrane, S. Tiwari, V. Tiwari, C. Tomlinson, M. Tonelli, C. V. Torres, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, D. Trifirò, M. C. Tringali, L. Trozzo, M. Tse, M. Turconi, D. Tuyenbayev, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. van den Broeck, L. van der Schaaf, M. V. van der Sluys, J. V. van Heijningen, A. A. van Veggel, M. Vardaro, S. Vass, M. Vasúth, R. Vaulin, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, D. Verkindt, F. Vetrano, A. Viceré, S. Vinciguerra, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, W. D. Vousden, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, M. Wang, X. Wang, Y. Wang, R. L. Ward, J. Warner, M. Was, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, T. Welborn, L. Wen, P. Weßels, T. Westphal, K. Wette, J. T. Whelan, D. J. White, B. F. Whiting, R. D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Worden, J. L. Wright, G. Wu, J. Yablon, W. Yam, H. Yamamoto, C. C. Yancey, H. Yu, M. Yvert, A. Zadrożny, L. Zangrando, M. Zanolin, J.-P. Zendri, M. Zevin, F. Zhang, L. Zhang, M. Zhang, Y. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, M. E. Zucker, S. E. Zuraw, and J. Zweizig
Published: 2016
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222. A Standardized Investigational Ki-67 Immunohistochemistry Assay Used to Assess High-Risk Early Breast Cancer Patients in the monarchE Phase 3 Clinical Study Identifies a Population With Greater Risk of Disease Recurrence When Treated With Endocrine Therapy Alone

Author: Monika D. Polewski, Gitte B. Nielsen, Ying Gu, Aaron T. Weaver, Gavin Gegg, Siena Tabuena-Frolli, Mariana Cajaiba, Debra Hanks, Michael Method, Michael F. Press, Claudia Gottstein, and Aaron M. Gruver
Subjects: Medical Laboratory Technology, Histology, Ki-67 Antigen, Receptor, ErbB-2, Biomarkers, Tumor, Humans, Reproducibility of Results, Breast Neoplasms, Female, Neoplasm Recurrence, Local, Immunohistochemistry, Pathology and Forensic Medicine
Abstract: The objectives were to develop a standardized Ki-67 immunohistochemistry (IHC) method for precise, robust, and reproducible assessment of patients with early breast cancer, and utilize this assay to evaluate patients participating in the monarchE study (NCT03155997). The Ki-67 assay was developed and validated for sensitivity, specificity, repeatability, precision, and robustness using a predefined ≥20% cutoff. Reproducibility studies (intersite and intrasite, interobserver and intraobserver) were conducted at 3 external laboratories using detailed scoring instructions designed for monarchE. Using the assay, patient tumors were classified as displaying high (≥20%) or low (20%) Ki-67 expression; Kaplan-Meier methods evaluated 2-year invasive disease-free survival rates for these 2 groups among patients treated with endocrine therapy (ET) alone. All analytical validation and reproducibility studies achieved point estimates of90% for negative, positive, and overall percent agreement. Intersite reproducibility produced point estimate values of 94.7%, 100.0%, and 97.3%. External interobserver reproducibility produced point estimate values of 98.9%, 97.8%, and 98.3%. Among 1954 patients receiving ET alone, 986 (50.5%) had high and 968 (49.5%) had low Ki-67 expression. Patients with high Ki-67 had a clinically meaningful increased risk of developing invasive disease within 2 years compared with those with low Ki-67 [2-y invasive disease-free survival rate: 86.1% (95% confidence interval: 83.1%-88.7%) vs. 92.0% (95% confidence interval: 89.7%-93.9%), respectively]. This standardized Ki-67 methodology resulted in high concordance across multiple laboratories, and its use in the monarchE study prospectively demonstrated the prognostic value of Ki-67 IHC in HR+, HER2- early breast cancer with high-risk clinicopathologic features.
Published: 2021

223. Alterations in fast-twitch muscle membrane conductance regulation do not explain decreased muscle function of SOD1

Author: Pieter A, Leermakers, Martin, Skov, Anders, Riisager, Ole B, Nielsen, and Thomas H, Pedersen
Subjects: Motor Neurons, Disease Models, Animal, Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Humans, Muscle, Skeletal, Rats
Abstract: Both neuromuscular junction (NMJ) dysfunction and altered electrophysiological properties of muscle fibers have been reported in amyotrophic lateral sclerosis (ALS) patients. ALS-related preclinical studies typically use rodent SOD1Longitudinal studies of compound muscle action potentials (CMAPs) were performed in SOD1SOD1The current data suggest that loss of CMAP amplitude is largely explained by defects in either lower motor neuron or skeletal muscle with only minor indications of a role for neuromuscular transmission defects in SOD1
Published: 2021

224. Low plasma adiponectin in risk of type 2 diabetes: observational analysis and one- and two-sample Mendelian randomization analyses in 756,219 individuals

Author: Børge G. Nordestgaard, Marianne Benn, Yunus Çolak, and Maria B. Nielsen
Abstract: We tested the hypothesis that low plasma adiponectin is observationally and genetic, causally associated with increased risk of type 2 diabetes. Observational analyses are prone to confounding and reverse causation, while genetic Mendelian randomization analyses are much less influenced by these biases. We examined 30,045 Copenhagen individuals observationally (1,751 type 2 diabetes; plasma adiponectin), 96,903 Copenhagen individuals using one-sample Mendelian randomization (5,012 type 2 diabetes; five genetic variants), and 659,316 Europeans (ADIPOGen, GERA, DIAGRAM, UK Biobank) using two-sample Mendelian randomization (62,892 type 2 diabetes; ten genetic variants). Observationally, and compared to individuals with median plasma adiponectin of 28.9µg/mL(4th quartile), multivariable adjusted hazard ratios for type 2 diabetes were 1.42(95% CI:1.18-1.72) for 19.2µg/mL(3rd quartile), 2.21(1.84-2.66) for 13.9µg/mL(2nd quartile), and 4.05(3.38-4.86) for 9.2µg/mL(1st quartile). Corresponding cumulative incidences for type 2 diabetes at age 70 were 3%, 7%, 11%, and 20%, respectively. A 1µg/mL lower plasma adiponectin conferred a hazard ratio for type 2 diabetes of 1.07(1.06-1.09), while genetic, causal risk ratios per 1 unit log-transformed lower plasma adiponectin were 1.13(0.83-1.53) in one-sample Mendelian randomization and 1.26(1.01-1.57) in two-sample Mendelian randomization. In conclusion, low plasma adiponectin is associated with increased risk of type 2 diabetes, an association that could represent a causal relationship.
Published: 2021

225. Multi length scale porosity as a playground for organic thermoelectric applications

Author: Quentin Weinbach, Christian B. Nielsen, Laure Biniek, Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Conductive polymer, Materials science, Context (language use), Nanotechnology, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Thermoelectric materials, 7. Clean energy, 01 natural sciences, 0104 chemical sciences, Thermal conductivity, 13. Climate action, Waste heat, Thermoelectric effect, Materials Chemistry, [CHIM]Chemical Sciences, 0210 nano-technology, Porous medium, Porosity
Abstract: Porous organic materials have interesting materials properties governed not only by their covalent structure but also by their intrinsic porosity which when controlled over multiple length scales gives rise to micro-, meso- and macroporous materials. These materials have been exploited for many years in applications such as gas storage, filtration/separation membranes, or support for catalysts. More recently, porous materials have attracted significant attention as potential harvesters of the abundant waste heat generated in today's society. Taking advantage of the thermoelectric effect, whereupon a temperature gradient is converted to electric voltage, thermoelectric materials and their associated applications are well-suited for this endeavor. Efficient thermoelectric materials must combine a high electrical conductivity and a low thermal conductivity. Since in porous materials, these properties can potentially be optimized independently, they are intriguing candidates for further exploration. Here, we give an overview of the different classes of porous conducting polymers (PCPs) and provide a thorough survey of their recent use in the broader context of thermoelectrics. We also aim to identify the major challenges and future perspectives for porous organic thermoelectric materials.
Published: 2021

226. Thermoelectric Materials: Current Status and Future Challenges

Author: Oliver Fenwick, Emiliano Bilotti, Peter A. Finn, Ceyla Asker, Kening Wan, and Christian B. Nielsen
Subjects: Organic semiconductor, Materials science, Doping, Current (fluid), Thermoelectric materials, Engineering physics
Published: 2021

227. Testing Denmark: A Danish nationwide surveillance study of COVID-19

Author: Susanne Dam Nielsen, Anders Koch, Rasmus Bo Hasselbalch, Jarl Emanuel Strange, Alexandra Rr Eriksen, Fredrik Folke, Berit Andersen, Robert Skov, Christian Erikstrup, Charlotte Svaerke Joergensen, Steen Ethelberg, Anders Formsgaard, Kaare Moelbak, Ute Wolff Sönksen, Isik Somuncu Johansen, Lothar Wiese, Pernille B Nielsen, Lars Oestergaard, Kasper Iversen, Jakob B Norsk, Anne-Marie Vangsted, Henrik Ullum, Svend Ellermann-Eriksen, Jonas H Kristensen, Lone Simonsen, Thea Kølsen Fischer, Freddy Lippert, Tyra Grove Krause, Henning Bundgaard, Sisse R. Ostrowski, Kamille Fogh, Henrik Nielsen, Bibi Fss Scharff, and Thomas Benfield
Subjects: Coronavirus disease 2019 (COVID-19), business.industry, Point-of-care testing, language.human_language, Test (assessment), Danish, Interquartile range, Relative risk, Pandemic, language, Medicine, Seroprevalence, business, Demography
Abstract: BackgroundNational data on the spread of SARS-CoV-2 infection and knowledge on associated risk factors are important for understanding the course of the pandemic. “Testing Denmark” is a national large-scale epidemiological surveillance study of SARS-CoV-2 in the Danish population.MethodsBetween September and October 2020, approximately 1.3 million of 5.8 million Danish citizens (age > 15 years) were randomly invited to fill in an electronic questionnaire covering COVID-19 exposures and symptoms. The prevalence of SARS-CoV-2 antibodies was determined by Point-of Care rapid Test (POCT) distributed to participants home addresses.FindingsIn total 318,552 participants (24.5% invitees) completed the questionnaire and provided the result of the POCT. Of these, 2,519 (0.79%) were seropositive (median age 55 years) and women were more often seropositive than men, interquartile range (IQR) 42-64, 40.2% males. Of participants with a prior positive Polymerase Chain Reaction (PCR) test (n=1,828), 29.1% were seropositive in the POCT. Seropositivity increased with age irrespective of sex. Elderly participants (>61 years) reported less symptoms and had less frequently been tested for SARS-CoV-2 compared to younger participants. Seropositivity was associated with physical contact with SARS-CoV-2 infected individuals (Risk ratio (RR) 7.43, 95% CI: 6.57-8.41) and in particular household members (RR 17.70, 95% CI: 15.60-20.10). Home care workers had a higher risk of seropositivity (RR 2.09 (95% CI: 1.58-2.78) as compared to office workers. Geographic population density was not associated to seropositivity. A high degree of compliance with national preventive recommendations was reported (e.g., > 80% use of face masks), but no difference was found between seropositive and seronegative participants.InterpretationThis study provides insight into the immunity of the Danish population seven to eight months after the first COVID-19 case in Denmark. The seroprevalence was lower than expected probably due to a low sensitivity of the POCT used or due to challenges relating to the reading of test results. Occupation or exposure in local communities were major routes of infection. As elderly participants were more often seropositive despite fewer symptoms and less PCR tests performed, more emphasis should be placed on testing this age group.
Published: 2021

228. Anti-SARS-CoV-2 Seropositivity Among Medical Students in Copenhagen

Author: Rasmus Bo Hasselbalch, Kasper Iversen, Peter Garred, Pernille B Nielsen, Cecilie Bo Hansen, Johannes R. Madsen, Jacob P. S. Nielsen, Theis Lange, and Kamille Fogh
Subjects: medicine.medical_specialty, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), education, Population, medical students, Social behaviour, health care workers, Major Articles, Danish, coronavirus disease 2019, Internal medicine, Health care, medicine, Seroprevalence, education.field_of_study, seroprevalence, biology, Transmission (medicine), business.industry, Venous blood sample, Attendance, Odds ratio, language.human_language, AcademicSubjects/MED00290, Infectious Diseases, Oncology, Immunoglobulin M, Family medicine, Cohort, biology.protein, language, business, anti-SARS-CoV-2 antibodies, Blood drawing
Abstract: Background Health care workers are at a higher risk of getting infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population. Knowledge about medical students’ exposure to SARS-CoV-2 is lacking. Thus, we measured the prevalence of SARS-CoV-2 antibodies in a cohort of Danish medical students. Methods We invited all medical students at the University of Copenhagen (UCPH) to participate. Students underwent venous blood sampling and a questionnaire about work-life behaviors possibly associated with SARS-CoV-2 exposure and coronavirus disease 2019 (COVID-19) symptoms. Samples were analyzed for total immunoglobulin G (IgG) antibodies against SARS-CoV-2, and seropositive samples were screened for IgG, immunoglobulin M, and immunoglobulin A antibodies. We determined associations between seropositivity and clinical and social activities and self-reported symptoms. Results Between October 19 and 26, 1120 students participated in the questionnaire and 1096 were included. Of all included, 379 (34.58%) were seropositive. Seropositivity was associated with attendance at 2 parties at UCPH, on February 29 and March 6, 2020 (odds ratio [OR], 5.96; 95% CI, 4.34–8.24; P Conclusions Medical students have the highest reported seropositivity in the Danish health care system. In this cohort of students at UCPH, seropositivity was associated with social behavior markers and, to a lesser extent, with self-reported contact with SARS-CoV-2-infected patients.
Published: 2021

229. Off-state bias stress stability in polymer transistors: An often overlooked prerequisite

Author: Iain McCulloch, Malgorzata Nguyen, Henning Sirringhaus, Ulrike Kraft, and Christian B. Nielsen
Subjects: chemistry.chemical_classification, Materials science, chemistry, law, Transistor, State (functional analysis), Polymer, Stability (probability), Engineering physics, Bias stress, law.invention
Published: 2021

230. Multilabel hybridization probes for sequence-specific detection of sepsis-related drug resistance genes in plasmids

Author: Elaine Lazalde, Adam T. Woolley, Robert L. Hanson, Yesman Akuoko, David H. Harris, Jacob B. Nielsen, and Radim Knob
Subjects: Streptavidin, Multilabel fluorescence, QD71-142, DNA hybridization, Drug resistance, Article, chemistry.chemical_compound, Plasmid, chemistry, Biotin, Biochemistry, Plasmid detection, Polynucleotide, Nucleic acid, Gene, Analytical chemistry, DNA, Sequence-specific hybridization
Abstract: Emerging antimicrobial drug resistance is increasing the complexity involved in treating critical conditions such as bacterial induced sepsis. Methods for diagnosing specific drug resistance tend to be rapid or sensitive, but not both. Detection methods like sequence-specific single-molecule analysis could address this concern if they could be adapted to work on smaller targets similar to those produced in traditional clinical situations. In this work we demonstrate that a 120 bp double stranded polynucleotide with an overhanging single stranded 25 bp probe sequence can be created by immobilizing DNA with a biotin/streptavidin magnetic bead system, labeling with SYBR Gold, and rinsing the excess away while the probe retains multiple fluorophores. These probes with multiple fluorophores can then be used to label a bacterial plasmid target in a sequence-specific manner. These probes enabled the detection of 1 pM plasmid samples containing a portion of an antibiotic resistance gene sequence. This system shows the possibility of improving capture and fluorescence labeling of small nucleic acid fragments, generating lower limits of detection for clinically relevant samples while maintaining rapid processing times.
Published: 2021

231. Spatially Adaptive Volume Tools in Bifrost

Author: Konstantinos Stamatelos, Robert Bridson, Morten Bojsen-Hansen, and Michael B. Nielsen
Subjects: Level set, Level set method, Matching (graph theory), Sampling (signal processing), Computer science, Voxel, Volume (computing), Polygon mesh, computer.software_genre, computer, ComputingMethodologies_COMPUTERGRAPHICS, Interpolation, Computational science
Abstract: The level set method offers many advantages over e.g. meshes for modelling and visual effects, but a naive implementation is both computationally expensive and memory intensive. Narrow band level sets alleviate both issues but are still limited by the finest detail resolved due to uniform resolution along the surface. Voxel structures that are adaptive along the surface improve this [Frisken et al. 2000], but have not seen wide adoption. This is presumably due to difficulties matching the performance of optimized narrow band implementations like industry standard OpenVDB [Museth 2013]. We present the adaptive level set implementation in Bifrost which is competitive with OpenVDB in speed while offering lower memory usage thanks to spatial adaptivity. Our contributions include novel algorithms for adaptive sharpened B-spline interpolation of volumes in general, voxelizing meshes and points into adaptive level set volumes, and meshing adaptive level sets.
Published: 2021

232. Oncological results and morbidity following intended curative resection and free jejunal graft reconstruction of cervical esophageal cancer: a retrospective Danish consecutive cohort study

Author: Josefine Slater, Daniel Kjær, Arunas Pikelis, Torben Ingemann Petersen, M. B. Nielsen, Birgitte Jul Kiil, Sune Brinck Erichsen, Marianne Nordsmark, and Niels Katballe
Subjects: Curative resection, medicine.medical_specialty, Future studies, Esophageal Neoplasms, CARCINOMA, Denmark, Locally advanced, morbidity, cervical esophageal cancer, Chemoradiotherapy/methods, Cohort Studies, Danish, ESOPHAGOGASTRIC JUNCTION, 03 medical and health sciences, 0302 clinical medicine, MANAGEMENT, medicine, Humans, Retrospective Studies, business.industry, Mortality rate, Gastroenterology, oncological results, Chemoradiotherapy, free jejunal graft, General Medicine, Esophageal cancer, medicine.disease, Denmark/epidemiology, language.human_language, Surgery, 030220 oncology & carcinogenesis, pharyngolaryngectomy, language, 030211 gastroenterology & hepatology, Morbidity, Esophageal Neoplasms/drug therapy, business, RADIOTHERAPY, Neoadjuvant chemoradiotherapy, Cohort study
Abstract: Summary Background The role of surgery in treatment of locally advanced cervical esophageal cancer (CEC) remains debated. In the European and American treatment guidelines, definitive chemoradiotherapy (dCRT) is preferred over surgery, while in the Danish guidelines, the two treatment modalities are equally recommended. Surgical treatment of CEC is centralized at our center in Denmark. We present our outcomes following neoadjuvant chemoradiotherapy (nCRT) when possible and resection as first-line therapy for CEC and compare with recent published dCRT results. Method We retrospectively reviewed the medical charts of patients treated for cervical esophageal cancer at Aarhus University Hospital from 2001–2018 with nCRT when possible and pharyngolaryngectomy followed by reconstruction with a free jejunal graft. Results Forty consecutive patients were included. About, 45% received nCRT. The median survival was 21 months. The overall, disease-specific and disease-free 5-year survival was 43.6%, 53.2%, and 47.4%, respectively. The rate of microscopically radical resection was 85%. The recurrence rate was 47% and 81% of recurrences were locoregional. The in-hospital and 30-day mortality rate was 0%. Major complications occurred in 27.9%. Anastomotic leakage, graft failure, fistulas and strictures occurred in 10%, 7.5%, 30%, and 30%, respectively. Conclusion Our treatment offers equal oncological results compared to the best internationally published results for dCRT for CEC. Results vary considerably between dCRT studies. Morbidity appears more pronounced following surgery. Future studies are warranted to investigate the Danish national outcomes following dCRT as first-line treatment for curable locally advanced CEC.
Published: 2021

233. Effect of Addition of Tryptophan on Aggregation of Apo-α-Lactalbumin Induced by UV-Light

Author: Zichen Zhao, Marianne N. Lund, Mahesha M. Poojary, Renjie Li, and Søren B. Nielsen
Subjects: WHEY PROTEINS, Whey protein, Health (social science), Plant Science, Oxidative phosphorylation, TP1-1185, CYSTINE, Cleavage (embryo), 01 natural sciences, Health Professions (miscellaneous), Microbiology, Article, chemistry.chemical_compound, 0404 agricultural biotechnology, EXCITED-STATE CHEMISTRY, Photosensitizer, tryptophan, PHOTOLYSIS, UV illumination, AROMATIC-AMINO-ACIDS, Lactalbumin, 010405 organic chemistry, Chemical technology, photooxidation, Tryptophan, aggregation, PEPTIDES, 04 agricultural and veterinary sciences, whey protein, 040401 food science, 0104 chemical sciences, BONDS, chemistry, Biophysics, Anaerobic exercise, Kynurenine, Food Science
Abstract: UV-B illumination facilitates aggregation of alpha-lactalbumin (alpha-LA) by intramolecular disulfide bond cleavage followed by intermolecular thiol-disulfide exchange reactions. However, long term exposure to UV-B illumination may induce undesired oxidative modifications of amino acid residues in the protein. The purpose of this study was to examine the effect of UV-induced aggregation of apo-alpha-LA (a calcium-depleted form of alpha-LA) under aerobic and anaerobic conditions and by addition of tryptophan (Trp) as a photosensitizer. The addition of Trp to apo-alpha-LA illuminated under anaerobic conditions facilitated the highest level of free thiol release and disulfide-mediated aggregation as compared to without addition of Trp under both anaerobic and aerobic conditions. Addition of Trp under aerobic condition resulted in the lowest level of free thiols and disulfide-mediated aggregation and the aerobic conditions caused oxidation of the free Trp with formation of kynurenine and 5-hydroxy-Trp. Minor levels of the Trp oxidation product, 3-hydroxy-kynurenine (2% converted from Trp), was formed in apo-alpha-LA with added Trp under both aerobic and anaerobic conditions after UV-B treatment.
Published: 2021
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234. Utility of family history in disease prediction in the era of polygenic scores

Author: Wei Zhou, Ida Surakka, Ben Michael Brumpton, Cristen J. Willer, Nicholas J. Douville, Sarah E. Graham, Hyun Min Kang, Kristian Hveem, Brooke N. Wolford, Lars G. Fritsche, Boehnke M, Seunggeun Lee, Anne Heidi Skogholt, Jonas B. Nielsen, Whitney E. Hornsby, and Maiken Elvestad Gabrielsen
Subjects: medicine.medical_specialty, business.industry, High resolution, Disease, Type 2 diabetes, medicine.disease, Biobank, Patient care, Coronary artery disease, Prediction algorithms, medicine, Family history, Intensive care medicine, business
Abstract: Clinicians have historically used family history and other risk prediction algorithms to guide patient care and preventive treatment such as statin therapeutics for coronary artery disease. As polygenic scores move towards clinical use, we have begun to consider the interplay of these scores with other predictors for optimal second generation risk prediction. Here, we assess the use of family history and polygenic scores as independent predictors of coronary artery disease and type 2 diabetes. We highlight considerations for use of family history as a predictor of these two diseases after evaluating their effectiveness in the Trøndelag Health Study and the UK Biobank. From these, we advocate for collection of high resolution family history variables in biobanks for future prediction models.
Published: 2021

235. Anyon braiding on a fractal lattice with a local Hamiltonian

Author: Sourav Manna, Callum W. Duncan, Carrie A. Weidner, Jacob F. Sherson, and Anne E. B. Nielsen
Subjects: Condensed Matter - Strongly Correlated Electrons, Strongly Correlated Electrons (cond-mat.str-el), Quantum Gases (cond-mat.quant-gas), FOS: Physical sciences, Condensed Matter - Quantum Gases, QC
Abstract: There is a growing interest in searching for topology in fractal dimensions with the aim of finding different properties and advantages compared to the integer dimensional case. Here, we construct a local Hamiltonian on a fractal lattice whose ground state exhibits topological braiding properties. The fractal lattice is obtained from a second generation Sierpinski carpet with Hausdorff dimension 1.89. We use local potentials to trap and exchange anyons in the model, and the numerically obtained results for the exchange statistics of the anyons are close to the ideal statistics for quasiholes in a bosonic Laughlin state at half filling. For the considered system size, the energy gap is about three times larger for the fractal lattice than for a two-dimensional square lattice, and we find that the braiding results obtained on the fractal lattice are more robust against disorder. We propose a scheme to implement both fractal lattices and our proposed local Hamiltonian with ultracold atoms in optical lattices., 6 pages, 2 figures, accepted version
Published: 2021

236. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Author: Helgadottir A, Giannakopoulou O, Costanzo Mc, Heribert Schunkert, Giardoglou P, Markus M. Nöthen, Zhou W, Thomas Meitinger, Deepak Atri, Murgia F, Amit Khera, Tao Jiang, Munz M, Jeanette Erdmann, Patrick T. Ellinor, Marju Orho-Melander, Rajat M. Gupta, Kazuyoshi Ishigaki, Satoshi Koyama, Güldener U, Dongkeun Jang, Hilary K. Finucane, George Hindy, George Dedoussis, Cristen J. Willer, Johan L.M. Björkegren, Aris Baras, Marc S. Sabatine, Flannick J, Arno Ruusalepp, Alanna C. Morrison, Danesh J, Christopher P. Nelson, Nicholas A Marston, Thorgeirsson G, Ida Surakka, Sherliker P, Kastrati A, Ibrahim M, Ito K, Robert Clarke, Christopher Grace, Minxian Wang, Boerwinkle E, Haider Smi, Anuj Goel, Ben Michael Brumpton, Lijiang Ma, Sekar Kathiresan, Li L, Pang S, Carolina Roselli, Issei Komuro, de Vries Ps, Kristian Hveem, Hilma Holm, Adam S. Butterworth, Lotta La, Panagiotis Deloukas, Unnur Thorsteinsdottir, Thorsten Kessler, Kamanu Fk, Roberts R, Arnar Do, Tom R. Webb, Ulirsch Jk, Jonas B. Nielsen, Reinberger T, Martin Farrall, Daniel F. Gudbjartsson, Elle M. Weeks, Kari Stefansson, Brooke N. Wolford, Krishna G. Aragam, Hugh Watkins, von Scheidt M, Yoichiro Kamatani, Pierre Zalloua, Christian T. Ruff, Muñoz Venegas L, Iftikhar J. Kullo, Gudmar Thorleifsson, Stavroula Kanoni, Olle Melander, Nilesh J. Samani, Michael R. Brown, Loukianos S. Rallidis, Jemma C. Hopewell, and Mucha S
Subjects: Coronary artery disease, Pathogenesis, medicine, CAD, Genome-wide association study, Vascular proliferation, Computational biology, Biology, Disease pathogenesis, medicine.disease, Gene
Abstract: Rapid progress of the discovery of genetic loci associated with common, complex diseases has outpaced the elucidation of mechanisms pertinent to disease pathogenesis. To address relevant barriers for coronary artery disease (CAD), we combined genetic discovery analyses with downstream characterization of likely causal variants, genes, and biological pathways. Specifically, we conducted a genome-wide association study (GWAS) comprising 181,522 cases of CAD among 1,165,690 participants. We detected 241 associations, including 54 associations and 30 loci not previously linked to CAD. Next, we prioritized likely causal variants using functionally-informed fine-mapping, yielding 42 associations with fewer than five variants in the 95% credible set. Combining eight complementary predictors, we prioritized 185 candidate causal genes, including 94 genes supported by three or more predictors. Similarity-based clustering underscored a role for early developmental processes, cell cycle signaling, and vascular proliferation in the pathogenesis of CAD. Our analysis identifies and systematically characterizes risk loci for CAD to inform experimental interrogation of putative causal mechanisms for CAD.
Published: 2021

237. Author response for 'Greenhouse gases emissions in liquified natural gas as a marine fuel: Life cycle analysis and reduction potential'

Author: Ahmad Al-Douri, Rasmus B Nielsen, Margaux Moore, Amro A. El-Baz, Mahmoud M. El-Halwagi, and Abdulrahman S. Alsuhaibani
Subjects: Reduction (complexity), Waste management, Greenhouse gas, Environmental science, Marine fuel, Liquefied natural gas
Published: 2021

238. Comparison of the three-level and the five-level versions of the EQ-5D

Author: Søren Zöga Diederichsen, Anders G. Holst, Anne Simone Juhl Christiansen, Claus Graff, Søren Højberg, Marie Louise Sletskov Møller, Christian Kronborg, Lars Køber, Axel Brandes, Jonas B. Nielsen, Jesper Hastrup Svendsen, Ketil Haugan, and Derk Krieger
Subjects: medicine.medical_specialty, Health-related quality of life, Economics, Econometrics and Finance (miscellaneous), Population, Ceiling (cloud), Correlation, 03 medical and health sciences, 0302 clinical medicine, Quality of life, EQ-5D, medicine, 030212 general & internal medicine, education, education.field_of_study, business.industry, 030503 health policy & services, Health Policy, medicine.disease, Comorbidity, EQ-5D-3L, EQ-5D-5L, Convergent validity, Physical therapy, Ceiling effect, 0305 other medical science, business, Measurement properties
Abstract: EQ-5D is a generic instrument to measure health-related quality of life. In 2009, a new version, EQ-5D-5L, was introduced as an attempt to reduce ceiling effects and improve sensitivity to small changes over time. The objective of this study was to assess the measurement properties of the EQ-5D-5L instrument compared to the EQ-5D-3L instrument in an elderly general population with a moderate to a high degree of comorbidity. A subgroup of participants in a large clinical trial completed the EQ-5D-3L and the EQ-5D-5L questionnaires. Based on the collected data, we tested for feasibility and ceiling and floor effects. Furthermore, we assessed the redistribution properties of the responses and examined the level of inconsistency, informativity, and convergent validity. A total of 1002 persons diagnosed with hypertension, diabetes, heart failure, and/or previous stroke completed both the EQ-5D-3L and the EQ-5D-5L questionnaires. The overall ceiling effect decreased from 46% with the EQ-5D-3L to 30% with the EQ-5D-5L and absolute and relative informativity were higher for EQ-5D-5L, and there was a stronger correlation between EQ-5D-5L and EQ VAS. The EQ-5D-5L seemed to perform better than the EQ-5D-3L in terms of feasibility, ceiling effect, discriminatory power, and convergent validity. The overall ceiling effect was higher than that found in patient samples in previous studies but lower than the one found in population studies.
Published: 2021

239. Exploring and visualizing large-scale genetic associations by using PheWeb

Author: Ryan P. Welch, Ellen M. Schmidt, Jonas B. Nielsen, Peter VandeHaar, Cristen J. Willer, Andrew P. Boughton, Gonçalo R. Abecasis, Daniel Taliun, Wei Zhou, Lars G. Fritsche, Michael Boehnke, Seunggeun Lee, and Sarah A Gagliano Taliun
Subjects: Scale (ratio), business.industry, Extramural, Data Visualization, MEDLINE, Genome-wide association study, Computational biology, Biology, Polymorphism, Single Nucleotide, Article, User-Computer Interface, Data visualization, Urinary Bladder Neoplasms, Genetics, Humans, business, Software, Genome-Wide Association Study
Published: 2020

240. Microfluidics: Innovations in Materials and Their Fabrication and Functionalization

Author: Jacob B. Nielsen, Adam T. Woolley, Haifa M. Almughamsi, Chao Pang, Taylor R Fish, and Robert L. Hanson
Subjects: Physics, Ceramics, Silicon, Fabrication, Polymers, Extramural, Microfluidics, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Nanotechnology, Microfluidic Analytical Techniques, Article, Analytical Chemistry, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Surface modification, Glass, ComputingMilieux_MISCELLANEOUS
Abstract: [Image: see text]
Published: 2019

241. The relationship between serum potassium concentrations and electrocardiographic characteristics in 163,547 individuals from primary care

Author: Adrian Pietersen, Jonas B. Nielsen, Peter Søgaard, Anders G. Holst, Claus Graff, Regitze Kuhr Skals, Jørgen K. Kanters, Maria Lukács Krogager, Christoffer Polcwiartek, Steen Møller Hansen, Kristian Kragholm, Christian Torp-Pedersen, and Rikke Nørmark Mortensen
Subjects: medicine.medical_specialty, Morphology combination score, Potassium, chemistry.chemical_element, QTc interval, Primary care, 030204 cardiovascular system & hematology, Serum potassium measurement, QT interval, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, P-wave amplitude, Internal medicine, Humans, Medicine, In patient, 030212 general & internal medicine, PR interval, P-wave duration, T-wave amplitude, Primary Health Care, ECG, business.industry, Serum potassium, Arrhythmias, Cardiac, chemistry, Concomitant, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: AIMS: Potassium disturbances are common and associated with increased morbidity and mortality, even in patients without prior cardiovascular disease. We examined six electrocardiographic (ECG) measures and their association to serum potassium levels.METHODS AND RESULTS: From the Copenhagen General Practitioners' Laboratory, we identified 163,547 individuals aged ≥16 years with a first available ECG and a concomitant serum potassium measurement during 2001-2011. Restricted cubic splines curves showed a non-linear relationship between potassium and the Fridericia corrected QT (QTcF) interval, T-wave amplitude, morphology combination score (MCS), PR interval, P-wave amplitude and duration. Therefore, potassium was stratified in two intervals K: 2.0-4.1 mmol/L and 4.2-6.0 mmol/L for further analyses. Within the low potassium range, we observed: QTcF was 12.8 ms longer for each mmol/L decrease in potassium (p
Published: 2019

242. Analysis of thrombin‐antithrombin complex formation using microchip electrophoresis and mass spectrometry

Author: Richard H. Carson, Jacob B. Nielsen, John C. Price, Daniel N. Mortensen, Robert L. Hanson, Adam T. Woolley, Anna V. Nielsen, Mukul Sonker, and Hsien-Jung L Lin
Subjects: Point-of-Care Systems, viruses, Antithrombin III, Clinical Biochemistry, Dot blot, macromolecular substances, 02 engineering and technology, Mass spectrometry, environment and public health, 01 natural sciences, Biochemistry, Mass Spectrometry, Article, Analytical Chemistry, Electrophoresis, Microchip, Health problems, Limit of Detection, Humans, integumentary system, Chemistry, 010401 analytical chemistry, Thrombin–antithrombin complex, Take over, 021001 nanoscience & nanotechnology, Molecular biology, 0104 chemical sciences, Microchip Electrophoresis, Biomarker (medicine), 0210 nano-technology, Biomarkers, Peptide Hydrolases
Abstract: Preterm birth (PTB) related health problems take over one million lives each year, and currently, no clinical analysis is available to determine if a fetus is at risk for PTB. Here, we describe the preparation of a key PTB risk biomarker, thrombin-antithrombin (TAT), and characterize it using dot blots, mass spectrometry, and microchip electrophoresis (μCE). The pH for fluorescently labeling TAT was also optimized using spectrofluorometry and spectrophotometry. The LOD of TAT was measured in μCE. Lastly, TAT was combined with six other PTB risk biomarkers and separated in μCE. The ability to make and characterize TAT is an important step toward the development of an integrated microfluidic diagnostic for PTB risk.
Published: 2019

243. Effects of an MRI Try Without program on patient access

Author: David B Nielsen, Amie L Robinson, Barbra S. Rudder, Janelle R Noel-Macdonnell PhD, and Sara J Easley
Subjects: Male, medicine.medical_specialty, Time Factors, Waiting Lists, Sedation, Conscious Sedation, Neuroradiologist, Sensitivity and Specificity, Health Services Accessibility, 030218 nuclear medicine & medical imaging, Cohort Studies, Appointments and Schedules, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Chart review, medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Child, Retrospective Studies, Neuroradiology, medicine.diagnostic_test, business.industry, Electronic medical record, Magnetic resonance imaging, Magnetic Resonance Imaging, Wait time, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Child life specialist
Abstract: Pediatric patients are often sedated for magnetic resonance imaging (MRI) scans to ensure images are of diagnostic quality. However, access time for MRIs requiring sedation is often long due to high patient volumes and limited sedation resources. This study examined the effectiveness of an MRI Try Without sedation program to decrease the wait time for obtaining an MRI while simultaneously ensuring diagnostic-quality images. A retrospective chart review was performed on subjects who utilized the MRI Try Without program from April 2014 through June 2015 at a dedicated pediatric institution. Child life specialist preparations and access time (i.e. time from exam ordered to exam completed) were recorded in each patient’s electronic medical record. MRI images were evaluated for image quality by a pediatric neuroradiologist. A total of 134 patients participated in the MRI Try Without program (mean age: 6.9±1.7 years), all of whom received interventions from a child life specialist. The average number of days between when the order was placed and when the MRI was completed using the MRI Try Without program was 15.4±18.5 days, while the third-available appointment for sedation/anesthesia was 46.2 days (standard deviation [SD]±15.7 days). Nearly all patients received a “good” or “very good” image quality determination (87.3%) and only 5 (3.8%) patients were recommended for repeat examination for diagnostic-quality images. Utilization of an MRI Try Without sedation program, with child life specialist interventions, decreased the wait time for obtaining an MRI while still providing diagnostic-quality images.
Published: 2019

244. The source of topography across the Cumberland Peninsula, Baffin Island, Arctic Canada: differential exhumation of a North Atlantic rift flank

Author: Scott Jess, Søren B. Nielsen, Randell Stephenson, and Roderick Brown
Subjects: Rift, 010504 meteorology & atmospheric sciences, Geology, 010502 geochemistry & geophysics, 01 natural sciences, Devonian, Cretaceous, Paleontology, Continental margin, Isostasy, Laurentia, Thermal history modelling, Cenozoic, 0105 earth and related environmental sciences
Abstract: Elevated topography is evident across the continental margins of the Atlantic. The Cumberland Peninsula, Baffin Island, formed as the result of rifting along the Labrador–Baffin margins in the late Mesozoic and is dominated by low-relief high-elevation topography. Apatite fission-track (AFT) analysis of the landscape previously concluded that the area has experienced a differential protracted cooling regime since the Devonian; however, defined periods of cooling and the direct causes of exhumation were unresolved. This work combines the original AFT data with 98 apatite new (U–Th)/He (AHe) ages from 16 samples and applies the newly developed ‘broken crystals’ technique to provide a greater number of thermal constraints for thermal history modelling to better constrain the topographic evolution. The spatial distribution of AFT and AHe ages implies that exhumation has been significant toward the SE (Labrador) coastline, and results of thermal modelling outline three notable periods of cooling: in the pre-rift stage (460–200 Ma), from synrift stage to present (120–0 Ma) and within the post-rift stage (30–0 Ma). Pre-rift cooling is interpreted as the result of exhumation of Laurentia and synrift cooling as the result of rift-flank uplift to the SE and differential erosion of landscape, whereas the final post-rift period is probably an artefact of the modelling process. These results suggest that the source of the Cumberland Peninsula9s modern-day elevated topography is uplift during rifting in the Cretaceous and the isostatic compensation following continuous Mesozoic and Cenozoic differential erosion. This work highlights how interaction of rift tectonics and isostasy can be the principal source for modern elevated continental margins, and also provides insight into the pre-rift exhumational history of central Laurentia. Supplementary material: Thermal histories are available at: https://doi.org/10.6084/m9.figshare.c.4528409
Published: 2019

245. Peptide‐Directed DNA‐Templated Protein Labelling for The Assembly of a Pseudo‐IgM

Author: Thorbjørn B. Nielsen, Rasmus P. Thomsen, Michael R. Mortensen, Jørgen Kjems, Per Franklin Nielsen, Thomas E. Nielsen, Anne Louise B. Kodal, Emiliano Cló, and Kurt V. Gothelf
Subjects: General Medicine
Published: 2019

246. Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria

Author: Sarah Hsieh, Ksenia Ershova, Eric P. Skaar, Luis A. Actis, Sue Rudin, Amber Ulhaq, Paul G. Ambrose, Brian VanScoy, Travis B. Nielsen, Brian Luna, Kristine M. Hujer, Jun Yan, Brad Spellberg, Paul Pantapalangkoor, and Robert A. Bonomo
Subjects: Microbiology (medical), Acinetobacter baumannii, Gram-negative bacteria, medicine.drug_class, Antibiotics, Drug resistance, Microbial Sensitivity Tests, medicine.disease_cause, Meropenem, Microbiology, 03 medical and health sciences, Antibiotic resistance, Ciprofloxacin, Drug Resistance, Bacterial, Gram-Negative Bacteria, medicine, Humans, Pharmacology (medical), 030304 developmental biology, Original Research, Pharmacology, 0303 health sciences, biology, 030306 microbiology, Transferrin, biology.organism_classification, 3. Good health, Anti-Bacterial Agents, Klebsiella pneumoniae, Infectious Diseases, Staphylococcus aureus, Mutation, Apoproteins, Gram-Negative Bacterial Infections, medicine.drug
Abstract: BackgroundNew strategies are needed to slow the emergence of antibiotic resistance among bacterial pathogens. In particular, society is experiencing a crisis of antibiotic-resistant infections caused by Gram-negative bacterial pathogens and novel therapeutics are desperately needed to combat such diseases. Acquisition of iron from the host is a nearly universal requirement for microbial pathogens—including Gram-negative bacteria—to cause infection. We have previously reported that apo-transferrin (lacking iron) can inhibit the growth of Staphylococcus aureus in culture and diminish emergence of resistance to rifampicin.ObjectivesTo define the potential of apo-transferrin to inhibit in vitro growth of Klebsiella pneumoniae and Acinetobacter baumannii, key Gram-negative pathogens, and to reduce emergence of resistance to antibiotics.MethodsThe efficacy of apo-transferrin alone or in combination with meropenem or ciprofloxacin against K. pneumoniae and A. baumannii clinical isolates was tested by MIC assay, time–kill assay and assays for the selection of resistant mutants.ResultsWe confirmed that apo-transferrin had detectable MICs for all strains tested of both pathogens. Apo-transferrin mediated an additive antimicrobial effect for both antibiotics against multiple strains in time–kill assays. Finally, adding apo-transferrin to ciprofloxacin or meropenem reduced the emergence of resistant mutants during 20 day serial passaging of both species.ConclusionsThese results suggest that apo-transferrin may have promise to suppress the emergence of antibiotic-resistant mutants when treating infections caused by Gram-negative bacteria.
Published: 2019

247. The age‐related reduction in cerebral blood flow affects vertebral artery more than internal carotid artery blood flow

Author: Niels D. Olesen, Henning B. Nielsen, Niels H. Secher, and Niels Vidiendal Olsen
Subjects: Adult, Male, Aging, Mean arterial pressure, medicine.medical_specialty, Ultrasonography, Doppler, Transcranial, Physiology, 030204 cardiovascular system & hematology, Patient Positioning, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine.artery, Supine Position, medicine, Humans, Arterial Pressure, Vertebral Artery, Aged, Sitting Position, business.industry, Age Factors, 030229 sport sciences, General Medicine, Oxygenation, Blood flow, Bicycling, Transcranial Doppler, Oxygen, Blood pressure, Cerebral blood flow, Cerebrovascular Circulation, Middle cerebral artery, Cardiology, Internal carotid artery, business, Blood Flow Velocity, Carotid Artery, Internal
Abstract: Ageing reduces cerebral blood flow (CBF), while mean arterial pressure (MAP) becomes elevated. According to 'the selfish brain' hypothesis of hypertension, a reduction in vertebral artery blood flow (VA) leads to increased sympathetic activity and thus increases MAP. In twenty-two young (24 ± 3 years; mean ± SD) and eleven elderly (70 ± 5 years) normotensive men, duplex ultrasound evaluated whether the age-related reduction in CBF affects VA more than internal carotid artery (ICA) blood flow. Pulse-contour analysis evaluated MAP while near-infrared spectroscopy determined frontal lobe oxygenation and transcranial Doppler middle cerebral artery mean blood velocity (MCA Vmean ). During supine rest, MAP (90 ± 13 versus 78 ± 9 mmHg; P
Published: 2019

248. Determination of thermal properties of materials by Monte Carlo inversion of pulsed needle probe data

Author: Niels Balling, Thue S. Bording, and Søren B. Nielsen
Subjects: Materials science, Monte Carlo method, 02 engineering and technology, Thermal diffusivity, 01 natural sciences, 010305 fluids & plasmas, symbols.namesake, Thermal conductivity, 0103 physical sciences, Thermal, Ceramic, Fluid Flow and Transfer Processes, Numerical forward model, Mechanical Engineering, Markov chain Monte Carlo, Mechanics, 021001 nanoscience & nanotechnology, Condensed Matter Physics, visual_art, visual_art.visual_art_medium, symbols, Uncertainty analysis, Needle probe, Heat equation, Monte Carlo inversion, 0210 nano-technology, Material properties
Abstract: Needle probe measurements are used in a wide variety of fields for measuring the thermal conductivity of materials. It is most common to extract the thermal conductivity from the temperature rise data using the asymptotic solution to the heat equation. With special reference to, but not limited to Earth materials, this study presents an inversion procedure using pulsed needle probe data to determine both thermal conductivity and thermal diffusivity. The measured temperature response data are interpreted using a finite element forward model and a Markov Chain Monte Carlo inversion algorithm. The thermal properties of the needle probe are part of the forward model and determined by measurements on calibration standards. We examine several factors by synthetic modelling and quantify their effects by Monte Carlo inversions. This include (1) the heat production rate of the probe in order to produce similar temperature increases in materials of different thermal properties, (2) the contact resistance between needle probe and sample, (3) the limitations imposed by sample diameter and the thermal properties of the surrounding medium, and (4) the duration of heating period required to obtain good results. Laboratory test measurements on selected materials (water, glycerol, ceramic standard, clay) demonstrate good agreement with expected values obtained from literature. We demonstrate that the combination of numerical forward modelling and Monte Carlo inversion, applied to the pulsed needle, is a flexible and powerful methodology for accurate laboratory measurements of material thermal properties and with well-defined estimates of uncertainty. With the given equipment and laboratory setup, thermal conductivity is measured to within few percent, while thermal diffusivity generally has a somewhat higher degree of uncertainty, up to about five percent.
Published: 2019

249. MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM

Author: Ashish Kalra, Jeffrey D. Kearns, Adnan O. Abu-Yousif, Gavin MacBeath, Alexey Lugovskoy, Maria Håkansson, Derek T. Logan, Birgit Schoeberl, Martin Welin, Melissa Geddie, Ulrik B. Nielsen, Neeraj Kohli, Tim Maiwald, Jessica B. Casaletto, Aaron Fulgham, Brian Harms, Shrikanta Chattopadhyay, Stephen Su, Maja Razlog, Antoine Boudot, Kristina Masson, and Andreas Raue
Subjects: medicine.drug_class, Monoclonal antibody, Mice, chemistry.chemical_compound, Antineoplastic Agents, Immunological, Antigen, Cell Line, Tumor, Antibodies, Bispecific, medicine, Animals, Humans, Binding site, Receptor, Multidisciplinary, biology, Hepatocyte Growth Factor, Chemistry, Epithelial cell adhesion molecule, Neoplasms, Experimental, Proto-Oncogene Proteins c-met, Epithelial Cell Adhesion Molecule, Xenograft Model Antitumor Assays, PNAS Plus, Cancer cell, Cancer research, biology.protein, Hepatocyte growth factor, Antibody, Signal Transduction, medicine.drug
Abstract: Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, metastasis, and resistance to therapy. Clinical development of Met-targeted antibodies has been challenging, however, as bivalent antibodies exhibit agonistic properties, whereas monovalent antibodies lack potency and the capacity to down-regulate Met. Through computational modeling, we found that the potency of a monovalent antibody targeting Met could be dramatically improved by introducing a second binding site that recognizes an unrelated, highly expressed antigen on the tumor cell surface. Guided by this prediction, we engineered MM-131, a bispecific antibody that is monovalent for both Met and epithelial cell adhesion molecule (EpCAM). MM-131 is a purely antagonistic antibody that blocks ligand-dependent and ligand-independent Met signaling by inhibiting HGF binding to Met and inducing receptor down-regulation. Together, these mechanisms lead to inhibition of proliferation in Met-driven cancer cells, inhibition of HGF-mediated cancer cell migration, and inhibition of tumor growth in HGF-dependent and -independent mouse xenograft models. Consistent with its design, MM-131 is more potent in EpCAM-high cells than in EpCAM-low cells, and its potency decreases when EpCAM levels are reduced by RNAi. Evaluation of Met, EpCAM, and HGF levels in human tumor samples reveals that EpCAM is expressed at high levels in a wide range of Met-positive tumor types, suggesting a broad opportunity for clinical development of MM-131.
Published: 2019

250. Investigation of the thermoelectric response in conducting polymers doped by solid-state diffusion

Author: Keehoon Kang, David Harkin, Katharina Broch, Cameron Jellett, Henning Sirringhaus, Sam Schott, Iain McCulloch, Guillaume Schweicher, Deepak Venkateshvaran, and Christian B. Nielsen
Subjects: Conductive polymer, Electron mobility, Materials science, Physics and Astronomy (miscellaneous), Dopant, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Thermoelectric materials, 01 natural sciences, 7. Clean energy, Engineering physics, 0104 chemical sciences, Condensed Matter::Materials Science, Thermoelectric generator, Condensed Matter::Superconductivity, Seebeck coefficient, Thermoelectric effect, Condensed Matter::Strongly Correlated Electrons, General Materials Science, Charge carrier, 0210 nano-technology, Energy (miscellaneous)
Abstract: Thermoelectric effect is a physical phenomenon which intricately relates the thermal energy of charge carriers to their charge transport. Understanding the mechanism of this interaction in different systems lies at the heart of inventing novel materials which can revolutionize thermoelectric power generation technology. Despite the recent surge of interest in organic thermoelectric materials, the community has had difficulties in formulating the charge transport mechanism in the presence of a significant degree of disorder. Here, we analyze the thermoelectric properties of various conducting polymers doped by solid-state diffusion of dopant molecules based on a transport model with a power law energy dependence of transport function. A fine control of the degree of doping via postdoping annealing provides an accurate empirical evidence of a strong energy dependence of the carrier mobility in the conducting polymers. A superior thermoelectric power factor of conducting polymers doped by solid-state diffusion to that of other doping methods can be attributed to a resulting higher intrinsic mobility and higher free carrier concentration.
Published: 2019

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