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The Canadian Sea Ice and Snow Evolution Network (CanSISE) is a climate research network focused on developing and applying state of the art observational data to advance dynamical prediction, projections, and understanding of seasonal snow cover and sea ice in Canada and the circumpolar Arctic. Here, we present an assessment from the CanSISE network on trends in the historical record of snow cover (fraction, water equivalent) and sea ice (area, concentration, type, and thickness) across Canada. We also assess projected changes in snow cover and sea ice likely to occur by mid-century, as simulated by the Coupled Model Intercomparison Project Phase 5 (CMIP5) suite of earth system models. The historical datasets show that the fraction of Canadian land and marine areas covered by snow and ice is decreasing over time, with seasonal and regional variability in the trends consistent with regional differences in surface temperature trends. In particular, summer sea ice cover has decreased significantly across nearly all Canadian marine regions, and the rate of multiyear ice loss in the Beaufort Sea and Canadian Arctic Archipelago has nearly doubled over the last eight years. The multimodel consensus over the 2020–2050 period shows reductions in fall and spring snow cover fraction and sea ice concentration of 5–10 % per decade (or 15–30 % in total), with similar reductions in winter sea ice concentration in both Hudson Bay and eastern Canadian waters. Peak pre-melt terrestrial snow water equivalent reductions of up to 10 % per decade (30 % in total) are projected across southern Canada.

ACL; International audience; We use transmission optical microscopy to observe cyclopentane hydrate growth in sub-mm, open glass capillaries, mimicking cylindrical pores. The capillary is initially loaded with water and the guest fluid (cyclopentane) and thus possesses three menisci, that between water and cyclopentane (CP) in the middle and two menisci with the vapors at the ends. At temperatures T below the equilibrium temperature Teq ≈ 7 °C, the hydrate nucleates on the water-CP meniscus, rapidly coating it with an immobile, polycrystalline crust. Continued movement of the other two menisci provides insights into hydrate growth mechanisms, via the consumption and displacement of the fluids. On water-wet glass, the subsequent growth consists of a hydrate "halo" creeping with an underlying water layer on the glass on the CP side of the meniscus. Symmetrically, on CP-wet glass (silane-treated), a halo and a CP layer grow on the water side of the interface. No halo is observed on intermediate wet glass. The halo consists of an array of large monocrystals, over a thick water layer at low supercooling (ΔT = Teq - T below 5 K), and a finer, polycrystalline texture over a thinner water layer at higher ΔT. Furthermore, the velocity varies as ΔTα, with α ≈ 2.7, making the early stages of growth very similar to gas hydrate crusts growing over water-guest interfaces. Beyond a length in the millimeter range, the halo and its water layer abruptly decelerate and thin down to submicron thickness. The halo passes through the meniscus with the vapor without slowing down or change of texture. A model of the mass balance of the fluids helps rationalize all of these observations. © 2017 American Chemical Society.

This study assesses the ability of the Canadian Seasonal to Interannual Prediction System (CanSIPS) and the Canadian Earth-system Model 2 (CanESM2) to predict and simulate snow and sea ice from seasonal to multi-decadal timescales, with a focus on the Canadian sector. To account for observational uncertainty, model structural uncertainty, and internal climate variability, the analysis uses multi-source observations, multiple Earth-System Models (ESMs) in Phase 5 of the Coupled Model Intercomparison Project (CMIP5) archive, and initial condition ensembles of CanESM2 and other models. It is found that the ability of the CanESM2 simulation to capture snow-related climate parameters, such as cold-region temperature and precipitation, lies within the range of currently available international models. Accounting for the considerable disagreement among satellite-era observational datasets on the distribution of snow water equivalent, CanESM2 has too much springtime snow cover over the Canadian land mass, reflecting a broader Northern Hemisphere positive bias. It also exhibits retreat of springtime snow generally greater than observational estimates, after accounting for observational uncertainty and internal variability. Sea ice is biased low in the Canadian Arctic, which makes it difficult to assess the realism of long-term sea-ice trends there. The strengths and weaknesses of the modeling system need to be understood as a practical tradeoff: the Canadian models are relatively inexpensive computationally because of their moderate resolution, thus enabling their use in operational seasonal prediction and for generating large ensembles of multidecadal simulations. Improvements in climate prediction systems like CanSIPS rely not just on simulation quality but also on using novel observational constraints and the ready transfer of research to an operational setting. Improvements in seasonal forecasting practice arising from recent research include accurate initialization of snow and frozen soil, accounting for observational uncertainty in forecast verification, and sea-ice thickness initialization using statistical predictors available in real time.

OS; International audience; This chapter reviews high‐resolution optical microscopy methods and highlights their value for gas hydrate research with examples addressing a model hydrate system, cyclopentane hydrate. It illustrates the potential and complementarity of various imaging modes including differential interference contrast (DIC), dark field, fluorescence and (confocal) reflection. These modes are readily available in modern, infinity‐corrected optical microscopes. The chapter also illustrates the potential of Brewster angle microscopy for precise imaging of lateral heterogeneities on a planar surface. Based on Brewster angle microscopy observations, the chapter argues that nonuniform (or “patchy”) polymer adsorption is responsible for these two apparently contradictory phenomena — inhibition of gas hydrate formation and enhanced stability of the formed hydrate. The proposed mechanism is similar to that proposed in the literature for explaining both why anti‐freeze proteins (AFPs) stop ice growth at T well below 0 °C and why ice crystals melt at temperatures significantly above 0 °C up to ~0.5 °C.

International audience; A modified Stober method is used to synthesize spherical core-shell silica nanoparticles (NPs) with an external surface functionalized by amino groups and with an average size around 50 nm. Fluorescent dyes and photosensitizers of singlet oxygen were fixed, either separately or conjointly, respectively in the core or in the shell. Rhodamines were encapsulated in the core with relatively high fluorescence quantum yields (Φfl ≥ 0.3), allowing fluorescence tracking of the particles. Various photosensitizers of singlet oxygen (PS) were covalenty coupled to the shell, allowing singlet oxygen production. The stability of NP suspensions strongly deteriorated upon grafting the PS, affecting their apparent singlet oxygen quantum yields. Agglomeration of NPs depends both on the type and on the amount of grafted photosensitizer. New, lab-made, halogenated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPY) grafted to the NPs achieved higher singlet oxygen quantum yields (ΦΔ ∼ 0.35-0.40) than Rose Bengal (RB) grafted NPs (ΦΔ ∼ 0.10-0.27). Finally, we combined both fluorescence and PS functions in the same NP, namely a rhodamine in the silica core and a BODIPY or RB grafted in the shell, achieving the performance Φfl ∼ 0.10-0.20, ΦΔ ∼ 0.16-0.25 with a single excitation wavelength. Thus, proper choice of the dyes, of their concentrations inside and on the NPs and the grafting method enables fine-tuning of singlet oxygen production and fluorescence emission.[on SciFinder (R)]

Multiple myeloma (MM) is a haematological malignancy characterised by the clonal proliferation of plasma cells in the bone marrow. More than 80% of patients with MM display evidence of myeloma bone disease (MBD), characterised by the formation of osteolytic lesions throughout the axial and appendicular skeleton. MBD significantly increases the risk of skeletal-related events such as pathologic fracture, spinal cord compression and hypercalcaemia. MBD is the result of MM plasma cells-mediated activation of osteoclast activity and suppression of osteoblast activity. Bisphosphonates (BP), pyrophosphate analogues with high bone affinity, are the only pharmacological agents currently recommended for the treatment and prevention of MBD and remain the standard of care. Pamidronate and zoledronic acid are the most commonly used BP to treat MBD. Although generally safe, frequent high doses of BP are associated with adverse events such as renal toxicity and osteonecrosis of the jaw. As such, optimal duration and dosing of BP therapy is required in order to minimise BP-associated adverse events. The following guidelines provide currently available evidence for the adoption of a tailored approach when using BP for the management of MBD.

Diclofenac is one of the most widely prescribed nonsteroidal anti-inflammatory drugs worldwide. It is frequently detected in surface waters; however, whether this pharmaceutical poses a risk to aquatic organisms is debated. Here we quantified the uptake of diclofenac by the fathead minnow (Pimephales promelas) following aqueous exposure (0.2-25.0 μg L

Promoting high growth firms (HGFs) has become a strong fixation within enterprise policy. This is a debate article seeking to examine and challenge the mythology perpetuated by policy makers and embedded within high growth entrepreneurship policy frameworks. Within the article we argue that a number of distinctive ‘myths’ have become deeply embedded within these policy frameworks. Such myths have been built on misconceived preconceptions of HGFs, which has resulted in policy-makers taking a myopic view of these firms. A key aim of the paper is to highlight how false perceptions of HGFs translate into inappropriate policy interventions. The paper challenges some of the most commonly held myths about these firms (that they are predominantly young, small, high-tech, VC-backed, university spin-outs, who grow in an orderly organic fashion, operating similarly irrespective of location) and identifies a clear mismatch between how policy makers perceive HGFs and what they actually look like in reality. Suggestions for the design of future policy approaches are forwarded. Postprint

This paper examines the dynamics of entrepreneurial acquisitions undertaken by UK high growth small and medium enterprises (SMEs). While entrepreneurial acquisitions are increasingly deployed by SMEs, little is known about their antecedents, motivational drivers and organisational outcomes. Drawing on detailed case study evidence from Scotland, the key factor found to be driving these acquisitions was the desire to augment and exploit technological complementarities between the acquiring and acquired firms. Acquisition can therefore be conceptualised as an advanced stage of the outside-in ‘open innovation’ strategies proactively used within these innovative SMEs. Firms executing this strategy typically have an acute propensity for risk, a desire for close customer engagement, effective business models and strong external orientation. The work suggests that greater attention should be paid within M&A theory to the dynamics of these kind of smaller scale entrepreneurial acquisitions. Postprint

International audience; Round glass capillaries are a basic tool in soft-matter science, but often are shunned due to the astigmatism they introduce in micrographs. Here, we show how refraction in a capillary can be a help instead of a hindrance to obtain precise and sensitive information on two important interfacial properties: the contact angle of two immiscible fluids and the presence of thin films on the capillary wall. Understanding optical cusps due to refraction allows direct mesurement of the inner diameter of a capillary at the meniscus, which, with the height of the meniscus cap, determines the contact angle. The meniscus can thus be measured without intrusive additives to enhance visibility, such as dyes or calibrated particles, in uniform, curved, or even tapered capillaries or under demanding conditions not accessible by conventional methods, such as small volumes (μL), high temperatures, or high pressures. We further elicit the conditions for strong internal reflection on the inner capillary wall, involving the wall and fluid refractive indices and the wall thickness, and show how to choose the capillary section to detect thin (submicron) layers on the wall, by the contribution of total internal reflection to the cusps. As examples, we report the following: (i) CO2-water or -brine contact angles at glass interfaces, measured at temperatures and pressures up to 200 °C and 600 bar, revealing an effect apparently so far unreported-the decrease in the water-wet character of glass, due to dissolved salts in brine, is strongly reduced at high temperatures, where contact angles converge toward the values in pure water; (ii) A tenuous gas hydrate layer growing from the water-guest contact line on glass, invisible in transmission microscopy but prominent in the cusps due to total internal reflection.[on SciFinder (R)]

Eliciting accurate and complete knowledge from individuals is a non-trivial challenge. In this paper, we present the evaluation of a virtual-world based approach, informed by situated cognition theory, which aims to assist with knowledge elicitation. In this approach, we place users into 3D virtual worlds which represent real-world locations and ask users to describe information related to tasks completed in those locations. Through an empirical A/B evaluation of 62 users, we explore the differences in recall ability and behaviour of those viewing the virtual world via a virtual reality headset and those viewing the virtual world on a monitor. Previous results suggest that the use of a virtual reality headset was able to meaningfully improve memory recall ability within the given scenario. In this study, we adjust experiment protocol to explore the potential confounds of time taken and tool usability. After controlling for these possible confounds, we once again found that those given a virtual reality headset were able to recall more information about the given task than those viewing the virtual world on a monitor.

Promoting new technology-based firms is the cornerstone of technology entrepreneurship policies in advanced industrial economies. Drawing on quantitative and qualitative empirical evidence from the UK, this paper provides a critique of these policy frameworks. The aggregate analysis shows that vast majority of these firms are micro firms, a small minority of whom grow rapidly. The paper then highlights the incongruence between the nature of these firms and the public sector technology policies designed to support them. The qualitative data reveals that typically these firms are corporate rather than university spin-offs; most do not undertake large amounts of in-house RD most do not have protected IP; and only a small minority are VC-backed. Most derive their main competitive advantages from open innovation sources such as relationships with end-users and customers. The paper offers suggestions for how policy could be recalibrated to better reflect the requirements of local entrepreneurial actors and the types of support required by most high-tech SMEs.

Ouranos is a nonprofit consortium launched in 2002 with the mandate to provide climate services to its governmental, academic, and private partners. These services have focused on the impacts of climate change in the province of Quebec, the identification of vulnerabilities and opportunities associated with the future climate, and the assessment of adaptation options. This paper discusses the experience and insights acquired at Ouranos over the last 10 years in building climate scenarios in support of these impact and adaptation studies. Most of this work is aimed at making climate science intelligible and useful for end users, and the paper describes approaches to developing climate scenarios that are tailored to the needs and level of climate expertise of different user categories. The experience has shown that a group of professionals dedicated to scenario construction and user support is a key element in the delivery of effective climate services.

Snow cover simulations from versions 2.7 and 3.5 of the Canadian Land Surface Scheme (CLASS) coupled to the Canadian Regional Climate Model, version 4 (CRCM4), are evaluated over northern Québec and the larger Québec domain using in situ and remotely sensed datasets. Version 2.7 of CLASS has been used in the operational version of CRCM4 at Ouranos since 2006. Version 3.5 includes a number of improvements to the snow processes as well as a more realistic parameterization of snow thermal conductivity. The evaluation shows that version 3.5 provides improved simulations of snow water equivalent, density, depth, and snowpack temperature values. However, snowpack density still contains systematic biases during the snow season that need to be addressed. The snow albedo parameterization in CLASS was found to be very sensitive to an empirical snowfall rate threshold for albedo refreshment and does not keep track of the snow accumulation history in estimating the snow surface albedo. A modified albedo scheme based on snow-specific surface areas is proposed to address this problem.

This study evaluates key aspects of the snow cover, cloud cover, and radiation budget simulated by the Canadian Regional Climate Model, version 4 (CRCM4), coupled with two versions of the Canadian Land Surface Scheme (CLASS). CRCM4 coupled with CLASS version 2.7 has been used operationally at Ouranos since 2006, while, more recently, CRCM4 has been coupled experimentally with CLASS 3.5, which includes a number of improvements to the representation of snow cover processes. The simulations showed evidence of a systematic cold temperature bias. Evaluation of cloud cover and radiation fluxes with satellite data suggests this bias is related to insufficient cloud radiative forcing from a combination of underestimated cloud cover, excessive cloud albedo, and too low cloud emissivity in the model. This cold bias is reinforced by a positive snow albedo feedback manifest through earlier snow cover onset in the fall and early winter period. Snow albedo was found to be very sensitive to the treatment of albedo refresh but insignificantly influenced by the partitioning of solid precipitation in CLASS. This study demonstrates that atmospheric forcing can exert a significant impact on the simulation of snow cover and surface albedo. The results highlight the need to evaluate parameterizations in land surface models designed for climate models in fully coupled mode.

Discrepancies in the literature between regulatory T cell (Treg) and pro-inflammatory T helper 17 (Th17) numbers in multiple myeloma (MM) can be largely explained by technical differences in methodology and patient selection. In this study, Treg cells were defined as CD3(+)CD4(+)CD25(++)CD127(lo) cells. Patients with MM (n = 20) had a significant imbalance in Treg/Th17 ratio when compared with either aged-matched controls (n = 28) or other monoclonal gammopathies, and this was associated with a significantly worse survival. The percent Treg in bone marrow of patients with MM was higher than that in matched peripheral blood samples (p = 0.02), although FOXP3 expression within bone marrow T cells was lower (p = 0.02). We observed increased Treg function, both in vivo and in vitro, due at least partially to an increase in CTLA-4 expression by concurrent treatment with dexamethasone and immune modulatory compounds (iMiDs). We suggest that immunoregulatory balance is important during active chemotherapy and that conclusions related to the immunostimulatory effect of iMiDs based on in vitro testing must be considered with caution.

Preliminary historical archaeological research on Lizard Island in far north Queensland is enabling the Queensland Government to develop more effective management strategies for on-site interpretation of the historical precinct of Watsons Bay. Although popularly associated with the north Queensland colonial heroine Mary Watson, the Bay can now be understood as a large multilayered cultural landscape with meaning to a wide variety of groups. The common aspects of the three known beche-de-mer operations that occupied the Bay between 1860 and 1881 and the nature of the emerging archaeological record afford many opportunities for scaled archaeological research. It further highlights aspects of historical archaeological theory and the relationship between the discipline and the historical record.

PurposeAs a means of contributing to the literature surrounding the evolution and growth of firms, this paper seeks to outline the explanatory concept of growth trigger points. It aims to examine the forces that propel firms towards different stages of growth and argues that high‐growth firms (HGFs) often encounter important “trigger points” that can affect their growth capabilities. The paper's main aim is to define, conceptualise and illustrate the role of trigger points in promoting rapid growth within businesses.Design/methodology/approachThe primary methodological approach used was intensive case study research of HGFs in Scotland. The case studies, 40 firms in total, were compiled using a mixed method research approach that included, inter alia, background desk research, firm interviews and interviews with business advisers.FindingsThe research discovered that growth trigger points are extremely diverse and play a major role in shaping the growth trajectory of firms, and highlights three main types of trigger points. While trigger points can fundamentally reconfigure organisations, providing a catalyst for a business to undertake a period of rapid, transformative growth, these events can conversely cause severe organisational turbulence or even decline. Often the critical period determining the ultimate success of the growth opportunity presented is the post‐trigger transition period identified by the authors.Practical implicationsThe paper aims to inform public policy on how to support high‐growth entrepreneurship. From a policy perspective, understanding these trigger points is essential for helping policymakers to prioritise and optimise their interventions to help promote rapid firm growth.Originality/valueThe paper's unique contribution to the literature is to help conceptualise how firms move along a growth trajectory, by introducing the novel concept of growth “trigger points”. The paper also seeks to inform public policy, so that interventions can be better attuned to the requirements of dynamic growth businesses.

[1] A new satellite passive microwave (PMW) melt onset retrieval algorithm based on temporal variations in the differences of the brightness temperature between 19 and 37 GHz is shown to be as effective as radar (e.g., QuikScat) measurements. The PMW technique shows improved melt estimates that are more closely linked to observed snow-off dates than previous studies. An integrated pan-Arctic (north of 50°N) melt onset date (MOD) dataset is produced by combining estimates on land and sea ice for the entire satellite PMW record. During the 1979–2011 period, significant trends of 2~3 days (decade)−1 to earlier MOD are mainly concentrated over the Eurasian land sector of the Arctic, consistent with changes in spring snow cover extent observed with visible satellite data. The variability and change in melt onset are largely driven by spring surface air temperature, with insignificant influence from low-frequency modes of atmospheric circulation.

Business process models have become an effective way of examining business practices to identify areas for improvement. While common information gathering approaches are generally efficacious, they can be quite time consuming and have the risk of developing inaccuracies when information is forgotten or incorrectly interpreted by analysts. In this study, the potential of a role-playing approach to process elicitation and specification has been examined. This method allows stakeholders to enter a virtual world and role-play actions similarly to how they would in reality. As actions are completed, a model is automatically developed, removing the need for stakeholders to learn and understand a modelling grammar. An empirical investigation comparing both the modelling outputs and participant behaviour of this virtual world role-play elicitor with an S-BPM process modelling tool found that while the modelling approaches of the two groups varied greatly, the virtual world elicitor may not only improve both the number of individual process task steps remembered and the correctness of task ordering, but also provide a reduction in the time required for stakeholders to model a process view. HighlightsImplemented a virtual world (VW) role-play tool to assist with process elicitation.Performed A/B experiment comparing developed VW with standard 2D modelling tool.VW group specified more tasks, made fewer errors and took significantly less time.VW group referred to similar actions/objects more consistently with their naming.Behavior of VW participants consistent with identified traits of better modellers.

Understanding the interactions of the immune system and B-cell tumours has great therapeutic potential. Both in myeloma and Waldenstrom’s macroglobulinaemia (WM), there are measurable changes in the immune system with abnormalities of T-cells, NK cells and the ability to respond to external immunological stimuli. The homeostatic balance between the activation and suppression of immune antitumour effector cells in vivo is controlled by a network of cytokines and regulatory cells in a defined micro-environment. In myeloma, malignant plasma cells appear to have multiple mechanisms of inhibiting the antitumour immune response. These include inactivation of clonal cytotoxic T-cell, depression of NK and dendritic cell function and altering the regulatory T and pro-inflammatory Th17 cell balance in favour of a suppressive state. In addition, in myeloma, trogocytosis (demonstrated by malignant membrane transfer to T-cells) of plasma cells by T-lymphocytes results in the development of inhibitory Treg cells. In addition myeloid-derived suppressor cells (MDSC) are numerically increased, localised to the bone marrow micro-environment and functionally more active in patients with myeloma as compared to normal. The state of the immune homeostatic balance in WM has not yet been so clearly defined but results in the development of clonal cytotoxic T-cells, with possible abnormalities in Treg and Th17 populations and defects in NK cell function under active investigation.

The authors wish to thank Scottish Enterprise and the OECD for funding the research reported in this paper. High growth firms are now a major focus within enterprise policy. This paper provides a theoretically informed analysis of the rationale and effectiveness of targeted public sector support designed to support these firms. Drawing on empirical research undertaken in the UK, this paper challenges the appropriateness of the theoretical assumptions embodied in these state-backed support instruments. It outlines the nature of these programmes and provides a critique of some of their inherent weaknesses, revealing that the assumptions underpinning these programmes are often flawed. The paper examines the limitations of their selection procedures, the thematic nature of support and exit dynamics. It found that offering early stage firms intensive levels of resources may have important unintended consequences previously overlooked by policy makers. The paper offers some suggestions for how policy instruments could be better attuned to the needs of these growth-oriented firms. Publisher PDF

Analyzing and redesigning business processes is a complex task which requires the collaboration of multiple actors such as process stakeholders, domain experts and others. Current collaborative modeling approaches mainly focus on modeling workshops where participants verbally contribute their perspective on a process along with ideas on how to improve it. These workshops are supported by modeling experts who facilitate the workshop and translate participants’ verbal contributions into a process model. Being limited to verbal contributions however might negatively affect the motivation of participants to actively contribute. Interactive technology such as smartphones, tablets, digital tabletops and interactive walls can provide opportunities for participants to directly interact with process models. Multi surface environments where different interactive technologies (e.g. display walls, tabletops, tablets, and mobiles) are combined also allow for orchestrating different modes of collaboration. In this chapter we describe an approach that combines different styles of collaboration using various interactive surfaces in a multi surface environment. Testing this approach in three different settings we found indications that interactive technology not only improves involvement by participants but also speeds up workshops and improves the quality of collaboration outcomes. The studies also revealed means for improving the proposed approach.

Waldenström macroglobulinaemia (WM) is an indolent B-cell malignancy characterised by the presence of immunoglobulin M (IgM) paraprotein and bone marrow infiltration by clonal small B lymphocytes, plasmacytoid lymphocytes and plasma cells. The symptoms of WM are protean, often follow an asymptomatic phase and may include complications related to the paraneoplastic effects of IgM paraprotein. The revised 2016 World Health Organization classification includes the MYD88 L265P mutation, which is seen in90% of cases, within the diagnostic criteria for WM. While treatment of WM has often been considered together with other indolent B cell lymphomas, there are unique aspects of WM management that require specific care. These include the unreliability of IgM and paraprotein measurements in monitoring patients prior to and after treatment, the lack of correlation between disease burden and symptoms and rituximab-induced IgM flare. Moreover, while bendamustine and rituximab has recently been approved for reimbursed frontline use in WM in Australia, other regimens, including ibrutinib- and bortezomib-based treatments, are not funded, requiring tailoring of treatment to the regional regulatory environment. The Medical and Scientific Advisory Group of the Myeloma Foundation Australia has therefore developed clinical practice guidelines with specific recommendations for the work-up and therapy of WM to assist Australian clinicians in the management of this disease.

This paper considers geographical variations in the demand and supply of bank finance for innovative firms in the UK. It uses a detailed survey on the finances of almost 40,000 UK Small and Medium Sized Enterprises for 2011–2013 to investigate both the extent and type of applications for bank finance by innovative firms in peripheral regions, whether funders accept their applications and whether acceptance rates reflect objective criteria, such as credit scores, or their location. The paper finds evidence of higher demand for bank finance for innovative firms in peripheral areas, but that these firms are more likely to be discouraged from applying. However, there is strong evidence that innovative firms in peripheral regions are more likely to have their applications for finance rejected, even when controlling for factors such as credit score. The findings suggest that geography matters in the financing of innovative firms and firms in peripheral areas may suffer a “liability of distance” which potentially reinforces regional disparities. The implications of these findings for public policy are outlined. Postprint

The authors wish to thank Scottish Enterprise for funding the research reported in this paper. In recent years there has been an upsurge of interest by policy makers in high growth firms (HGFs). Interest in these dynamic firms has primarily been driven by their prodigious ability to create new employment. Despite this, very little is known about the complex corporate geographies of these firms and their internationalisation processes. Using quantitative and qualitative data, this paper explores this issue by examining Scottish HGFs. HGFs were found to adopt more aggressive forms of international expansion, such as overseas acquisitions, than their non-HGF counterparts. As a result of these complex growth processes, a large proportion of HGF employment growth is generated outside Scotland. The paper concludes that the regional development impact of HGFs for small peripheral economies in the UK is more limited than originally envisaged. The implications of the study for further research and public policy are examined. Publisher PDF

Despite evidence from a number of Earth systems that abrupt temporal changes known as regime shifts are important, their nature, scale and mechanisms remain poorly documented and understood. Applying principal component analysis, change-point analysis and a sequential t-test analysis of regime shifts to 72 time series, we confirm that the 1980s regime shift represented a major change in the Earth's biophysical systems from the upper atmosphere to the depths of the ocean and from the Arctic to the Antarctic, and occurred at slightly different times around the world. Using historical climate model simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5) and statistical modelling of historical temperatures, we then demonstrate that this event was triggered by rapid global warming from anthropogenic plus natural forcing, the latter associated with the recovery from the El Chichón volcanic eruption. The shift in temperature that occurred at this time is hypothesized as the main forcing for a cascade of abrupt environmental changes. Within the context of the last century or more, the 1980s event was unique in terms of its global scope and scale; our observed consequences imply that if unavoidable natural events such as major volcanic eruptions interact with anthropogenic warming unforeseen multiplier effects may occur. published

This critical review examines the definition and implementation of environmental protection goals for chemicals in current European Union (EU) legislation, guidelines, and international agreements to which EU countries are party. The European chemical industry is highly regulated, and prospective environmental risk assessments (ERAs) are tailored for different classes of chemical, according to their specific hazards, uses, and environmental exposure profiles. However, environmental protection goals are often highly generic, requiring the prevention of "unacceptable" or "adverse" impacts on "biodiversity" and "ecosystems" or the "environment as a whole." This review aims to highlight working examples, challenges, solutions, and best practices for defining specific protection goals (SPGs), which are seen to be essential for refining and improving ERA. Specific protection goals hinge on discerning acceptable versus unacceptable adverse effects on the key attributes of relevant, sensitive ecological entities (ranging from organisms to ecosystems). Some isolated examples of SPGs for terrestrial and aquatic biota can be found in prospective ERA guidance for plant protection products (PPPs). However, SPGs are generally limited to environmental or nature legislation that requires environmental monitoring and retrospective ERA. This limitation is due mainly to the availability of baselines, which define acceptable versus unacceptable environmental effects on the key attributes of sentinel species, populations and/or communities, such as reproductive status, abundance, or diversity. Nevertheless, very few regulatory case examples exist in which SPGs incorporate effect magnitude, spatial extent, and temporal duration. We conclude that more holistic approaches are needed for defining SPGs, particularly with respect to protecting population sustainability, ecosystem function, and integrity, which are implicit in generic protection goals and explicit in the International Programme for Chemical Safety (IPCS) definition of "adverse effect." A possible solution, which the chemical industry is currently assessing, is wider application of the ecosystem services approach proposed by the European Food Safety Authority (EFSA) for the risk assessment of PPPs. Integr Environ Assess Manag 2017;13:17-37. © 2016 SETAC.

As part of their “third mission” to commercialise research and cultivate growth in local economies, universities have been accorded a central role in regional innovation systems. This paper takes issue with this policy emphasis. It presents empirical evidence suggesting the entrepreneurial spillovers from universities have been greatly exaggerated, especially in some peripheral regions. The explanation offered for this poor performance hinges on the substantive disconnect between universities and their surrounding local entrepreneurial and innovation ecosystems. Despite their marginal economic contribution, the paper claims that “policy entrepreneurs” play a powerful role in cumulatively reinforcing the dominant role of universities through a process of “institutional capture”, the outcome of which results in a form of “policy lock-in”. The implications of these findings for public policy are outlined. Postprint

The Neuregulin-1 (Nrg1) signaling pathway has been widely implicated in many aspects of heart development including cardiac trabeculation. Cardiac trabeculation is an important morphogenetic process where clusters of ventricular cardiomyocytes extrude and expand into the lumen of the ventricular chambers. In mouse, Nrg1 isoforms containing an immunoglobulin-like (IgG) domain are essential for cardiac trabeculation through interaction with heterodimers of the epidermal growth factor-like (EGF-like) receptors ErbB2/ErbB4. Recent reports have underscored the importance of Nrg1 signaling in cardiac homeostasis and disease, however, placental development has precluded refined evaluation of the role of this pathway in mammals. ErbB2 has been shown to have a developmentally conserved role in cardiac trabeculation in zebrafish, a vertebrate model organism with completely external development, but the requirement for Nrg1 has not been examined. We found that among the multiple Nrg1 isoforms, the IgG domain-containing, type I Nrg1 (nrg1-I) is the only isoform detectable in the heart. Then, using CRISPR/Cas9 gene editing, we targeted the IgG domain of Nrg1 to produce novel alleles, nrg1nc28 and nrg1nc29, encoding nrg1-I and nrg1-II truncations. Our results indicated that zebrafish deficient for nrg1-I developed trabeculae in an ErbB2-dependent manner. Further, these mutants survive to reproductive adulthood with no overt cardiovascular defects. We also found that additional EGF-like ligands were expressed in the zebrafish heart during development of trabeculae. Together, these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF-like ligand(s) activates the ErbB2/ErbB4 pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF family member requirements for an evolutionary conserved process.

Eliciting accurate knowledge from individuals is a non-trivial challenge. In this paper, we present the evaluation of a virtual reality-based approach to knowledge elicitation informed by situated cognition theory. This approach places users into 3D virtual worlds representing real-world locations and asks them to recall information about tasks completed in those locations. Through an empirical A/B evaluation of 64 users, we investigate whether the situated context provided by these virtual environments is adequate to assist with memory recall, and explore whether the added immersion provided by a head-mounted display (HMD) may meaningfully improve user memory recall capability when compared with a desktop display experience. Results suggest that those provided with a HMD may be able to recall more information about a sequenced task than those provided with a desktop display.

International audience; Organic clathrate compounds, particularly those formed between hydroquinone (HQ) and gases, are supramolecular entities recently highlighted as promising alternatives for applications such as gas storage and separation processes. This study provides new insights into CO2–HQ clathrate, which is a key structure in some of the proposed future applications of these compounds. We present a novel synthesis and purification of CO2–HQ clathrate monocrystals. Clathrate crystals obtained from a single synthesis and native HQ are characterized and compared using Raman/Fourier transform infrared/NMR spectroscopies, optical microscopy, and thermogravimetric analysis coupled to mass spectrometry. The molecular structure of the clathrate has been resolved by X-ray diffraction analysis, and detailed crystallographic information is presented for the first time.

International audience; Growth of gas hydrates as fast-growing polycrystalline crusts at interfaces between water and guest phases is well documented, but the mechanisms of hydrate growth on solid substrates are much less known. We report here on cyclopentane (CP) hydrate spreading on glass (fused silica) under CP. As seen for methane hydrate by Beltrán and Servio (Cryst. Growth Des. 2010, 10, 4339-4347), CP hydrate grows on glass as a "halo" radiating from the contact line of a "primary" drop. Complementary optical microscopies at micron resolution here allow identification of the mechanisms of halo growth and melting. We conclude that forms of water on the substrate control halo spreading, namely, a precursor film near the contact line and a breath figure (dew) condensed from the CP (halo spreading at ≤2 μm s-1 at T 0 °C or subcooling ∼7 °C), and "leap-frogging" (at ∼10 μm s-1) over "secondary" drops left behind by melting a previous halo. Halo thickening, about 5 nm s-1, is attributed to water condensation, either incorporation of water dissolved in CP (like ablimation) or settling of water "fog" from the CP. Halos spread slower on untreated, compared to hydrophilic, glass, an effect attributed to the quantity of water present on the substrate; a similar trend is noted when the CP phase is not pre-equilibrated with water prior to the experiment. No hydrate halo was detected on hydrophobized (silane-treated) glass, where the breath figure is absent.

The increasingly widespread use of large-scale 3D virtual environments has translated into an increasing effort required from designers, developers and testers. While considerable research has been conducted into assisting the design of virtual world content and mechanics, to date, only limited contributions have been made regarding the automatic testing of the underpinning graphics software and hardware. In the work presented in this paper, two novel neural network-based approaches are presented to predict the correct visualization of 3D content. Multilayer perceptrons and self-organizing maps are trained to learn the normal geometric and color appearance of objects from validated frames and then used to detect novel or anomalous renderings in new images. Our approach is general, for the appearance of the object is learned rather than explicitly represented. Experiments were conducted on a game engine to determine the applicability and effectiveness of our algorithms. The results show that the neural network technology can be effectively used to address the problem of automatic and reliable visual testing of 3D virtual environments.

High growth firms play a disproportionate role in contributing to the economic vitality of regional economies. These are precisely the types of businesses that policy makers need to support in order to generate economic growth. Despite this, the article argues that current regional industrial and enterprise promotion policies in the UK are poorly equipped to help firms grow rapidly. This argument is developed by means of a critical examination of innovation support policies in Scotland. Indeed, many governments use such policies as a surrogate form of high growth firm policy. The article discusses the underlying principles and types of support which are needed to help foster and support rapidly growing firms. It argues that effective policy needs to be targeted, selective and customized to the specialist needs of high growth firms. The implementation of these types of policies is best delivered at a sub-national or regional level.

Supercritical water was analyzed recently as a gas of small clusters of waters linked to each other by intermolecular hydrogen-bonds, but unexpected “linear” conformations of clusters are required to reproduce the infra-red (IR) spectra of the supercritical state. Aiming at a better understanding of clusters in supercritical water, this work presents a strategy combining classical molecular dynamics to explore the potential energy landscape of water clusters with quantum mechanical calculation of their IR spectra. For this purpose, we have developed an accurate and flexible force field of water based on the TIP5P 5-site model. Water dimers and trimers obtained with this improved force field compare well with the quantum mechanically optimized clusters. Exploration by simulated annealing of the potential energy surface of the classical force field reveals a new trimer conformation whose IR response determined from quantum calculations could play a role in the IR spectra of supercritical water. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011

Droughts are among the world's most costly natural disasters and collectively affect more people than any other form of natural disaster. The Canadian Prairies are very susceptible to drought and have experienced this phenomenon many times. However, the recent 1999–2005 Prairie drought was one of the worst meteorological, agricultural and hydrologic droughts over the instrumental record. It also had major socio-economic consequences, adding up to losses in the billions of dollars. This recent drought was the focus of the Drought Research Initiative (DRI), the first integrated network focusing on drought in Canada. This article addresses some of the key objectives of DRI by providing a collective summary, understanding and synthesis of the 1999–2005 drought. Bringing together the many datasets used in this study was in itself a major accomplishment. This drought exhibited many important, and sometimes surprising, features. This includes, for example, (1) a non-steady large-scale atmospheric circulation (an...

Writing in Small Business Economics Scott Shane argues that policy-makers should stop subsidising start-ups and instead focus on supporting the small subset of new businesses with high growth potential. However, both Shane and other scholars who have made the same argument only offer broad-brush proposals to achieve this objective. The aim of this article, in contrast, is to engage in a detailed discussion of how to create appropriate policies for high-growth firms (HGFs). Drawing on research in Scotland, we argue that policy-makers are looking for HGFs in the wrong places. The heterogeneous nature of HGFs in terms of sector, age, size and origins makes in impractical to target support on particular sectors, technologies or types of firms (e.g., new or R&D intensive). The article proposes a reorientation of HGFs, both in terms of appropriate targeting and forms of support. Public policy also needs to focus on the retention of HGFs which are acquired by non-local businesses. Finally, policy-makers need to properly reflect upon the specificities of their entrepreneurial environment when devising appropriate policy interventions.

An update is provided of Northern Hemisphere (NH) spring (March, April) snow cover extent (SCE) over the 1922–2010 period incorporating the new climate data record (CDR) version of the NOAA weekly SCE dataset, with annual 95% confidence intervals estimates from regression analysis and intercomparison of multiple datasets. The uncertainty analysis indicated a 95% confidence interval in NH spring SCE of ±5–10% over the pre-satellite period and ±3–5% over the satellite era. The multi-dataset analysis showed there are larger uncertainties monitoring spring SCE over Eurasia (EUR) than North America (NA) due to the more complex regional character of the snow cover variability with the largest dataset uncertainty located over eastern Eurasia in a large region extending from the Tibetan Plateau across northern China. Trend analysis of the updated SCE series provided evidence that NH spring snow cover extent has undergone significant reductions over the past ~90 years and that the rate of decrease has accelerated over the past 40 years. The rate of decrease in March and April NH SCE over the 1970–2010 period is ~7–8 million km2 per 100 years which corresponds to an 8–11% decrease in NH March and April SCE respectively from pre-1970 values. In March, most of the change is being driven by Eurasia (NA trends are not significant) but both continents exhibit significant SCE reductions in April. The observed trends in SCE are consistent with recent warming trends over northern mid-latitude land areas with NH SCE exhibiting significant negative correlations to air temperature anomalies in March and April. The NH spring SCE-temperature sensitivity has remained relatively stable over the period of record although there is some evidence of contrasting changes in temperature sensitivity over both continents in April. There is evidence that changes in atmospheric circulation around 1980 involving the North Atlantic Oscillation and Scandinavian Pattern have contributed to reductions in March SCE over Eurasia.

Mladen Ovadija. Dramaturgy of Sound in the Avant-Garde and Postdramatic Theatre. Montreal: McGill-Queen's University Press, 2013. Pp. x + 252. $95.00. Dramaturgy of Sound in the Avant-Garde and Postdramatic Theatre is published amid an "interdisciplinary ferment in the human sciences that takes sound as its analytical point of departure or arrival" (as Jonathan Sterne, one of the leading figures of Sound Studies, has called the recent surge of interest in sound, noise, auditory culture, and associated histories). Longstanding sound scholars such as this reviewer, once accustomed to interjecting as disciplinary mavericks from the fringes of our arts, social science, and humanities discourse, must now be more cautious about claims that modernity is characterized by a visual bias--an ocularcentrism as Jay has termed it, or a hypertrophy of the eye and "eye-thinking" as Berendt more figuratively put it. It has been suggested that a new postmodern aural paradigm is discernible in the tropes of resonance, rhizomatic networks, fields, ecosystems, and noise that litter contemporary intellectual discourse, particularly in the cultural fetishization of "immersive experience." There is talk of a new age of aurality--a term whose sudden, prolific adoption precedes any clearly established definition, but which seems to indicate a field of interaction between the acoustic world, its inhabitants, and their cultural activities. This may be premature. Theater, whose remit it has been to think through the modern condition by staging it, is in its institutions of practice and scholarship only now starting to conceive of sound as anything other than a technical practice (of acoustics, voice, effect production, or amplification) or a specialist meta-discourse. The consideration of sound in more ontological terms takes it into modally alien territory. While dramas conceptual subservience to the word may have been broken, theater studies has tended to approach sensual materiality though phenomenological tropes of spectatorship and kinesthetic object-theater, or through biomechanically or viscerally physical performance, rather than through audience, aural bodies, and their space. If theater once enquired about visuality and physicality, it now seems to ask about immersion and resonance, about what atmosphere and noise mean when they are no longer in the background, and about the energized materiality between theater's objects. So attention turns to the Sound Studies ferment for a conceptual framework with which to make sense of theaters under-theorized aurality. Ovadija's interest here is primarily in how sonic meaning might be achieved independently of the semiology of words or other indexically "read" sign-systems--how, as he quotes Steve McAfferty, sound "need not be a this standing for that but immediately be a that ... free of the implications of the metaphysics of linguistic absence" (56). The book identifies this enquiry in the works and manifestos of twentieth century avant-garde art and Lehmann's concept (broadly interpreted) of "postdramatic" theater. The book mainly focuses on Dada, Futurism, Expressionism, and the Bauhaus as they appear "through the rear view mirror" (8) of this postdramatic theater. This conceit initially struck me as a crafty way of making a genealogical connection between theater's current interest in sound and some iconic sonic art that (so I had thought) had little to do with theater history, other than in that theaters were occasionally used for its poetry performances or noise concerts. The book makes big claims about the seminality of these movements: that Marinetti, Russolo, and their cohorts liberated the material performativity of sound and noise from its subservience to semantic systems and musical morphology; and that because of this breakthrough, today's theater aurality became possible. In my view this is unnecessarily overstated. It would have been enough simply to use his rear-view mirror conceit to present his new take on the avant-garde experiments with sonic performativity, and allow it to resonate in his accounts of recent developments in theater sound. …

BACKGROUND:: Trauma is a leading cause of morbidity, potential years of life lost and health care expenditure in Canada and around the world. Trauma systems have been established across North America to provide comprehensive injury care and to lead injury control efforts. We sought to describe the current status of trauma systems in Canada and Canadians' access to acute, multidisciplinary trauma care. METHODS:: A national survey was used to identify the locations and capabilities of adult trauma centers across Canada and to identify the catchment populations they serve. Geographic information science methods were used to map the locations of Level I and Level II trauma centers and to define 1-hour road travel times around each trauma center. Data from the 2006 Canadian Census were used to estimate populations within and outside 1-hour access to definitive trauma care. RESULTS:: In Canada, 32 Level I and Level II trauma centers provide definitive trauma care and coordinate the efforts of their surrounding trauma systems. Most Canadians (77.5%) reside within 1-hour road travel catchments of Level I or Level II centers. However, marked geographic disparities in access persist. Of the 22.5% of Canadians who live more than an hour away from a Level I or Level II trauma centers, all are in rural and remote regions. DISCUSSION:: Access to high quality acute trauma care is well established across parts of Canada but a clear urban/rural divide persists. Regional efforts to improve short- and long-term outcomes after severe trauma should focus on the optimization of access to pre-hospital care and acute trauma care in rural communities using locally relevant strategies or novel care delivery options. Language: en

This paper provides an updated fresh snowfall water equivalent adjustment factor (ρswe) map for Canada to allow the estimation of solid precipitation amount from ruler measurements of the depth of freshly fallen snow, which has been the standard method for measuring snowfall since Canadian climate measurements began in the middle of the nineteenth century. The ρswe map is created based on the comparison of corrected solid Nipher gauge precipitation to snowfall ruler depth measurements at 175 stations with more than 20 years of concurrent observations. The Nipher gauge correction process involved a careful analysis of station metadata to obtain precise information on anemometer heights and the dates that Nipher gauges were activated. The updated fresh snowfall water equivalent adjustment factor map allows estimates of ρswe to be obtained for all long‐term climate stations in Canada. The spatial pattern is consistent with processes influencing the density of fresh snowfall and its initial settling ...

International audience; Granular activated carbon (GAC) and more recently activated carbon fibers (ACF) are used for the treatment of volatile organic compounds (VOC) in industrial processes. The purpose of this study was to investigate the adsorption kinetics of ACF to eliminate VOC from polluted air. This approach is carried out by modeling experimental breakthrough curves with two kinds of models: an equilibrium model and a mass transfer model based on a linear driving force (LDF) in conjunction with the Langmuir equilibrium model. The results show the influence of the intraparticle diffusion on the adsorption kinetics of ACF, in spite of their small fiber diameter. Moreover, external diffusion kinetics is fast because of the influence of the large external surface area of ACF on the VOC mass transfer.

Exposure to environmental chemicals can have negative consequences for wildlife and even cause localized population extinctions. Resistance to chemical stress, however, can evolve and the mechanisms include desensitized target sites, reduced chemical uptake and increased metabolic detoxification and sequestration. Chemical resistance in wildlife populations can also arise independently of exposure and may be spread by gene flow between populations. Inbreeding—matings between closely related individuals—can have negative fitness consequences for natural populations, and there is evidence of inbreeding depression in many wildlife populations. In some cases, reduced fitness in inbred populations has been shown to be exacerbated under chemical stress. In chemical testing, both inbred and outbred laboratory animals are used and for human safety assessments, iso-genic strains (virtual clones) of mice and rats are often employed that reduce response variation, the number of animals used and associated costs. In contrast, for environmental risk assessment, strains of animals are often used that have been selectively bred to maintain heterozygosity, with the assumption that they are better able to predict adverse effects in wild, genetically variable, animals. This may not necessarily be the case however, as one outbred strain may not be representative of another or of a wild population. In this paper, we critically discuss relationships between genetic variation, inbreeding and chemical effects with the intention of seeking to support more effective chemical testing for the protection of wildlife.

Economic development agencies worldwide have eagerly embraced clusters as a strategy to boost local economic development. When implementing cluster-based interventions, one of the main issues encountered by many public sector bodies is that the majority of cluster analysis and measurement techniques only give a partial overview of how they actually operate. Often it is the dynamics of collaboration within a cluster that has the biggest influence on overall success. This paper adopts a system thinking approach to help us understand cluster development and inter-firm collaboration. The outcome of this work was the development of a basic five stage conceptual model that helps explain how a cluster develops, together with the changes in company behaviour and company interaction that might be seen at different stages of this developmental trajectory. Using Scotland as an empirical test case, this article highlights the model and examines the problems associated with the adoption of this approach. This methodological approach was shared with other regions working to support clusters to ascertain the relevance of this approach elsewhere. Overall this paper concludes that the model proves to be a useful tool in assessing the varying stages of a cluster's development both within and outside Scotland.

The majority of the world's citizens now live in cities. Although urban planning can thus be thought of as a field with significant ramifications on the human condition, many practitioners feel that it has reached the crossroads in thought leadership between traditional practice and a new, more participatory and open approach. Conventional ways to engage people in participatory planning exercises are limited in reach and scope. At the same time, socio-cultural trends and technology innovation offer opportunities to re-think the status quo in urban planning. NeoGeography introduces tools and services that allow non-geographers to use advanced geographical information systems. Similarly, is there a potential for the emergence of a neo-planning paradigm in which urban planning is carried out through active civic engagement aided by Web 2.0 and new media technologies thus redefining the role of practicing planners? This paper traces a number of evolving links between urban planning, NeoGeography and information and communication technology. Two significant trends-participation and visualisation-with direct implications for urban planning are discussed. Combining advanced participation and visualisation features, the popular virtual reality environment Second Life is then introduced as a test bed to explore a planning workshop and an integrated software event framework to assist narrative generation. We discuss an approach to harness and analyse narratives using virtual reality logging to make transparent how users understand and interpret proposed urban designs.

Atherton (2006) has noted that the current policy preoccupation with increasing start-up levels has been justified in terms of the ‘creative destruction’ it is expected to bring about. However, this article shows that the most commonly employed measures of start-up, and the most common dataset on which they are employed, are inadequate for assessing start-up policy justified in these terms. A new dataset and method is introduced that is better able to uncover creative destruction taking place in the business stock.