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Introduction: Innovative motor therapies have attempted to reduce upper extremity impairment after stroke but have not made substantial improvement as over 50% of people post-stroke continue to have sensorimotor deficits affecting their self-care and participation in daily activities. Intervention studies have focused on the role of increased dosing, however recent studies have indicated that timing of rehabilitation interventions may be as important as dosing and importantly, that dosing and timing interact in mediating effectiveness. This study is designed to empirically test dosing and timing.Methods and Analysis: In this single-blinded, interventional study, subjects will be stratified on two dimensions, impairment level (Fugl-Meyer Upper Extremity Assessment (FM) and presence or absence of Motor Evoked Potentials (MEPs) as follows; (1) Severe, FM score 10–19, MEP+, (2) Severe, FM score 10–19, MEP–, (3) Moderate, FM score 20–49, MEP+, (4) Moderate, FM score 20–49, MEP–. Subjects not eligible for TMS will be assigned to either group 2 (if severe) or group 3 (if moderate). Stratified block randomization will then be used to achieve a balanced assignment. Early Robotic/VR Therapy (EVR) experimental group will receive in-patient usual care therapy plus an extra 10 h of intensive upper extremity therapy focusing on the hand using robotically facilitated rehabilitation interventions presented in virtual environments and initiated 5–30 days post-stroke. Delayed Robotic/VR Therapy (DVR) experimental group will receive the same intervention but initiated 30–60 days post-stroke. Dose-matched usual care group (DMUC) will receive an extra 10 h of usual care initiated 5–30 days post-stroke. Usual Care Group (UC) will receive the usual amount of physical/occupational therapy.Outcomes: There are clinical, neurophysiological, and kinematic/kinetic measures, plus measures of daily arm use and quality of life. Primary outcome is the Action Research Arm Test (ARAT) measured at 4 months post-stroke.Discussion: Outcome measures will be assessed to determine whether there is an early time period in which rehabilitation will be most effective, and whether there is a difference in the recapture of premorbid patterns of movement vs. the development of an efficient, but compensatory movement strategy.Ethical Considerations: The IRBs of New Jersey Institute of Technology, Rutgers University, Northeastern University, and Kessler Foundation reviewed and approved all study protocols. Study was registered in https://ClinicalTrials.gov (NCT03569059) prior to recruitment. Dissemination will include submission to peer-reviewed journals and professional presentations.

Tracheal agenesis – failure of trachea development - is an extremely rare and severe congenital disorder involving the respiratory system and in most cases it is associated with other abnormalities. Three anatomic types of tracheal agenesis were described by Floyd. Antenatal diagnosis is difficult, especially if it is combined with a tracheo-oesophageal fistula. We report a postnatally diagnosed case of a female newborn with Type II tracheal agenesis. Polyhydramnios and right upper limb anomaly were diagnosed prenatally. Only typical postnatal clinical signs, such as severe asphyxia with strong respiratory efforts, no audible cry, failed endotracheal intubation and no palpable tracheal tissue on the neck aroused suspicion of tracheal agenesis. Despite the few published cases when antenatal diagnosis of tracheal agenesis and series of heroic postnatal surgical interventions resulted in few years’ survival, tracheal agenesis is still considered as a lethal condition. Possibilities of antenatal diagnosis, postnatal management and therapeutic options are discussed.

A patient at risk of harboring prostate cancer with a history of ulcerative colitis surgically managed with total colectomy (including the distal rectum and anal canal) underwent CT-planned transperineal prostate biopsy with fluoroscopic guidance. We describe the planning and intraoperative technique to obtain prostate biopsy cores.

Wastes from titanium-magnesium production are characterized by a variety of composition, properties and a wide range of applications. As a result of the research on industrial effluents utilization in titanium-magnesium production a technology was proposed that includes the separation of effluents by centrifugation into liquid and solid parts and the demineralization of the liquid part using vacuum evaporation. As a result of laboratory studies, the optimal composition of the building mixture was determined, which can be used to prepare new materials for the construction industry with high strength characteristics. Optimal cement-sand ratio in the charge of building mixture is 1:3, water-cement ratio is 0.4, thickened pulp of industrial wastes contains 100 -240 g/dm3 of solid part.

The aim of the present study was to investigate whether EEG resting state connectivity correlates with intelligence. One-hundred and sixty five participants took part in the study. Six minutes of eyes closed EEG resting state was recorded for each participant. Graph theoretical connectivity metrics were calculated separately for two well-established synchronization measures [weighted Phase Lag Index (wPLI) and Imaginary Coherence (iMCOH)] and for sensor- and source EEG space. Non-verbal intelligence was measured with Raven’s Progressive Matrices. In line with the Neural Efficiency Hypothesis, path lengths characteristics of the brain networks (Average and Characteristic Path lengths, Diameter and Closeness Centrality) within alpha band range were significantly correlated with non-verbal intelligence for sensor space but no for source space. According to our results, variance in non-verbal intelligence measure can be mainly explained by the graph metrics built from the networks that include both weak and strong connections between the nodes.

Specialization is a program optimization approach that implies the use of a priori information about values of some variables. Specialization methods are being developed since 1970s (mixed computations, partial evaluation, supercompilation). However, it is surprising, that even after three decades, these promising methods have not been put into the wide programming practice. One may wonder: What is the reason? Our hypothesis is that the task of specialization requires much greater human involvement into the specialization process, the analysis of its results and conducting computer experiments than in the case of common program optimization in compilers. Hence, specializers should be embedded into integrated development environments (IDE) familiar to programmers and appropriate interactive tools should be developed. In this paper we provide a work-in-progress report on results of development of an interactive specializer based on partial evaluation for a subset of the Java programming language. The specializer has been implemented within the popular Eclipse IDE. Scenarios of the human-machine dialogue with the specializer and interactive tools to compose the specialization task and to control the process of specialization are under development. An example of application of the current version of the specializer is shown. The residual program runs several times faster than the source one.

Under natural conditions, biodegradation processes proceed slowly, especially in regions with low temperature. To activate vital processes in hydrocarbon-oxidizing microorganisms at low temperatures, biologically active compounds can be employed as growth stimulants. A low-temperature (10 °C) study has shown that tris-(2 hydroxyethyl) ammonium arylchalcogenylacetates, “protatranes” exert an effect on the growth of hydrocarbon-oxidizing strains of Rhodococcus erythropolis and Pseudomonas fluorescens, isolated from natural oil seepage on Lake Baikal. It has been found that “protatranes”, at microconcentrations, increase the growth rate of R. erythropolis bacteria by 2–16 times. It has been established that compounds slightly effect the growth of P. fluorescens. The positive effect of “protatranes” compounds on the growth rate of hydrocarbon-oxidizing microorganisms at low positive temperatures can be used for the development of environmentally benign methods for the restoration of natural objects after their contamination with oil. Keywords: Protatranes, Stimulants, Hydrocarbon-oxidizing bacteria, Lake Baikal, Arylchalcogenylacetic acids, Tris(2-hydroxyethyl)ammonium salts

Background. To assess the structure of inter-ethnic attitudes and the risks of ethnoreligious tension, psychologists mostly use questionnaires, interviews, subjective scaling, content analysis, and special tests. One possible approach to increasing the validity and reliability of these explicit methods is the use of the registration of psychophysiological indicators while a recipient completes the questionnaire or test forms. Objective. The results of a pilot psychophysiological research are presented, which focus on the study of human psycho-emotional states during socio-psychological testing to identify attitudes in the field of interethnic and interfaith relations. Design. The essence of the applied experimental approach is to control the functional (psycho-emotional) state of a respondent using the registration of complex psychophysiological (physiological and behavioral) responses in the process of completing the socio-psychological questionnaire. Results. It was shown that the rhythmic brain activity (ratio of the power indexes of alpha and beta rhythms), the amplitude of the systolic wave (photoplethysmogram) (ASW PhPG) and the magnitude (length) of the ‘circumflex line of the Galvanic Skin Response’ (GSR-L) may be the complex of indicators that possess sufficiently high selective sensitivity to differentiate nonspecific reactions of the human nervous system to personally important (emotiogenic, stressful) questions in the questionnaire. Conclusion. The proposed approach may help to identify stressful (emotiogenic) issues (questions) in socio-psychological tests and questionnaires that are of the greatest interest to the subject and, as a result, most adequately reflect individual and population attitudes in the field of social relations.

Naroch lakes present a system of three interconnected water bodies of different trophic state, many years monitoring of which allowed to establish and reveal a number of fundamental patterns of functioning of aquatic ecosystems. Over the past 60 years, several stages in the evolution of the structure and functional organization of the ecosystem are clearly traced. Within the framework of the work the following periods were considered: 1) anthropogenic eutrophication (1978-1983); 2) oligotrophication (from 1984 to 1990 for Lake Naroch and from 1984 to 1990 for Lakes Myastro and Batorino) and 3) the period of bentification (since 1991 for Lake Naroch and since 1990 for Lakes Myastro and Batorino to the present). The values of the most part of parameters that are taken into account when assessing the trophic state of ecosystems (phosphorus, chlorophyll, phytoplankton, seston) are significantly reduced at bentification period compared to that of anthropogenic eutrophication. In the same time gross primary production of plankton in Lake Naroch actually did not change. One of the important reasons for this may be an increase in the depth of trophogenic layer and as a result an increase in its volume in regard to the entire volume of the lake. Production of submerged and emergent macrophytes in Lake Naroch during the period of bentification increased in 2 and 4 times respectively, compared with the period of eutrophication. The level of production of periphyton communities has not changed significantly. Based on the dynamics of the main hydroecological parameters of the Naroch lakes in different periods of their evolution, the uncertainty in assessing such a key characteristic of the ecosystem as its trophic state is evident, which can differ significantly depending on indicators that are used as the basis for its assessment in a specific waterbody

Atmospheric pressure plasma jets (APPJs) are increasingly being used to functionalize polymers and dielectric materials for biomedical and biotechnology applications. Once such application is microfluidic labs-on-a-chip consisting of dielectric slabs with microchannel grooves hundreds of microns in width and depth. The periodic channels, an example of a complex surface, present challenges in terms of directly and uniformly exposing the surface to the plasma. In this paper, we discuss results from computational and experimental investigations of negative APPJs sustained in Ar/N2 mixtures flowing into ambient air and incident onto a series of microchannels. Results from two-dimensional plasma hydrodynamics modeling are compared to experimental measurements of electric field and fast-camera imaging. The propagation of the plasma across dry microchannels largely consists of a sequence of surface ionization waves (SIWs) on the top ridges of the channels and bulk ionization waves (IWs) crossing over the channels. The IWs are directed into electric field enhanced vertices of the next ridge. The charging of these ridges produce reverse IWs responsible for the majority of the ionization. The propagation of the plasma across water filled microchannels evolve into hopping SIWs between the leading edges of the water channels, regions of electric enhancement due to polarization of the water. Positive, reverse IWs follow the pre-ionized path of the initial negative waves. [ABSTRACT FROM AUTHOR]

Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in intracellular organelles are an emerging and exciting research arena. We summarize herein the current literature for rhythmicity in major intracellular organelles in mammals. These include changes in the morphology, content, and functions of different intracellular organelles. While these data highlight the presence of rhythmicity in these organelles, a gap remains in our knowledge regarding the underlying molecular mechanisms and their functional significance. Finally, we discuss the importance and challenges faced by spatio-temporal studies on these organelles and speculate on the presence of oscillators in organelles and their potential mode of communication. As circadian biology has been and continues to be studied throughout temporal and spatial axes, circadian organelles appear to be the next frontier.

Purpose : To evaluate the impact of supplemental external beam radiation therapy (EBRT) prior to permanent prostate brachytherapy on long term urinary, bowel, and erectile function. Material and methods : Patient administered urinary, bowel, and erectile quality of life (QoL) instrument were obtained prior to treatment and following brachytherapy. The study population was comprised of the 457 patients who were alive as of June 2016, had been randomized to two markedly different supplemental EBRT dose regimens and a third arm without supplemental EBRT, and had completed the June 2016 QoL survey. The need for urinary or bowel surgical intervention was prospectively recorded during routine follow-up. Multiple parameters were evaluated for effect on outcomes. Results : The urinary catheter was removed on day 0 in 92.1% of patients and 0.4% required a post-implant transurethral prostatic resection (TURP). On average, the International Prostate Symptom Score (IPSS) normalized at week 14. The 10-year rate of urethral strictures was 5.3%. No significant differences were discerned between baseline and post-implant rectal function assessment score (RFAS), and no patient developed a rectal ulcer or fistula. The 10-year potency preservation rate was 50.3%. Supplemental EBRT did not affect urinary, bowel, or erectile function. Urethral strictures were most closely related to bulbomembranous urethral brachytherapy doses, post-implant rectal function to pre-implant hemorroidal bleeding, and RFAS and erectile function to pre-brachytherapy international index of erectile function and age. Conclusions : Supplemental EBRT did not significantly effect catheter dependency, IPSS resolution, urethral stricture rate, the need for post-implant TURP, bowel, or erectile function. Careful attention to brachytherapy dose distributions appears to be most important in minimizing post-brachytherapy morbidity.

The aim: to analyze the clinical effect of MBST-exposure monotherapy, a magnetic resonance method, on the pain syndrome caused by degenerative dystrophic changes of vertebral column structures. Material and Methods. 132 patients both male and female with cervical and lumbar dorsopathy were enrolled into the study. Treatment course included 9 sessions of 60 min. daily. MRI-results of corresponding spine regions and visual analogue pain intensity scale were used as assessment tools for treatment efficiency before, immediately after, 3, 6 and 12 months after MBST-treatment. Results. The objective results of structural transformation of pathological formations in vertebral motional segments correlated with significant decrease of pain syndrome at all stages of control tests. Conclusion. MBST-exposure is an effective method of non-invasive, notouch monotherapy for patients with chronic dorsalgia caused by degenerative dorsopathy.

Purpose: To evaluate prostate-cancer specific mortality (PCSM) in a cohort of high-risk patients treated with a permanent prostate brachytherapy approach, stratified by pre-treatment PSA. Material and methods : 448 high-risk patients (NCCN criteria) underwent permanent prostate brachytherapy. High risk patients were stratified by pre-treatment PSA (≤ 10.0, 10.1-20, and > 20 ng/ml). Biochemical failure (BF), prostate cancer-specific mortality (PCSM), distant failure (DM), and overall mortality (OM) were assessed as a function of prognostic group. Multiple clinical, treatment, and dosimetric parameters were evaluated for impact on outcome. Results : The 10-year OM, BF, and PCSM for the entire cohort were 28.5%, 13.3%, and 4.9%, respectively. At 10 years, PCSM was 2.5%, 10.7%, and 4.5% in the PSA ≤ 10, 10.1-20, and > 20 ng/ml groups, respectively. No statistically significant differences in BF or overall survival (OS) were noted when stratified by pre-treatment PSA. DF was the most common in the 10.1-20 ng/ml cohort (8.6% at 10 years). In multivariate analysis, PCSM was most closely related to percent positive biopsies (p = 0.001) and tobacco (p = 0.042). Conclusions : High-risk prostate cancer treated with permanent prostate brachytherapy and supplemental external beam radiotherapy resulted in excellent long-term biochemical control and PCSM. Overall, PCSM was low in all cohorts but highest in the intermediate PSA group (10.1-20 ng/ml).

Stimulant effect of radiation on the mycorrhizal behavior of seedlings and parental individuals of Scotch pine, English oak tree, European fir at MED = 120 ... 270 microR / h and inhibitory effect at MED = 500 ... 1000 mcR / h is considered.

Mirror visual feedback (MVF) is potentially a powerful tool to facilitate recovery of disordered movement and stimulate activation of under-active brain areas due to stroke. The neural mechanisms underlying MVF have therefore been a focus of recent inquiry. Although it is known that sensorimotor areas can be activated via mirror feedback, the network interactions driving this effect remain unknown. The aim of the current study was to fill this gap by using dynamic causal modeling to test the interactions between regions in the frontal and parietal lobes that may be important for modulating the activation of the ipsilesional motor cortex during mirror visual feedback of unaffected hand movement in stroke patients. Our intent was to distinguish between two theoretical neural mechanisms that might mediate ipsilateral activation in response to mirror-feedback: transfer of information between bilateral motor cortices versus recruitment of regions comprising an action observation network which in turn modulate the motor cortex. In an event-related fMRI design, fourteen chronic stroke subjects performed goal-directed finger flexion movements with their unaffected hand while observing real-time visual feedback of the corresponding (veridical) or opposite (mirror) hand in virtual reality. Among 30 plausible network models that were tested, the winning model revealed significant mirror feedback-based modulation of the ipsilesional motor cortex arising from the contralesional parietal cortex, in a region along the rostral extent of the intraparietal sulcus. No winning model was identified for the veridical feedback condition. We discuss our findings in the context of supporting the latter hypothesis, that mirror feedback-based activation of motor cortex may be attributed to engagement of a contralateral (contralesional) action observation network. These findings may have important implications for identifying putative cortical areas, which may be targeted with non-invasive brain stimulation as a means of potentiating the effects of mirror training.