12,322 results on '"A, Meaney"'
Search Results
202. 292. A Multi-Modal Neuroimaging-Based Brain Age Model From Early to Mid-Childhood
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Chan, Shi Yu, primary, Huang, Pei, additional, Ngoh, Zhen Ming, additional, Lee, Janice J.Y., additional, Chuah, Jasmine, additional, Manahan, Aisleen M.A., additional, Fortier, Marielle V., additional, Wang, Dennis, additional, Meaney, Michael J., additional, and Tan, Ai Peng, additional
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- 2024
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203. 277. Permissive Parenting Mediates the Association Between Maternal Depression and Anhedonia in Children
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Manahan, Aisleen M.A., primary, Chan, Shi Yu, additional, Ngoh, Zhen Ming, additional, Chuah, Jasmine, additional, Meaney, Michael J., additional, Tan, Ai Peng, additional, Kee, Michelle Z.L., additional, and Huang, Pei, additional
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- 2024
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204. Effects of drive pulse shape on graded metal pushered single shell capsule implosions on the National Ignition Facility
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Dewald, E. L., primary, MacLaren, S. A., additional, Ho, D. D.-M., additional, Martinez, D. A., additional, Pino, J. E., additional, Tipton, R. E., additional, Young, C. V., additional, Horwood, C., additional, Divol, L., additional, Rubery, M. S., additional, Moore, A., additional, Vazsonyi, A. R., additional, Mellos, G., additional, Montgomery, W., additional, Smalyuk, V. A., additional, Graziani, F., additional, Monzon, E., additional, Prisbrey, S. T., additional, Whitley, H. D., additional, Xu, H., additional, Huang, H., additional, Kong, C., additional, Ratledge, M., additional, Volegov, P., additional, Freeman, M. S., additional, Wilde, C., additional, and Meaney, K., additional
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- 2024
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205. 313. Gestational Food Restriction and Insulin Sensitivity in Rats: A Transcriptomic Analysis in the Nucleus Accumbens Across Developmental Stages
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Alberry, Bonnie, primary, Barth, Barbara, additional, Batra, Aashita, additional, Alves, Marcio Bonesso, additional, O'Toole, Nicholas, additional, Zhang, Tie Yuan, additional, Wen, Xianglan, additional, Arcego, Danusa Mar, additional, Dalle Molle, Roberta, additional, Laureano, Daniela Pereira, additional, Lupinsky, Derek, additional, Miguel, Patricia, additional, Meaney, Michael, additional, and Silveira, Patricia Pelufo, additional
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- 2024
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206. A Meta-Analysis of Sensitive Periods for the Effects of Childhood Adversity on DNA Methylation
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Lussier, Alexandre, primary, Wood, Natasha, additional, Fischer, Jonah, additional, Luo, Mannan, additional, Melton, Phillip, additional, Neumann, Alexander, additional, Tuhkanen, Johanna, additional, Ware, Erin, additional, Cecil, Charlotte, additional, Cohen-Woods, Sarah, additional, Felix, Janine, additional, Huang, Rae-Chi, additional, Hivert, Marie-France, additional, Koss, Kalsea, additional, Lahti, Jari, additional, Meaney, Michael, additional, Meier, Helen, additional, Mitchell, Colter, additional, Notterman, Daniel, additional, O'Donnell, Kieran, additional, Räikkönen, Katri, additional, Relton, Caroline, additional, Sammallahti, Sara, additional, Schneper, Lisa, additional, Ressler, Kerry, additional, Simpkin, Andrew, additional, Suderman, Matthew, additional, Walton, Esther, additional, Smith, Andrew, additional, and Dunn, Erin, additional
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- 2024
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207. Review of A Dublin Magdalene Laundry: Donnybrook and Church-State Power in Ireland, by Mark Coen, Katherine O'Donnell and Maeve O'Rourke (eds.)
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Meaney, Niamh, primary
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- 2024
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208. White matter fibre density in the brain's inhibitory control network is associated with falling in older adults
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Simon, Colin, primary, Bolton, David, additional, Meaney, James, additional, Kenny, Rose Anne, additional, Simon, Vivienne, additional, Looze, Céline De, additional, Knight, Silvin, additional, and Ruddy, Kathy, additional
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- 2024
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209. Early childhood pre-service teachers’ preparation for using technology with children: a systematic literature review
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Papavlasopoulou, Sofia, primary, Undheim, Marianne, additional, Meaney, Tamsin, additional, and Esmaeeli, Sara, additional
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- 2024
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210. Lek med problemer
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Trude Fosse, Troels Lange, and Tamsin Meaney
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lek ,problemstilling ,problemløsning ,regnefortellinger ,Special aspects of education ,LC8-6691 - Abstract
Med gjeninnføring av lek i skolens læreplan er det behov for å vurdere hvordan lek har vært knyttet til matematikk i barnehagen. Vi bruker en modell som kobler sammen barns lek med det å stille og å løse problemer, til å analysere barnehagebarns engasjement med digitale apper og til andreklassingers skriving av regnefortellinger. Analysen viser hvordan lek kan oppstå når barna stiller problemer, og når de prøver ut ulike løsningsstrategier. Vi anser at resultatet av forskningen kan gi innsikt til matematikklærere i de første skoleårene om lekens potensial i arbeid med problemstilling og problemløsning. English abstract Play with problems With the reintroduction of play in the school’s curriculum, there is a need to assess how play has been linked to mathematics in kindergarten. We use a model that connects children’s play with posing and solving problems to analyse kindergarten children’s involvement with digital apps and 2nd grade students’ writing of regnefortellinger or number stories. The analysis shows how play can occur when the children pose problems and when they try out different solution strategies. We believe that the results of the research can provide insight to mathematics teachers in the first years of school about the potential for play in problem posing and problem solving.
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- 2023
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211. Special issue on mathematics in early childhood education
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Tamsin Meaney, Elin Kirsti Lie Reikerås, and Camilla N. Justnes
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mathematics in early childhood education ,Special aspects of education ,LC8-6691 - Abstract
"Mathematics is an important part of children’s daily life. The value of mathematics for young children is reflected in curricula for early childhood in the Nordic countries and consequently, mathematics education courses are included in teacher education for early childhood. However, mathematics in early childhood education is understood in different ways, influenced by both politics and research, and practitioners’ approach to the field. As a field of research, mathematics education for young children is fairly new in the Nordic countries."
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- 2023
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212. COVID-19 vaccination recommendations and practices for women of reproductive age, U.S. Physicians, Fall 2021
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Mehreen Meghani, Lauren B. Zapata, Kara Polen, Romeo R. Galang, Hilda Razzaghi, Dana Meaney-Delman, and Sascha Ellington
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Primary care physicians ,COVID-19 vaccination ,Pregnant women ,Reproductive health ,DocStyles ,Medicine - Abstract
Pregnant people with COVID-19 are at increased risk for severe illness and adverse pregnancy outcomes. COVID-19 vaccinations are safe and effective, including for pregnant and recently pregnant people. The objective of this analysis was to describe the extent to which primary care physicians across the United States report confidence in talking with female patients of reproductive age about COVID-19 vaccination, recommending COVID-19 vaccinations to pregnant patients, and offering COVID-19 vaccinations at their practices in fall 2021.We analyzed cross-sectional data from the Fall 2021 DocStyles survey, a web-based panel survey of U.S. primary healthcare providers (64% response rate). Family practitioners/internists, obstetrician-gynecologists, and pediatricians were asked about confidence in talking with female patients of reproductive age about COVID-19 vaccination, vaccination practices regarding pregnant patients, and offering COVID-19 vaccinations. We describe results overall and by select physician characteristics. Among 1501 respondents, most were family practitioners/internists (67%), 17% were obstetrician-gynecologists, and 17% were pediatricians. Overall, 63% were very confident talking with female patients of reproductive age about COVID-19 vaccination, 80% recommended pregnant patients get vaccinated as soon as possible, and 50% offered COVID-19 vaccinations at their current practice. Obstetrician-gynecologists were most confident in talking with female patients, but only one-third offered the vaccine at their practices. This analysis found that most physicians felt confident talking about COVID-19 vaccinations and recommended pregnant patients get vaccinated as soon as possible. Provider recommendation for vaccination remains a key strategy for achieving high vaccination coverage, and consistent recommendations may improve vaccine acceptance among pregnant and postpartum people.
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- 2023
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213. Patient Experience With Resident Versus Staff Physicians: Results From a Cross-Sectional Patient Survey From Canadian Family Medicine Residencies
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Doherty, Sean, primary, Agarwal, Payal, additional, Wang, Ri, additional, Meaney, Christopher, additional, Eldridge, Kirsten, additional, Damji, Ali N., additional, Elman, Debbie, additional, Fung, Susanna, additional, Gupta, Karuna L., additional, Walji, Sakina, additional, Weber, Linda, additional, Witty, Melissa, additional, and Kiran, Tara, additional
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- 2024
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214. Identifying functional multi-host shuttle plasmids to advance synthetic biology applications in Mesorhizobium and Bradyrhizobium
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Meaney, Jordyn S., primary, Panchal, Aakanx K., additional, Wilcox, Aiden J., additional, diCenzo, George C, additional, and Karas, Bogumil, additional
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- 2024
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215. Chronic disease prevention and screening outcomes for patients with and without financial difficulty: a secondary analysis of the BETTER WISE cluster randomised controlled trial
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Aubrey-Bassler, Kris, primary, Patel, Dhruvesh, additional, Fernandes, Carolina, additional, Lofters, Aisha K, additional, Campbell-Scherer, Denise, additional, Meaney, Christopher, additional, Moineddin, Rahim, additional, Wong, Tracy, additional, Pinto, Andrew David, additional, Shea-Budgell, Melissa, additional, McBrien, Kerry, additional, Grunfeld, Eva, additional, and Manca, Donna P, additional
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- 2024
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216. Atypical brain aging and its association with working memory performance in major depressive disorder
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Ho, Natalie C.W., primary, Bethlehem, Richard AI., additional, Seidlitz, Jakob, additional, Nogovitsyn, Nikita, additional, Metzak, Paul, additional, Ballester, Pedro L., additional, Hassel, Stefanie, additional, Rotzinger, Susan, additional, Poppenk, Jordan, additional, Lam, Raymond W., additional, Taylor, Valerie H., additional, Milev, Roumen, additional, Adamson, Chris, additional, Adler, Sophie, additional, Alexander-Bloch, Aaron F., additional, Anagnostou, Evdokia, additional, Anderson, Kevin M., additional, Areces-Gonzalez, Ariosky, additional, Astle, Duncan E., additional, Auyeung, Bonnie, additional, Ayub, Muhammad, additional, Bae, Jong Bin, additional, Ball, Gareth, additional, Baron-Cohen, Simon, additional, Beare, Richard, additional, Bedford, Saashi A., additional, Benegal, Vivek, additional, Bethlehem, Richard A.I., additional, Beyer, Frauke, additional, Blangero, John, additional, Blesa Cábez, Manuel, additional, Boardman, James P., additional, Borzage, Matthew, additional, Bosch-Bayard, Jorge F., additional, Bourke, Niall, additional, Bullmore, Edward T., additional, Calhoun, Vince D., additional, Chakravarty, Mallar M., additional, Chen, Christina, additional, Chertavian, Casey, additional, Chetelat, Gaël, additional, Chong, Yap S., additional, Corvin, Aiden, additional, Costantino, Manuela, additional, Courchesne, Eric, additional, Crivello, Fabrice, additional, Cropley, Vanessa L., additional, Crosbie, Jennifer, additional, Crossley, Nicolas, additional, Delarue, Marion, additional, Delorme, Richard, additional, Desrivieres, Sylvane, additional, Devenyi, Gabriel, additional, Di Biase, Maria A., additional, Dolan, Ray, additional, Donald, Kirsten A., additional, Donohoe, Gary, additional, Dorfschmidt, Lena, additional, Dunlop, Katharine, additional, Edwards, Anthony D., additional, Elison, Jed T., additional, Ellis, Cameron T., additional, Elman, Jeremy A., additional, Eyler, Lisa, additional, Fair, Damien A., additional, Fletcher, Paul C., additional, Fonagy, Peter, additional, Franz, Carol E., additional, Galan-Garcia, Lidice, additional, Gholipour, Ali, additional, Giedd, Jay, additional, Gilmore, John H., additional, Glahn, David C., additional, Goodyer, Ian M., additional, Grant, P.E., additional, Groenewold, Nynke A., additional, Gudapati, Shreya, additional, Gunning, Faith M., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Hammill, Christopher F., additional, Hansson, Oskar, additional, Hedden, Trey, additional, Heinz, Andreas, additional, Henson, Richard N., additional, Heuer, Katja, additional, Hoare, Jacqueline, additional, Holla, Bharath, additional, Holmes, Avram J., additional, Huang, Hao, additional, Ipser, Jonathan, additional, Jack, Clifford R., additional, Jackowski, Andrea P., additional, Jia, Tianye, additional, Jones, David T., additional, Jones, Peter B., additional, Kahn, Rene S., additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, Kawashima, Ryuta, additional, Kelley, Elizabeth A., additional, Kern, Silke, additional, Kim, Ki-Woong, additional, Kitzbichler, Manfred G., additional, Kremen, William S., additional, Lalonde, François, additional, Landeau, Brigitte, additional, Lerch, Jason, additional, Lewis, John D., additional, Li, Jiao, additional, Liao, Wei, additional, Liston, Conor, additional, Lombardo, Michael V., additional, Lv, Jinglei, additional, Mallard, Travis T., additional, Marcelis, Machteld, additional, Mathias, Samuel R., additional, Mazoyer, Bernard, additional, McGuire, Philip, additional, Meaney, Michael J., additional, Mechelli, Andrea, additional, Misic, Bratislav, additional, Morgan, Sarah E., additional, Mothersill, David, additional, Ortinau, Cynthia, additional, Ossenkoppele, Rik, additional, Ouyang, Minhui, additional, Palaniyappan, Lena, additional, Paly, Leo, additional, Pan, Pedro M., additional, Pantelis, Christos, additional, Park, Min Tae M., additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Paz-Linares, Deirel, additional, Pichet Binette, Alexa, additional, Pierce, Karen, additional, Qian, Xing, additional, Qiu, Anqi, additional, Raznahan, Armin, additional, Rittman, Timothy, additional, Rodrigue, Amanda, additional, Rollins, Caitlin K., additional, Romero-Garcia, Rafael, additional, Ronan, Lisa, additional, Rosenberg, Monica D., additional, Rowitch, David H., additional, Salum, Giovanni A., additional, Satterthwaite, Theodore D., additional, Schaare, H. Lina, additional, Schabdach, Jenna, additional, Schachar, Russell J., additional, Schöll, Michael, additional, Schultz, Aaron P., additional, Sharp, David, additional, Shinohara, Russell T., additional, Skoog, Ingmar, additional, Smyser, Christopher D., additional, Sperling, Reisa A., additional, Stein, Dan J., additional, Stolicyn, Aleks, additional, Suckling, John, additional, Sullivan, Gemma, additional, Thyreau, Benjamin, additional, Toro, Roberto, additional, Traut, Nicolas, additional, Tsvetanov, Kamen A., additional, Turk-Browne, Nicholas B., additional, Tuulari, Jetro J., additional, Tzourio, Christophe, additional, Vachon-Presseau, Étienne, additional, Valdes-Sosa, Mitchell J., additional, Valdes-Sosa, Pedro A., additional, Valk, Sofie L., additional, van Amelsvoort, Therese, additional, Vandekar, Simon N., additional, Vasung, Lana, additional, Vértes, Petra E., additional, Victoria, Lindsay W., additional, Villeneuve, Sylvia, additional, Villringer, Arno, additional, Vogel, Jacob W., additional, Wagstyl, Konrad, additional, Wang, Yin-Shan S., additional, Warfield, Simon K., additional, Warrier, Varun, additional, Westman, Eric, additional, Westwater, Margaret L., additional, Whalley, Heather C., additional, White, Simon R., additional, Witte, A. Veronica, additional, Yang, Ning, additional, Yeo, B.T. Thomas, additional, Yun, Hyuk Jin, additional, Zalesky, Andrew, additional, Zar, Heather J., additional, Zettergren, Anna, additional, Zhou, Juan H., additional, Ziauddeen, Hisham, additional, Zimmerman, Dabriel, additional, Zugman, Andre, additional, Zuo, Xi-Nian N., additional, Frey, Benicio N., additional, Harkness, Kate L., additional, Addington, Jean, additional, and Kennedy, Sidney H., additional
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- 2024
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217. Radiogenomics: Contemporary Applications in the Management of Rectal Cancer
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Niall J. O’Sullivan, Hugo C. Temperley, Michelle T. Horan, Alison Corr, Brian J. Mehigan, John O. Larkin, Paul H. McCormick, Dara O. Kavanagh, James F. M. Meaney, and Michael E. Kelly
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radiomics ,radiogenomics ,oncology ,rectal cancer ,survival ,recurrence ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic testing via the development of ‘imaging biomarkers’ that have the potential to serve as an alternative ‘liquid-biopsy’ in the determination of tumour biological characteristics. Radiogenomics also harnesses the potential to unlock aspects of tumour biology which are not possible to assess by conventional biopsy-based methods, such as full tumour burden, intra-/inter-lesion heterogeneity and the possibility of providing the information of tumour biology longitudinally. Several studies have shown the feasibility of developing a radiogenomic-based signature to predict treatment outcomes and tumour characteristics; however, many lack prospective, external validation. We performed a systematic review of the current literature surrounding the use of radiogenomics in rectal cancer to predict underlying tumour biology.
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- 2023
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218. Improving Cardiovascular Risk in Postmenopausal Women with an (−)-Epicatechin-Based Nutraceutical: A Randomly Assigned, Double-Blind vs. Placebo, Proof-of-Concept Trial
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Nayelli Nájera, Miguel Ortíz-Flores, Javier Pérez-Durán, Enrique Reyes-Muñoz, José Romo-Yañez, Guillermo Ortiz-Luna, Francisco Villarreal, Eduardo Meaney, Guillermo Ceballos, and Araceli Montoya-Estrada
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cardiovascular risk ,lipoprotein subfractionation profile ,epicatechin ,(−)-epicatechin-enriched cacao ,Medicine - Abstract
Background: Age-adjusted rates of cardiovascular disease (CVD) are higher in men than in women. CVD risk-factor outcomes are underrecognized, underestimated, and undertreated in women because the clinical expressions in women differ from those of men. There are no universally accepted recommendations on what to do in women when the values of fasting glucose, blood pressure, and lipids are only slightly altered or at borderline values. We reported the positive effects on CVD risk markers using cacao by-products, showing that alternative approaches can be used to prevent cardiovascular disease in women. The objective was to evaluate the changes in lipoprotein subfractions induced by three months of treatment with an epicatechin-enriched cacao supplement. Methods: A double-blind, placebo-controlled proof-of-concept study was developed to evaluate the effects of 3 months of treatment with an (−)-epicatechin-enriched cacao supplement on lipoprotein subfractions. Results: The usual screening workshop for postmenopausal women could be insufficient and misleading. Assessing the effect of a (−)-epicatechin-enriched cacao supplement employing a lipoprotein subfractionation profile analysis suggests a decrease in cardiovascular risk. Conclusions: A simple, low-cost, safe (−)-epicatechin-enriched cacao supplement product can improve the cardiovascular risk in postmenopausal women.
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- 2023
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219. The Role of COVID-19 in Molding the Economy and Social Inequity of Mexican Households
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Tonatiuh Suárez-Meaney, Ioannis Chatziioannou, Héctor Daniel Reséndiz López, Luis Chias-Becerril, and Efthimios Bakogiannis
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COVID-19 ,household expenditure ,pandemic ,inequity ,Social Sciences - Abstract
The COVID-19 pandemic has deeply influenced the economy of all nations, and Mexico is no exception. This effect is distinct for different groups of the population, with variable socio-economic and demographic characteristics, that live in regions of contrasting features. An efficient apparatus for measuring expenditure variations and tendency is the National Household Income and Expenditure Survey performed by the National Institute of Statistics and Geography in accordance with the international standardization established at the Canberra Conference; the latter permits, every two years, for different surveys to be comparable in time and space. Hence, in Mexico, there are three surveys for 2018, 2020, and 2022. The results of the comparison indicate that different groups of the Mexican population have experienced the pandemic with multiple impacts, apparently without large proportional variation regarding expenditure but with greater variation in time-use conditions. Moreover, it became apparent that even though the lower strata of Mexico’s population have fewer proportional variations concerning income after the COVID-19 outburst, they must incorporate more family members into working activities to achieve a survival line; the latter results in the abandonment of school from various young household members that will negatively impact the quality of their lives in the long term.
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- 2023
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220. Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children
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Restrepo-Lozano, Jose M., Pokhvisneva, Irina, Wang, Zihan, Patel, Sachin, Meaney, Michael J., Silveira, Patricia P., and Flores, Cecilia
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- 2022
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221. Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behaviour, and body composition in children
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Jaramillo-Ospina, Angela, Casanello, Paola, Garmendia, María Luisa, Andersen, Ross, Levitan, Robert D., Meaney, Michael J., and Silveira, Patricia Pelufo
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- 2022
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222. Brain charts for the human lifespan
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Bethlehem, R. A. I., Seidlitz, J., White, S. R., Vogel, J. W., Anderson, K. M., Adamson, C., Adler, S., Alexopoulos, G. S., Anagnostou, E., Areces-Gonzalez, A., Astle, D. E., Auyeung, B., Ayub, M., Bae, J., Ball, G., Baron-Cohen, S., Beare, R., Bedford, S. A., Benegal, V., Beyer, F., Blangero, J., Blesa Cábez, M., Boardman, J. P., Borzage, M., Bosch-Bayard, J. F., Bourke, N., Calhoun, V. D., Chakravarty, M. M., Chen, C., Chertavian, C., Chetelat, G., Chong, Y. S., Cole, J. H., Corvin, A., Costantino, M., Courchesne, E., Crivello, F., Cropley, V. L., Crosbie, J., Crossley, N., Delarue, M., Delorme, R., Desrivieres, S., Devenyi, G. A., Di Biase, M. A., Dolan, R., Donald, K. A., Donohoe, G., Dunlop, K., Edwards, A. D., Elison, J. T., Ellis, C. T., Elman, J. A., Eyler, L., Fair, D. A., Feczko, E., Fletcher, P. C., Fonagy, P., Franz, C. E., Galan-Garcia, L., Gholipour, A., Giedd, J., Gilmore, J. H., Glahn, D. C., Goodyer, I. M., Grant, P. E., Groenewold, N. A., Gunning, F. M., Gur, R. E., Gur, R. C., Hammill, C. F., Hansson, O., Hedden, T., Heinz, A., Henson, R. N., Heuer, K., Hoare, J., Holla, B., Holmes, A. J., Holt, R., Huang, H., Im, K., Ipser, J., Jack, Jr, C. R., Jackowski, A. P., Jia, T., Johnson, K. A., Jones, P. B., Jones, D. T., Kahn, R. S., Karlsson, H., Karlsson, L., Kawashima, R., Kelley, E. A., Kern, S., Kim, K. W., Kitzbichler, M. G., Kremen, W. S., Lalonde, F., Landeau, B., Lee, S., Lerch, J., Lewis, J. D., Li, J., Liao, W., Liston, C., Lombardo, M. V., Lv, J., Lynch, C., Mallard, T. T., Marcelis, M., Markello, R. D., Mathias, S. R., Mazoyer, B., McGuire, P., Meaney, M. J., Mechelli, A., Medic, N., Misic, B., Morgan, S. E., Mothersill, D., Nigg, J., Ong, M. Q. W., Ortinau, C., Ossenkoppele, R., Ouyang, M., Palaniyappan, L., Paly, L., Pan, P. M., Pantelis, C., Park, M. M., Paus, T., Pausova, Z., Paz-Linares, D., Pichet Binette, A., Pierce, K., Qian, X., Qiu, J., Qiu, A., Raznahan, A., Rittman, T., Rodrigue, A., Rollins, C. K., Romero-Garcia, R., Ronan, L., Rosenberg, M. D., Rowitch, D. H., Salum, G. A., Satterthwaite, T. D., Schaare, H. L., Schachar, R. J., Schultz, A. P., Schumann, G., Schöll, M., Sharp, D., Shinohara, R. T., Skoog, I., Smyser, C. D., Sperling, R. A., Stein, D. J., Stolicyn, A., Suckling, J., Sullivan, G., Taki, Y., Thyreau, B., Toro, R., Traut, N., Tsvetanov, K. A., Turk-Browne, N. B., Tuulari, J. J., Tzourio, C., Vachon-Presseau, É., Valdes-Sosa, M. J., Valdes-Sosa, P. A., Valk, S. L., van Amelsvoort, T., Vandekar, S. N., Vasung, L., Victoria, L. W., Villeneuve, S., Villringer, A., Vértes, P. E., Wagstyl, K., Wang, Y. S., Warfield, S. K., Warrier, V., Westman, E., Westwater, M. L., Whalley, H. C., Witte, A. V., Yang, N., Yeo, B., Yun, H., Zalesky, A., Zar, H. J., Zettergren, A., Zhou, J. H., Ziauddeen, H., Zugman, A., Zuo, X. N., Bullmore, E. T., and Alexander-Bloch, A. F.
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- 2022
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223. Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress
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Caradonna, Salvatore G., Zhang, Tie-Yuan, O’Toole, Nicholas, Shen, Mo-Jun, Khalil, Huzefa, Einhorn, Nathan R., Wen, Xianglan, Parent, Carine, Lee, Francis S., Akil, Huda, Meaney, Michael J., McEwen, Bruce S., and Marrocco, Jordan
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- 2022
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224. Tomographic X-ray data of 3D cross phantom
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Latva-Äijö, Salla, Meaney, Alexander, and Siltanen, Samuli
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Physics - Medical Physics - Abstract
This is the documentation of the tomographic X-ray data of cross phantom made available at this https URL The data can be freely used for scientific purposes with appropriate references to the data and to this document in arxiv.org. The data set consists of (1) the X-ray sinogram with 16 or 30 time frames (depending on theresolution) of 2D slices of the phantom and (2) the corresponding static and dynamic measurement matrices modeling the linear operation of the X-ray transform. Each of these sinograms was obtained from a measured 360-projection fan-beam sinogram by down-sampling and taking logarithms. The original (measured) sinogram is also provided in its original form and resolution., Comment: 14 pages, 24 figures. arXiv admin note: substantial text overlap with arXiv:1802.09397, arXiv:1609.07299, arXiv:1705.05732, arXiv:1502.04064
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- 2018
225. Tomographic X-ray data of 3D emoji
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Meaney, Alexander, Purisha, Zenith, and Siltanen, Samuli
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Physics - Medical Physics - Abstract
This is the documentation of the tomographic X-ray data of emoji phantom made available at https://zenodo.org/record/1183532#.WpA35Y5rIy1. The data can be freely used for scientific purposes with appropriate references to the data and to this document in arxiv.org. The data set consists of (1) the X-ray sinogram of a single 2D slice of 33 emoji faces (contains 15 different emoji faces) made by small squared ceramic stones and (2) the corresponding static and dynamic measurement matrices modeling the linear operation of the X-ray transform. Each of these sinograms was obtained from a measured 60-projection fan-beam sinogram by down-sampling and taking logarithms. The original (measured) sinogram is also provided in its original form and resolution. The original (measured) sinogram is also provided in its original form and resolution., Comment: arXiv admin note: substantial text overlap with arXiv:1609.07299, arXiv:1705.05732, arXiv:1502.04064
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- 2018
226. Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine
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Carazo-Arias, Elena, Nguyen, Phi T., Kass, Marley, Jee, Hyun Jung, Nautiyal, Katherine M., Magalong, Valerie, Coie, Lilian, Andreu, Valentine, Gergues, Mark M., Khalil, Huzefa, Akil, Huda, Arcego, Danusa Mar, Meaney, Michael, Anacker, Christoph, Samuels, Benjamin A., Pintar, John E., Morozova, Irina, Kalachikov, Sergey, and Hen, Rene
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- 2022
- Full Text
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227. Characteristics and treatment of hospitalized pregnant women with COVID-19
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Sekkarie, Ahlia, Woodruff, Rebecca, Whitaker, Michael, Kramer, Michael R., Zapata, Lauren B., Ellington, Sascha R., Meaney-Delman, Dana M., Pham, Huong, Patel, Kadam, Taylor, Christopher A., Chai, Shua J., Kawasaki, Breanna, Meek, James, Openo, Kyle P., Weigel, Andy, Leegwater, Lauren, Como-Sabetti, Kathryn, Ropp, Susan L., Muse, Alison, Bennett, Nancy M., Billing, Laurie M., Sutton, Melissa, Talbot, H. Keipp, Hill, Mary, and Havers, Fiona P.
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- 2022
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228. Curatr: A Platform for Semantic Analysis and Curation of Historical Literary Texts.
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Susan Leavy, Gerardine Meaney, Karen Wade, and Derek Greene
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- 2023
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229. Comparing Variation in Tokenizer Outputs Using a Series of Problematic and Challenging Biomedical Sentences.
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Christopher Meaney, Therese A. Stukel, Peter C. Austin, and Michael D. Escobar
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- 2023
- Full Text
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230. Comparing feature selection and machine learning approaches for predicting CYP2D6 methylation from genetic variation.
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Wei Jing Fong, Hong Ming Tan, Rishabh Garg, Ai Ling Teh, Hong Pan, Varsha Gupta, Bernadus Krishna, Zou Hui Chen, Natania Yovela Purwanto, Fabian Yap, Kok Hian Tan, Kok Yen Jerry Chan, Shiao-Yng Chan, Nicole Goh, Nikita Rane, Ethel Siew Ee Tan, Yuheng Jiang, Mei Han, Michael J. Meaney 0001, Dennis Wang, Jussi Keppo, and Geoffrey Chern-Yee Tan
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- 2023
- Full Text
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231. En busca de una escala de riesgo adecuada para los mexicanos. Las insuficiencias de la escala Globorisk
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Meaney, Alejandra, primary, Martínez-Marroquín, Martha Yolanda, additional, Samaniego-Méndez, Virginia, additional, Fernández-Barros, Carlos, additional, Hidalgo, Isabel, additional, Nájera, Nayeli, additional, Ceballos, Guillermo, additional, and Meaney, Eduardo, additional
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- 2024
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232. Theoretical Premises and Contemporary Optimizations of Microwave Tomography
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M. Meaney, Paul, primary and D. Paulsen, Keith, additional
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- 2022
- Full Text
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233. A Mastery Motivational Climate-Based Service-Learning Program: Physical and Psychosocial Benefits among Underserved Children
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Kipp, Lindsay E., Meaney, Karen S., and Griffin, L. Kent
- Abstract
We explored children's physical activity level and psychosocial outcomes in a service-learning program. The program, taught by preservice physical educators, engages children in fun activities within a mastery motivational climate (MMC). Forty-two children in grades K-4 wore accelerometers during two 90-min sessions, resulting in 84 data points. Forty-three children age 8 and up completed a postprogram survey assessing motivational climate, perceived competence, and personal and social responsibility. Of those, 27 completed a presurvey as well. On average, children were engaged in light activity for 38.6% and moderate-to-vigorous activity for 26.0% of the program time. Social responsibility improved from pre- to postassessment. Children perceived a high MMC, and regression analyses showed that MMC was positively related to perceived competence, personal responsibility, and social responsibility at the end of the program. Results suggest this program was effective in using an MMC to promote social responsibility while engaging students in light, moderate, and vigorous physical activity.
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- 2021
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234. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
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Czamara, Darina, Eraslan, Gökçen, Page, Christian M, Lahti, Jari, Lahti-Pulkkinen, Marius, Hämäläinen, Esa, Kajantie, Eero, Laivuori, Hannele, Villa, Pia M, Reynolds, Rebecca M, Nystad, Wenche, Håberg, Siri E, London, Stephanie J, O'Donnell, Kieran J, Garg, Elika, Meaney, Michael J, Entringer, Sonja, Wadhwa, Pathik D, Buss, Claudia, Jones, Meaghan J, Lin, David TS, MacIsaac, Julie L, Kobor, Michael S, Koen, Nastassja, Zar, Heather J, Koenen, Karestan C, Dalvie, Shareefa, Stein, Dan J, Kondofersky, Ivan, Müller, Nikola S, Theis, Fabian J, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Räikkönen, Katri, and Binder, Elisabeth B
- Subjects
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium ,Fetal Blood ,Humans ,DNA ,Risk Factors ,Cohort Studies ,DNA Methylation ,Epigenesis ,Genetic ,Pregnancy ,Genotype ,Infant ,Newborn ,Female ,Male ,Gene-Environment Interaction ,Genetics ,Pediatric ,Human Genome ,Prevention ,2.1 Biological and endogenous factors ,Epigenesis ,Genetic ,Infant ,Newborn ,MD Multidisciplinary - Abstract
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
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- 2019
235. Polygenic differential susceptibility to prenatal adversity
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Belsky, Jay, Pokhvisneva, Irina, Rema, Anu Sathyan Sathyapalan, Broekman, Birit FP, Pluess, Michael, O'Donnell, Kieran J, Meaney, Michael J, and Silveira, Patrícia P
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Biological Psychology ,Psychology ,Mental Health ,Prevention ,Basic Behavioral and Social Science ,Clinical Research ,Pediatric ,Genetics ,Genetic Testing ,Behavioral and Social Science ,2.1 Biological and endogenous factors ,Aetiology ,Anxiety ,Depression ,Female ,Gene-Environment Interaction ,Genetic Predisposition to Disease ,Humans ,Male ,Multifactorial Inheritance ,Pregnancy ,Prenatal Exposure Delayed Effects ,Problem Behavior ,Cognitive Sciences ,Developmental & Child Psychology ,Applied and developmental psychology ,Biological psychology ,Clinical and health psychology - Abstract
A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter-gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis-stress or differential-susceptibility related processes. Analyses of the regions of significance and proportion of interaction index are consistent with the diathesis-stress model, seemingly because of the truncated nature of the adversity score (which did not extend to supportive/positive prenatal experiences/exposures); in contrast, the proportion (of cases) affected index favors the differential-susceptibility model. These results suggest the need for future studies to extend measurement of the prenatal environment to highly supportive experiences and exposures.
- Published
- 2019
236. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
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Toepfer, Philipp, O'Donnell, Kieran J, Entringer, Sonja, Garg, Elika, Heim, Christine M, Lin, David TS, MacIsaac, Julia L, Kobor, Michael S, Meaney, Michael J, Provençal, Nadine, Binder, Elisabeth B, Wadhwa, Pathik D, and Buss, Claudia
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Pediatric ,Genetics ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,DNA Methylation ,Depression ,Postpartum ,Epigenesis ,Genetic ,Female ,Humans ,Infant ,Newborn ,Male ,Maternal Behavior ,Mother-Child Relations ,Oxytocin ,Postpartum Period ,Pregnancy ,Promoter Regions ,Genetic ,Receptors ,Oxytocin ,Maternal behavior ,DNA methylation ,Behavioral epigenetics ,Estrogen sensitivity ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biomedical and clinical sciences ,Psychology - Abstract
Maternal behavior (MB) is observable across mammals and represents an important feature of environmental variation during early postnatal development. Oxytocin (OT) plays a crucial role in MB. Even prior to childbirth, pregnancy induces epigenetic and other downstream changes in the maternal OT-system, likely mediated by the actions of steroid hormones. However, little is known about the nature and consequences of epigenetic modifications in the maternal OT-encoding gene (OXT) during pregnancy. Our study aims to investigate temporal dynamics of OXT promoter DNA methylation (DNAm) throughout pregnancy in predicting MB in humans. In 107 mother-child dyads, maternal OXT DNAm was serially analyzed in whole blood in early, mid and late pregnancy. MB was coded based on standardized mother-child interactions at six months postpartum. After controlling for cellular heterogeneity, race/ethnicity, age, and socioeconomic status, OXT-promoter DNAm exhibited a dynamic profile during pregnancy (b = 0.026, t=-3.37, p
- Published
- 2019
237. Responsiveness to Change of the Montreal Cognitive Assessment, Mini-Mental State Examination, and SCOPA-Cog in Non-Demented Patients with Parkinson’s Disease
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Faust-Socher, Achinoam, Duff-Canning, Sarah, Grabovsky, Arthur, Armstrong, Melissa J, Rothberg, Brandon, Eslinger, Paul J, Meaney, Christopher A, Schneider, Ruth B, Tang-Wai, David F, Fox, Susan H, Zadikoff, Cindy, Kennedy, Nancy, Chou, Kelvin L, Persad, Carol, Litvan, Irene, Mast, Benjamin T, Gerstenecker, Adam T, Weintraub, Sandra, Reginold, William, and Marras, Connie
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Parkinson's Disease ,Clinical Research ,Neurosciences ,Behavioral and Social Science ,Acquired Cognitive Impairment ,Neurodegenerative ,Dementia ,Mental Health ,Brain Disorders ,Aging ,Neurological ,Aged ,Aged ,80 and over ,Cognition ,Cognitive Dysfunction ,Disease Progression ,Female ,Humans ,Male ,Mental Status and Dementia Tests ,Middle Aged ,Neuropsychological Tests ,Parkinson Disease ,ROC Curve ,Reproducibility of Results ,Sensitivity and Specificity ,Mild cognitive impairment ,Responsiveness ,Parkinson's disease ,Cognitive decline ,Parkinson’s disease ,Clinical Sciences ,Cognitive Sciences ,Geriatrics - Abstract
BackgroundClinical monitoring of patients with Parkinson's disease (PD) for cognitive decline is an important element of care. The Montreal Cognitive Assessment (MoCA) has been proposed to be a sensitive tool for assessing cognitive impairment in PD. The aim of our study was to compare the responsiveness of the MoCA to decline in cognition to the responsiveness of the Mini Mental State Examination (MMSE) and the Scales for Outcomes of Parkinson's disease-cognition (SCOPA-Cog).MethodsPD patients without dementia were enrolled at 6 North American movement disorders centers between 2008 and 2011. Participants received annual evaluations including the MoCA, MMSE, and SCOPA-Cog followed by formal neuropsychological testing. The gold standard for change in cognition was defined as the change on the neuropsychological test scores over the annual assessments. The Reliable Change Method was used to provide an estimate of the probability that a given difference score would be obtained by chance. The sensitivity of the MoCA, MMSE, and SCOPA-Cog to change was quantified using receiver operating characteristics (ROC) curves.ResultsOne hundred seventeen patients were included in the analysis. Participants were followed at mean intervals of 11 ± 2 months for a median of 2 (maximum 5) visits. According to the reliable change index, 56 intervals of cognitive testing showed a decline in global cognition. ROC analysis of change in MoCA, MMSE, and SCOPA-Cog global scores compared to gold standard testing found an area under the curve (AUC) of 0.55 (95% CI 0.48-0.62), 0.56 (0.48-0.63), and 0.63 (0.55-0.70) respectively. There were no significant differences in the AUCs across the tests. The sensitivity of the MoCA, MMSE, and SCOPA-Cog to change at various thresholds for decline in scores reached a maximum of 71% for a cut-off of 1 point change on the SCOPA-Cog.ConclusionUsing neuropsychological testing as a gold standard comparator, the performance of the MoCA, MMSE, and SCOPA-Cog for detecting decline in non-demented PD patients over a 1-year interval is poor. This has implications for clinical practice; stable scores may not be taken as reassurance of the absence of cognitive decline.
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- 2019
238. Insured Not Entitled To A Windfall Under Cyber Policy's Business Interruption Insuring Agreement
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Meaney, Mallory
- Subjects
Business interruption insurance -- Cases ,Judgments -- Cases ,Lost profits damages -- Cases ,Company legal issue ,Business, international - Abstract
In a win for Wiley's client, the United States District Court for the Eastern District of Arkansas, applying Arkansas law, has held that a cyber policy's business interruption coverage should [...]
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- 2024
239. Neuroergonomic assessment of developmental coordination disorder
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Shawn Joshi, Benjamin D. Weedon, Patrick Esser, Yan-Ci Liu, Daniella N. Springett, Andy Meaney, Mario Inacio, Anne Delextrat, Steve Kemp, Tomás Ward, Hooshang Izadi, Helen Dawes, and Hasan Ayaz
- Subjects
Medicine ,Science - Abstract
Abstract Until recently, neural assessments of gross motor coordination could not reliably handle active tasks, particularly in realistic environments, and offered a narrow understanding of motor-cognition. By applying a comprehensive neuroergonomic approach using optical mobile neuroimaging, we probed the neural correlates of motor functioning in young people with Developmental Coordination Disorder (DCD), a motor-learning deficit affecting 5–6% of children with lifelong complications. Neural recordings using fNIRS were collected during active ambulatory behavioral task execution from 37 Typically Developed and 48 DCD Children who performed cognitive and physical tasks in both single and dual conditions. This is the first of its kind study targeting regions of prefrontal cortical dysfunction for identification of neuropathophysiology for DCD during realistic motor tasks and is one of the largest neuroimaging study (across all modalities) involving DCD. We demonstrated that DCD is a motor-cognitive disability, as gross motor /complex tasks revealed neuro-hemodynamic deficits and dysfunction within the right middle and superior frontal gyri of the prefrontal cortex through functional near infrared spectroscopy. Furthermore, by incorporating behavioral performance, decreased neural efficiency in these regions were revealed in children with DCD, specifically during motor tasks. Lastly, we provide a framework, evaluating disorder impact in ecologically valid contexts to identify when and for whom interventional approaches are most needed and open the door for precision therapies.
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- 2022
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240. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
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Xiangfei Meng, Michelle Wang, Kieran J. O’Donnell, Jean Caron, Michael J. Meaney, and Yue Li
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Major depressive disorder (MDD) is the most prevalent mental disorder that constitutes a major public health problem. A tool for predicting the risk of MDD could assist with the early identification of MDD patients and targeted interventions to reduce the risk. We aimed to derive a risk prediction tool that can categorize the risk of MDD as well as discover biologically meaningful genetic variants. Data analyzed were from the fourth and fifth data collections of a longitudinal community-based cohort from Southwest Montreal, Canada, between 2015 and 2018. To account for high dimensional features, we adopted a latent topic model approach to infer a set of topical distributions over those studied predictors that characterize the underlying meta-phenotypes of the MDD cohort. MDD probability derived from 30 MDD meta-phenotypes demonstrated superior prediction accuracy to differentiate MDD cases and controls. Six latent MDD meta-phenotypes we inferred via a latent topic model were highly interpretable. We then explored potential genetic variants that were statistically associated with these MDD meta-phenotypes. The genetic heritability of MDD meta-phenotypes was 0.126 (SE = 0.316), compared to 0.000001 (SE = 0.297) for MDD diagnosis defined by the structured interviews. We discovered a list of significant MDD - related genes and pathways that were missed by MDD diagnosis. Our risk prediction model confers not only accurate MDD risk categorization but also meaningful associations with genetic predispositions that are linked to MDD subtypes. Our findings shed light on future research focusing on these identified genes and pathways for MDD subtypes.
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- 2022
- Full Text
- View/download PDF
241. Outcomes of importance to children and young adults with cerebral palsy, their parents and health professionals following lower limb orthopaedic surgery: A qualitative study to inform a Core Outcome Set
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Hajar Almoajil, Francine Toye, Helen Dawes, Jo Pierce, Andrew Meaney, Aziz Baklouti, Lara Poverini, Sally Hopewell, and Tim Theologis
- Subjects
cerebral palsy ,core outcome set ,interview ,surgery ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Introduction Although several outcomes are commonly measured to assess the effect of surgery for young people with cerebral palsy (CP), these are selected mainly by health professionals and researchers. Including the perspectives of a broader range of stakeholders is an essential step towards determining important outcomes for assessment. This qualitative study involves the development of a core outcome set (COS) for lower limb orthopaedic surgery for ambulant children with CP. Objective This study aimed to identify outcomes that matter to children and young people with CP, their parents and healthcare professionals following lower limb orthopaedic surgery. Methods Semi‐structured interviews were conducted with 10 healthcare professionals, 10 children and young people with CP and 8 parents. Interview data were analysed by content analysis supported by the International Classification of Functioning, Disability and Health (ICF‐CY) supplemented by thematic analysis. Findings Thirty‐one outcomes were identified in total, which were linked to eleven second‐level ICF‐CY categories. There were differences between stakeholder groups in preferences and expectations from surgical outcomes. Healthcare professionals and children with their parents identified 31 and 25 outcomes, respectively. Health outcomes valued by participants were lower limb alignment and symmetry, flexibility and muscle strength, mental health, fatigue, pain, function in life, mobility, participation, being independent, quality of life and adverse events. Compared to previous published trials, 10 new outcomes were revealed by this study. Conclusion The researchers identified outcomes that are important to all stakeholders following lower limb orthopaedic surgery for ambulant CP. Including these outcomes in future studies would promote patient‐centred care for children and young adults with CP. Findings will be used to inform an international Delphi survey and develop a COS in this field. Patient and Public Contribution This study was informed by an advisory group including a young adult with CP and a parent of a child with CP. This group engaged in the design of the study and the information material to support the interview (information sheet and interview topic guide).
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- 2022
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242. Developing guideline-based key performance indicators for recurrent miscarriage care: lessons from a multi-stage consensus process with a diverse stakeholder group
- Author
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Marita Hennessy, Laura Linehan, Rebecca Dennehy, Declan Devane, Rachel Rice, Sarah Meaney, and Keelin O’Donoghue
- Subjects
Early pregnancy loss ,Care quality ,Quality indicators ,Quality improvement ,Delphi technique ,Patient and public involvement ,Medicine ,Medicine (General) ,R5-920 - Abstract
Plain English summary Women/couples who have recurrent/repeated miscarriages should receive care that meets their needs, through agreed care pathways. This is often not the case. Key performance indicators (KPIs) are measures of specific elements of care (structures, processes and/or outcomes), which can help us to judge the quality of care given. In this paper, we describe how we worked with women and men with lived experience, doctors, nurses, managers, and others, to develop and agree on a list KPIs for recurrent miscarriage care in Ireland. We will use these to check what services are doing across the country and what could be done better. Participants filled out surveys and took part in meetings to vote on and agree on what KPIs were important to include. They also shared their views and experiences of taking part in this work. Together, we developed 110 KPIs for recurrent miscarriage care. These include measures of how care is structured, counselling and supports, investigations and treatments provided, and health-related outcomes. Participants’ valued the different views that people brought to discussions and what they learned. They suggested ways that the process could be made more participant-friendly. For example, being up-front about the time it would take, explaining medical terms more, and cutting down on the number of items to be rated in surveys. It is important and possible to develop KPIs with different groups, particularly those with lived experience. Learning from our study may help others who want to do similar projects, such as develop KPIs or guidelines for care.
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- 2022
- Full Text
- View/download PDF
243. Obesity and accelerated epigenetic aging in a high-risk cohort of children
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Laura Etzel, Waylon J. Hastings, Molly A. Hall, Christine M. Heim, Michael J. Meaney, Jennie G. Noll, Kieran J. O’Donnell, Irina Pokhvisneva, Emma J. Rose, Hannah M. C. Schreier, Chad E. Shenk, and Idan Shalev
- Subjects
Medicine ,Science - Abstract
Abstract New insights into mechanisms linking obesity to poor health outcomes suggest a role for cellular aging pathways, casting obesity as a disease of accelerated biological aging. Although obesity has been linked to accelerated epigenetic aging in middle-aged adults, the impact during childhood remains unclear. We tested the association between body mass index (BMI) and accelerated epigenetic aging in a cohort of high-risk children. Participants were children (N = 273, aged 8 to 14 years, 82% investigated for maltreatment) recruited to the Child Health Study, an ongoing prospective study of youth investigated for maltreatment and a comparison youth. BMI was measured as a continuous variable. Accelerated epigenetic aging of blood leukocytes was defined as the age-adjusted residuals of several established epigenetic aging clocks (Horvath, Hannum, GrimAge, PhenoAge) along with a newer algorithm, the DunedinPoAm, developed to quantify the pace-of-aging. Hypotheses were tested with generalized linear models. Higher age-and sex- adjusted z-scored BMI was significantly correlated with household income, blood cell counts, and three of the accelerated epigenetic aging measures: GrimAge (r = 0.31, P
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- 2022
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244. Inertial Confinement Fusion: How can we build a star on Earth?
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Meaney, Kevin, primary
- Published
- 2023
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245. Pre-Clinical Testing of Therapies for Traumatic Brain Injury
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DeWitt, Douglas S, Hawkins, Bridget E, Dixon, C Edward, Kochanek, Patrick M, Armstead, William, Bass, Cameron R, Bramlett, Helen M, Buki, Andras, Dietrich, W Dalton, Ferguson, Adam R, Hall, Edward D, Hayes, Ronald L, Hinds, Sidney R, LaPlaca, Michelle C, Long, Joseph B, Meaney, David F, Mondello, Stefania, Noble-Haeusslein, Linda J, Poloyac, Samuel M, Prough, Donald S, Robertson, Claudia S, Saatman, Kathryn E, Shultz, Sandy R, Shear, Deborah A, Smith, Douglas H, Valadka, Alex B, VandeVord, Pamela, and Zhang, Liying
- Subjects
Brain Disorders ,Traumatic Brain Injury (TBI) ,Traumatic Head and Spine Injury ,Physical Injury - Accidents and Adverse Effects ,Neurosciences ,Animals ,Brain Injuries ,Traumatic ,Disease Models ,Animal ,Humans ,guidelines ,pre-clinical ,traumatic brain injury ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long-term outcome in clinical trials. To develop recommendations and guidelines for pre-clinical testing of pharmacological or biological therapies for TBI, the Moody Project for Translational Traumatic Brain Injury Research hosted a symposium attended by investigators with extensive experience in pre-clinical TBI testing. The symposium participants discussed issues related to pre-clinical TBI testing including experimental models, therapy and outcome selection, study design, data analysis, and dissemination. Consensus recommendations included the creation of a manual of standard operating procedures with sufficiently detailed descriptions of modeling and outcome measurement procedures to permit replication. The importance of the selection of clinically relevant outcome variables, especially related to behavior testing, was noted. Considering the heterogeneous nature of human TBI, evidence of therapeutic efficacy in multiple, diverse (e.g., diffuse vs. focused) rodent models and a species with a gyrencephalic brain prior to clinical testing was encouraged. Basing drug doses, times, and routes of administration on pharmacokinetic and pharmacodynamic data in the test species was recommended. Symposium participants agreed that the publication of negative results would reduce costly and unnecessary duplication of unsuccessful experiments. Although some of the recommendations are more relevant to multi-center, multi-investigator collaborations, most are applicable to pre-clinical therapy testing in general. The goal of these consensus guidelines is to increase the likelihood that therapies that improve outcomes in pre-clinical studies will also improve outcomes in TBI patients.
- Published
- 2018
246. Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms
- Author
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Kee, Michelle Z.L., Teh, Ai Ling, Clappison, Andrew, Pokhvisneva, Irina, MacIssac, Julie L., Lin, David T.S., Ramadori, Katia E., Broekman, Birit F.P., Chen, Helen, Daniel, Mary Lourdes, Karnani, Neerja, Kobor, Michael S., Gluckman, Peter D., Chong, Yap Seng, Huang, Jonathan Y., and Meaney, Michael J.
- Published
- 2022
- Full Text
- View/download PDF
247. Education Standards for Pharmacists Providing Comprehensive Medication Management in Outpatient Nephrology Settings
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Hudson, Joanna Q., Maxson, Rebecca, Barreto, Erin F., Cho, Katherine, Condon, Amanda J., Goswami, Elizabeth, Moon, Jean, Mueller, Bruce A., Nolin, Thomas D., Nyman, Heather, Vilay, A. Mary, and Meaney, Calvin J.
- Published
- 2022
- Full Text
- View/download PDF
248. Cognitive flexibility in preschoolers: A role for the late frontal negativity (LFN)
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Abdul Rahman, Aishah, Tan, Hong-Kuang, Loo, Soh Teng, Abdul Malik, Adam Bin, Tan, Kok Hian, Gluckman, Peter D., Chong, Yap Seng, Meaney, Michael J., Qiu, Anqi, and Rifkin-Graboi, Anne
- Published
- 2022
- Full Text
- View/download PDF
249. Marginal Structural Models Using Calibrated Weights With SuperLearner: Application to Type II Diabetes Cohort.
- Author
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Sumeet Kalia, Olli Saarela, Tao Chen, Braden O'Neill, Christopher Meaney, Jessica L. Gronsbell, Ervin Sejdic, Michael D. Escobar, Babak Aliarzadeh, Rahim Moineddin, Conrad Pow, Frank M. Sullivan, and Michelle Greiver
- Published
- 2022
- Full Text
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250. Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta
- Author
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Reagan-Steiner, Sarah, Bhatnagar, Julu, Martines, Roosecelis B., Milligan, Nicholas S., Gisondo, Carly, Williams, Frank B., Lee, Elizabeth, Estetter, Lindsey, Bullock, Hannah, Goldsmith, Cynthia S., Fair, Pamela, Hand, Julie, Richardson, Gillian, Woodworth, Kate R., Oduyebo, Titilope, Galang, Romeo R., Phillips, Rebecca, Belyaeva, Elizaveta, Yin, Xiao-Ming, Meaney-Delman, Dana, Uyeki, Timothy M., Roberts, Drucilla J., and Zaki, Sherif R.
- Subjects
Infants -- Patient outcomes ,Perinatal infection -- Risk factors -- Complications and side effects -- Case studies ,Premature birth -- Case studies ,Health - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy is associated with severe maternal coronavirus disease (COVID-19) and preterm birth and may increase the risk for other complications of [...]
- Published
- 2022
- Full Text
- View/download PDF
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