Search

AIM: To examine the mechanism by which pericytes regulate peritoneal angiogenesis by observing the interaction between vascular pericytes and vascular endothelial cells. METHODS: Transforming growth factor-β1 （TGF-β1） was used to treat human microvascular pericytes（ HMPCs） for 24, 48 and 96 h, and the expression levels of angiopoietin 1（ Ang1） in HMPCs was detected by Western blot. The supernatant of TGF-β1-treated HMPCs was collected as conditioned medium （T-HMPC-CM）, and human peritoneal vascular endothelial cells （HPVECs） were treated with THMPC-CM to construct an indirect co-culture model. HMPCs were treated with TGF-β1 and seeded with HPVECs on matrigel to construct a direct co-culture model. The HMPCs without TGF-β1 treatment served as the negative control group, the Ang1-treated HPVECs served as the positive control group, and the Tie2 inhibitor-treated HPVECs served as the inhibitor group. The proliferation, migration and angiogenesis of HPVECs were detected by CCK-8 assay, wound healing assay, Transwell assay and Tube formation assay, and the co-localization of HPVECs and HMPCs was observed by cell membrane fluorescence probe staining. Total and phosphorylated Tie2 protein levels were detected by Western blot. RESULTS: The expression level of Ang1 in HMPCs was increased significantly after treated with TGF-β1 for 96 h. Compared with negative control group, T-HMPC-CM inhibited the migration and angiogenesis of HPVECs, and Tie2 was phosphorylated to stabilize the vascular state, which was similar to the effect of exogenous Ang1. After blocking the Ang1/Tie2 signaling pathway with a Tie2 inhibitor, these phenomena were reversed to some extent. CONCLUSION: The secretion of Ang1 in HMPCs is stimulated by TGF-β1, which activates the Tie2 signaling pathway in HPVECs, and then inhibits angiogenesis of HPVECs, thus maintaining peritoneal vascular stability. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Physical Education Institute / Shanghai Tiyu Xueyuan Xuebao is the property of Shanghai Physical Education Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electronic Components & Materials is the property of Electronic Components & Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：探究康复新液治疗湿疹皮炎类皮肤病的疗效。方法：选取于2021 年 3 月至 2023 年 6 月本院门诊收治 的 70 例湿疹皮炎类皮肤病患者，随机分为观察组（康复新液治疗）、对照组（常规治疗）各35人。结果：相比对照 组，观察组治疗效果高，且炎症反应、临床症状改善更明显（P < 0.05）。结论：康复新液治疗湿疹皮炎类皮肤病可 以获得更为理想的治疗效果。 [ABSTRACT FROM AUTHOR]

目的 分析专案护理在经皮冠状动脉介入治疗 (PCI)术前患者管理中的应用价值. 方法 将 2021 年 3 月至 2022 年 9 月于厦门市海沧医院介入导管室拟行 PCI 术的 110 例患者纳入研究, 使用简单随机法分入观察组 (55 例) 和对照组 (55 例). 2 组均接受常规术前管理, 观察组加用专案护理, 持续至 PCI 当日. 对比 2 组在干预前, PCI 术前 的心理弹性和应激反应变化, 并比较 2 组的术前准备情况及术后 24 h 并发症发生率. 结果 2 组在 PCI 术前的心理 弹性量表各维度评分均高于干预前, 2 组在 PCI 术前的心率均快于干预前, 以及收缩压, 舒张压和平均动脉压均高于 干预前;观察组的上述评分和指标均优于对照组, 结果均有统计学差异 (P 均 < 0. 05). 观察组的术前宣教, 术区评 估, 心理状态及医嘱执行合格率均高于对照组, 术后低血压, 尿潴留及腰部疼痛发生率均低于对照组 (P 均 < 0. 05); 观察组的服饰准备和饮食准备合格率, 以及拔管综合征发生率与对照组相比均无统计学差异 (P 均 > 0. 05). 结论 专案护理能够提高行 PCI 术前患者的心理弹性, 减轻其应激反应, 对于提高各项护理流程合格率及降低术后并发症 发生率也具有积极影响。 [ABSTRACT FROM AUTHOR]

Objective　 To investigate the intervention effect of cGAS inhibitor on cerebral ischemia reperfusion injury in mice， and to explore the related mechanism based on autophagy. Methods　 Eighteen C57BL/6 male mice were randomly divided into three groups： sham group， model group， and experimental group， with 6 in each. In the model group and experimental group， the middle cerebral artery occlusion model was prepared by suture method. Mice in the experimental group received intraperitoneal injection of 5 mg/kg cGAS inhibitor RU. 521 within 10 min before reperfusion. In the sham group， the middle cerebral artery was isolated but not blocked. After 6 h of reperfusion， the HE staining and Nissl staining was performed. The protein levels of cGAS， LC3B and Beclin-1 were detected by Western blotting. Apoptosis was detected by immunofluorescence. Results　 Compared with the sham group， the model group showed a reduced number of neurons and cellular consolidation. All the changes were alleviated after the administration of cGAS inhibitor. Compared with the sham group， cGAS， LC3B， Beclin-1 and apoptosis in the model group increased. Compared with the model group， cGAS， LC3B， Beclin-1 and apoptosis in the experimental group decreased （all P<0. 05). Conclusion　 cGAS inhibitor can effectively reduce cerebral ischemia reperfusion injury probably by regulating the expression of autophagy-related proteins. [ABSTRACT FROM AUTHOR]

Malicious face manipulation has a negative impact on social security and stability, and it is a very important issue to accurately detect video images after face tampering. In order to solve the problem of poor real-time performance of video manipulation detection model, this paper proposes a face manipulation video detection model based on ensemble learning dual-stream recurrent neural network, and introduces the voting mechanism in ensemble learning. The model first receives a small number of consecutive sequence frames, extracts spatial features through a convolutional neural network, and introduces central differential convolution to enhance tampering artifacts in the spatial domain. The model then differentiates consecutive sequence frames to enhance tampering artifacts in the temporal domain, while temporal feature extraction is performed through a convolutional neural network. Then, the model splices the dual-stream feature vectors in the spatial domain and the time domain, and performs feature extraction through a recurrent neural network. During the feature extraction process of the recurrent neural network, the frame-by-frame feature information is retained as the input of the subsequent auxiliary frame-level classifier, while the final output of the recurrent neural network is used as the input of the video-level discriminator. Finally, the model introduces the voting mechanism of the integrated model to integrate the outputs of multiple auxiliary frame-level discriminators and video-level discriminators, and introduces a weight hyperparameter γ to balance the importance of the auxiliary framelevel discriminator and video-level discriminator, helping the model to improve detection accuracy. On the FaceForensics++ dataset, the experimental results show that the proposed model improves the average accuracy by 0.4% and 1.0% compared with mainstream detection model. At the same time, the proposed model can only use fewer consecutive frames for manipulation detection, which improves the real-time performance of the model. [ABSTRACT FROM AUTHOR]

Data property rights are of great significance in the data foundational institution system. Data property rights are structurally separated into three rights, namely, the right of data resource possessing, the right of data processing and the right of data product managing. Existing theories are not practice-oriented, and the responsive way of right-granting can hardly fix the market failures as well. Based on the data factor circulation practice, two typical logics of data factor circulation were proposed, namely, architecture logic and market logic. Based on market logic, the data factor circulation value chain model was constructed. The generated way of right-granting could provide an explanation of the structural separation of data property rights. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Arid Zone Research / Ganhanqu Yanjiu is the property of Arid Zone Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of fluoxetine on depression-like behavior in chronic unpredictable mild stress (CUMS) model rats based on Toll-like receptor 4 (TLR4) /nuclear factor κB (NF-κB)/NOD-like receptor pyrin domain-associated protein 3 (NLRP3) inflammasome signaling pathway. Methods Eighteen SD rats were randomly divided into the control group, the model group and the fluoxetine group. Rats in the model group and the fluoxetine group were randomly given CUMS for 11 weeks to establish depression model. The fluoxetine group was treated with fluoxetine (10 mg· kg-1 ·d-1) through gastric perfusion from the 7th to the 11th week, and the other groups were given 1 mL of normal saline by gavage. Behavioral tests were conducted after the intervention. The levels of interleukin (IL)-1β and IL-18 in brain tissue were tested by enzyme-linked immunosorbent assay (ELISA). The expression of NLRP3 protein, apoptosis-associated specklike protein (ASC) and cysteine aspartate protease 1 (Caspase-1) protein in hippocampal CA3 area and cortical area regions were observed by immunofluorescence staining. Western blot assay was used to detect the protein expression levels of TLR4, NF- κB, NLRP3, Caspase-1 and activated cysteine aspartate protease 1 (cleaved Caspase-1) in brain tissue. Results Compared with the model group, the movement distance and standing times of rats in open field test were significantly increased, the movement distance in the elevated plus maze test was increased, and the dwell time in closed arms was decreased in the fluoxetine group. The contents of IL-1β and IL-18 in brain tissue were significantly decreased, and expression levels of TLR4, NF-κB, NLRP3, ASC, Caspase-1 and cleaved Caspase-1 proteins were also down-regulated in the fluoxetine group than those of the model group (P＜0.05). Conclusion Fluoxetine may improve depression-like behavior in CUMS rats by inhibiting TLR4/NF- κB/NLRP3 inflammasome signaling pathway and reducing the levels of inflammatory factors IL-1β and IL-18 in brain tissue. [ABSTRACT FROM AUTHOR]

[Objective] The study aims to investigate the effects of calcium on the growth and physiological characteristics of Camellia oleifera seedlings under aluminum stress, with a view to providing theoretical basis for revealing the physiological mechanism of calcium alleviation of aluminum stress in C. oleifera. [Method] The effects of different calcium concentrations (0, 0.5, 1.5, 3 and 5 mmol/L) applied under aluminum stress (4 mmol/L) on the growth, leaf photosynthesis, root osmoregulatory substances and antioxidant enzyme activities of C. oleifera seedlings were determined through a pot experiment. [Result] Aluminum stress inhibited the growth of C. oleifera seedlings significantly, and the application of 3 mmol/L calcium significantly alleviated the inhibition of aluminum growth in C. oleifera, and the plant dry weight increased by 40.58%. For photosynthetic parameters, aluminum stress reduced chlorophyll a, chlorophyll b, carotenoids and total chlorophyll contents of C. oleifera leaves. Net photosynthetic rate (Pn), stomatal conductance (Gs) and transpiration rate (Tr) decreased by 32.28%, 51.02% and 53.91%, respectively, compared with those under CK treatment, while intercellular CO2 concentration (Ci) increased by 20%. The addition of appropriate amount of calcium (1.5-3 mmol/L) significantly increased the photosynthetic pigment content, Pn, Gs and Tr, and decreased Ci of leaves. Compared with aluminum stress, calcium application could reduce the accumulation of root free proline and increased the soluble sugar content effectively. Under aluminum stress, the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) in the roots and ascorbate peroxidase (APX) in the leaves were significantly reduced. The plasma membrane permeability and malondialdehyde (MDA) content in the roots were significantly increased. Calcium application significantly enhanced antioxidant enzyme activities. POD and AXP activities were highest when the calcium concentration was 1.5 mmol/L, which were 35.13 and 234.11 U/g, respectively; and SOD and CAT activities were highest when the calcium concentration was 3.0 mmol/L, which were 533.20 and 48.42 U/g, respectively. Meanwhile, the addition of appropriate concentration of calcium (1.5-3 mmol/L) significantly reduced root plasma membrane permeability and MDA content, which were 19.52%-31.40% and 23.32%-27.86% lower than those under aluminum stress treatment, respectively. [Conclusion] Calcium at moderate concentrations (1.5-3 mmol/L) significantly improved photosynthetic capacity and antioxidant enzyme activity of C. oleifera leaves, reduced reactive oxygen stress and production of membrane lipid peroxidation products, and alleviated the toxic effects of aluminum stress on C. oleifera seedlings by regulating osmotic substances. However, when the calcium concentration reached 5 mmol/L, it inhibited the growth of C. oleifera seedlings. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Plastics Science & Technology / Suliao Ke-Ji is the property of Plastics Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Library & Information Science in Agriculture is the property of Editorial Board of Journal of Library & Information Science in Agriculture and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering of Oil & Gas / Shi You Yu Tian Ran Qi Hua Gong is the property of PetroChina Southwest Oil & Gas Field Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Southern Energy Construction is the property of Southern Energy Construction Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Piezoelectrics & Acoustooptics is the property of Piezoelectric & Acoustooptic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Jilin University (Medicine Edition) is the property of Jilin University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nonferrous Metals (Mineral Processing Section) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Remote Sensing for Natural Resources is the property of Remote Sensing for Natural Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

回顾性分析1例在福建医科大学附属龙岩第一医院内分泌科住院的2型糖尿病合并动 脉粥样硬化性心血管疾病（ASCVD）患者应用司美格鲁肽治疗后血糖、血压得到平稳控制，同时体重 进一步下降，并针对本病例进行文献复习。患者为68岁男性，因“口干、多饮12年，胸闷、胸痛伴血糖 控制不佳 1个月”入院，入院后根据既往病史、体征和实验室检查诊断为 2型糖尿病合并 ASCVD。患 者予持续皮下胰岛素输注后采用胰高糖素样肽‑1受体激动剂（GLP‑1RA）利拉鲁肽治疗，但患者在逐 渐增量至每天1.8 mg注射后维持8个月体重下降不明显，改为司美格鲁肽后体重得到进一步下降，未 再发生发作性胸闷、胸痛，并且血糖和血压也得到平稳控制。司美格鲁肽是一种新型 GLP‑1RA周制 剂，对于 2型糖尿病合并 ASCVD 的患者除了能降糖外也能发挥积极的抗动脉粥样硬化和降压、减重 的效果。 [ABSTRACT FROM AUTHOR]