151. Cellular and molecular mechanisms of viral infection in the human placenta
- Author
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Luis Didier González-García, Arturo Flores-Pliego, Veronica Zaga-Clavellina, Alma Herrera-Salazar, Edgar Ricardo Vázquez-Martínez, Addy Cecilia Helguera-Repetto, Moisés León-Juárez, Julio García-Cordero, Enrique Reyes-Muñoz, and Macario Martínez-Castillo
- Subjects
0301 basic medicine ,Microbiology (medical) ,Placenta ,Viral pathogenesis ,Syncytiotrophoblasts ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Viral entry ,medicine ,Humans ,Immunology and Allergy ,viruses ,Pregnancy Complications, Infectious ,reproductive and urinary physiology ,Fetus ,viral pathogenesis ,General Immunology and Microbiology ,General Medicine ,medicine.disease ,Virology ,trophoblasts ,Haematopoiesis ,030104 developmental biology ,Infectious Diseases ,medicine.anatomical_structure ,Virus Diseases ,030220 oncology & carcinogenesis ,embryonic structures ,Immunology ,maternal–fetal interface ,Gestation ,Female ,viral entry ,Minireview ,vertical infection - Abstract
The placenta is a highly specialized organ that is formed during human gestation for conferring protection and generating an optimal microenvironment to maintain the equilibrium between immunological and biochemical factors for fetal development. Diverse pathogens, including viruses, can infect several cellular components of the placenta, such as trophoblasts, syncytiotrophoblasts and other hematopoietic cells. Viral infections during pregnancy have been associated with fetal malformation and pregnancy complications such as preterm labor. In this minireview, we describe the most recent findings regarding virus–host interactions at the placental interface and investigate the mechanisms through which viruses may access trophoblasts and the pathogenic processes involved in viral dissemination at the maternal–fetal interface., One current overview about viral entry and dissemination mechanism at the maternal–fetal interface.
- Published
- 2017