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Abstract Background Air in the venous system may cause vascular air embolism, which is a potentially life-threatening event. The presence of air in venous system after basilar skull fracture is very rare. Case presentation A 77-year-old man fell from a truck bed and suffered head and neck trauma. On hospital arrival, his consciousness was clear and his vital signs were stable. His chief complaint was pain in the back of his head and neck. Head CT showed traumatic subarachnoid hemorrhage in the right frontal area and basilar skull fracture of the occipital bone. Whole body CT showed pneumocephalus and air in the jugular vein and right ventricle. The patient was placed in the supine position in a state of absolute rest to prevent vascular air embolism and was treated conservatively. On hospital day 3, CT was reperformed, revealing disappearance of air in the right ventricle and decreased air in the veins of the head and neck. On hospital day 4, the air in the veins disappeared completely on CT. He did not experience vascular air embolism after increasing of his activity level (e.g., raising his head on hospital day 3 and standing and walking alone on day 5). He was discharged 34 days after admission without sequelae. Conclusions Head trauma patients with basilar skull fracture might develop vascular air embolism if physicians fail to detect air in the venous system on hospital arrival. A high degree of suspicion regarding air in venous system or heart is required when patients present with such injuries.

Abstract Background Emphysematous pyelonephritis (EPN) with gas in the inferior vena cava (IVC) is a rare presentation and to our knowledge, this is the first case report in the urologic literature. Case presentation A 35-Year-old obese diabetic Hispanic female presented to the emergency room with a clinical picture of septic shock. Prompt computerized tomography scan revealed EPN with gas throughout the right renal parenchyma and extending to the right renal vein, IVC, and pulmonary artery. She died before surgical intervention Conclusion This case demonstrates that patients presenting with severe EPN have a high mortality risk and providers should acknowledge that septic shock, endogenous air emboli, or a combination of both could result in cardiovascular collapse and sudden death.

Background: Endobronchial electrocautery is a common and safe therapeutic endoscopic treatment for malignant airway obstruction. Cerebral arterial air embolism (CAAE) is a rare but potentially fatal complication of endobronchial electrocautery.Case Presentation: We present the first case of cerebral arterial air embolism after endobronchial electrocautery. A 56-year-old male with a pulmonary tumour in the right upper lobe received repeated endobronchial electrocautery. During the procedure, he experienced unresponsiveness, hypoxemia and bradycardia, and he developed tetraplegia. Brain computed tomography showed several cerebral arterial air emboli with low-density spots in the right frontal lobe. He received hyperbaric oxygen therapy with almost full recovery, except for residual left-sided weakness.Conclusions: General physicians should realize that CAAE may be a possible complication of endobronchial electrocautery. Several measures, including avoiding positive pressure, lowering ventilatory pressures if possible, avoiding advancing the bronchoscope to occlude the bronchus and using the non-contact technique, should be used to prevent this devastating complication. [ABSTRACT FROM AUTHOR]

An air embolism is induced by intravascular bubbles that block the blood flow in vessels, which causes a high risk of pulmonary hypertension and myocardial and cerebral infarction. However, it is still unclear how a moving bubble is stopped in the blood flow to form an air embolism in small vessels. In this work, microfluidic experiments, in vivo and in vitro, are performed in small vessels, where bubbles are seen to deform and stop gradually in the flow. A clot is always found to originate at the tail of a moving bubble, which is attributed to the special flow field around the bubble. As the clot grows, it breaks the lubrication film between the bubble and the channel wall; thus, the friction force is increased to stop the bubble. This study illustrates the stopping process of elongated bubbles in small vessels and brings insight into the formation of air embolism. [ABSTRACT FROM AUTHOR]

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Background: Transpulmonary passage of air emboli can lead to fatal brain‐ and myocardial infarctions. We studied whether pigs with open chest and pericardium had a greater transpulmonary passage of venous air emboli than pigs with closed thorax. Methods: We allocated pigs with verified closed foramen ovale to venous air infusion with either open chest with sternotomy and opening of the pleura and pericardium (n = 8) or closed thorax (n = 16). All pigs received a five‐hour intravenous infusion of ambient air, starting at 4‐6 mL/kg/h and increased by 2 mL/kg/h each hour. We assessed transpulmonary air passage by transesophageal M‐mode echocardiography and present the results as median with inter‐quartile range (IQR). Results: Transpulmonary air passage occurred in all pigs with open chest and pericardium and in nine pigs with closed thorax (56%). Compared to pigs with closed thorax, pigs with open chest and pericardium had a shorter to air passage (10 minutes (5‐16) vs. 120 minutes (44‐212), P <.0001), a smaller volume of infused air at the time of transpulmonary passage (12 mL (10‐23) vs.170 mL (107‐494), P <.0001), shorter time to death (122 minutes (48‐185) vs 263 minutes (248‐300, P =.0005) and a smaller volume of infused air at the time of death (264 mL (53‐466) vs 727 mL (564‐968), P =.001). In pigs with open chest and, infused air and time to death correlated strongly (r = 0.95, P =.001). Conclusion: Open chest and pericardium facilitated the transpulmonary passage of intravenously infused air in pigs. [ABSTRACT FROM AUTHOR]

In this study, a magnetic sensing approach is proposed for detecting air bubbles in intravenous fluids (IVs). To the author's knowledge, this is the first paper to apply magnetic sensing technology for the detection of air bubbles in an IV fluid. The approach is based on a compact, portable, and cost-effective sensor prototype that utilizes an LC resonator and a microcontroller. To validate the detecting system, an IV fluid containing air bubbles is passed through a medical tube, and the tube is passed over a planar coil. The magnetic interaction during the flow of the IV fluid with air bubbles is monitored and logging in real time. Air bubbles of 38, 44, 63 and 75 mm3 in IV fluid were successfully detected by the proposed sensing approach. Besides, the detection system is able to determine the flow direction, which is not encountered in alternatives such as capacitive sensing. The measurements from the established test setup, an average air bubble of 28 mm3 causes an inductance variation of approximately 2.8 nH. [Display omitted] • The proposed inductive sensing tech. detects the flow direction as well as the air bubbles. • One sensor, two detections: 1) Air bubbles and 2) Flow direction. • No need for ready-made instruments, easy integration into health devices. • Simple architecture enables wide application feasibility. • Cost-effective compared to alternatives, ideal for healthcare facilities. [ABSTRACT FROM AUTHOR]

Introduction: In the present era, percutaneous nephrolithotomy (PCNL) is the standard treatment for large (>2 cm) renal or staghorn renal stones. Both air and iodinated contrast has been used to opacify the pelvicalyceal system (PCS) before the dilatation of the tract. There are rare reports of air embolism following air pyelogram on mere presumptions. Materials and Methods: This is a prospective observational study. A total of 164 patients underwent PCNL in which air was used to opacify the PCS by placing a ureteric catheter for initial access. Results: None of our patients developed any complication during the procedure or in the postoperative period, which could be attributed to air embolism. Conclusions: The present study ascertains that using air for opacification of PCS for initial puncture access is a safe and acceptable alternative to iodinated contrast.

Off-pump coronary artery bypass grafting (OPCAB), although devoid of the morbidity associated with cardiopulmonary bypass (CPB), has its own technical difficulties. Achieving optimum tissue stabilization on a beating heart along with hemodynamic fragility due to extreme positioning also complicates the anesthetic management. In addition, it is difficult to obtain a clear surgical field in the presence of arteriotomy. The use of catheter-directed high-flow gas blower (mister blower) helps achieve a clear surgical field to a great extent. However, there have been reported cases of arterial and pulmonary embolism caused by these high-flow gas blowers. The present case reports a case of massive venous air embolism caused by the use of mister blower.

An otherwise healthy man in his 40s recently diagnosed with esophageal adenocarcinoma sustained an air embolism during the insertion of a mediport under mild sedation that was noted while using pulse fluoroscopy to ensure good visibility of adequate placement of the catheter tip. Pulse fluoroscopy allowed the early detection of a potentially catastrophic situation caused by air in the right heart and main pulmonary artery, thus allowing prompt correction of the mistake that had allowed the air embolism to occur. Pulse fluoroscopy eliminates or greatly reduces the blurred vision of highly mobile objects and enhances the view of low contrast objects thus enhancing imaging quality. [ABSTRACT FROM AUTHOR]

[West J Emerg Med. 2014;15(4):352–353.]

Abstract This report highlights the need for a coordinated approach to substantial arterial air embolization, considering the high risk of neurologic injury. Appropriate management may involve systemic hypothermia, hyperoxia, and retrograde cerebral perfusion.

Coronary artery air embolization is a rare event leading to catastrophic hemodynamic compromise within seconds after introduction of air within the coronary arteries. The management of massive air embolism should be extremely quick so as to prevent cardiac compromise. In this report, we present a case of massive air embolism in the left anterior descending artery during coronary angiography in a 47-year-old female with a history of smoking and hyperlipidemia, who was admitted due to typical exertional chest pain despite analgesic administration. Coronary angiography was performed for the patient which revealed huge aneurysm of the left main artery and total occlusion of LAD artery and air embolism in the LAD and left main artery. Blood flow was attained by passing a catheter through the LAD occlusion. The preexisting coronary artery disease in this patient has led to success in the management of massive coronary emboli. Massive coronary artery emboli are life threatening and require urgent management, however, some patients might benefit from coexisting coronary pathologies as in this case.

Cerebral air embolism is a rare, potentially catastrophic iatrogenic complication of central venous catheter removal. Cerebral air embolism can lead to serious neurological sequelae, resulting from cerebral infarction. Early radiological diagnosis of cerebral air embolism is critical for emergent hyperbaric oxygen treatment. In this study, we report the case of a 68-year-old man who developed cerebral air embolism after the removal of a central venous catheter that was immediately diagnosed using brain CT and brain diffusion-weighted imaging.

Purpose Complete removal of air bubbles from balloons for neurovascular angioplasty is cumbersome. We compared the preparation difficulty, air removal efficiency, and air collection pattern of six different balloon catheter preparation methods to propose a better preparation method for both initial and second balloon uses, especially for small-profile angioplasty balloon catheters.Materials and Methods A total of 18 neurovascular angioplasty balloon catheters with nominal diameters of 2 mm were prepared to test six different preparation methods: the instruction for use method (method A), simplified method using a syringe (method B) and four newly devised preparation methods using inflating devices (methods C–F). Serial radiographs were obtained while the balloons were gradually inflated. We measured the time for each preparation and the bubble number, analyzed their distribution in the balloon, and calculated the contrast filling ratio (contrast filling area/total balloon area) for initial and second ballooning. The whole process was repeated three times. Results The preparation time varied widely (11.5 seconds [method D] to 73.3 seconds [method A]). On initial inflation, the contrast filling ratio at 8 atm was the highest (100%) with methods A and F. On second inflation, the ratio was again highest with method A (99.5%), followed by method F (99.2%). Initial ballooning tended to show a uniform pattern of single bubble in the distal segment of the balloon; in contrast, second ballooning showed varying patterns in which the bubbles were multiple and randomly distributed. Conclusion None of the six methods were able to completely exclude air bubbles from the balloon catheters including the second ballooning; however, the method of repeating aspiration with high-volume inflating device (method F) could be a practical option considering the simplicity and efficiency of preparation.

Coronary arterial air embolism is an extremely rare but readily recognizable condition on computed tomography (CT) that may complicate a lung biopsy. We present an incidence of symptomatic air embolism into the right coronary artery during a percutaneous CT-guided lung biopsy that was successfully recognized during the procedure and managed accordingly. An active search for this complication should be made when the patient deteriorates on table and the usual complications (pneumothorax, vasovagal shock, etc.) are ruled out, as immediate resuscitative measures could be life-saving.

Abstract Background Intravascular air embolism (AE) is a preventable but potentially catastrophic complication caused by intravenous tubing, trauma, and diagnostic and surgical procedures. The potentially fatal risks of arterial AE are well-known, and emerging evidence demonstrates impact of venous AEs on inflammatory response and coagulation factors. A novel FDA-approved in-line air detection and purging system was used to detect and remove air caused by administering a rapid fluid bolus during surgery. Methods A prospective, randomized, case series was conducted. Subjects were observed using standard monitors, including transesophageal echocardiography (TEE) in the operating room. After general anesthesia was induced, an introducer and pulmonary artery catheter was inserted in the right internal jugular to administer fluids and monitor cardiac pressures. Six patients undergoing cardiac surgery were studied. Each patient received four randomized fluid boluses: two with the in-line air purging device, two without. For each bolus, a bulb infuser was squeezed three times (10–15 mL) over 5 s. The TEE was positioned in the mid-esophageal right atrium (RA) to quantify peak air clearance, and images were video recorded throughout each bolus. Air was quantified using optical densitometry (OD) from images demonstrating maximal air in the RA. Results All subjects demonstrated significantly lower air burden when the air reduction device was used (p = 0.004), and the average time to clear 90% of air was also lower, 3.7 ± 1.2 s vs. 5.3 ± 1.3 s (p

Background: Although a well-recognized phenomenon of the tentorium and posterior fossa, the trigeminocardiac reflex (TCR) has been rarely reported during surgery involving the posterior falx cerebri. Case Description: We present the case of a 63-year-old woman who underwent repeat resection of an atypical parasagittal meningioma involving the posterior falx. During resection, TCR was repeatedly elicited during manipulation and coagulation of the falx. Air embolism and cardiac etiologies were initially considered while TCR was not suspected, given the location. Ultimately, TCR was recognized when asystole self-resolved upon cessation of stimulus and due to its reproducibility. Conclusion: Awareness by the anesthesiologist and neurosurgeon of the possibility of TCR during falcine procedures can help with rapid identification to avoid a potentially catastrophic outcome. [ABSTRACT FROM AUTHOR]

Air embolism is characterized by the presence of gas in the bloodstream. It can be caused by diving and as a complication of different diagnostic and / or therapeutic procedures. In some cases it has serious medical complications, including death. The clinical impact depends on the volume of air within the cardiovascular system, the air intake velocity and its location. In the most serious cases, diagnosis and treatment must be immediate. Hyperbaric oxygen therapy allows immediate etiological treatment by rapidly reducing the size of air bubbles and dissolving them. [ABSTRACT FROM AUTHOR]

Introduction: Air embolism is a complication that is rarely documented in Neonatal Intensive Care Units. It is secondary to alveolar rupture, placement of umbilical catheters, chest compressions, or medication administration. With the implementation of Point of Care Ultrasound (POCUS) programs, more cases have been identified. Clinical case: Preterm newborn of 30 weeks of gestation, with two ultrasound evaluations: the first at the time of admission because he presented hypotension, determining that he had transitional circulation with adequate biventricular function and low cardiac output. The second study was carried out because the newborn collapsed, after manipulation of umbilical catheters; observing a hyperechoic image with acoustic shadow "in a comet's tail" in the right ventricular outflow tract, which generated obstruction. Tamponade, pneumothorax and pleural effusion were ruled out. Despite intensive management, the patient developed severe metabolic acidosis, hyperlactatemia and hypotension refractory, and subsequently died. Conclusion: Air embolism is a serious complication, which can go unnoticed and may be life threatening. Ultrasound seems to be a good tool for its detection, which should help to establish a timely management. [ABSTRACT FROM AUTHOR]

Objective: Venous air embolism as a complication of contrast media administration from power injection systems in CT is found to occur in 7%–55% of patients, impacting patient safety, diagnostic image quality, workflow efficiency, and patient and radiographer satisfaction. This study reviews the challenges associated with reactive air management approaches employed on contemporary systems, proposes a novel air management approach using proactive methods, and compares the impact of reactive and proactive approaches on injected air volumes under simulated clinical use. Methods: Injected air volumes from three power injection systems were measured under simulated clinical use via custom air trap fixture. Two of the systems employed reactive air management approaches, while a new system implemented the proposed proactive air management approach. Results: The proactive system injected significantly less air (average of 0.005 mL ± 0.006 mL with a maximum of 0.017 mL) when compared to two systems with reactive approaches (averages of 0.130 mL ± 0.082 mL and 0.106 mL ± 0.094 mL with maximums of 0.259 mL and 0.311 mL, respectively) (p < 0.05). CT images were taken of static and dynamic 0.1 mL air bubbles inside of a vascular phantom, both of which were clearly visible. Additionally, the dynamic bubble was shown to introduce image artifacts similar to those observed clinically. Conclusion: Comparison of the injected air volumes show that a system with a proactive air management approach injected significantly less air compared to tested systems employing reactive approaches. Significance: The results indicate that the use of a proactive approach could significantly reduce the prevalence of observable, and potentially artifact-inducing, venous air embolism in contrast-enhanced CT procedures. [ABSTRACT FROM AUTHOR]

Excessive amounts of air can enter the lungs and cause air embolism (AE)-induced acute lung injury (ALI). Pulmonary AE can occur during diving, aviation, and iatrogenic invasive procedures. AE-induced lung injury presents with severe hypoxia, pulmonary hypertension, microvascular hyper-permeability, and severe inflammatory responses. Pulmonary AE-induced ALI is a serious complication resulting in significant morbidity and mortality. Surfactant is abundant in the lungs and its function is to lower surface tension. Earlier studies have explored the beneficial effects of surfactant in ALI; however, none have investigated the role of surfactant in pulmonary AE-induced ALI. Therefore, we conducted this study to determine the effects of surfactant in pulmonary AE-induced ALI. Isolated-perfused rat lungs were used as a model of pulmonary AE. The animals were divided into four groups (n = 6 per group): sham, air embolism (AE), AE + surfactant (0.5 mg/kg), and AE+ surfactant (1 mg/kg). Surfactant pretreatment was administered before the induction of pulmonary AE. Pulmonary AE was induced by the infusion of 0.7 cc air through a pulmonary artery catheter. After induction of air, pulmonary AE was presented with pulmonary edema, pulmonary microvascular hyper-permeability, and lung inflammation with neutrophilic sequestration. Activation of NF-κB was observed, along with increased expression of pro-inflammatory cytokines, and Na-K-Cl cotransporter isoform 1 (NKCC1). Surfactant suppressed the activation of NF-κB and decreased the expression of pro-inflammatory cytokines and NKCC1, thereby attenuating AE-induced lung injury. Therefore, AE-induced ALI presented with pulmonary edema, microvascular hyper-permeability, and lung inflammation. Surfactant suppressed the expressions of NF-κB, pro-inflammatory cytokines, and NKCC1, thereby attenuating AE-induced lung injury. [ABSTRACT FROM AUTHOR]

Cerebral air embolism is a rare and fatal complication of computed tomography-guided transthoracic lung biopsy. Lesions with pulmonary vein involvement--especially cavitary lesions--require particular care during procedures performed with a guided needle. Only 2 ml of an air embolism reaching the cerebral arteries is fatal, and a 1-ml cardiac air embolism can be fatal. Hyperbaric oxygen therapy should be started immediately to reduce mortality and ensure recovery among patients who develop unconsciousness and extremity paralysis during or after the procedure including when diagnosed with cranial CT imaging. Hyperbaric oxygen therapy has been reported to reduce mortality by up to 7% and reduces neurological deficits after 48 hours--even in delayed cases. Thus, transthoracic lung biopsy is important for the diagnosis of peripheral lung masses. Here, we present a rare complication after this procedure. Our goal here was to contribute to early diagnosis and treatment by creating awareness. [ABSTRACT FROM AUTHOR]

Vaginal injuries with clinical complications apart from local bleeding following sexual intercourse are thought to be rare events that have recently fostered a discussion on the topic. We report a case of a vaginal laceration resulting in death caused by air embolism in a non-pregnant woman during consensual sexual intercourse with digital and penile penetration. Hysterectomy and a preexisting vaginal injury were additional risk factors present in this case. Besides case history and autopsy findings, histological examination of the vaginal lesion and postmortem computer tomography (PMCT) helped in diagnosing the cause of death and underlying pathophysiological mechanisms. [ABSTRACT FROM AUTHOR]

Background: Air embolism is a known risk during thoracic endovascular aortic repair (TEVAR) and is associated with an incomplete deairing of the delivery system despite the saline lavage recommended by the instructions for use (IFU). As the delivery systems are identical and residual air remains frequently in the abdominal aortic aneurysm sac, endovascular aortic repair (EVAR) can be used to examine the effectiveness of deairing maneuvers. We aimed to evaluate whether increasing the flush volume can result in a more complete deairing., Methods: Patients undergoing EVAR were randomly assigned according to flushing volume (Group A, 1× IFU; Group B, 4× IFU). The Terumo Aortic Anaconda and Treo and Cook Zenith Alpha Abdominal stent grafts were randomly implanted in equal distribution (10-10-10). The quantity of air trapped in the aneurysm sac was measured using a pre-discharge computed tomography angiography (CTA). Thirty patients were enrolled and equally distributed between the two groups, with no differences observed in any demographic or anatomical factors., Results: The presence of air was less frequent in Group A compared to that in Group B [7 (47%) vs. 13 (87%), p  = .02], and the air volume was less in Group A compared to that in Group B (103.5 ± 210.4 vs. 175.5 ± 175.0 mm 3 , p  = .04). Additionally, the volume of trapped air was higher with the Anaconda graft type ( p  = .025)., Discussion: These findings suggest that increased flushing volume is associated with a higher amount of trapped air; thus, following the IFU might be associated with a reduced risk of air embolization. Furthermore, significant differences were identified between devices in terms of the amount of trapped air., Clinical Trial Registration: [NCT04909190], [ClinicalTrials.gov]., Competing Interests: ZS is a speaker, trainer, and proctor for Cook Medical. CC-N is a speaker, trainer, and proctor for Terumo Aortic and Cook Medical. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Szentiványi, Borzsák, Vecsey-Nagy, Süvegh, Hüttl, Fontanini, Szeberin and Csobay-Novák.)

Hydrogen peroxide (H2O2) is a commonly used chemical agent in orthopaedic practice for antisepsis, haemostasis and preparation of bone bed for cementation. However, the associated risks of H2O2 usage are not widely known. We report a case of suspected air embolism after use of H2O2 during drainage of a septic arthritis of the shoulder. Upon our literature review, we were able to demonstrate H2O2 to be beneficial in antisepsis and care of chronic wounds. However, it has not been proven to be superior to other antiseptics commonly used in orthopaedic surgery. Regarding its use in cementation, there is evidence to show it is more effective than saline however, the use of pulsatile lavage appears to be the most important factor affecting the quality of cementation. H2O2 has not been shown to be helpful with haemostasis. Prior to the use of H2O2, one should be cautious and understand its associated risks and precautions. [ABSTRACT FROM AUTHOR]

Background: Air embolism can cause the following catastrophic complications that must be avoided: cardiogenic shock (from right heart failure), obstructive shock, myocardial infarction, stroke, RVOT obstructions, and pulmonary embolism. Currently there is a paucity of data on Impella RP use in rare causes of acute right ventricle (RV) failure, especially if caused by air embolism.Case Report: We report a case of a patient with acute RV failure due to air embolism who recovered from temporary use of Impella RP.Discussion: This case highlights the utility of right-sided mechanical support (MCS) devices for acute RV failure. [ABSTRACT FROM AUTHOR]

Air embolism is a rare, fatal complication of computed tomography (CT)‐guided transthoracic needle biopsy (TTNB) of the lung. Here, we report a patient who developed an air embolism after CT‐guided TTNB, which led to ST‐elevation myocardial infarction and acute cerebral ischemia. The patient recovered completely without critical sequelae and was diagnosed with adenocarcinoma harboring activating epidermal growth factor receptor (EGFR) mutation. The patient responded to subsequent treatment with gefitinib. Key points: Signficant findings of the study: Air embolism is a rare, fatal complication of CT‐guided transthoracic lung biopsy. Only a few cases have been previously reported where myocardial and cerebral infarction occurred after TTNB, demonstrated not only on CT scan, but also electrocardiogram and electroencephalogram. What this study adds: Detection of driver gene mutation is crucial for planning lung cancer treatment. Despite the need for tissue biopsy, air embolism propagation to vital organs could result in severe end‐organ damage and multidisciplinary approaches are needed to improve initial outcomes. [ABSTRACT FROM AUTHOR]

[West J Emerg Med. 2012;13(1):111–113.]

BackgroundPrevious investigations reveal that BTP2, a store-operated calcium channel blocker, has protective and anti-inflammatory properties in multiple inflammatory diseases. This study investigates whether BTP2 can protect against decompression sickness (DCS) in a rat model.MethodsBTP2 (2 mg/kg) was administered to male Sprague–Dawley rats 30 min before subjecting them to hyperbaric pressure. Control rats were not treated. After decompression, signs of DCS were examined, and samples of bronchoalveolar lavage fluid and lung tissue were obtained for evaluation.ResultsThe incidence and mortality of DCS were decreased significantly in rats treated with BTP2 compared to those treated with dimethyl sulfoxide. BTP2 significantly attenuated DCS-induced lung edema, histological evidence of lung inflammation, necroptosis, and apoptosis, while it decreased levels of tumor necrosis factor alpha, interleukin-6, and cytokine-induced neutrophil chemoattractant-1 in bronchoalveolar lavage fluid. In addition, BTP2 reduced the expression of nuclear factor of activated T cells and early growth response protein 3 in lung tissue. BTP2 also significantly increased the levels of inhibitor kappa B alpha and suppressed the levels of nuclear factor kappa B in lung tissue.ConclusionThe results suggest that BTP2 may has potential as a prophylactic therapy to attenuate DCS-induced injury.

Hava embolisi nadir görülen ancak yüksek morbidite ve mortalite oranları ile iyi tanınması gereken bir klinik durumdur. Hava embolisi için sensitif erken tanı yöntemleri bulunmaktadır, ancak her zaman bu yöntemlere ulaşmak kolay olmamaktadır. Venöz hava embolisinin saptanması ile birlikte, havanın hızla aspire edilmesi ve yandaş tedavilerin uygulanması ile mortalite ve morbiditede azalma sağlanabilmektedir. Önemli olan erken dönemde embolinin ortaya çıkarabileceği sorunların tanınması ve önlenmeye çalışılmasıdır. Venöz hava embolilerinde, aspire edilen hava miktarı ile mortalite ve morbidite doğru orantılıdır. Burada en önemli yaklaşım hava embolisi gelişimini engellemeye çalışmak ve her zaman gelişebileceğini akılda tutarak olası durumlarda erken tanı koymaktır. Bu olgu sunumunda 51 yaşında kadın hastada postoperatif dönemde hava embolisi tanısı konması ve uygulanan tedaviler sunulmuştur.

Though rare, air embolism as a serious complication may occur in patients undergoing coronary angiography and aortography. If gas embolism is diagnosed, hyperbaric oxygen therapy should be initiated immediately after the air source is cutoff and vital functions are stabilized. In this case presentation, a patient went into a coma after a massive iatrogenic cerebral air embolism that developed during the aortography procedure. The patient was discharged with hyperbaric oxygen therapy without any sequelae. [ABSTRACT FROM AUTHOR]