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157. Additional file 1 of tiRNA-Val promotes angiogenesis via Sirt1–Hif-1α axis in mice with diabetic retinopathy

Author

Xu, Yan, Zou, Haidong, Ding, Qi, Zou, Yuelan, Tang, Chun, Lu, Yuyu, and Xu, Xun

Abstract

Additional file 1. Supplementary figures. (a) 1% agarose gel electrophoresis were used to the analysis RNA integrity and the sample with 28S/18S = 1.5–2.0 were chosen for the following research. DR: diabetic retinopathy. (b) From the Northern result of tRNA-Val, we did not find the difference of precursor tRNA. Precursor tRNA containing 5′ leader sequence, 3′ trailer sequence and intron was not considered in this study. High, high glucose.

Published
2022
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159. Clinical characteristics and risk factors of myopic retinoschisis in an elderly high myopia population.

Author

Li, Menghan, Yu, Jiayi, Chen, Qiuying, Zhou, Hao, Zou, Haidong, He, Jiangnan, Zhu, Jianfeng, Fan, Ying, and Xu, Xun

Subjects
MYOPIA, OPTICAL coherence tomography, OLDER people, MACULAR degeneration, ODDS ratio
Abstract

Purpose: To investigate the clinical characteristics, internal correlations and risk factors for different locations of retinoschisis (RS) in an elderly high myopia (HM) population. Methods: A total of 448 eyes (304 participants) were analysed and classified into no retinoschisis (no‐RS), paravascular retinoschisis (PVRS), peripapillary retinoschisis (PPRS) and macular retinoschisis (MRS) groups. Each participant underwent comprehensive ophthalmic examinations, and posterior scleral height (PSH) was measured in swept‐source optical coherence tomography images. PSH, vitreoretinal interface abnormities and myopic atrophy maculopathy (MAM) were compared among groups. Results: Retinoschisis was found in 195 (43.5%) eyes, among which 170 (37.9%) had PVRS, 123 (27.5%) had PPRS, and 103 (23.0%) had MRS. MRS was found to be combined with PVRS in 96 of 103 (93.2%) eyes. MAM was one of the risk factors for RS (odds ratio [OR], 2.459; p = 0.005). Higher nasal PSH was the only risk factor for PVRS (OR, 9.103; p = 0.008 per 1‐mm increase). Elongation of axial length (AL) (OR, 1.891; p < 0.001 per 1‐mm increase), higher PSH in nasal (OR, 5.059; p = 0.009 per 1‐mm increase) and temporal (OR, 13.021; p = 0.012 per 1‐mm increase), epiretinal membrane (ERM; OR, 2.841; p = 0.008) and vitreomacular traction (VMT; OR, 7.335; p = 0.002) were risk factors for MRS. Conclusions: Paravascular retinoschisis is the most common type of RS in HM and MRS is mostly combined with PVRS. MAM is one of the risk factors for RS. In addition to longer AL and higher PSH, the presence of VMT and ERM also play an important role in the formation of MRS. [ABSTRACT FROM AUTHOR]

Published
2023
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164. Sympathetic Nervous System Activity is Associated with Choroidal Thickness and Axial Length in School-Aged Children: Longitudinal Evidence for Mechanism of Myopia

Author

Lin, Senlin, primary, Zhu, Bijun, additional, Wang, Ting, additional, Wang, Hong, additional, Xu, Xian, additional, Wang, Shanshan, additional, Yin, Yao, additional, Xiang, Zhaoyu, additional, Qian, Yu, additional, Zhang, Zhang, additional, Cui, Lipu, additional, Zou, Haidong, additional, He, Xiangui, additional, Zhu, Jianfeng, additional, and Ma, Yingyan, additional

Published
2022
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166. Prevalence of myopia and high myopia, and the association with education: Shanghai Child and Adolescent Large-scale Eye Study (SCALE): a cross-sectional study

Author

He, Xiangui, primary, Sankaridurg, Padmaja, additional, Xiong, Shuyu, additional, Li, Wayne, additional, Naduvilath, Thomas, additional, Lin, Senlin, additional, Weng, Rebecca, additional, Lv, Minzhi, additional, Ma, Yingyan, additional, Lu, Lina, additional, Wang, Jingjing, additional, Zhao, Rong, additional, Resnikoff, Serge, additional, Zhu, Jianfeng, additional, Zou, Haidong, additional, and Xu, Xun, additional

Published
2021
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169. Early Retinal Microvasculopathy in Prediabetic Patients and Correlated Factors.

Author

Xu, Yi, Zhu, Xiaofeng, Wang, Yongyi, Chu, Zhongdi, Wang, Ruikang K., Lu, Lina, and Zou, Haidong

Subjects
LDL cholesterol, OPTICAL coherence tomography, GLOMERULAR filtration rate, KIDNEY physiology, PREDIABETIC state
Abstract

Introduction: We aimed to detect early retinal microcirculation changes in prediabetic patients and investigate their correlation with clinical examinations. Methods: Forty-seven prediabetic individuals, 29 controls, and 81 type 2 diabetic mellitus (T2DM) patients were enrolled in this study. A review of clinical data and spectral-domain optical coherence tomography angiography (SD-OCTA) parameters of macular vessel diameter (VD), foveal avascular zone (FAZ), and macular vessel area density (VAD) was performed. Results: Levels of low-density lipoprotein cholesterol and triglycerides in prediabetes and T2DM groups were significantly higher than those in the control group. The urine microalbumin-to-creatinine ratio (ACR) was mildly and moderately increased in the prediabetes and T2DM groups, respectively. The estimated glomerular filtration rate of the three groups was within the normal range. SD-OCTA showed that VAD in the superficial macular area was decreased in the prediabetes group compared to the control group (p = 0.01). The FAZ size, particularly in the deep layer, was expanded in the prediabetes group. In the deep retinal layer of the macular area, VD and FAZ size in the prediabetes group were larger than those in the control group. In the prediabetes group, the axial length was significantly correlated with macular VD and FAZ size (p < 0.05), and ACR was correlated with FAZ size (p < 0.05). Age had a negative correlation with VAD (p < 0.01). ACR had a positive correlation with FAZ size (p < 0.05). Conclusions: Enlargement and irregularity of the FAZ area, deep capillary dilation, and a decrease in VAD occur in the retina of prediabetic patients with mild kidney function impairment. [ABSTRACT FROM AUTHOR]

Published
2023
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183. A Brief Metric Framework for Patient Adherence to Doctor’s Advice Based on Behavioral Economics

Author

Lin,Senlin, Ma,Yingyan, and Zou,Haidong

Subjects
Patient Preference and Adherence
Abstract

Senlin Lin, 1, 2,* Yingyan Ma, 1, 2,* Haidong Zou 1, 2 1Department of Eye Disease Prevention, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai 200010, People’s Republic of China; 2Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haidong ZouDepartment of Eye Disease Prevention, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kang Ding Road, Shanghai 200010, People’s Republic of ChinaTel +86 133 1198 6528Email zouhaidong@263.netPurpose: This study tried to establish a metric framework of patient adherence to doctor’s advice based on the expected utility and prospect theories, and it explained why the key to patient adherence to doctor’s advice is patients’ perceptions.Methods: Our framework is primarily based on two mature theories: expected utility theory and prospect theory. We started with a basic assumption: the doctor is rational and cares for patient’s health utility. We analyzed the expected utility of therapy with a definite diagnosis. Then, we considered the impacts of the accuracy of diagnostic techniques. After that, we explored the patient’s response to the doctors’ advices based on behavioral economics. In addition, we launched a discrete choice experiment to test our main point: perception is the key to patients’ adherence. A total of 200 undergraduate students participated in the discrete choice experiment.Results: Three main factors might impact a rational clinical decision: the therapeutic and side effects of the treatment, patient’s true disease risk, and diagnostic accuracy. However, another factor, patient’s individual percepion, was crucial for patient’s adherence since it may bias the patient’s estimations regarding the above three factors. As a result, doctors and patients would have a cognitive gap in the estimation of the disease and the treatment.Conclusion: The results indicate that without the necessary information, better clinical techniques may not help to improve patient adherence, which support our theoretical reasoning forcefully. Therefore, improving patient adherence should be more of a process of empathy and communication rather than a promotion of medical technology.Keywords: patient adherence, behavioral economics, discrete choice experiment

Published
2020

184. Eyes grow towards mild hyperopia rather than emmetropia in Chinese preschool children

Author

Ma, Yingyan, Lin, Senlin, Morgan, Ian, Rozema, Jos J, Iribarren, Rafael, Zhu, Jianfeng, Zhao, Rong, Zhang, Bo, Yin, Yao, Shao, Yueqin, He, Xiangui, Xu, Xun, Zou, Haidong, Ma, Yingyan, Lin, Senlin, Morgan, Ian, Rozema, Jos J, Iribarren, Rafael, Zhu, Jianfeng, Zhao, Rong, Zhang, Bo, Yin, Yao, Shao, Yueqin, He, Xiangui, Xu, Xun, and Zou, Haidong

Abstract

Purpose: To document one-year changes in refraction and refractive components in preschool children. Methods: Children, 3–5 years old, in the Jiading District, Shanghai, were followed for one year. At each visit, axial length (AL), refraction under cycloplegia (1% cyclopentolate), spherical dioptres (DS), cylinder dioptres (DC), spherical equivalent refraction (SER) and corneal curvature radius (CR) were measured. Results: The study included 458 right eyes of 458 children. The mean changes in DS, DC and SER were 0.02 ± 0.35 D, −0.02 ± 0.33 D and 0.01 ± 0.37 D, while the mean changes in AL, CR and lens power (LP) were 0.27 ± 0.10 mm, 0.00 ± 0.04 mm and − 0.93 ± 0.49 D. The change in the SER was linearly correlated with the baseline SER (coefficient = −0.147, p < 0.001). When the baseline SER was at 1.05 D (95% CI = 0.21 to 2.16), the change in SER was 0 D. The baseline SER was also linearly associated with the change in LP (coefficient = 0.104, p = 0.013), but not with the change in AL (p = 0.957) or with the change in CR (p = 0.263). Conclusion: In eyes with a baseline SER less than +1.00 D, LP loss was higher compared to axial elongation, leading to hyperopic shifts in refraction, whereas for those with baseline SER over this range, loss of LP compared to axial elongation was reduced, leading to myopic shifts. This model indicated the homeostasis of human refraction and explained how refractive development leads to a preferred state of mild hyperopia.

Published
2021

185. IMI Impact of Myopia

Author

Sankaridurg, Padmaja, primary, Tahhan, Nina, additional, Kandel, Himal, additional, Naduvilath, Thomas, additional, Zou, Haidong, additional, Frick, Kevin D., additional, Marmamula, Srinivas, additional, Friedman, David S., additional, Lamoureux, Ecosse, additional, Keeffe, Jill, additional, Walline, Jeffrey J., additional, Fricke, Timothy R., additional, Kovai, Vilas, additional, and Resnikoff, Serge, additional

Published
2021
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189. Prevalence of fundus tessellation and its associated factors in Chinese children and adolescents with high myopia

Author

Cheng, Tianyu, primary, Deng, Junjie, additional, Xu, Xian, additional, Zhang, Bo, additional, Wang, Jingjing, additional, Xiong, Shuyu, additional, Du, Yuchen, additional, Yu, Suqin, additional, Gong, Wei, additional, Zhao, Huijuan, additional, Luan, Mengli, additional, Fan, Ying, additional, Zhu, Jianfeng, additional, Zou, Haidong, additional, Xu, Xun, additional, and He, Xiangui, additional

Published
2021
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192. Higher-order aberrations and their association with axial elongation in highly myopic children and adolescents

Author

Xu, Yupeng, Deng, Junjie, Zhang, Bo, Xu, Xian, Cheng, Tianyu, Wang, Jingjing, Xiong, Shuyu, Luan, Mengli, Zou, Haidong, He, Xiangui, Tang, Chun, and Xu, Xun

Abstract

BackgroundVision-dependent mechanisms play a role in myopia progression in childhood. Thus, we investigated the distribution of ocular and corneal higher-order aberrations (HOAs) in highly myopic Chinese children and adolescents and the relationship between HOA components and 1-year axial eye growth.MethodsBaseline cycloplegic ocular and corneal HOAs, axial length (AL), spherical equivalent (SE), astigmatism and interpupillary distance (IPD) were determined for the right eyes of 458 highly myopic (SE ≤−5.0D) subjects. HOAs were compared among baseline age groups (≤12 years, 13–15 years and 16–18 years). Ninety-nine subjects completed the 1-year follow-up. Linear mixed model analyses were applied to determine the association between HOA components, other known confounding variables (age, gender, SE, astigmatism and IPD) and axial growth. A comparison with data from an early study of moderate myopia were conducted.ResultsAlmost all ocular HOAs and few corneal HOAs exhibited significant differences between different age groups (all p<0.05). After 1 year, only ocular HOA components was significantly negative associated with a longer AL, including secondary horizontal comatic aberration (p=0.019), primary spherical aberration (p<0.001) and spherical HOA (p=0.026). Comparing with the moderate myopia data, the association of comatic aberration with AL growth was only found in high myopia.ConclusionIn highly myopic children and adolescents, lower levels of annual ocular secondary horizontal comatic aberration changes, besides spherical aberrations, were associated with axial elongation. This suggests that ocular HOA plays a potential role in refractive development in high myopia.

Published
2023
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193. Role of corneal radius of curvature in early identification of fundus tessellation in children with low myopia

Author

Gong, Wei, Cheng, Tianyu, Wang, Jingjing, Zhang, Bo, Chen, Jun, Zhu, Jianfeng, Zou, Haidong, Liu, Kun, He, Xiangui, and Xu, Xun

Abstract

AimTo assess the role of the corneal radius of curvature (CR) in the identification of fundus tessellation in children with low myopia.MethodsIn the cross-sectional study, students aged 9–12 years from 24 primary schools in Shanghai were enrolled by cluster sampling. Participants underwent measurements including cycloplegic refraction and axial length. Fundus images and choroidal thickness were obtained by swept-source optical coherence tomography. Fundus tessellation was classified into four grades according to fundus photographs.ResultsA total of 1127 children with low myopia (spherical equivalence (SE) >−3.00 dioptre (D) but ≤−0.50 D) were included, with a mean age of 10.29±0.60 years and a mean SE of −1.44±0.69 D. Fundus tessellation was found in 591 (52.4%) cases (grade 1: 428, 38.0%; grade 2: 128, 11.4%; grade 3: 35, 3.1%). Choroidal thickness decreased as fundus tessellation grade increased (p trend <0.001). According to regression analysis, higher fundus tessellation grade was independently associated with larger CR (OR, 7.499; 95% CI 2.279 to 24.675, p=0.001). For those with CR >7.9 mm, along with CR, degree and proportion of fundus tessellation increased sharply.ConclusionFundus tessellation existed in more than half of children with low myopia. Preliminary fundus photography conducted in children with low myopia with large CR would be necessary and beneficial to the early management of myopic fundus changes.Trial registration numberNCT02980445.

Published
2023
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194. Normative data and percentile curves for axial length and axial length/corneal curvature in Chinese children and adolescents aged 4–18 years

Author

He, Xiangui, Sankaridurg, Padmaja, Naduvilath, Thomas, Wang, Jingjing, Xiong, Shuyu, Weng, Rebecca, Du, Linlin, Chen, Jun, Zou, Haidong, and Xu, Xun

Abstract

PurposeTo develop age-specific and gender-specific reference percentile charts for axial length (AL) and AL/corneal radius of curvature (AL/CR) and, to use percentiles to determine probability of myopia and estimate refractive error (RE).MethodsAnalysis of AL, cycloplegic RE and CR of 14 127 Chinese participants aged 4–18 years from 3 studies. AL and AL/CR percentiles estimated using Lambda-Mu-Sigma method and compared for agreement using intraclass correlation (ICC). Logistic regression was used to model risk of myopia based on age, gender, AL and AL/CR percentiles. Accuracy of AL progression and RE estimated using percentiles was validated using an independent sample of 5742 eyes of children aged 7–10 years.ResultsAge-specific and gender-specific AL and AL/CR (3rd, 5th, 10th, 25th, 50th, 75th, 90th and 95th) percentiles are presented. Concordance between AL and AL/CR percentiles improved with age (0.13 at 4 years to >0.75 from 13 years) and a year-to-year change was observed for all except <10th percentile from 15 years. Increasing age, AL and AL/CR was associated with a more myopic RE (r2=0.45,0.70 and 0.83, respectively). The sensitivity and specificity of the model to estimate probability of myopia was 86.0% and 84.5%, respectively. Estimation of 1-year change in AL using percentiles correlated highly with actual AL (ICC=0.98). Concordance of estimated to actual RE was high (ICC=0.80) and within ±0.50D and ±1.0D of actual RE for 47.4% and 78.9% of eyes, respectively.ConclusionAge-specific and gender-specific AL and AL/CR percentiles provide reference data, aid in identifying and monitoring individuals at risk of myopia and have utility in screening for myopia. AL/CR percentiles were more accurate in estimating probability of myopia in younger children.

Published
2023
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196. Accelerated loss of crystalline lens power initiating from emmetropia among young school children: a 2‐year longitudinal study.

Author

Xiong, Shuyu, He, Xiangui, Sankaridurg, Padmaja, Zhu, Jianfeng, Wang, Jingjing, Zhang, Bo, Zou, Haidong, and Xu, Xun

Subjects
CRYSTALLINE lens, VISUAL accommodation, SCHOOL children, REFRACTIVE errors, LONGITUDINAL method, CHILDREN with intellectual disabilities
Abstract

Purpose: To determine the characteristics of crystalline lens with varying refractive errors and relationship with axial elongation in young school children. Methods: A total of 1465 children aged 6–8 years were examined annually for 2 years. Each participant underwent a series of ophthalmic examinations, including cycloplegic autorefraction, crystalline lens and axial length measurement. Crystalline lens power was determined, and factors associated with different refractive statuses were investigated. Results: Crystalline lens power decreased with time; reduction in lens power in Year 1 was greater in children with emmetropia (−0.69 ± 0.59 dioptre [D]) than in those with hyperopia (−0.49 ± 0.56 D) or myopia (−0.45 ± 0.55 D) (p < 0.001). Among the emmetropes, there were no differences in loss of crystalline lens power between those who remained emmetropic (−0.63 ± 0.59 D) and those who became myopic at Year 1 (−0.74 ± 0.61 D) and Year 2 (−0.77 ± 0.57 D, p > 0.05) visits. Among myopes at Year 1 visit, there was a greater reduction at Year 2 in those who had baseline emmetropia (−0.61 ± 0.51 D) than those who had baseline myopia (−0.26 ± 0.49 D, p < 0.001). The trend was similar among children of the same age. There was a significant correlation between changes in lens power and axial elongation in non‐myopia (β = −0.954, p < 0.001) and new myopia (β = −1.178, p < 0.001), but not in established myopia (β = −0.001, p = 0.539). Conclusions: There is accelerated loss of lens power in emmetropia and early stage of myopia. However, this loss is retarded when myopia persists and is accompanied by disappearance of the compensatory effect of lens power against axial elongation. These findings provide new insights into human refractive development. [ABSTRACT FROM AUTHOR]

Published
2022
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200. Design and Pilot data of the high myopia registration study: Shanghai Child and Adolescent Large‐scale Eye Study (SCALE‐HM)

Author

He, Xiangui, primary, Deng, Junjie, additional, Xu, Xian, additional, Wang, Jingjing, additional, Cheng, Tianyu, additional, Zhang, Bo, additional, Zhao, Huijuan, additional, Luan, Mengli, additional, Fan, Ying, additional, Xiong, Shuyu, additional, Zhu, Jianfeng, additional, Zou, Haidong, additional, and Xu, Xun, additional

Published
2020
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