34,349 results on '"Zink, A"'
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152. The 68th annual conference on magnetism and magnetic materials
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Barry L. Zink
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Physics ,QC1-999 - Abstract
The 2023 Conference on Magnetism and Magnetic Materials (MMM) was held from October 30–November 3 at the Dallas Hyatt Regency, at the base of the iconic Reunion Tower. There, 703 on-site attendees from 37 different countries discussed cutting-edge research in fundamental and applied magnetism, made new connections, and met old friends and colleagues at one of the first primarily in-person conferences in our field since the major disruptions of the pandemic era. The format of the conference was primarily in-person, with supporting online content that included recordings of the most popular programs and presentations, made available after the conference (including all symposia, the tutorial, and selected other special content). All presenters had the option to contribute online content, as did 96 participants who did not travel to the venue and elected to present virtual posters. Attendees enjoyed a vibrant celebration of the magnetism research community that included a Texas-sized welcome reception, tutorials on machine learning in magnetism, seven symposia, a lively exhibit hall that hosted poster sessions and bierstuben, a full roster of special events, coffee breaks to facilitate active scientific discussions, and of course, excellent technical presentations. These technical presentations, organized into 45 oral sessions, 23 in-person poster sessions, and 17 virtual poster sessions, were selected by a Program Committee of 57 members, capably coordinated by three Program Chairs: Hendrik Ohldag (ALS-LBNL), Karin Leistner (TU Chemnitz), and Takahiro Moriyama (Nagoya University). These three Program Chairs worked seamlessly and tirelessly over many months to make the central mission of MMM a huge success. The Program Committee selected seven symposia from nominations provided by the magnetism community: “Frontier Topics in Antiferromagnetism: Altermagnetism and Topology,” “Rare Earth Spintronics,” “Recent Advances in Cavity Magnonics,” “Emerging Topics in Magnetic Tunnel Junctions: Altermagnetism, Probabilistic Computing and Energy Efficient Switching,” “Orbitronics: From Orbital Currents Created by Charge Currents to Creation by Light or RF Excitation,” “Imaging Magnetic Textures at the Nanoscale,” and finally “Magnetization Dynamics in Two-Dimensional van der Waals Magnets.” These symposia highlighted a wide range of exciting new areas for magnetism, and were part of a total of 101 invited talks, 28% of which were presented by women. The contributed program was selected by the Program Committee from more than 900 submitted abstracts.
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- 2024
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153. A Multiport Coaxial Interconnection for MTCA.4 Based High-Frequency Instrumentation Applications.
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Johannes Zink 0002, Frank Ludwig, Szymon Jablonski, Uros Mavric, Michael Fenner, Stanislav Chystiakov, Holger Schlarb, and Friedel Gerfers
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- 2024
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154. Unmet Needs in Darier’s Disease from a Patient’s Perspective: Lessons Learnt from the German Registry
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Danielle Rogner, Laura Heimerl, Tilo Biedermann, Elke Sattler, and Alexander Zink
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Darier’s disease ,genodermatosis ,orphan disease ,disease burden ,registry ,Dermatology ,RL1-803 - Abstract
The MDHHgermany registry was initiated to characterize the “real-life” situation of affected individuals with Darier’s disease (DD; Morbus Darier, MD) and Hailey-Hailey disease (HH), including their treatment and healthcare. To gain deeper insights into medical care of patients with DD, various aspects such as demographics, subjective symptoms, patient satisfaction with medical care, past and current therapies were explored. Patients with diagnosed DD were included. Subjective symptoms such as itch, pain and burning sensation were assessed. Individual therapy goals were recorded and patients assessed previous/current therapies along with satisfaction of medical care and treatment. A total of 55 patients were recruited; 47 patients were eligible for the analysis. Pruritus was rated the most bothersome symptom. Some 42.6% had not received systemic treatment so far or systemic therapies were rated ineffective (32.6%). Most commonly oral retinoids were prescribed, followed by corticosteroids. Patient satisfaction with medical care and treatment proved to be mediocre. This “real-life” data show an alarming unmet need regarding patients’ satisfaction with medical care and treatment, evidenced by the reported lack of disease control. Further studies and interventions are needed to improve the spectrum of available therapies. MDHHgermany provides a foundational platform for future clinical trials, epidemiological studies, and pathophysiological analyses.
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- 2024
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155. 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
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Marian Brenner, Christoph Zink, Linda Witzinger, Angelika Keller, Kerstin Hadamek, Sebastian Bothe, Martin Neuenschwander, Carmen Villmann, Jens Peter von Kries, Hermann Schindelin, Elisabeth Jeanclos, and Antje Gohla
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vitamin B6 ,cognition ,pyridoxal phosphatase ,pyridoxal phosphatase inhibitor ,7,8-dihydroxyflavone ,X-ray crystal structure ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation improves cognition is unclear as well. Pyridoxal 5’-phosphate phosphatase (PDXP), an enzyme that controls levels of pyridoxal 5’-phosphate (PLP), the co-enzymatically active form of vitamin B6, may represent an alternative therapeutic entry point into vitamin B6-associated pathologies. However, pharmacological PDXP inhibitors to test this concept are lacking. We now identify a PDXP and age-dependent decline of PLP levels in the murine hippocampus that provides a rationale for the development of PDXP inhibitors. Using a combination of small-molecule screening, protein crystallography, and biolayer interferometry, we discover, visualize, and analyze 7,8-dihydroxyflavone (7,8-DHF) as a direct and potent PDXP inhibitor. 7,8-DHF binds and reversibly inhibits PDXP with low micromolar affinity and sub-micromolar potency. In mouse hippocampal neurons, 7,8-DHF increases PLP in a PDXP-dependent manner. These findings validate PDXP as a druggable target. Of note, 7,8-DHF is a well-studied molecule in brain disorder models, although its mechanism of action is actively debated. Our discovery of 7,8-DHF as a PDXP inhibitor offers novel mechanistic insights into the controversy surrounding 7,8-DHF-mediated effects in the brain.
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- 2024
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156. Population-specific thermal responses contribute to regional variability in arbovirus transmission with changing climates
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Rachel L. Fay, Mauricio Cruz-Loya, Alexander C. Keyel, Dana C. Price, Steve D. Zink, Erin A. Mordecai, and Alexander T. Ciota
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Virology ,Entomology ,Global change ,Microbiology ,Science - Abstract
Summary: Temperature is increasing globally, and vector-borne diseases are particularly responsive to such increases. While it is known that temperature influences mosquito life history traits, transmission models have not historically considered population-specific effects of temperature. We assessed the interaction between Culex pipiens population and temperature in New York State (NYS) and utilized novel empirical data to inform predictive models of West Nile virus (WNV) transmission. Genetically and regionally distinct populations from NYS were reared at various temperatures, and life history traits were monitored and used to inform trait-based models. Variation in Cx. pipiens life history traits and population-dependent thermal responses account for a predicted 2.9°C difference in peak transmission that is reflected in regional differences in WNV prevalence. We additionally identified genetic signatures that may contribute to distinct thermal responses. Together, these data demonstrate how population variation contributes to significant geographic variability in arbovirus transmission with changing climates.
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- 2024
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157. Leveraging web search data in Germany to identify unmet needs of contraceptives on a population-based level: A longitudinal retrospective study
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Charlotte Steiner, Hannah Wecker, Linda Tizek, Stefanie Ziehfreund, Sarah Preis, Kerstin Pfister, Viktoria Oberländer, Tilo Biedermann, and Alexander Zink
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Medicine - Abstract
Background: There are a variety of possible contraceptives available. While medical advice is an important resource for selecting the individual contraceptive, previous research has shown that the Internet has become an increasingly important source of health care information. Objectives: This study aims to identify key trends in contraception-related web searches in Germany and thus allows conclusions about preferences and unmet needs with regard to pregnancy prevention. Design: Longitudinal retrospective study. Methods: Google Ads Keyword Planner was used to identify contraception-related keywords and their search volume in Germany and all federal states between 2018 and 2021. The keywords were categorized based on gender, hormonal/non-hormonal, and different contraceptive methods. Search volume and categories were analyzed for temporal trends, regional differences, and underlying socioeconomic variables. Results: The 1481 contraception-related keywords corresponded to 15,081,760 searches. In total, a 56% increase in searches/100,000 inhabitants was observed. Highest mean search volume was observed in categories “woman,” “woman/non-hormonal” and “woman/non-hormonal/barrier,” respectively, and in the federal state Hamburg, while the lowest was seen in North Rhine-Westphalia. Conclusion: The increase in search volume reflects a high interest in contraception, particularly in non-hormonal female methods. This stands in contrast to the limited number of effective non-hormonal contraceptives available and points to an unmet need. In addition, the low search volume for male contraceptives demonstrates gender-specific responsibilities regarding family planning in German society.
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- 2024
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158. Impact of DMARD treatment and systemic inflammation on all-cause mortality in patients with rheumatoid arthritis and interstitial lung disease: a cohort study from the German RABBIT register
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Angela Zink, Hanns-Martin Lorenz, Anja Strangfeld, Andreas Krause, Yvette Meissner, Tatjana Rudi, Vera Zietemann, Christian Kneitz, and Martin Schaefer
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Medicine - Abstract
Objectives To investigate the impact of disease activity and treatment with disease-modifying antirheumatic drugs (DMARDs) on all-cause mortality in patients with rheumatoid arthritis and prevalent interstitial lung disease (RA-ILD).Methods Patients with RA-ILD were selected from the biologics register Rheumatoid Arthritis: Observation of Biologic Therapy (RABBIT). Using time-varying Cox regression, the association between clinical measures and mortality was investigated. The impact of DMARDs was analysed by (1) Cox regression considering cumulative exposure (ie, treatment months divided by total months) and (2) time-varying Cox regression as main approach (treatment exposures at monthly level).Results Out of 15 566 participants, 381 were identified as RA-ILD cases with 1258 person-years of observation and 2.6 years median length of follow-up. Ninety-seven patients (25.5%) died and 34 (35.1%) of these were not receiving DMARD therapy at the time of death. Higher inflammatory biomarkers but not swollen and tender joint count were significantly associated with mortality. Compared with tumour necrosis factor inhibitors (TNFi), non-TNFi biologic DMARDs (bDMARDs) exhibited adjusted HRs (aHRs) for mortality below 1, lacking statistical significance. This finding was stable in various sensitivity analyses. Joint aHR for non-TNFi biologics and JAKi versus TNFi was 0.56 (95% CI 0.33 to 0.97). Receiving no DMARD treatment was associated with a twofold higher mortality risk compared with receiving any DMARD treatment, aHR 2.03 (95% CI 1.23 to 3.35).Conclusions Inflammatory biomarkers and absence of DMARD treatment were associated with increased risk of mortality in patients with RA-ILD. Non-TNFi bDMARDs may confer enhanced therapeutic benefits in patients with RA-ILD.
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- 2024
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159. $^{57}$Zn $\beta$-delayed proton emission establishes the $^{56}$Ni $rp$-process waiting point bypass
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Saxena, M., Ong, W. -J, Meisel, Z., Hoff, D. E. M., Smirnova, N., Bender, P. C., Burcher, S. P., Carpenter, M. P., Carroll, J. J., Chester, A., Chiara, C. J., Conaway, R., Copp, P. A., Crider, B. P., Derkin, J., Estrade, A., Hamad, G., Harke, J. T., Jain, R., Jayatissa, H., Liddick, S. N., Longfellow, B., Mogannam, M., Montes, F., Nepal, N., Ogunbeku, T. H., Richard, A. L., Schatz, H., Soltesz, D., Subedi, S. K., Sultana, I., Tamashiro, A. S., Tripathi, V., Xiaog, Y., and Zink, R.
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Nuclear Experiment ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We measured the $^{57}$Zn $\beta$-delayed proton ($\beta$p) and $\gamma$ emission at the National Superconducting Cyclotron Laboratory. We find a $^{57}$Zn half-life of 43.6 $\pm$ 0.2 ms, $\beta$p branching ratio of (84.7 $\pm$ 1.4)%, and identify four transitions corresponding to the exotic $\beta$-$\gamma$-$p$ decay mode, the second such identification in the $f p$-shell. The $p/\gamma$ ratio was used to correct for isospin mixing while determining the $^{57}$Zn mass via the isobaric multiplet mass equation. Previously, it was uncertain as to whether the rp-process flow could bypass the textbook waiting point $^{56}$Ni for astrophysical conditions relevant to Type-I X-ray bursts. Our results definitively establish the existence of the $^{56}$Ni bypass, with 14-17% of the $rp$-process flow taking this route.
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- 2022
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160. An Information Centric Framework for Weather Sensing Data
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Thompson, Robert, Lyons, Eric, Dasgupta, Ishita, Mastorakis, Spyridon, Zink, Michael, and Shannigrahi, Susmit
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Computer Science - Networking and Internet Architecture - Abstract
Weather sensing and forecasting has become increasingly accurate in the last decade thanks to high-resolution radars, efficient computational algorithms, and high-performance computing facilities. Through a distributed and federated network of radars, scientists can make high-resolution observations of the weather conditions on a scale that benefits public safety, commerce, transportation, and other fields. While weather radars are critical infrastructure, they are often located in remote areas with poor network connectivity. Data retrieved from these radars are often delayed or lost, or even lack proper synchronization, resulting in sub-optimal weather prediction. This work applies Named Data Networking (NDN) to a federation of weather sensing radars for efficient content addressing and retrieval. We identify weather data based on a hierarchical naming scheme that allows us to explicitly access desired files. We demonstrate that compared to the window-based mechanism in TCP/IP, an NDN based mechanism improves data quality, reduces uncertainty, and enhances weather prediction. Our evaluation demonstrates that this naming scheme enables effective data retrieval, while compared to the window-based mechanism in TCP/IP, an NDN based mechanism improves data quality, reduces uncertainty, and enhances weather prediction., Comment: This paper has been accepted for publication by a workshop held in conjunction with the IEEE International Conference on Communications (ICC) 2022
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- 2022
161. Design and Performance of the Prototype Schwarzschild-Couder Telescope Camera
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Adams, Colin B., Ambrosi, Giovanni, Ambrosio, Michelangelo, Aramo, Carla, Arlen, Timothy, Benbow, Wystan, Bertucci, Bruna, Bissaldi, Elisabetta, Biteau, Jonathan, Bitossi, Massimiliano, Boiano, Alfonso, Bonavolontà, Carmela, Bose, Richard, Bouvier, Aurelien, Buscemi, Mario, Brill, Aryeh, Brown, Anthony M., Buckley, James H., Canestrari, Rodolfo, Capasso, Massimo, Caprai, Mirco, Coppi, Paolo, Covault, Corbin E., Depaoli, Davide, Di Venere, Leonardo, Errando, Manel, Fegan, Stephen, Feng, Qi, Fiandrini, Emanuele, Furniss, Amy, Garczarczyk, Markus, Gent, Alasdair, Giglietto, Nicola, Giordano, Francesco, Giro, Enrico, Halliday, Robert, Hervet, Olivier, Hughes, Gareth, Incardona, Simone, Humensky, Thomas B., Ionica, Maria, Jin, Weidong, Johnson, Caitlin A., Kieda, David, Krennrich, Frank, Kuznetsov, Andrey, Lapington, Jon, Licciulli, Francesco, Loporchio, Serena, Marsella, Giovanni, Masone, Vincenzo, Meagher, Kevin, Meures, Thomas, Mode, Brent A. W., Mognet, Samuel A. I., Mukherjee, Reshmi, Okumura, Akira, Pantaleo, Francesca R., Paoletti, Riccardo, Di Pierro, Federico, Ribeiro, Deivid, Riitano, Luca, Roache, Emmet, Ross, Duncan, Rousselle, Julien, Rugliancich, Andrea, Santander, Marcos, Schneider, Michael, Schoorlemmer, Harm, Shang, Ruo-Yu, Stevenson, Brandon, Stiaccini, Leonardo, Tajima, Hiroyasu, Taylor, Leslie P., Thornhill, Julian, Tosti, Luca, Tripodo, Giovanni, Vagelli, Valerio, Valentino, Massimo, Vandenbroucke, Justin, Vassiliev, Vladimir V., Wakely, Scott P., Watson, Jason J., White, Richard, Wilcox, Patrick, Williams, David A., Wood, Matthew, Yu, Peter, and Zink, Adrian
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The prototype Schwarzschild-Couder Telescope (pSCT) is a candidate for a medium-sized telescope in the Cherenkov Telescope Array. The pSCT is based on a novel dual mirror optics design which reduces the plate scale and allows for the use of silicon photomultipliers as photodetectors. The prototype pSCT camera currently has only the central sector instrumented with 25 camera modules (1600 pixels), providing a 2.68$^{\circ}$ field of view (FoV). The camera electronics are based on custom TARGET (TeV array readout with GSa/s sampling and event trigger) application specific integrated circuits. Field programmable gate arrays sample incoming signals at a gigasample per second. A single backplane provides camera-wide triggers. An upgrade of the pSCT camera is in progress, which will fully populate the focal plane. This will increase the number of pixels to 11,328, the number of backplanes to 9, and the FoV to 8.04$^{\circ}$. Here we give a detailed description of the pSCT camera, including the basic concept, mechanical design, detectors, electronics, current status and first light.
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- 2022
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162. White Paper on Light Sterile Neutrino Searches and Related Phenomenology
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Acero, M. A., Argüelles, C. A., Hostert, M., Kalra, D., Karagiorgi, G., Kelly, K. J., Littlejohn, B., Machado, P., Pettus, W., Toups, M., Ross-Lonergan, M., Sousa, A., Surukuchi, P. T., Wong, Y. Y. Y., Abdallah, W., Abdullahi, A. M., Akutsu, R., Alvarez-Ruso, L., Alves, D. S. M., Aurisano, A., Balantekin, A. B., Berryman, J. M., Bertólez-Martínez, T., Brunner, J., Blennow, M., Bolognesi, S., Borusinski, M., Cianci, D., Collin, G., Conrad, J. M., Crow, B., Denton, P. B., Duvall, M., Fernández-Martinez, E., Fong, C. S., Foppiani, N., Forero, D. V., Friend, M., García-Soto, A., Giganti, C., Giunti, C., Gandhi, R., Ghosh, M., Hardin, J., Heeger, K. M., Ishitsuka, M., Izmaylov, A., Jones, B. J. P., Jordan, J. R., Kamp, N. W., Katori, T., Kim, S. B., Koerner, L. W., Lamoureux, M., Lasserre, T., Leach, K. G., Learned, J., Li, Y. F., Link, J. M., Louis, W. C., Mahn, K., Meyers, P. D., Maricic, J., Marko, D., Maruyama, T., Mertens, S., Minakata, H., Mocioiu, I., Mooney, M., Moulai, M. H., Nunokawa, H., Ochoa-Ricoux, J. P., Oh, Y. M., Ohlsson, T., Päs, H., Pershey, D., Robertson, R. G. H., Rosauro-Alcaraz, S., Rott, C., Roy, S., Salvado, J., Scott, M., Seo, S. H., Shaevitz, M. H., Smiley, M., Spitz, J., Stachurska, J., Thakore, T., Ternes, C. A., Thompson, A., Tseng, S., Vogelaar, B., Weiss, T., Wendell, R. A., Wright, T., Xin, Z., Yang, B. S., Yoo, J., Zennamo, J., Zettlemoyer, J., Zornoza, J. D., Ahmad, S., Basto-Gonzalez, V. S., Bowden, N. S., Cañas, B. C., Caratelli, D., Chang, C. V., Chen, C., Classen, T., Convery, M., Davies, G. S., Dennis, S. R., Djurcic, Z., Dorrill, R., Du, Y., Evans, J. J., Fahrendholz, U., Formaggio, J. A., Foust, B. T., Gatti, H. Frandini, Garcia-Gamez, D., Gariazzo, S., Gehrlein, J., Grant, C., Gomes, R. A., Hansell, A. B., Halzen, F., Ho, S., Zink, J. Hoefken, Jones, R. S., Kunkle, P., Li, J. -Y., Li, S. C., Luo, X., Malyshkin, Yu., Massaro, D., Mastbaum, A., Mohanta, R., Mumm, H. P., Nebot-Guinot, M., Neilson, R., Ni, K., Nieves, J., Gann, G. D. Orebi, Pandey, V., Pascoli, S., Qian, X., Rajaoalisoa, M., Roca, C., Roskovec, B., Saul-Sala, E., Saldaña, L., Scholberg, K., Shakya, B., Slocum, P. L., Snider, E. L., Steiger, H. Th. J., Steklain, A. F., Stock, M. R., Sutanto, F., Takhistov, V., Tsai, Y. -D., Tsai, Y. -T., Venegas-Vargas, D., Wallbank, M., Wang, E., Weatherly, P., Westerdale, S., Worcester, E., Wu, W., Yang, G., and Zamorano, B.
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High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
This white paper provides a comprehensive review of our present understanding of experimental neutrino anomalies that remain unresolved, charting the progress achieved over the last decade at the experimental and phenomenological level, and sets the stage for future programmatic prospects in addressing those anomalies. It is purposed to serve as a guiding and motivational "encyclopedic" reference, with emphasis on needs and options for future exploration that may lead to the ultimate resolution of the anomalies. We see the main experimental, analysis, and theory-driven thrusts that will be essential to achieving this goal being: 1) Cover all anomaly sectors -- given the unresolved nature of all four canonical anomalies, it is imperative to support all pillars of a diverse experimental portfolio, source, reactor, decay-at-rest, decay-in-flight, and other methods/sources, to provide complementary probes of and increased precision for new physics explanations; 2) Pursue diverse signatures -- it is imperative that experiments make design and analysis choices that maximize sensitivity to as broad an array of these potential new physics signatures as possible; 3) Deepen theoretical engagement -- priority in the theory community should be placed on development of standard and beyond standard models relevant to all four short-baseline anomalies and the development of tools for efficient tests of these models with existing and future experimental datasets; 4) Openly share data -- Fluid communication between the experimental and theory communities will be required, which implies that both experimental data releases and theoretical calculations should be publicly available; and 5) Apply robust analysis techniques -- Appropriate statistical treatment is crucial to assess the compatibility of data sets within the context of any given model., Comment: Contribution to Snowmass 2021 by the NF02 Topical Group (Understanding Experimental Neutrino Anomalies). Submitted to J. Phys. G as a Major Report
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- 2022
163. Boosting Mask R-CNN Performance for Long, Thin Forensic Traces with Pre-Segmentation and IoU Region Merging
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Zink, Moritz, Schiele, Martin, Fan, Pengcheng, and Gasterstädt, Stephan
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Robotics - Abstract
Mask R-CNN has recently achieved great success in the field of instance segmentation. However, weaknesses of the algorithm have been repeatedly pointed out as well, especially in the segmentation of long, sparse objects whose orientation is not exclusively horizontal or vertical. We present here an approach that significantly improves the performance of the algorithm by first pre-segmenting the images with a PSPNet algorithm. To further improve its prediction, we have developed our own cost functions and heuristics in the form of training strategies, which can prevent so-called (early) overfitting and achieve a more targeted convergence. Furthermore, due to the high variance of the images, especially for PSPNet, we aimed to develop strategies for a high robustness and generalization, which are also presented here., Comment: 9 Pages, 19 Figures
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- 2022
164. Scaling K2. V. Statistical Validation of 60 New Exoplanets From K2 Campaigns 2-18
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Christiansen, Jessie L., Bhure, Sakhee, Zink, Jon K., Hardegree-Ullman, Kevin K., Adkins, Britt Duffy, Hedges, Christina, Morton, Timothy D., Bieryla, Allyson, Ciardi, David R., Cochran, William D., Dressing, Courtney D., Everett, Mark E., Isaacson, Howard, Livingston, John H., Ziegler, Carl, Berlind, Perry, Calkins, Michael L., Esquerdo, Gilbert A., Latham, David W., Endl, Michael, MacQueen, Phillip J., Fulton, Benjamin J., Hirsch, Lea A., Howard, Andrew W., Weiss, Lauren M., Allen, Bridgette E., Berberyann, Arthur, Ciardi, Krys N., Dunlavy, Ava, Glassford, Sofia H., Dai, Fei, Hirano, Teruyuki, Tamura, Motohide, Beichman, Charles, Gonzales, Erica J., Schlieder, Joshua E., Barclay, Thomas, Crossfield, Ian J. M., Gilbert, Emily A., Matthews, Elisabeth C., Giacalone, Steven, and Petigura, Erik A.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The NASA K2 mission, salvaged from the hardware failures of the Kepler telescope, has continued Kepler's planet-hunting success. It has revealed nearly 500 transiting planets around the ecliptic plane, many of which are the subject of further study, and over 1000 additional candidates. Here we present the results of an ongoing project to follow-up and statistically validate new K2 planets, in particular to identify promising new targets for further characterization. By analyzing the reconnaissance spectra, high-resolution imaging, centroid variations, and statistical likelihood of the signals of 91 candidates, we validate 60 new planets in 46 systems. These include: a number of planets amenable to transmission spectroscopy (K2-384 f, K2-387 b, K2-390 b, K2-403 b, and K2-398 c), emission spectroscopy (K2-371 b, K2-370 b, and K2-399 b), and both (K2-405 b and K2-406 b); several systems with planets in or close to mean motion resonances (K2-381, K2-398) including a compact, TRAPPIST-1-like system of five small planets orbiting a mid-M dwarf (K2-384); an ultra-short period sub-Saturn in the hot Saturn desert (K2-399 b); and a super-Earth orbiting a moderately bright (V=11.93), metal-poor ([Fe/H]=-0.579+/-0.080) host star (K2-408 b). In total we validate planets around 4 F stars, 26 G stars, 13 K stars, and 3 M dwarfs. In addition, we provide a list of 37 vetted planet candidates that should be prioritized for future follow-up observation in order to be confirmed or validated., Comment: 50 pages, 14 figures, 7 tables, accepted in AJ; replaced to fix error in planet name (thanks Travis!) and error in figure label
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- 2022
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165. The Segment Number: Algorithms and Universal Lower Bounds for Some Classes of Planar Graphs
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Goeßmann, Ina, Klawitter, Jonathan, Klemz, Boris, Klesen, Felix, Kobourov, Stephen, Kryven, Myroslav, Wolff, Alexander, and Zink, Johannes
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Computer Science - Computational Geometry - Abstract
The segment number of a planar graph $G$ is the smallest number of line segments needed for a planar straight-line drawing of $G$. Dujmovi\'c, Eppstein, Suderman, and Wood [CGTA'07] introduced this measure for the visual complexity of graphs. There are optimal algorithms for trees and worst-case optimal algorithms for outerplanar graphs, 2-trees, and planar 3-trees. It is known that every cubic triconnected planar $n$-vertex graph (except $K_4$) has segment number $n/2+3$, which is the only known universal lower bound for a meaningful class of planar graphs. We show that every triconnected planar 4-regular graph can be drawn using at most $n+3$ segments. This bound is tight up to an additive constant, improves a previous upper bound of $7n/4+2$ implied by a more general result of Dujmovi\'c et al., and supplements the result for cubic graphs. We also give a simple optimal algorithm for cactus graphs, generalizing the above-mentioned result for trees. We prove the first linear universal lower bounds for outerpaths, maximal outerplanar graphs, 2-trees, and planar 3-trees. This shows that the existing algorithms for these graph classes are constant-factor approximations. For maximal outerpaths, our bound is best possible and can be generalized to circular arcs., Comment: Appears in the Proceedings of the 48th International Workshop on Graph-Theoretic Concepts in Computer Science (WG2022)
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- 2022
166. Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations
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Eldjarn, Grimur Hjorleifsson, Ferkingstad, Egil, Lund, Sigrun H., Helgason, Hannes, Magnusson, Olafur Th., Gunnarsdottir, Kristbjorg, Olafsdottir, Thorunn A., Halldorsson, Bjarni V., Olason, Pall I., Zink, Florian, Gudjonsson, Sigurjon A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Gisli H., Magnusson, Magnus K., Saevarsdottir, Saedis, Eiriksdottir, Thjodbjorg, Masson, Gisli, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorleifsson, Gudmar, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2024
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167. Frühe Hypertonie erhöht späteres kardiovaskuläres Risiko
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Zink, Nicola
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- 2024
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168. Betrunken ohne Alkoholaufnahme: An das Eigenbrauer-Syndrom denken!
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Zink, Nicola
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- 2024
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169. Diese Personengruppen sollten gegen RSV geimpft werden
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Zink, Nicola
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- 2024
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170. Oberflächliche Thrombose behandeln?
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Zink, Nicola
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- 2024
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171. Ständig Harnwegsinfekte: Was hätten Sie getan?
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Zink, Nicola
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- 2024
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172. Möglichst guter Impfschutz bei Immunsupprimierten besonders wichtig
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Zink, Nicola
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- 2024
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173. „Normale Mittel funktionieren bei Clusterkopfschmerz nicht!“
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Zink, Nicola
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- 2024
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174. Diäten beim Reizdarmsyndrom wirksamer als Medikamente
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Zink, Nicola
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- 2024
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175. Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.
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Mainali, Shraddha, Aiyagari, Venkatesh, Alexander, Sheila, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Brown, Emery, Brown, Jeremy, Claassen, Jan, Edlow, Brian, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Frontera, Jennifer, Geocadin, Romergryko, Giacino, Joseph, Gilmore, Emily, Gosseries, Olivia, Hammond, Flora, Helbok, Raimund, Claude Hemphill, J, Hirsch, Karen, Kim, Keri, Laureys, Steven, Lewis, Ariane, Ling, Geoffrey, Livesay, Sarah, McCredie, Victoria, McNett, Molly, Menon, David, Molteni, Erika, Olson, DaiWai, OPhelan, Kristine, Park, Soojin, Polizzotto, Len, Javier Provencio, Jose, Puybasset, Louis, Venkatasubba Rao, Chethan, Robertson, Courtney, Rohaut, Benjamin, Rubin, Michael, Sharshar, Tarek, Shutter, Lori, Sampaio Silva, Gisele, Smith, Wade, Stevens, Robert, Thibaut, Aurore, Vespa, Paul, Wagner, Amy, Ziai, Wendy, Zink, Elizabeth, and I Suarez, Jose
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Coma ,Curing Coma Campaign ,Disorders of consciousness ,National Institute of Health ,Proceedings ,Coma ,Consciousness ,Consciousness Disorders ,Humans ,National Institutes of Health (U.S.) ,United States - Abstract
This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we summarize the background, research priorities, panel discussions, and deliverables discussed during the symposium across six major domains related to disorders of consciousness. The six domains include (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, and (6) Long-term Recovery. Following the 1st Curing Coma NIH virtual symposium held on September 9 to September 10, 2020, six workgroups, each consisting of field experts in respective domains, were formed and tasked with identifying gaps and developing key priorities and deliverables to advance the mission of the Curing Coma Campaign. The highly interactive and inspiring presentations and panel discussions during the 3-day virtual NIH symposium identified several action items for the Curing Coma Campaign mission, which we summarize in this article.
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- 2022
176. Reframing microplastics as a ligand for metals reveals that water quality characteristics govern the association of cadmium to polyethylene
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Zink, Lauren, Mertens, Emily, Zhou, Xingzi, Johnston, Sarah Ellen, Bogard, Matthew, Wiseman, Steve, and Pyle, Gregory G.
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- 2024
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177. Failure Following Revision Total Hip Arthroplasty After Cobalt-Chrome Femoral Heads are Placed on a Retained Femoral Stem
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Pagani, Nicholas R., Coden, Gloria S., Ramsden, David M., Zink, Thomas M., Ward, Daniel M., Bono, James V., and Talmo, Carl T.
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- 2024
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178. Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study
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Gedde, Steven, Banitt, Michael, Budenz, Donald, Chang, Ta, Lee, Richard, Palmberg, Paul, Parrish, Richard, II, Swaminathan, Swarup, Vazquez, Luis, Wellik, Sarah, Werner, Mark, Zink, Jeffrey, Khatana, Anup, Grover, Davinder, Neelakantan, Arvind, Barton, Keith, Panarelli, Joseph, Sidoti, Paul, Tsai, James, Vinod, Kateki, Goyal, Saurabh, Lind, John, Shields, Steven, Lim, Kin Sheng, Brandt, James, Sherwood, Mark, Khaimi, Mahmoud, Sankar, Prithvi, Ansari, Husam, Miller-Ellis, Eydie, Feldman, Robert, Baker, Laura, Bell, Nicholas, Ahmed, Iqbal, Williams, Donna, Prum, Bruce, Ramulu, Pradeep, Jampel, Henry, Feuer, William, Londono, Luz, Schiffman, Joyce, Shi, Wei, Silva, Yolanda, Vanner, Elizabeth, Chen, Philip, Heuer, Dale, Singh, Kuldev, Wright, Martha, Swaminathan, Swarup S., Jammal, Alessandro A., Medeiros, Felipe A., and Gedde, Steven J.
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- 2024
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179. Perceived stress and associations between physical activity, sedentary time, and interstitial glucose in healthy adolescents
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McAlister, Kelsey L., Zink, Jennifer, Huh, Jimi, Yang, Chih-Hsiang, Dunton, Genevieve F., Dieli-Conwright, Christina M., Page, Kathleen A., and Belcher, Britni R.
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- 2024
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180. The effects of microplastics on ionoregulatory processes in the gills of freshwater fish and invertebrates: A prospective review
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Zink, Lauren and Wood, Chris M.
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- 2024
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181. Identifying differential predictors for treatment response to amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia: Results of the COMBINE-study
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Galuba, Viktoria, Cordes, Joachim, Feyerabend, Sandra, Riesbeck, Mathias, Meisenzahl-Lechner, Eva, Correll, Christoph U., Kluge, Michael, Neff, Andrea, Zink, Mathias, Langguth, Berthold, Reske, Dirk, Gründer, Gerhard, Hasan, Alkomiet, Brockhaus-Dumke, Anke, Jäger, Markus, Baumgärtner, Jessica, Leucht, Stefan, and Schmidt-Kraepelin, Christian
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- 2024
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182. Sulfur-substituted perylenediimides: Easy tunability of the electronic character
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Zink-Lorre, Nathalie, Font-Sanchis, Enrique, San-Fabián, Emilio, and Fernández-Lázaro, Fernando
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- 2024
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183. Solar flare observations with the Radio Neutrino Observatory Greenland (RNO-G)
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Agarwal, S., Aguilar, J.A., Ali, S., Allison, P., Betts, M., Besson, D., Bishop, A., Botner, O., Bouma, S., Buitink, S., Cataldo, M., Clark, B.A., Coleman, A., Couberly, K., de Kockere, S., de Vries, K.D., Deaconu, C., DuVernois, M.A., Glaser, C., Glüsenkamp, T., Hallgren, A., Hallmann, S., Hanson, J.C., Hendricks, B., Henrichs, J., Heyer, N., Hornhuber, C., Hughes, K., Karg, T., Karle, A., Kelley, J.L., Korntheuer, M., Kowalski, M., Kravchenko, I., Krebs, R., Lahmann, R., Latif, U., Laub, P., Liu, C.-H., Marsee, M.J., Meyers, Z.S., Mikhailova, M., Monstein, C., Mulrey, K., Muzio, M., Nelles, A., Novikov, A., Nozdrina, A., Oberla, E., Oeyen, B., Punsuebsay, N., Pyras, L., Ravn, M., Ryckbosch, D., Schlüter, F., Scholten, O., Seckel, D., Seikh, M.F.H., Stoffels, J., Terveer, K., Toscano, S., Tosi, D., Van Den Broeck, D.J., van Eijndhoven, N., Vieregg, A.G., Vijai, A., Welling, C., Williams, D.R., Windischhofer, P., Wissel, S., Young, R., and Zink, A.
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- 2025
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184. Comparing Different Approaches for Stellar Intensity Interferometry
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Karl, Sebastian, Zmija, Andreas, Richter, Stefan, Vogel, Naomi, Malyshev, Dmitry, Zink, Adrian, Michel, Thilo, Anton, Gisela, von Zanthier, Joachim, and Funk, Stefan
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Stellar intensity interferometers correlate photons within their coherence time and could overcome the baseline limitations of existing amplitude interferometers. Intensity interferometers do not rely on phase coherence of the optical elements and thus function without high grade optics and light combining delay lines. However, the coherence time of starlight observed with realistic optical filter bandwidths (> 0.1 nm) is usually much smaller than the time resolution of the detection system (> 10 ps), resulting in a greatly reduced correlation signal. Reaching high signal to noise in a reasonably short measurement time can be achieved in different ways: either by increasing the time resolution, which increases the correlation signal height, or by increasing the photon rate, which decreases statistical uncertainties of the measurement. We present laboratory measurements employing both approaches and directly compare them in terms of signal to noise ratio. A high time-resolution interferometry setup designed for small to intermediate size optical telescopes and thus lower photon rates (diameters < some meters) is compared to a setup capable of measuring high photon rates, which is planned to be installed at Cherenkov telescopes with dish diameters of > 10 m. We use a Xenon lamp as a common light source simulating starlight. Both setups measure the expected correlation signal and work at the expected shot-noise limit of statistical uncertainties for measurement times between 10 min and 23 h. We discuss the quantitative differences in the measurement results and give an overview of suitable operation regimes for each of the interferometer concepts., Comment: submitted to MNRAS
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- 2022
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185. In situ, broadband measurement of the radio frequency attenuation length at Summit Station, Greenland
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Aguilar, J. A., Allison, P., Beatty, J. J., Besson, D., Bishop, A., Botner, O., Bouma, S., Buitink, S., Cataldo, M., Clark, B. A., Curtis-Ginsberg, Z., Connolly, A., Dasgupta, P., de Kockere, S., de Vries, K. D., Deaconu, C., DuVernois, M. A., Glaser, C., Hallgren, A., Hallmann, S., Hanson, J. C., Hendricks, B., Hornhuber, C., Hughes, K., Karle, A., Kelley, J. L., Kravchenko, I., Krebs, R., Lahmann, R., Latif, U., Mammo, J., Meyers, Z. S., Michaels, K., Mulrey, K., Nelles, A., Novikov, A., Nozdrina, A., Oberla, E., Oeyen, B., Pan, Y., Pandya, H., Plaisier, I., Punsuebsay, N., Pyras, L., Ryckbosch, D., Scholten, O., Seckel, D., Seikh, M. F. H., Smith, D., Southall, D., Torres, J., Toscano, S., Tosi, D., Broeck, D. J. Van Den, van Eijndhoven, N., Vieregg, A. G., Welling, C., Williams, D. R., Wissel, S., Young, R., and Zink, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
Over the last 25 years, radiowave detection of neutrino-generated signals, using cold polar ice as the neutrino target, has emerged as perhaps the most promising technique for detection of extragalactic ultra-high energy neutrinos (corresponding to neutrino energies in excess of 0.01 Joules, or $10^{17}$ electron volts). During the summer of 2021 and in tandem with the initial deployment of the Radio Neutrino Observatory in Greenland (RNO-G), we conducted radioglaciological measurements at Summit Station, Greenland to refine our understanding of the ice target. We report the result of one such measurement, the radio-frequency electric field attenuation length $L_\alpha$. We find an approximately linear dependence of $L_\alpha$ on frequency with the best fit of the average field attenuation for the upper 1500 m of ice: $\langle L_\alpha \rangle = \big( (1154 \pm 121) - (0.81 \pm 0.14) (\nu/$MHz$)\big)$ m for frequencies $\nu \in [145 - 350]$ MHz., Comment: 13 pages, 8 figures, Accepted to Journal of Glaciology
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- 2022
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186. Polyline Simplification under the Local Fr\'echet Distance has Almost-Quadratic Runtime in 2D
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Storandt, Sabine and Zink, Johannes
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Computer Science - Computational Geometry - Abstract
Given a polyline on $n$ vertices, the polyline simplification problem asks for a minimum size subsequence of these vertices defining a new polyline whose distance to the original polyline is at most a given threshold under some distance measure, usually the local Hausdorff or the local Fr\'echet distance. Here, local means that, for each line segment of the simplified polyline, only the distance to the corresponding sub-curve in the original polyline is measured. Melkman and O'Rourke [Computational Morphology '88] introduced a geometric data structure to solve polyline simplification under the local Hausdorff distance in $O(n^2 \log n)$ time, and Guibas, Hershberger, Mitchell, and Snoeyink [Int. J. Comput. Geom. Appl. '93] considered polyline simplification under the Fr\'echet distance as ordered stabbing and provided an algorithm with a running time of $O(n^2 \log^2 n)$, but they did not restrict the simplified polyline to use only vertices of the original polyline. We show that their techniques can be adjusted to solve polyline simplification under the local Fr\'echet distance in $O(n^2 \log n)$ time instead of $O(n^3)$ when applying the Imai--Iri algorithm. Our algorithm may serve as a more efficient subroutine for multiple other algorithms. We provide a simple algorithm description as well as rigorous proofs to substantiate this theorem. We also investigate the geometric data structure introduced by Melkman and O'Rourke, which we refer to as wavefront, in more detail and feature some interesting properties. As a result, we can prove that under the L$_1$ and the L$_\infty$ norm, the algorithm can be significantly simplified and then only requires a running time of $O(n^2)$. We also define a natural class of polylines where our algorithm always achieves this running time also in the Euclidean norm L$_2$.
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- 2022
187. Large-scale plasma proteomics comparisons through genetics and disease associations
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Eldjarn, Grimur Hjorleifsson, Ferkingstad, Egil, Lund, Sigrun H., Helgason, Hannes, Magnusson, Olafur Th., Gunnarsdottir, Kristbjorg, Olafsdottir, Thorunn A., Halldorsson, Bjarni V., Olason, Pall I., Zink, Florian, Gudjonsson, Sigurjon A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Gisli H., Magnusson, Magnus K., Saevarsdottir, Saedis, Eiriksdottir, Thjodbjorg, Masson, Gisli, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorleifsson, Gudmar, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2023
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188. Markets and the Future of the Circular Economy
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Siderius, Thomas and Zink, Trevor
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- 2023
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189. Molekulargenetische Untersuchung einer Mumie
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Wurst, Christina, Sarhan, Mohamed Sabry, Maixner, Frank, and Zink, Albert
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- 2023
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190. Organspende nach assistiertem Suizid
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Dier, Helga, Friesenecker, Barbara, and Zink, Michael
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- 2023
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191. Investigation of Monte Carlo simulations of the electron transport in external magnetic fields using Fano cavity test
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Mohamad Alissa, Klemens Zink, and Damian Czarnecki
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Monte Carlo simulation ,Fano cavity test ,Detector ,Dosimetry in external magnetic fields ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Purpose: Monte Carlo simulations are crucial for calculating magnetic field correction factors kB for the dosimetry in external magnetic fields. As in Monte Carlo codes the charged particle transport is performed in straight condensed history (CH) steps, the curved trajectories of these particles in the presence of external magnetic fields can only be approximated. In this study, the charged particle transport in presence of a strong magnetic field B→ was investigated using the Fano cavity test. The test was performed in an ionization chamber and a diode detector, showing how the step size restrictions must be adjusted to perform a consistent charged particle transport within all geometrical regions. Methods: Monte Carlo simulations of the charged particle transport in a magnetic field of 1.5 T were performed using the EGSnrc code system including an additional EMF-macro for the transport of charged particle in electro-magnetic fields. Detailed models of an ionization chamber and a diode detector were placed in a water phantom and irradiated with a so called Fano source, which is a monoenergetic, isotropic electron source, where the number of emitted particles is proportional to the local density. Results: The results of the Fano cavity test strongly depend on the energy of charged particles and the density within the given geometry. By adjusting the maximal length of the charged particle steps, it was possible to calculate the deposited dose in the investigated regions with high accuracy (
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- 2023
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192. Determination of the dose rate around a HDR 192Ir brachytherapy source with the microDiamond and the microSilicon detector
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Giulio Rossi, Thomas Failing, Mark Gainey, Michael Kollefrath, Frank Hensley, Klemens Zink, and Dimos Baltas
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microDiamond ,microSilicon ,192Ir ,brachytherapy ,dosimetry ,Monte Carlo simulations ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Purpose: To employ the microDiamond and the microSilicon detector (mDD and mSD, both PTW-Freiburg, Germany) to determine the dose rate around a HDR 192Ir brachytherapy source (model mHDR-v2r, Elekta AB, Sweden).Methods: The detectors were calibrated with a 60Co beam at the PTW Calibration Laboratory. Measurements around the 192Ir source were performed inside a PTW MP3 water phantom. The detectors were placed at selected points of measurement at radial distances r, ranging from 0.5 to 10 cm, keeping the polar angle θ = 90°. Additional measurements were performed with the mSD at fixed distances r = 1, 3 and 5 cm, with θ varying from 0 to 150°, 0 to 166°, and 0 to 168°, respectively. The corresponding mDD readings were already available from a previous work (Rossi et al., 2020). The beam quality correction factor of both detectors, as well as a phantom effect correction factor to account for the difference between the experimental geometry and that assumed in the TG-43 formalism, were determined using the Monte Carlo (MC) toolkit EGSnrc. The beam quality correction factor was factorized into energy dependence and volume-averaging correction factors. Using the abovementioned MC-based factors, the dose rate to water at the different points of measurement in TG-43 conditions was obtained from the measured readings, and was compared to the dose rate calculated according to the TG-43 formalism.Results: The beam quality correction factor was considerably closer to unity for the mDD than for the mSD. The energy dependence of the mDD showed a very weak radial dependence, similar to the previous findings showing a weak angular dependence as well (Rossi et al., 2020). Conversely, the energy dependence of the mSD decreased significantly with increasing distances, and also showed a considerably more pronounced angular dependence, especially for the smallest angles. The volume-averaging showed a similar radial dependence for both detectors: the correction had a maximal impact at 0.5 cm and then approached unity for larger distances, as expected. Concerning the angular dependence, the correction for the mSD was also similar to the one previously determined for the mDD (Rossi et al., 2020): a maximal impact was observed at θ = 0°, with values tending to unity for larger angles. In general, the volume-averaging was less pronounced for the mSD due to the smaller sensitive volume radius. After the application of the MC-based factors, differences between mDD dose rate measurements and TG-43 dose rate calculations ranged from −2.6% to +4.3%, with an absolute average difference of 1.0%. For the mSD, the differences ranged from −3.1% to +5.2%, with an absolute average difference of 1.0%. For both detectors, all differences but one were within the combined uncertainty (k = 2). The differences of the mSD from the mDD ranged from −3.9% to +2.6%, with the vast majority of them being within the combined uncertainty (k = 2). For θ ≠ 0°, the mDD was able to provide sufficiently accurate results even without the application of the MC-based beam quality correction factor, with differences to the TG-43 dose rate calculations from −1.9% to +3.4%, always within the combined uncertainty (k = 2).Conclusion: The mDD and the mSD showed consistent results and appear to be well suitable for measuring the dose rate around HDR 192Ir brachytherapy sources. MC characterization of the detectors response is needed to determine the beam quality correction factor and to account for energy dependence and/or volume-averaging, especially for the mSD. Our findings support the employment of the mDD and mSD for source QA, TPS verification and TG-43 parameters determination.
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- 2023
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193. Extendible Functions and Local Root Numbers Remarks on a paper of R.P. Langlands
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Koch, Helmut and Zink, Ernst-Wilhelm
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Mathematics - Number Theory ,11S37, 11S20, 11S40, 20C15 - Abstract
This paper refers to Langlands' big set of notes [L] devoted to the question if the (normalized) local Hecke-Tate root number $\Delta=\Delta(E,\chi)$, where $E$ is a finite separable extension of a fixed non-archimedean local field $F$, and $\chi$ a quasicharacter of $E^\times$, can be appropriately extended to a local $\varepsilon$-factor $\varepsilon_\Delta=\varepsilon_\Delta(E,\rho)$ for all virtual representations $\rho$ of the corresponding Weil group $W_E.$ Whereas Deligne [D] has given a relatively short proof by using the global Artin-Weil L-functions, the proof of Langlands is purely local and splits into two parts: the {\bf algebraic part} to find a minimal set of relations for the functions $\Delta$, such that the existence (and uniqueness) of $\varepsilon_\Delta$ will follow from these relations; and the more extensive {\bf arithmetic part} to give a direct proof that all these relations are actually fulfilled. Our aim is to cover the algebraic part of Langlands' notes which can be done completely in the framework of representations of solvable profinite groups, where two modifications of Brauer's theorem play a prominent role. Introduction / 1. The notion of extendible functions / 2. The kernel of the Brauer map and its generating relations / 3. A criterion for the extendibility of functions / 4. Recovering Theorem 3.1 for the case of local root numbers / Appendices A1. Proving Brauer 3 and Brauer 4 / A2. On type-III-groups., Comment: 50 pages
- Published
- 2021
194. Minimizing the Risk of Diagnostic Errors in Acute Care for Older Adults: An Interdisciplinary Patient Safety Challenge
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Baker Nawfal Jawad, Kirstine Zink Pedersen, Ove Andersen, and Ninna Meier
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diagnostic errors ,clinical decision-making ,acute care ,interdisciplinary research ,Medicine - Abstract
Modern healthcare systems are increasingly organized according to diagnosis-specific clinical pathways and treatment protocols. At the same time, the number of patients with complex problems and needs that do not fit the single-diagnosis approach is rising, contributing to a high prevalence of diagnostic errors. In this article, we focus on the risk of diagnostic errors arising from missed or incomplete diagnosis and assessment of older adult patients’ care needs in the first hours of acute hospitalizations in EDs. This focus is important for improving patient safety, as clinical decisions made in EDs impact patient safety in the subsequent steps of the process, thereby potentially causing new risks to arise. Based on our discussion of clinical decision-making and diagnostic errors in the acute care context, we propose a more comprehensive interdisciplinary approach to improvements in patient safety that integrates organizational and clinical research and examines where, when, how, and why risks to patient safety arise in and across different clinical–organizational contexts.
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- 2024
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195. An Improved Bulk DNA Extraction Method for Detection of Helicoverpa armigera (Lepidoptera: Noctuidae) Using Real-Time PCR
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Kayla A. Mollet, Luke R. Tembrock, Frida A. Zink, Alicia E. Timm, and Todd M. Gilligan
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agriculture ,molecular diagnostics ,caffeine ,invasive species ,food security ,old world bollworm ,Science - Abstract
Helicoverpa armigera is among the most problematic agricultural pests worldwide due to its polyphagy and ability to evolve pesticide resistance. Molecular detection methods for H. armigera have been developed to track its spread, as such methods allow for rapid and accurate differentiation from the native sibling species H. zea. Droplet digital PCR (ddPCR) is a preferred method for bulk screening due to its accuracy and tolerance to PCR inhibitors; however, real-time PCR is less expensive and more widely available in molecular labs. Improvements to DNA extraction yield, purity, and throughput are crucial for real-time PCR assay optimization. Bulk DNA extractions have recently been improved to where real-time PCR sensitivity can equal that of ddPCR, but these new methods require significant time and specialized equipment. In this study, we improve upon previously published bulk DNA extraction methods by reducing bench time and materials. Our results indicate that the addition of caffeine and RNase A improves DNA extraction, resulting in lower Cq values during real-time PCR while reducing the processing time and cost per specimen. Such improvements will enable the use of high throughput screening methods across multiple platforms to improve the probability of detection of H. armigera.
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- 2024
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196. Hyperhidrose und Hochstapler-Syndrom: eine häufige Kombination
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Zink, Nicola
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- 2024
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197. Biomarker - wichtige Indikatoren für Asthma
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Zink, Nicola
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- 2024
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198. Klimawandel geht unter die Haut
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Traidl-Hoffmann, Claudia, John, Swen Malte, and Zink, Alexander
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- 2024
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199. Gesture-Speech Integration Is Related to Vocabulary Skills in Children with Developmental Language Disorder, Williams Syndrome and Typical Development
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Rombouts, Ellen, Leenen, Liesl, Maes, Bea, and Zink, Inge
- Abstract
Background: Individuals with developmental language disorder or Williams syndrome are reported to use more gestures than individuals with typical development. However, these two groups differ considerably in visuospatial and language skills, two skills that are hypothesized to shape gesture rate. Aims: We first examined whether children with both developmental language disorder and children Williams syndrome do indeed use more gestures. Our second aim was to disentangle the role of vocabulary and visuospatial skills in the use of supplementary gestures (i.e., containing unique information). To account for participant heterogeneity, analyses included both group comparisons and vocabulary and visuospatial skills at an individual level. As a third aim, the role of visuospatial skills was further examined in relation to gestures containing spatial content. Methods & Procedures: In a cross-sectional group design, three participant groups watched and then retold a cartoon--children with typical development (n = 25), children with developmental language disorder (n = 25) and children/young people with Williams syndrome (n = 14). Their narrations were transcribed and hand gestures were coded based on gesture-speech integration (redundant, adds information to particular lexical items, gives information that is entirely absent from speech) and spatial content. Participants' expressive vocabulary and visuospatial skills were measured. Outcomes & Results: Between-group comparisons showed that individuals with developmental language disorder or Williams syndrome did indeed use more gestures. Poisson loglinear modelling demonstrated that a relative higher use of supplementary gestures was determined by lower expressive vocabulary skills. Neither the group distinction nor visuospatial skills shaped the supplementary gesture rate nor spatial gesture rate. Conclusions & Implications: Regardless of neurodevelopmental condition or typical development, a higher use of supplementary gestures was influenced by expressive vocabulary skills. Children with lower vocabulary skills spontaneously capitalized on the multimodality of communication to express constituents that were not present in their verbal speech. This finding is a promising starting point for future gesture intervention studies examining whether implicit modelling of gesture use can encourage gestures even more in these children and if this allows them to achieve higher linguistic complexity. On a methodological note, the observed intra-group skill variability demonstrates that group comparisons need to be complemented with correlational measures accounting for skills at an individual level.
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- 2023
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200. Measuring the Startup Journey and Academic Productivity of New Research Faculty through Systems Engagement, Project Efficiency, and Scientific Publication
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Zink, Holly R. and Curran, Jack D.
- Abstract
Little is known about the process of tracking the activity and days-to-productivity of new research faculty in pediatric academic medical centers in the United States. The purpose of this study was to design a quantitative technique for measuring the startup journey and academic productivity of new research faculty at an established research academic medical center. Three measures, (1) engagement, (2) efficiency, and (3) publication, were used to identify the total number of days that it takes for a new research faculty member to move from the discovery phase (value-consumed) into the engagement phase (value-created) after accepting a new position. General findings were that the typical research faculty member hired from 2014 to 2018 at Children's Mercy was male, submitted his first research project within the first three months of employment and averaged one new research submission per year. He would collaborate on a publication as a co-author within the first six months of employment, his first primary author publication would be published near his first employment anniversary, and he would average 2.9 publications per year in the first few years. The current study hopes to fill a gap in existing literature regarding the best practices for tracking, reporting and comparing the startup journey and academic productivity of new research faculty in pediatric academic medical centers.
- Published
- 2020
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