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594 results on '"Zhao, Zhenjiang"'

155. Low-speed wind turbine design based on Wilson theory

Author

Zhao Zhenjiang, Hu Danmei, and Chen Yunhao

Subjects
Wind power, Turbine blade, business.industry, Aerodynamics, Turbine, Wind speed, Renewable energy, law.invention, Pitch control, law, Wind turbine design, Environmental science, business, Marine engineering
Abstract

As a clean and renewable energy with huge reserves, wind energy has been widely developed and utilized worldwide. Wind turbine blades are one of the main components of wind power generation. The degree of conversion of wind energy by the blades can determine the efficiency of the wind turbine. This paper aims to optimize the design of low-speed wind turbine blades with a rated power of 600 kW and an average wind speed of 4.3 m/s at the hub height. Wind turbines use variable speed and pitch control to determine the design parameters of the wind turbine. We choose an airfoil with good aerodynamic performance at low wind speeds. The Wilson design method is used to calculate the chord length, torsion angle and other parameters of each segment of the blade, complete the preliminary shape design of the low-speed blade, and calculate its aerodynamic performance.

Published
2021

157. ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2

Author

Zhiping Guo, Wang Chuanzhen, Junyan Teng, Jitian Li, Jun Wu, Yanxing Guo, Zhao Zhenjiang, Su Xiaochuan, Jin Guoguo, Xiangyang Cao, Qing Guo, Guo Malong, and Li Xiaoling

Subjects
0301 basic medicine, Adult, Male, ELK1, Proliferation, Bone Neoplasms, RM1-950, Biology, MIR100HG, Protein Serine-Threonine Kinases, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Gene silencing, Humans, Hippo signaling pathway, ets-Domain Protein Elk-1, Pharmacology, Osteosarcoma, Oncogene, Cell growth, Tumor Suppressor Proteins, General Medicine, Middle Aged, medicine.disease, Long non-coding RNA, Up-Regulation, MicroRNAs, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Disease Progression, Female, RNA, Long Noncoding, Therapeutics. Pharmacology
Abstract

Osteosarcoma (OS) is the commonest malignant bone tumor in the world. High incidence of OS has gradually become a social problem. Recent years, numerous studies have revealed that long non-coding RNAs (lncRNAs) are crucial regulators in the tumor progression. As a member of lncRNA family, MIR100HG has been reported to be an oncogene in breast cancer and acute megakaryoblastic leukemia. Nevertheless, the specific role of MIR100HG in osteosarcoma is still unclear. In this study, we investigated the biological function and molecular mechanism of MIR100HG in the progression of osteosarcoma. At first, we measured the high expression of MIR100HG in OS tissues and cell lines by qRT-PCR. Kaplan-Meier method revealed that high expression of MIR100HG is a factor for the poor prognosis of OS patients (P = 0.004). To explore the effect of MIR100HG on the biological processes of OS, loss-of-function assays were conducted in OS cells. Functionally, MIR100HG knockdown suppressed cell proliferation, cell cycle progression while promoted cell apoptosis. Mechanistically, MIR100HG was upregulated by the transcription factor ELK1. The upregulation of MIR100HG led to the inactivation of Hippo pathway. Furthermore, we found that MIR100HG inactivated Hippo pathway in OS cells by epigenetically silencing LATS1 and LATS2. Rescue assays demonstrated that LATS1/2 involved in MIR100HG-mediated OS progression. In summary, our study indicated that ELK1-induced upregulation of MIR100HG promoted OS progression by epigenetically silencing LATS1 and LATS2 and inactivating Hippo pathway.

Published
2018

160. Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton’s tyrosine kinase inhibitors

Author

Diao, Yanyan, primary, Fang, Xiaoyu, additional, Song, Peiran, additional, Lai, Mengzhen, additional, Tong, Linjiang, additional, Hao, Yongjia, additional, Dou, Dou, additional, Liu, Yingqiang, additional, Ding, Jian, additional, Zhao, Zhenjiang, additional, Xie, Hua, additional, and Li, Honglin, additional

Published
2019
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164. Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S

Author

Li, Qiannan, primary, Zhang, Tao, additional, Li, Shiliang, additional, Tong, Linjiang, additional, Li, Junyu, additional, Su, Zhicheng, additional, Feng, Fang, additional, Sun, Deheng, additional, Tong, Yi, additional, Wang, Xia, additional, Zhao, Zhenjiang, additional, Zhu, Lili, additional, Ding, Jian, additional, Li, Honglin, additional, Xie, Hua, additional, and Xu, Yufang, additional

Published
2019
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165. Correction to Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes

Author

Li, Shiliang, primary, Qin, Chun, additional, Cui, Shichao, additional, Xu, Hongling, additional, Wu, Fangshu, additional, Wang, Jiawei, additional, Su, Mingbo, additional, Fang, Xiaoyu, additional, Li, Dan, additional, Jiao, Qian, additional, Zhang, Ming, additional, Xia, Chunmei, additional, Zhu, Lili, additional, Wang, Rui, additional, Li, Jia, additional, Jiang, Hualiang, additional, Zhao, Zhenjiang, additional, Li, Jingya, additional, and Li, Honglin, additional

Published
2019
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169. Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes

Author

Li, Shiliang, primary, Qin, Chun, additional, Cui, Shichao, additional, Xu, Hongling, additional, Wu, Fangshu, additional, Wang, Jiawei, additional, Su, Mingbo, additional, Fang, Xiaoyu, additional, Li, Dan, additional, Jiao, Qian, additional, Zhang, Ming, additional, Xia, Chunmei, additional, Zhu, Lili, additional, Wang, Rui, additional, Li, Jia, additional, Jiang, Hualiang, additional, Zhao, Zhenjiang, additional, Li, Jingya, additional, and Li, Honglin, additional

Published
2019
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173. Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors.

Author

Luo, Na, Fang, Xiaoyu, Su, Mingbo, Zhang, Xinwen, Li, Dan, Li, Honglin, Li, Shiliang, and Zhao, Zhenjiang

Subjects
CD26 antigen, PEPTIDASE, TYPE 2 diabetes
Abstract

Main observation and conclusion: Dipeptidyl peptidase 4 (DPP‐4) is a clinically validated target for the treatment of type 2 diabetes mellitus (T2DM). To discover novel and potent DPP‐4 inhibitors, three series of compounds were designed and synthesized in this study based on our previously identified novel scaffold of 2‐phenyl‐3,4‐dihydro‐2H‐benzo[f]chromen‐3‐amine. Among the designed compounds, 41d‐1 was the most potent one with an IC50 value of 16.00 nM. Besides, 41d‐1 (5 mg/kg) displayed a moderate glucose tolerance capability in ICR mice. Structure‐activity‐relationship (SAR) studies were discussed in detail, which is constructive for our further optimization. [ABSTRACT FROM AUTHOR]

Published
2021
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174. Stability criterion in Lagrange sense for complex-valued neural networks with mixed time-varying delays

Author

Song Qian-kun and Zhao Zhenjiang

Subjects
0209 industrial biotechnology, Artificial neural network, Stability criterion, Complex valued, 02 engineering and technology, Sense (electronics), Linear matrix, Matrix (mathematics), 020901 industrial engineering & automation, Exponential stability, Control theory, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, MATLAB, computer, computer.programming_language, Mathematics
Abstract

In this paper, the global exponential stability in Lagrange sense for complex-valued neural networks with discrete time-varying delays and distributed time-varying delays is investigated. A criterion to ensure the global exponential stability in Lagrange sense for complex-valued neural networks with discrete time-varying delays and distributed time-varying delays is obtained by employing Lyapunov-Krasovskii functional and using free-weighting-matrix approach and matrix inequality techniques. The condition is expressed in complex-valued linear matrix inequalities, which can be checked numerically using the effective YALMIP toolbox in MATLAB.

Published
2017

175. Abstract 4292: Molecular mechanism of APIO-EE-7 suppresses cell metastasis by targeting Aurora B in osteosarcoma

Author

Li Xiaoling, Zhao Zhenjiang, Zhiping Guo, Jitian Li, Jin Guoguo, and Teng Junyan

Subjects
Cancer Research, biology, business.industry, Cell, Aurora B kinase, Cancer, Vimentin, medicine.disease, Metastasis, medicine.anatomical_structure, Aurora kinase, Oncology, Survivin, biology.protein, Cancer research, Medicine, Osteosarcoma, business
Abstract

Osteosarcoma is one of the most prevalent malignant bone tumors in children and adolescents and has the characteristics of early metastasis, rapid progression and poor prognosis. Although with the advancement in techniques and treatment increasing the survival rates up to 60%, the prognosis remains poor for most patients with metastatic or recurrent osteosarcoma. Identifying the molecular mechanism and developing therapeutic agents for metastasis is urgent. Aurora B kinase play a key role in mitosis and have been reported to be associated with cancer metastasis. However, the role of Aurora kinase in osteosarcoma is still unclear. In this study, we identified a novel compound, referred to as APIO-EE-7, which inhibits growth and colony formation and induces apoptosis in osteosarcoma. Using computer modeling, we found that APIO-EE-7 can interact with Aurora B at ATP-binding pocket. Treatment with APIO-EE-7 can increase EMT marker expression level of E-cadherin and decrease N-cadherin, vimentin and survivin expression. Importantly, APIO-EE-7 dramatically attenuated tumor incidence and volume in osteosarcoma metastasis mouse model. Our findings suggest that APIO-EE-7 is a potential therapeutic agent against osteosarcoma metastasis by targeting Aurora B, which provides hope for rapid clinic translation. Citation Format: Guoguo Jin, Jitian Li, Zhiping Guo, Junyan Teng, Xiaoling Li, Zhenjiang Zhao. Molecular mechanism of APIO-EE-7 suppresses cell metastasis by targeting Aurora B in osteosarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4292.

Published
2019

179. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

Author

Hao, Yongjia, primary, Lyu, Jiankun, additional, Qu, Rong, additional, Tong, Yi, additional, Sun, Deheng, additional, Feng, Fang, additional, Tong, Linjiang, additional, Yang, Tingyuan, additional, Zhao, Zhenjiang, additional, Zhu, Lili, additional, Ding, Jian, additional, Xu, Yufang, additional, Xie, Hua, additional, and Li, Honglin, additional

Published
2018
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184. Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors

Author

Chen, Haiyang, primary, Song, Peiran, additional, Diao, Yanyan, additional, Hao, Yongjia, additional, Dou, Dou, additional, Wang, Wanqi, additional, Fang, Xiaoyu, additional, Wang, Yanling, additional, Zhao, Zhenjiang, additional, Ding, Jian, additional, Li, Honglin, additional, Xie, Hua, additional, and Xu, Yufang, additional

Published
2018
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185. Aurora B Kinase as a Novel Molecular Approach for Osteosarcoma Therapy

Author

Zhao, Zhenjiang, primary, Jin, Guoguo, additional, Yao, Ke, additional, Liu, Kangdong, additional, Liu, Fangfang, additional, Chen, Hanyong, additional, Wang, Keke, additional, Gorja, Dhilli Rao, additional, Reddy, Kanamata, additional, Bode, Ann M., additional, Guo, Zhiping, additional, and Dong, Zigang, additional

Published
2018
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198. Stabilization of chaotic neural networks with time-varying delays via non-periodically intermittent control

Author

Zhao Zhenjiang and Song Qian-kun

Subjects
Nonlinear Sciences::Chaotic Dynamics, Control period, Matrix (mathematics), Artificial neural network, Control theory, Chaotic neural network, Intermittent control, Linear matrix inequality, Differentiable function, Stability (probability), Mathematics
Abstract

In this paper, a class of chaotic neural networks with time-varying delays are considered without assuming the differentiability of the time-varying delays, and the stabilization for the considered neural networks is investigated via intermittent control with non-fixed both control period and control width. A delay-dependent criterion for checking the stabilization of the neural networks are presented by employing Lyapunov-Krasovskii functional and using the matrix inequality techniques. The obtained results extend ones on stabilization of delayed neural networks by periodically intermittent control with both fixed control period and control width. An example with simulations is given to show the effectiveness of the obtained results.

Published
2015

199. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Author

Xiong, Rui, Zhang, Leike, Li, Shiliang, Sun, Yuan, Ding, Minyi, Wang, Yong, Zhao, Yongliang, Wu, Yan, Shang, Weijuan, Jiang, Xiaming, Shan, Jiwei, Shen, Zihao, Tong, Yi, Xu, Liuxin, Chen, Yu, Liu, Yingle, Zou, Gang, Lavillete, Dimitri, Zhao, Zhenjiang, Wang, Rui, Zhu, Lili, Xiao, Gengfu, Lan, Ke, Li, Honglin, and Xu, Ke

Abstract

Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we identified two potent inhibitors of human DHODH, S312 and S416, with favorable drug-likeness and pharmacokinetic profiles, which all showed broad-spectrum antiviral effects against various RNA viruses, including influenza A virus, Zika virus, Ebola virus, and particularly against SARS-CoV-2. Notably, S416 is reported to be the most potent inhibitor so far with an EC50of 17 nmol/L and an SI value of 10,505.88 in infected cells. Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivoand low virus replication in DHODH knock-out cells. This work demonstrates that both S312/S416 and old drugs (Leflunomide/Teriflunomide) with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide, no matter such viruses are mutated or not.

Published
2020
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200. In situ synthesis of porous LiNi0.5Co0.2Mn0.3O2 tubular-fiber as high-performance cathode materials for Li-ion batteries.

Author

Zhang, Linsen, Zhao, Zhenjiang, Cao, Yang, Wang, Lizhen, Fang, Hua, Gao, Kezheng, Zhang, Aiqin, Gao, Haili, and Song, Yanhua

Abstract

Hollow structural materials exhibit strong advantages for application in electrode materials. Herein, we report an in situ synthesis of hollow tubular-fiber LiNi0.5Co0.2Mn0.3O2 (HFNCM523) prepared via electrospinning combined with calcination. The features of this material were provided with fiber-interconnected 3D network structure, hollow tubular structure, and multi-scale particle gaps, which are evenly distributed on the fiber's surface. The multiple synergistic effects of these advantages result in the remarkably excellent electrochemical performance of the tubular-fiber structures with a high specific capability of 191.2 mAh g−1 at 0.1 C and 84% high rate capacity retention after 100 cycles at 1 C. In particular, the LiNi0.5Co0.2Mn0.3O2 hollow tubular-fiber structure was well maintained after 100 cycles. [ABSTRACT FROM AUTHOR]

Published
2019
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