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1,283 results on '"Zhao, Jinmin"'

167. Onc201 reduces osteoclastogenesis and prevents ovariectomy-induced bone loss via inhibiting RANKL-induced NFATc1 activation and the integrin signaling pathway

Author

Wu, Liwei, primary, Liang, Jiamin, additional, Li, Jing, additional, Xu, Yang, additional, Chen, Junchun, additional, Su, Yuangang, additional, Xian, Yansi, additional, Wei, Jiyong, additional, Xu, Jiake, additional, Zhao, Jinmin, additional, Liu, Qian, additional, and Yang, Yuan, additional

Published
2022
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174. Berberine enhances the radiosensitivity of osteosarcoma by targeting Rad51 and epithelial-mesenchymal transition

Author

Wang, Dapeng, Zhang, Ke, Du, Gang, Wang, Jun, and Zhao, Jinmin

Subjects
Becton, Dickinson and Co., Osteosarcoma, Ionizing radiation, Medical equipment industry, Stem cells, Radiotherapy, Tumors, Cell cycle, Health
Abstract

Byline: Dapeng. Wang, Ke. Zhang, Gang. Du, Jun. Wang, Jinmin. Zhao Objective: Osteosarcoma is a malignant bone tumor and is generally treated with radiotherapy combined with radiosensitizers. The aim of [...]

Published
2020

175. Additional file 1 of PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment

Author

Liang, Ruiming, Yang, Xingchen, Yew, Pek Yin Michelle, Sugiarto, Sigit, Zhu, Qiang, Zhao, Jinmin, Loh, Xian Jun, Zheng, Li, and Kai, Dan

Abstract

Additional file1: Table S1. Table characterization of lignin-g-PLA copolymers. Table S2. TGA characterisation table of PLLA and PLLA/PLA-lignin nanofibers. Figure S1. 1H NMR (CDCl3) of the synthesized alkylated lignin. Figure S2. 1H NMR (CDCl3) of the alkylated lignin-g-PLA. Figure S3. FTIR spectra of lignin and PLA-lignin copolymers. Figure S4. Images showing the water contact angles of PLLA and PLLA/PLA-lignin nanofibers. Figure S5. Typical stress-strain curves of the PLLA/PLA-lignin nanofibers by tensile test. Figure S6. DSC curves of PLA-lignin copolymers. Figure S7. DSC curves of PLLA/lignin-PLA nanofibers.

Published
2022
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176. Geometric and Electronic Structure‐Matched Superoxide Dismutase‐Like and Catalase‐Like Sequential Single‐Atom Nanozymes for Osteoarthritis Recession.

Author

Zhong, Jingping, Yang, Xin, Gao, Shangzhi, Luo, Ji, Xiang, Jianhui, Li, Guanhua, Liang, Yanling, Tang, Lijuan, Qian, Cheng, Zhou, Jing, Zheng, Li, Zhang, Kun, and Zhao, Jinmin

Subjects
SYNTHETIC enzymes, NITROXIDES, CATALYTIC activity, SUPEROXIDE dismutase, SUPEROXIDES, OSTEOARTHRITIS, REACTIVE oxygen species
Abstract

Highly‐active single‐atom nanoenzymes (SAzymes) with biomimetic geometric and electronic coordination structures are highly highlighted to exhibit greatly‐increased catalysis activity. Despite various SAzymes, superoxide dismutase (SOD)‐like SAzymes for scavenging superoxide anions to treat osteoarthritis are still absent. In this report, a graphene‐supported ClCuN4‐centered SAzyme (CuN4ClG) is engineered that carries out SOD‐like reactions. Various synchrotron radiation‐based X‐ray valence/structural analyses reveal that the geometric and electronic structures of such ClCuN4 active centers are validated to atomically match natural SOD enzyme after precisely manipulating coordinated N and Cl atoms via the unprecedented pre‐coordination orientation and preservation of copper‐phthalocyanine structure. Cu‐N4ClG SAzymes are endowed with unparalleled catalytic activities and kinetics to degrade O2•¯ into H2O2 and O2, and further exhibit catalase (CAT)‐like activity to sequentially decompose H2O2 and •OH into H2O and O2, wherein the origin of sequential SOD‐like and CAT‐like catalysis routes is uncovered. Impressively, nitroxide radical scavenging and photothermally‐enhanced catalytic activity are reached, synergistically protecting chondrocytes from oxidative stress‐induced apoptosis and alleviating osteoarthritis via re‐programming or normalizing osteoarthritis microenvironments. Cu‐N4ClG SAzymes are competent for other reactive oxygen species (ROS)‐arised lesions, and their rationales provide guidance to design other SAzymes. [ABSTRACT FROM AUTHOR]

Published
2023
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177. Mitochondrial-targeting Mn3O4/UIO-TPP nanozyme scavenge ROS to restore mitochondrial function for osteoarthritis therapy.

Author

Zhang, Shengqing, Cai, Jinhong, Yao, Yi, Huang, Lanli, Zheng, Li, and Zhao, Jinmin

Subjects
MITOCHONDRIAL membranes, ANTERIOR cruciate ligament, OSTEOARTHRITIS, MITOCHONDRIA, HYDROXYL group, REACTIVE oxygen species
Abstract

Excessive reactive oxygen species (ROS)-induced mitochondrial damage has impact on osteoarthritis (OA). Nanozyme mimics as natural enzyme alternatives to scavenge excessive ROS has offered a promising strategy for OA therapy. Herein, we reported a novel mitochondrial-targeting Mn3O4/UIO-TPP nanozyme using metal-organic frameworks with loaded Mn3O4 as the enzyme-like active core combining mitochondria-targeting triphenylphosphine (TPP) groups to serve as ROS scavengers for therapy of OA. With sequential catalysis of superoxide dismutase-like, catalase (CAT)-like, and hydroxyl radical (·OH) scavenging potentials, the nanozyme can target mitochondria by crossing subcellular barriers to effectively eliminate ROS to restore mitochondrial function and inhibit inflammation and chondrocyte apoptosis. It also has favorable biocompatibility and biosafety. Based on anterior cruciate ligament transection-induced OA joint models, this mitochondrial-targeting nanozyme effectively mitigated the inflammatory response with the Pelletier score reduction of 49.9% after 8-week therapy. This study offers a prospective approach to the design of nanomedicines for ROS-related diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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178. The mechanism of the Nfe2l2/Hmox1 signaling pathway in ferroptosis regulation in acute compartment syndrome.

Author

Zheng, Tiejun, Huang, Zhao, Ling, He, Li, Junfeng, Cheng, Hong, Chen, Dingquan, Lu, Qinzhen, Zhao, Jinmin, and Su, Wei

Subjects
COMPARTMENT syndrome, CELLULAR signal transduction, HEME oxygenase, WESTERN immunoblotting, ORTHOPEDIC shoes, GLUTATHIONE peroxidase, EPICATECHIN
Abstract

Acute compartment syndrome (ACS) is a life‐threatening orthopedic emergency, which can even result in amputation. Ferroptosis is an iron‐dependent form of nonapoptotic cell death. This study investigated the mechanism of ferroptosis in ACS, explored candidate markers, and determined effective treatments. This study identified pathways involved in the development of ACS through gene set enrichment analysis (GSEA), Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and GSEA of heme oxygenase 1 (Hmox1). Bioinformatics methods, combined with real‐time quantitative polymerase chain reaction, western blot analysis, and iron staining, were applied to determine whether ferroptosis was involved in the progression of ACS and to explore the mechanism of nuclear factor erythroid‐2‐related factor 2 (Nfe2l2)/Hmox1 in ferroptosis regulation. Optimal drugs for the treatment of ACS were also investigated using Connectivity Map. The ferroptosis pathway was enriched in GSEA, KEGG of DEGs, and GSEA of Hmox1. After ACS, the reactive oxygen species content, tissue iron content, and oxidative stress level increased, whereas glutathione peroxidase 4 protein expression decreased. The skeletal muscle was swollen and necrotized; the number of mitochondrial cristae became fewer or even disappeared, and Nfe2l2/Hmox1 expression increased at the transcriptional and protein levels. Hmox1 was highly expressed in ACS, indicating that Hmox1 is a possible marker for ACS. we could predict 12 potential target drugs for the treatment of ACS. In conclusion, Hmox1 was a potential candidate marker for ACS diagnosis. Ferroptosis was involved in the progression of ACS. It was speculated that ferroptosis is inhibited by the Nfe2l2/Hmox1 signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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182. Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling

Author

Wu, Zuoxing, primary, Li, Chen, additional, Chen, Yu, additional, Liu, Qian, additional, Li, Na, additional, He, Xuemei, additional, Li, Weibin, additional, Shen, Rong, additional, Li, Li, additional, Wei, Chenming, additional, Shao, Siyuan, additional, Fu, Fangsheng, additional, Ding, Jiaxin, additional, Sun, Xiaochen, additional, Wang, Dairong, additional, Yuan, Guixin, additional, Su, Yiji, additional, Zhao, Jinmin, additional, Xu, Jiake, additional, Xu, Ren, additional, Xu, Xin, additional, and Xu, Feng, additional

Published
2022
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184. Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis

Author

Huang, Linke, primary, Chen, Weiwei, additional, Wei, Linhua, additional, Su, Yuangang, additional, Liang, Jiamin, additional, Lian, Haoyu, additional, Wang, Hui, additional, Long, Feng, additional, Yang, Fan, additional, Gao, Shiyao, additional, Tan, Zhen, additional, Xu, Jiake, additional, Zhao, Jinmin, additional, and Liu, Qian, additional

Published
2022
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