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153. Table S1 - Table S9 from Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma

Author

Peng, Li, primary, Jiang, Binyuan, primary, Yuan, Xiaoqing, primary, Qiu, Yuntan, primary, Peng, Jiangyun, primary, Huang, Yongsheng, primary, Zhang, Chaoyang, primary, Zhang, Yin, primary, Lin, Zhaoyu, primary, Li, Jinsong, primary, Yao, Weicheng, primary, Deng, Weixi, primary, Zhang, Yaqin, primary, Meng, Meng, primary, Pan, Xi, primary, Li, Chunquan, primary, Yin, Dong, primary, Bi, Xinyu, primary, Li, Guancheng, primary, and Lin, De-Chen, primary

Published
2023
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154. Figure S1 - S14 from Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma

Author

Peng, Li, primary, Jiang, Binyuan, primary, Yuan, Xiaoqing, primary, Qiu, Yuntan, primary, Peng, Jiangyun, primary, Huang, Yongsheng, primary, Zhang, Chaoyang, primary, Zhang, Yin, primary, Lin, Zhaoyu, primary, Li, Jinsong, primary, Yao, Weicheng, primary, Deng, Weixi, primary, Zhang, Yaqin, primary, Meng, Meng, primary, Pan, Xi, primary, Li, Chunquan, primary, Yin, Dong, primary, Bi, Xinyu, primary, Li, Guancheng, primary, and Lin, De-Chen, primary

Published
2023
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161. First principles study of B7N5 as a high capacity electrode material for K-ion batteries.

Author

Xiong, Yu, Wang, Yuhang, Ma, Ninggui, Zhang, Yaqin, Luo, Shuang, and Fan, Jun

Abstract

Potassium-ion batteries (KIBs) are considered a promising candidate for energy storage owing to their low cost and similar "rocking chair" mechanism to lithium-ion batteries. However, there is a great lack of suitable and high working performance electrode materials for KIBs. Herein, first principles calculations based on density functional theory (DFT) are applied to evaluate the potential of the B7N5 monolayer as an anode material for KIBs. It is found that B7N5 shows negative adsorption energies for Li/Na/K on its surface. Besides, the B7N5 monolayer can effectively achieve double-layer adsorption for K atoms on both sides of the monolayer surface, while one-layer adsorption for Li and Na. Thus, B7N5 exhibits an ultra-high theoretical capacity of 1471.5 mA h g−1 for KIBs, which is almost the highest value for the anode materials reported in the literature. And the attractive capacity for KIBs is mainly contributed by the multiple empty electron orbitals of the constituting elements of B7N5 and the small distance mismatch. In addition, K atoms display high diffusivities on B7N5 with low energy barriers of 0.10 eV, and the open circuit voltages of 0.14 V for KIBs are also smaller compared with previous research. It is also shown that after adsorbing K, the semiconducting B7N5 monolayer is transformed to a metallic state with good conductivity. Furthermore, despite the large size of K+, the maximum change in the lattice constant of B7N5 is only 1.32%, indicating structural stability and ensuring good cycling stability for KIBs. The above-mentioned results suggest that B7N5 is a potential anode material for KIBs. [ABSTRACT FROM AUTHOR]

Published
2023
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165. Long-term pegylated growth hormone for children with growth hormone deficiency: a large, prospective, real-world study

Author

Hou, Ling, primary, Huang, Ke, additional, Gong, Chunxiu, additional, Luo, Feihong, additional, Wei, Haiyan, additional, Liang, Liyang, additional, Du, Hongwei, additional, Zhang, Jianping, additional, Zhong, Yan, additional, Chen, Ruimin, additional, Chen, Xinran, additional, Pan, Jiayan, additional, Jin, Xianjiang, additional, Zeng, Ting, additional, Liao, Wei, additional, Liu, Deyun, additional, Lan, Dan, additional, Zhu, Shunye, additional, Dong, Zhiya, additional, Ma, Huamei, additional, Yang, Yu, additional, Xiong, Feng, additional, MB, Ping Lu, additional, Cheng, Shengquan, additional, Gu, Xuefan, additional, Jin, Runming, additional, Liu, Yu, additional, Wu, Jinzhun, additional, Xu, Xu, additional, Chen, Linqi, additional, Dong, Qin, additional, Pan, Hui, additional, Su, Zhe, additional, Liu, Lijun, additional, Luo, Xiaoming, additional, Ni, Shining, additional, Chen, Zhihong, additional, Hu, Yuhua, additional, Wang, Chunlin, additional, Liu, Jing, additional, Liu, Li, additional, Lu, Biao, additional, Wang, Xinli, additional, Wang, Yunfeng, additional, Yang, Fan, additional, Zhang, Manyan, additional, Cao, Lizhi, additional, Liu, GeLi, additional, Yao, Hui, additional, Zhang, Yaqin, additional, Dai, Mingjuan, additional, Li, Guimei, additional, Li, Li, additional, Liu, Yanjie, additional, Wang, Kan, additional, Xiao, Yanfeng, additional, Zhang, Xingxing, additional, Dong, Junhua, additional, Gu, Zaiyan, additional, Ying, Lirong, additional, Huang, Feng, additional, Liu, Yanling, additional, Liu, Zheng, additional, Ye, Jin, additional, Zhao, Dongmei, additional, Hu, Xu, additional, Jiang, Zhihong, additional, Ye, Kan, additional, Zhu, Hong, additional, Chen, Shaoke, additional, Chen, Xiaobo, additional, Wan, Naijun, additional, Xu, Zhuangjian, additional, Yin, Qingjin, additional, Zhang, Hongxiao, additional, Huang, Xiaodong, additional, Yin, Jianying, additional, Zhang, Huifeng, additional, Li, Pin, additional, Yin, Ping, additional, Fu, Junfen, additional, and Luo, XiaoPing, additional

Published
2023
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169. Immiscible phase-separation electrolyte and interface ion transfer electrochemistry enable zinc/lithium hybrid batteries with 3.5 V-class operating voltage

Author

Chen, Ao, primary, Zhang, Yaqin, additional, Li, Qing, additional, Liang, Guojin, additional, Yang, Shuo, additional, Huang, zhaodong, additional, Yang, Qi, additional, Hong, Hu, additional, Li, Xinliang, additional, Chen, Ze, additional, Fan, Jun, additional, and Zhi, Chunyi, additional

Published
2023
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173. Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway

Author

Huang, Huaying, primary, Jin, Ke, additional, Ouyang, Ke, additional, Jiang, Zhengyi, additional, Yang, Zhan, additional, Hu, Nannan, additional, Dai, Yan, additional, Zhang, Yaqin, additional, Zhang, Qian, additional, Han, Ying, additional, Zhao, Jie, additional, Lin, Hong, additional, Wang, Chunhui, additional, Wang, Chunyan, additional, Sun, Xuewei, additional, Lu, Dafeng, additional, Zhu, Jin, additional, and Li, Jun, additional

Published
2022
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175. The valuable role of dynamic 18F FDG PET/CT-derived kinetic parameter Ki in patients with nasopharyngeal carcinoma prior to radiotherapy: a prospective study

Author

Huang, Xiaotao, primary, Zhuang, Mingzan, additional, Yang, Shuai, additional, Wang, Ying, additional, Liu, Qiaodan, additional, Xu, Xiwei, additional, Xiao, Mei, additional, Peng, Yingpeng, additional, Jiang, Ping, additional, Xu, Wenhua, additional, Guo, Shuanshuan, additional, Wang, Rong, additional, Wei, Wei, additional, Zhong, Guihua, additional, Zhou, Yuling, additional, Peng, Shunli, additional, Li, Xuanzi, additional, Cui, Jianqi, additional, Wang, Siyang, additional, Zhang, Yaqin, additional, and Liu, Zhigang, additional

Published
2022
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176. Resveratrol enhances MUC2 synthesis via the ANRIL-miR-34a axis to mitigate IBD

Author

Zhou, Xiangjun, Zhang, Yaqin, Hu, Mengmou, Ge, Zhenghui, and Zhou, Guoxiong

Subjects
Original Article
Abstract

Background/aims: Resveratrol (RSV) is a natural polyphenol with strong biological activity that confers a measure of protection against the development of inflammatory bowel disease (IBD), and the long noncoding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) is closely related to inflammation. The present study determined whether resveratrol attenuated IBD by regulating ANRIL and its specific molecular mechanism. Methods: In vivo model of IBD was induced by dextran sulfate sodium (DSS). In total, 60 BALB/c mice were randomly divided into 3 groups (normal control - NC, DSS, RSV), and their weight changes, fecal traits, colon length and tissue hematoxylin-eosin (H&E) were observed. Moreover, human colonic epithelial cells (HCoEpiC) treated with lipopolysaccharide (LPS) were used as cell models of IBD. The tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, IL-10, lncRNA ANRIL, and miR-34a levels were measured by RT-PCR. The expression of mucin 2 (MUC2) and an enzyme associated with MUC2 synthesis, polypeptide N-acetylgalactosaminyltransferase 7 (GALNT7), was measured by RT-PCR and western blot analysis. Results: Resveratrol treatment mitigated colitis by significantly decreasing the expression of pro-inflammatory cytokines (i.e. TNF-α, IL-1β, IL-6) and miR-34a, and increasing the levels of anti-inflammatory cytokine (i.e. IL-10), MUC2, GLNAT7, and lncRNA ANRIL in mice and HCoEpiC (all P

Published
2023

178. Val109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis

Author

Chen, Ruofei, Zhang, Yaqin, Xu, Honggang, Hu, Huaqing, Chen, Mingwei, and Shuai, Zongwen

Subjects
Male, obesity, China, Genotype, Pharmaceutical Science, GPI-Linked Proteins, Polymorphism, Single Nucleotide, knee osteoarthritis, Body Mass Index, single nucleotide polymorphism, Lectins, Drug Discovery, Humans, Original Research, Aged, Pharmacology, Drug Design, Development and Therapy, Chinese, Incidence, Valine, Middle Aged, Osteoarthritis, Knee, omentin-1, Case-Control Studies, biomarker, Cytokines, Female, Biomarkers
Abstract

Ruofei Chen,1,&ast; Yaqin Zhang,1,&ast; Honggang Xu,2 Huaqing Hu,3 Mingwei Chen,4 Zongwen Shuai1 1Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui Province, People’s Republic of China; 2Department of Sports Injury and Arthroscopic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui Province, People’s Republic of China; 3Health Management Center, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui Province, People’s Republic of China; 4Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Mingwei Chen; Zongwen Shuai Email chmw1@163.com; amushuaizw@163.comObjective: To investigate the correlation of the Val109Asp polymorphism of the omentin-1 gene with the risk and severity of knee osteoarthritis (KOA) in a Chinese Han population.Methods: This study enrolled 383 patients with primary KOA and 460 healthy controls. The genotypes were determined by the detection of single nucleotide polymorphism. To explore the interaction between omentin-1 gene polymorphism and obesity and age, the body mass index (BMI) of 25 kg/m2 and the age of 55 years old were preset as the cut-off value of stratified analysis. Furthermore, enzyme-linked immunosorbent assay was used to determine the levels of omentin-1, interleukin (IL)-1β, IL-6 in peripheral blood and synovial fluid and the contents of IL-1β, IL-6, metalloproteinase (MMP)-13 and collagen (COL)-II in the supernatant of knee joint cartilage tissue.Results: The Val109Asp polymorphism of the omentin-1 gene showed no obvious correlation with KOA. Compared with Asp/Asp genotype carriers with BMI < 25 kg/m2 and age < 55 years old, Val109 allele carriers with BMI≥ 25 kg/m2 and age ≥ 55 years old had obviously increased risk of KOA (adjusted OR = 1.416, p = 0.042; adjusted OR = 1.735, p = 0.038, respectively). In the KOA group, only the omentin-1 levels were significantly lower in the plasma and synovial fluid of Ala/Ala genotype carriers than in those of Asp/Asp genotype carriers. Meanwhile, the proportion of patients with moderate–severe K-L Classification, the levels of IL-1β, IL-6 in synovial fluid and the expression levels of IL-1β, IL-6 and MMP-13 in cartilage tissue significantly increased (p < 0.05). By contrast, the expression level of COL-II in cartilage tissue significantly decreased (p < 0.05).Conclusions: The Val109Asp polymorphism of the omentin-1 gene may not be the primary pathogenic factor of KOA in Chinese. The Val/Val genotype can be regarded as a potential biomarker for the risk of KOA progression.Keywords: omentin-1, single nucleotide polymorphism, knee osteoarthritis, biomarker, Chinese, obesity

Published
2021

181. A High Fidelity Simulation Framework for Potential Safety Benefits Estimation of Cooperative Pedestrian Perception

Author

Chen, Longrui, Zhang, Yan, Jiang, Wenjie, Gong, Jiangtao, Shen, Jiahao, Chu, Mengdi, Li, Chuxuan, Pan, Yifeng, Shi, Yifeng, Luo, Nairui, Gao, Xu, Yuan, Jirui, Zhou, Guyue, and Zhang, Yaqin

Subjects
FOS: Computer and information sciences, Computer Science - Robotics, Artificial Intelligence (cs.AI), Computer Science - Artificial Intelligence, Computer Science - Human-Computer Interaction, Robotics (cs.RO), Human-Computer Interaction (cs.HC)
Abstract

This paper proposes a high-fidelity simulation framework that can estimate the potential safety benefits of vehicle-to-infrastructure (V2I) pedestrian safety strategies. This simulator can support cooperative perception algorithms in the loop by simulating the environmental conditions, traffic conditions, and pedestrian characteristics at the same time. Besides, the benefit estimation model applied in our framework can systematically quantify both the risk conflict (non-crash condition) and the severity of the pedestrian's injuries (crash condition). An experiment was conducted in this paper that built a digital twin of a crowded urban intersection in China. The result shows that our framework is efficient for safety benefit estimation of V2I pedestrian safety strategies., The content needs to be modified

Published
2022

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