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Titanium dioxide nanobelts were prepared via the alkali-hydrothermal method for application in chemical gas sensing. The formation process of TiO2-(B) nanobelts and their sensing properties were investigated in detail. FE-SEM was used to study the surface of the obtained structures. The TEM and XRD analyses show that the prepared TiO2 nanobelts are in the monoclinic phase. Furthermore, TEM shows the formation of porous-like morphology due to crystal defects in the TiO2-(B) nanobelts. The gas-sensing performance of the structure toward various concentrations of hydrogen, ethanol, acetone, nitrogen dioxide, and methane gases was studied at a temperature range between 100 and 500 °C. The fabricated sensor shows a high response toward acetone at a relatively low working temperature (150 °C), which is important for the development of low-power-consumption functional devices. Moreover, the obtained results indicate that monoclinic TiO2-B is a promising material for applications in chemo-resistive gas detectors.

This paper draws draw on conceptualisations of language as heteroglossic to examine whether and how multilingual practices and plurilingual pedagogies are enacted as instructional strategies in two multilingual English-medium universities in western Canada. Multilingual educational contexts have the potential to comprise 'translanguaging spaces' [Li, W. (2018). Translanguaging as a practical theory of language. "Applied Linguistics," 39(1), 9-30. doi:10.1093/applin/amx039], wherein educators and students mobilise a range of semiotic resources for teaching and learning purposes. From a monolingual paradigm, such practice is often seen as interference or deficit; however, from a multilingual paradigm, this practice is seen as legitimate and unrestricted, with students free to use their linguistic resources as they wish to their own benefit. To conceptualise and analyse engagement with multilingual practice, we draw on Cenoz and Gorter's [(2017). Minority languages and sustainable translanguaging: Threat or opportunity? "Journal of Multilingual and Multicultural Development," 38(10), 901-912. doi:10.1080/01434632.2017.1284855] distinction between 'spontaneous' and 'intentional' translanguaging. To assist faculty to observe, act and reflect on implementation of plurilingual pedagogies, we propose a three-dimensional matrix comprising axes of (1) faculty- and student-initiated; (2) planned and spontaneous engagements with plurilingualism; and (3) plurilingualism as either a scaffold or a resource for curriculum, pedagogy and assessment.

Measurement(s) ((18)O)water • deuterium(.) • waterflux • Relative Humidity • Air temperature • Snow depth Technology Type(s) wavelength scanned cavity ring-down spectrometer • off-axis integrated cavity output spectrometry • stream gauge, rain gauge • weather station Factor Type(s) catchment • location_ID • source • waterflux_measured • precipitation_interpolated • analysis_method • delta_2H • delta_18O • rel_humidity • air_temperature • snow_depth • notes_sampling • notes_other Sample Characteristic - Environment continental temperate Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.17013848

Stadium grandstands may experience high vibration levels due to the crowd action. Existing codes and guidelines used for the design and the assessment of grandstands highlight the need of an already ongoing revision, since there is a lack of information about the real nature of the crowd excitation and its accurate evaluation. This paper describes a highly improved computer vision method, based on the use of Digital Image Correlation (DIC), able to provide reliable estimates of the crowd induced loads on stadium grandstands. The effectiveness and the applicability of DIC is validated through a series of experimental tests held at the G. Meazza stadium in Milan. A first study with 27 jumping volunteers is carried out to assess the performance of DIC in a real environment. Then, the procedure is extended to the case of a larger crowd made of 108 individuals. In both cases, the forces estimated through image processing have been used in conjunction with the impulse response function of the stand to determine the resulting structural vibrations. The comparison between measured and computed vibrations provides a good agreement both in the time and the frequency domain.

We present the design and experimental characterization of a CMOS sensor based on Single-Photon Avalanche Diodes for direct Time-Of-Flight single-point distance ranging, under high background illumination for short-range applications. The sensing area has a rectangular shape ( $40\,\,\mathbf {\mathrm {\times }}\,\,10$ SPADs) to deal with the backscattered light spot displacement across the detector, dependent on target distance, due to the non-confocal optical setup. Since only few SPADs are illuminated by the laser spot, we implemented a smart laser-spot tracking within the active area, so to define the specific Region-Of-Interest (ROI) with only SPADs hit by signal photons and a smart sharing of the timing electronics, so to significantly improve Signal-to-Noise Ratio (SNR) of TOF measurements and to reduce overall chip area and power consumption. The timing electronics consists of 80 Time-to-Digital Converter (TDC) shared among the 400 SPADs with a self-reconfigurable routing, which dynamically connects the SPADs within the ROI to the available TDCs. The latter have 78 ps resolution and 20 ns Full-Scale Range (FSR), i.e., up to 2 m maximum distance range. An on-chip histogram builder block accumulates TDC conversions so to provide the final TOF histogram. We achieve a precision better than 2.3 mm at 1 m distance and 80% target reflectivity, with 3 klux halogen lamp background illumination and 2 kHz measurement rate. The sensor rejects 10 klux of background light, still with a precision better than 20 mm at 2 m.

Background: In Italy, regions have the mandate to implement population-based screening programs for breast, cervical, and colorectal cancer. From March to May 2020, a severe lockdown was imposed due to the COVID-19 pandemic by the Italian Ministry of Health, with the suspension of screening programs. This paper describes the impact of the pandemic on Italian screening activities and test coverage in 2020 overall and by socioeconomic characteristics. Methods: The regional number of subjects invited and of screening tests performed in 2020 were compared with those in 2019. Invitation and examination coverage were also calculated. PASSI surveillance system, through telephone interviews, collects information about screening test uptake by test provider (public screening and private opportunistic). Test coverage and test uptake in the last year were computed by educational attainment, perceived economic difficulties, and citizenship. Results: A reduction of subjects invited and tests performed, with differences between periods and geographical macro areas, was observed in 2020 vs. 2019. The reduction in examination coverage was larger than that in invitation coverage for all screening programs. From the second half of 2020, the trend for test coverage showed a decrease in all the macro areas for all the screening programs. Compared with the pre-pandemic period, there was a greater difference according to the level of education in the odds of having had a test last year vs. never having been screened or not being up to date with screening tests. Conclusions: The lockdown and the ongoing COVID-19 emergency caused an important delay in screening activities. This increased the preexisting individual and geographical inequalities in access. The opportunistic screening did not mitigate the impact of the pandemic. Funding: This study was partially supported by Italian Ministry of Health – Ricerca Corrente Annual Program 2023 and by the Emilian Region DGR 839/22.

This article brings together how three LPL researchers see the role of the body in teaching and/or learning a modern language, each one within a distinct but complementary theoretical framework – gesture studies, embodied cognition and cognitive science – and a specific area of interest: language didactics, education and psycholinguistics/neurolinguistics. In a three-voice exchange, we discuss our respective contexts and our research, highlighting our common points. We ask the following question: How do our different studies converge to show the fundamental role of the body in teaching and learning modern languages? 1. How do we define the body? In our research, we approach the body differently, according to our respective theoretical frameworks. For example, though focused mainly on the hands, facial expressions and head or eyebrow movements, gesture studies can also take into account posture, gaze and how space is occupied, as these are all aspects of pedagogical action (Azaoui, 2019; Tellier, 2008). In this context, it is important to observe body movements in relation to speech so as to understand how gesture is articulated with it in co-constructing meaning (McNeill, 1992; Azaoui and Tellier, 2020) and regulating interaction (Bavelas et al. 1995). In recent decades, and particularly since the unifying work of Aden (2004), the enactive-performative approach to language teaching (Eschenauer, 2019; Aden and Eschenauer, 2020) broke ground for Varela’s enaction paradigm (Varela et al., 1992) to be applied to artistic performance. Interdisciplinary work on embodied cognition is indeed paving the way for asserting that language links the body and the mind (Varela, 1989a). Researchers have observed that the mechanisms of resonance (automatic) and imitation (intentional) support language autonomy. These mechanisms are solicited by teachers and artists in a holistic approach to language that includes sensoriality, emotions (perceptive level), motor skills (mimo-gestures, body postures, movements in space, articulation), vocal variations, gaze and memorization. The awareness of this perception-action coupling as cognitive process through reflexive activities updates learning (Varela, 1988, 1989b; Trocmé-Fabre, 1987, 1999; Noë, 2006). Hence, learning always occurs in relation to oneself, to others and to the environment that generates a perception-action coupling. It would therefore seem important that the majority of the activities initiated by teachers not be static, including those involving adolescents or adult learners. Finally, cognitive science, takes into account the whole body and its interaction with the environment. The relationship between experience and conceptual representations is central here. In order to better understand it, studies have focused on the role of the body in language processing and learning. For example, in order to investigate how action and language processing influence one another, studies have observed the effects of hand/arm or leg/foot action preparation and execution on action language processing (Boulenger et al., 2006; Zappa et al., 2019). Importantly, in the context of embodied cognition, a strong link has been found between language processing and motor activation (Pulvermüller et al., 2005). 2. One’s own body and others’ bodies: the languaging body in interactions Studies have shown a link between empathy skills and the ability to switch between language registers (Aden, 2010; Eschenauer, 2014, 2018). Indeed, it would seem that the more a subject develops his or her ability to empathize, the more easily he or she navigates between his or her bodily and verbal repertoire, and vice versa (Eschenauer, 2017). Yet, the competence of empathy is complex: it is defined as the ability to put oneself in the place of another person while being aware of oneself (Decety, 2010; Thirioux et Berthoz, 2010). This self-other distinction is spatio-temporal, kinesthetic, sensory, emotional, and mental. For instance, observers recruit their own motor repertoire in order to understand others’ intentions (Rizzolatti & Sinigaglia, 2006; Gallagher, 2011). Awareness of this bodily strategy is very useful for language learners, especially when they still lack lexicon (Eschenauer, 2020). Emotional literacy (Chisholm & Strayer, 1995; Mayer & Salovey, 1997) and aesthetic experience (Vischer, 1873) are also components of empathy that provide access to meaning in interactions. These results are consistent with gesture studies on adaptation to the interlocutor. For example, in exolingual interactions (with non-native speakers), pre-service teachers produce more frequent, more illustrative, larger and longer gestures with non-natives than with native interlocutors, in order to facilitate discourse comprehension (Tellier, Stam, & Ghio, 2021). 3. Methodological issues We then situate our research within our various methodologies. When using an ecological approach, classroom video-recordings are used to describe and qualitatively analyze how pedagogical gestures operate, their articulation with speech and their functions (Azaoui, 2019; Pavlovskaya, 2021; Tellier, 2008a). Within a semi-controlled approach, speakers are given the same instructions and their productions are collected; some variables are controlled such as experimental conditions and whether participants are observed in the first, second or third person (Depraz, 2014). Thus, subjective data can be objectified (Eschenauer, 2017, 2020). In an experimental approach, variables are more controlled, as are the experimental conditions and stimuli. In psycholinguistics, and neurolinguistics in particular, measures such as reaction time, eye movements, or brain measures via functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), or electroencephalography (EEG), for instance, are used to better understand the relationship between the body and language processing. For example, motor activation in the brain can be measured via EEG as participants hear action verbs, prior to preparing an action on a virtual object, in a controlled virtual environment (Zappa et al., 2019). In this article, we defend a circular vision of these methodological approaches, as well as their complementarity. For instance, one can opt for a mixed protocol integrating qualitative measures along with quantitative psychometric tests such as the Interpersonal Reactivity Index (IRI) empathy test (Davis, 1980) to compare data on a single subject with a population of the same age (Eschenauer, 2018a). In order to gain more control, declarative measures can be triangulated with physiological measures (spontaneous EEG, Heart Rate (HR) and/or electrodermal activity (EDA)) as is the case of the current CELaViE study protocol. In conclusion, although anchored in different theoretical frameworks and relying on various scientific methodologies, our research brings complementary insights regarding a common subject: the essential function of the body in foreign language teaching/learning. This synthesis of our independent work is also an opportunity to create a research community that can open up new avenues of investigation based on hybrid methodologies (qualitative and quantitative), such as the CELaViE (Creativity and Empathy by Modern Language Learning at School: a performative approach to language education) project or the AFLEX project (which addresses the flexible arrangement of classrooms to give the body a place in learning, particularly of modern languages).

Ice shelves control sea-level rise through frictional resistance, which slows the seaward flow of grounded glacial ice. Evidence from around Antarctica indicates that ice shelves are thinning and weakening, primarily driven by warm ocean water entering into the shelf cavities. We have identified a mechanism for ice shelf destabilization where basal channels underneath the shelves cause ice thinning that drives fracture perpendicular to flow. These channels also result in ice surface deformation, which diverts supraglacial rivers into the transverse fractures. We report direct evidence that a major 2016 calving event at Nansen Ice Shelf in the Ross Sea was the result of fracture driven by such channelized thinning and demonstrate that similar basal channel-driven transverse fractures occur elsewhere in Greenland and Antarctica. In the event of increased basal and surface melt resulting from rising ocean and air temperatures, ice shelves will become increasingly vulnerable to these tandem effects of basal channel destabilization.

This study investigates the global response of the midlatitude atmospheric circulation to 1.5 and 2.0g°C of warming using the HAPPI (Half a degree Additional warming, Prognosis and Projected Impacts) ensemble, with a focus on the winter season. Characterising and understanding this response is critical for accurately assessing the near-term regional impacts of climate change and the benefits of limiting warming to 1.5g°C above pre-industrial levels, as advocated by the Paris Agreement of the United Nations Framework Convention on Climate Change (UNFCCC). The HAPPI experimental design allows an assessment of uncertainty in the circulation response due to model dependence and internal variability. Internal variability is found to dominate the multi-model mean response of the jet streams, storm tracks, and stationary waves across most of the midlatitudes; larger signals in these features are mostly consistent with those seen in more strongly forced warming scenarios. Signals that emerge in the 1.5g°C experiment are a weakening of storm activity over North America, an inland shift of the North American stationary ridge, an equatorward shift of the North Pacific jet exit, and an equatorward intensification of the South Pacific jet. Signals that emerge under an additional 0.5g°C of warming include a poleward shift of the North Atlantic jet exit, an eastward extension of the North Atlantic storm track, and an intensification on the flanks of the Southern Hemisphere storm track. Case studies explore the implications of these circulation responses for precipitation impacts in the Mediterranean, in western Europe, and on the North American west coast, paying particular attention to possible outcomes at the tails of the response distributions. For example, the projected weakening of the Mediterranean storm track emerges in the 2g°C warmer world, with exceptionally dry decades becoming 5 times more likely.

This study investigates the global response of the midlatitude atmospheric circulation to 1.5 and 2.0g°C of warming using the HAPPI (Half a degree Additional warming, Prognosis and Projected Impacts) ensemble, with a focus on the winter season. Characterising and understanding this response is critical for accurately assessing the near-term regional impacts of climate change and the benefits of limiting warming to 1.5g°C above pre-industrial levels, as advocated by the Paris Agreement of the United Nations Framework Convention on Climate Change (UNFCCC). The HAPPI experimental design allows an assessment of uncertainty in the circulation response due to model dependence and internal variability. Internal variability is found to dominate the multi-model mean response of the jet streams, storm tracks, and stationary waves across most of the midlatitudes; larger signals in these features are mostly consistent with those seen in more strongly forced warming scenarios. Signals that emerge in the 1.5g°C experiment are a weakening of storm activity over North America, an inland shift of the North American stationary ridge, an equatorward shift of the North Pacific jet exit, and an equatorward intensification of the South Pacific jet. Signals that emerge under an additional 0.5g°C of warming include a poleward shift of the North Atlantic jet exit, an eastward extension of the North Atlantic storm track, and an intensification on the flanks of the Southern Hemisphere storm track. Case studies explore the implications of these circulation responses for precipitation impacts in the Mediterranean, in western Europe, and on the North American west coast, paying particular attention to possible outcomes at the tails of the response distributions. For example, the projected weakening of the Mediterranean storm track emerges in the 2g°C warmer world, with exceptionally dry decades becoming 5 times more likely.

The inaugural data from the first systematic program of sea-ice observations in Kotzebue Sound, Alaska, in 2018 coincided with the first winter in living memory when the Sound was not choked with ice. The following winter of 2018–19 was even warmer and characterized by even less ice. Here we discuss the mass balance of landfast ice near Kotzebue (Qikiqtaġruk) during these two anomalously warm winters. We use in situ observations and a 1-D thermodynamic model to address three research questions developed in partnership with an Indigenous Advisory Council. In doing so, we improve our understanding of connections between landfast ice mass balance, marine mammals and subsistence hunting. Specifically, we show: (i) ice growth stopped unusually early due to strong vertical ocean heat flux, which also likely contributed to early start to bearded seal hunting; (ii) unusually thin ice contributed to widespread surface flooding. The associated snow ice formation partly offset the reduced ice growth, but the flooding likely had a negative impact on ringed seal habitat; (iii) sea ice near Kotzebue during the winters of 2017–18 and 2018–19 was likely the thinnest since at least 1945, driven by a combination of warm air temperatures and a persistent ocean heat flux.

This article presents the results of a death review study of 34 cases of femicide in the Federal District, Brazil, between 2016 and 2017. The aim of the study is to analyse how primary, secondary and tertiary prevention policies could have enhanced the prevention of these particular femicides. The study uses a mixed-method research design to analyse the judicial and health files of victims and perpetrators, supplemented by semi-structured interviews with surviving relatives. The findings highlight the need for an intersectional approach to gender, race, class and migration status in prevention policies; better risk assessment and management; enhanced women’s reporting of domestic violence earlier; and better integration of the justice system with psychosocial services. The increase of violence against women during the COVID-19 pandemic strengthens the need for an integrated approach to the prevention of lethal gender violence. This paper provides an original contribution to better comprehend the profile of femicide victims and perpetrators with a view on how to improve prevention policies in Brazil.

In their natural environment, most bacteria preferentially live as complex surface-attached multicellular colonies called biofilms. Biofilms begin with a few cells adhering to a surface, where they multiply to form a mature colony. When conditions deteriorate, cells can leave the biofilm. This dispersion is thought to be an important process that modifies the overall biofilm architecture and that promotes colonization of new environments. In Caulobacter crescentus biofilms, extracellular DNA (eDNA) is released upon cell death and prevents newborn cells from joining the established biofilm. Thus, eDNA promotes the dispersal of newborn cells and the subsequent colonization of new environments. These observations suggest that eDNA is a cue for sensing detrimental environmental conditions in the biofilm. Here, we show that the toxin–antitoxin system (TAS) ParDE4 stimulates cell death in areas of a biofilm with decreased O2 availability. In conditions where O2 availability is low, eDNA concentration is correlated with cell death. Cell dispersal away from biofilms is decreased when parDE4 is deleted, probably due to the lower local eDNA concentration. Expression of parDE4 is positively regulated by O2 and the expression of this operon is decreased in biofilms where O2 availability is low. Thus, a programmed cell death mechanism using an O2-regulated TAS stimulates dispersal away from areas of a biofilm with decreased O2 availability and favors colonization of a new, more hospitable environment.

As products of the waves of deregulation and liberalization of trade and investments in the region in the 1980s and mid-1990s, special economic zones (SEZs) have emerged as an important tool of economic governance in East and Southeast Asia. Recently, governments and investors around the region, have favored multi-purpose SEZs conceived for land and real estate development which exhibit several similarities such as eliciting tourism as the main driver of local development and a declared “eco” and “green” configuration. The Incheon Free Economic Zone (IFEZ) in the Republic of Korea (ROK) and the Van Don SEZ in the Socialist Republic of Vietnam (SRV) are two illustrative cases of urban policy diffusion as a complex phenomenon combining the ROK’s increased international activism and SRV’s own institutional structure and preferences in terms of development goals. Based on a close reading of reports, official documents, qualitative interviews and site visits, this article will further contribute to the debate on the complexity of urban policy diffusion in contemporary East and Southeast Asia.

In 2009, the International Soil Moisture Network (ISMN) was initiated as a community effort, funded by the European Space Agency, to serve as a centralised data hosting facility for globally available in situ soil moisture measurements (Dorigo et al., 2011b, a). The ISMN brings together in situ soil moisture measurements collected and freely shared by a multitude of organisations, harmonises them in terms of units and sampling rates, applies advanced quality control, and stores them in a database. Users can freely retrieve the data from this database through an online web portal (https://ismn.earth/en/, last access: 28 October 2021). Meanwhile, the ISMN has evolved into the primary in situ soil moisture reference database worldwide, as evidenced by more than 3000 active users and over 1000 scientific publications referencing the data sets provided by the network. As of July 2021, the ISMN now contains the data of 71 networks and 2842 stations located all over the globe, with a time period spanning from 1952 to the present. The number of networks and stations covered by the ISMN is still growing, and approximately 70 % of the data sets contained in the database continue to be updated on a regular or irregular basis. The main scope of this paper is to inform readers about the evolution of the ISMN over the past decade, including a description of network and data set updates and quality control procedures. A comprehensive review of the existing literature making use of ISMN data is also provided in order to identify current limitations in functionality and data usage and to shape priorities for the next decade of operations of this unique community-based data repository.

Abstract Background Despite being preventable, suicide is a leading cause of death and a major global public health problem. For every death by suicide, many more suicide attempts are undertaken, and this presents as a critical risk factor for suicide. Currently, there are limited treatment options with limited underpinning research for those who present to emergency departments with suicidal behaviour. The aim of this study is to assess if adding one of two structured suicide-specific psychological interventions (Attempted Suicide Short Intervention Program [ASSIP] or Brief Cognitive Behavioural Therapy [CBT] for Suicide Prevention) to a standardised clinical care approach (Suicide Prevention Pathway [SPP]) improves the outcomes for consumers presenting to a Mental Health Service with a suicide attempt. Methods This is a randomised controlled trial with blinding of those assessing the outcomes. People who attempt suicide or experience suicidality after a suicide attempt, present to the Gold Coast Mental Health and Specialist Services, are placed on the Suicide Prevention Pathway (SPP), and meet the eligibility criteria, are offered the opportunity to participate. A total of 411 participants will be recruited for the study, with 137 allocated to each cohort (participants are randomised to SPP, ASSIP + SPP, or CBT + SPP). The primary outcomes of this study are re-presentation to hospitals with suicide attempts. Presentations with suicidal ideation will also be examined (in a descriptive analysis) to ascertain whether a rise in suicidal ideation is commensurate with a fall in suicide attempts (which might indicate an increase in help-seeking behaviours). Death by suicide rates will also be examined to ensure that representations with a suicide attempt are not due to participants dying, but due to a potential improvement in mental health. For participants without a subsequent suicide attempt, the total number of days from enrolment to the last assessment (24 months) will be calculated. Self-reported levels of suicidality, depression, anxiety, stress, resilience, problem-solving skills, and self- and therapist-reported level of therapeutic engagement are also being examined. Psychometric data are collected at baseline, end of interventions, and 6,12, and 24 months. Discussion This project will move both ASSIP and Brief CBT from efficacy to effectiveness research, with clear aims of assessing the addition of two structured psychological interventions to treatment as usual, providing a cost-benefit analysis of the interventions, thus delivering outcomes providing a clear pathway for rapid translation of successful interventions. Trials registration ClinicalTrials.gov NCT04072666 . Registered on 28 August 2019

Abstract Pompe disease is a metabolic myopathy due to acid alpha‐glucosidase deficiency. In addition to glycogen storage, secondary dysregulation of cellular functions, such as autophagy and oxidative stress, contributes to the disease pathophysiology. We have tested whether oxidative stress impacts on enzyme replacement therapy with recombinant human alpha‐glucosidase (rhGAA), currently the standard of care for Pompe disease patients, and whether correction of oxidative stress may be beneficial for rhGAA therapy. We found elevated oxidative stress levels in tissues from the Pompe disease murine model and in patients’ cells. In cells, stress levels inversely correlated with the ability of rhGAA to correct the enzymatic deficiency. Antioxidants (N‐acetylcysteine, idebenone, resveratrol, edaravone) improved alpha‐glucosidase activity in rhGAA‐treated cells, enhanced enzyme processing, and improved mannose‐6‐phosphate receptor localization. When co‐administered with rhGAA, antioxidants improved alpha‐glucosidase activity in tissues from the Pompe disease mouse model. These results indicate that oxidative stress impacts on the efficacy of enzyme replacement therapy in Pompe disease and that manipulation of secondary abnormalities may represent a strategy to improve the efficacy of therapies for this disorder.

While ensuring food security worldwide, irrigation is altering the water cycle and generating numerous environmental side effects. As detailed knowledge about the timing and the amounts of water used for irrigation over large areas is still lacking, remotely sensed soil moisture has proved potential to fill this gap. However, the spatial resolution and revisit time of current satellite products represent a major limitation to accurately estimating irrigation. This work aims to systematically quantify their impact on the retrieved irrigation information, hence assessing the value of satellite soil moisture for estimating irrigation timing and water amounts.In a real-world experiment, we modeled soil moisture using actual irrigation and meteorological data, obtained from farmers and weather stations, respectively. Modeled soil moisture was compared against various remotely sensed products differing in terms of spatio-temporal resolution to test the hypothesis that high-resolution observations can disclose the irrigation signal from individual fields while coarse-scale satellite products cannot. Then, in a synthetic experiment, we systematically investigated the effect of soil moisture spatial and temporal resolution on the accuracy of irrigation estimates. The analysis was further elaborated by considering different irrigation scenarios and by adding realistic amounts of random errors in the soil moisture time series.We show that coarse-scale remotely sensed soil moisture products achieve higher correlations with rainfed simulations, while high-resolution satellite observations agree significantly better with irrigated simulations, suggesting that high-resolution satellite soil moisture can inform on field-scale (∼40 ha) irrigation. A thorough analysis of the synthetic dataset showed that satisfactory results, both in terms of detection (F-score > 0.8) and quantification (Pearson’s correlation > 0.8), are found for noise-free soil moisture observations either with a temporal sampling up to 3 days or if at least one-third of the pixel covers the irrigated field(s). However, irrigation water amounts are systematically underestimated for temporal samplings of more than one day, and decrease proportionally to the spatial resolution, i.e., coarsening the pixel size leads to larger irrigation underestimations. Although lower spatial and temporal resolutions decrease the detection and quantification accuracies (e.g., R between 0.6 and 1 depending on the irrigation rate and spatio-temporal resolution), random errors in the soil moisture time series have a stronger negative impact (Pearson R always smaller than 0.85). As expected, better performances are found for higher irrigation rates, i.e. when more water is supplied during an irrigation event. Despite the potentially large underestimations, our results suggest that high-resolution satellite soil moisture has the potential to track and quantify irrigation, especially over regions where large volumes of irrigation water are applied to the fields, and given that low errors affect the soil moisture observations.

The spectrum of TKI-related adverse events (AEs) is variable. Pleural effusion (PE) is a frequent AE attributable to dasatinib treatment, while it is only rarely associated with nilotinib. The pathogenetic mechanism leading to PE during nilotinib therapy is still unknown and its management has not yet been defined. To the best of our knowledge, only a limited number of similar case reports have already been reported in the literature so far. Here, we describe the case of a 41-year-old CML patient who developed PE during first-line nilotinib, successfully treated with steroids and nilotinib permanent discontinuation. We highlight the differences among our patient and the others, proposing therapeutic strategies to solve this rare but still possible AE, of which physicians should be aware.

Emphysematous hepatitis is a rare infectious disease, which corresponds to the presence of gas in the liver, without collection and after exclusion of vascular origin. This entity belongs to the group of emphysematous infections, whose physiopathology seems to be linked to the presence of unbalanced diabetes and to bacterial fermentation, leading to the production of gas within the liver parenchyma. Very few cases of emphysematous hepatitis have been described in the literature, and most of them had a rapidly fatal course. In this manuscript, we report the case of a 59-year-old man with emphysematous hepatitis due to wild-type Klebsiella pneumoniae that was successfully managed by surgery, and we perform a review of the literature to describe the clinical and biopathological aspects of this rare hepatic disease. Our manuscript underlines the need to perform biological and histopathological sampling to better understand the pathophysiology of this rare entity. The causes and mechanisms of emphysematous hepatitis, which seem to be multiple, lead us to believe that it is a syndrome rather than a simple infectious disease.

Unlike the conventional one-dimensional (1D) core–shell nanowires (NWs) composed of p-type shells and n-type cores, in this work, an inverse design is proposed by depositing n-type ZnO (shell) layers on the surface of p-type CuO (core) NWs, to have a comprehensive understanding of their conductometric gas-sensing kinetics. The surface morphologies of bare and core–shell NWs were investigated by field emission scanning electron microscope (FE-SEM). The ZnO shell layer was presented by overlay images taken by electron dispersive X-ray spectroscopy (EDX) and high-resolution transmission electron microscopy (HRTEM). The pronounced crystalline plane peaks of ZnO were recorded in the compared glancing incident X-ray diffraction (GI-XRD) spectra of CuO and CuO–ZnO core–shell NWs. The ZnO shell layers broaden the absorption curve of CuO NWs in the UV-vis absorption spectra. As a result of the heterostructure formation, the intrinsic p-type sensing behavior of CuO NWs towards 250 and 500 ppm of hydrogen (H2) switched to n-type due to the deposition of ZnO shell layers, at 400 °C in dry airflow.

The ITALUNG trial started in 2004 and compared lung cancer (LC) and other-causes mortality in 55–69 years-aged smokers and ex-smokers who were randomized to four annual chest low-dose CT (LDCT) or usual care. ITALUNG showed a lower LC and cardiovascular mortality in the screened subjects after 13 years of follow-up, especially in women, and produced many ancillary studies. They included recruitment results of a population-based mimicking approach, development of software for computer-aided diagnosis (CAD) and lung nodules volumetry, LDCT assessment of pulmonary emphysema and coronary artery calcifications (CAC) and their relevance to long-term mortality, results of a smoking-cessation intervention, assessment of the radiations dose associated with screening LDCT, and the results of biomarkers assays. Moreover, ITALUNG data indicated that screen-detected LCs are mostly already present at baseline LDCT, can present as lung cancer associated with cystic airspaces, and can be multiple. However, several issues of LC screening are still unaddressed. They include the annual vs. biennial pace of LDCT, choice between opportunistic or population-based recruitment. and between uni or multi-centre screening, implementation of CAD-assisted reading, containment of false positive and negative LDCT results, incorporation of emphysema. and CAC quantification in models of personalized LC and mortality risk, validation of ultra-LDCT acquisitions, optimization of the smoking-cessation intervention. and prospective validation of the biomarkers.

This paper presents palynological data obtained from a trench excavated at the Neolithic pile-dwelling archaeological site of Palù di Livenza (northeastern Italy). The site is in a wetland located in a tectonic basin at the foot of the Cansiglio plateau, crossed by the Livenza river. Environmental conditions have made this wetland a suitable area for settlements since prehistoric times. Thanks to the peaty sediments that characterise the area, archaeological materials and botanical remains have been exceptionally well preserved. Their study has shed light on a Neolithic pile-dwelling settlement that developed in various phases between c. 6350 and 5600 cal BP (c. 4400 and 3650 BC), and has also allowed for a detailed environmental reconstruction of the surrounding environment. A vertical sequence of 20 samples was analysed to study pollen, non-pollen palynomorphs and microcharcoals. An age-depth model was performed based on three radiocarbon dates. The palynological analysis provided insight into the response of vegetation to environmental changes caused by both climatic fluctuations and human pressure. In this sense, it was possible to highlight differences in vegetation cover, some fires, the use of woody resources, the spread of cereal fields, as well as the presence of other cultivated plants and plant processing by the people within the village.

Abstract Background Communication is pivotal to the effective care and treatment of patients in our health care systems. Despite this understanding, clinicians are not sufficiently educated to confidently conduct complex discussions with patients. Communication skills workshops have been shown to be an effective educational format to improve clinician skills. However, despite the increasing interprofessional focus within modern medicine, there have been few studies looking at interprofessional communication workshops. Methods A qualitative study was conducted to assess how an interprofessional communication skills workshop affected the communication skills of clinicians at a tertiary health service. Pre- and post-workshop surveys were undertaken by participants, followed by focus group interviews eight-weeks post workshop. Results Clinicians were able to incorporate learnt communication skills into their daily practice. This was associated with an improvement in confidence of clinicians in having complex discussions, in addition to a reduction in the burden of having complex discussions. Participants responded positively to the interdisciplinary format, reporting benefits from the learning experience that translated into daily practice. Conclusion Clinicians’ communication skills in conducting complex clinician-patient conversations can be improved by participation in interprofessional communication skills workshops. We identified that the interprofessional aspect of the workshops not only improved interprofessional understanding and relationships, but also developed increased self-awareness during complex discussions, and reduced the sense of burden felt by clinicians.

The past decade has seen significant technological advance in the observation of trace gas fluxes over the open ocean, most notably CO2, but also an impressive list of other gases. Here we will emphasize flux observations from the air-side of the interface including both turbulent covariance (direct) and surface-layer similarity-based (indirect) bulk transfer velocity methods. Most applications of direct covariance observations have been from ships but recently work has intensified on buoy-based implementation. The principal use of direct methods is to quantify empirical coefficients in bulk estimates of the gas transfer velocity. Advances in direct measurements and some recent field programs that capture a considerable range of conditions with wind speeds exceeding 20 ms-1 are discussed. We use coincident direct flux measurements of CO2 and dimethylsulfide (DMS) to infer the scaling of interfacial viscous and bubble-mediated (whitecap driven) gas transfer mechanisms. This analysis suggests modest chemical enhancement of CO2 flux at low wind speed. We include some updates to the theoretical structure of bulk parameterizations (including chemical enhancement) as framed in the COAREG gas transfer algorithm.

In addition to long-term regulation of blood pressure (BP), in the kidney resides the initial trigger for hypertension development due to an altered capacity to excrete sodium and water. Betaine is one of the major organic osmolytes, and its betaine/gamma-aminobutyric acid transporter (BGT-1) expression in the renal medulla relates to interstitial tonicity and urinary osmolality and volume. This study investigated altered water and sodium balance as well as changes in antidiuretic hormone (ADH) activity in female spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats from their 3–5 weeks of age (prehypertensive phase) to SHR’s 28–30 weeks of age (established hypertension-organ damage). Young prehypertensive SHRs showed a reduced daily urine output, an elevated urine osmolarity, and higher immunostaining of tubule BGT-1, alpha-1-Na-K ATPase in the outer medulla vs. age-matched WKY. ADH circulating levels were not different between young prehypertensive SHR and WKY, but the urine aquaporin2 (AQP2)/creatinine ratio and labeling of AQP2 in the collecting duct were increased. At 28–30 weeks, hypertensive SHR with moderate renal failure did not show any difference in urinary osmolarity, urine AQP2/creatinine ratio, tubule BGT-1, and alpha-1-Na-K ATPase as compared with WKY. These results suggest an increased sensitivity to ADH in prehypertensive female SHR. On this basis, a second series of experiments were set to study the role of ADH V1 and V2 receptors in the development of hypertension, and a group of female prehypertensive SHRs were treated from the 25th to 49th day of age with either V1 (OPC21268) or V2 (OPC 41061) receptor antagonists to evaluate the BP time course. OPC 41061-treated SHRs had a delayed development of hypertension for 5 weeks without effect in OPC 21268-treated SHRs. In prehypertensive female SHR, an increased renal ADH sensitivity is crucial for the development of hypertension by favoring a positive water balance. Early treatment with selective V2 antagonism delays future hypertension development in young SHRs.

Research on first language, second language, and multilingual socialization has flourished over the past three decades in many formal and informal educational contexts around the world. One relatively recent site for such research, particularly for multilingual students learning English as an additional language, is post-secondary institutions where English is the medium of instruction. This article reviews research on this topic conducted at Canadian universities in particular, focusing both on students enrolled in short (one year or less) study-abroad programs and on those in full degree programs (undergraduate and graduate) whose goals may include improving their English language proficiency and their disciplinary knowledge in various fields. It highlights the changing theoretical understandings of language/literacy socialization processes based on a number of studies, in terms of students' trajectories, the interplay of students' (multiple) languages in their learning and performance, the various agents and directions of their socialization, acts of resistance versus compliance with established norms, and the role of peer support and social networks in their academic and social experiences, and ways of tracking these. In addition, the article notes the various methodological approaches that exist for studying issues related to language/literacy socialization and the units of analysis typically involved in this research.

Within the insurance field, the digital revolution has enabled the collection and storage of large quantities of information [...]

Several outcome-based prospective investigations have provided solid data which support the prognostic value of 24 h ambulatory blood pressure over and beyond cardiovascular traditional risk factors. Average 24 h, daytime, and nighttime blood pressures are the principal components of the ambulatory blood pressure profile that have improved cardiovascular risk stratification beyond traditional risk factors. Furthermore, several additional ambulatory blood pressure measures have been investigated. The correct interpretation in clinical practice of ambulatory blood pressure monitoring needs a standardization of methods. Several algorithms for its clinical use have been proposed. Implementation of the results of ambulatory blood pressure monitoring in the management of individual subjects with the aim of improving risk stratification is challenging. We suggest that clinicians should focus attention on ambulatory blood pressure components which have been proven to act as the main independent predictors of outcome (average 24 h, daytime, and nighttime blood pressure, pulse pressure, dipping status, BP variability).

The pursuit of low-cost, high-efficiency co-catalysts that are free of noble metals has become an area of considerable interest in the field of photocatalysis over the past few years. In this work, a series of cobalt phosphide (CoP 0.125–1.00 wt.%)-promoted bismuth vanadate (BiVO4) photocatalysts was synthesized and physicochemical characterized by means of X-Ray diffraction, nitrogen isotherm absorption diffuse-reflectance spectroscopy, and high-resolution transmission electron microscopy. The efficiency of the as prepared photocatalytic materials was investigated for sulfamethoxazole (SMX) destruction in ultrapure water under simulated solar light irradiation. Results showed that the deposition of small amounts (0.50 wt.%) of CoP on BiVO4 enhances SMX degradation. Moreover, SMX removal increased by increasing 0.50 CoP/BiVO4 loading (up to 1 g/L) and decreasing SMX loading (1000–250 μg/L). Further tests were carried out in real and synthetic matrices, such as wastewater secondary effluent and bottled water, revealing the existence of hindering effects on SMX removal. The efficiency of 0.50 CoP/BiVO4 photocatalyst was further investigated in a pilot plant configuration where the examined system was able to remove >99% of 300 μg/L SMX in deionized water utilizing 80 kJ/L of solar irradiation.

The difficulty of calculating the daily water budget of irrigated fields is often due to the uncertainty surrounding irrigation amounts and timing. The automated detection of irrigation events has the potential to greatly simplify this process, and the combination of high-resolution SAR (Sentinel-1) and optical satellite observations (Sentinel-2) makes the detection of irrigation events feasible through the use of a surface soil moisture (SSM) product. The motivation behind this study is to utilize a large irrigation dataset (collected during the ESA Irrigation + project over five sites in three countries over three years) to analyze the performance of an established algorithm and to test potential improvements. The study’s main findings are (1) the scores decrease with SSM observation frequency; (2) scores decrease as irrigation frequency increases, which was supported by better scores in France (more sprinkler irrigation) than in Germany (more localized irrigation); (3) replacing the original SSM model with the force-restore model resulted in an improvement of about 6% in the F-score and narrowed the error on cumulative seasonal irrigation; (4) the Sentinel-1 configuration (incidence angle, trajectory) did not show a significant impact on the retrieval of irrigation, which supposes that the SSM is not affected by these changes. Other aspects did not allow a definitive conclusion on the irrigation retrieval algorithm: (1) the lower scores obtained with small NDVI compared to large NDVI were counter-intuitive but may have been due to the larger number of irrigation events during high vegetation periods; (2) merging different runs and interpolating all SSM data for one run produced comparable F-scores, but the estimated cumulative sum of irrigation was around −20% lower compared to the reference dataset in the best cases.

Abstract Background Spinal muscular atrophy (SMA) is a chronic, neuromuscular disease characterized by degeneration of spinal cord motor neurons, resulting in progressive muscular atrophy and weakness. SMA1 is the most severe form characterized by significant bulbar, respiratory, and motor dysfunction. SMA1 prevents children from speaking a clearly understandable and fluent language, with their communication being mainly characterized by eye movements, guttural sounds, and anarthria (type 1a); severe dysarthria (type 1b); and nasal voice and dyslalia (type 1c). The aim of this study was to analyze for the first time cognitive functions, language comprehension, and speech in natural history SMA1 children according to age and subtypes, to develop cognitive and language benchmarks that provide outcomes for the clinical medication trials that are changing SMA1 course/trajectory. Methods This is a retrospective study including 22 children with SMA1 (10 affected by subtype 1a-1b: AB and 12 by 1c: C) aged 3–11 years in clinical stable condition with a coded way to communicate “yes” and “no”. Data from the following assessments have been retrieved from patient charts: one-dimensional Raven test (RCPM), to evaluate cognitive development (IQ); ALS Severity Score (ALSSS) to evaluate speech disturbances; Brown Bellugy modified for Italian standards (TCGB) to evaluate language comprehension; and Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) to assess motor functioning. Results SMA 1AB and 1C children were similar in age, with the former characterized by lower CHOP-INTEND scores compared to the latter. All 22 children had collaborated to RCPM and their median IQ was 120 with no difference (p = 0.945) between AB and C. Global median score of the speech domain of the ALSSS was 5; however, it was 2 in AB children, being significantly lower than C (6.5, p < 0.001). TCGB test had been completed by 13 children, with morphosyntactic comprehension being in the normal range (50). Although ALSSS did not correlate with both IQ and TCGB, it had a strong (p < 0.001) correlation with CHOP-INTEND described by an exponential rise to maximum. Conclusions Although speech and motor function were severely compromised, children with SMA1 showed general intelligence and language comprehension in the normal range. Speech impairment was strictly related to global motor impairment.

Resumo Apresentamos o relato de caso de uma paciente com mixoma valvar mitral infectado e uma revisão da literatura sobre o assunto. Uma mulher de 33 anos apresentou histórico de febre e dispneia com evolução de alguns dias. Na hospitalização, ela apresentava uma síndrome semelhante ao lúpus, com hemoculturas positivas para Haemophilus spp . O ecocardiograma revelou uma massa gigante envolvendo ambos os folhetos mitrais associada à regurgitação grave, necessitando de troca valvar mitral biológica. A microscopia revelou mixoma infectado e a paciente recebeu alta assintomática após o término da antibioticoterapia. Ela apresentou bons resultados no seguimento. Este é o sexto caso de mixoma valvar mitral infectado relatado na literatura e o terceiro caso de mixoma cardíaco infectado pelo grupo HACEK. Devido à alta incidência de eventos embólicos, a antibioticoterapia precoce aliada à pronta intervenção cirúrgica são decisivos para a redução da morbimortalidade. O tempo para o diagnóstico foi muito mais breve do que o geralmente relatado em casos de endocardite por HACEK. A troca valvar foi a intervenção mais comum e todos os pacientes em relatos de caso anteriores apresentaram bons resultados no seguimento.

Patients suffering from chronic obstructive pulmonary disease (COPD) clinically manifest airway mucus hypersecretion as sputum expectoration and cough. Evidence accumulated in the past decade has shown that the cholinergic system not only regulates airway smooth muscle contraction but also the activity of inflammatory and airway epithelial cells, including goblet cells, and submucosal gland activity. Long-acting muscarinic antagonists (LAMAs) with the most favourable M3/M2 muscarinic acetylcholine (ACh) receptors residency properties are not only excellent bronchodilators but potentially also mucus-modifying agents, able to positively impact on mucus hypersecretion and cough. The aim of this systematic review was to investigate the impact of LAMAs on mucus hypersecretion and cough in COPD patients. The evidence confirmed that LAMAs, mainly tiotropium and aclidinium, improved sputum production and cough in moderate to severe COPD. Thus, LAMAs not only antagonise the ACh-induced bronchoconstriction of the airways but also appear to limit the production of mucus secreted in response to ACh by airway goblet cells and/or submucosal glands. Further clinical studies are necessary to evaluate the impact of LAMAs exclusively on sputum symptoms and cough as primary end-points and to investigate whether LAMAs have a modulatory action on the rheological properties of mucus.

Our Surface-Time-Of-Flight (SurfTOF) tandem mass spectrometer apparatus has been employed in a comparative investigation of ion sputtering induced by mono-energetic D+ and He+ ion beams impinging on a Be surface at 700 K with impact energies from 5 to 500 eV. Both chemically assisted sputtering (by D+ impact below 50 eV) and physical sputtering (by He+ and D+ above 50 eV) were observed. Be+ was the dominant sputtered ion at all energies. Chemically assisted sputtering mechanisms are proposed for the concomitant chemical sputtering of Be+, Be2+ and BeD+ ions (by D+ at low energies). Evidence was also obtained for the sputtering of BeO+ and Be2O+ by both He+ and D+ impact ions (with a minimum at 30 eV with D+), but only above 30 eV with He+. They are ascribed to the presence of BeO and Be2O impurities in the surface layer of Be. Water molecules adsorbed on the Be sample gave rise to BeH+ and BeOH+ in the sputtered ion spectrum primarily at higher energies above 30 eV where Be+ ejection is enhanced. Combined observations with a quartz crystal microbalance and a Faraday cup provided preliminary insight into the sputter yields of neutral and ionized beryllium. These results can be carried over to the erosion of Be by plasma deuterons, and T+ by extension, in its use as the first wall for the ITER blanket in fusion technology.