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156. Multicentre study found no increased risk of clinically important brain injuries when children presented more than 24 h after a minor head trauma.

Author

Vajna de Pava, Marco, Milani, Gregorio Paolo, Zuccotti, Gian Vincenzo, Tommasi, Paola, Calvi, Matteo, Amoroso, Angela, Montesano, Paola, Boselli, Giulia, Castellazzi, Massimo Luca, and Agosti, Massimo

Subjects
BRAIN injuries, PEDIATRIC emergencies, HOSPITAL emergency services
Abstract

Aim: Validated clinical decision rules on neuroimaging are not available for children who are evaluated more than 24 h after a minor head trauma. We compared clinically important traumatic brain injuries in children who presented with a minor head trauma within or after 24 h. Methods: This was a retrospective analysis of patients aged 0–17 years, who were evaluated for minor head traumas by five paediatric emergency departments in Northern Italy between January 2019 and June 2020. Children with clinically important traumatic brain injuries were divided into those who had presented within and after 24 h. Results: The study comprised 5981 children (59.9% boys), with a median age of 2 years, including 243 (4.1%) who had presented more than 24 h after their minor head trauma. Neuroimaging was performed on 448 (7.5%) patients and the time of presentation had no impact on the rates of clinically important traumatic brain injuries. Multiple logistic regression did not show any association between clinically important traumatic brain injuries and late presentation. Conclusion: Delayed presentation to a paediatric emergency department after a minor head trauma did not alter the risk of clinically important traumatic brain injuries and the same neuroimaging rules could apply. [ABSTRACT FROM AUTHOR]

Published
2022
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163. A Journey on the Skin Microbiome: Pitfalls and Opportunities

Author

Pistone, Dario, primary, Meroni, Gabriele, additional, Panelli, Simona, additional, D’Auria, Enza, additional, Acunzo, Miriam, additional, Pasala, Ajay Ratan, additional, Zuccotti, Gian Vincenzo, additional, Bandi, Claudio, additional, and Drago, Lorenzo, additional

Published
2021
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166. Structured Light Plethysmography (SLP) in COVID-19 children: a focus on Multisystem Inflammatory Syndrome in Children (MIS-C)

Author

Longoni, Emma, primary, Pascuzzi, Martina, additional, Riccaboni, Francesca, additional, Sartorio, Marco Ugo, additional, Ghezzi, Michele, additional, Farolfi, Andrea, additional, Piazza, Michele, additional, Tenero, Laura, additional, Piacentini, Giorgio, additional, D’Auria, Enza, additional, and Zuccotti, Gian Vincenzo, additional

Published
2021
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167. Does school reopening affect SARS-CoV-2 seroprevalence among school-age children in Milan?

Author

Barcellini, Lucia, primary, Forlanini, Federica, additional, Sangiorgio, Arianna, additional, Gambacorta, Greta, additional, Alberti, Luisella, additional, Meta, Andrea, additional, Gaia, Paola, additional, Amendola, Antonella, additional, Tanzi, Elisabetta, additional, Massa, Valentina, additional, Borghi, Elisa, additional, Fabiano, Valentina, additional, and Zuccotti, Gian Vincenzo, additional

Published
2021
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168. Anti-diabetic drugs and weight loss in patients with type 2 diabetes

Author

Lazzaroni, Elisa, primary, Ben Nasr, Moufida, additional, Loretelli, Cristian, additional, Pastore, Ida, additional, Plebani, Laura, additional, Lunati, Maria Elena, additional, Vallone, Luciana, additional, Bolla, Andrea Mario, additional, Rossi, Antonio, additional, Montefusco, Laura, additional, Ippolito, Elio, additional, Berra, Cesare, additional, D’Addio, Francesca, additional, Zuccotti, Gian Vincenzo, additional, and Fiorina, Paolo, additional

Published
2021
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170. Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growth

Author

Messa, Letizia, primary, Barzaghini, Bianca, additional, Rey, Federica, additional, Pandini, Cecilia, additional, Zuccotti, Gian Vincenzo, additional, Cereda, Cristina, additional, Carelli, Stephana Carelli, additional, and Raimondi, Manuela Teresa, additional

Published
2021
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171. Neonatal Diabetes in Patients Affected by Liang-Wang Syndrome Carrying KCNMA1 Variant p.(Gly375Arg) Suggest a Potential Role of Ca2+ and Voltage-Activated K+ Channel Activity in Human Insulin Secretion

Author

Mameli, Chiara, primary, Cazzola, Roberta, additional, Spaccini, Luigina, additional, Calcaterra, Valeria, additional, Macedoni, Maddalena, additional, La Verde, Paola Azzurra, additional, D’Auria, Enza, additional, Verduci, Elvira, additional, Lista, Gianluca, additional, and Zuccotti, Gian Vincenzo, additional

Published
2021
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173. Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 Infection

Author

Valeri, Andrea, primary, Chiricosta, Luigi, additional, Calcaterra, Valeria, additional, Biasin, Mara, additional, Cappelletti, Gioia, additional, Carelli, Stephana, additional, Zuccotti, Gian Vincenzo, additional, Bramanti, Placido, additional, Pelizzo, Gloria, additional, Mazzon, Emanuela, additional, and Gugliandolo, Agnese, additional

Published
2021
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178. Nutritional, Gastrointestinal and Endo-Metabolic Challenges in the Management of Children with Spinal Muscular Atrophy Type 1

Author

Corsello, Antonio, primary, Scatigno, Lorenzo, additional, Pascuzzi, Martina Chiara, additional, Calcaterra, Valeria, additional, Dilillo, Dario, additional, Vizzuso, Sara, additional, Pelizzo, Gloria, additional, Zoia, Elena, additional, Mandelli, Anna, additional, Govoni, Annalisa, additional, Bosetti, Alessandra, additional, Francavilla, Ruggiero, additional, Indrio, Flavia, additional, Fabiano, Valentina, additional, Zuccotti, Gian Vincenzo, additional, and Verduci, Elvira, additional

Published
2021
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180. Hematopoietic Stem Cells in Type 1 Diabetes

Author

Pastore, Ida, primary, Assi, Emma, additional, Ben Nasr, Moufida, additional, Bolla, Andrea Mario, additional, Maestroni, Anna, additional, Usuelli, Vera, additional, Loretelli, Cristian, additional, Seelam, Andy Joe, additional, Abdelsalam, Ahmed, additional, Zuccotti, Gian Vincenzo, additional, D’Addio, Francesca, additional, and Fiorina, Paolo, additional

Published
2021
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181. Epidemic preparedness - Leishmania tarentolae as an easy-to-handle tool to produce antigens for viral diagnosis: application to COVID-19

Author

Varotto-Boccazzi, Ilaria, primary, Manenti, Alessandro, additional, Dapporto, Francesca, additional, Gourlay, Louise J., additional, Bisaglia, Beatrice, additional, Gabrieli, Paolo, additional, Forneris, Federico, additional, Faravelli, Silvia, additional, Bollati, Valentina, additional, Zuccotti, Gian Vincenzo, additional, Montomoli, Emanuele, additional, Epis, Sara, additional, and Bandi, Claudio, additional

Published
2021
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182. Hypervariable-Locus Melting Typing (HLMT): a novel, fast and inexpensive sequencing-free approach to pathogen typing based on High Resolution Melting (HRM) analysis

Author

Perini, Matteo, primary, Piazza, Aurora, additional, Panelli, Simona, additional, Papaleo, Stella, additional, Alvaro, Alessandro, additional, Vailati, Francesca, additional, Corbella, Marta, additional, Saluzzo, Francesca, additional, Gona, Floriana, additional, Castelli, Daniele, additional, Farina, Claudio, additional, Marone, Piero, additional, Cirillo, Daniela Maria, additional, Cavallero, Annalisa, additional, Zuccotti, Gian Vincenzo, additional, and Comandatore, Francesco, additional

Published
2021
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183. Early-Transmitted Variants and Their Evolution in a HIV-1 Positive Couple: NGS and Phylogenetic Analyses

Author

Lai, Alessia, Giacomet, Vania, Bergna, Annalisa, Zuccotti, Gian Vincenzo, Zehender, Gianguglielmo, Clerici, Mario, Trabattoni, Daria, and Fenizia, Claudio

Subjects
Male, Adolescent, lcsh:QR1-502, Genetic Variation, HIV T/F variants, HIV Infections, HIV quasispecies, mucosal bottleneck, HIV deep phylogenetic NGS analyses, lcsh:Microbiology, Article, Quasispecies, human immunodeficiency virus (HIV), HIV sexual transmission, HIV evolution, HIV-1, Humans, RNA, Viral, Female, Phylogeny
Abstract

We had access to both components of a couple who became infected with human immunodeficiency virus (HIV)-1 through sexual behavior during the early initial phase of infection and before initiation of therapy. We analyzed blood samples obtained at the time of diagnosis and after six months of combined antiretroviral therapy. Next-generation sequencing (NGS) and phylogenetic analyses were used to investigate the transmission and evolution of HIV-1 quasispecies. Phylogenetic analyses were conducted using Bayesian inference methods. Both partners were infected with an HIV-1 B subtype. No evidence of viral recombination was observed. The lowest intrapersonal genetic distances were observed at baseline, before initiation of therapy, and in particular in the V1V2 fragment (distances ranging from 0.102 to 0.148). One HIV-1 single variant was concluded to be dominant in all of the HIV-1 regions analyzed, although some minor variants could be observed. The same tree structure was observed both at baseline and after six months of therapy. These are the first extended phylogenetic analyses performed on both members of a therapy-naïve couple within a few weeks of infection, and in which the effect of antiretroviral therapy on viral evolution was analyzed. Understanding which HIV-1 variants are most likely to be transmitted would allow a better understanding of viral evolution, possibly playing a role in vaccine design and prevention strategies.

Published
2021

184. Additional file 1 of MeltingPlot, a user-friendly online tool for epidemiological investigation using High Resolution Melting data

Author

Perini, Matteo, Gherard Batisti Biffignandi, Carlo, Domenico Di, Pasala, Ajay Ratan, Piazza, Aurora, Panelli, Simona, Zuccotti, Gian Vincenzo, and Comandatore, Francesco

Subjects
Data_FILES
Abstract

Additional file 1: This file contains a detailed description of the clustering algorithm, of the input file and of each output file created by the tool.

Published
2021
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185. RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs

Author

Rey, Federica, Messa, Letizia, Pandini, Cecilia, Maghraby, Erika, Barzaghini, Bianca, Garofalo, Maria, Micheletto, Giancarlo, Raimondi, Manuela Teresa, Bertoli, Simona, Cereda, Cristina, Zuccotti, Gian Vincenzo, Cancello, Raffaella, and Carelli, Stephana

Subjects
obesity, gender differences, lncRNAs, gene expression, Medicine, sex, computational prediction, bioinformatics, RNA-seq, metabolic diseases, transcriptome, Article
Abstract

Obesity is a multifactorial disease presenting sex-related differences including adipocyte functions, sex hormone effects, genetics, and metabolic inflammation. These can influence individuals' risk for metabolic dysfunctions, with an urgent need to perform sex-based analysis to improve prevention, treatment, and rehabilitation programs. This research work is aimed at characterizing the transcriptional differences present in subcutaneous adipose tissue (SAT) of five obesity affected men versus five obesity affected women, with an additional focus on the role of long non-coding RNAs. Through RNA-sequencing, we highlighted the presence of both coding and non-coding differentially expressed RNAs, and with numerous computational analyses we identified the processes in which these genes are implicated, along with their role in co-morbidities development. We report 51 differentially expressed transcripts, 32 of which were coding genes and 19 were non-coding. Using the WGCNA R package (Weighted Correlation Network Analysis, version 1.70-3), we describe the interactions between coding and non-coding RNAs, and the non-coding RNAs association with the insurgence of specific diseases, such as cancer development, neurodegenerative diseases, and schizophrenia. In conclusion, our work highlights a specific gender sex-related transcriptional signature in the SAT of obesity affected patients.

Published
2021

186. Congenital Adrenal Hyperplasia (CAH) and Gitelman Syndrome (GS): Overlapping Symptoms in an Uncommon Association

Author

Calcaterra, Valeria, Roberto, Giulia, La Rocca, Anna, Andrenacci, Beatrice, Rossi, Federico, Zuccotti, Gian Vincenzo, and Fabiano, Valentina

Subjects
Article Subject
Abstract

Background. Classical salt-wasting (SW) congenital adrenal hyperplasia (CAH) and Gitelman syndrome (GS) are two genetic conditions in which dyselectrolytemia may occur. No association between the two conditions has been previously described. Case Presentation. We present the case of a boy with a neonatal diagnosis of SW-CAH who showed low potassium blood levels from the age of 15 years. This electrolytic alteration was, at first, attributed to an excessive action of mineralocorticoid drugs. Due to persistence of hypokalemia, SLC12A3 whole genome sequencing was performed, showing a heterozygous C to T base pair substitution at position 965 in gene SLC12A3. This mutation is related to Gitelman syndrome with autosomal recessive transmission. Conclusions. SW-CAH and GS determine opposite values of potassium in the absence of specific therapy, with a natural tendency to compensate each other. The symptom overlap makes diagnosis difficult. Organic causes of hypokalemia in patients undergoing life-saving therapy should not be excluded.

Published
2021
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187. LncRNAs Associated with Neuronal Development and Oncogenesis Are Deregulated in SOD1-G93A Murine Model of Amyotrophic Lateral Sclerosis

Author

Rey, F, Marcuzzo, S, Bonanno, S, Bordoni, M, Giallongo, T, Malacarne, C, Cereda, C, Zuccotti, G, Carelli, S, Rey, Federica, Marcuzzo, Stefania, Bonanno, Silvia, Bordoni, Matteo, Giallongo, Toniella, Malacarne, Claudia, Cereda, Cristina, Zuccotti, Gian Vincenzo, Carelli, Stephana, Rey, F, Marcuzzo, S, Bonanno, S, Bordoni, M, Giallongo, T, Malacarne, C, Cereda, C, Zuccotti, G, Carelli, S, Rey, Federica, Marcuzzo, Stefania, Bonanno, Silvia, Bordoni, Matteo, Giallongo, Toniella, Malacarne, Claudia, Cereda, Cristina, Zuccotti, Gian Vincenzo, and Carelli, Stephana

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease caused in 10% of cases by inherited mutations considered “familial”. An ever-increasing amount of evidence is showing a fundamental role for RNA metabolism in ALS pathogenesis, and long non-coding RNAs (lncRNAs) appear to play a role in ALS development. Here, we aim to investigate the expression of a panel of lncRNAs (linc-Enc1, linc–Brn1a, linc–Brn1b, linc-p21, Hottip, Tug1, Eldrr, and Fendrr) which could be implicated in early phases of ALS. Via Real-Time PCR, we assessed their expression in a murine familial model of ALS (SOD1-G93A mouse) in brain and spinal cord areas of SOD1-G93A mice in comparison with that of B6.SJL control mice, in asymptomatic (week 8) and late-stage disease (week 18). We highlighted a specific area and pathogenetic-stage deregulation in each lncRNA, with linc-p21 being deregulated in all analyzed tissues. Moreover, we analyzed the expression of their human homologues in SH-SY5Y-SOD1-WT and SH-SY5Y-SOD1-G93A, observing a profound alteration in their expression. Interestingly, the lncRNAs expression in our ALS models often resulted opposite to that observed for the lncRNAs in cancer. These evidences suggest that lncRNAs could be novel disease-modifying agents, biomarkers, or pathways affected by ALS neurodegeneration.

Published
2021

194. Antibiotic Susceptibility, Virulome, and Clinical Outcomes in European Infants with Bloodstream Infections Caused by Enterobacterales

Author

Folgori, Laura, primary, Di Carlo, Domenico, additional, Comandatore, Francesco, additional, Piazza, Aurora, additional, Witney, Adam A., additional, Bresesti, Ilia, additional, Hsia, Yingfen, additional, Laing, Kenneth, additional, Monahan, Irene, additional, Bielicki, Julia, additional, Alvaro, Alessandro, additional, Zuccotti, Gian Vincenzo, additional, Planche, Tim, additional, Heath, Paul T., additional, and Sharland, Mike, additional

Published
2021
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195. Predictive Fat Mass Equations for Children With Inflammatory Bowel Disease

Author

Penagini, Francesca, primary, Leone, Alessandro, additional, Borsani, Barbara, additional, Bosetti, Alessandra, additional, Dilillo, Dario, additional, Rendo, Giulia, additional, Calcaterra, Valeria, additional, Bertoli, Simona, additional, Mora, Stefano, additional, Battezzati, Alberto, additional, Bedogni, Giorgio, additional, and Zuccotti, Gian Vincenzo, additional

Published
2021
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200. RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs

Author

Rey, Federica, primary, Messa, Letizia, additional, Pandini, Cecilia, additional, Maghraby, Erika, additional, Barzaghini, Bianca, additional, Garofalo, Maria, additional, Micheletto, Giancarlo, additional, Raimondi, Manuela Teresa, additional, Bertoli, Simona, additional, Cereda, Cristina, additional, Zuccotti, Gian Vincenzo, additional, Cancello, Raffaella, additional, and Carelli, Stephana, additional

Published
2021
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