151. Tissue-resident CD4+ T helper cells assist protective respiratory mucosal B and CD8+ T cell memory responses
- Author
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Chaofan Li, Yue Wu, Justin J. Taylor, Weiguo Cui, Alexander L. Dent, In Su Cheon, Jie Sun, Young Min Son, Yoshimasa Takahashi, Mark H. Kaplan, Yao Chen, Zheng Wang, and Yang Xin Fu
- Subjects
education.field_of_study ,CD40 ,T cell ,Cell ,Population ,Biology ,Virus ,medicine.anatomical_structure ,Immunology ,medicine ,biology.protein ,Cytotoxic T cell ,education ,Transcription factor ,CD8 - Abstract
The roles of CD4+T helper cells (TH) in shaping localized memory B and CD8+T cell immunity in the mucosal tissues are largely unexplored. Here, we report that lung THcells provide local assistance for the optimal development of tissue-resident memory B (BRM) and CD8+T (TRM) cells following the resolution of primary influenza virus infection. We identify a population of tissue-resident CD4+TH(akaTRH) cells that co-exhibit follicular T helper (TFH) and TRMcell features and mediate local help of CD4+T cells to B and CD8+T cells. Optimal TRHcell formation requires lung B cells and transcription factors involved in TFHor TRMdevelopment. Further, we show that TRHcells deliver local help to B and CD8 T cells through CD40L and IL-21-dependent mechanisms. Our data have uncovered a new tissue-resident THcell population that is specialized in assisting the development of mucosal protective B and CD8+T cell responsesin situ.
- Published
- 2020
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