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1,921 results on '"Yokota, Takashi"'

151. Nintedanib-Induced Renal Thrombotic Microangiopathy

Author

Fujita, Takeshi, primary, Nakagawa, Hideyuki, additional, Yokota, Takashi, additional, Umetani, Jun, additional, Nagawa, Daiki, additional, Nakata, Masamichi, additional, Narita-Kinjo, Ikuyo, additional, Murakami, Reiichi, additional, Shimada, Michiko, additional, Nakamura, Norio, additional, and Tomita, Hirofumi, additional

Published
2021
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153. Angiotensin‐converting enzyme inhibitor prevents skeletal muscle fibrosis in diabetic mice

Author

Kakutani, Naoya, primary, Takada, Shingo, additional, Nambu, Hideo, additional, Maekawa, Satoshi, additional, Hagiwara, Hikaru, additional, Yamanashi, Katsuma, additional, Obata, Yoshikuni, additional, Nakano, Ippei, additional, Fumoto, Yoshizuki, additional, Hata, Soichiro, additional, Furihata, Takaaki, additional, Fukushima, Arata, additional, Yokota, Takashi, additional, and Kinugawa, Shintaro, additional

Published
2021
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154. 780-P: Improved Mitochondrial Function by Luseogliflozin Prevents Pancreatic Beta-Cell Damage

Author

YAMAUCHI, YUKI, primary, NAKAMURA, AKINOBU, additional, YOKOTA, TAKASHI, additional, TAKAHASHI, KIYOHIKO, additional, KAWATA, SHINICHIRO, additional, TSUCHIDA, KAZUHISA, additional, OMORI, KAZUNO, additional, NOMOTO, HIROSHI, additional, KAMEDA, HIRAKU, additional, CHO, KYUYONG, additional, ANZAI, TOSHIHISA, additional, TANAKA, SHINYA, additional, TERAUCHI, YASUO, additional, MIYOSHI, HIDEAKI, additional, and ATSUMI, TATSUYA, additional

Published
2021
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156. Successive Occurrence of Large Earthquakes Along the Kuril Trench.

Author

Hashimoto, Tetsuo and Yokota, Takashi

Subjects
EARTHQUAKES, EARTHQUAKE magnitude, SHEAR waves, CROSS references (Information retrieval), TRENCHES, EMERGENCY management
Abstract

Large earthquakes have repeatedly occurred from Hokkaido to the Kamchatka Peninsula along the Kuril Trench. First, we confirmed the successive occurrence of large earthquakes of similar magnitude in nearby regions and within a short time interval using earthquake catalogs issued by international organizations. The searching criteria was whether a succeeding earthquake (Mw ≥ 7.75) had occurred within 500 km and 3 years of a preceding earthquake (Mw ≥ 7.70) in the period between 1890 and 2014. The pairs of successively occurring earthquakes were the June 1893 and March 1894 earthquakes, the September and November 1918 earthquakes, the October 1963 earthquakes, the October 1994 and December 1995 earthquakes, and the November 2006 and January 2007 earthquakes. These 5 pairs among the 21 large earthquakes were identified the successively occurring large earthquakes. Next, we tried to relocate the epicenters of the 1918 earthquakes because their epicenters had been changed in the version of the earthquake catalog referenced. We re-read the arrival times of the P and S waves from the seismograms of Japan Meteorological Agency and estimated the epicenters for the 1918 earthquakes from S-P times. The epicenters were a relative offset of about 160 km and the September event was near the epicenter of the 2006 Kuril earthquake. [ABSTRACT FROM AUTHOR]

Published
2022
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160. Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

Author

1000090374321, Yokota, Takashi, Kinugawa, Shintaro, Hirabayashi, Kagami, Yamato, Mayumi, Takada, Shingo, Suga, Tadashi, Nakano, Ippei, Fukushima, Arata, Matsushima, Shouji, Okita, Koichi, Tsutsui, Hiroyuki, 1000090374321, Yokota, Takashi, Kinugawa, Shintaro, Hirabayashi, Kagami, Yamato, Mayumi, Takada, Shingo, Suga, Tadashi, Nakano, Ippei, Fukushima, Arata, Matsushima, Shouji, Okita, Koichi, and Tsutsui, Hiroyuki

Abstract

Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 +/- 1.1 vs. 3.4 +/- 0.7 mu mol/L, p<0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.27.1 vs. 29.4 +/- 9.7 units/L, p<0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by (31)phosphorus- and (1)proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.

Published
2021

161. Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice

Author

Ohmura, Yoshinori, 1000070399848, Ishimori, Naoki, Saito, Akimichi, 1000090374321, Yokota, Takashi, Horii, Shunpei, Tokuhara, Satoshi, Iwabuchi, Kazuya, Tsutsui, Hiroyuki, Ohmura, Yoshinori, 1000070399848, Ishimori, Naoki, Saito, Akimichi, 1000090374321, Yokota, Takashi, Horii, Shunpei, Tokuhara, Satoshi, Iwabuchi, Kazuya, and Tsutsui, Hiroyuki

Abstract

The infiltration and activation of macrophages as well as lymphocytes within atherosclerotic lesion contribute to the pathogenesis of plaque rupture. We have demonstrated that invariant natural killer T (iNKT) cells, a unique subset of T lymphocytes that recognize glycolipid antigens, play a crucial role in atherogenesis. However, it remained unclear whether iNKT cells are also involved in plaque instability. Apolipoprotein E (apoE) knockout mice were fed a standard diet (SD) or a high-fat diet (HFD) for 8 weeks. Moreover, the SD- and the HFD-fed mice were divided into two groups according to the intraperitoneal injection of alpha-galactosylceramide (alpha GC) that specifically activates iNKT cells or phosphate-buffered saline alone (PBS). ApoE/J alpha 18 double knockout mice, which lack iNKT cells, were also fed an SD or HFD. Plaque instability was assessed at the brachiocephalic artery by the histological analysis. In the HFD group, alpha GC significantly enhanced iNKT cell infiltration and exacerbated atherosclerotic plaque instability, whereas the depletion of iNKT cells attenuated plaque instability compared to PBS-treated mice. Real-time PCR analyses in the aortic tissues showed that alpha GC administration significantly increased expressional levels of inflammatory genes such as IFN-gamma and MMP-2, while the depletion of iNKT cells attenuated these expression levels compared to those in the PBS-treated mice. Our findings suggested that iNKT cells are involved in the exacerbation of plaque instability via the activation of inflammatory cells and upregulation of MMP-2 in the vascular tissues.

Published
2021

163. Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

Author

Tsuda, Masaya, Fukushima, Arata, Matsumoto, Junichi, Takada, Shingo, Kakutani, Naoya, Nambu, Hideo, Yamanashi, Katsuma, Furihata, Takaaki, Yokota, Takashi, Okita, Koichi, Kinugawa, Shintaro, and Anzai, Toshihisa

Subjects
Male, lcsh:Diseases of the musculoskeletal system, Exercise intolerance, Heart failure, lcsh:QM1-695, Mitochondrial Proteins, Mice, Sirtuin 3, Skeletal muscle metabolism, Animals, Humans, Metabolomics, Muscle, Skeletal, Exercise, Aged, Fatty Acids, Acetylation, Original Articles, lcsh:Human anatomy, Middle Aged, Lipid Metabolism, Mitochondria, Muscle, Disease Models, Animal, Fatty acid oxidation, Heart Function Tests, Metabolome, Female, Original Article, Lysine acetylation, lcsh:RC925-935, Oxidation-Reduction
Abstract

Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play a central role in this intolerance, but the underlying mechanisms remain elusive. Lysine acetylation, a recently identified post‐translational modification, has emerged as a major contributor to the derangement of mitochondrial metabolism. We thus investigated whether mitochondrial protein acetylation is associated with impaired skeletal muscle metabolism and lowered exercise capacity in both basic and clinical settings of HF. Methods We first conducted a global metabolomic analysis to determine whether plasma acetyl‐lysine is a determinant factor for peak oxygen uptake (peak VO2) in HF patients. We then created a murine model of HF (n = 11) or sham‐operated (n = 11) mice with or without limited exercise capacity by ligating a coronary artery, and we tested the gastrocnemius tissues by using mass spectrometry‐based acetylomics. A causative relationship between acetylation and the activity of a metabolic enzyme was confirmed in in vitro studies. Results The metabolomic analysis verified that acetyl‐lysine was the most relevant metabolite that was negatively correlated with peak VO2 (r = −0.81, P < 0.01). At 4 weeks post‐myocardial infarction HF, a treadmill test showed lowered work (distance × body weight) and peak VO2 in the HF mice compared with the sham‐operated mice (11 ± 1 vs. 23 ± 1 J, P < 0.01; 143 ± 5 vs. 159 ± 3 mL/kg/min, P = 0.01; respectively). As noted, the protein acetylation of gastrocnemius mitochondria was 48% greater in the HF mice than the sham‐operated mice (P = 0.047). Acetylproteomics identified the mitochondrial enzymes involved in fatty acid β‐oxidation (FAO), the tricarboxylic acid cycle, and the electron transport chain as targets of acetylation. In parallel, the FAO enzyme (β‐hydroxyacyl CoA dehydrogenase) activity and fatty acid‐driven mitochondrial respiration were reduced in the HF mice. This alteration was associated with a decreased expression of mitochondrial deacetylase, Sirtuin 3, because silencing of Sirtuin 3 in cultured skeletal muscle cells resulted in increased mitochondrial acetylation and reduced β‐hydroxyacyl CoA dehydrogenase activity. Conclusions Enhanced mitochondrial protein acetylation is associated with impaired FAO in skeletal muscle and reduced exercise capacity in HF. Our results indicate that lysine acetylation is a crucial mechanism underlying deranged skeletal muscle metabolism, suggesting that its modulation is a potential approach for exercise intolerance in HF.

Published
2018

164. Use of Wearable Cardioverter Defibrillator Shortens the ICU Stay and Enables Safe Management in a General Ward

Author

Shoji, Yoshihiro, Sasaki, Shingo, Toyama, Yuichi, Nishizaki, Kimitaka, Kinjo, Takahiko, Ishida, Yuji, Endo, Tomohide, Nishizaki, Fumie, Itoh, Taihei, Yokota, Takashi, Yokoyama, Hiroaki, Yamada, Masahiro, Horiuchi, Daisuke, Kimura, Masaomi, Higuma, Takumi, Okumura, Ken, and Tomita, Hirofumi

Subjects
Secondary prevention, General ward, Ventricular tachycardia, Wearable cardioverter defibrillator, Ventricular fibrillation
Abstract

Wearable cardioverter-defibrillator （WCD） is an external device capable of automatic detection and treatment of ventricular tachycardia（VT）/ventricular fibrillation（ VF）. We examined whether WCD use for patients at high risk for VT/VF is associated with shortening the length of stay in the intensive care unit （ICU） and safe management in the general ward until implantable cardioverter-defibrillator（ ICD） implantation. From June 2012 to May 2014, ICD was implanted in 44 patients for secondary prevention of VT/VF （control group）. From June 2014 to May 2016, WCD was prescribed in 50 patients for secondary prevention, of which 29 patients had ICD implantation（ WCD group）. The median length（ 25th–75th percentiles） of the ICU stay was 3（ 1–7）days in the control and 0（ 0–1.5） days in the WCD group（ p

Published
2018

169. Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart

Author

Matsushima, Shouji, Kinugawa, Shintaro, Ide, Tomomi, Matsusaka, Hidenori, Inoue, Naoki, Ohta, Yukihiro, Yokota, Takashi, Sunagawa, Kenji, and Tsutsui, Hiroyuki

Subjects
Glutathione metabolism -- Research, Oxidative stress -- Research, Diabetes -- Care and treatment, Diabetes -- Research, Heart failure -- Research, Heart failure -- Drug therapy, Antioxidants -- Dosage and administration, Biological sciences
Abstract

Oxidative stress plays an important role in the structural and functional abnormalities of diabetic heart. Glutathione peroxidase (GSHPx) is a critical antioxidant enzyme that removes [H.sub.2][O.sub.2] in both the cytosol and mitochondia. We hypothesized that the overexpression of GSHPx gene could attenuate left ventricular (LV) remodeling in diabetes mellitus (DM). We induced DM by injection of streptozotocin (160 mg/kg ip) in male GSHPx transgenic mice (TG+DM) and nontransgenic wildtype littermates (WT+DM). GSHPx activity was higher in the hearts of TG mice compared with WT mice, with no significant changes in other antioxidant enzymes. LV thiobarbituric acid-reactive substances measured in TG+DM at 8 wk were significantly lower than those in WT+DM (58 [+ or -] 3 vs. 71 [+ or -] 5 nmol/g, P < 0.05). Heart rate and aortic blood pressure were comparable between groups. Systolic function was preserved normal in WT+DM and TG+DM mice. In contrast, diastolic function was impaired in WT+DM and was improved in TG+DM as assessed by the deceleration time of peak velocity of transmitral diastolic flow and the time needed for relaxation of 50% maximal LV pressure to baseline value (tan; 13.5 [+ or -] 1.2 vs. 8.9 [+ or -] 0.7 ms, P < 0.01). The TG+DM values were comparable with those of WT+Control (tau; 7.8 [+ or -] 0.2 ms). Improvement of LV diastolic function was accompanied by the attenuation of myocyte hypertrophy, interstitial fibrosis, and apoptosis. Overexpression of GSHPx gene ameliorated LV remodeling and diastolic dysfunction in DM. Therapies designed to interfere with oxidative stress might be beneficial to prevent cardiac abnormalities in DM. oxidative stress; diabetes mellitus; heart failure; antioxidant; hypertrophy; glutathione peroxidase

Published
2006

170. Impact of Inadequate Calorie Intake on Mortality and Hospitalization in Stable Patients with Chronic Heart Failure

Author

Obata, Yoshikuni, primary, Kakutani, Naoya, additional, Kinugawa, Shintaro, additional, Fukushima, Arata, additional, Yokota, Takashi, additional, Takada, Shingo, additional, Ono, Taisuke, additional, Sota, Takeshi, additional, Kinugasa, Yoshiharu, additional, Takahashi, Masashige, additional, Matsuo, Hisashi, additional, Matsukawa, Ryuichi, additional, Yoshida, Ichiro, additional, Yokota, Isao, additional, Yamamoto, Kazuhiro, additional, and Tsuchihashi-Makaya, Miyuki, additional

Published
2021
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177. Emergency operation for haemorrhagic gastric stump lymphoma

Author

Yokota, Takashi, Ishiyama, Shuichi, Kikuchi, Shu, and Yamauchi, Hidemi

Subjects
Malignant lymphomas -- Case studies -- Care and treatment -- Risk factors, Helicobacter infections -- Risk factors -- Care and treatment -- Case studies, Surgical anastomosis -- Risk factors -- Case studies, Anastomosis -- Risk factors -- Case studies, Health, Care and treatment, Case studies, Risk factors
Abstract

Code Number: is03038 ABSTRACT We report a case of malignant lymphoma developing in a gastric stump. The tumour was discovered 20 years after a subtotal gastrectomy. 29 such cases have [...]

Published
2003

181. Development of a Scenario Method to Identify Potential Problems Associated with the Issuance of the Nankai Tough Earthquake Informatio

Author

OHTANI, Ryu, primary, HYODO, Mamoru, additional, HAYASHI, Yoshinari, additional, HASHIMOTO, Manabu, additional, HORI, Takane, additional, KAWABATA, Nobumasa, additional, KUMAMOTO, Kunihiko, additional, IWATA, Takayoshi, additional, YOKOTA, Takashi, additional, TANIHARA, Kazunori, additional, IRIE, Sayaka, additional, and FUKUSHIMA, Yo, additional

Published
2021
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188. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

Author

Swoboda, Alexander, primary, Soukup, Robert, additional, Eckel, Oliver, additional, Kinslechner, Katharina, additional, Wingelhofer, Bettina, additional, Schörghofer, David, additional, Sternberg, Christina, additional, Pham, Ha T. T., additional, Vallianou, Maria, additional, Horvath, Jaqueline, additional, Stoiber, Dagmar, additional, Kenner, Lukas, additional, Larue, Lionel, additional, Poli, Valeria, additional, Beermann, Friedrich, additional, Yokota, Takashi, additional, Kubicek, Stefan, additional, Krausgruber, Thomas, additional, Rendeiro, André F., additional, Bock, Christoph, additional, Zenz, Rainer, additional, Kovacic, Boris, additional, Aberger, Fritz, additional, Hengstschläger, Markus, additional, Petzelbauer, Peter, additional, Mikula, Mario, additional, and Moriggl, Richard, additional

Published
2020
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190. Clinical impact of complete atrioventricular block in patients with ST ‐segment elevation myocardial infarction

Author

Kawamura, Yosuke, primary, Yokoyama, Hiroaki, additional, Kitayama, Kazutaka, additional, Miura, Naotake, additional, Hamadate, Misato, additional, Nagawa, Daiki, additional, Nozaka, Masashi, additional, Nakata, Masamichi, additional, Nishizaki, Fumie, additional, Hanada, Kenji, additional, Yokota, Takashi, additional, Yamada, Masahiro, additional, Higuma, Takumi, additional, and Tomita, Hirofumi, additional

Published
2020
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193. Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance

Author

Nambu, Hideo, primary, Takada, Shingo, additional, Maekawa, Satoshi, additional, Matsumoto, Junichi, additional, Kakutani, Naoya, additional, Furihata, Takaaki, additional, Shirakawa, Ryosuke, additional, Katayama, Takashi, additional, Nakajima, Takayuki, additional, Yamanashi, Katsuma, additional, Obata, Yoshikuni, additional, Nakano, Ippei, additional, Tsuda, Masaya, additional, Saito, Akimichi, additional, Fukushima, Arata, additional, Yokota, Takashi, additional, Nio-Kobayashi, Junko, additional, Yasui, Hironobu, additional, Higashikawa, Kei, additional, Kuge, Yuji, additional, Anzai, Toshihisa, additional, Sabe, Hisataka, additional, and Kinugawa, Shintaro, additional

Published
2020
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200. Activation of Stat3 by Cytokine Receptor gp130 Ventralizes Xenopus Embryos Independent of BMP-4

Author

Nishinakamura, Ryuichi, Matsumoto, Yuko, Matsuda, Takahiko, Ariizumi, Takashi, Heike, Toshio, Asashima, Makoto, and Yokota, Takashi

Subjects
Embryology -- Research, Cellular signal transduction -- Research, Cell receptors -- Research, Biological sciences
Abstract

Stat3 is one of the main signaling components of cytokine receptors, including gp130. Here we show that activation of cytokine receptor gp130 resulted in a dramatic ventralization of Xenopus embryos and that the ventralization correlated well with Stat3 activation potential of the receptor. This finding led to identification of Xenopus Stat3 (Xstat3), which showed a 95% homology to its murine and human counterparts, at the amino acid level, and was expressed from the one-cell stage throughout development. The mechanism of gp130/XStat3-mediated ventralization proved to be independent of BMP-4. gp130/Xstat3 stimulation inhibited Smad2-induced ectopic axis formation in embryos and Smad2-dependent luciferase activity. A dominant-negative Stat3, in contrast, dorsalized Xenopus embryos, resulting in ectopic axis formation. We propose that Stat3-mediated signaling has the capacity to modify dorsoventral patterning in the early development of Xenopus.

Published
1999

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