151. Formulation optimization of transdermal meloxicam potassium-loaded mesomorphic phases containing ethanol, oleic acid and mixture surfactant using the statistical experimental design methodology
- Author
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Pao-Chu Wu, Chia-Hsun Tsai, Yi-Hung Tsai, Hsin-Yeh Tsou, Yaw-Bin Huang, and Chi-Te Huang
- Subjects
Male ,Materials science ,Thiazines ,Pharmaceutical Science ,Bioengineering ,Administration, Cutaneous ,Meloxicam ,Dosage form ,Phase Transition ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Surface-Active Agents ,Colloid and Surface Chemistry ,Pulmonary surfactant ,medicine ,Animals ,Response surface methodology ,Physical and Theoretical Chemistry ,Transdermal ,Skin ,Drug Carriers ,Chromatography ,Ethanol ,Organic Chemistry ,Anti-Inflammatory Agents, Non-Steroidal ,Permeation ,Rats ,Oleic acid ,Thiazoles ,Distilled water ,chemistry ,medicine.drug ,Oleic Acid - Abstract
Response surface methodology (RSM) was used to develop and optimize the mesomorphic phase formulation for a meloxicam transdermal dosage form. A mixture design was applied to prepare formulations which consisted of three independent variables including oleic acid (X(1)), distilled water (X(2)) and ethanol (X(3)). The flux and lag time (LT) were selected as dependent variables. The result showed that using mesomorphic phases as vehicles can significantly increase flux and shorten LT of drug. The analysis of variance showed that the permeation parameters of meloxicam from formulations were significantly influenced by the independent variables and their interactions. The X(3) (ethanol) had the greatest potential influence on the flux and LT, followed by X(1) and X(2). A new formulation was prepared according to the independent levels provided by RSM. The observed responses were in close agreement with the predicted values, demonstrating that RSM could be successfully used to optimize mesomorphic phase formulations.
- Published
- 2011