Search

Background: The U.S. Hispanic/Latino population is heterogeneous both socioculturally and by the proportion of European, Indigenous American, and African ancestry of the regions from which individuals originate. A previous study reported that genetic ancestry was associated with breast cancer survival among Latinas, independent of sociodemographic and tumor characteristics, suggesting that a genetic factor associated with ancestry may affect breast cancer survival.Methods: We evaluated the association of genetic ancestry with breast cancer outcomes among 506 Latina women with invasive breast cancer in the Pathways Study, a cohort study within Kaiser Permanente, an integrated health care delivery system. Proportional hazards models were used to assess the effect of ancestry on breast cancer recurrence (53 events), breast cancer-specific mortality (31 events) and all-cause mortality (54 events), with a mean follow-up time of 6 years.Results: Indigenous American ancestry was not associated with breast cancer recurrence [HR = 1.00 per 10% increase; 95% confidence interval (CI), 0.86-1.16], breast cancer mortality (HR = 0.95; 95% CI, 0.77-1.17), or all-cause mortality (HR = 0.93; 95% CI, 0.80-1.08). Adjustment for sociodemographic variables, tumor characteristics, and treatment did not alter the associations.Conclusions: Our results suggest that previously reported differences in breast cancer survival by genetic ancestry may be overcome by improving health care access and/or quality.Impact: Improving health care access and quality may reduce breast cancer disparities among U.S. Latinas. Cancer Epidemiol Biomarkers Prev; 26(9); 1466-9. ©2017 AACR.

ObjectiveThis study aims to compare the efficacy of plasma kinetic loop resection of the prostate (PKRP) and transurethral vaporization of the prostate (TUVP) for the treatment of high-risk benign prostatic hyperplasia (BPH), and analyze the influence of the related factors on the operation of BPH.MethodsA total of 108 high-risk BPH patients diagnosed in our hospital from March 2018 to September 2021 were selected and randomly divided into an observation group and a control group, with 54 cases in each group. The control group was treated with TUVP, and the observation group was treated with PKRP. The international prostate symptom score (IPSS), quality of life (QOL) index, maximum urine flow rate (Qmax), and residual urine volume (RU) were observed before and after treatment. The general information such as age, educational level, residence, and residence status of the patient, as well as clinical information such as surgical method, nocturia frequency, preoperative IPSS score, RU, medical history, and prostate texture, were also recorded. All patients were followed up for 1 month, and complications were recorded.ResultsThe IPSS score, QOL score, and RU of patients in the two groups were lower after treatment than those before treatment, and the Qmax was higher than that before treatment (P

Abstract Empirical interatomic potentials require optimization of force field parameters to tune interatomic interactions to mimic ones obtained by quantum chemistry-based methods. The optimization of the parameters is complex and requires the development of new techniques. Here, we propose an INitial-DEsign Enhanced Deep learning-based OPTimization (INDEEDopt) framework to accelerate and improve the quality of the ReaxFF parameterization. The procedure starts with a Latin Hypercube Design (LHD) algorithm that is used to explore the parameter landscape extensively. The LHD passes the information about explored regions to a deep learning model, which finds the minimum discrepancy regions and eliminates unfeasible regions, and constructs a more comprehensive understanding of physically meaningful parameter space. We demonstrate the procedure here for the parameterization of a nickel–chromium binary force field and a tungsten–sulfide–carbon–oxygen–hydrogen quinary force field. We show that INDEEDopt produces improved accuracies in shorter development time compared to the conventional optimization method.

With an ageing population, healthy longevity is becoming an important scientific concern. The longevity phenomenon is closely related to the intestinal microflora and is highly complicated; it is challenging to identify and define the core gut microbiota associated with longevity. Therefore, in this study, 16S rRNA sequencing data were obtained from a total of 135 faecal samples collected as part of the latest sampling and pre-collection initiative in the Guangxi longevity area, and weighted gene co-expression network analysis (WGCNA) was used to find a mediumpurple3 network module significantly associated with the Guangxi longevity phenomenon. Five core genera, namely, Alistipes, Bacteroides, Blautia, Lachnospiraceae NK4A136 group, and Lactobacillus, were identified via network analysis and random forest (RF) in this module. Two potential probiotic strains, Lactobacillus fermentum and Bacteroides fragilis, were further isolated and screened from the above five core genera, and then combined and used as an intervention in naturally ageing mice. The results show a change in the key longevity gut microbiota in mice toward a healthy longevity state after the intervention. In addition, the results show that the probiotic combination effectively ameliorated anxiety and necrosis of hippocampal neuronal cells in senescent mice, improving their antioxidant capacity and reducing their inflammation levels. In conclusion, this longer-term study provides a new approach to the search for longevity hub microbiota. These results may also provide an important theoretical reference for the healthification of the intestinal microflora in the general population, and even the remodelling of the structure of the longevity-state intestinal microflora.

Vanadium-based materials hold significant promise as cathode materials for zinc-ion batteries owing to their high capacity and cost-effectiveness. However, their practical application is hindered by the sluggish diffusion kinetics of Zn2+ ions and the challenges of maintaining structural stability. Here, we report a high-performance ultrathin NH4V4O10 nanosheet cathode (denoted as SNVO) rich in oxygen vacancies. Introducing oxygen vacancies improves the diffusion ability of Zn2+ ions, effectively accelerates the reaction kinetics, and enhances the material's stability. Furthermore, according to the DFT results, oxygen vacancies greatly enhance the material's conductivity. The ultrathin size of SNVO enables a larger specific surface area, providing more active sites for reversible deintercalation of Zn2+, thereby increasing the specific capacity. SNVO exhibits an impressive discharge capacity of 513 mA h g−1 at 0.5 A g−1, coupled with outstanding cycle stability, retaining 94.6% of its initial capacity even after 1000 cycles at 10 A g−1. [ABSTRACT FROM AUTHOR]

Amidst the challenges posed by global climate change and accelerated urbanization, the structure and distribution of land use are shifting dramatically, exacerbating ecological and land-use conflicts, particularly in China. Effective land resource management requires accurate forecasts of land use and cover change (LUCC). However, the future trajectory of LUCC, influenced by climate change and urbanization, remains uncertain. This study developed an integrated multi-scenario framework by combining system dynamics and patch-generating land use simulation models to predict future LUCC in high-density urban regions under various Shared Socioeconomic Pathway (SSP)–Representative Concentration Pathway (RCP) scenarios. The results showed the following: (1) From 2020 to 2050, cultivated land, unused land, and water are projected to decrease, while construction land is expected to increase. (2) Future land use patterns exhibit significant spatial heterogeneity across three scenarios. Construction land will expand in all districts of Hangzhou, particularly in the main urban areas. Under the SSP585 scenario, the expansion of construction land is most significant, while it is the least under the SSP126 scenario. (3) Distinct factors drive the expansion of different land use types. The digital elevation model is the predominant factor for the expansion of forest and grassland, contributing 19.25% and 30.76%, respectively. Night light contributes the most to cultivated land and construction land, at 13.94% and 20.35%, respectively. (4) The average land use intensity (LUI) in central urban districts markedly surpasses that in the surrounding suburban areas, with Xiacheng having the highest LUI and Chun'an the lowest. Under the SSP126 scenario, the area with increased LUI is significantly smaller than under the SSP245 and SSP585 scenarios. These findings offer valuable guidance for sustainable planning and built environment management in Hangzhou and similarly situated urban centers worldwide. [ABSTRACT FROM AUTHOR]

The phenomenon of longevity in Guangxi of China proved to be closely relevant to its specific dietary habits, but the exact effects of this diet on health remain to be explored. In this work, fourteen screened volunteers with cardiovascular disease (CVD) risk followed a novel dietary pattern derived from centenarians of Guangxi, China for 2 weeks, then the effects of diet on human health were explored by measuring the health metrics and fecal metabolites. The results showed that the short-term dietary intervention significantly decreased the body weight, body mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), mean systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels, while it significantly increased high-density lipoprotein cholesterol (HDL-c) levels. Orthogonal partial least squares discriminant analysis (OPLS-DA) indicated a distinct separation in the fecal metabolic profiles of volunteers before and after the intervention. Nine of these metabolites showed significant differences, including two metabolites increased (butyrate and citrulline), seven metabolites decreased (threonine, choline, glycine, aspartate, alanine, N-acetylglutamic acid and lysine). Pathway and enrichment analysis showed that the reduction in CVD risk by dietary intervention mainly affected five pathways, which include arginine biosynthesis; aminoacyl-tRNA biosynthesis; glycine, serine and threonine metabolism; alanine, aspartate and glutamate metabolism; and valine, leucine and isoleucine biosynthesis. Herein, the Guangxi longevity dietary pattern can provide a feasible healthy diet strategy for reducing the CVD risk and human beings.Clinical Trial Registration[http://www.chictr.org.cn], identifier [ChiCTR220 0058216].

To increase public awareness and disseminate health information, the WHO and health departments worldwide have been visualizing the latest statistics on the spread of COVID-19 to increase awareness and thus reduce its spread. Within various sources, graphs are frequently used to illustrate COVID-19 datasets. Limited research has provided insights into the effect of different graphs on emotional stress and ineffective behavioral strategies from a cross-cultural perspective. The result of current research suggests a graph with a high proportion size of the colored area (e.g., stacked area graph) might increase people's anxiety and social distancing intentions; people in collectivist culture might have a high level of anxiety and social distancing intentions; the effect of different graphs on social distancing intentions is mediated by anxiety experienced. Theoretical contribution and practical implications on health communication were also discussed in this study.

Background and ObjectiveChronic spontaneous urticaria (CSU) is a histamine-mediated inflammatory skin disease, and second-generation non-sedating H1-antihistamines (nsAH) at licensed doses have long been the first-line therapy in CSU. However, about 50% of patients are resistant to nsAH, and the precise pathogenesis remains largely unknown but seems to be associated with low-level systemic or intestinal inflammation. We aim to determine the fecal microbial composition and clarify its correlation with the clinical profiles og CSU with nsAH resistance.MethodsA total of 25 CSU patients with or 19 CSU patients without nsAH resistance and 19 healthy controls (HC) were enrolled in this study. The intestinal microbiome was detected by 16S rRNA sequencing. The data were analyzed using R language software.ResultsSignificantly higher urticarial activity score for 7 days, stool calprotectin, erythrocyte sedimentation rate, serum C-reactive protein, and interleukin-6, but much lower alpha-diversity and evenness of fecal bacterial community were observed in CSU patients with nsAH resistance than in those without (P

Abstract Background Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cells remains unclear. The mammalian/mechanistic target of rapamycin (mTOR) and Poly (ADP-ribose) polymerase-1 (PARP-1) have become the primary targets for treating many neurodegenerative disorders. The aim of this study was to elucidate the mechanisms underlying light-induced photoreceptor cell death and whether the neuroprotective effects of mTOR and PARP-1 inhibition against death are mediated through apoptosis-inducing factor (AIF). Methods Propidium iodide (PI)/Hoechst staining, lentiviral-mediated short hairpin RNA (shRNA), Western blot analysis, cellular fraction separation, plasmid transient transfection, laser confocal microscopy, a mice model, electroretinography (ERG), and hematoxylin-eosin (H & E) staining were employed to explore the mechanisms by which rapamycin/3-Aminobenzamide (3AB) exert neuroprotective effects of mTOR/PARP-1 inhibition in light-injured retinas. Results A parthanatos-like death mechanism was evaluated in light-injured 661 W cells that are an immortalized photoreceptor-like cell line that exhibit cellular and biochemical feature characteristics of cone photoreceptor cells. The death process featured over-activation of PARP-1 and AIF nuclear translocation. Either PARP-1 or AIF knockdown played a significantly protective role for light-damaged photoreceptors. More importantly, crosstalk was observed between mTOR and PARP-1 signaling and mTOR could have regulated parthanatos via the intermediate factor sirtuin 1 (SIRT1). The parthanatos-like injury was also verified in vivo, wherein either PARP-1 or mTOR inhibition provided significant neuroprotection against light-induced injury, which is evinced by both structural and functional retinal analysis. Overall, these results elucidate the mTOR-regulated parthanatos death mechanism in light-injured photoreceptors/retinas and may facilitate the development of novel neuroprotective therapies for retinal degeneration diseases. Conclusions Our results demonstrate that inhibition of the mTOR/PARP-1 axis exerts protective effects on photoreceptors against visible-light–induced parthanatos. These protective effects are conducted by regulating the downstream factors of AIF, while mTOR possibly interacts with PARP-1 via SIRT1 to regulate parthanatos. Video Abstract Graphical Abstract Schematic diagram of mTOR interacting with PARP-1 to regulate visible light-induced parthanatos. Increased ROS caused by light exposure penetrates the nuclear membrane and causes nuclear DNA strand breaks. PARP-1 detects DNA breaks and synthesizes PAR polymers to initiate the DNA repair system that consumes a large amount of cellular NAD+. Over-production of PAR polymers prompts the release of AIF from the mitochondria and translocation to the nucleus, which leads to parthanatos. Activated mTOR may interact with PARP-1 via SIRT1 to regulate visible light-induced parthanatos.

The adaptive p-version finite element method is combined with bi-directional evolutionary structural optimization（ BESO） for the influence of calculation accuracy on the optimization result in the topology optimization process. According to the error control parameter setting,the element order is improved adaptively through the element energy error analysis,which effectively improves the finite element calculation accuracy,and the sensitivity filtering algorithm and the stabilization strategy are adopted to mitigate the checkerboard and iterative oscillation phenomenon. The feasibility of the method is verified by the example calculation of the minimum compliance topology optimization problem,the results show that the proposed method can improve the accuracy of topology optimization under rougher meshes,and obtain higher optimization efficiency and better optimization results.

Skin-resident stromal cells, including keratinocytes, fibroblasts, adipocytes, and immune cells including Langerhans cells, dendritic cells, T cells, and innate lymphoid cells, and their functional products work in concert to ensure the realization of skin barrier immunity. However, aging-induced immunosenescence predisposes the elderly to pruritic dermatoses, including type 2 inflammation-mediated. Inflammaging, characterized by chronic low level of pro-inflammatory cytokines released from senescent cells with the senescence-associated secretory phenotype (SASP), may drive immunosenescence and tangle with type 2 inflammatory dermatoses. The present mini-review summarizes current evidence on immunosenescence and type 2 inflammation in the skin and further focuses on future needs from an inflammaging perspective to clarify their complexity.

With the development of material synthesis technology, many artificial materials imitating natural materials have emerged in the construction industry. The processing technology of these materials’ surface imitating natural texture is becoming more and more realistic. Some materials are not made of sustainable material but use natural textures to imitate natural materials, attempting to bring users a sense of being close to nature and ecology to attract consumers to use it. However, the intention of use still depends on the user’s other factors like health, aesthetics, and environmental friendliness of the material. Therefore, the challenge for material manufacturers and designers is to understand people’s perceptions of these materials to increase their acceptance by users. This paper aims to investigate the user’s perception of materials (sustainable-unsustainable) to evaluate their perception of naturalness, environmental friendliness, and aesthetics through the visual senses. A total of 112 participants participated in the experiment which was divided into two groups (professional architects and non-professionals). The judgment of non-professionals on the environmental protection of materials imitating natural skin is relatively accurate, which is almost consistent with the judgment of professionals. Results show the importance of maintaining the naturalness of the surface texture in the material, which can enhance the user’s demand for a natural aesthetic feeling. Therefore, it is important to maintain the naturalness of surface texture in the process of material surface treatment. Users’ natural perception of materials will affect their aesthetic perception of materials.

Light-harvesting chlorophyll a/b-binding (LHC) superfamily proteins play a vital role in photosynthesis. Although the physiological and biochemical functions of LHC genes have been well-characterized, the structural evolution and functional differentiation of the products need to be further studied. In this paper, we report the genome-wide identification and phylogenetic analysis of LHC genes in photosynthetic organisms. A total of 1222 non-redundant members of the LHC family were identified from 42 species. According to the phylogenetic clustering of their homologues with Arabidopsis thaliana, they can be divided into four subfamilies. In the subsequent evolution of land plants, a whole-genome replication (WGD) event was the driving force for the evolution and expansion of the LHC superfamily, with its copy numbers rapidly increasing in angiosperms. The selection pressure of photosystem II sub-unit S (PsbS) and ferrochelatase (FCII) families were higher than other subfamilies. In addition, the transcriptional expression profiles of LHC gene family members in different tissues and their expression patterns under exogenous abiotic stress conditions significantly differed, and the LHC genes are highly expressed in mature leaves, which is consistent with the conclusion that LHC is mainly involved in the capture and transmission of light energy in photosynthesis. According to the expression pattern and copy number of LHC genes in land plants, we propose different evolutionary trajectories in this gene family. This study provides a basis for understanding the molecular evolutionary characteristics and evolution patterns of plant LHCs.