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Depression is the most common psychiatric disorder and is characterized by a deeply negative view of the world, oneself and the future, and this has been linked to negative ways in attention and comprehension and memory. Acupuncture has proven to have clinical efficacy in the treatment of depression, however, even with resources available for the treatment of this disorder, there are more difficult to eradicate symptoms, are expression of alterations in brain circuits, one of the most important factors for the expression of depression is stress, which has deleterious effects on vulnerable brain structures that impacts the neural circuits involved in chronic way, these neurobiological changes manifest themselves as characteristic behavioural and cognitive depression. In this study the neuroanatomical abnormalities, neural function and alteration of neurobiological circuits are described and analyzed its correspondence to the pathophysiology, organic phenomenology and syndromatic differentiation in traditional chinese medicine and based on this analysis is proposed treatment in scalp-acupuncture specific areas.

Shannon theory is revisited. The generalized channel capacity C = sup_X I(X;Y ) is checked with a negative conclusion.

The capacity region of a multiple access channel is discussed. It was found that orthogonal multiple access and non orthogonal multiple access have the same capacity region under the constraint of same sum power.

The concept of four diagnoses in traditional Chinese medicine (TCM) is considered the main diagnostic principle in TCM practice. The development of TCM should be based on inheritance and innovation. In recent years, studies on TCM diagnostic equipments have promoted the digital and objective development of TCM in both clinical practice and scientific research. BD-SZ/TCM Four-Diagnoses Auxiliary Apparatus (BD-SZ/TCM-FDAA) detects the pulse and analyzes the tongue through various devices. The health condition of a patient is evaluated by the four-diagnostic analysis system according to TCM theories. The results of TCM diagnosis and the recommended prescriptions are provided to assist in clinical treatment. Developing and integrating an acupuncture module into the BD-SZ/TCM-FDAA is important for the further promotion of TCM both at home and abroad. The prescription of the recommended acupoint also highlights the portable feature of the BD-SZ/TCM-FDAA. The development of an acupuncture module serves an active role in TCM clinical practice, teaching, and self-learning by TCM doctors. This article discusses the structure of the acupuncture module and its integration and optimization with the existing four-diagnoses syndrome-differentiation system of TCM.

The understanding of health has deepened with social development, scientific improvement, and environmental changes. The focus has changed from disease-oriented to health-oriented viewpoint. Hence, it is important to evaluate health using objective and accurate criteria. The four-diagnosis methods and syndrome differentiation are focused on differences among individuals according to the yin, yang, qi, and blood conditions. These differences are closely related to the constitution of a subject. The promotion of constitution identification among healthy and subhealthy groups and patients is beneficial for subjects to understand their body characteristics. It is important in daily health cultivation and disease prevention. Digital and objective information of a subject is acquired by the traditional Chinese medicine (TCM) Four-Diagnosis Auxiliary Apparatus efficiently and accurately. The automatic extraction and recognition of all the information is an important step in the diagnosis and constitution identification process by TCM.

Non orthogonal multiple access (NOMA) in the downlink is discussed in this letter. When combined with soft frequency reuse, NOMA is detrimental to user fairness by increasing the data rate of a near user at the cost of data rate of a far user.

MGCD0103, an isotype-selective HDACi, has been clinically evaluated for the treatment of hematologic malignancies and advanced solid tumors, alone and in combination with standard-of-care agents. In this study, we developed a serum metabolomic method based on gas chromatography-mass spectrometry (GC-MS) to evaluate the effect of intragastric administration of MGCD0103 on rats. The MGCD0103 group rats were given 20, 40, 80 mg/kg of MGCD0103 by intragastric administration each day for 7 days. Pattern recognition analysis, including both principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) revealed that intragastric administration of MGCD0103 induced metabolic perturbations. As compared to the control group, the levels of L-alanine, L-isoleucine, and L-leucine of MGCD0103 group decreased. The results indicate that metabolomic methods based on GC-MS may be useful to elucidate side effect of MGCD0103 through the exploration of biomarkers (L-alanine, L-isoleucine, and L-leucine). According to the pathological changes of liver at difference dosage, MGCD0103 is hepatotoxic and its toxity is dose-dependent.