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Big data has become valuable property for enterprises and enabled various intelligent applications. Today, it is common to host data in big data platforms (e.g., Spark), where developers can submit scripts to process the original and intermediate data tables. Meanwhile, it is highly desirable to manage the data to comply with various privacy requirements. To enable flexible and automated privacy policy enforcement, we propose TaintStream, a fine-grained taint tracking framework for Spark-like big data platforms. TaintStream works by automatically injecting taint tracking logic into the data processing scripts, and the injected scripts are dynamically translated to maintain a taint tag for each cell during execution. The dynamic translation rules are carefully designed to guarantee non-interference in the original data operation. By defining different semantics of taint tags, TaintStream can enable various data management applications such as access control, data retention, and user data erasure. Our experiments on a self-crafted benchmarksuite show that TaintStream is able to achieve accurate cell-level taint tracking with a precision of 93.0% and less than 15% overhead. We also demonstrate the usefulness of TaintStream through several real-world use cases of privacy policy enforcement.

Serverless computing is an emerging paradigm for cloud computing, gaining traction in a wide range of applications such as video processing and machine learning. This new paradigm allows developers to focus on the development of the logic of serverless computing based applications (abbreviated as serverless-based applications) in the granularity of function, thereby freeing developers from tedious and error-prone infrastructure management. Meanwhile, it also introduces new challenges on the design, implementation, and deployment of serverless-based applications, and current serverless computing platforms are far away from satisfactory. However, to the best of our knowledge, these challenges have not been well studied. To fill this knowledge gap, this paper presents the first comprehensive study on understanding the challenges in developing serverless-based applications from the developers’ perspective. We mine and analyze 22,731 relevant questions from Stack Overflow (a popular Q&A website for developers), and show the increasing popularity trend and the high difficulty level of serverless computing for developers. Through manual inspection of 619 sampled questions, we construct a taxonomy of challenges that developers encounter, and report a series of findings and actionable implications. Stakeholders including application developers, researchers, and cloud providers can leverage these findings and implications to better understand and further explore the serverless computing paradigm.

Background Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the hypothesis that epidermal growth factor-like domain-containing protein 6 (EGFL6), an angiogenic factor, also functions in bone marrow mesenchymal stem cells (BMSCs), playing a key role in the interaction between osteogenesis and angiogenesis. Methods We evaluated how EGFL6 affects angiogenic activity of human umbilical cord vein endothelial cells (HUVECs) via proliferation, transwell migration, wound healing, and tube-formation assays. Alkaline phosphatase (ALP) and Alizarin Red S (AR-S) were used to assay the osteogenic potential of BMSCs. qRT-PCR, western blotting, and immunocytochemistry were used to evaluate angio- and osteo-specific markers and pathway-related genes and proteins. In order to determine how EGFL6 affects angiogenesis and osteogenesis in vivo, EGFL6 was injected into fracture gaps in a rat tibia distraction osteogenesis (DO) model. Radiography, histology, and histomorphometry were used to quantitatively evaluate angiogenesis and osteogenesis. Results EGFL6 stimulated both angiogenesis and osteogenic differentiation through Wnt/β-catenin signaling in vitro. Administration of EGFL6 in the rat DO model promoted CD31hiEMCNhi type H-positive capillary formation associated with enhanced bone formation. Type H vessels were the referred subtype involved during DO stimulated by EGFL6. Conclusion EGFL6 enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis. Thus, increasing EGFL6 secretion appeared to underpin the therapeutic benefit by promoting angiogenesis-coupled bone formation. These results imply that boosting local concentrations of EGFL6 may represent a new strategy for the treatment of compromised fracture healing and bone defect restoration.

In enterprise organizations, the Bring-Your-Own-Device (BYOD) requirement has become prevalent as employees use their own mobile devices to process the workflow-oriented tasks. Consequently, it calls for approaches that can quickly develop and integrate mobile user interactions into existing business processes, and adapt to various contexts. However, designing, developing, and deploying adaptive and mobile-oriented user interfaces for existing process engines are non-trivial, and require significant systematic efforts. To address this issue, we present a novel middleware-based approach, called MUIT, to developing and deploying the Mobility, User Interactions and Tasks into WS-BPEL engines. MUIT provides a Domain-Specific Language (DSL) that provides some intuitive facilities to support the declarative development of adaptive, mobile-oriented, and Web-based user interfaces in WS-BPEL. The DSL can significantly reduce developers' manual efforts of developing user interactions by preventing arbitrarily mixed code, and its runtime supports satisfactory user experiences. Additionally, MUIT can be seamlessly integrated into WS-BPEL without intrusions of existing process instances. We implement a proof-of-concept prototype by integrating MUIT into the commodity WS-BPEL-based Apusic Platform, and evaluate the performance and usability of MUIT platform.

With the increasing popularity of blockchain technologies in recent years, blockchain-based decentralized applications (DApps for short in this paper) have been rapidly developed and widely adopted in many areas, being a hot topic in both academia and industry. Despite of the importance of DApps, we still have quite little understanding of DApps along with its ecosystem. To bridge the knowledge gap, this paper presents the first comprehensive empirical study of blockchain-based DApps to date, based on an extensive dataset of 995 Ethereum DApps and 29,846,075 transaction logs over them. We make a descriptive analysis of the popularity of DApps, summarize the patterns of how DApps use smart contracts to access the underlying blockchain, and explore the worth-addressing issues of deploying and operating DApps. Based on the findings, we propose some implications for DApp users to select proper DApps, for DApp developers to improve the efficiency of DApps, and for blockchain vendors to enhance the support of DApps.

Mobile Web applications (a.k.a., Web apps) stand for an important trend for next-generation Internet-based software. Currently popular mobile Web apps need to be adapted to various and ever-changing contexts and personalized user requirements. Based on our over-decade research experiences and practice on the Internetware paradigm, this position article describes an Internetware-oriented approach to designing, developing, and deploying situational mobile Web apps, by synthesizing the resources and services of mobile and cloud. Guided by a novel Service-Model-View-Controller (SMVC) software model, a mobile Web app is organized into a well-defined structure that facilitates adaptation including online/offline data access, computation offloading, user interface optimization, hybrid composition, etc. We provide efficient runtime support spanning mobile and cloud to make mobile Web apps more flexibly adaptive. The proof-of-concept evaluation demonstrates that our approach can benefit end-users with optimized user experience of mobile Web apps.

Mobile users spend an extensive amount of time on typing. A more efficient text input instrument brings a significant enhancement of user experience. Deep learning techniques have been recently applied to suggesting the next words of input, but to achieve more accurate predictions, these models should be customized for individual users. Personalization is often at the expense of privacy concerns. Existing solutions require users to upload the historical logs of their input text to the cloud so that a deep learning predictor can be trained. In this work, we propose a novel approach, called DeepType, to personalize text input with better privacy. The basic idea is intuitive: training deep learning predictors on the device instead of on the cloud, so that the model makes personalized and private data never leaves the device to externals. With DeepType, a global model is first trained on the cloud using massive public corpora, and our personalization is done by incrementally customizing the global model with data on individual devices. We further propose a set of techniques that effectively reduce the computation cost of training deep learning models on mobile devices at the cost of negligible accuracy loss. Experiments using real-world text input from millions of users demonstrate that DeepType significantly improves the input efficiency for individual users, and its incurred computation and energy costs are within the performance and battery restrictions of typical COTS mobile devices.

Sequential recommendation techniques are considered to be a promising way of providing better user experience in mobile commerce by learning sequential interests within user historical interaction behaviors. However, the recently increasing focus on privacy concerns, such as the General Data Protection Regulation (GDPR), can significantly affect the deployment of state-of-the-art sequential recommendation techniques, because user behavior data are no longer allowed to be arbitrarily used without the user’s explicit permission. To address the issue, this paper proposes DeepRec, an on-device deep learning framework of mining interaction behaviors for sequential recommendation without sending any raw data or intermediate results out of the device, preserving user privacy maximally. DeepRec constructs a global model using data collected before GDPR and fine-tunes a personal model continuously on individual mobile devices using data collected after GDPR. DeepRec employs the model pruning and embedding sparsity techniques to reduce the computation and network overhead, making the model training process practical on computation-constraint mobile devices. Evaluation results show that DeepRec can achieve comparable recommendation accuracy to existing centralized recommendation approaches with small computation overhead and up to 10x reduction in network overhead.

To improve app quality and nip the potential threats in the bud, modern app markets have released strict guidelines along with app vetting process before app publishing. However, there has been growing evidence showing the ineffectiveness of app vetting, making potentially harmful and policy-violation apps sneak into the market from time to time. Therefore, app removal is a common practice, and market maintainers have to remove undesired apps from the market periodically in a reactive manner. Although a number of reports and news media have mentioned removed apps, our research community still lacks the comprehensive understanding of the landscape of this kind of apps. To fill the void, in this paper, we present a large-scale and longitudinal study of removed apps in iOS app store. We first make great efforts to record daily snapshot of iOS app store continuously in a span of 1.5 years. By comparing each two consecutive snapshots, we have collected the information of over 1 million removed apps with their accurate removed date. This comprehensive dataset enables us to characterize the overall landscape of removed apps. We observe that, although most of the removed apps are low-quality apps (e.g., outdated and abandoned), a number of the removed apps are quite popular. We further investigate the practical reasons leading to the removal of such popular apps, and observe several interesting reasons, including ranking fraud, fake description, and content issues, etc. More importantly, most of these mis-behaviors can be reflected on app meta information including app description, app review, and ASO keywords. It motivates us to design an automated approach to flagging the removed apps. Experiment result suggests that, even without accessing to the bytecode of mobile apps, we can identify the removed apps with good performance (F1=83%). Furthermore, we are able to flag the removed apps in advance as long as their inappropriate behaviors appear in their metadata. We believe our approach can work as a whistle blower that pinpoints policy-violation behaviors timely, which will be quite effective in improving the app maintenance process.

Mobile gambling app, as a new type of online gambling service emerging in the mobile era, has become one of the most popular and lucrative underground businesses in the mobile app ecosystem. Since its born, mobile gambling app has received strict regulations from both government authorities and app markets. However, to the best of our knowledge, mobile gambling apps have not been investigated by our research community. In this paper, we take the first step to fill the void. Specifically, we first perform a 5-month dataset collection process to harvest illegal gambling apps in China, where mobile gambling apps are outlawed. We have collected 3,366 unique gambling apps with 5,344 different versions. We then characterize the gambling apps from various perspectives including app distribution channels, network infrastructure, malicious behaviors, abused third-party and payment services. Our work has revealed a number of covert distribution channels, the unique characteristics of gambling apps, and the abused fourth-party payment services. At last, we further propose a “guilt-by-association” expansion method to identify new suspicious gambling services, which help us further identify over 140K suspicious gambling domains and over 57K gambling app candidates. Our study demonstrates the urgency for detecting and regulating illegal gambling apps.

Background: Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the hypothesis that epidermal growth factor-like domain-containing protein 6 (EGFL6), an angiogenic factor, also functions in bone marrow mesenchymal stem cells (BMSCs) and plays a key role in the interaction between osteogenesis angiogenesis.Methods: We evaluated how EGFL6 affects angiogenic activity of human umbilical cord vein endothelial cells (HUVECs) via proliferation, transwell migration, wound healing, and tube-formation assays. Alkaline phosphatase (ALP) and Alizarin Red S (AR-S) were used to assay the osteogenic potential of BMSCs. qRT-PCR, western blotting, and immunocytochemistry were used to evaluate angio- and osteo-specific markers and pathway-related genes and proteins. In order to determine how EGFL6 affects angiogenesis and osteogenesis in vivo, EGFL6 was injected into fracture gaps in a rat tibia distraction osteogenesis (DO) model. Radiography, histology, and histomorphometry were used to quantitatively evaluate angiogenesis and osteogenesis. Results: EGFL6 stimulated both angiogenesis and osteogenic differentiation through Wnt/β-catenin signaling in vitro. Administration of EGFL6 in the rat DO model promoted CD31hiEMCNhi type H-positive capillary formation associated with enhanced bone formation. Type H vessels were the referred subtype involved during DO stimulated by EGFL6.Conclusion: EGFL6 enhanced osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis, thus exerting therapeutic benefit by increasing EGFL6 secretion to promote angiogenesis-coupled bone formation. These results imply that boosting local concentrations of EGFL6 may represent a new strategy for the treatment of compromised fracture healing and bone defect restoration.

Deep Learning (DL) is finding its way into a growing number of mobile software applications. These software applications, named as DL based mobile applications (abbreviated as mobile DL apps) integrate DL models trained using large-scale data with DL programs. A DL program encodes the structure of a desirable DL model and the process by which the model is trained using training data. Due to the increasing dependency of current mobile apps on DL, software engineering (SE) for mobile DL apps has become important. However, existing efforts in SE research community mainly focus on the development of DL models and extensively analyze faults in DL programs. In contrast, faults related to the deployment of DL models on mobile devices (named as deployment faults of mobile DL apps) have not been well studied. Since mobile DL apps have been used by billions of end users daily for various purposes including for safety-critical scenarios, characterizing their deployment faults is of enormous importance. To fill the knowledge gap, this paper presents the first comprehensive study on the deployment faults of mobile DL apps. We identify 304 real deployment faults from Stack Overflow and GitHub, two commonly used data sources for studying software faults. Based on the identified faults, we construct a fine-granularity taxonomy consisting of 23 categories regarding to fault symptoms and distill common fix strategies for different fault types. Furthermore, we suggest actionable implications and research avenues that could further facilitate the deployment of DL models on mobile devices., Accepted by the 43rd International Conference on Software Engineering (ICSE 2021). Please include ICSE in any citations

Public edge platforms have drawn increasing attention from both academia and industry. In this study, we perform a first-of-its-kind measurement study on a leading public edge platform that has been densely deployed in China. Based on this measurement, we quantitatively answer two critical yet unexplored questions. First, from end users' perspective, what is the performance of commodity edge platforms compared to cloud, in terms of the end-to-end network delay, throughput, and the application QoE. Second, from the edge service provider's perspective, how are the edge workloads different from cloud, in terms of their VM subscription, monetary cost, and resource usage. Our study quantitatively reveals the status quo of today's public edge platforms, and provides crucial insights towards developing and operating future edge services.

Deep learning (DL) has become a key component of modern software. In the "big model" era, the rich features of DL-based software substantially rely on powerful DL models, e.g., BERT, GPT-3, and the recently emerging GPT-4, which are trained on the powerful cloud with large datasets. Hence, training effective DL models has become a vital stage in the whole software lifecycle. When training deep learning models, especially those big models, developers need to parallelize and distribute the computation and memory resources amongst multiple devices in the training process, which is known as distributed deep learning training, or distributed training for short. However, the unique challenges that developers encounter in distributed training process have not been studied in the software engineering community. Given the increasingly heavy dependence of current DL-based software on distributed training, this paper aims to fill in the knowledge gap and presents the first comprehensive study on developers' issues in distributed training. To this end, we analyze 1,131 real-world developers' issues about using these frameworks reported on Stack Overflow and GitHub. We construct a fine-grained taxonomy consisting of 30 categories regarding the fault symptoms and summarize common fix patterns for different symptoms. Based on the results, we suggest actionable implications on research avenues that can potentially facilitate the distributed training to develop DL-based software, such as focusing on the frequent and common fix patterns when designing testing or debugging tools, developing efficient testing and debugging techniques for communication configuration along with the synthesis of network configuration analysis, designing new multi-device checkpoint-and-replay techniques to help reproduction, and designing serverless APIs for cloud platforms., Comment: Accepted by ACM Transactions on Software Engineering and Methodology (TOSEM 2023). Please include TOSEM in any citations

Distraction osteogenesis (DO) is a powerful method to reconstruct segmented bone defects in the extremities. However, the main shortcoming of DO is the time-consuming consolidation period. To shorten the consolidation process, two biocompatible inorganic ions, strontium and silicone, were applied to design a biocompatible material to enhance bone mineralization ability during DO. In the present study, we integrated strontium into a one-pot synthesis of mesoporous silica nanoparticles to obtain strontium-doped mesoporous silica nanoparticles characterized by a homogeneous spherical morphology and uniform ion-releasing dynamics. This dual-ion releasing osteogenic and angiogenic drug delivery system was investigated to accelerate mineralization in DO. Osteogenesis was promoted by activation of the Wnt/β-catenin pathway, while bone resorption was inhibited by reduction of the osteoclastogenic factor RANKL/OPG. In addition, angiogenesis may have been enhanced indirectly by secretion of vascular endothelial growth factor (VEGF) from bone marrow stem cells. Therefore, strontium-doped mesoporous silica nanoparticles could be a potential biomaterial candidate for accelerating consolidation during DO.

Human pose estimation is a key technique for many vision-based mobile applications. Yet existing multi-person pose-estimation methods fail to achieve a satisfactory user experience on commodity mobile devices such as smartphones, due to their long model-inference latency. In this paper, we propose MobiPose, a system designed to enable real-time multi-person pose estimation on mobile devices through three novel techniques. First, MobiPose takes a motion-vector-based approach to fast locate the human proposals across consecutive frames by fine-grained tracking of joints of human body, rather than running the expensive human-detection model for every frame. Second, MobiPose designs a mobile-friendly model that uses lightweight multi-stage feature extractions to significantly reduce the latency of pose estimation without compromising the model accuracy. Third, MobiPose leverages the heterogeneous computing resources of both CPU and GPU to execute the pose estimation model for multiple persons in parallel, which further reduces the total latency. We have implemented the MobiPose system on off-the-shelf commercial smartphones and conducted comprehensive experiments to evaluate the effectiveness of the proposed techniques. Evaluation results show that MobiPose achieves over 20 frames per second pose estimation with 3 persons per frame, and significantly outperforms the state-of-the-art baseline, with a speedup of up to 4.5X and 2.8X in latency on CPU and GPU, respectively, and an improvement of 5.1% in pose-estimation model accuracy. Furthermore, MobiPose achieves up to 62.5% and 37.9% energy-per-frame saving on average in comparison with the baseline on mobile CPU and GPU, respectively.

As COVID-19 has been spreading across the world since early 2020, a growing number of malicious campaigns are capitalizing the topic of COVID-19. COVID-19 themed cryptocurrency scams are increasingly popular during the pandemic. However, these newly emerging scams are poorly understood by our community. In this paper, we present the first measurement study of COVID-19 themed cryptocurrency scams. We first create a comprehensive taxonomy of COVID-19 scams by manually analyzing the existing scams reported by users from online resources. Then, we propose a hybrid approach to perform the investigation by: 1) collecting reported scams in the wild; and 2) detecting undisclosed ones based on information collected from suspicious entities (e.g., domains, tweets, etc). We have collected 195 confirmed COVID-19 cryptocurrency scams in total, including 91 token scams, 19 giveaway scams, 9 blackmail scams, 14 crypto malware scams, 9 Ponzi scheme scams, and 53 donation scams. We then identified over 200 blockchain addresses associated with these scams, which lead to at least 330K US dollars in losses from 6,329 victims. For each type of scams, we further investigated the tricks and social engineering techniques they used. To facilitate future research, we have released all the well-labelled scams to the research community.

Service providers usually maintain multiple kinds of service clients, such as desktop Web pages, mobile Web pages, and mobile native apps, to satisfy different user requirements. Understanding how users consume services via these heterogeneous clients is important for service providers to efficiently manage back-end resources. However, little has been known about such facts. To bridge the knowledge gap, in this paper, we conduct the first empirical study on service access patterns via heterogeneous clients. Our study is based on two large-scale real-world datasets of launching events from both app and Web clients of 986 services, involving a sample of 60 million users within 7 days. We analyze the characteristics of service access patterns from both spatial view and temporal view. We explore how users consume online services through different service clients, and to what extent their usage behavior patterns vary when consuming the same service. Our findings provide better understandings for heterogeneous service clients that can facilitate the development, configuration, deployment and maintenance of service back-end.

Low-cost wireless cameras are growing rapidly. With the help of advanced machine learning models (e.g., CNNs), those videos exhibit high business and social values, e.g., for retailing planning [18], wildlife study [21], and traffic monitoring [19, 25]. However, with high compute need, traditional video analytics systems [14, 15, 26, 27] require all videos to be uploaded to a backend server, which stresses the scarce network bandwidth between cameras and servers.

Objectives High glucose (HG)–mediated bone marrow mesenchymal stem cell (BMSC) dysfunction plays a key role in impaired bone formation induced by type 1 diabetes mellitus (T1DM). Morroniside is an iridoid glycoside derived from the Chinese herb Cornus officinalis, and it has abundant biological activities associated with cell metabolism and tissue regeneration. However, the effects and underlying mechanisms of morroniside on HG‐induced BMSC dysfunction remain poorly understood. Materials and methods Alkaline phosphatase (ALP) staining, ALP activity and Alizarin Red staining were performed to assess the osteogenesis of BMSCs. Quantitative real‐time PCR and Western blot (WB) were used to investigate the osteo‐specific markers, receptor for advanced glycation end product (RAGE) signalling and glyoxalase‐1 (Glo1). Additionally, a T1DM rat model was used to assess the protective effect of morroniside in vivo. Results Morroniside treatment reverses the HG‐impaired osteogenic differentiation of BMSCs in vitro. Morroniside suppressed advanced glycation end product (AGEs) formation and RAGE expression by triggering Glo1. Moreover, the enhanced osteogenesis due to morroniside treatment was partially blocked by the Glo1 inhibitor, BBGCP2. Furthermore, in vivo, morroniside attenuated bone loss and improved bone microarchitecture accompanied by Glo1 upregulation and RAGE downregulation. Conclusions These findings suggest that morroniside attenuates HG‐mediated BMSC dysfunction partly through the inhibition of AGE‐RAGE signalling and activation of Glo1 and may be a potential treatment for diabetic osteoporosis., Under pathological diabetic conditions, chronic hyperglycaemia leads to the increased accumulation of advanced glycation end products (AGEs) by methylglyoxal (MG) and activation of receptor for advanced glycation end product (RAGE) signalling. Subsequently, AGE‐RAGE activation induces bone marrow mesenchymal stem cell (BMSC) dysfunction due to a combination of decreased osteogenic differentiation of BMSCs and enhanced inflammation, reactive oxygen species generation and BMSC apoptosis. Finally, reduced osteogenesis of BMSCs causes impaired bone formation in type 1 diabetes. Morroniside triggers Glo1 to degrade MG, thus downregulating AGE‐RAGE signalling, rectifying these downstream detrimental effects and attenuating BMSC dysfunction induced by high glucose.

Sentiment classification typically relies on a large amount of labeled data. In practice, the availability of labels is highly imbalanced among different languages. To tackle this problem, cross-lingual sentiment classification approaches aim to transfer knowledge learned from one language that has abundant labeled examples (i.e., the source language, usually English) to another language with fewer labels (i.e., the target language). The source and the target languages are usually bridged through off-the-shelf machine translation tools. Through such a channel, cross-language sentiment patterns can be successfully learned from English and transferred into the target languages. This approach, however, often fails to capture sentiment knowledge specific to the target language. In this paper, we employ emojis, which are widely available in many languages, as a new channel to learn both the cross-language and the language-specific sentiment patterns. We propose a novel representation learning method that uses emoji prediction as an instrument to learn respective sentiment-aware representations for each language. The learned representations are then integrated to facilitate cross-lingual sentiment classification.

Elf is a runtime for an energy-constrained camera to continuously summarize video scenes as approximate object counts. Elf's novelty centers on planning the camera's count actions under energy constraint. (1) Elf explores the rich action space spanned by the number of sample image frames and the choice of per-frame object counters; it unifies errors from both sources into one single bounded error. (2) To decide count actions at run time, Elf employs a learning-based planner, jointly optimizing for past and future videos without delaying result materialization. Tested with more than 1,000 hours of videos and under realistic energy constraints, Elf continuously generates object counts within only 11% of the true counts on average. Alongside the counts, Elf presents narrow errors shown to be bounded and up to 3.4x smaller than competitive baselines. At a higher level, Elf makes a case for advancing the geographic frontier of video analytics.

Federated learning (FL) is an emerging, privacy-preserving machine learning paradigm, drawing tremendous attention in both academia and industry. A unique characteristic of FL is heterogeneity, which resides in the various hardware specifications and dynamic states across the participating devices. Theoretically, heterogeneity can exert a huge influence on the FL training process, e.g., causing a device unavailable for training or unable to upload its model updates. Unfortunately, these impacts have never been systematically studied and quantified in existing FL literature. In this paper, we carry out the first empirical study to characterize the impacts of heterogeneity in FL. We collect large-scale data from 136k smartphones that can faithfully reflect heterogeneity in real-world settings. We also build a heterogeneity-aware FL platform that complies with the standard FL protocol but with heterogeneity in consideration. Based on the data and the platform, we conduct extensive experiments to compare the performance of state-of-the-art FL algorithms under heterogeneity-aware and heterogeneity-unaware settings. Results show that heterogeneity causes non-trivial performance degradation in FL, including up to 9.2% accuracy drop, 2.32 × lengthened training time, and undermined fairness. Furthermore, we analyze potential impact factors and find that device failure and participant bias are two potential factors for performance degradation. Our study provides insightful implications for FL practitioners. On the one hand, our findings suggest that FL algorithm designers consider necessary heterogeneity during the evaluation. On the other hand, our findings urge system providers to design specific mechanisms to mitigate the impacts of heterogeneity.

Conventional road signs convey very concise and static visual information to human drivers, and bear retroreflective coating for better visibility at night. This paper introduces RetroI2V - a novel infrastructure-to-vehicle (I2V) communication and networking system that renovates conventional road signs to convey additional and dynamic information to vehicles while keeping intact their original functionality. In particular, RetroI2V exploits the retroreflective coating of road signs and establishes visible light backscattering communication (VLBC), and further coordinates multiple concurrent VLBC sessions among road signs and approaching vehicles. RetroI2V features a suite of novel VLBC designs including late-polarization, complementary optical signaling and polarization-based differential reception which are crucial to avoid flickering and achieve long VLBC range, as well as a decentralized MAC protocol that make practical multiple access in highly mobile and transient I2V settings. Experimental results from our prototyped system show that RetroI2V supports up to 101 m communication range and efficient multiple access at scale.

Background The posterior tibial artery perforator (PTAP) flap is a useful tool for reconstruction of soft tissue defects in the leg. However, the size and reliability of the flap largely depends on the quality of the perforator by which the flap is supplied, and the sensory recovery of the flap is limited. In this study, the anatomy of the saphenous nerve branches and their accompanying vessels was investigated, and a free extended PTAP flap with the neurovascular plexus of a saphenous nerve branch was designed for large soft tissue and sensory reconstruction in a series of clinical cases. Methods Sixteen adult cadaveric legs perfused with red latex in the femoral artery were dissected. The number and location of the saphenous nerve branches and the features of their accompanying vessels were dissected and studied. From January 2016 to December 2017, six patients with soft tissue defects ranged from 8 × 2.5 cm to 21 × 4 cm were repaired by the free extended PTAP flap. The patients' average age was 48 years. The causes of the defects included machine injuries in three patients and traffic injuries in the other three. The defects located at the hand in three cases, foot in two cases, and ankle in one case. The flap was designed based on the perforators of the posterior tibial artery and included a branch of saphenous nerve. The perforator pedicle and the nerve branch were connected to the vessels and nerve in the recipient site, respectively. Results The saphenous nerve gave off 5.8 ± 1.1 branches, with a relatively constant one issuing 8.1 ± 0.7 cm distal to the medial femoral condyle. Every nerve branch had an accompanying vessel, which connected with the PTAPs and supplied the skin. The size of the flap ranged from 10 × 3.5 cm to 23 × 5 cm. All of the flaps survived completely without complications. Follow-up varied from 6 to 12 months. All the patients obtained cold/hot sensation and pain sensation. The results of Semmes-Weinstein monofilament test ranged from 4.31(2 g) to 5.46 (26 g), and the 2-point discrimination test varied from 20 to 35 mm. Conclusion The free extended PTAP flap, containing the saphenous nerve branch and its accompanying vessels, may be an alternative for large soft tissue reconstruction with improved sensation recovery.

The Spatio-Temporal Traffic Prediction (STTP) problem is a classical problem with plenty of prior research efforts that benefit from traditional statistical learning and recent deep learning approaches. While STTP can refer to many real-world problems, most existing studies focus on quite specific applications, such as the prediction of taxi demand, ridesharing order, traffic speed, and so on. This hinders the STTP research as the approaches designed for different applications are hardly comparable, and thus how an application-driven approach can be generalized to other scenarios is unclear. To fill in this gap, this paper makes three efforts: (i) we propose an analytic framework, called STAnalytic, to qualitatively investigate STTP approaches regarding their design considerations on various spatial and temporal factors, aiming to make different application-driven approaches comparable; (ii) we design a spatio-temporal meta-model, called STMeta, which can flexibly integrate generalizable temporal and spatial knowledge identified by STAnalytic, (iii) we build an extensively large-scale STTP benchmark platform including ten datasets with five scenarios to quantitatively measure the generalizability of STTP approaches. In particular, we implement STMeta with different deep learning techniques, and STMeta demonstrates better generalizability than state-of-the-art approaches by achieving lower prediction error on average across all the datasets.

A promising paradigm to regenerative medicine involves the application of biomaterials, which makes a spurt of progress in the past 20 years. Of various biomaterials, decellularized biomaterials possess good biocompatibility and great potential for clinical translation. The role of decellularized biomaterials in tissue repair and regeneration is not just the structure and delivering bioactive matters, what's even important, the interaction between biomaterials and the internal environment, especially the scaffold-immune system interactions, which is the initial response to in vivo implantation. Consequently, we have reviewed the immunogenicity of decellularized scaffolds derived from various tissues and organs, and immunomodulatory effects of decellularized scaffolds in the view of innate and adaptive immune systems. Finally, we discuss the influence factors of host responses mediated by decellularized biomaterials. Decellularized scaffold-immune interactions can provide important mechanistic insight into the development of decellularized materials in vivo, penetrating into the knowledge is the necessary precondition for the clinical translation.

The prevalent smartphones have become the major entrance to accessing services on the Internet. On smartphones, users can have two options as the clients, i.e., native apps and Web apps. There have been several debates about native apps and Web apps. However, major service providers such as Google, Amazon , and Facebook provide both native apps and Web apps to end-users. Essentially, the performance differences between these two types of apps haven’t been addressed. Indeed, the performance differences make non-trivial impacts on apps development, deployment, and distribution. In this article, we conduct a measurement study on the performance of native apps and Web apps on Android smartphones. Specifically, we want to explore given the same functionalities, do Web apps always perform poorly compared to native apps. We select 328 services from some popular providers, covering various domains such as e-commerce, map, social networking, and entertainment. With HTTP-level trace analysis, we demystify the workflows on how native apps and Web apps deliver services on mobile devices, respectively. Then, we characterize the performance differences between native apps and Web apps with the metrics including the number of requests, response time, data drain, and energy consumption. We find that the performance of Web apps is better than native apps in more than 31 percent cases. Our derived knowledge can suggest some recommendations to improve the performance for mobile apps.

The prevalence of smart mobile devices has promoted the popularity of mobile applications (a.k.a. apps). Supporting mobility has become a promising trend in software engineering research. This article presents an empirical study of behavioral service profiles collected from millions of users whose devices are deployed with Wandoujia, a leading Android app-store service in China. The dataset of Wandoujia service profiles consists of two kinds of user behavioral data from using 0.28 million free Android apps, including (1) app management activities (i.e., downloading, updating, and uninstalling apps) from over 17 million unique users and (2) app network usage from over 6 million unique users. We explore multiple aspects of such behavioral data and present patterns of app usage. Based on the findings as well as derived knowledge, we also suggest some new open opportunities and challenges that can be explored by the research community, including app development, deployment, delivery, revenue, etc.

Web browsing is always a key requirement of Internet users. Current mobile Web apps can contain computation-intensive JavaScript logics and thus affect browsing performance. Learning from our over-decade research and development experiences of the Internetware paradigm, we present the novel and generic i - Jacob approach to improving the performance of mobile Web browsing with effective JavaScript-code offloading. Our approach proposes a programming abstraction to make mobile Web situational and adaptive to contexts, by specifying the computation-intensive and “ offloadable ” code, and develops a platform-independent lightweight runtime spanning the mobile devices and the cloud. We demonstrate the efficiency of i - Jacob with some typical computation-intensive tasks over various combinations of hardware, operating systems, browsers, and network connections. The improvements can reach up to 49× speed-up in response time and 90% saving in energy.

Anti-adhesion barriers such as films and hydrogels used to wrap repaired tendons are important for preventing the formation of adhesion tissue after tendon surgery. However, sliding of the tendon can compress the adjacent hydrogel barrier and cause it to rupture, which may then lead to unexpected inflammation. Here, a self-healing and deformable hyaluronic acid (HA) hydrogel was constructed as a peritendinous anti-adhesion barrier. Matrix metalloproteinase-2 (MMP-2)-degradable gelatin-methacryloyl (GelMA) microspheres (MSs) encapsulated with Smad3-siRNA nanoparticles were entrapped within the HA hydrogel to inhibit fibroblast proliferation and prevent peritendinous adhesion. Silencing effect of Smad3-siRNA nanoparticles was around 75% towards targeted gene. The mean adhesion scores of composite barrier group were 1.67±0.51 and 2.17±0.75 by macroscopic and histological evaluation, respectively. Furthermore, GelMA MSs were responsively degraded by upregulation of MMP-2, achieving on-demand release of siRNA nanoparticles to inhibit the formation of adhesion tissue. The proposed self-healing hydrogel anti-adhesion barrier with MMP-2-responsive drug release behavior is highly effective for decreasing inflammation and inhibiting tendon adhesion. Therefore, this research provides a new strategy for the development of safe and effective anti-adhesion barriers. This article is protected by copyright. All rights reserved.

Numerous complains have been made by Android users who severely suffer from the sluggish response when interacting with their devices. However, very few studies have been conducted to understand the user-perceived latency or mitigate the UI-lagging problem. In this paper, we conduct the first systematic measurement study to quantify the user-perceived latency using typical interaction-intensive Android apps in running with and without background workloads. We reveal the insufficiency of Android system in ensuring the performance of foreground apps and therefore design a new system to address the insufficiency accordingly. We develop a lightweight tracker to accurately identify all delay-critical threads that contribute to the slow response of user interactions. We then build a resource manager that can efficiently schedule various system resources including CPU, I/O, and GPU, for optimizing the performance of these threads. We implement the proposed system on commercial smartphones and conduct comprehensive experiments to evaluate our implementation. Evaluation results show that our system is able to significantly reduce the user-perceived latency of foreground apps in running with aggressive background workloads, up to 10x, while incurring negligible system overhead of less than 3.1 percent CPU and 7 MB memory.

Imperfect Web resource loading prevents mobile Web browsing from providing satisfactory user experience. In this article, we design and implement the SWAROVsky system to address three main issues of current inefficient Web resource loading: (1) on-demand and thus slow loading of sub-resources of webpages ; (2) duplicated loading of resources with different URLs but the same content ; and (3) redundant loading of the same resource due to improper cache configurations . SWAROVsky employs a dual-proxy architecture that comprises a remote cloud-side proxy and a local proxy on mobile devices. The remote proxy proactively loads webpages from their original Web servers and maintains a resource loading graph for every single webpage. Based on the graph, the remote proxy is capable of deciding which resources are “really” needed for the webpage and their loading orders, and thus can synchronize these needed resources with the local proxy of a client efficiently and timely. The local proxy also runs an intelligent and light-weight algorithm to identify resources with different URLs but the same content, and thus can avoid duplicated downloading of the same content via network. Our system can be used with existing Web browsers and Web servers, and does not break the normal semantics of a webpage. Evaluations with 50 websites show that on average our system can reduce the page load time by 43.1 percent and the network data transmission by 57.6 percent, while imposing marginal system overhead.

Redundant transfer of resources is a critical issue for compromising the performance of mobile Web applications (a.k.a., apps) in terms of data traffic, load time, and even energy consumption. Evidence demonstrates that the current cache mechanisms are far from satisfactory. With lessons learned from how native apps manage their resources, in this article, we present the ReWAP approach to fundamentally reducing redundant transfers by restructuring the resource loading of mobile Web apps. ReWAP is based on an efficient resource-packaging mechanism where stable resources are encapsulated and maintained into a package, and such a package shall be loaded always from the local storage and updated by explicitly refreshing. By retrieving and analyzing the update of resources, ReWAP maintains resource packages that can accurately identify which resources can be loaded from the local storage for a considerably long period. ReWAP also provides a wrapper for mobile Web apps to enable loading and updating resource packages in the local storage as well as loading resources from resource packages. ReWAP can be easily and seamlessly deployed into existing mobile Web architectures with minimal modifications, and is transparent to end-users. We evaluate ReWAP based on continuous 15-day access traces of 50 mobile Web apps randomly chosen from Alexa top 500 ranking list. Compared to the original mobile Web apps with cache enabled, ReWAP can significantly reduce the data traffic, with the median saving up to 51 percent. In addition, ReWAP can incur only very minor runtime overhead of the client-side browsers and thus does not compromise user experiences.

App marketplaces host millions of mobile apps that are downloaded billions of times. Investigating how people manage mobile apps in their everyday lives creates a unique opportunity to understand the behavior and preferences of mobile device users, infer the quality of apps, and improve user experience. Existing literature provides very limited knowledge about app management activities, due to the lack of app usage data at scale. This article takes the initiative to analyze a very large app management log collected through a leading Android app marketplace. The dataset covers 5 months of detailed downloading, updating, and uninstallation activities, which involve 17 million anonymized users and 1 million apps. We present a surprising finding that the metrics commonly used to rank apps in app stores do not truly reflect the users’ real attitudes. We then identify behavioral patterns from the app management activities that more accurately indicate user preferences of an app even when no explicit rating is available. A systematic statistical analysis is designed to evaluate machine learning models that are trained to predict user preferences using these behavioral patterns, which features an inverse probability weighting method to correct the selection biases in the training process.

As healthcare solutions and augmented monitoring of human mobility overlap with the new concepts of the Internet of Things, an emerging area of interest leverages sensor networks that monitor personal health data and human activity. This special issue presents research innovation that address advances in this evolving paradigm of Internet of Bodies/Internet of Sports.

EOSIO has become one of the most popular blockchain platforms since its mainnet launch in June 2018. In contrast to the traditional PoW-based systems (e.g., Bitcoin and Ethereum), which are limited by low throughput, EOSIO is the first high throughput Delegated Proof of Stake system that has been widely adopted by many decentralized applications. Although EOSIO has millions of accounts and billions of transactions, little is known about its ecosystem, especially related to security and fraud. In this paper, we perform a large-scale measurement study of the EOSIO blockchain and its associated DApps. We gather a large-scale dataset of EOSIO and characterize activities including money transfers, account creation and contract invocation. Using our insights, we then develop techniques to automatically detect bots and fraudulent activity. We discover thousands of bot accounts (over 30% of the accounts in the platform) and a number of real-world attacks (301 attack accounts). By the time of our study, 80 attack accounts we identified have been confirmed by DApp teams, causing 828,824 EOS tokens losses (roughly $2.6 million) in total.

Mobile app ecosystem has gained giant success in providing services on mobile devices to facilitate almost all aspects in our daily life. However, the whole-package installation and dramatically increasing package size are now preventing users from trying more apps. To address the issue, many lightweight frameworks have emerged, enabling to provide the experience of instant service consumption where apps are of small size and no installation is needed to consuming services provided by the apps. In this paper, we conduct the first empirical study on instant service consumption on mobile devices. We focus on one of the most popular frameworks, quick apps, which are proposed and supported by nine mainstream mobile phone manufacturers in China. Quick apps are implemented with Web-based technologies, and run as native apps without the need of installation. We find that quick apps have much smaller size and only provide a limited set of services compared to their corresponding native apps. Then, we characterize the performance differences between quick apps and native apps in terms of launching time, data drain, and network connections, when the two kinds of apps provide the same services. Our observations reveal that quick apps perform better than native apps thanks to its much smaller size and less functionalities in a single page. Finally, we propose a machine learning based approach to helping developers construct the quick app from an existing native app.

Due to the limited battery capacity of mobile devices, various CPU power governors and dynamic frequency adjustment schemes have been proposed to reduce CPU energy consumption. However, most such schemes are app-oblivious, ignoring an important fact that real-world applications often exhibit multiple execution phases that perform different functionality and may request different amounts of hardware resources. Having a unified app-level frequency setting for different phases of an application may not be energy efficient enough and may even violate the desirable latency performance required by certain phases. Motivated by this observation, in this paper, we present PIFA, which is an intelligent Phase Identification and Frequency Adjustment framework for energy-efficient and time-sensitive mobile computing. PIFA addresses two major challenges of fully automatically identifying different execution phases of an application and efficiently integrating the phase identification results for runtime frequency adjustment. We have fully implemented PIFA on the Android platform. An extensive set of experiments using real-world Android applications from multiple app categories demonstrate that PIFA achieves closely better performance than the desired latency requirement specified for each phase, while dramatically reducing energy consumption (e.g., >30% energy reduction for most apps) and incurring rather small runtime overhead (e.g.

Automated-test-generation tools generate test cases to enable dynamic analysis of Android apps, such as functional testing. These tools build a GUI model to describe the app states during the app execution, and generate a script that performs actions on UI widgets to form a test case. However, when the test cases are re-executed, the apps under analysis often do not behave consistently. The major reasons for such limited reproducibility are due to (1) backend-service dependencies that cause non-determinism in app behaviors and (2) the severe fragmentation of Android platform (i.e., the alarming number of different Android OS versions in vendor-customized devices). To address these challenges, we design and implement Paladin, a novel system that generates reproducible test cases for Android apps. The key insight of Paladin is to provide a GUI model that leverages the structure of the GUI view tree to identify equivalent app states, since the structure can tolerate the changes on the UI contents for an app behavior performed in different test executions. Based on the model, Paladin can search the view tree to locate the desired UI widgets to trigger events and drive the app exploration to reach the desired app states, making the test cases reproducible. Evaluation results on real apps show that Paladin could reach a much higher reproduction ratio than the state-of-the-art tools when the generated test cases are re-executed across different device configurations. In addition, benefiting from the reproducible capability, Paladin is able to cover more app behaviors compared with the existing tools.

Recently, several JavaScript-based deep learning frameworks have emerged, making it possible to perform deep learning tasks directly in browsers. However, little is known on what and how well we can do with these frameworks for deep learning in browsers. To bridge the knowledge gap, in this paper, we conduct the first empirical study of deep learning in browsers. We survey 7 most popular JavaScript-based deep learning frameworks, investigating to what extent deep learning tasks have been supported in browsers so far. Then we measure the performance of different frameworks when running different deep learning tasks. Finally, we dig out the performance gap between deep learning in browsers and on native platforms by comparing the performance of TensorFlow.js and TensorFlow in Python. Our findings could help application developers, deep-learning framework vendors and browser vendors to improve the efficiency of deep learning in browsers.