151. Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
- Author
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Xinghua Liu, Hong-Yu Jiang, Ke Wu, Gu Junnan, Yinghao Cao, Li Liu, Jiliang Wang, Mao Fuwei, Huili Li, Hongli Liu, Song-Qing Ke, Xinying Li, Yang-Ting He, Kailin Cai, Hang Li, Deng Shenghe, and Shuang Yao
- Subjects
Oncology ,medicine.medical_specialty ,Colorectal cancer ,business.industry ,Apolipoprotein A1-apolipoprotein B ratio ,Prognosis ,medicine.disease ,High-density lipoprotein cholesterol-low-density lipoprotein cholesterol ratio ,Surgery ,Retrospective Study ,Liptein cholesterol-apolipoprotein score ,Internal medicine ,Plasma lipids ,medicine ,lipids (amino acids, peptides, and proteins) ,business ,Value (mathematics) - Abstract
BACKGROUND At present, the value of lipid indicators in evaluating the prognosis of colorectal cancer is still relatively limited. AIM To evaluate the value of a novel parameter for colorectal cancer (CRC) prognosis scoring based on preoperative serum lipid levels. METHODS Four key serum lipid factors, namely, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), were detected. Two representative ratios, HDL-C-LDL-C ratio (HLR) and ApoA1-ApoB ratio (ABR) were calculated. The relationship of these parameters with the prognosis of CRC patients including progression-free survival (PFS) and overall survival (OS) was analyzed by Kaplan-Meier plot and Cox proportional hazards regression. A novel lipoprotein cholesterol-apolipoprotein (LA) score based on HLR and ABR was established and its value in prognosis evaluation for CRC patients was explored. RESULTS Multivariate Cox proportional hazards regression analysis of PFS and OS showed that HDL-C, ApoA1, HLR, and ABR were positively associated with the prognosis of CRC patients. LA score was independently associated with a good prognosis in resectable CRC patients. Data processing of a dummy variable showed that the prognosis of patients with higher LA scores is better than that with lower LA scores. CONCLUSION The newly established LA score might serve as a better predictor of the prognosis of resectable CRC patients.
- Published
- 2021