778 results on '"Xiaoyan Lin"'
Search Results
152. Mathematical formula identification and performance evaluation in PDF documents.
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Xiaoyan Lin, Liangcai Gao, Zhi Tang 0001, Josef B. Baker, and Volker Sorge
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- 2014
- Full Text
- View/download PDF
153. Pain expression assessment based on a locality and identity aware network
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Xiaoyan Lin, Shengfu Yang, Xuwu Xin, Xin Zheng, and Xiaowu Li
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QA76.75-76.765 ,Signal Processing ,Locality ,Photography ,Identity (social science) ,Pain expression ,Computer software ,Computer Vision and Pattern Recognition ,Electrical and Electronic Engineering ,TR1-1050 ,Psychology ,Social psychology ,Software - Abstract
In clinical medicine, the pain feeling is a significant indicator for the medical condition of patients. Of late, automatic pain assessment methods have received more and more interests. Many researchers proposed corresponding methods and achieved impressive results. However, they always ignore the locality and individual differences of painful expression. Therefore, a locality and identity aware network (LIAN) for pain assessment is presented here. Concretely, for the locality characteristic, a locality aware module consisting of a two‐branch structure, feature and attention branches, is presented. The former learns pain features by a deep network, while the latter guides the pain features to focus on the discriminational regions of pain. As for the individual differences, an identity aware module with a multi‐task method is proposed to represent identity‐related information to achieve identity‐invariant pain assessment. Extensive experiments on public databases show the superiority of LIAN in pain assessment.
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- 2021
154. TEAD is required for DNA repair independent of its transcriptional function
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Philamer C. Calses, Victoria C. Pham, Erik Verschueren, Sietske T. Bakker, Benjamin Haley, Chad Liu, Matthew T. Chang, Noelyn Kljavin, Trent Hinkle, Jianing Zou, Cuicui Yan, Xia Song, Xiaoyan Lin, Rebecca Rowntree, Alan Ashworth, Jennie R. Lill, and Anwesha Dey
- Abstract
The TEA domain family members 1-4 (TEADs) are major transcription factors for YAP/TAZ transcription activators in the Hippo pathway, regulating many biological processes, including development, tissue homeostasis, and tumorigenesis through target genes. Their amplification/upregulation correlates with poor prognosis in cancer patients. Although the Hippo pathway continues to be elucidated, it is clear that TEAD largely exerts its actions via transcriptional regulation. Here, we uncover an unexpected role for TEADs in the DNA damage response. Using comparative mass spectrometry, we demonstrate that TEADs interact with several DNA repair proteins. We further show that TEADs form DNA damage-induced nuclear foci that co-localize with DNA damage markers, γH2AX, and RIF1. We also found that TEADs are required for resistance to DNA damage, maintaining genome stability, and resolution of double strand break repair that is independent from the Hippo pathway and its transcriptional role. Our results establish a new role for TEADs in DNA repair and therefore, highlight a critical consideration in therapeutically targeting the Hippo pathway.
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- 2022
155. The real-world therapeutic analysis of first-line immunotherapy in Chinese patients with Drive Gene Positive for Advanced Non-Small Cell lung cancer
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Lei Liu, Jing Zhao, Xiaoli Zhuo, Jingjiang Lai, Jingliang Wang, Fengxian Jiang, Wei Xu, Fang Luan, Shuping Yang, Xiaoyan Lin, and Guobin Fu
- Abstract
Background: Immune checkpoint inhibitors are widely used in advanced non-small cell lung cancer, but in some studies it has been shown that patients with genetic mutations didn't benefit from immunotherapy. Our aim was to explore the efficacy of programmed death-1 (PD-1) and programmed death-receptor-ligand 1 (PD-L1) inhibitors in the first-line treatment of advanced NSCLC with driver gene mutations in real-world settings and to analyze potential prognostic correlates. Methods: Retrospective analysis of patients with advanced NSCLC treated with PD-1/PD-L1 inhibitors at Shandong Provincial Hospital from May 2019 to October 2021, identification of patient driver gene mutation status using ARMS-PCR and NGS. The basic clinical characteristics, objective response rate (ORR), progression free survival (PFS) and other clinical data of patients were also collected to evaluate the clinical efficacy and potential prognostic factors of treatment for patients with driver gene mutations. Results: A total of 86 NSCLC patients were enrolled in the study. The main pathological type of patients was adenocarcinoma (57.0%), the overall mutation rate was 43.0% (n=37), including KRAS (n=20), TP53 (n=18), EGFR (n=3), BRAF (n=3),Her-2 (n=3), MET (n=3),ROS1 (n=1), NRAS (n=1), with an overall ORR of 16.10% and a disease control rate (DCR) of 82.23%.At the time of follow-up cutoff , the median PFS of the whole group of patients was 13.2 (95%CI:10.6-15.8) months.Patients with negative driver mutations treated with ICIs had a longer median progression-free survival compared to patients with mutations (13.5 vs 11.6 months, P=0.50). The survival benefit varied among the different mutation subgroups. Overall, NSCLC patients with driver gene mutation had slightly lower PFS than patients with negative mutation with first-line immunotherapy, but there was no statistical difference. PD-L1 expression level was positively correlated with PFS of immunotherapy. Conclusions: In this real-world setting, the efficacy of first-line immunotherapy in NSCLC patients with driver gene mutations is similar to that in mutation negative patients, immune monotherapy may be more effective in patients with positive driver mutations, and immune efficacy is positively correlated with PD-L1 expression levels.
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- 2022
156. lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p
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Guo Wang, Xiaoyan Lin, Han Han, Hongxu Zhang, Xiaoli Li, Mei Feng, and Chunming Jiang
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Mice ,MicroRNAs ,Cell Line, Tumor ,Autophagy ,Animals ,Humans ,Bioengineering ,RNA, Long Noncoding ,General Medicine ,Glioblastoma ,Applied Microbiology and Biotechnology ,Biotechnology ,Cell Proliferation - Abstract
Glioblastoma multiforme (GBM) is a malignant cancer with severely poor survival, and the cells continue to thrive during hypoxia and toxic stress through autophagy. To validate the oncogenic role of long noncoding RNA H19 in GBM progression and examine whether autophagy and/or miR-491-5p participate in the process. The expression of H19 and autophagy-related genes in GBM and healthy control tissues was assessed via quantitative polymerase chain reaction. In addition, cell viability, proliferation, apoptosis and autophagy were respectively determined via cell counting kit-8 assay, clone formation assay, flow cytometry, western blotting and green fluorescent protein-microtubule-associated protein 1 light chain 3 alpha fluorescence analysis
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- 2022
157. Clinical characteristics and prognostic factors of patients with non-small cell lung cancer having HER2 alterations
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Xiaoli Zhuo, Honglin Guo, Jun Ma, Jingjiang Lai, Lei Liu, Ke Yin, Jing Zhao, Jingliang Wang, Fengxian Jiang, Wei Xu, Xiaotian Yuan, Xiaoyan Lin, and Guobin Fu
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Cancer Research ,Oncology ,General Medicine - Abstract
Human epidermal growth factor 2 (HER2) alterations are found in approximately 2%-5% of non-small cell lung cancer (NSCLC). This study aimed to evaluate the clinical characteristics of patients with NSCLC having HER2 alterations in China and the differences compared with Western counterparts and also perform a prognostic analysis.A total of 1300 patients diagnosed with NSCLC from January 2017 to December 2020 were included. Their clinical characteristics were retrospectively recorded. The gene expression profiles and clinical information of 20 patients having altered HER2 were downloaded from the Cancer Genome Atlas database and compared, and the prognostic factors affecting the Chinese population were analyzed. If tissues were sufficient, the overexpression was assessed by immunohistochemical staining.Among 39 (3.0%) patients with HER2 alterations, 31 patients (79.5%) had HER2 mutations. HER2 insertion mutation in exon 20 was the most common type (A775_G776 ins YVMA). Seven patients (17.9%) had amplification, and one had both. The HER2 kinase domain was most commonly mutated. A majority of patients in the study were young-aged with no smoking history; 66.7% had stage III/IV adenocarcinoma. Compared with Chinese patients, HER2 alterations in Western counterparts were mostly associated with old age, previous smoking, and stages I and II at diagnosis. The most common type of HER2 alteration was HER2 amplification; one patient had coexistence of HER2 gene amplification and fusion. The furin-like cysteine-rich region was most commonly mutated. The median overall survival (OS) of the Chinese patients was 41 months. The univariate analysis showed that age 60 years, no surgical treatment, no liver or renal cysts on imaging, and maximum tumor diameter ≥ 4.25 cm were significantly associated with poor OS. The multivariate analysis showed that age, presence of surgery, and no hepatic or renal cysts were independent prognostic factors for OS. Chemotherapy achieved better outcomes, and HER2 mutations were not associated with HER2 amplification and overexpression.This study was novel in comprehensively investigating the clinical and molecular characteristics of patients in Chinese and Western populations, and in analyzing the factors affecting the prognosis of Chinese patients. It provided critical data for future therapies against HER2-altered NSCLC.
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- 2022
158. Ground state solutions for planar coupled system involving nonlinear Schrödinger equations with critical exponential growth
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Xiaoyan Lin, Jiuyang Wei, and Xianhua Tang
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symbols.namesake ,Nonlinear system ,Planar ,Exponential growth ,General Mathematics ,Mathematical analysis ,General Engineering ,symbols ,Ground state ,Schrödinger equation ,Mathematics - Published
- 2021
159. Phosphatidylethanolamine binding protein 1 enhances sensitivity of gastric cancer cell to 5-fluorouracil via inhibition of cell proliferation, migration and invasion
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Dongta Zhong, Xiaobing Huang, Qing Liu, Xinli Wang, Mengxin Lin, Ri-ping Wu, and Xiaoyan Lin
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education.field_of_study ,medicine.diagnostic_test ,Chemistry ,Cell growth ,Pharmaceutical Science ,Cell migration ,Flow cytometry ,Phosphatidylethanolamine binding protein 1 ,Downregulation and upregulation ,Apoptosis ,Cancer cell ,Cancer research ,medicine ,Pharmacology (medical) ,Viability assay ,education - Abstract
Purpose: To determine the association between phosphatidylethanolamine binding protein 1, which is an Raf kinase inhibitor protein (RKIP), and 5-fluorouracil (5-FU) via analysis of the association between RKIP and clinical responses in individuals treated using fluorouracil-based chemotherapy.Methods: Human gastric cancer cell lines MGC-803 and SGC-7901 were used in this study. Cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis and migration were determined with flow cytometry and Transwell chamber assays, respectively. The mRNA and protein expressions of apoptosis-related factors were assayed using realtime polymerase chain reaction (RT-PCR) and Western blotting, respectively, while the expression of RKIP was determined by immunohistochemical staining.Results: Chemotherapeutic drug (5-FU) treatment induced low RKIP expression levels in tumorigenic GC cells, thereby sensitizing the cells to apoptosis (8.57 vs 1.25 %, p < 0.01). The highest RKIP level correlated well with initiation of apoptosis (4.20 vs 1.25 %, p < 0.01). Following in vitro downregulation of RKIP, there was increase in the viability and proliferation of RKIP-inhibited cells over time, and these changes were linked to alterations in cell cycle phases and increased optical density in MTT proliferation assay (1.55 vs 1.18, p < 0.01). In vitro Transwell assay measurement revealed an association between RKIP downregulation and enhancement of cell migration potential (652 vs 436, p < 0.01). Ectopic RKIP expression restored the apoptotic sensitivity of resistant cells (14.30 vs 1.36 %, p
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- 2021
160. Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy
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Guanghui Gao, Zhe-Hai Wang, Jifeng Feng, Meijuan Huang, Xinmin Yu, Zhihua Liu, Caicun Zhou, Lihong Wu, Yina Wang, Ying Cheng, Jun Zhao, Yuan Chen, Zhiyong Ma, Weixia Li, Xiaoyan Lin, Shengxiang Ren, Kangsheng Gu, R. Guo, Jun Zhang, Quan Ren Wang, Xinfeng Yang, Gongyan Chen, Yu Yao, Jianxing He, Jianhua Chen, and Jianhua Shi
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Adult ,Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Adolescent ,Combination therapy ,Pyridines ,medicine.medical_treatment ,Population ,Antibodies, Monoclonal, Humanized ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Biomarkers, Tumor ,medicine ,Humans ,Apatinib ,education ,Adverse effect ,Survival rate ,Aged ,Retrospective Studies ,Chemotherapy ,education.field_of_study ,business.industry ,Middle Aged ,Prognosis ,Survival Rate ,Clinical trial ,030104 developmental biology ,chemistry ,Case-Control Studies ,030220 oncology & carcinogenesis ,Toxicity ,Female ,business ,Follow-Up Studies - Abstract
Purpose: Our preclinical work suggests that appropriate angiogenesis inhibition could potentiate PD-1/PD-L1 blockade via alleviating hypoxia, increasing infiltration of CD8+ T cells and reducing recruitment of tumor-associated macrophages. We hereby conducted a clinical trial to evaluate this combination in pretreated patients with advanced non–small cell lung cancer (NSCLC). Patients and Methods: The study included phase Ib apatinib dose-escalation and phase II expansion cohorts. Patients received apatinib at doses of 250–500 mg orally once daily, in combination with camrelizumab 200 mg intravenously every 2 weeks. Results: From March 2017 to October 2018, 105 chemotherapy-pretreated patients with nonsquamous NSCLC were enrolled and received apatinib 250 mg (recommended phase II dose) and camrelizumab. Among them, one (1.0%) complete response, 28 (26.7%) partial responses, and 48 (45.7%) stable diseases were observed. In the efficacy-evaluable population (n = 94), objective response rate (ORR) was 30.9% [95% confidence interval (CI), 21.7–41.2]. The median progression-free survival was 5.7 months (95% CI, 4.5–8.8) and overall survival was 15.5 months (95% CI, 10.9–24.5). Efficacy of combination therapy was evident across all PD-L1 and tumor mutation burden subgroups, and appeared to be improved in patients with STK11/KEAP1 mutation (mutant vs. wild-type, ORR: 42.9% vs. 28.1%; 1-year survival rate: 85.1% vs. 53.1%). No unexpected adverse events were observed. Conclusions: Combined apatinib and camrelizumab showed encouraging antitumor activity and acceptable toxicity in chemotherapy-pretreated patients with advanced nonsquamous NSCLC. Patients with STK11/KEAP1 mutation might derive more benefits from this combination. We will validate these results in an ongoing phase III trial (NCT04203485).
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- 2021
161. Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02)
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Ye Chen, Lin Shen, Shujun Yang, Xiao-Li Wei, Sheng Yao, Xichun Hu, Xianglin Yuan, Yi Jiang, Haixin Huang, Qi Li, Yongqian Shu, Rui-Hua Xu, Xiaoyan Lin, Guanghai Dai, Fenghua Wang, Qingyuan Zhang, Weifeng Wang, Hai Wu, Hui Feng, Yunpeng Liu, Jifeng Feng, Wangjun Liao, Jianhua Shi, and Nong Xu
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Adult ,Male ,0301 basic medicine ,Oncology ,China ,Herpesvirus 4, Human ,Cancer Research ,medicine.medical_specialty ,Time Factors ,Immune checkpoint inhibitors ,Programmed Cell Death 1 Receptor ,Antibodies, Monoclonal, Humanized ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Prospective Studies ,Progression-free survival ,Prospective cohort study ,Immune Checkpoint Inhibitors ,Aged ,Nasopharyngeal Carcinoma ,Proto-Oncogene Proteins c-ets ,business.industry ,Chromosomes, Human, Pair 11 ,Nasopharyngeal Neoplasms ,Middle Aged ,Viral Load ,medicine.disease ,Progression-Free Survival ,Repressor Proteins ,Clinical trial ,030104 developmental biology ,Nasopharyngeal carcinoma ,030220 oncology & carcinogenesis ,DNA, Viral ,Monoclonal ,Disease Progression ,Female ,Neoplasm Recurrence, Local ,Previously treated ,business ,Viral load - Abstract
PURPOSEAs yet, no checkpoint inhibitor has been approved to treat nasopharyngeal carcinoma (NPC). This study was aimed to evaluate the antitumor activity, safety, and biomarkers of toripalimab, a new programmed death-1 (PD-1) inhibitor for recurrent or metastatic NPC (RM-NPC) refractory to standard chemotherapy.PATIENTS AND METHODSIn this single-arm, multicenter phase II study, patients with RM-NPC received 3 mg/kg toripalimab once every 2 weeks via intravenous infusion until confirmed disease progression or unacceptable toxicity. The primary end point was objective response rate (ORR). The secondary end points included safety, duration of response (DOR), progression-free survival (PFS), and overall survival (OS).RESULTSAmong all 190 patients, the ORR was 20.5% with median DOR 12.8 months, median PFS 1.9 months, and median OS 17.4 months. Among 92 patients who failed at least two lines of systemic chemotherapy, the ORR was 23.9%. The ORRs were 27.1% and 19.4% in PD-L1+ and PD-L1− patients, respectively ( P = .31). Patients with ≥ 50% decrease of plasma Epstein-Barr virus (EBV) DNA copy number on day 28 had significantly better ORR than those with < 50% decrease, 48.3% versus 5.7% ( P = .0001). Tumor mutational burden had a median value of 0.95 muts/mega-base in the cohort and had no predictive value for response. Whole-exome sequencing results from 174 patients revealed that the patients with genomic amplification in 11q13 region or ETV6 genomic alterations had poor responses to toripalimab.CONCLUSIONThe POLARIS-02 study demonstrated a manageable safety profile and durable clinical response of toripalimab in patients with chemorefractory metastatic NPC. An early decrease in plasma EBV DNA copy number correlated with favorable response.
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- 2021
162. Adenosquamous carcinoma of the breast: a population-based study
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Zhangyuan Gu, Zhigang Zhuang, Cheng Wang, Xiaolin Cheng, Cheng Xu, Xiaoyan Lin, Jiejing Li, Yun Fu, and Juan Liu
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0301 basic medicine ,Oncology ,medicine.medical_treatment ,animal diseases ,0302 clinical medicine ,Surgical oncology ,Epidemiology ,Ductal ,Pharmacology (medical) ,Breast ,Mastectomy ,education.field_of_study ,Carcinoma, Ductal, Breast ,hemic and immune systems ,General Medicine ,Middle Aged ,Prognosis ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Original Article ,Female ,tissues ,medicine.medical_specialty ,endocrine system ,Adenosquamous carcinoma ,Population ,Breast Neoplasms ,03 medical and health sciences ,Adenosquamous ,Carcinoma, Adenosquamous ,Breast cancer ,Internal medicine ,medicine ,Carcinoma ,Humans ,Radiology, Nuclear Medicine and imaging ,education ,Aged ,Proportional Hazards Models ,Retrospective Studies ,business.industry ,Squamous cell ,medicine.disease ,eye diseases ,Radiation therapy ,Population based study ,030104 developmental biology ,business ,SEER Program - Abstract
Background To summarize the clinicopathological characteristics, prognosis, and management of breast adenosquamous carcinoma (ASC). Methods A population-based study was performed using retrospectively extracted data from the Surveillance, Epidemiology, and End Results database for breast cancer patients with histological diagnoses of ASC, infiltrating duct carcinoma (IDC) and squamous cell carcinoma (SCC) from 2004 to 2016. Results ASC presented similar tumor size but low histological grade and less lymph node metastasis compared to IDC. ASC expressed less positive rate of hormone receptors and barely HER2, which was similar with SCC. ASC patients underwent the similar surgical and systematic treatment as IDC, only with less radiotherapy. Median follow-up data of 78 months showed that the prognosis of IDC patients was better than that of ASC patients (all p 60) and advanced AJCC-stage were independent factors of poor prognosis in ASC, breast-conserving surgery was also ideally suited for ASC. Conclusions ASC has unique clinicopathological characteristics and prognosis. It is imperative to focus on a more precise and personalized treatment management of ASC patients.
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- 2021
163. Higher Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) Were Independently Associated with Increased Risks of Hypertension in Patients with T2DM: A Cross-Sectional Study
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Zhibin Li, Changqin Liu, Danyan Ma, Guobing Chen, Shuyu Yang, Xiaoyan Lin, Jinyang Zeng, Ziqing Xu, Fangfang Yan, and Weijuan Su
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medicine.medical_specialty ,Article Subject ,Cross-sectional study ,Type 2 diabetes ,Polysomnography ,030204 cardiovascular system & hematology ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Interquartile range ,Internal medicine ,Internal Medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,medicine.diagnostic_test ,business.industry ,Confounding ,Odds ratio ,medicine.disease ,nervous system diseases ,respiratory tract diseases ,030228 respiratory system ,Apnea–hypopnea index ,RC666-701 ,business ,Research Article - Abstract
Objective. The current study aimed to explore the relationship between OSAS and hypertension and whether polysomnography (PSG) indices were independently associated with hypertension in patients with type 2 diabetes (T2DM). Methods. This study recruited 316 T2DM patients. Multivariable logistic regression analyses were performed to determine the independent association of apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) with hypertension with adjustment for potential confounders. Results. Among 316 patients, 130 (41.1%) and 204 (64.6%) had hypertension and OSAS, respectively. T2DM patients with hypertension showed significantly increased levels of AHI ((median (interquartile range)): 17.2 (5.7–34.9) vs. 5.7 (2.1–17.3) events/hour, p p p p = 0.004). Multivariable logistic regression analysis showed that higher levels of AHI, NREM-AHI, and ODI were significantly associated with increased risks of hypertension, and the adjusted odds ratios (ORs) with 95% CI were 1.026 (1.008–1.044, p = 0.004), 1.026 (1.009–1.044, p = 0.003), and 1.005 (1.001–1.010, p = 0.040), respectively. Compared with non-OSAS, severe OSAS was significantly associated with the risk of hypertension with the adjusted OR (95% CI) of 3.626 (1.609–8.172, p = 0.002), but associations of rapid eye movement AHI (REM-AHI) and lowest SaO2 with hypertension were not statistically significant. Conclusion. Increased AHI, NREM-AHI, ODI, and severities of OSAS were significantly associated with higher risks of hypertension in T2DM patients. Detection and treatment of OSAS are needed to prevent hypertension in T2DM patients.
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- 2021
164. Preparation of high tensile strength modified cellulose-based strippable coating and its application on radioactive decontamination at low-temperature
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Xinrui Xu, Jian Li, Xunhai Pan, Xiaoyan Lin, and Zhanguo Li
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Mechanics of Materials ,Materials Chemistry ,General Materials Science - Published
- 2023
165. First-line (1L) nivolumab (NIVO) plus chemotherapy (chemo) vs chemo in patients (pts) with advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 Chinese subgroup analysis with 3-year follow-up
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Lin Shen, Yuxian Bai, Xiaoyan Lin, Wei Li, Jufeng Wang, Xiaochun Zhang, Hongming Pan, Chunmei Bai, Li Bai, Ying Cheng, Jingdong Zhang, Haijun Zhong, Yi Ba, Wenwei Hu, Rui-hua Xu, Weijian Guo, Shukui Qin, Rui Wang, Kendall Sullivan, and Tianshu Liu
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Cancer Research ,Oncology - Abstract
353 Background: NIVO + chemo demonstrated clinically meaningful improvement in overall survival (OS) and an acceptable safety profile vs chemo in previously untreated Chinese pts from CheckMate 649, consistent with the overall study population with advanced GC/GEJC/EAC. Results from CheckMate 649 led to approval of 1L NIVO + chemo in multiple countries, including China. We report 3-year follow-up results in Chinese pts. Methods: Adults with previously untreated, unresectable advanced or metastatic, non-HER2-positive GC/GEJC/EAC were enrolled regardless of programmed death ligand 1 (PD-L1) expression. Randomized pts received NIVO (360 mg Q3W or 240 mg Q2W) + chemo (XELOX Q3W or FOLFOX Q2W), NIVO + ipilimumab, or chemo. Dual primary endpoints for NIVO + chemo vs chemo were OS and progression-free survival (PFS) by blinded independent central review (BICR) in pts with PD-L1 combined positive score (CPS) ≥ 5. Results: 208 Chinese pts were randomized to NIVO + chemo or chemo. At 37 month (mo) minimum follow-up, NIVO + chemo continued to demonstrate clinically meaningful improvement in OS and PFS vs chemo in pts with PD-L1 CPS ≥ 5 and in all randomized pts. The 36-mo OS rate was 31% with NIVO + chemo vs 11% with chemo in pts with PD-L1 CPS ≥ 5 and 26% vs 9% in all randomized pts, respectively. Objective response rate (ORR) (95% CI) per BICR in pts with PD-L1 CPS ≥ 5 who had measurable lesions at baseline was 68% (56-79) with NIVO + chemo and 48% (36-60) with chemo, and in all randomized patients was 66% (55-76) and 45% (35-56), respectively. Responses were more durable with NIVO + chemo vs chemo in pts with PD-L1 CPS ≥ 5, with median duration of response (mDOR) (95% CI) of 12.5 mo (7.2-23.4) vs 6.9 mo (3.9-8.5); in all randomized pts, mDOR was 12.5 mo (7.2-17.7) vs 5.6 mo (4.4-8.3), respectively. No new safety signals were identified. Conclusions: After 3 years of follow-up, NIVO + chemo continued to demonstrate clinically meaningful survival benefit and durable objective responses vs chemo in Chinese pts, with an acceptable safety profile, consistent with the overall study population with advanced GC/GEJC/EAC. These results further support NIVO + chemo as a 1L treatment option for Chinese pts. Clinical trial information: NCT02872116 . [Table: see text]
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- 2023
166. TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage
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Philamer C. Calses, Victoria C. Pham, Alissa D. Guarnaccia, Meena Choi, Erik Verschueren, Sietske T. Bakker, Trang H. Pham, Trent Hinkle, Chad Liu, Matthew T. Chang, Noelyn Kljavin, Corey Bakalarski, Benjamin Haley, Jianing Zou, Cuicui Yan, Xia Song, Xiaoyan Lin, Rebecca Rowntree, Alan Ashworth, Anwesha Dey, and Jennie R. Lill
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Molecular Biology ,Biochemistry ,Analytical Chemistry - Published
- 2023
167. Bamboo pulp-based electret fiber aerogel with enhanced electret performance by P-phenylenediamine modification for simulated radioactive aerosol purification in confined spaces
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Chunxia Pang, Huanhuan You, Lili Liang, Zhanguo Li, Xiaoyan Lin, Yaping Zhang, Hao Zhang, Xunhai Pan, Yang Hu, Yan Chen, Xuegang Luo, and Haijun Wang
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Colloid and Surface Chemistry - Published
- 2023
168. Mild heat stress changes the microbiota diversity in the respiratory tract and the cecum of layer-type pullets
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Yunlei Zhou, H. C. Jiao, Xiaoyan Lin, Minghui Wang, Haifang Li, Hai Lin, Shuhong Sun, Jingpeng Zhao, V.A. Uyanga, and Xiaojuan Wang
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cecum microbiota ,Firmicutes ,T-Lymphocytes ,Respiratory System ,Cecum ,Animal science ,White blood cell ,medicine ,Microbiology and Food Safety ,Animals ,Relative humidity ,lcsh:SF1-1100 ,Brevibacillus ,biology ,Chemistry ,Microbiota ,Biodiversity ,General Medicine ,biology.organism_classification ,Blood Cell Count ,Red blood cell ,medicine.anatomical_structure ,mild heat stress ,respiratory microbiota ,Female ,Animal Science and Zoology ,lcsh:Animal culture ,layer-type pullet ,Hemoglobin ,Chickens ,Heat-Shock Response ,Respiratory tract - Abstract
The present study aimed to research the effects of cyclic heat environment on the microbial diversity and structure of respiratory tract and cecum of chicken. A total of 360 layer-type pullets at 11-weeks of age were subjected to different temperature treatments for 10 weeks: constant 22 °C; cyclic temperature 22-24 °C, 22-26 °C, 22-28 °C, 22-30 °C, the ambient temperature increased from 10:00, reached the set point within 1 h and maintained until 18:00, thereafter the temperature was restored to 22 °C, and the relative humidity was maintained at 60%. The result showed that feed intake of the chickens on ambient temperature 30 °C group was significantly lower than that of the chickens on ambient temperature 24 °C. The white blood cell (WBC), red blood cell (RBC), lymphocyte, hemoglobin (Hb) and pecked-cell volume (PCV) content were highest at 24 °C on 14, 16, 18 weeks. The ratio of CD3+CD4+ / CD3+CD8+ T cells was lowest at 30 °C. Meanwhile, the abundance of cecum bacteria in chickens at 30 °C was lower than that was at 24 °C. Cyclic heat environment temperature treatment did not significantly affect the concentration of SIgA in chicken bronchoalveolar lavage fluid (BALF) levels during 10 weeks of trial. The diversity index analysis showed that effect of 24 °C on the cecum flora of chickens was optimal. Abundance of Firmicutes bacteria in the lung flora and cecum flora was lower at 30 °C compared to 24 °C group. Similarly, the microorganism, Brevibacillus in the BALF was also significantly lower at 24 °C. In conclusion, cyclic 24 °C treatment was beneficial for the feed intake, blood routine indexes, microflora structure of the cecum and respiratory tract in laying pullets.
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- 2020
169. Identification of Immune-Related Prognostic Biomarkers in Pancreatic Cancer
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Jiakang Ma, Mingyu Hou, Kaikai Ren, Ling Yuan, Bo Zhou, Ling Zhang, Yong Shen, Xiaoyan Lin, and Jun Ma
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Immune system ,business.industry ,animal diseases ,Pancreatic cancer ,medicine ,Cancer research ,bacteria ,chemical and pharmacologic phenomena ,General Materials Science ,Identification (biology) ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,business - Abstract
Immunotherapy for pancreatic cancer (PC) faces significant challenges. It is urgent to find immunerelated genes for targeted therapy. We aimed to identify immune-related messenger ribonucleic acids (mRNAs) with multiple methods of comprehensive immunoenrichment analysis in predicting survival of PC. PC genomics and clinical data were downloaded from TCGA. We analyzed relative enrichment of 29 immune cells using ssGSEA and classified PC samples into three immuneinfiltrating subgroups. Immune cell infiltration level and pathways were evaluated by ESTIMATE data and KEGG. Independent risk factors were derived from the combined analysis of WGCNA, LASSO regression and Cox regression analyses. Immune risk score was calculated according to four mRNAs to identify its value in predicting survival. PPI analysis was used to analyze the connections and potential pathways among genes. Finally, PC samples were classified into three immuneinfiltrating subgroups. Immunity high subgroup had higher immune score, soakage of immune cells, HLA/PD-L1 expression level, immune-related pathways enrichment and better survivability. Four potential prognostic immune-related genes (ITGB7, RAC2, DNASE1L3, and TRAF1) were identified. Immune risk score could be a potential survival prediction indictor with high sensitivity and specificity (AUC values = 0.708, HR = 1.445). A PPI network with seven nodes and five potential targeted pathways were generated. In conclusion, we estimated the state of immune infiltration in the PC tumor microenvironment by calculating stromal and immune cells enrichment with ssGSEA algorithms, and identified four prognostic immune-related genes that affect the proportion and distribution of immune cells infiltration in the tumor microenvironment. They lay a theoretical foundation to be important immunity targets of individual treatment in PC.
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- 2020
170. Molecular-solution printing of Cu2ZnSnS4 (CZTS) thin film
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Jin Chen, Qinmiao Chen, Xiaoming Dou, Xiaoyan Lin, Canyun Zhang, Fengchao Wang, and Bobo Yang
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Fabrication ,Materials science ,Band gap ,Annealing (metallurgy) ,Nanoparticle ,02 engineering and technology ,engineering.material ,01 natural sciences ,chemistry.chemical_compound ,0103 physical sciences ,Materials Chemistry ,Kesterite ,CZTS ,Rapid thermal annealing ,Thin film ,010302 applied physics ,business.industry ,Process Chemistry and Technology ,021001 nanoscience & nanotechnology ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Ceramics and Composites ,engineering ,Optoelectronics ,0210 nano-technology ,business - Abstract
In this work, a novel molecular-solution printing approach combined with a rapid thermal annealing process for the facile fabrication of Cu2ZnSnS4 (CZTS) thin film is reported. The intrinsic relationship between annealing parameters (temperature and time) and the properties of the fabricated samples was investigated systematically. Furthermore, the mechanism behind this CZTS formation approach was studied in detail. The results show that the best properties were obtained for the sample annealed at 600 °C for 45 min, which displayed a pure kesterite CZTS phase, acceptable morphology consisting of 1.0–1.5 μm size nanoparticles, a satisfactory Cu-poor and Zn-rich composition, and an ideal bandgap of ~1.42 eV. Thus, the prepared sample is a promising candidate for the fabrication of high-performance photovoltaic devices.
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- 2020
171. On the Klein‐Gordon‐Maxwell system with critical exponential growth in ℝ2
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Xianhua Tang, Xiaoyan Lin, and Sitong Chen
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symbols.namesake ,Exponential growth ,General Mathematics ,General Engineering ,symbols ,Klein–Gordon equation ,Mathematical physics ,Mathematics - Published
- 2020
172. Microwave-assisted hydrothermal synthesis of carbon doped with phosphorus for uranium(VI) adsorption
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Lan Liu, Meijuan Liu, Hongyi Wang, Hongying Gong, Jian Zhou, Zhichen Du, Lili Liang, Xiaoyan Lin, Xuegang Luo, Zhanguo Li, Huanhuan Chu, Yu Xie, and Mengsha Li
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Phytic acid ,Health, Toxicology and Mutagenesis ,Phosphorus ,Public Health, Environmental and Occupational Health ,chemistry.chemical_element ,Uranium ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Pollution ,Hydrothermal circulation ,0104 chemical sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Adsorption ,Nuclear Energy and Engineering ,chemistry ,Selective adsorption ,Hydrothermal synthesis ,Radiology, Nuclear Medicine and imaging ,Carbon ,Spectroscopy ,Nuclear chemistry - Abstract
In this study, hydrothermal carbon doped with phosphorus using phytic acid (PA) and Sodium tripolyphosphate as functional monomers was successfully synthesized by the hydrothermal route combined with microwave-assisted hydrothermal carbon as matrix material. The uranium(VI) adsorption capacity by phytic acid functionalized microwave-assisted hydrothermal carbon (MHC-PA) was up to 382.2 mg/g at pH of 6.0 and the temperature of 298.15 K. The adsorption mechanism of uranium(VI) onto the MHC-PA was mainly the chelation of P=O, P–OH functional group and uranium(VI), which improves the selective adsorption performance of MHC-PA for uranium(VI).
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- 2020
173. The effect of low-dose chemotherapy on the tumor microenvironment and its antitumor activity combined with anti-PD-1 antibody
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Fangyu Lin, Hao Chen, Tao Jiang, Jianwei Zheng, Qin Liu, Baoyu Yang, Xinli Wang, and Xiaoyan Lin
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Oncology ,Immunology ,Immunology and Allergy ,sense organs - Abstract
Aim: This study aimed to explore the effects of low-dose chemotherapy in the tumor microenvironment (TME) on a gastric cancer xenograft and its antitumor activity combined with the anti-PD-1 antibody. Materials & methods: Mice with gastric cancer were divided into four groups. The body weight and tumor volume of the mice were recorded. The TME was analyzed using flow cytometry. Results: Low-dose paclitaxel increased the PD-L1 expression level and the number of CD8+ T cells, but not the CD4+ T and myeloid-derived suppressor cells or PD-1+ CD8+ T cells in the TME. Low-dose 5-fluorouracil reduced the number of myeloid-derived suppressor cells and PD-1+ CD8+ T cells, but the PD-L1 expression level and the number of CD4+ T and CD8+ T cells did not change in the TME. The anti-PD-1 antibody inhibited tumor growth, but the combination therapy did not show superior antitumor activity. Conclusion: Low-dose chemotherapy altered the TME but failed to improve the responses to the anti-PD-1 antibody.
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- 2022
174. CLEC10A can serve as a potential therapeutic target and its level correlates with immune infiltration in breast cancer
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Shasha Tang, Yi Zhang, Xiaoyan Lin, Hui Wang, Liyun Yong, Hongyi Zhang, and Fengfeng Cai
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Cancer Research ,Oncology - Abstract
Breast cancer (BC) is one of the most common malignant cancers in females worldwide and greatly threatens women's health. The C-type lectin domain family 10 member A (CLEC10A) is a member of the C-type lectin receptor family that has been previously reported to promote the antitumor activity of immune cells. In the present study, the potential prognostic value of CLEC10A expression in BC was assessed using data from The Cancer Genome Atlas online database. Differences in the mRNA expression levels of CLEC10A between BC and normal tissues were then analyzed using the Tumor Immune Estimation Resource (TIMER) platform and the University of Alabama at Birmingham Cancer data analysis portal. Reverse transcription-quantitative PCR was performed to validate the results of this analysis. The Kaplan-Meier plotter database was used to evaluate the association between the mRNA expression levels of CLEC10A and clinical prognosis of BC. Based on the association between the mRNA expression levels of CLEC10A and the tumor immune microenvironment, the TIMER platform and the Tumor and Immune System Interaction Database website were utilized to assess the correlation between CLEC10A expression and the degree of tumor immune cell infiltration. The present study revealed that CLEC10A expression was significantly lower in BC tissues compared with that in normal tissues, which was in turn associated with poorer clinical outcomes. This suggested that lower CLEC10A expression levels were associated with unfavorable prognosis in BC. In addition, the expression level of CLEC10A was found to be positively associated with the level of different tumor-infiltrating immune cells in BC, including CD8 T cells, B cells, macrophages and NK cells which, was in turn closely correlated with some gene markers such as CD19, CD8A, KIR2DS4 and PTGS2. These results suggest that the relationship between lower CLEC10A expression level and poor prognosis in BC may be due to the role of CLEC10A in the tumor immune microenvironment. In conclusion, CLEC10A may be a potential biomarker that can be used to efficiently predict prognosis in patients with BC.
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- 2022
175. A pyroptosis-related prognosis model to predict survival in colorectal cancer patients
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Meiyan, Chen, Jingyi, Zhang, Xiaoyan, Lin, Xiaosan, Zhu, and Tao, Xie
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Original Article - Abstract
Pyroptosis is a recently-identified pathway of host cell death that is stimulated by a range of microbial infections. Emerging evidence indicates pyroptosis plays crucial roles in tumor growth, disease progression, and migration of different cancer cells. However, the clinical significance of pyroptosis in tumor behavior prognosis, as well as the underlying mechanism in different cancers remains elusive. Here, by evaluating the expression level of pyroptosis genes in colorectal cancer (CRC) patients from the TCGA cohort and GEO cohort (GSE39582), we identified pyroptosis-related DEGs and then built a 13-gene risk model by applying the LASSO Cox regression algorithm. Furthermore, functional analysis using GSEA and GSEV revealed that our prognostic model may function through regulating immune responses and tumor biogenesis pathways. Significant infiltration of activated immune cells (e.g. cytotoxic T cells) was observed in the low risk score group. The selected gene set was further validated in the GEO cohort. Time-dependent ROC curves confirmed that our risk score model is robust in predicting 1, 3 and 5-year overall survival in CRC patients. Overall, we have identified a pyroptosis-related gene signature that consists of 13 genes, which serves as a potent indicator of CRC prognosis. Thus, our model provides insights in how to make better clinical decision in the future.
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- 2022
176. A Selective Fluorescent Probe for the Determination and Imaging of Fluoride in Living Cells
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Xuejun Cui, Xingong Wang, Xiaoyan Lin, and Yanchao Liang
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Fluorescent probe ,Fluoride determination ,Macrophages ,Fluorescence image ,Indispensable trace element - Abstract
Fluoride anions are indispensable trace elements required for sustaining life. To investigate the homeostasis and action of fluoride in the body, a new highly sensitive and selective fluorescence detection method was designed for fluoride in aqueous solutions. A fluorescent probe for fluoride (FP-F) was synthesized for imaging F- in living cells. The design strategy for the probe was based on the specific reaction between fluoride and silica to mediate deprotection of this probe to fluorescein. Upon treatment with F-, FP-F, a closed and weakly fluorescent lactone, was transformed into an open and strongly fluorescent product. Under the optimum conditions, the detection limit for fluoride was 0.526 nM. FP-F could detect micromolar changes in F- concentrations in living cells by confocal microscopy.
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- 2022
177. Bayesian Proportional Odds Models for Analyzing Current Status Data: Univariate, Clustered, and Multivariate.
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Xiaoyan Lin and Lianming Wang
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- 2011
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178. Bayesian proportional hazards model for current status data with monotone splines.
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Bo Cai, Xiaoyan Lin, and Lianming Wang
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- 2011
- Full Text
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179. Baicalin regulates Treg/Th17 cell imbalance by inhibiting autophagy in allergic rhinitis
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Jing Li, Xiaoyan Lin, Xiang Liu, Zhiqi Ma, and Yong Li
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0301 basic medicine ,Immunology ,Mucous membrane of nose ,T-Lymphocytes, Regulatory ,Peripheral blood mononuclear cell ,Flow cytometry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Autophagy ,medicine ,Animals ,Humans ,Molecular Biology ,Flavonoids ,Eosinophil cationic protein ,biology ,medicine.diagnostic_test ,Chemistry ,Anti-Inflammatory Agents, Non-Steroidal ,Eosinophil ,Rhinitis, Allergic ,Molecular biology ,Ovalbumin ,030104 developmental biology ,medicine.anatomical_structure ,biology.protein ,Th17 Cells ,Baicalin ,030215 immunology - Abstract
Background Baicalin has many biological properties such as anti-oxidation and anti-allergy. The current study aimed to explore the effect of Baicalin on allergic rhinitis (AR) and its potential mechanism of action. Methods Peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation. Expression levels of Th17 and Treg cells-related proteins in nasal mucosa and peripheral blood cells were detected by real-time quantitative PCR, flow cytometry and Western blot. The mice were randomly divided into Control, ovalbumin (OVA), l -Baicalin, H-Baicalin, DSGC, 3-MA, and H-Baicalin + Rapa groups. Changes of allergic rhinitis conditions and eosinophil infiltration of the mice were detected and scored by Diff-Quik staining, and histological changes were observed by Hematoxylin & Eosin (H&E) staining and Periodate Schiff (PAS) staining. Serological changes, expression levels of interleukin-17A (IL-17A), interleukin-10 (IL-10), eosinophilic cationic protein (ECP) and anti-OVA-specific antibodies were detected by Enzyme-linked immunosorbent assay (ELISA). Results Clinical case analysis found that AR patients had a Th17/Treg imbalance and activated autophagy, however, Baicalin restored Th17/Treg cell balance and inhibited autophagy in vitro. in vivo experiments demonstrated that Baicalin inhibited OVA-induced allergic nasal symptoms and the activation of autophagy pathway, which was the same as the regulation of 3-MA, while Rapa could weaken the effects of H-baicalin. Moreover, Baicalin reduced the infiltration of different inflammatory cells of the nasal lavage fluid, prevented the damages to epithelial cells, and improved nasal mucosal thickness and mucus secretion. In addition, Baicalin regulated the balance of mouse anti-OVA-specific antibody levels and expressions of Th17/Treg-associated cytokines. Conclusion Our study revealed that Baicalin can be used to treat AR, and the effect is realized through inhibiting autophagy to regulate Th17/Treg cell differentiation.
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- 2020
180. The Effect of Immune-Related Genes on Colonic Adenocarcinoma Prognosis
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Jiakang Ma, Xiaoyan Lin, Mingyu Hou, and Jun Ma
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business.industry ,Cancer research ,Medicine ,General Materials Science ,Colonic adenocarcinoma ,business ,Immune related genes - Abstract
Colorectal adenocarcinoma (COAD) is the most common type of colon cancer, and its occurrence is intimately associated with immune-related gene (IRG) expression. In this research, the IRG expression was analyzed and 484 were found significantly different between COAD and normal tissue. To construct a COAD patient IRGs-prognosis model, 11 of the IRGs were selected by multivariate Cox analysis. IRGs in the model were closely related to tumor invasion depth, lymphoid involvement, distant metastasis, stage, and age. This work lays the foundation for future scientific research and clinical work related to COAD.
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- 2020
181. Effects of a Mind Map–Based Life Review Program on Anxiety and Depressive Symptoms on Cancer Patients Undergoing Chemotherapy
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Xiaoyan Lin, Jianwei Zheng, Xiaoling Zhang, Ying Chen, and Huimin Xiao
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medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Anxiety ,law.invention ,Randomized controlled trial ,Behavior Therapy ,law ,Neoplasms ,Internal medicine ,Humans ,Medicine ,Depressive symptoms ,Chemotherapy ,Depression ,Oncology (nursing) ,business.industry ,Repeated measures design ,Cancer ,medicine.disease ,Anxiety Disorders ,Oncology ,Quality of Life ,medicine.symptom ,business ,Life review - Abstract
BACKGROUND Cancer patients undergoing chemotherapy often experience psychological distress. The mind map-based life review program (MBLRP) offers the potential to reduce patients' negative emotions. However, its effects remain unknown. OBJECTIVE The objective of this study is to determine the effects of the MBLRP on anxiety and depressive symptoms in cancer patients undergoing chemotherapy. METHODS A randomized controlled trial with repeated measures was adopted. Eighty-four cancer patients undergoing chemotherapy were recruited from a general hospital in Fujian, China. Participants were randomly assigned to an experimental group (n = 40) or a control group (n = 44). The participants in the experimental group received the MBLRP plus routine care. The participants in the control group received routine care. Outcomes were measured at baseline, on the second day, and at 4 weeks after the MBLRP. RESULTS In terms of anxiety, multivariate test statistics showed significant differences in within-group (F = 11.343, P < .001), between-group (F = 8.873, P = .004), and interaction effects (group × time) (F = 19.595, P < .001). For the depressive symptoms, the results showed that the within-group effect (F = 12.385, P < .001), group effect (F = 18.000, P < .001), and group × time effect (F = 26.544, P < .001) were statistically significant, favoring the MBLRP experimental group. CONCLUSIONS The MBLRP has the potential to reduce anxiety and depressive symptoms in cancer patients undergoing chemotherapy. Further research is needed within larger more representative samples. IMPLICATIONS FOR PRACTICE The MBLRP is a nurse-led, nonpharmacological program that could be recommended for cancer patients undergoing chemotherapy and integrated into clinical practice.
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- 2020
182. Monetary Policy and Housing Prices: Expansion of the Fictitious Economy in China
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Xiaoyan Lin, Peng Wang, and Yan Li
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Economics and Econometrics ,General Social Sciences ,Business and International Management - Published
- 2020
183. Identification of prognostic and immune-related lncRNAs in hepatocellular carcinoma based on the cancer genome atlas data mining
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Jiakang Ma, Xiaoyan Lin, Ling Yuan, Mingyu Hou, Jun Ma, Bo Zhou, Ling Zhang, and Kaikai Ren
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Materials science ,Immune system ,Hepatocellular carcinoma ,Cancer genome ,Atlas data ,medicine ,General Materials Science ,Identification (biology) ,Computational biology ,medicine.disease ,digestive system diseases - Abstract
Hepatocellular carcinoma (HCC) is a malignancy originating from hepatocytes with a high rate of distant metastasis and recurrence. HCC prognosis remains poorly understood, although its diagnosis and treatment have improved globally. Therefore, it is necessary to identify reliable predictive and prognostic indicators of HCC. HCC gene expression profiles and corresponding clinical data were downloaded from The Cancer Genome Atlas. Seven lncRNAs (C10orf91, AC011352.3, AC015722.2, AC006372.1, PICSAR, AC110285.3, and AP001972.4) associated with immune and clinicopathological features were identified as biomarker candidates for HCC prognosis based on single-sample gene set enrichment analysis, the ESTIMATE algorithm, and Cox PHR analyses. Altogether, the findings revealed that the seven immune-related lncRNAs may provide a reference for improving HCC prognosis.
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- 2020
184. Recent Advances in Triarylmethane Synthesis
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Xue Liu, Xiaoyan Lin, Ling Zhang, Xiangmei Wu, and Dayun Huang
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chemistry.chemical_classification ,010405 organic chemistry ,Organic Chemistry ,Halide ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Sulfonamide ,chemistry.chemical_compound ,chemistry ,Reagent ,Molecule ,Organic chemistry ,Ammonium ,Methylene - Abstract
Triarylmethanes are important molecules in organic chemistry. This review discusses advances in their synthesis summarized in five categories according to the starting materials: (1) benzyl reagents with different leaving groups, such as benzyl alcohols, ethers, esters, phosphates, sulfones, thioethers, sulfonamide, 1,3-dicarbonyls, and ammonium salts; (2) reactions via para- or ortho-quinone methides; (3) arylation of benzyl halides; (4) C–H activation of methylenes; and (5) reactions of aldehydes or N-tosylhydrazones. Triarylmethane derivatives such as 9-arylxanthenones, 9-arylfluorenes, and aryloxepines are also discussed.1 Introduction2 Benzyl Reagents with Leaving Groups3 Quinone Methide Mediated Reactions4 Arylation of Benzyl Halides5 C–H Activation of Methylene6 Reactions of Carbonyl Compounds7 Conclusions
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- 2020
185. Cetuximab Maintenance Therapy in Patients with Unresectable Wild-Type RAS and BRAF Metastatic Colorectal Cancer: A Single-Institute Prospective Study
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Xinli Wang, Mengxin Lin, Qing Liu, Hao Chen, Baoyu Yang, Jinhuo Lai, Dongta Zhong, Tao Jiang, Jianwei Zheng, Peifeng Hou, Bin Du, Xiaoyan Lin, and Han Wang
- Subjects
Adult ,Male ,Proto-Oncogene Proteins B-raf ,Oncology ,medicine.medical_specialty ,Adolescent ,Colorectal cancer ,Leucovorin ,Cetuximab ,Irinotecan ,Maintenance Chemotherapy ,Young Adult ,Maintenance therapy ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Mucositis ,Humans ,Pharmacology (medical) ,Prospective Studies ,Neoplasm Metastasis ,Aged ,business.industry ,Hazard ratio ,General Medicine ,Middle Aged ,medicine.disease ,Progression-Free Survival ,digestive system diseases ,Fluorouracil ,FOLFIRI ,Female ,Colorectal Neoplasms ,business ,medicine.drug - Abstract
Cetuximab plus FOLFIRI (leucovorin, fluorouracil, and irinotecan) is the preferred first-line therapy for RAS and BRAF wild-type (RBWT) metastatic colorectal cancer (mCRC). To counter chemotherapy-induced side effects, use of maintenance therapy is suggested. Therefore, we evaluated the efficacy and safety of cetuximab maintenance therapy in patients after effective completion of first-line induction therapy. This prospective study enrolled untreated patients with mCRC RBWT who received first-line cetuximab plus FOLFIRI therapy. Following this, patients with treatment response either entered observation (stop treatment) or maintenance treatment 1 (cetuximab plus irinotecan) groups. After 6–12 cycles of maintenance treatment 1, patients entered maintenance treatment 2 (cetuximab only). If a patient progressed on maintenance 2, cetuximab plus FOLFIRI was reintroduced. The primary end point was failure-free survival (FFS), whereas the secondary end points included disease control rate (DCR), objective remission rate (ORR), and progression-free survival (PFS). Safety events were also evaluated. Among 79 enrolled patients, 72 completed first-line treatment effectively (DCR 91.1%, ORR 63.9%) and 44 entered maintenance 1 [median PFS 1 (mPFS, maintenance 1) 6.1 months, 95% confidence interval (CI) 6.0–6.2; DCR 56.8%; ORR 22.7%]. Of them, 21 entered maintenance treatment 2 (mPFS2 8.7 months, 95% CI 3.3–14.1; DCR 28.6%; ORR 4.8%). Median FFS (mFFS) was significantly longer in the maintenance 1 group compared with the observation group [12.7 vs. 3.0 months; hazard ratio (HR) 0.202, 95% CI 0.111–0.369; P
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- 2020
186. A measurement method of knee joint space width by ultrasound: a large multicenter study
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Shuqiang Chen, Jianying Mao, Yuanjiao Tang, Yuanyi Zheng, Shaoyun Hao, Ning Lin, Hongmei Liu, Jian Chen, Yue Hu, Xiaojing Peng, Yong Shan, Shiliang Xu, Tao Chen, Yuanyuan Zhang, Bo Bao, Siming Chen, Xing Hua, Xiuzhen He, Yuexiang Wang, Guoqing Du, Jiaan Zhu, Baoming Luo, Li-Gang Cui, Ping Wang, Dan Jiao, Zhanguo Xi, Ting Dai, Zhenlong Hu, Xueling Liu, Shumin Zhang, Qunxia Zhang, Bing Li, Mingdi Fang, Jia Li, Li Qiu, Weiyong Liu, Mi Zhang, Bin Tu, Yanni He, Minghui Xiang, and Xiaoyan Lin
- Subjects
musculoskeletal diseases ,030203 arthritis & rheumatology ,0301 basic medicine ,Orthodontics ,Measurement method ,business.industry ,Ultrasound ,Statistical difference ,Knee Joint ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Multicenter study ,Medicine ,Original Article ,Radiology, Nuclear Medicine and imaging ,Tibia ,Epicondyle ,business ,Medial knee - Abstract
Background Although plain radiology is the primary method for assessing joint space width (JSW), it has poor sensitivity to change over time in regards to determining longitudinal progression. We, therefore, developed a new ultrasound (US) measurement method of knee JSW and aimed to provide a monitoring method for the change of JSW in the future. Methods A multicenter study was promoted by the Professional Committee of Musculoskeletal Ultrasound, the Ultrasound Society, and the Chinese Medical Doctor Association. US study of knee specimens determined the landmarks for ultrasonic measurement of knee JSW. The US of 1,272 participants from 27 centers was performed to discuss the feasibility and possible influencing factors of knee JSW. The landmarks for US measurement of knee JS, the inflection point of medial femoral epicondyle and the proximal end of the tibia, were determined. Results The mean knee JSW1 (medial knee JSW) was 8.57±1.95 mm in females and 9.52±2.31 mm in males. The mean knee JSW2 (the near medial knee JSW) was 9.07±2.24 mm in females and 10.17±2.35 mm in males. The JSW values of males were significantly higher than those of females, with a statistical difference. JSW values were negatively correlated with age and body mass index (BMI) to different degrees and positively correlated with height. Conclusions The novel US measurement method can be used to measure knee JSW.
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- 2020
187. Theoretical Simulation of X-Ray Transmission Through a Polycapillary X-Ray Lens With a Variable Capillary Radius
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Heng Luo, Lei Ye, Xingyi Wang, Xiaoyan Lin, Xin Liu, Jiayu Duan, Yude Li, and Mo Zhou
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Nuclear and High Energy Physics ,Materials science ,010308 nuclear & particles physics ,Capillary action ,business.industry ,Astrophysics::High Energy Astrophysical Phenomena ,X-ray ,01 natural sciences ,law.invention ,Capillary radius ,Physics::Fluid Dynamics ,Lens (optics) ,Reflection (mathematics) ,Optics ,Nuclear Energy and Engineering ,Transmission (telecommunications) ,law ,0103 physical sciences ,Electrical and Electronic Engineering ,business ,Layer (electronics) ,Intensity (heat transfer) - Abstract
This article presents a model for simulating the X-ray transmission properties of a polycapillary X-ray lens in which the capillaries are arranged in a layered hexagonal structure. Each layer consists of hexagonally shaped capillary bundles which are arranged symmetrically around a centerline, and the capillary radius varies with the layer. The transmission efficiency of X-rays in different layers is studied, and by designing the capillary radius, a uniform X-ray intensity distribution is generated at the output of the polycapillary parallel X-ray lens, which has remarkable differences with the distribution of a conventional polycapillary parallel X-ray lens. In addition, several common defects in the manufacturing process of the polycapillary lens are simulated.
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- 2020
188. Ground state solutions of Nehari-Pankov type for Schrödinger equations with local super-quadratic conditions
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Sitong Chen, Xiaoyan Lin, Jianshe Yu, and Xianhua Tang
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Asymptotically linear ,Pure mathematics ,Applied Mathematics ,010102 general mathematics ,Type (model theory) ,01 natural sciences ,Schrödinger equation ,010101 applied mathematics ,symbols.namesake ,Quadratic equation ,Domain (ring theory) ,symbols ,Spectral gap ,0101 mathematics ,Ground state ,Analysis ,Mathematics - Abstract
Consider the semilinear Schrodinger equation { − △ u + V ( x ) u = f ( x , u ) , x ∈ R N , u ∈ H 1 ( R N ) , where both V ( x ) and f ( x , u ) are periodic in x, 0 belongs to a spectral gap of − △ + V , and f ( x , u ) is subcritical and allowed to be super-linear at some x ∈ R N and asymptotically linear at the other x ∈ R N . In the existing works in the literature, it is commonly assumed that lim | u | → ∞ ∫ 0 u f ( x , s ) d s u 2 = ∞ uniformly in x ∈ R N , to obtain the existence of ground state solutions or infinitely many geometrically distinct solutions. In this paper, for the first time, we prove the existence of ground state solutions and infinitely many geometrically distinct solutions under the weaker super-quadratic condition lim | u | → ∞ ∫ 0 u f ( x , s ) d s u 2 = ∞ , a.e. x ∈ G just for some domain G ⊂ R N .
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- 2020
189. METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway
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Juan Li, Shu-Mei Liang, Feng Geng, Hongwei Guan, Na Li, and Xiaoyan Lin
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0301 basic medicine ,Cancer Research ,endocrine system diseases ,Biology ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,oncogene ,medicine ,Protein kinase B ,Gene knockdown ,Oncogene ,Akt/PKB signaling pathway ,AKT ,apoptosis ,Cancer ,Articles ,Cell cycle ,medicine.disease ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,METTL3 ,mitochondria pathway ,Carcinogenesis ,Ovarian cancer - Abstract
Methyltransferase-like 3 (METTL3) has been identified as a methyltransferase responsible for N6-methyla-denosine (m6A) modification of mRNA. METTL3 functions in tumorigenesis and tumor development by promoting the translation of oncoproteins; however, the role of METTL3 in ovarian cancer has not been extensively studied. The present study performed immunohistochemistry to detect METTL3 expression levels in 52 samples of ovarian cancer tissue paired with corresponding paracancerous tissue. RNA interference was conducted to downregulate the expression levels of METTL3 in the SKOV3 and OVCAR3 ovarian cancer cell lines. Reverse transcription-quantitative PCR and western blot analysis demonstrated the effects of METTL3 knockdown on mRNA and protein levels, respectively. CCK-8, colony formation, apoptosis and Transwell assays were also performed. The results demonstrated that METTL3 exhibited significantly higher expression levels in ovarian cancer tissues compared with corresponding paracancerous tissue. High METTL3 expression levels were associated with large tumors, lymph node metastasis and high pathological grade. Cell proliferation analysis revealed that METTL3 knockdown reduced the proliferation and clonogenic ability of SKOV3 and OVCAR3 cells. Apoptotic rates were increased in METTL3-silenced ovarian cancer cells, which may have been mediated by the activation of the mitochondrial apoptosis pathway, and METTL3 knockdown reduced cell invasion. METTL3 knockdown downregulated the phosphorylation levels of AKT and the expression of the downstream effector Cyclin D1. These results suggested that METTL3 may serve an oncogenic function in the progression of human ovarian cancer cells partially through the AKT signaling pathway, indicating that METTL3 may be a potentially novel therapeutic target for the treatment of ovarian cancer.
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- 2020
190. Depth-sensitive analysis of metals to investigate the corrosion process in oil pipelines by confocal 3D-XRF and SEM-EDS
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Tianxi Sun, Meng Zhaoying, Xiang Zhujun, Xingyi Wang, Peng Zhou, Xiaoyan Lin, Xinran Ma, Yude Li, and Zhiguo Liu
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Nuclear and High Energy Physics ,Materials science ,Spectrometer ,Scanning electron microscope ,Confocal ,010401 analytical chemistry ,Metallurgy ,chemistry.chemical_element ,02 engineering and technology ,Zinc ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Corrosion ,Pipeline transport ,chemistry ,0210 nano-technology ,Spectroscopy ,Instrumentation ,Titanium - Abstract
Two paint fragments from an oil pipeline were analyzed with a confocal three-dimensional micro-X-ray fluorescence (3D-XRF) spectrometer. The depth distributions of iron (Fe), titanium (Ti) and zinc (Zn) metal elements were obtained based on confocal 3D-XRF analysis. The quantitative element results were obtained by scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS). The corrosion process of the oil pipeline was investigated based on the experimental results, which provided information for designing an oil pipeline protection scheme.
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- 2020
191. High frequency vaccination-induced immune stress reduces bone strength with the involvement of activated osteoclastogenesis in layer pullets
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Xiaoyan Lin, Hongchao Jiao, Mengze Song, Jingpeng Zhao, Shuhong Sun, Haifang Li, Hai Lin, and Xiaojuan Wang
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musculoskeletal diseases ,medicine.medical_specialty ,Spleen ,layer pullets ,OPG/RANKL ,Avian Proteins ,03 medical and health sciences ,Immune system ,Osteoprotegerin ,Osteogenesis ,Stress, Physiological ,Internal medicine ,Animals ,Medicine ,Tibia ,Receptor ,lcsh:SF1-1100 ,030304 developmental biology ,0303 health sciences ,Bone Development ,immune stress ,biology ,business.industry ,Vaccination ,0402 animal and dairy science ,Antibody titer ,04 agricultural and veterinary sciences ,General Medicine ,Immunology, Health and Disease ,040201 dairy & animal science ,Specific Pathogen-Free Organisms ,Endocrinology ,medicine.anatomical_structure ,RANKL ,Immune System ,biology.protein ,Cytokines ,Female ,Animal Science and Zoology ,lcsh:Animal culture ,business ,Chickens ,Signal Transduction - Abstract
In poultry production, vaccination is an effective measure to protect chickens from diseases. Vaccination, however, is a stressor that may induce stress responses that interfere with the growth and development of chickens. The interaction between the skeletal and immune systems on bone quality has gained more attention. In the present study, the influence of high frequency vaccinations on the bone development of layer pullets was investigated. Thirty 35-day-old SPF White Leghorn layer pullets were obtained and randomly subjected to the following treatments: vaccinated against Newcastle disease (ND) with LoSota vaccine once at 35-day-old (V1, control); 4 times at 35, 49, 63, and 77 d of age (V4); and 7 times at 35, 42, 49, 56, 63, 70, and 77 d of age (V7). The body weight and organ index of the spleen, thymus, and tibia were recorded. The antibody titer and serum and the tibia calcium and phosphorus concentrations were measured. The transcription levels of the IL-6, IL-17, TNF-α, receptor activator of NF-κB ligand (RANKL), and osteoprotegerin (OPG) genes were determined in spleen, thymus, and the tibia. The results showed that V7 decreased body weight and increased the ND antibody titer, compared to V1-chickens. The expression levels of IL-6, IL-17, and TNF-α were upregulated in spleen, thymus, and the tibia of V7 chickens. In the tibia, RANKL was upregulated, while OPG was downregulated by V7 treatment. The results indicate that high frequency vaccination induces immune stress and impairs bone development. The results suggest that the augmented cytokine expression in immune organs and the tibia is associated with activation of the OPG/RANKL pathway, which, in turn, enhances osteoclastogenesis. The appropriate frequency of vaccination should support optimal bone development and full immunoprotection in layer pullets.
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- 2020
192. FAM83D promotes epithelial-mesenchymal transition, invasion and cisplatin resistance through regulating the AKT/mTOR pathway in non-small-cell lung cancer
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Xiaoyan Lin, Antoine M. Snijders, Xianqiang Liu, Guangwei Wei, Pengju Zhang, Jingchao Liu, Yi Xiao, Chunli Yin, Jian-Hua Mao, and Yige Wang
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0301 basic medicine ,Cancer Research ,Epithelial-Mesenchymal Transition ,Lung Neoplasms ,Mice, Nude ,Cell Cycle Proteins ,Biology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,Carcinoma, Non-Small-Cell Lung ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Gene silencing ,Neoplasm Invasiveness ,Gene Silencing ,Epithelial–mesenchymal transition ,Lung cancer ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,Cisplatin ,Mice, Inbred BALB C ,TOR Serine-Threonine Kinases ,General Medicine ,Prognosis ,medicine.disease ,respiratory tract diseases ,030104 developmental biology ,Oncology ,Drug Resistance, Neoplasm ,Tumor progression ,030220 oncology & carcinogenesis ,Cancer research ,Molecular Medicine ,Microtubule-Associated Proteins ,Proto-Oncogene Proteins c-akt ,Signal Transduction ,medicine.drug - Abstract
FAM83D has been proposed to act as an oncoprotein in several types of human cancer. Its role and mode of action in human non-small cell lung cancer (NSCLC) metastasis and its impact on chemotherapy are as yet, however, poorly understood. FAM83D expression was measured in NSCLC cells and normal lung epithelial cells, as well as in primary NSCLC tissues and corresponding adjacent non-cancerous tissues, using qRT-PCR, Western blotting and immunohistochemistry. FAM83D was stably overexpressed in BEAS2B cells or silenced in A549 and H1299 cells using retroviral or lentiviral vectors. The growth capacity of NSCLC cells was evaluated using MTT and colony formation assays. Epithelial-mesenchymal transition (EMT) was assessed using Western blotting and immunofluorescence. NSCLC cell invasive capacities were assessed using scratch wound healing and Boyden chamber assays. NSCLC cell viability in response to cisplatin treatment was assessed using MTT assays in vitro and a xenograft model in vivo. We found that FAM83D expression levels were significantly elevated in NSCLC cells and tissues, and positively correlated with tumor progression and a poor prognosis. Exogenous FAM83D overexpression promoted, while FAM83D silencing inhibited NSCLC cell proliferation, EMT and invasion. FAM83D silencing also reduced cisplatin resistance. Concordantly, we found that NSCLC patients with a low FAM83D expression benefited most from chemotherapy. Mechanistically, we found that FAM83D activated the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. Pharmacological treatment with either AKT or mTOR inhibitors reverted FAM83D-induced tumorigenic phenotypes. Our results suggest a role of FAM83D in NSCLC development. In addition, our results indicate that NSCLC patients exhibiting FAM83D overexpression are likely to benefit from AKT and/or mTOR inhibitor treatment.
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- 2020
193. Factors Associated With Minimum Effective Volume of Lidocaine 1.5% for Sciatic Nerve Blocks
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Bin Yu, Dandan Ling, Shuqi Xie, Mengying Wang, Junjie Luo, Xiaodan Cao, Jianfang Cao, Xiaorui Chen, and Xiaoyan Lin
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Lidocaine ,Positive correlation ,Loading dose ,03 medical and health sciences ,0302 clinical medicine ,Femoral nerve ,030202 anesthesiology ,medicine ,Humans ,Prospective Studies ,Anesthetics, Local ,Dose-Response Relationship, Drug ,business.industry ,Nerve Block ,Sciatic Nerve ,Compound muscle action potential ,Anesthesiology and Pain Medicine ,Anesthesia ,Plasma concentration ,Neurology (clinical) ,Sciatic nerve ,Effective volume ,business ,Femoral Nerve ,030217 neurology & neurosurgery ,medicine.drug - Abstract
OBJECTIVES The objectives of this study were to investigate the correlations between the minimum effective volume (MEV) of lidocaine 1.5% for an ultrasound-guided popliteal sciatic nerve block and individual factors including the cross-sectional nerve area, sex, age, body mass index, and the depth of the sciatic nerve and to evaluate the safety of combined femoral and sciatic nerve blocks by monitoring the plasma concentration of local anesthetics. METHODS Forty patients received combined single-shot femoral and continuous sciatic nerve blocks. The femoral nerve block was performed with an in-plane technique and 15 mL of lidocaine 1.5%. A continuous peripheral nerve block annular tube was positioned between the tibial and peroneal nerves inside the paraneural sheath. Thirty minutes after the femoral nerve block, a loading dose of 5 mL of lidocaine 1.5% was given to block the sciatic nerve after obtaining the maximum compound muscle action potential (CMAP) amplitude using nerve conduction studies. Additional lidocaine 1.5% was pumped at a rate of 30 mL/h through the indwelling annular tube if, after 8 minutes, the CMAP amplitude was still present. The CMAP amplitude monitored by the nerve conduction studies and pinprick tests were recorded every 2 minutes after the administration of lidocaine 1.5%. When the CMAP amplitude decreased to nearly 0 mV, this MEV was recorded. The influences of the cross-sectional area of the sciatic nerve, sex, age, body mass index, and the depth of the sciatic nerve on the MEV were analyzed using stepwise multiple linear regression. Blood samples were collected from 10 patients to evaluate the safety of combined femoral and sciatic nerve blocks by ultra-performance liquid chromatography-tandem mass spectrometry. Blood was drawn at 0 minutes before femoral nerve injection; 0 minutes before sciatic nerve injection; 8 minutes after sciatic nerve injection; and 0, 10, 20, 30, 45, 60, 75, 90, and 120 minutes after the pumping of lidocaine 1.5% stopped. RESULTS A significant correlation was found between the MEV of lidocaine 1.5% and the cross-sectional area of the sciatic nerve (r=0.459), with a regression equation of the MEV (mL)=5.969+0.095×(the cross-sectional area of the sciatic nerve). The coefficient of determination was 0.211 (P
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- 2020
194. Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting
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Tamar Green, Xiaoyan Lin, Lynne C. Huffman, Allan L. Reiss, Stefani O’Donoghue, Judith L. Ross, Joachim Hallmayer, David S. Hong, and Booil Jo
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0301 basic medicine ,Adolescent ,Hormone Replacement Therapy ,medicine.drug_class ,Turner Syndrome ,Physiology ,Biology ,Article ,White matter ,Genomic Imprinting ,03 medical and health sciences ,0302 clinical medicine ,Basal ganglia ,Turner syndrome ,medicine ,Humans ,Epigenetics ,Child ,Biological Psychiatry ,X chromosome ,Schools ,Brain ,Estrogens ,Voxel-based morphometry ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Estrogen ,Female ,Genomic imprinting ,030217 neurology & neurosurgery - Abstract
Background The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. Methods We described brain growth trajectories in 55 girls with TS and 53 typically developing girls (258 magnetic resonance imaging datasets) spanning 5 years. Using novel nonparametric and mixed effects analytic approaches, we evaluated influences of X chromosome genomic imprinting and hormone replacement therapy on brain development. Results Parieto-occipital gray and white matter regions showed slower growth during typical pubertal timing in girls with TS relative to typically developing girls. In contrast, some basal ganglia, cerebellar, and limited cortical areas showed enhanced volume growth with peaks around 10 years of age. Conclusions The parieto-occipital finding suggests that girls with TS may be particularly vulnerable to altered brain development during adolescence. Basal ganglia regions may be relatively preserved in TS owing to their maturational growth before or early in typical pubertal years. Taken together, our findings indicate that particular brain regions are more vulnerable to TS genetic and hormonal effects during puberty. These specific alterations in neurodevelopment may be more likely to affect long-term cognitive behavioral outcomes in young girls with this common genetic condition.
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- 2020
195. Necessary and sufficient conditions for oscillation of first-order nonlinear neutral difference equations.
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X. H. Tang and Xiaoyan Lin
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- 2008
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196. An X-ray focusing monochromator composed of poly-capillary X-ray lenses and highly oriented pyrolytic graphite
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Xiaoyan Lin, Yude Li, Mo Zhou, Xin Liu, Heng Luo, Jiayu Duan, and Xingyi Wang
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010302 applied physics ,Diffraction ,Nuclear and High Energy Physics ,Materials science ,010308 nuclear & particles physics ,business.industry ,X-ray ,01 natural sciences ,law.invention ,Crystal ,Lens (optics) ,Optics ,Highly oriented pyrolytic graphite ,law ,0103 physical sciences ,Vertical direction ,business ,Instrumentation ,Power density ,Monochromator - Abstract
An X-ray focusing monochromator is proposed, which is composed of an X-ray source, a highly oriented pyrolytic graphite and two poly-capillary X-ray lenses. Through the function of the front poly-capillary X-ray lens, the X-ray beams diffracted by the highly oriented pyrolytic graphite changed from a linear pattern with high divergence in the vertical direction, to a circular pattern with low divergence, and more X-rays are diffracted than the conventional monochromator of combining an X-ray source with a flat crystal. The post poly-capillary X-ray lens can focus the diffracted X-ray beams with low divergence into a small focal spot with high gain in power density. The results show that the gains of circular apertures with diameters of 320 and 100 μm are 12 and 22, respectively, at a distance of 221.5 mm away from the center of the highly oriented pyrolytic graphite.
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- 2019
197. ICBayes: a package of Bayesian semiparametric regression for intervel-censored data
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Lianming Wang, Chun Pan, Xiaoyan Lin, and Bo Cai
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Statistics and Probability ,Proportional hazards model ,Modeling and Simulation ,Probit model ,Bayesian probability ,Statistics ,Semiparametric regression ,Ordered logit ,Distributed File System ,Mathematics - Abstract
Interval-censored data arise frequently in medical studies of diseases that require periodic examinations for symptoms of interest, such as disease-free survival (DFS). This paper provides an intro...
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- 2019
198. Marinobacter sp. Stable Hydrous Titanium Oxide-Functionalized Bovine Serum Albumin Nanospheres for Uranium Capture from Spiked Seawater
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Xiaoyan Lin, Hui Liao, Shanlin Wang, Xuegang Luo, Jie Yu, Jian Zhou, Yongde Zhang, Meng Kuang, Tao Duan, and Wenkun Zhu
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inorganic chemicals ,Materials science ,Aqueous solution ,biology ,Extraction (chemistry) ,technology, industry, and agriculture ,chemistry.chemical_element ,02 engineering and technology ,010501 environmental sciences ,Uranium ,021001 nanoscience & nanotechnology ,complex mixtures ,01 natural sciences ,Titanium oxide ,Adsorption ,chemistry ,biology.protein ,General Materials Science ,Seawater ,Bovine serum albumin ,0210 nano-technology ,0105 earth and related environmental sciences ,Nuclear chemistry ,Titanium - Abstract
A novel nanospherical hydrous titanium oxide adsorbent (hydrous titanium oxide-immobilized bovine serum albumin nanospheres, HTO-BSA-NSs) was prepared by immobilizing HTOs with a manipulated molecular mass and number of active sites for uranium on the surface of BSA-NSs. The adsorption performances of HTO-BSA-NSs were investigated in spiked natural seawater with extra 8 ppm uranium. The results demonstrated that HTO-BSA-NSs are capable of uranium capture from a complex aqueous matrix with a low uranium concentration. Meanwhile, the microbial stability of HTO-BSA-NSs in sterilized natural seawater with Marinobacter sp. was investigated and observed through an optical microscope and TEM, revealing that the wrapped HTOs could protect the BSA-NSs from the decomposition of microorganisms, and the structure and functional groups of HTO-BSA-NSs remain stable compared with the BSA-NSs. In addition, the uranium adsorption mechanism of HTO-BSA-NSs is mainly recognized as dehydrated complexation, which was concluded from characterization analysis, adsorption model fitting, and theoretical calculations based on density functional theory. The remarkable uranium adsorption performance and microbial stability of HTO-BSA-NSs indicated that they have the potential to be a low-cost and environmentally friendly adsorbent for uranium extraction from complex environments such as seawater or uranium-containing industrial wastewater.
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- 2019
199. Effect of calcium chloride and 1-methylcyclopropene combined treatment on pectin degradation and textural changes of Eureka lemon during postharvest storage
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Kwame Eduam Baiden Frempong, Yan Chen, Lili Liang, and Xiaoyan Lin
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Applied Microbiology and Biotechnology ,Food Science ,Biotechnology - Abstract
During post-harvest storage, the cell wall properties are closely associated with the physical, chemical, and biological properties of the fruit. The degradation of pectin in the cell walls and middle lamella is critical to these properties. The effects of calcium chloride (CaCl₂) and 1-methylcyclopropene (1-MCP) combined treatment on the pectin degradation, texture, and peel color of Eureka lemon were investigated during post-harvest storage. The
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- 2021
200. Bayesian Inferences for Panel Count Data and Interval-Censored Data with Nonparametric Modeling of the Baseline Functions
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Lu Wang, Lianming Wang, and Xiaoyan Lin
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- 2021
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