151. Myelin oligodendrocyte glycoprotein-associated disorders are associated with HLA subtypes in a Chinese paediatric-onset cohort.
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Xiaobo Sun, Wei Qiu, Jingqi Wang, Shisi Wang, Yuge Wang, Xiaonan Zhong, Chunxin Liu, Chunping Cui, Hai Hong, Hui Yang, Xiao-Jing Li, Zhengqi Lu, Xueqiang Hu, Kermode, Allan G., Lisheng Peng, Sun, Xiaobo, Qiu, Wei, Wang, Jingqi, Wang, Shisi, and Wang, Yuge
- Subjects
MYASTHENIA gravis ,ANTI-NMDA receptor encephalitis ,MYELIN ,MYELIN oligodendrocyte glycoprotein ,POSTVACCINAL encephalitis ,CENTRAL nervous system diseases ,RESEARCH ,HLA-B27 antigen ,RESEARCH methodology ,AUTOIMMUNE diseases ,ALLELES ,EVALUATION research ,MEDICAL cooperation ,MEMBRANE glycoproteins ,COMPARATIVE studies ,GENOTYPES ,HAPLOTYPES ,LONGITUDINAL method - Abstract
Objective: Myelin oligodendrocyte glycoprotein-associated disorders (MOGADs) are a rare new neurological autoimmune disease with unclear pathogenesis. Since a linkage of the disease to the human leucocyte antigen (HLA) has not been shown, we here investigated whether MOGAD is associated with the HLA locus.Methods: HLA genotypes of 95 patients with MOGADs, assessed between 2016 and 2018 from three academic centres, were compared with 481 healthy Chinese Han individuals. Patients with MOGADs included 51 paediatric-onset and 44 adult-onset cases. All patients were seropositive for IgG targeting the myelin oligodendrocyte glycoprotein (MOG).Results: Paediatric-onset MOGAD was associated with the DQB1*05:02-DRB1*16:02 alleles (OR=2.43; OR=3.28) or haplotype (OR=2.84) of HLA class II genes. The prevalence of these genotypes in patients with paediatric-onset MOGAD was significantly higher than healthy controls (padj=0.0154; padj=0.0221; padj=0.0331). By contrast, adult-onset MOGAD was not associated with any HLA genotype. Clinically, patients with the DQB1*05:02-DRB1*16:02 haplotype exhibited significantly higher expanded disability status scale scores at onset (p=0.004) and were more likely to undergo a disease relapse (p=0.030). HLA-peptide binding prediction algorithms and computational docking analysis provided supporting evidence for the close relationship between the MOG peptide subunit and DQB1*05:02 allele. In vitro results indicated that site-specific mutations of the predicted target sequence reduced the antigen-antibody binding, especially in the paediatric-onset group with DQB1*05:02 allele.Conclusions: This study demonstrates a possible association between specific HLA class II alleles and paediatric-onset MOGAD, providing evidence for the conjecture that different aetiology and pathogenesis likely underlie paediatric-onset and adult-onset cases of MOGAD. [ABSTRACT FROM AUTHOR]- Published
- 2020
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