151. Associations between endothelial nitric oxide synthase polymorphisms and risk of diabetic nephropathy: an updated meta-analysis
- Author
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Xian-Tao Zeng, Yancheng Xu, Yong Zhang, Hong-Xia Zuo, and Hou-qin Xiao
- Subjects
Oncology ,medicine.medical_specialty ,Nitric Oxide Synthase Type III ,Critical Care and Intensive Care Medicine ,Diabetic nephropathy ,Asian People ,Risk Factors ,Enos ,Internal medicine ,medicine ,Humans ,Diabetic Nephropathies ,Allele ,Polymorphism, Genetic ,biology ,business.industry ,General Medicine ,Odds ratio ,Publication bias ,medicine.disease ,biology.organism_classification ,Confidence interval ,Endocrinology ,Nephrology ,Meta-analysis ,business - Abstract
Genetic polymorphism of endothelial nitric oxide synthase (eNOS) has been implicated in the risk of diabetic nephropathy (DN), but the published findings were inconsistent. We performed a comprehensive meta-analysis to derive a more precise estimation of the association between genetic polymorphisms of eNOS and the risk of DN.Six online database were researched on the associations between polymorphisms of eNOS (T786C, G894T, 4b/4a) and DN risk. PRISMA statement and Hardy-Weinberg equilibrium assessment were used in this report. Odds ratio and 95% confidence interval were estimated based on the following genetic contrast/models: allelic model, dominant model, recessive model and co-dominant model. The publication bias and sensitivity analysis were also performed to guarantee the statistical power.A total of 49 case-control studies with 11,990/9754/5131 participants for DN/DM/HC group were eligible for meta-analysis (7/25/31 studies for T786C/G984T/4b/a). For the eNOS-T786C, C allele showed a weak association between C allele and DN risk in DN/T2DM group. For eNOS-G894T, there was an association between T allele and DN risk in the global, Asian and African population in DN/T2DM group. For the eNOS-4b/4a, 4a allele was found contributing significantly to increased DN risk in the global population.Our comprehensive meta-analysis suggests that three polymorphisms of eNOS may be the increased risk factors of DN development, especially in Asian population and T2DM group.
- Published
- 2015