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2,428 results on '"Wurm, P."'

154. Short-term transcutaneous vagus nerve stimulation increases pupil size but does not affect EEG alpha power: A replication of Sharon et al. (2021, Journal of Neuroscience)

Author

Beth Lloyd, Franz Wurm, Roy de Kleijn, and Sander Nieuwenhuis

Subjects
taVNS, tVNS, Tenth cranial nerve, Pupillometry, Alpha desynchronization, Reproducibility, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a potential treatment for pharmaco-resistant epilepsy and depression. Its clinical efficacy is thought to depend on taVNS-induced activation of the locus coeruleus and other neuromodulator systems. However, unlike for invasive VNS in rodents, there is little evidence for an effect of taVNS on noradrenergic activity. Objective: We attempted to replicate recently published findings by Sharon et al. (2021), showing that short bursts of taVNS transiently increased pupil size and decreased EEG alpha power, two correlates of central noradrenergic activity. Methods: Following the original study, we used a single-blind, sham-controlled, randomized cross-over design. Human volunteers (n = 29) received short-term (3.4 s) taVNS at the maximum level below the pain threshold, while we collected resting-state pupil-size and EEG data. To analyze the data, we used scripts provided by Sharon and colleagues. Results: Consistent with Sharon et al. (2021), pupil dilation was significantly larger during taVNS than during sham stimulation (p = .009; Bayes factor supporting the difference = 7.45). However, we failed to replicate the effect of taVNS on EEG alpha power (p = .37); the data were four times more likely under the null hypothesis (BF10 = 0.28). Conclusion: Our findings support the effectiveness of short-term taVNS in inducing transient pupil dilation, a correlate of phasic noradrenergic activity. However, we failed to replicate the recent finding by Sharon et al. (2021) that taVNS attenuates EEG alpha activity. Overall, this study highlights the need for continued research on the neural mechanisms underlying taVNS efficacy and its potential as a treatment option for pharmaco-resistant conditions. It also highlights the need for direct replications of influential taVNS studies.

Published
2023
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155. Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers

Author

Olga Koshkina, Timo Rheinberger, Vera Flocke, Anton Windfelder, Pascal Bouvain, Naomi M. Hamelmann, Jos M. J. Paulusse, Hubert Gojzewski, Ulrich Flögel, and Frederik R. Wurm

Subjects
Science
Abstract

Abstract In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration. Magnetic resonance imaging (MRI) is a whole-body imaging technique, and heteronuclear MRI allows quantitative imaging. However, MRI agents can result in environmental pollution and organ accumulation. To address this, we introduce biocompatible and biodegradable polyphosphoesters, as MRI-traceable polymers using the 31P centers in the polymer backbone. We overcome challenges in 31P MRI, including background interference and low sensitivity, by modifying the molecular environment of 31P, assembling polymers into colloids, and tailoring the polymers’ microstructure to adjust MRI-relaxation times. Specifically, gradient-type polyphosphonate-copolymers demonstrate improved MRI-relaxation times compared to homo- and block copolymers, making them suitable for imaging. We validate background-free imaging and biodegradation in vivo using Manduca sexta. Furthermore, encapsulating the potent drug PROTAC allows using these amphiphilic copolymers to simultaneously deliver drugs, enabling theranostics. This first report paves the way for polyphosphoesters as background-free MRI-traceable polymers for theranostic applications.

Published
2023
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156. Predictive neural representations of naturalistic dynamic input

Author

Ingmar E. J. de Vries and Moritz F. Wurm

Subjects
Science
Abstract

Abstract Adaptive behavior such as social interaction requires our brain to predict unfolding external dynamics. While theories assume such dynamic prediction, empirical evidence is limited to static snapshots and indirect consequences of predictions. We present a dynamic extension to representational similarity analysis that uses temporally variable models to capture neural representations of unfolding events. We applied this approach to source-reconstructed magnetoencephalography (MEG) data of healthy human subjects and demonstrate both lagged and predictive neural representations of observed actions. Predictive representations exhibit a hierarchical pattern, such that high-level abstract stimulus features are predicted earlier in time, while low-level visual features are predicted closer in time to the actual sensory input. By quantifying the temporal forecast window of the brain, this approach allows investigating predictive processing of our dynamic world. It can be applied to other naturalistic stimuli (e.g., film, soundscapes, music, motor planning/execution, social interaction) and any biosignal with high temporal resolution.

Published
2023
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157. Borexino’s search for low-energy neutrinos associated with gravitational wave events from GWTC-3 database

Author

D. Basilico, G. Bellini, J. Benziger, R. Biondi, B. Caccianiga, F. Calaprice, A. Caminata, A. Chepurnov, D. D’Angelo, A. Derbin, A. Di Giacinto, V. Di Marcello, X. F. Ding, A. Di Ludovico, L. Di Noto, I. Drachnev, D. Franco, C. Galbiati, C. Ghiano, M. Giammarchi, A. Goretti, M. Gromov, D. Guffanti, Aldo Ianni, Andrea Ianni, A. Jany, V. Kobychev, G. Korga, S. Kumaran, M. Laubenstein, E. Litvinovich, P. Lombardi, I. Lomskaya, L. Ludhova, I. Machulin, J. Martyn, E. Meroni, L. Miramonti, M. Misiaszek, V. Muratova, R. Nugmanov, L. Oberauer, V. Orekhov, F. Ortica, M. Pallavicini, L. Pelicci, Ö. Penek, L. Pietrofaccia, N. Pilipenko, A. Pocar, G. Raikov, M. T. Ranalli, G. Ranucci, A. Re, N. Rossi, S. Schönert, D. Semenov, G. Settanta, M. Skorokhvatov, A. Singhal, O. Smirnov, A. Sotnikov, R. Tartaglia, G. Testera, E. Unzhakov, A. Vishneva, R. B. Vogelaar, F. von Feilitzsch, M. Wojcik, M. Wurm, S. Zavatarelli, K. Zuber, and G. Zuzel

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The search for neutrino events in correlation with gravitational wave (GW) events for three observing runs (O1, O2 and O3) from 09/2015 to 03/2020 has been performed using the Borexino data-set of the same period. We have searched for signals of neutrino-electron scattering and inverse beta-decay (IBD) within a time window of $$\pm \, 1000$$ ± 1000 s centered at the detection moment of a particular GW event. The search was done with three visible energy thresholds of 0.25, 0.8 and 3.0 MeV. Two types of incoming neutrino spectra were considered: the mono-energetic line and the supernova-like spectrum. GW candidates originated by merging binaries of black holes (BHBH), neutron stars (NSNS) and neutron star and black hole (NSBH) were analyzed separately. Additionally, the subset of most intensive BHBH mergers at closer distances and with larger radiative mass than the rest was considered. In total, follow-ups of 74 out of 93 gravitational waves reported in the GWTC-3 catalog were analyzed and no statistically significant excess over the background was observed. As a result, the strongest upper limits on GW-associated neutrino and antineutrino fluences for all flavors ( $$\nu _e, \nu _\mu , \nu _\tau $$ ν e , ν μ , ν τ ) at the level $$10^9{-}10^{15}~\textrm{cm}^{-2}\,\textrm{GW}^{-1}$$ 10 9 - 10 15 cm - 2 GW - 1 have been obtained in the 0.5–5 MeV neutrino energy range.

Published
2023
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158. Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes

Author

Sara Silvaieh, Theresa König, Raphael Wurm, Tandis Parvizi, Evelyn Berger-Sieczkowski, Stella Goeschl, Christoph Hotzy, Matias Wagner, Riccardo Berutti, Esther Sammler, Elisabeth Stögmann, and Alexander Zimprich

Subjects
Early-onset dementia, Whole-exome sequencing, Genetic variants, Medicine, Genetics, QH426-470
Abstract

Abstract Early-onset dementia (EOD), with symptom onset before age 65, has a strong genetic burden. Due to genetic and clinical overlaps between different types of dementia, whole-exome sequencing (WES) has emerged as an appropriate screening method for diagnostic testing and novel gene-finding approaches. We performed WES and C9orf72 repeat testing in 60 well-defined Austrian EOD patients. Seven patients (12%) carried likely disease-causing variants in monogenic genes, PSEN1, MAPT, APP, and GRN. Five patients (8%) were APOE4 homozygote carriers. Definite and possible risk variants were detected in the genes TREM2, SORL1, ABCA7 and TBK1. In an explorative approach, we cross-checked rare gene variants in our cohort with a curated neurodegeneration candidate gene list and identified DCTN1, MAPK8IP3, LRRK2, VPS13C and BACE1 as promising candidate genes. Conclusively, 12 cases (20%) carried variants relevant to patient counseling, comparable to previously reported studies, and can thus be considered genetically resolved. Reduced penetrance, oligogenic inheritance and not yet identified high-risk genes might explain the high number of unresolved cases. To address this issue, we provide complete genetic and phenotypic information (uploaded to the European Genome-phenome Archive), enabling other researchers to cross-check variants. Thereby, we hope to increase the chance of independently finding the same gene/variant-hit in other well-defined EOD patient cohorts, thus confirming new genetic risk variants or variant combinations.

Published
2023
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159. A shared neural code for the physics of actions and object events

Author

Seda Karakose-Akbiyik, Alfonso Caramazza, and Moritz F. Wurm

Subjects
Science
Abstract

Abstract Observing others’ actions recruits frontoparietal and posterior temporal brain regions – also called the action observation network. It is typically assumed that these regions support recognizing actions of animate entities (e.g., person jumping over a box). However, objects can also participate in events with rich meaning and structure (e.g., ball bouncing over a box). So far, it has not been clarified which brain regions encode information specific to goal-directed actions or more general information that also defines object events. Here, we show a shared neural code for visually presented actions and object events throughout the action observation network. We argue that this neural representation captures the structure and physics of events regardless of animacy. We find that lateral occipitotemporal cortex encodes information about events that is also invariant to stimulus modality. Our results shed light onto the representational profiles of posterior temporal and frontoparietal cortices, and their roles in encoding event information.

Published
2023
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160. Susceptibility and infectiousness of SARS-CoV-2 in children versus adults, by variant (wild-type, alpha, delta): A systematic review and meta-analysis of household contact studies.

Author

Olalekan A Uthman, Frederik Plesner Lyngse, Seun Anjorin, Barbara Hauer, Seran Hakki, Diego A Martinez, Yang Ge, Jakob Jonnerby, Cathinka Halle Julin, Gary Lin, Ajit Lalvani, Julika Loss, Kieran J Madon, Leonardo Martinez, Lisbeth Meyer Næss, Kathleen R Page, Diana Prieto, Anna Hayman Robertson, Ye Shen, Juliane Wurm, and Udo Buchholz

Subjects
Medicine, Science
Abstract

ImportanceUnderstanding the susceptibility and infectiousness of children and adolescents in comparison to adults is important to appreciate their role in the COVID-19 pandemic.ObjectiveTo determine SARS-CoV-2 susceptibility and infectiousness of children and adolescents with adults as comparator for three variants (wild-type, alpha, delta) in the household setting. We aimed to identify the effects independent of vaccination or prior infection.Data sourcesWe searched EMBASE, PubMed and medRxiv up to January 2022.Study selectionTwo reviewers independently identified studies providing secondary household attack rates (SAR) for SARS-CoV-2 infection in children (0-9 years), adolescents (10-19 years) or both compared with adults (20 years and older).Data extraction and synthesisTwo reviewers independently extracted data, assessed risk of bias and performed a random-effects meta-analysis model.Main outcomes and measuresOdds ratio (OR) for SARS-CoV-2 infection comparing children and adolescents with adults stratified by wild-type (ancestral type), alpha, and delta variant, respectively. Susceptibility was defined as the secondary attack rate (SAR) among susceptible household contacts irrespective of the age of the index case. Infectiousness was defined as the SAR irrespective of the age of household contacts when children/adolescents/adults were the index case.ResultsSusceptibility analysis: We included 27 studies (308,681 contacts), for delta only one (large) study was available. Compared to adults, children and adolescents were less susceptible to the wild-type and delta, but equally susceptible to alpha. Infectiousness analysis: We included 21 studies (201,199 index cases). Compared to adults, children and adolescents were less infectious when infected with the wild-type and delta. Alpha -related infectiousness remained unclear, 0-9 year old children were at least as infectious as adults. Overall SAR among household contacts varied between the variants.Conclusions and relevanceWhen considering the potential role of children and adolescents, variant-specific susceptibility, infectiousness, age group and overall transmissibility need to be assessed.

Published
2024
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162. Calibration Strategy of the JUNO Experiment

Author

JUNO collaboration, Abusleme, Angel, Adam, Thomas, Ahmad, Shakeel, Ahmed, Rizwan, Aiello, Sebastiano, Akram, Muhammad, An, Fengpeng, An, Guangpeng, An, Qi, Andronico, Giuseppe, Anfimov, Nikolay, Antonelli, Vito, Antoshkina, Tatiana, Asavapibhop, Burin, de André, João Pedro Athayde Marcondes, Auguste, Didier, Babic, Andrej, Baldini, Wander, Barresi, Andrea, Baussan, Eric, Bellato, Marco, Bergnoli, Antonio, Bernieri, Enrico, Birkenfeld, Thilo, Blin, Sylvie, Blum, David, Blyth, Simon, Bolshakova, Anastasia, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Brigatti, Augusto, Brugnera, Riccardo, Bruno, Riccardo, Budano, Antonio, Buscemi, Mario, Busto, Jose, Butorov, Ilya, Cabrera, Anatael, Cai, Hao, Cai, Xiao, Cai, Yanke, Cai, Zhiyan, Cammi, Antonio, Campeny, Agustin, Cao, Chuanya, Cao, Guofu, Cao, Jun, Caruso, Rossella, Cerna, Cédric, Chang, Jinfan, Chang, Yun, Chen, Pingping, Chen, Po-An, Chen, Shaomin, Chen, Shenjian, Chen, Xurong, Chen, Yi-Wen, Chen, Yixue, Chen, Yu, Chen, Zhang, Cheng, Jie, Cheng, Yaping, Chiesa, Davide, Chimenti, Pietro, Chukanov, Artem, Chuvashova, Anna, Claverie, Gérard, Clementi, Catia, Clerbaux, Barbara, Di Lorenzo, Selma Conforti, Corti, Daniele, Costa, Salvatore, Corso, Flavio Dal, Dalager, Olivia, De La Taille, Christophe, Deng, Jiawei, Deng, Zhi, Deng, Ziyan, Depnering, Wilfried, Diaz, Marco, Ding, Xuefeng, Ding, Yayun, Dirgantara, Bayu, Dmitrievsky, Sergey, Dohnal, Tadeas, Donchenko, Georgy, Dong, Jianmeng, Dornic, Damien, Doroshkevich, Evgeny, Dracos, Marcos, Druillole, Frédéric, Du, Shuxian, Dusini, Stefano, Dvorak, Martin, Enqvist, Timo, Enzmann, Heike, Fabbri, Andrea, Fajt, Lukas, Fan, Donghua, Fan, Lei, Fang, Can, Fang, Jian, Fargetta, Marco, Fatkina, Anna, Fedoseev, Dmitry, Fekete, Vladko, Feng, Li-Cheng, Feng, Qichun, Ford, Richard, Formozov, Andrey, Fournier, Amélie, Gan, Haonan, Gao, Feng, Garfagnini, Alberto, Göttel, Alexandre, Genster, Christoph, Giammarchi, Marco, Giaz, Agnese, Giudice, Nunzio, Giuliani, Franco, Gonchar, Maxim, Gong, Guanghua, Gong, Hui, Gorchakov, Oleg, Gornushkin, Yuri, Grassi, Marco, Grewing, Christian, Gromov, Vasily, Gu, Minghao, Gu, Xiaofei, Gu, Yu, Guan, Mengyun, Guardone, Nunzio, Gul, Maria, Guo, Cong, Guo, Jingyuan, Guo, Wanlei, Guo, Xinheng, Guo, Yuhang, Hackspacher, Paul, Hagner, Caren, Han, Ran, Han, Yang, Hassan, Muhammad, He, Miao, He, Wei, Heinz, Tobias, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hong, Daojin, Hor, YuenKeung, Hou, Shaojing, Hsiung, Yee, Hu, Bei-Zhen, Hu, Hang, Hu, Jianrun, Hu, Jun, Hu, Shouyang, Hu, Tao, Hu, Zhuojun, Huang, Chunhao, Huang, Guihong, Huang, Hanxiong, Huang, Qinhua, Huang, Wenhao, Huang, Xingtao, Huang, Yongbo, Hui, Jiaqi, Huo, Lei, Huo, Wenju, Huss, Cédric, Hussain, Safeer, Insolia, Antonio, Ioannisian, Ara, Isocrate, Roberto, Jelmini, Beatrice, Jen, Kuo-Lun, Ji, Xiaolu, Ji, Xingzhao, Jia, Huihui, Jia, Junji, Jian, Siyu, Jiang, Di, Jiang, Xiaoshan, Jin, Ruyi, Jing, Xiaoping, Jollet, Cécile, Joutsenvaara, Jari, Jungthawan, Sirichok, Kalousis, Leonidas, Kampmann, Philipp, Kang, Li, Karagounis, Michael, Kazarian, Narine, Khan, Amir, Khan, Waseem, Khosonthongkee, Khanchai, Kinz, Patrick, Korablev, Denis, Kouzakov, Konstantin, Krasnoperov, Alexey, Krokhaleva, Svetlana, Krumshteyn, Zinovy, Kruth, Andre, Kutovskiy, Nikolay, Kuusiniemi, Pasi, Lachenmaier, Tobias, Landini, Cecilia, Leblanc, Sébastien, Lebrin, Victor, Lefevre, Frederic, Lei, Ruiting, Leitner, Rupert, Leung, Jason, Li, Demin, Li, Fei, Li, Fule, Li, Haitao, Li, Huiling, Li, Jiaqi, Li, Jin, Li, Kaijie, Li, Mengzhao, Li, Nan, Li, Qingjiang, Li, Ruhui, Li, Shanfeng, Li, Shuaijie, Li, Tao, Li, Weidong, Li, Weiguo, Li, Xiaomei, Li, Xiaonan, Li, Xinglong, Li, Yi, Li, Yufeng, Li, Zhibing, Li, Ziyuan, Liang, Hao, Liang, Jingjing, Liebau, Daniel, Limphirat, Ayut, Limpijumnong, Sukit, Lin, Guey-Lin, Lin, Shengxin, Lin, Tao, Ling, Jiajie, Lippi, Ivano, Liu, Fang, Liu, Haidong, Liu, Hongbang, Liu, Hongjuan, Liu, Hongtao, Liu, Hu, Liu, Hui, Liu, Jianglai, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shuangyu, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Yan, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Shuxiang, Lu, Xiaoxu, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Luo, Fengjiao, Luo, Guang, Luo, Pengwei, Luo, Shu, Luo, Wuming, Lyashuk, Vladimir, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Malyshkin, Yury, Mantovani, Fabio, Manzali, Francesco, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Marium, Sadia, Martellini, Cristina, Martin-Chassard, Gisele, Martini, Agnese, Mayilyan, Davit, Müller, Axel, Mednieks, Ints, Meng, Yue, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Mezzetto, Mauro, Miller, Jonathan, Miramonti, Lino, Monforte, Salvatore, Montini, Paolo, Montuschi, Michele, Morozov, Nikolay, Muhammad, Waqas, Muralidharan, Pavithra, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Nemchenok, Igor, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Pan, Hsiao-Ru, Paoloni, Alessandro, Parkalian, Nina, Parmeggiano, Sergio, Payupol, Teerapat, Pei, Yatian, Pelliccia, Nicomede, Peng, Anguo, Peng, Haiping, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Rico, Luis Felipe Piñeres, Pilarczyk, Oliver, Popov, Artyom, Poussot, Pascal, Pratumwan, Wathan, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qian, Sen, Qian, Xiaohui, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Rajput, Muhammad, Ranucci, Gioacchino, Raper, Neill, Re, Alessandra, Rebber, Henning, Rebii, Abdel, Ren, Bin, Ren, Jie, Rezinko, Taras, Ricci, Barbara, Robens, Markus, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Roth, Christian, Ruan, Xiangdong, Ruan, Xichao, Rujirawat, Saroj, Rybnikov, Arseniy, Sadovsky, Andrey, Saggese, Paolo, Salamanna, Giuseppe, Sanfilippo, Simone, Sangka, Anut, Sanguansak, Nuanwan, Sawangwit, Utane, Sawatzki, Julia, Sawy, Fatma, Schever, Michaela, Schuler, Jacky, Schwab, Cédric, Schweizer, Konstantin, Selivanov, Dmitry, Selyunin, Alexandr, Serafini, Andrea, Settanta, Giulio, Settimo, Mariangela, Shao, Zhuang, Sharov, Vladislav, Shi, Jingyan, Shutov, Vitaly, Sidorenkov, Andrey, Šimkovic, Fedor, Sirignano, Chiara, Siripak, Jaruchit, Sisti, Monica, Slupecki, Maciej, Smirnov, Mikhail, Smirnov, Oleg, Sogo-Bezerra, Thiago, Songwadhana, Julanan, Soonthornthum, Boonrucksar, Sotnikov, Albert, Sramek, Ondrej, Sreethawong, Warintorn, Stahl, Achim, Stanco, Luca, Stankevich, Konstantin, Štefánik, Dušan, Steiger, Hans, Steinmann, Jochen, Sterr, Tobias, Stock, Matthias Raphael, Strati, Virginia, Studenikin, Alexander, Sun, Gongxing, Sun, Shifeng, Sun, Xilei, Sun, Yongjie, Sun, Yongzhao, Suwonjandee, Narumon, Szelezniak, Michal, Tang, Jian, Tang, Qiang, Tang, Quan, Tang, Xiao, Tietzsch, Alexander, Tkachev, Igor, Tmej, Tomas, Treskov, Konstantin, Triossi, Andrea, Troni, Giancarlo, Trzaska, Wladyslaw, Tuve, Cristina, van Waasen, Stefan, Boom, Johannes van den, Vanroyen, Guillaume, Vassilopoulos, Nikolaos, Vedin, Vadim, Verde, Giuseppe, Vialkov, Maxim, Viaud, Benoit, Volpe, Cristina, Vorobel, Vit, Votano, Lucia, Walker, Pablo, Wang, Caishen, Wang, Chung-Hsiang, Wang, En, Wang, Guoli, Wang, Jian, Wang, Jun, Wang, Kunyu, Wang, Lu, Wang, Meifen, Wang, Meng, Wang, Ruiguang, Wang, Siguang, Wang, Wei, Wang, Wenshuai, Wang, Xi, Wang, Xiangyue, Wang, Yangfu, Wang, Yaoguang, Wang, Yi, Wang, Yifang, Wang, Yuanqing, Wang, Yuman, Wang, Zhe, Wang, Zheng, Wang, Zhimin, Wang, Zongyi, Watcharangkool, Apimook, Wei, Lianghong, Wei, Wei, Wei, Yadong, Wen, Liangjian, Wiebusch, Christopher, Wong, Steven Chan-Fai, Wonsak, Bjoern, Wu, Diru, Wu, Fangliang, Wu, Qun, Wu, Wenjie, Wu, Zhi, Wurm, Michael, Wurtz, Jacques, Wysotzki, Christian, Xi, Yufei, Xia, Dongmei, Xiao, Mengjiao, Xie, Yuguang, Xie, Zhangquan, Xing, Zhizhong, Xu, Benda, Xu, Cheng, Xu, Donglian, Xu, Fanrong, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Xiongbo, Yan, Yupeng, Yang, Anbo, Yang, Changgen, Yang, Huan, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yao, Haifeng, Yasin, Zafar, Ye, Jiaxuan, Ye, Mei, Ye, Ziping, Yegin, Ugur, Yermia, Frédéric, Yi, Peihuai, Yin, Xiangwei, You, Zhengyun, Yu, Boxiang, Yu, Chiye, Yu, Chunxu, Yu, Hongzhao, Yu, Miao, Yu, Xianghui, Yu, Zeyuan, Yuan, Chengzhuo, Yuan, Ying, Yuan, Zhenxiong, Yuan, Ziyi, Yue, Baobiao, Zafar, Noman, Zambanini, Andre, Zeng, Shan, Zeng, Tingxuan, Zeng, Yuda, Zhan, Liang, Zhang, Feiyang, Zhang, Guoqing, Zhang, Haiqiong, Zhang, Honghao, Zhang, Jiawen, Zhang, Jie, Zhang, Jingbo, Zhang, Peng, Zhang, Qingmin, Zhang, Shiqi, Zhang, Shu, Zhang, Tao, Zhang, Xiaomei, Zhang, Xuantong, Zhang, Yan, Zhang, Yinhong, Zhang, Yiyu, Zhang, Yongpeng, Zhang, Yuanyuan, Zhang, Yumei, Zhang, Zhenyu, Zhang, Zhijian, Zhao, Fengyi, Zhao, Jie, Zhao, Rong, Zhao, Shujun, Zhao, Tianchi, Zheng, Dongqin, Zheng, Hua, Zheng, Minshan, Zheng, Yangheng, Zhong, Weirong, Zhou, Jing, Zhou, Li, Zhou, Nan, Zhou, Shun, Zhou, Xiang, Zhu, Jiang, Zhu, Kejun, Zhuang, Honglin, Zong, Liang, and Zou, Jiaheng

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We present the calibration strategy for the 20 kton liquid scintillator central detector of the Jiangmen Underground Neutrino Observatory (JUNO). By utilizing a comprehensive multiple-source and multiple-positional calibration program, in combination with a novel dual calorimetry technique exploiting two independent photosensors and readout systems, we demonstrate that the JUNO central detector can achieve a better than 1% energy linearity and a 3% effective energy resolution, required by the neutrino mass ordering determination.

Published
2020
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163. Sensitivity of the SHiP experiment to dark photons decaying to a pair of charged particles

Author

SHiP Collaboration, Ahdida, C., Akmete, A., Albanese, R., Alexandrov, A., Anokhina, A., Aoki, S., Arduini, G., Atkin, E., Azorskiy, N., Back, J. J., Bagulya, A., Santos, F. Baaltasar Dos, Baranov, A., Bardou, F., Barker, G. J., Battistin, M., Bauche, J., Bay, A., Bayliss, V., Bencivenni, G., Berdnikov, A. Y., Berdnikov, Y. A., Bertani, M., Betancourt, C., Bezshyiko, I., Bezshyyko, O., Bick, D., Bieschke, S., Blanco, A., Boehm, J., Bogomilov, M., Boiarska, I., Bondarenko, K., Bonivento, W. M., Borburgh, J., Boyarsky, A., Brenner, R., Breton, D., Büscher, V., Buonaura, A., Buontempo, S., Cadeddu, S., Calcaterra, A., Calviani, M., Campanelli, M., Casolino, M., Charitonidis, N., Chau, P., Chauveau, J., Chepurnov, A., Chernyavskiy, M., Choi, K. -Y., Chumakov, A., Ciambrone, P., Cicero, V., Congedo, L., Cornelis, K., Cristinziani, M., Crupano, A., Dallavalle, G. M., Datwyler, A., D'Ambrosio, N., D'Appollonio, G., de Asmundis, R., Saraiva, J. De Carvalho, De Lellis, G., de Magistris, M., De Roeck, A., De Serio, M., De Simone, D., Dedenko, L., Dergachev, P., Di Crescenzo, A., Di Giulio, L., Di Marco, N., Dib, C., Dijkstra, H., Dmitrenko, V., Dougherty, L. A., Dolmatov, A., Domenici, D., Donskov, S., Drohan, V., Dubreuil, A., Durhan, O., Ehlert, M., Elikkaya, E., Enik, T., Etenko, A., Fabbri, F., Fedin, O., Fedotovs, F., Felici, G., Ferrillo, M., Ferro-Luzzi, M., Filippov, K., Fini, R. A., Fonte, P., Franco, C., Fraser, M., Fresa, R., Froeschl, R., Fukuda, T., Galati, G., Gall, J., Gatignon, L., Gavrilov, G., Gentile, V., Goddard, B., Golinka-Bezshyyko, L., Golovatiuk, A., Golovtsov, V., Golubkov, D., Golutvin, A., Gorbounov, P., Gorbunov, D., Gorbunov, S., Gorkavenko, V., Gorshenkov, M., Grachev, V., Grandchamp, A. L., Graverini, E., Grenard, J. -L., Grenier, D., Grichine, V., Gruzinskii, N., Guler, A. M., Guz, Yu., Haefeli, G. J., Hagner, C., Hakobyan, H., Harris, I. W., van Herwijnen, E., Hessler, C., Hollnagel, A., Hosseini, B., Hushchyn, M., Iaselli, G., Iuliano, A., Jacobsson, R., Joković, D., Jonker, M., Kadenko, I., Kain, V., Kaiser, B., Kamiscioglu, C., Karpenkov, D., Kershaw, K., Khabibullin, M., Khalikov, E., Khaustov, G., Khoriauli, G., Khotyantsev, A., Kim, Y. G., Kim, V., Kitagawa, N., Ko, J. -W., Kodama, K., Kolesnikov, A., Kolev, D. I., Kolosov, V., Komatsu, M., Kono, A., Konovalova, N., Kormannshaus, S., Korol, I., Korol'ko, I., Korzenev, A., Kostyukhin, V., Platia, E. Koukovini, Kovalenko, S., Krasilnikova, I., Kudenko, Y., Kurbatov, E., Kurbatov, P., Kurochka, V., Kuznetsova, E., Lacker, H. M., Lamont, M., Lanfranchi, G., Lantwin, O., Lauria, A., Lee, K. S., Lee, K. Y., Lévy, J. -M., Loschiavo, V. P., Lopes, L., Sola, E. Lopez, Lyubovitskij, V., Maalmi, J., Magnan, A. -M., Maleev, V., Malinin, A., Manabe, Y., Managadze, A. K., Manfredi, M., Marsh, S., Marshall, A. M., Mefodev, A., Mermod, P., Miano, A., Mikado, S., Mikhaylov, Yu., Milstead, D. A., Mineev, O., Montanari, A., Montesi, M. C., Morishima, K., Movchan, S., Muttoni, Y., Naganawa, N., Nakamura, M., Nakano, T., Nasybulin, S., Ninin, P., Nishio, A., Novikov, A., Obinyakov, B., Ogawa, S., Okateva, N., Opitz, B., Osborne, J., Ovchynnikov, M., Owtscharenko, N., Owen, P. H., Pacholek, P., Paoloni, A., Park, B. D., Pastore, A., Patel, M., Pereyma, D., Perillo-Marcone, A., Petkov, G. L., Petridis, K., Petrov, A., Podgrudkov, D., Poliakov, V., Polukhina, N., Prieto, J. Prieto, Prokudin, M., Prota, A., Quercia, A., Rademakers, A., Rakai, A., Ratnikov, F., Rawlings, T., Redi, F., Ricciardi, S., Rinaldesi, M., Rodin, Volodymyr, Rodin, Viktor, Robbe, P., Cavalcante, A. B. Rodrigues, Roganova, T., Rokujo, H., Rosa, G., Rovelli, T., Ruchayskiy, O., Ruf, T., Samoylenko, V., Samsonov, V., Galan, F. Sanchez, Diaz, P. Santos, Ull, A. Sanz, Saputi, A., Sato, O., Savchenko, E. S., Schliwinski, J. S., Schmidt-Parzefall, W., Serra, N., Sgobba, S., Shadura, O., Shakin, A., Shaposhnikov, M., Shatalov, P., Shchedrina, T., Shchutska, L., Shevchenko, V., Shibuya, H., Shirobokov, S., Shustov, A., Silverstein, S. B., Simone, S., Simoniello, R., Skorokhvatov, M., Smirnov, S., Sohn, J. Y., Sokolenko, A., Solodko, E., Starkov, N., Stoel, L., Stramaglia, M. E., Sukhonos, D., Suzuki, Y., Takahashi, S., Tastet, J. L., Teterin, P., Naing, S. Than, Timiryasov, I., Tioukov, V., Tommasini, D., Torii, M., Tosi, N., Treille, D., Tsenov, R., Ulin, S., Ursov, E., Ustyuzhanin, A., Uteshev, Z., Uvarov, L., Vankova-Kirilova, G., Vannucci, F., Venturi, V., Vilchinski, S., Vincke, Heinz, Vincke, Helmut, Visone, C., Vlasik, K., Volkov, A., Voronkov, R., van Waasen, S., Wanke, R., Wertelaers, P., Williams, O., Woo, J. -K., Wurm, M., Xella, S., Yilmaz, D., Yilmazer, A. U., Yoon, C. S., Zaytsev, Yu., Zelenov, A., and Zimmerman, J.

Subjects
High Energy Physics - Experiment
Abstract

Dark photons are hypothetical massive vector particles that could mix with ordinary photons. The simplest theoretical model is fully characterised by only two parameters: the mass of the dark photon m$_{\gamma^{\mathrm{D}}}$ and its mixing parameter with the photon, $\varepsilon$. The sensitivity of the SHiP detector is reviewed for dark photons in the mass range between 0.002 and 10 GeV. Different production mechanisms are simulated, with the dark photons decaying to pairs of visible fermions, including both leptons and quarks. Exclusion contours are presented and compared with those of past experiments. The SHiP detector is expected to have a unique sensitivity for m$_{\gamma^{\mathrm{D}}}$ ranging between 0.8 and 3.3$^{+0.2}_{-0.5}$ GeV, and $\varepsilon^2$ ranging between $10^{-11}$ and $10^{-17}$.

Published
2020
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164. Destruction of eccentric planetesimals by ram pressure and erosion

Author

Demirci, Tunahan, Schneider, Niclas, Teiser, Jens, and Wurm, Gerhard

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Small, pebble-sized objects and large bodies of planetesimal size both play important roles in planet formation. They form the evolutionary steps of dust growth in their own respect. However, at later times, they are also thought to provide background populations of mass that larger bodies might feed upon. What we suggest in this work is that starting at times of viscous stirring, planetesimals on eccentric orbits could simply explode as they become supersonic in comparison to small, porous planetary bodies entering Earth's atmosphere. We present a toy model of planetesimal motion and destruction to show the key aspects of this process. The consequences are quite severe. At all times, it is shown that only planetesimals on more or less circular orbits exist in the inner disk. After the destruction of a planetesimal, the remaining matter is continuously redistributed to the pebble reservoir of the protoplanetary disk. Since destruction typically occurs at small stellar distances due to supersonic speeds, it is expected to boost pebble accretion in the inner protoplanetary disk as one of its main effects.

Published
2020
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165. Cosmic radiation does not prevent collisional charging in (Pre)-Planetary Atmospheres

Author

Jungmann, Felix, Bila, Tetyana, Kleinert, Laura, Mölleken, Andre, Möller, Rolf, Schmidt, Lars, Schneider, Niclas, Teiser, Jens, Utzat, Detlef, Volkenborn, Victoria, and Wurm, Gerhard

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In (pre)-planetary environments, dust and sand grains regularly collide. They electrically charge and discharge during these events. In this work, we study if cosmic radiation has any influence on the equilibrium charge state on timescales of minutes. We developed an experiment that was carried out during the ascent of a stratospheric balloon. With increasing altitude, the radiation activity increases by a factor of 54. However, we found only a very minor decrease in grain charges of up to 30%. This implies that charge-moderated processes from thunderstorms on Earth, over early phases of planet formation to particle motion on the Martian surface on short timescales essentially proceed unhindered from a direct influence of cosmic radiation.

Published
2020
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166. Detecting the Diffuse Supernova Neutrino Background in the future Water-based Liquid Scintillator Detector Theia

Author

Sawatzki, Julia, Wurm, Michael, and Kresse, Daniel

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

A large-scale neutrino observatory based on Water-based Liquid Scintillator (WbLS) will be excellently suited for a measurement of the Diffuse Supernova Neutrino Background (DSNB). The WbLS technique offers high signal efficiency and effective suppression of the otherwise overwhelming background from neutral-current interactions of atmospheric neutrinos. To illustrate this, we investigate the DSNB sensitivity for two configurations of the future Theia detector by developing the expected signal and background rejection efficiencies along a full analysis chain. Based on a statistical analysis of the remaining signal and background rates, we find that a rather moderate exposure of 190kt$\cdot$yrs will be sufficient to claim a ($5\sigma$) discovery of the faint DSNB signal for standard model assumptions. We conclude that, in comparison with other experimental techniques, WbLS offers the highest signal efficiency of more than 80\% and best signal significance over background.

Published
2020
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167. Accretion of eroding pebbles and planetesimals in planetary envelopes

Author

Demirci, Tunahan and Wurm, Gerhard

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Wind erosion is a destructive mechanism that completely dissolves a weakly bound object like a planetesimal into its constituent particles, if the velocity relative to the ambient gas and the local gas pressure are sufficiently high. In numerical simulations we study the influence of such wind erosion on pebble and planetesimal accretion by a planetary body up to $10 R_\mathrm{Earth}$. Due to the rapid size reduction of an in-falling small body, the accretion outcome changes significantly. Erosion leads to a strong decrease in the accretion efficiency below a threshold size of the small body on the order of 10 m. This slows down pebble accretion significantly for a given size distribution of small bodies. The threshold radius of the small body increases with increasing planet radius and decreases with increasing semi-major axis. Within the parameters studied, an additional planetary atmosphere (up to 1 bar) is of minor importance.

Published
2020
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168. Laboratory Impact Splash Experiments to Simulate Asteroid Surfaces

Author

Bogdan, Tabea, Kollmer, Jonathan E., Teiser, Jens, Kruss, Maximilian, and Wurm, Gerhard

Subjects
Astrophysics - Earth and Planetary Astrophysics, Condensed Matter - Soft Condensed Matter
Abstract

Granular material that is bound by the low gravity of a small asteroid is mobilized by slow velocity impacts. These splashes generated by impacts might play an important role in sculpting the asteroid's surface. In laboratory experiments we characterize the ejecta generated by spherical 150 $\rm \mu m$ diameter basalt grains impacting a granular bed at 0.8 m/s. We find that such an impact typically leads to less than 10 particles being ejected from the granular bed, with typical ejecta trajectories rising to less than one particle diameter above the surface. That is, the observed impacts are highly dissipative and only a small fraction of the impact energy is imparted onto the ejecta. While the impactor itself still rebounds, it typically slows down significantly to an average of about 20 % of its impact velocity. Scaled to asteroids, impactor and ejecta generated from impacts of sand sized grains are not able to spread over the asteroid's surface but will stay close to the impact site. Therefore these highly inelastic impacts into soft granular beds efficiently trap grains, in contrast to more elastic impacts on bare, rocky surfaces confirming suggestions by Shinbrot (2017). This is also in agreement to observed features on asteroids as this topological elasticity bias suggests that redistribution of grains leads to a size segregation.

Published
2020
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169. Drifting inwards in protoplanetary discs I Sticking of chondritic dust at increasing temperatures

Author

Bogdan, T., Pillich, C., Landers, J., Wende, H., and Wurm, G.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Sticking properties rule the early phases of pebble growth in protoplanetary discs in which grains regularly travel from cold, water-rich regions to the warm inner part. This drift affects composition, grain size, morphology, and water content as grains experience ever higher temperatures. In this study we tempered chondritic dust under vacuum up to 1400 K. Afterwards, we measured the splitting tensile strength of millimetre-sized dust aggregates. The deduced effective surface energy starts out as $\gamma_e = 0.07\,\rm J/m^2$. This value is dominated by abundant iron-oxides as measured by M\"ossbauer spectroscopy. Up to 1250 K, $\gamma_e$ continuously decreases by up to a factor five. Olivines dominate at higher temperature. Beyond 1300 K dust grains significantly grow in size. The $\gamma_e$ no longer decreases but the large grain size restricts the capability of growing aggregates. Beyond 1400 K aggregation is no longer possible. Overall, under the conditions probed, the stability of dust pebbles would decrease towards the star. In view of a minimum aggregate size required to trigger drag instabilities it becomes increasingly harder to seed planetesimal formation closer to a star.

Published
2020
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170. Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector

Author

Bay, Daya, collaborations, JUNO, Abusleme, A., Adam, T., Ahmad, S., Aiello, S., Akram, M., Ali, N., An, F. P., An, G. P., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., de André, J. P. A. M., Babic, A., Balantekin, A. B., Baldini, W., Baldoncini, M., Band, H. R., Barresi, A., Baussan, E., Bellato, M., Bernieri, E., Biare, D., Birkenfeld, T., Bishai, M., Blin, S., Blum, D., Blyth, S., Bordereau, C., Brigatti, A., Brugnera, R., Budano, A., Burgbacher, P., Buscemi, M., Bussino, S., Busto, J., Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y. K., Cai, Z. Y., Cammi, A., Campeny, A., Cao, C. Y., Cao, G. F., Cao, J., Caruso, R., Cerna, C., Chakaberia, I., Chang, J. F., Chang, Y., Chen, H. S., Chen, P. A., Chen, P. P., Chen, S. M., Chen, S. J., Chen, X. R., Chen, Y. W., Chen, Y. X., Chen, Y., Chen, Z., Cheng, J., Cheng, Y. P., Cheng, Z. K., Chepurnov, A., Cherwinka, J. J., Chiarello, F., Chiesa, D., Chimenti, P., Chu, M. C., Chukanov, A., Chuvashova, A., Clementi, ., Clerbaux, B., Di Lorenzo, S. Conforti, Corti, D., Costa, S., Corso, F. D., Cummings, J. P., Dalager, O., De La Taille, C., Deng, F. S., Deng, J. W., Deng, Z., Deng, Z. Y., Depnering, W., Diaz, M., Ding, X. F., Ding, Y. Y., Dirgantara, B., Dmitrievsky, S., Diwan, M. V., Dohnal, T., Donchenko, G., Dong, J. M., Dornic, D., Doroshkevich, E., Dove, J., Dracos, M., Druillole, F., Du, S. X., Dusini, S., Dvorak, M., Dwyer, D. A., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D. H., Fan, L., Fang, C., Fang, J., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. C., Feng, Q. C., Fiorentini, G., Ford, R., Formozov, A., Fournier, A., Franke, S., Gallo, J. P., Gan, H. N., Gao, F., Garfagnini, A., Göttel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Giuliani, F., Gonchar, M., Gong, G. H., Gong, H., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, M., Gromov, V., Gu, M. H., Gu, W. Q., Gu, X. F., Gu, Y., Guan, M. Y., Guardone, N., Gul, M., Guo, C., Guo, J. Y., Guo, L., Guo, W. L., Guo, X. H., Guo, Y. H., Guo, Z., Haacke, M., Hackenburg, R. W., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hans, S., He, M., He, W., Heeger, K. M., Heinz, T., Heng, Y. K., Herrera, R., Higuera, A., Hong, D. J., Hor, Y. K., Hou, S. J., Hsiung, Y. B., Hu, B. Z., Hu, H., Hu, J. R., Hu, J., Hu, S. Y., Hu, T., Hu, Z. J., Huang, C. H., Huang, G. H., Huang, H. X., Huang, Q. H., Huang, W. H., Huang, X. T., Huang, Y. B., Huber, P., Hui, J. Q., Huo, L., Huo, W. J., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Ioannisyan, D., Isocrate, R., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Ji, X. Z., Jia, H. H., Jia, J. J., Jian, S. Y., Jiang, D., Jiang, X. S., Jin, R. Y., Jing, X. P., Johnson, R. A., Jollet, C., Jones, D., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Kang, L., Karagounis, M., Kazarian, N., Kettell, S. H., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Kohn, S., Korablev, D., Kouzakov, K., Kramer, M., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachacinski, B., Lachenmaier, T., Langford, T. J., Lee, J., Lee, J. H. C., Lefevre, F., Lei, L., Lei, R., Leitner, R., Leung, J., Li, C., Li, D. M., Li, F., Li, H. T., Li, H. L., Li, J., Li, J. J., Li, J. Q., Li, K. J., Li, M. Z., Li, N., Li, Q. J., Li, R. H., Li, S. C., Li, S. F., Li, S. J., Li, T., Li, W. D., Li, W. G., Li, X. M., Li, X. N., Li, X. L., Li, X. Q., Li, Y., Li, Y. F., Li, Z. B., Li, Z. Y., Liang, H., Liang, J. J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, C. J., Lin, G. L., Lin, S. X., Lin, T., Lin, Y. H., Ling, J. J., Link, J. M., Lippi, I., Littenberg, L., Littlejohn, B. R., Liu, F., Liu, H., Liu, H. B., Liu, H. D., Liu, H. J., Liu, H. T., Liu, J. C., Liu, J. L., Liu, M., Liu, Q., Liu, R. X., Liu, S. Y., Liu, S. B., Liu, S. L., Liu, X. W., Liu, Y., Lokhov, A., Lombardi, P., Loo, K., Lorenz, S., Lu, C., Lu, H. Q., Lu, J. B., Lu, J. G., Lu, S. X., Lu, X. X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luk, K. B., Luo, F. J., Luo, G., Luo, P. W., Luo, S., Luo, W. M., Lyashuk, V., Ma, Q. M., Ma, S., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., Mantovani, F., Mao, Y. J., Mari, S. M., Marini, F., Marium, S., Marshall, C., Martellini, C., Martin-Chassard, G., Caicedo, D. A. Martinez, Martini, A., Martino, J., Mayilyan, D., McDonald, K. T., McKeown, R. D., Müller, A., Meng, G., Meng, Y., Meregaglia, A., Meroni, E., Meyhöfer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muralidharan, P., Napolitano, J., Nastasi, M., Naumov, D. V., Naumova, E., Nemchenok, I., Nikolaev, A., Ning, F. P., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H. R., Paoloni, A., Park, J., Parkalian, N., Parmeggiano, S., Patton, S., Payupol, T., Pec, V., Pedretti, D., Pei, Y. T., Pelliccia, N., Peng, A. G., Peng, H. P., Peng, J. C., Perrot, F., Petitjean, P. A., Rico, L. F. Pineres, Popov, A., Poussot, P., Pratumwan, W., Previtali, E., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, S., Qian, X., Qian, X. H., Qiao, H., Qin, Z. H., Qiu, S. K., Rajput, M., Ranucci, G., Raper, N., Re, A., Rebber, H., Rebii, A., Ren, B., Ren, J., Reveco, C. M., Rezinko, T., Ricci, B., Robens, M., Roche, M., Rodphai, N., Rohwer, L., Romani, A., Rosero, R., Roskovec, B., Roth, C., Ruan, X. C., Ruan, X. D., Rujirawat, S., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sangka, A., Sanguansak, N., Sawangwit, U., Sawatzki, J., Sawy, F., Schever, M., Schuler, J., Schwab, C., Schweizer, K., Selivanov, D., Selyunin, A., Serafini, A., Settanta, G., Settimo, M., Shahzad, M., Shi, G., Shi, J. Y., Shi, Y. J., Shutov, V., Sidorenkov, A., Simkovic, F., Sirignano, C., Siripak, J., Sisti, M., Slupecki, M., Smirnov, M., Smirnov, O., Sogo-Bezerra, T., Songwadhana, J., Soonthornthum, B., Sotnikov, A., Sramek, O., Sreethawong, W., Stahl, A., Stanco, L., Stankevich, K., Stefanik, D., Steiger, H., Steiner, H., Steinmann, J., Stender, M., Strati, V., Studenikin, A., Sun, G. X., Sun, L. T., Sun, J. L., Sun, S. F., Sun, X. L., Sun, Y. J., Sun, Y. Z., Suwonjandee, N., Szelezniak, M., Tang, J., Tang, Q., Tang, X., Tietzsch, A., Tkachev, I., Tmej, T., Treskov, K., Troni, G., Trzaska, W., Tse, W. -H., Tull, C. E., Tuve, C., van Waasen, S., Boom, J. Vanden, Vassilopoulos, N., Vedin, V., Verde, G., Vialkov, M., Viaud, B., Viren, B., Volpe, C., Vorobel, V., Votano, L., Walker, P., Wang, C., Wang, C. H., Wang, E., Wang, G. L., Wang, J., Wang, K. Y., Wang, L., Wang, M. F., Wang, M., Wang, N. Y., Wang, R. G., Wang, S. G., Wang, W., Wang, W. S., Wang, X., Wang, X. Y., Wang, Y., Wang, Y. F., Wang, Y. G., Wang, Y. M., Wang, Y. Q., Wang, Z., Wang, Z. M., Wang, Z. Y., Watcharangkool, A., Wei, H. Y., Wei, L. H., Wei, W., Wei, Y. D., Wen, L. J., Whisnant, K., White, C. G., Wiebusch, C., Wong, S. C. F., Wong, H. L. H., Wonsak, B., Worcester, E., Wu, C. H., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Wu, Z., Wurm, M., Wurtz, J., Wysotzki, C., Xi, Y. F., Xia, D. M., Xie, Y. G., Xie, Z. Q., Xing, Z. Z., Xu, D. L., Xu, F. R., Xu, H. K., Xu, J. L., Xu, J., Xu, M. H., Xu, T., Xu, Y., Xue, T., Yan, B. J., Yan, X. B., Yan, Y. P., Yang, A. B., Yang, C. G., Yang, H., Yang, J., Yang, L., Yang, X. Y., Yang, Y. F., Yang, Y. Z., Yao, H. F., Yasin, Z., Ye, J. X., Ye, M., Yegin, U., Yeh, M., Yermia, F., Yi, P. H., You, Z. Y., Young, B. L., Yu, B. X., Yu, C. X., Yu, C. Y., Yu, H. Z., Yu, M., Yu, X. H., Yu, Z. Y., Yuan, C. Z., Yuan, Y., Yuan, Z. X., Yuan, Z. Y., Yue, B. B., Zafar, N., Zambanini, A., Zeng, P., Zeng, S., Zeng, T. X., Zeng, Y. D., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, G. Q., Zhang, H. H., Zhang, H. Q., Zhang, J., Zhang, J. B., Zhang, J. W., Zhang, P., Zhang, Q. M., Zhang, T., Zhang, X. M., Zhang, X. T., Zhang, Y., Zhang, Y. H., Zhang, Y. M., Zhang, Y. P., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, F. Y., Zhao, J., Zhao, R., Zhao, S. J., Zhao, T. C., Zheng, D. Q., Zheng, H., Zheng, M. S., Zheng, Y. H., Zhong, W. R., Zhou, J., Zhou, L., Zhou, N., Zhou, S., Zhou, X., Zhu, J., Zhu, K. J., Zhuang, H. L., Zong, L., and Zou, J. H.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and <0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. To bridge the one order of magnitude in the detector size difference between Daya Bay and JUNO, the Daya Bay data were used to tune the parameters of a newly developed optical model. Then, the model and tuned parameters were used in the JUNO simulation. This enabled to determine the optimal composition for the JUNO LS: purified solvent LAB with 2.5 g/L PPO, and 1 to 4 mg/L bis-MSB., Comment: 13 pages, 8 figures

Published
2020

171. Experimental evidence of neutrinos produced in the CNO fusion cycle in the Sun

Author

Agostini, M., Altenmüller, K., Appel, S., Atroshchenko, V., Bagdasarian, Z., Basilico, D., Bellini, G., Benziger, J., Biondi, R., Bravo, D., Caccianiga, B., Calaprice, F., Caminata, A., Cavalcante, P., Chepurnov, A., D'Angelo, D., Davini, S., Derbin, A., Di Giacinto, A., Di Marcello, V., Ding, X. F., Di Ludovico, A., Di Noto, L., Drachnev, I., Formozov, A., Franco, D., Galbiati, C., Ghiano, C., Giammarchi, M., Goretti, A., Göttel, A. S., Gromov, M., Guffanti, D., Ianni, Aldo, Ianni, Andrea, Jany, A., Jeschke, D., Kobychev, V., Korga, G., Kumaran, S., Laubenstein, M., Litvinovich, E., Lombardi, P., Lomskaya, I., Ludhova, L., Lukyanchenko, G., Lukyanchenko, L., Machulin, I., Martyn, J., Meroni, E., Meyer, M., Miramonti, L., Misiaszek, M., Muratova, V., Neumair, B., Nieslony, M., Nugmanov, R., Oberauer, L., Orekhov, V., Ortica, F., Pallavicini, M., Papp, L., Pellicci, L., Penek, Ö., Pietrofaccia, L., Pilipenko, N., Pocar, A., Raikov, G., Ranalli, M. T., Ranucci, G., Razeto, A., Re, A., Redchuk, M., Romani, A., Rossi, N., Schönert, S., Semenov, D., Settanta, G., Skorokhvatov, M., Singhal, A., Smirnov, O., Sotnikov, A., Suvorov, Y., Tartaglia, R., Testera, G., Thurn, J., Unzhakov, E., Villante, F. L., Vishneva, A., Vogelaar, R. B., von Feilitzsch, F., Wojcik, M., Wurm, M., Zavatarelli, S., Zuber, K., and Collaboration, G. Zuzel. The BOREXINO

Subjects
High Energy Physics - Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Instrumentation and Detectors, G.3.1
Abstract

For most of their existence stars are fueled by the fusion of hydrogen into helium proceeding via two theoretically well understood processes, namely the $pp$ chain and the CNO cycle. Neutrinos emitted along such fusion processes in the solar core are the only direct probe of the deep interior of the star. A complete spectroscopy of neutrinos from the {\it pp} chain, producing about 99\% of the solar energy, has already been performed \cite{bib:Nature-2018}. Here, we report the direct observation, with a high statistical significance, of neutrinos produced in the CNO cycle in the Sun. This is the first experimental evidence of this process obtained with the unprecedentedly radio-pure large-volume liquid-scintillator Borexino detector located at the underground Laboratori Nazionali del Gran Sasso in Italy. The main difficulty of this experimental effort is to identify the excess of the few counts per day per 100 tonnes of target due to CNO neutrino interactions above the backgrounds. A novel method to constrain the rate of \bi contaminating the scintillator relies on the thermal stabilisation of the detector achieved over the past 5 years. In the CNO cycle, the hydrogen fusion is catalyzed by the carbon (C) - nitrogen (N) - oxygen (O) and thus its rate, as well as the flux of emitted CNO neutrinos, directly depends on the abundance of these elements in solar core. Therefore, this result paves the way to a direct measurement of the solar metallicity by CNO neutrinos. While this result quantifies the relative contribution of the CNO fusion in the Sun to be of the order of 1\%, this process is dominant in the energy production of massive stars. The occurrence of the primary mechanism for the stellar conversion of hydrogen into helium in the Universe has been proven., Comment: 43 pages, 14 figures

Published
2020
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172. Composition and Size Dependent Sorting in Preplanetary Growth: Seeding the Formation of Mercury-like Planets

Author

Kruss, Maximilian and Wurm, Gerhard

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In an earlier work, we found that large metallic iron fractions in dust aggregates and strong magnetic fields boost preplanetary growth. This sets an initial bias for the formation of Mercury-like planets in the inner part of protoplanetary disks. We extended these experiments here by adding pure quartz aggregates to the iron-rich aggregates. Magnetic boost still leads to the formation of larger clusters of aggregates. These clusters now include silicate aggregates, which can also be connecting bridges between chains. However, at least a certain fraction of iron-rich aggregates are needed to trigger magnetic boost. Without a magnetic field, the sticking properties of the aggregates and their constituents determine the composition of clusters of a given size. This introduces a new fractionation and sorting mechanism by cluster formation at the bouncing barrier.

Published
2020
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173. Feasibility and physics potential of detecting $^8$B solar neutrinos at JUNO

Author

JUNO collaboration, Abusleme, Angel, Adam, Thomas, Ahmad, Shakeel, Aiello, Sebastiano, Akram, Muhammad, Ali, Nawab, An, Fengpeng, An, Guangpeng, An, Qi, Andronico, Giuseppe, Anfimov, Nikolay, Antonelli, Vito, Antoshkina, Tatiana, Asavapibhop, Burin, de André, João Pedro Athayde Marcondes, Auguste, Didier, Babic, Andrej, Baldini, Wander, Barresi, Andrea, Baussan, Eric, Bellato, Marco, Bergnoli, Antonio, Bernieri, Enrico, Biare, David, Birkenfeld, Thilo, Blin, Sylvie, Blum, David, Blyth, Simon, Bolshakova, Anastasia, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Brigatti, Augusto, Brugnera, Riccardo, Bruno, Riccardo, Budano, Antonio, Buesken, Max, Buscemi, Mario, Busto, Jose, Butorov, Ilya, Cabrera, Anatael, Cai, Hao, Cai, Xiao, Cai, Yanke, Cai, Zhiyan, Cammi, Antonio, Campeny, Agustin, Cao, Chuanya, Cao, Guofu, Cao, Jun, Caruso, Rossella, Cerna, Cédric, Chakaberia, Irakli, Chang, Jinfan, Chang, Yun, Chen, Pingping, Chen, Po-An, Chen, Shaomin, Chen, Shenjian, Chen, Xurong, Chen, Yi-Wen, Chen, Yixue, Chen, Yu, Chen, Zhang, Cheng, Jie, Cheng, Yaping, Chepurnov, Alexander, Chiesa, Davide, Chimenti, Pietro, Chukanov, Artem, Chuvashova, Anna, Claverie, Gérard, Clementi, Catia, Clerbaux, Barbara, Di Lorenzo, Selma Conforti, Corti, Daniele, Costa, Salvatore, Corso, Flavio Dal, De La Taille, Christophe, Deng, Jiawei, Deng, Zhi, Deng, Ziyan, Depnering, Wilfried, Diaz, Marco, Ding, Xuefeng, Ding, Yayun, Dirgantara, Bayu, Dmitrievsky, Sergey, Dohnal, Tadeas, Donchenko, Georgy, Dong, Jianmeng, Dornic, Damien, Doroshkevich, Evgeny, Dracos, Marcos, Druillole, Frédéric, Du, Shuxian, Dusini, Stefano, Dvorak, Martin, Enqvist, Timo, Enzmann, Heike, Fabbri, Andrea, Fajt, Lukas, Fan, Donghua, Fan, Lei, Fang, Can, Fang, Jian, Fargetta, Marco, Fatkina, Anna, Fedoseev, Dmitry, Fekete, Vladko, Feng, Li-Cheng, Feng, Qichun, Ford, Richard, Formozov, Andrey, Fournier, Amélie, Gan, Haonan, Gao, Feng, Garfagnini, Alberto, Göttel, Alexandre, Genster, Christoph, Giammarchi, Marco, Giaz, Agnese, Giudice, Nunzio, Giuliani, Franco, Gonchar, Maxim, Gong, Guanghua, Gong, Hui, Gorchakov, Oleg, Gornushkin, Yuri, Grassi, Marco, Grewing, Christian, Gromov, Maxim, Gromov, Vasily, Gu, Minghao, Gu, Xiaofei, Gu, Yu, Guan, Mengyun, Guardone, Nunzio, Gul, Maria, Guo, Cong, Guo, Jingyuan, Guo, Wanlei, Guo, Xinheng, Guo, Yuhang, Hackspacher, Paul, Hagner, Caren, Han, Ran, Han, Yang, He, Miao, He, Wei, Heinz, Tobias, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hong, Daojin, Hou, Shaojing, Hsiung, Yee, Hu, Bei-Zhen, Hu, Hang, Hu, Jianrun, Hu, Jun, Hu, Shouyang, Hu, Tao, Hu, Zhuojun, Huang, Chunhao, Huang, Guihong, Huang, Hanxiong, Huang, Qinhua, Huang, Wenhao, Huang, Xingtao, Huang, Yongbo, Hui, Jiaqi, Huo, Lei, Huo, Wenju, Huss, Cédric, Hussain, Safeer, Insolia, Antonio, Ioannisian, Ara, Isocrate, Roberto, Jen, Kuo-Lun, Ji, Xiaolu, Ji, Xingzhao, Jia, Huihui, Jia, Junji, Jian, Siyu, Jiang, Di, Jiang, Xiaoshan, Jin, Ruyi, Jing, Xiaoping, Jollet, Cécile, Joutsenvaara, Jari, Jungthawan, Sirichok, Kalousis, Leonidas, Kampmann, Philipp, Kang, Li, Karagounis, Michael, Kazarian, Narine, Khan, Amir, Khan, Waseem, Khosonthongkee, Khanchai, Kinz, Patrick, Korablev, Denis, Kouzakov, Konstantin, Krasnoperov, Alexey, Krokhaleva, Svetlana, Krumshteyn, Zinovy, Kruth, Andre, Kutovskiy, Nikolay, Kuusiniemi, Pasi, Lachenmaier, Tobias, Landini, Cecilia, Leblanc, Sébastien, Lefevre, Frederic, Lei, Liping, Lei, Ruiting, Leitner, Rupert, Leung, Jason, Li, Chao, Li, Demin, Li, Fei, Li, Fule, Li, Haitao, Li, Huiling, Li, Jiaqi, Li, Jin, Li, Kaijie, Li, Mengzhao, Li, Nan, Li, Qingjiang, Li, Ruhui, Li, Shanfeng, Li, Shuaijie, Li, Tao, Li, Teng, Li, Weidong, Li, Weiguo, Li, Xiaomei, Li, Xiaonan, Li, Xinglong, Li, Yi, Li, Yufeng, Li, Zhibing, Li, Ziyuan, Liang, Hao, Liang, Jingjing, Liebau, Daniel, Limphirat, Ayut, Limpijumnong, Sukit, Lin, Guey-Lin, Lin, Shengxin, Lin, Tao, Ling, Jiajie, Lippi, Ivano, Liu, Fang, Liu, Haidong, Liu, Hongbang, Liu, Hongjuan, Liu, Hongtao, Liu, Hu, Liu, Hui, Liu, Jianglai, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shuangyu, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Yan, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Shuxiang, Lu, Xiaoxu, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Luo, Fengjiao, Luo, Guang, Luo, Pengwei, Luo, Shu, Luo, Wuming, Lyashuk, Vladimir, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Malyshkin, Yury, Mantovani, Fabio, Manzali, Francesco, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Marium, Sadia, Martellini, Cristina, Martin-Chassard, Gisele, Martini, Agnese, Mayilyan, Davit, Müller, Axel, Meng, Yue, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Mezzetto, Mauro, Miller, Jonathan, Miramonti, Lino, Monforte, Salvatore, Montini, Paolo, Montuschi, Michele, Morozov, Nikolay, Muralidharan, Pavithra, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Nemchenok, Igor, Nikolaev, Alexey, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Pan, Hsiao-Ru, Paoloni, Alessandro, Parkalian, Nina, Parmeggiano, Sergio, Payupol, Teerapat, Pei, Yatian, Pelliccia, Nicomede, Peng, Anguo, Peng, Haiping, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Rico, Luis Felipe Piñeres, Pilarczyk, Oliver, Popov, Artyom, Poussot, Pascal, Pratumwan, Wathan, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qian, Sen, Qian, Xiaohui, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Rajput, Muhammad, Ranucci, Gioacchino, Raper, Neill, Re, Alessandra, Rebber, Henning, Rebii, Abdel, Ren, Bin, Ren, Jie, Rezinko, Taras, Ricci, Barbara, Robens, Markus, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Roth, Christian, Ruan, Xiangdong, Ruan, Xichao, Rujirawat, Saroj, Rybnikov, Arseniy, Sadovsky, Andrey, Saggese, Paolo, Salamanna, Giuseppe, Sanfilippo, Simone, Sangka, Anut, Sanguansak, Nuanwan, Sawangwit, Utane, Sawatzki, Julia, Sawy, Fatma, Schever, Michaela, Schuler, Jacky, Schwab, Cédric, Schweizer, Konstantin, Selivanov, Dmitry, Selyunin, Alexandr, Serafini, Andrea, Settanta, Giulio, Settimo, Mariangela, Shahzad, Muhammad, Sharov, Vladislav, Shi, Gang, Shi, Jingyan, Shi, Yongjiu, Shutov, Vitaly, Sidorenkov, Andrey, Simkovic, Fedor, Sirignano, Chiara, Siripak, Jaruchit, Sisti, Monica, Slupecki, Maciej, Smirnov, Mikhail, Smirnov, Oleg, Sogo-Bezerra, Thiago, Songwadhana, Julanan, Soonthornthum, Boonrucksar, Sotnikov, Albert, Sramek, Ondrej, Sreethawong, Warintorn, Stahl, Achim, Stanco, Luca, Stankevich, Konstantin, Stefanik, Dus, Steiger, Hans, Steinmann, Jochen, Sterr, Tobias, Stock, Matthias Raphael, Strati, Virginia, Studenikin, Alexander, Sun, Gongxing, Sun, Shifeng, Sun, Xilei, Sun, Yongjie, Sun, Yongzhao, Suwonjandee, Narumon, Szelezniak, Michal, Tang, Jian, Tang, Qiang, Tang, Quan, Tang, Xiao, Tietzsch, Alexander, Tkachev, Igor, Tmej, Tomas, Treskov, Konstantin, Triossi, Andrea, Troni, Giancarlo, Trzaska, Wladyslaw, Tuve, Cristina, van Waasen, Stefan, Boom, Johannes Vanden, Vanroyen, Guillaume, Vassilopoulos, Nikolaos, Vedin, Vadim, Verde, Giuseppe, Vialkov, Maxim, Viaud, Benoit, Volpe, Cristina, Vorobel, Vit, Votano, Lucia, Walker, Pablo, Wang, Caishen, Wang, Chung-Hsiang, Wang, En, Wang, Guoli, Wang, Jian, Wang, Jun, Wang, Kunyu, Wang, Lu, Wang, Meifen, Wang, Meng, Wang, Ruiguang, Wang, Siguang, Wang, Wei, Wang, Wenshuai, Wang, Xi, Wang, Xiangyue, Wang, Yangfu, Wang, Yaoguang, Wang, Yi, Wang, Yifang, Wang, Yuanqing, Wang, Yuman, Wang, Zhe, Wang, Zheng, Wang, Zhimin, Wang, Zongyi, Watcharangkool, Apimook, Wei, Lianghong, Wei, Wei, Wei, Yadong, Wen, Liangjian, Wiebusch, Christopher, Wong, Steven Chan-Fai, Wonsak, Bjoern, Wu, Diru, Wu, Fangliang, Wu, Qun, Wu, Wenjie, Wu, Zhi, Wurm, Michael, Wurtz, Jacques, Wysotzki, Christian, Xi, Yufei, Xia, Dongmei, Xie, Yuguang, Xie, Zhangquan, Xing, Zhizhong, Xu, Benda, Xu, Donglian, Xu, Fanrong, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Xiongbo, Yan, Yupeng, Yang, Anbo, Yang, Changgen, Yang, Huan, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yao, Haifeng, Yasin, Zafar, Ye, Jiaxuan, Ye, Mei, Yegin, Ugur, Yermia, Frédéric, Yi, Peihuai, Yin, Xiangwei, You, Zhengyun, Yu, Boxiang, Yu, Chiye, Yu, Chunxu, Yu, Hongzhao, Yu, Miao, Yu, Xianghui, Yu, Zeyuan, Yuan, Chengzhuo, Yuan, Ying, Yuan, Zhenxiong, Yuan, Ziyi, Yue, Baobiao, Zafar, Noman, Zambanini, Andre, Zeng, Pan, Zeng, Shan, Zeng, Tingxuan, Zeng, Yuda, Zhan, Liang, Zhang, Feiyang, Zhang, Guoqing, Zhang, Haiqiong, Zhang, Honghao, Zhang, Jiawen, Zhang, Jie, Zhang, Jingbo, Zhang, Peng, Zhang, Qingmin, Zhang, Shiqi, Zhang, Tao, Zhang, Xiaomei, Zhang, Xuantong, Zhang, Yan, Zhang, Yinhong, Zhang, Yiyu, Zhang, Yongpeng, Zhang, Yuanyuan, Zhang, Yumei, Zhang, Zhenyu, Zhang, Zhijian, Zhao, Fengyi, Zhao, Jie, Zhao, Rong, Zhao, Shujun, Zhao, Tianchi, Zheng, Dongqin, Zheng, Hua, Zheng, Minshan, Zheng, Yangheng, Zhong, Weirong, Zhou, Jing, Zhou, Li, Zhou, Nan, Zhou, Shun, Zhou, Xiang, Zhu, Jiang, Zhu, Kejun, Zhuang, Honglin, Zong, Liang, and Zou, Jiaheng

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

The Jiangmen Underground Neutrino Observatory~(JUNO) features a 20~kt multi-purpose underground liquid scintillator sphere as its main detector. Some of JUNO's features make it an excellent experiment for $^8$B solar neutrino measurements, such as its low-energy threshold, its high energy resolution compared to water Cherenkov detectors, and its much large target mass compared to previous liquid scintillator detectors. In this paper we present a comprehensive assessment of JUNO's potential for detecting $^8$B solar neutrinos via the neutrino-electron elastic scattering process. A reduced 2~MeV threshold on the recoil electron energy is found to be achievable assuming the intrinsic radioactive background $^{238}$U and $^{232}$Th in the liquid scintillator can be controlled to 10$^{-17}$~g/g. With ten years of data taking, about 60,000 signal and 30,000 background events are expected. This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter, which will shed new light on the tension between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework. If $\Delta m^{2}_{21}=4.8\times10^{-5}~(7.5\times10^{-5})$~eV$^{2}$, JUNO can provide evidence of neutrino oscillation in the Earth at the about 3$\sigma$~(2$\sigma$) level by measuring the non-zero signal rate variation with respect to the solar zenith angle. Moveover, JUNO can simultaneously measure $\Delta m^2_{21}$ using $^8$B solar neutrinos to a precision of 20\% or better depending on the central value and to sub-percent precision using reactor antineutrinos. A comparison of these two measurements from the same detector will help elucidate the current tension between the value of $\Delta m^2_{21}$ reported by solar neutrino experiments and the KamLAND experiment., Comment: 29 pages, 14 plots, 7 tables

Published
2020

174. Solar Neutrino Detection Sensitivity in DARWIN via Electron Scattering

Author

Aalbers, J., Agostini, F., Maouloud, S. E. M. Ahmed, Alfonsi, M., Althueser, L., Amaro, F., Angevaare, J., Antochi, V. C., Antunovic, B., Aprile, E., Arazi, L., Arneodo, F., Balzer, M., Baudis, L., Baur, D., Benabderrahmane, M. L., Biondi, Y., Bismark, A., Bourgeois, C., Breskin, A., Breur, P. A., Brown, A., Brown, E., Brünner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., Decowski, M. P., Depoian, A., Dierle, J., Di Gangi, P., Di Giovanni, A., Diglio, S., Douillet, D., Drexlin, G., Eitel, K., Engel, R., Erdal, E., Ferella, A. D., Fischer, H., Fischer, P., Fulgione, W., Gaemers, P., Galloway, M., Gao, F., Giovagnoli, D., Girard, F., Glade-Beucke, R., Glück, F., Grandi, L., Grohmann, S., Größle, R., Gumbsheimer, R., Hannen, V., Hansmann-Menzemer, S., Hils, C., Holzapfel, B., Howlett, J., Iaquaniello, G., Jörg, F., Keller, M., Kellerer, J., Khundzakishvili, G., Kilminster, B., Kleifges, M., Kleiner, T. K., Koltmann, G., Kopec, A., Kopmann, A., Krauss, L. M., Kuger, F., LaCascio, L., Landsman, H., Lang, R. F., Lindemann, S., Lindner, M., Lombardi, F., Lopes, J. A. M., Villalpando, A. Loya, Ma, Y., Macolino, C., Mahlstedt, J., Manfredini, A., Undagoitia, T. Marrodán, Masbou, J., Masson, D., Masson, E., McFadden, N., Meinhardt, P., Meyer, R., Milosevic, B., Milutinovic, S., Molinario, A., Monteiro, C. M. B., Morå, K., Morteau, E., Mosbacher, Y., Murra, M., Newstead, J. L., Ni, K., Oberlack, U. G., Obradovic, M., Odgers, K., Ostrovskiy, I., Palacio, J., Pandurovic, M., Pelssers, B., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S. E., Rupp, N., Sanchez-Lucas, P., Santos, J., Sartorelli, G., Schulte, D., Schultz-Coulon, H. -C., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Shagin, P., Sharma, S., Shen, W., Silva, M., Simgen, H., Steidl, M., Stern, S., Subotic, D., Szabo, P., Terliuk, A., Therreau, C., Thers, D., Thieme, K., Toennies, F., Trotta, R., Tunnell, C. D., Valerius, K., Volta, G., Vorkapic, D., Weber, M., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, J., Wuestling, S., Wurm, M., Xing, Y., Zhu, T., Zhu, Y., Zopounidis, J. P., and Zuber, K.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We detail the sensitivity of the liquid xenon (LXe) DARWIN observatory to solar neutrinos via elastic electron scattering. We find that DARWIN will have the potential to measure the fluxes of five solar neutrino components: $pp$, $^7$Be, $^{13}$N, $^{15}$O and $pep$. The precision of the $^{13}$N, $^{15}$O and $pep$ components is hindered by the double-beta decay of $^{136}$Xe and, thus, would benefit from a depleted target. A high-statistics observation of $pp$ neutrinos would allow us to infer the values of the weak mixing angle, $\sin^2\theta_w$, and the electron-type neutrino survival probability, $P_e$, in the electron recoil energy region from a few keV up to 200 keV for the first time, with relative precision of 5% and 4%, respectively, at an exposure of 300 ty. An observation of $pp$ and $^7$Be neutrinos would constrain the neutrino-inferred solar luminosity down to 0.2%. A combination of all flux measurements would distinguish between the high (GS98) and low metallicity (AGS09) solar models with 2.1-2.5$\sigma$ significance, independent of external measurements from other experiments or a measurement of $^8$B neutrinos through coherent elastic neutrino-nucleus scattering in DARWIN. Finally, we demonstrate that with a depleted target DARWIN may be sensitive to the neutrino capture process of $^{131}$Xe., Comment: 9 pages, 4 figures; for associated data files, see https://github.com/Physik-Institut-UZH/DARWIN-Sensitivity-Studies/tree/master/solar_neutrinos_electron_scattering

Published
2020

175. Sensitivity to neutrinos from the solar CNO cycle in Borexino

Author

Agostini, M., Altenmüller, K., Appel, S., Atroshchenko, V., Bagdasarian, Z., Basilico, D., Bellini, G., Benziger, J., Biondi, R., Bravo, D., Caccianiga, B., Calaprice, F., Caminata, A., Cavalcante, P., Chepurnov, A., D'Angelo, D., Davini, S., Derbin, A., Di Giacinto, A., Di Marcello, V., Ding, X. F., Di Ludovico, A., Di Noto, L., Drachnev, I., Formozov, A., Franco, D., Galbiati, C., Ghiano, C., Giammarchi, M., Goretti, A., Göttel, A. S., Gromov, M., Guffanti, D., Ianni, Aldo, Ianni, Andrea, Jany, A., Jeschke, D., Kobychev, V., Korga, G., Kumaran, S., Laubenstein, M., Litvinovich, E., Lombardi, P., Lomskaya, I., Ludhova, L., Lukyanchenko, G., Lukyanchenko, L., Machulin, I., Martyn, J., Meroni, E., Meyer, M., Miramonti, L., Misiaszek, M., Muratova, V., Neumair, B., Nieslony, M., Nugmanov, R., Oberauer, L., Orekhov, V., Ortica, F., Pallavicini, M., Papp, L., Penek, Ö., Pietrofaccia, L., Pilipenko, N., Pocar, A., Raikov, G., Ranalli, M. T., Ranucci, G., Razeto, A., Re, A., Redchuk, M., Romani, A., Rossi, N., Schönert, S., Semenov, D., Settanta, G., Skorokhvatov, M., Smirnov, O., Sotnikov, A., Suvorov, Y., Tartaglia, R., Testera, G., Thurn, J., Unzhakov, E., Villante, F. L., Vishneva, A., Vogelaar, R. B., von Feilitzsch, F., Wojcik, M., Wurm, M., Zavatarelli, S., Zuber, K., and Zuzel, G.

Subjects
High Energy Physics - Experiment, Astrophysics - Solar and Stellar Astrophysics, Physics - Instrumentation and Detectors
Abstract

Neutrinos emitted in the carbon, nitrogen, oxygen (CNO) fusion cycle in the Sun are a sub-dominant, yet crucial component of solar neutrinos whose flux has not been measured yet. The Borexino experiment at the Laboratori Nazionali del Gran Sasso (Italy) has a unique opportunity to detect them directly thanks to the detector's radiopurity and the precise understanding of the detector backgrounds. We discuss the sensitivity of Borexino to CNO neutrinos, which is based on the strategies we adopted to constrain the rates of the two most relevant background sources, pep neutrinos from the solar pp-chain and Bi-210 beta decays originating in the intrinsic contamination of the liquid scintillator with Pb-210. Assuming the CNO flux predicted by the high-metallicity Standard Solar Model and an exposure of 1000 daysx71.3 t, Borexino has a median sensitivity to CNO neutrino higher than 3 sigma. With the same hypothesis the expected experimental uncertainty on the CNO neutrino flux is 23%, provided the uncertainty on the independent estimate of the Bi-210 interaction rate is 1.5 cpd/100t. Finally, we evaluated the expected uncertainty of the C and N abundances and the expected discrimination significance between the high and low metallicity Standard Solar Models (HZ and LZ) with future more precise measurement of the CNO solar neutrino flux., Comment: 16 pages, 12 figures

Published
2020
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176. TAO Conceptual Design Report: A Precision Measurement of the Reactor Antineutrino Spectrum with Sub-percent Energy Resolution

Author

JUNO Collaboration, Abusleme, Angel, Adam, Thomas, Ahmad, Shakeel, Aiello, Sebastiano, Akram, Muhammad, Ali, Nawab, An, Fengpeng, An, Guangpeng, An, Qi, Andronico, Giuseppe, Anfimov, Nikolay, Antonelli, Vito, Antoshkina, Tatiana, Asavapibhop, Burin, de André, João Pedro Athayde Marcondes, Auguste, Didier, Babic, Andrej, Baldini, Wander, Barresi, Andrea, Baussan, Eric, Bellato, Marco, Bergnoli, Antonio, Bernieri, Enrico, Biare, David, Birkenfeld, Thilo, Blin, Sylvie, Blum, David, Blyth, Simon, Bolshakova, Anastasia, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Brigatti, Augusto, Brugnera, Riccardo, Budano, Antonio, Buscemi, Mario, Busto, Jose, Butorov, Ilya, Cabrera, Anatael, Cai, Hao, Cai, Xiao, Cai, Yanke, Cai, Zhiyan, Cammi, Antonio, Campeny, Agustin, Cao, Chuanya, Cao, Guofu, Cao, Jun, Caruso, Rossella, Cerna, Cédric, Chakaberia, Irakli, Chang, Jinfan, Chang, Yun, Chen, Pingping, Chen, Po-An, Chen, Shaomin, Chen, Shenjian, Chen, Xurong, Chen, Yi-Wen, Chen, Yixue, Chen, Yu, Chen, Zhang, Cheng, Jie, Cheng, Yaping, Chepurnov, Alexander, Chiesa, Davide, Chimenti, Pietro, Chukanov, Artem, Chuvashova, Anna, Claverie, Gérard, Clementi, Catia, Clerbaux, Barbara, Di Lorenzo, Selma Conforti, Corti, Daniele, Costa, Salvatore, Corso, Flavio Dal, De La Taille, Christophe, Deng, Jiawei, Deng, Zhi, Deng, Ziyan, Depnering, Wilfried, Diaz, Marco, Ding, Xuefeng, Ding, Yayun, Dirgantara, Bayu, Dmitrievsky, Sergey, Dohnal, Tadeas, Donchenko, Georgy, Dong, Jianmeng, Dornic, Damien, Doroshkevich, Evgeny, Dracos, Marcos, Druillole, Frédéric, Du, Shuxian, Dusini, Stefano, Dvorak, Martin, Enqvist, Timo, Enzmann, Heike, Fabbri, Andrea, Fajt, Lukas, Fan, Donghua, Fan, Lei, Fang, Can, Fang, Jian, Fatkina, Anna, Fedoseev, Dmitry, Fekete, Vladko, Feng, Li-Cheng, Feng, Qichun, Ford, Richard, Formozov, Andrey, Fournier, Amélie, Gan, Haonan, Gao, Feng, Garfagnini, Alberto, Göttel, Alexandre, Genster, Christoph, Giammarchi, Marco, Giaz, Agnese, Giudice, Nunzio, Giuliani, Franco, Gonchar, Maxim, Gong, Guanghua, Gong, Hui, Gorchakov, Oleg, Gornushkin, Yuri, Grassi, Marco, Grewing, Christian, Gromov, Maxim, Gromov, Vasily, Gu, Minghao, Gu, Xiaofei, Gu, Yu, Guan, Mengyun, Guardone, Nunzio, Gul, Maria, Guo, Cong, Guo, Jingyuan, Guo, Wanlei, Guo, Xinheng, Guo, Yuhang, Haacke, Michael, Hackspacher, Paul, Hagner, Caren, Han, Ran, Han, Yang, He, Miao, He, Wei, Heinz, Tobias, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hong, Daojin, Hou, Shaojing, Hsiung, Yee, Hu, Bei-Zhen, Hu, Hang, Hu, Jianrun, Hu, Jun, Hu, Shouyang, Hu, Tao, Hu, Zhuojun, Huang, Chunhao, Huang, Guihong, Huang, Hanxiong, Huang, Qinhua, Huang, Wenhao, Huang, Xingtao, Huang, Yongbo, Hui, Jiaqi, Huo, Lei, Huo, Wenju, Huss, Cédric, Hussain, Safeer, Insolia, Antonio, Ioannisian, Ara, Isocrate, Roberto, Jen, Kuo-Lun, Ji, Xiaolu, Ji, Xingzhao, Jia, Huihui, Jia, Junji, Jian, Siyu, Jiang, Di, Jiang, Xiaoshan, Jin, Ruyi, Jing, Xiaoping, Jollet, Cécile, Joutsenvaara, Jari, Jungthawan, Sirichok, Kalousis, Leonidas, Kampmann, Philipp, Kang, Li, Karagounis, Michael, Kazarian, Narine, Khan, Amir, Khan, Waseem, Khosonthongkee, Khanchai, Kinz, Patrick, Korablev, Denis, Kouzakov, Konstantin, Krasnoperov, Alexey, Krokhaleva, Svetlana, Krumshteyn, Zinovy, Kruth, Andre, Kutovskiy, Nikolay, Kuusiniemi, Pasi, Lachenmaier, Tobias, Landini, Cecilia, Leblanc, Sébastien, Lefevre, Frederic, Lei, Liping, Lei, Ruiting, Leitner, Rupert, Leung, Jason, Li, Chao, Li, Demin, Li, Fei, Li, Fule, Li, Haitao, Li, Huiling, Li, Jiaqi, Li, Jin, Li, Kaijie, Li, Mengzhao, Li, Nan, Li, Qingjiang, Li, Ruhui, Li, Shanfeng, Li, Shuaijie, Li, Tao, Li, Teng, Li, Weidong, Li, Weiguo, Li, Xiaomei, Li, Xiaonan, Li, Xinglong, Li, Yi, Li, Yufeng, Li, Zhibing, Li, Ziyuan, Liang, Hao, Liang, Jingjing, Liebau, Daniel, Limphirat, Ayut, Limpijumnong, Sukit, Lin, Guey-Lin, Lin, Shengxin, Lin, Tao, Ling, Jiajie, Lippi, Ivano, Liu, Fang, Liu, Haidong, Liu, Hongbang, Liu, Hongjuan, Liu, Hongtao, Liu, Hu, Liu, Hui, Liu, Jianglai, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shuangyu, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Yan, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Shuxiang, Lu, Xiaoxu, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Luo, Fengjiao, Luo, Guang, Luo, Pengwei, Luo, Shu, Luo, Wuming, Lyashuk, Vladimir, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Malyshkin, Yury, Mantovani, Fabio, Manzali, Francesco, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Marium, Sadia, Martellini, Cristina, Martin-Chassard, Gisele, Martini, Agnese, Mayilyan, Davit, Müller, Axel, Meng, Yue, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Mezzetto, Mauro, Miller, Jonathan, Miramonti, Lino, Monforte, Salvatore, Montini, Paolo, Montuschi, Michele, Morozov, Nikolay, Muralidharan, Pavithra, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Nemchenok, Igor, Nikolaev, Alexey, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Pan, Hsiao-Ru, Paoloni, Alessandro, Parkalian, Nina, Parmeggiano, Sergio, Payupol, Teerapat, Pei, Yatian, Pelliccia, Nicomede, Peng, Anguo, Peng, Haiping, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Rico, Luis Felipe Piñeres, Popov, Artyom, Poussot, Pascal, Pratumwan, Wathan, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qian, Sen, Qian, Xiaohui, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Rajput, Muhammad, Ranucci, Gioacchino, Raper, Neill, Re, Alessandra, Rebber, Henning, Rebii, Abdel, Ren, Bin, Ren, Jie, Rezinko, Taras, Ricci, Barbara, Robens, Markus, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Roth, Christian, Ruan, Xiangdong, Ruan, Xichao, Rujirawat, Saroj, Rybnikov, Arseniy, Sadovsky, Andrey, Saggese, Paolo, Salamanna, Giuseppe, Sanfilippo, Simone, Sangka, Anut, Sanguansak, Nuanwan, Sawangwit, Utane, Sawatzki, Julia, Sawy, Fatma, Schever, Michaela, Schuler, Jacky, Schwab, Cédric, Schweizer, Konstantin, Selivanov, Dmitry, Selyunin, Alexandr, Serafini, Andrea, Settanta, Giulio, Settimo, Mariangela, Shahzad, Muhammad, Shi, Gang, Shi, Jingyan, Shi, Yongjiu, Shutov, Vitaly, Sidorenkov, Andrey, Simkovic, Fedor, Sirignano, Chiara, Siripak, Jaruchit, Sisti, Monica, Slupecki, Maciej, Smirnov, Mikhail, Smirnov, Oleg, Sogo-Bezerra, Thiago, Songwadhana, Julanan, Soonthornthum, Boonrucksar, Sotnikov, Albert, Sramek, Ondrej, Sreethawong, Warintorn, Stahl, Achim, Stanco, Luca, Stankevich, Konstantin, Stefanik, Dus, Steiger, Hans, Steinmann, Jochen, Sterr, Tobias, Stock, Matthias Raphael, Strati, Virginia, Studenikin, Alexander, Sun, Gongxing, Sun, Shifeng, Sun, Xilei, Sun, Yongjie, Sun, Yongzhao, Suwonjandee, Narumon, Szelezniak, Michal, Tang, Jian, Tang, Qiang, Tang, Quan, Tang, Xiao, Tietzsch, Alexander, Tkachev, Igor, Tmej, Tomas, Treskov, Konstantin, Triossi, Andrea, Troni, Giancarlo, Trzaska, Wladyslaw, Tuve, Cristina, van Waasen, Stefan, Boom, Johannes Vanden, Vanroyen, Guillaume, Vassilopoulos, Nikolaos, Vedin, Vadim, Verde, Giuseppe, Vialkov, Maxim, Viaud, Benoit, Volpe, Cristina, Vorobel, Vit, Votano, Lucia, Walker, Pablo, Wang, Caishen, Wang, Chung-Hsiang, Wang, En, Wang, Guoli, Wang, Jian, Wang, Jun, Wang, Kunyu, Wang, Lu, Wang, Meifen, Wang, Meng, Wang, Ruiguang, Wang, Siguang, Wang, Wei, Wang, Wenshuai, Wang, Xi, Wang, Xiangyue, Wang, Yangfu, Wang, Yaoguang, Wang, Yi, Wang, Yifang, Wang, Yuanqing, Wang, Yuman, Wang, Zhe, Wang, Zheng, Wang, Zhimin, Wang, Zongyi, Watcharangkool, Apimook, Wei, Lianghong, Wei, Wei, Wei, Yadong, Wen, Liangjian, Wiebusch, Christopher, Wong, Steven Chan-Fai, Wonsak, Bjoern, Wu, Diru, Wu, Fangliang, Wu, Qun, Wu, Wenjie, Wu, Zhi, Wurm, Michael, Wurtz, Jacques, Wysotzki, Christian, Xi, Yufei, Xia, Dongmei, Xie, Yuguang, Xie, Zhangquan, Xing, Zhizhong, Xu, Benda, Xu, Donglian, Xu, Fanrong, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Xiongbo, Yan, Yupeng, Yang, Anbo, Yang, Changgen, Yang, Huan, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yao, Haifeng, Yasin, Zafar, Ye, Jiaxuan, Ye, Mei, Yegin, Ugur, Yermia, Frédéric, Yi, Peihuai, Yin, Xiangwei, You, Zhengyun, Yu, Boxiang, Yu, Chiye, Yu, Chunxu, Yu, Hongzhao, Yu, Miao, Yu, Xianghui, Yu, Zeyuan, Yuan, Chengzhuo, Yuan, Ying, Yuan, Zhenxiong, Yuan, Ziyi, Yue, Baobiao, Zafar, Noman, Zambanini, Andre, Zeng, Pan, Zeng, Shan, Zeng, Tingxuan, Zeng, Yuda, Zhan, Liang, Zhang, Feiyang, Zhang, Guoqing, Zhang, Haiqiong, Zhang, Honghao, Zhang, Jiawen, Zhang, Jie, Zhang, Jingbo, Zhang, Peng, Zhang, Qingmin, Zhang, Shiqi, Zhang, Tao, Zhang, Xiaomei, Zhang, Xuantong, Zhang, Yan, Zhang, Yinhong, Zhang, Yiyu, Zhang, Yongpeng, Zhang, Yuanyuan, Zhang, Yumei, Zhang, Zhenyu, Zhang, Zhijian, Zhao, Fengyi, Zhao, Jie, Zhao, Rong, Zhao, Shujun, Zhao, Tianchi, Zheng, Dongqin, Zheng, Hua, Zheng, Minshan, Zheng, Yangheng, Zhong, Weirong, Zhou, Jing, Zhou, Li, Zhou, Nan, Zhou, Shun, Zhou, Xiang, Zhu, Jiang, Zhu, Kejun, Zhuang, Honglin, Zong, Liang, and Zou, Jiaheng

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). A ton-level liquid scintillator detector will be placed at about 30 m from a core of the Taishan Nuclear Power Plant. The reactor antineutrino spectrum will be measured with sub-percent energy resolution, to provide a reference spectrum for future reactor neutrino experiments, and to provide a benchmark measurement to test nuclear databases. A spherical acrylic vessel containing 2.8 ton gadolinium-doped liquid scintillator will be viewed by 10 m^2 Silicon Photomultipliers (SiPMs) of >50% photon detection efficiency with almost full coverage. The photoelectron yield is about 4500 per MeV, an order higher than any existing large-scale liquid scintillator detectors. The detector operates at -50 degree C to lower the dark noise of SiPMs to an acceptable level. The detector will measure about 2000 reactor antineutrinos per day, and is designed to be well shielded from cosmogenic backgrounds and ambient radioactivities to have about 10% background-to-signal ratio. The experiment is expected to start operation in 2022., Comment: 134 pages, 114 figures

Published
2020

177. Efficient Bayesian inversion for shape reconstruction of lithography masks

Author

Farchmin, Nando, Hammerschmidt, Martin, Schneider, Philipp-Immanuel, Wurm, Matthias, Bodermann, Bernd, Bär, Markus, and Heidenreich, Sebastian

Subjects
Physics - Data Analysis, Statistics and Probability, Physics - Accelerator Physics
Abstract

Background: Scatterometry is a fast, indirect and non-destructive optical method for quality control in the production of lithography masks. To solve the inverse problem in compliance with the upcoming need for improved accuracy, a computationally expensive forward model has to be defined which maps geometry parameters to diffracted light intensities. Aim: To quantify the uncertainties in the reconstruction of the geometry parameters, a fast to evaluate surrogate for the forward model has to be introduced. Approach: We use a non-intrusive polynomial chaos based approximation of the forward model which increases speed and thus enables the exploration of the posterior through direct Bayesian inference. Additionally, this surrogate allows for a global sensitivity analysis at no additional computational overhead. Results: This approach yields information about the complete distribution of the geometry parameters of a silicon line grating, which in return allows to quantify the reconstruction uncertainties in the form of means, variances and higher order moments of the parameters. Conclusion: The use of a polynomial chaos surrogate allows to quantify both parameter influences and reconstruction uncertainties. This approach is easy to use since no adaptation of the expensive forward model is required., Comment: arXiv admin note: substantial text overlap with arXiv:1910.14435

Published
2020
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178. Differential Cross Sections for Neutron-Proton Scattering in the Region of the $d^*(2380)$ Dibaryon Resonance

Author

Adlarson, P., Augustyniak, W., Bardan, W., Bashkanov, M., Bergmann, F. S., Berłowski, M., Bhatt, H., Büscher, M., Calén, H., Ciepał, I., Clement, H., Coderre, D., Czerwiński, E., Demmich, K., Doroshkevich, E., Engels, R., Erven, A., Erven, W., Eyrich, W., Fedorets, P., Föhl, K., Fransson, K., Goldenbaum, F., Goslawski, P., Goswami, A., Grigoryev, K., Gullström, C. --O., Hauenstein, F., Heijkenskjöld, L., Hejny, V., Hodana, M., Höistad, B., Hüsken, N., Jany, A., Jany, B. R., Johansson, T., Kamys, B., Kemmerling, G., Khan, F. A., Khoukaz, A., Kirillov, D. A., Kistryn, S., Kleines, H., Kłos, B., Krapp, M., Krzemień, W., Kulessa, P., Kupść, A., Lalwani, K., Lersch, D., Lorentz, B., Magiera, A., Maier, R., Marciniewski, P., Mariański, B., Mikirtychiants, M., Morsch, H. -P., Moskal, P., Ohm, H., Ozerianska, I., del Rio, E. Perez, Piskunov, N. M., Podkopał, P., Prasuhn, D., Pricking, A., Pysz, K., Pyszniak, A., Redmer, C. F., Ritman, J., Roy, A., Rudy, Z., Sawant, S., Schadmand, S., Sefzick, T., Serdyuk, V., Siudak, R., Skorodko, T., Skurzok, M., Smyrski, J., Sopov, V., Stassen, R., Stepaniak, J., Stephan, E., Sterzenbach, G., Stockhorst, H., Ströher, H., Szczurek, A., Täschner, A., Trzciński, A., Varma, R., Wolke, M., Wrońska, A., Wüstner, P., Wurm, P., Yamamoto, A., Yurev, L., Zabierowski, J., Zink, A., Złomańczuk, J., {Ż}uprański, P., {Ż}urek, M., Workman, R. L., Briscoe, W. J., Strakovsky, I. I., and Švarc, A.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

Differential cross sections have been extracted from exclusive and kinematically complete high-statistics measurements of quasifree polarized $\vec{n}p$ scattering performed in the energy region of the $d^*(2380)$ dibaryon resonance covering the the range of beam energies $T_n$ = 0.98 - 1.29 GeV ($\sqrt s$ = 2.32 - 2.44 GeV). The experiment was carried out with the WASA-at-COSY setup having a polarized deuteron beam impinged on the hydrogen pellet target and utilizing the quasifree process $dp \to np + p_{spectator}$. That way the $np$ differential cross section $\sigma(\Theta)$ was measured over a large angular range. The obtained angular distributions complement the corresponding analyzing power $A_y(\Theta)$ measurements published previously. A SAID partial-wave analysis incorporating the new data strengthens the finding of a resonance pole in the coupled $^3D_3 - ^3G_3$ waves.

Published
2020
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179. Planetesimals in Rarefied Gas: Wind Erosion in Slip Flow

Author

Demirci, Tunahan, Schneider, Niclas, Steinpilz, Tobias, Bogdan, Tabea, Teiser, Jens, and Wurm, Gerhard

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A planetesimal moves through the gas of its protoplanetary disc where it experiences a head wind. Though the ambient pressure is low, this wind can erode and ultimately destroy the planetesimal if the flow is strong enough. For the first time, we observe wind erosion in ground based and microgravity experiments at pressures relevant in protoplanetary discs, i.e. down to $10^{-1}\, \rm mbar$. We find that the required shear stress for erosion depends on the Knudsen number related to the grains at the surface. The critical shear stress to initiate erosion increases as particles become comparable to or larger than the mean free path of the gas molecules. This makes pebble pile planetesimals more stable at lower pressure. However, it does not save them as the experiments also show that the critical shear stress to initiate erosion is very low for sub-millimetre sized grains.

Published
2020
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180. A class of three-dimensional gyroviscous magnetohydrodynamic models

Author

Lingam, Manasvi, Morrison, Philip J., and Wurm, Alexander

Subjects
Physics - Plasma Physics, Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

A Hamiltonian and action principle formalism for deriving three-dimensional gyroviscous magnetohydrodynamic models is presented. The uniqueness of the approach in constructing the gyroviscous tensor from first principles and its ability to explain the origin of the gyromap and the gyroviscous terms are highlighted. The procedure allows for the specification of free functions, which can be used to generate a wide range of gyroviscous models. Through the process of reduction, the noncanonical Hamiltonian bracket is obtained and briefly analysed., Comment: Published in J. Plasma Phys.; 26 pages, 0 figures, 0 tables

Published
2020
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181. SND@LHC

Author

SHiP Collaboration, Ahdida, C., Akmete, A., Albanese, R., Alexandrov, A., Andreini, M., Anokhina, A., Aoki, S., Arduini, G., Atkin, E., Azorskiy, N., Back, J. J., Bagulya, A., Santos, F. Baaltasar Dos, Baranov, A., Bardou, F., Barker, G. J., Battistin, M., Bauche, J., Bay, A., Bayliss, V., Bencivenni, G., Berdnikov, A. Y., Berdnikov, Y. A., Bertani, M., Bestmann, P., Betancourt, C., Bezshyiko, I., Bezshyyko, O., Bick, D., Bieschke, S., Blanco, A., Boehm, J., Bogomilov, M., Boiarska, I., Bondarenko, K., Bonivento, W. M., Borburgh, J., Boyarsky, A., Brenner, R., Breton, D., Buonocore, L. R., Büscher, V., Buonaura, A., Buontempo, S., Cadeddu, S., Calcaterra, A., Calviani, M., Campanelli, M., Canale, V., Casolino, M., Cerutti, F., Charitonidis, N., Chau, P., Chauveau, J., Chepurnov, A., Chernyavskiy, M., Choi, K. -Y., Chumakov, A., Ciambrone, P., Cicero, V., Congedo, L., Cornelis, K., Cristinziani, M., Crupano, A., Dallavalle, G. M., Datwyler, A., D'Ambrosio, N., D'Appollonio, G., de Asmundis, R., D'Archiac, P. T. De Bryas Dexmiers, Saraiva, J. De Carvalho, De Lellis, G., de Magistris, M., De Roeck, A., De Serio, M., De Simone, D., Dedenko, L., Dergachev, P., Di Crescenzo, A., Di Giulio, L., Di Marco, N., Dib, C., Dijkstra, H., Dmitrenko, V., Dmitrievskiy, S., Dougherty, L. A., Dolmatov, A., Domenici, D., Donskov, S., Drohan, V., Dubreuil, A., Durhan, O., Ehlert, M., Elikkaya, E., Enik, T., Etenko, A., Fabbri, F., Fedin, O., Fedotovs, F., Felici, G., Ferrillo, M., Ferro-Luzzi, M., Filippov, K., Fini, R. A., Fonte, P., Franco, C., Fraser, M., Fresa, R., Froeschl, R., Fukuda, T., Galati, G., Gall, J., Gatignon, L., Gavrilov, G., Gentile, V., Goddard, B., Golinka-Bezshyyko, L., Golovatiuk, A., Golubkov, D., Golutvin, A., Gorbounov, P., Gorbunov, D., Gorbunov, S., Gorkavenko, V., Gorshenkov, M., Grachev, V., Grandchamp, A. L., Graverini, E., Grenard, J. -L., Grenier, D., Grichine, V., Gruzinskii, N., Guler, A. M., Guz, Yu., Haefeli, G. J., Hagner, C., Hakobyan, H., Harris, I. W., van Herwijnen, E., Hessler, C., Hollnagel, A., Hosseini, B., Hushchyn, M., Iaselli, G., Iengo, P., Iuliano, A., Jacobsson, R., Joković, D., Jonker, M., Kadenko, I., Kain, V., Kaiser, B., Kamiscioglu, C., Karpenkov, D., Kershaw, K., Khabibullin, M., Khalikov, E., Khaustov, G., Khoriauli, G., Khotyantsev, A., Kim, Y. G., Kim, V., Kitagawa, N., Ko, J. -W., Kodama, K., Kolesnikov, A., Kolev, D. I., Kolosov, V., Komatsu, M., Kono, A., Konovalova, N., Kormannshaus, S., Korol, I., Korol'ko, I., Korzenev, A., Kostyukhin, V., Platia, E. Koukovini, Kovalenko, S., Krasilnikova, I., Kudenko, Y., Kurbatov, E., Kurbatov, P., Kurochka, V., Kuznetsova, E., Lacker, H. M., Lamont, M., Lanfranchi, G., Lantwin, O., Lauria, A., Lee, K. S., Lee, K. Y., Lévy, J. -M., Loschiavo, V. P., Lopes, L., Sola, E. Lopez, Lyubovitskij, V., Maalmi, J., Magnan, A., Maleev, V., Malinin, A., Manabe, Y., Managadze, A. K., Manfredi, M., Marsh, S., Marshall, A. M., Mefodev, A., Mermod, P., Miano, A., Mikado, S., Mikhaylov, Yu., Milstead, D. A., Mineev, O., Montanari, A., Montesi, M. C., Morishima, K., Movchan, S., Muttoni, Y., Naganawa, N., Nasybulin, S., Ninin, P., Nishio, A., Novikov, A., Obinyakov, B., Ogawa, S., Okateva, N., Opitz, B., Osborne, J., Ovchynnikov, M., Owtscharenko, N., Owen, P. H., Pacholek, P., Paoloni, A., Park, B. D., Passeggio, G., Pastore, A., Patel, M., Pereyma, D., Perillo-Marcone, A., Petkov, G. L., Petridis, K., Petrov, A., Podgrudkov, D., Poliakov, V., Polukhina, N., Prieto, J. Prieto, Prokudin, M., Prota, A., Quercia, A., Rademakers, A., Rakai, A., Ratnikov, F., Rawlings, T., Redi, F., Ricciardi, S., Rinaldesi, M., Rodin, Volodymyr, Rodin, Viktor, Robbe, P., Cavalcante, A. B. Rodrigues, Roganova, T., Rokujo, H., Rosa, G., Rovelli, T., Ruchayskiy, O., Ruf, T., Gilarte, M. Sabate, Samoylenko, V., Samsonov, V., Galan, F. Sanchez, Diaz, P. Santos, Ull, A. Sanz, Saputi, A., Savchenko, E. S., Schliwinski, J. S., Schmidt-Parzefall, W., Schneider, O., Sekhniaidze, G., Serra, N., Sgobba, S., Shadura, O., Shakin, A., Shaposhnikov, M., Shatalov, P., Shchedrina, T., Shchutska, L., Shevchenko, V., Shibuya, H., Shihora, L., Shirobokov, S., Shustov, A., Silverstein, S. B., Simone, S., Simoniello, R., Skorokhvatov, M., Smirnov, S., Sohn, J. Y., Sokolenko, A., Solodko, E., Starkov, N., Stoel, L., Stramaglia, M. E., Strekalina, D., Sukhonos, D., Suzuki, Y., Takahashi, S., Tastet, J. L., Teterin, P., Naing, S. Than, Timiryasov, I., Tioukov, V., Tommasini, D., Torii, M., Tosi, N., Tramontano, F., Treille, D., Tsenov, R., Ulin, S., Ursov, E., Ustyuzhanin, A., Uteshev, Z., Vankova-Kirilova, G., Vannucci, F., Vendeuvre, C., Venturi, V., Vilchinski, S., Vincke, Heinz, Vincke, Helmut, Visone, C., Vlasik, K., Volkov, A., Voronkov, R., van Waasen, S., Wanke, R., Wertelaers, P., Williams, O., Woo, J. -K., Wurm, M., Xella, S., Yilmaz, D., Yilmazer, A. U., Yoon, C. S., Zaytsev, Yu., and Zimmerman, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We propose to build and operate a detector that, for the first time, will measure the process $pp\to\nu X$ at the LHC and search for feebly interacting particles (FIPs) in an unexplored domain. The TI18 tunnel has been identified as a suitable site to perform these measurements due to very low machine-induced background. The detector will be off-axis with respect to the ATLAS interaction point (IP1) and, given the pseudo-rapidity range accessible, the corresponding neutrinos will mostly come from charm decays: the proposed experiment will thus make the first test of the heavy flavour production in a pseudo-rapidity range that is not accessible by the current LHC detectors. In order to efficiently reconstruct neutrino interactions and identify their flavour, the detector will combine in the target region nuclear emulsion technology with scintillating fibre tracking layers and it will adopt a muon identification system based on scintillating bars that will also play the role of a hadronic calorimeter. The time of flight measurement will be achieved thanks to a dedicated timing detector. The detector will be a small-scale prototype of the scattering and neutrino detector (SND) of the SHiP experiment: the operation of this detector will provide an important test of the neutrino reconstruction in a high occupancy environment., Comment: Letter of Intent

Published
2020

182. Table-Top Scene Analysis Using Knowledge-Supervised MCMC

Author

Liu, Ziyuan, Chen, Dong, Wurm, Kai M., and von Wichert, Georg

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Robotics
Abstract

In this paper, we propose a probabilistic method to generate abstract scene graphs for table-top scenes from 6D object pose estimates. We explicitly make use of task-specfic context knowledge by encoding this knowledge as descriptive rules in Markov logic networks. Our approach to generate scene graphs is probabilistic: Uncertainty in the object poses is addressed by a probabilistic sensor model that is embedded in a data driven MCMC process. We apply Markov logic inference to reason about hidden objects and to detect false estimates of object poses. The effectiveness of our approach is demonstrated and evaluated in real world experiments.

Published
2020

183. Lifting Grains by the Transient Low Pressure in a Martian Dust Devil

Author

Bila, Tetyana, Wurm, Gerhard, Onyeagusi, Florence Chioma, and Teiser, Jens

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Lifting dust and sand into the thin Martian atmosphere is a challenging problem. Atmospheric pressure excursions within dust devils have been proposed to support lifting. We verify this idea in laboratory experiments. Pressure differences up to a few Pa are applied along particle layers of 50 to 400 $\rm \mu m$. As samples we used glass beads of $\sim$50 $\rm \mu m$ diameter and irregular basalt grains of $\sim$20 $\rm \mu m$ in size. The total ambient pressure of air was set to 600 Pa. Particles are ejected at pressure differences as low as 2.0 $\rm \pm$ 0.8 Pa. In the case of glass beads, the ejected grains returning to the particle bed can trigger new particle ejections as they reduce cohesion and release the tension from other grains. Therefore, few impacting grains might be sufficient to sustain dust lifting in a dust devil at even lower pressure differences. Particle lift requires a very thin, $\sim$100 $\rm \mu m$, low permeability particle layer on top of supporting ground with larger pore space. Assuming this, our experiments support the idea that pressure excursions in Martian dust devils release grains from the ground.

Published
2020
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184. Early kinetics of C reactive protein for cancer-agnostic prediction of therapy response and mortality in patients treated with immune checkpoint inhibitors: a multicenter cohort study

Author

Matthias Preusser, Erika Richtig, Florian Moik, Cihan Ay, Martin Pichler, Florian Posch, Armin Gerger, Lukas Koch, Thomas Bauernhofer, Thomas Winder, Dominik A Barth, Sarah Steinlechner, Marie-Christina Mayer, Amelie M Sandner, Franziska Berton, Verena Schlintl, Nikolaus John, Robert Wurm, Patrick Reimann, Christoph Wohlkönig, Philipp J Jost, Angelika Terbuch, and Jakob Michael Riedl

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background C reactive protein (CRP) kinetics have recently been suggested as predictive biomarkers for the efficacy of immune checkpoint inhibitor (ICI) therapy in selected cancer types. The aim of this study was to characterize early CRP kinetics as a tumor-agnostic biomarker for ICI treatment outcomes.Methods In this multicenter retrospective cohort study, two independent cohorts of patients with various cancer types undergoing palliative ICI treatment at Austrian academic centers served as the discovery (n=562) and validation cohort (n=474). Four different patterns of CRP kinetics in the first 3 months of ICI therapy were defined (CRP-flare responders, CRP-responders, CRP non-responders, patients with all-normal CRP). Objective response rate (ORR), progression-free survival (PFS) and overall survival (OS) were defined as coprimary endpoints. Univariable and multivariable logistic regression, landmark analysis and Cox regression including CRP kinetics as time-dependent variable were performed.Results The ORR in patients with all-normal CRP, CRP responders, CRP flare-responders and CRP non-responders was 41%, 38%, 31% and 12%, respectively. The median OS and PFS estimates were 24.5 months (95% CI 18.5 to not reached) and 8.2 months (95% CI 5.9 to 12.0) in patients with all-normal CRP, 16.1 months (95% CI 12.6 to 19-8) and 6.1 months (95% CI 4.9 to 7.2) in CRP-responders, 14.0 months (95% CI 8.5 to 19.4) and 5.7 months (95% CI 4.1 to 8.5) in CRP flare-responders and 8.1 months (95% CI 5.8 to 9.9) and 2.3 months (95% CI 2.2 to 2.8) in CRP non-responders (log-rank p for PFS and OS

Published
2023
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185. Are public green spaces distributed fairly? A nationwide analysis based on remote sensing, OpenStreetMap and census data

Author

Matthias Weigand, Michael Wurm, Ariane Droin, Thomas Stark, Jeroen Staab, Jürgen Rauh, and Hannes Taubenböck

Subjects
Public green space, green land cover, environmental justice, remote sensing, OpenStreetMap, Physical geography, GB3-5030
Abstract

AbstractGreen space (GS) is a crucial resource in urban areas, but not spatially uniformly distributed. We compare the availability of GS on a national scale using green land cover (GLC) and public green space (PGS). Using spatial census data we analyse GS availability and accessibility for the German population. The average GS availability differs by a factor of three between GLC and PGS. 19.2 % of Germans find less than the WHO defined target for PGS in their neighbourhood. PGS is less equally distributed among the population than GLC, and green space equity varies significantly between rural and urban areas. In areas with multi-family homes, a higher share of the population has access to sufficient PGS than in areas with predominantly single-family homes. We find a negative relation between GLC availability and share of immigrant population, which does not extend to PGS.

Published
2023
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186. Single fibre coating of cellulose acetate fibres for hydrophilic modification using carboxymethylated starch

Author

Florian Wurm, Karl-Jürgen Mann, Bernhard Seidl, Martin Kozich, Tung Pham, and Thomas Bechtold

Subjects
Bio-based, Hydrophilic modification, Composite, Single fibre, Carboxymethylated starch, Cellulose acetate, Biochemistry, QD415-436
Abstract

Hydrophilic bio-based and biodegradable fabrics and fibres can be an alternative to petroleum-based fabrics and fibres. Hydrophilic modifications of conventional textile structures by compositing can be introduced on a fabric as well as on a fibre level. Here, the coating of hydrophobic cellulose acetate multifilaments with carboxymethylated starch (CMS) pastes is reported. The CA fibres were drawn through starch preparations with varying degrees of substitution for coating. To ensure CMS anchorage, citric acid was added to cross-link the hydrophilic starch preparation itself and to the substrate. Cross-linking and CMS gel viscoelasticity were determined using a heated FT-IR stage and a rheometer respectively. The composites were also characterised for citric acid elution, as their degree of swelling in water vapour. As the amount of crosslinker increased, the gel viscoelasticity increased, but so did the citric acid elution in swelling media. Through several drying and swelling steps, the hydrophilic CMS structures lose their swelling ability. Coated fibres were also tested in a fine wash. The hydrophilic coating is depleted.An estimate of the chemical consumption for the production of such composites is given and compared with related approaches. As the chemical modification only affects the sheath, the chemical consumption can be reduced.

Published
2023
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187. Towards more homogeneous character in 3D printed photopolymers by the addition of nanofillers

Author

Mariola Robakowska, Ian Gibson, Remko Akkerman, Frederik R. Wurm, and Hubert Gojzewski

Subjects
3D printing, Photopolymer nanocomposite, Layer interface, AFM stiffness, Polymers and polymer manufacture, TP1080-1185
Abstract

The performance of 3D printed materials differs from that of fully cured polymer materials because of the presence of interfacial areas between consecutively joined layers. These interfaces result in an inhomogeneous character of the printed objects and is frequently reported as their main cause of failures. We noted that the presence of nanosilica particles strengthens the 3D printed layers of the polymer matrix by inducing its additional crosslinking. A model resin composed of poly (ethylene glycol) diacrylate (PEGDA) and nanosilica (Aerosil R972) is used for vat photopolymer 3D printing. Evolution of the interface properties at different nanosilica loadings is tracked by mapping its surface stiffness (Young's modulus mapping) using quantitative Atomic Force Microscopy (AFM). Our research demonstrates that incorporating 6% w/v nanosilica in the polyPEGDA matrix unifies its mechanical properties within the layer, leading to a substantial reduction of microscopic inhomogeneity in the final 3D printed materials.

Published
2023
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188. Litter on the streets - solid waste detection using VHR images

Author

Yrneh Zarit Ulloa-Torrealba, Andreas Schmitt, Michael Wurm, and Hannes Taubenböck

Subjects
Solid waste, sanitation, deprivation, remote sensing, machine learning, superpixels, Oceanography, GC1-1581, Geology, QE1-996.5
Abstract

ABSTRACTFailures in urban areas’ solid waste management lead to clandestine garbage dumping and pollution. This affects sanitation and public human hygiene, deteriorates quality of life, and contributes to deprivation. This study aimed to test a combination of machine learning, high-resolution earth observation and GIS data to detect diverse categories of residual waste on the streets, such as sacks and construction debris. We conceptualised five different classes of solid waste from image interpretation: “Sure”, “Half-sure”, “Not-sure”, “Dispersed”, and “Non-garbage”. We tested a combination of k-means-based segmentation and supervised random forest to investigate the capabilities of automatic classification of these waste classes. The model can detect the presence of solid waste on the streets and achieved an accuracy of up from 73.95%–95.76% for the class “Sure”. Moreover, a building extraction using an EfficientNet deep-learning-based semantic segmentation allowed masking the rooftops. This improved the accuracy of the classes “Sure” and “Non-garbage”. The systematic evaluation of all parameters considered in this model provides a robust and reliable method of solid waste detection for decision-makers. These results highlight areas where insufficient waste management affects the citizens of a given city.

Published
2023
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189. Two-Dimensional Post-Traumatic Measurements of Orbital Floor Blowout Fractures Underestimate Defect Sizes Compared to Three-Dimensional Approaches

Author

Juergen Taxis, Lena Ungerboeck, Mika R. Gehrking, Constantin Motel, Matthias Wurm, Alexander W. Eckert, Gerrit Spanier, Felix Nieberle, Natascha Platz Batista da Silva, Nils Ludwig, Johannes K. Meier, Tobias Ettl, Torsten E. Reichert, and Steffen Spoerl

Subjects
orbital floor fracture, blowout fracture, 2D fracture measurement, 3D fracture measurement, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Orbital floor fractures represent a common fracture type of the midface and are standardly diagnosed clinically as well as radiologically using linear measurement methods. The aim of this study was to evaluate the accuracy of diagnostic measurements of isolated orbital floor fractures based on two-dimensional (2D) and three-dimensional (3D) measurement techniques. A cohort of 177 patients was retrospectively and multi-centrically evaluated after surgical treatment of an orbital floor fracture between 2010 and 2020. In addition to 2D and 3D measurements of the fracture area, further fracture-related parameters were investigated. Calculated fracture areas using the 2D measurement technique revealed an average area of 287.59 mm2, whereas the 3D measurement showed fracture areas with a significantly larger average value of 374.16 mm2 (p < 0.001). On average, the 3D measurements were 1.53-fold larger compared to the 2D measurements. This was observed in 145 patients, whereas only 32 patients showed smaller values in the 3D-based approach. However, the process duration of the 3D measurement took approximately twice as long as the 2D-based procedure. Nonetheless, 3D-based measurement of orbital floor defects provides a more accurate estimation of the fracture area than the 2D-based procedure and can be helpful in determining the indication and planning the surgical procedure.

Published
2023
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190. The relationship between pre-surgery self-rated health and changes in functional and mental health in older adults: insights from a prospective observational study

Author

Eva F. Mennig, Sarah K. Schäfer, Gerhard W. Eschweiler, Michael A. Rapp, Christine Thomas, and Susanne Wurm

Subjects
Self-rated health, Functional health, Mental health problems, Older adults, Elective surgery, Longitudinal, Geriatrics, RC952-954.6
Abstract

Abstract Background Elective surgeries are among the most common health stressors in later life and put a significant risk at functional and mental health, making them an important target of research into healthy aging and physical resilience. Large-scale longitudinal research mostly conducted in non-clinical samples provided support of the predictive value of self-rated health (SRH) for both functional and mental health. Thus, SRH may have the potential to predict favorable adaptation processes after significant health stressors, that is, physical resilience. So far, a study examining the interplay between SRH, functional and mental health and their relative importance for health changes in the context of health stressors was missing. The present study aimed at addressing this gap. Methods We used prospective data of 1,580 inpatients (794 complete cases) aged 70 years or older of the PAWEL study, collected between October 2017 and May 2019 in Germany. Our analyses were based on SRH, functional health (Barthel Index) and self-reported mental health problems (PHQ-4) before and 12 months after major elective surgery. To examine changes and interrelationships in these health indicators, bivariate latent change score (BLCS) models were applied. Results Our analyses provided evidence for improvements of SRH, functional and mental health from pre-to-post surgery. BLCS models based on complete cases and the total sample pointed to a complex interplay of SRH, functional health and mental health with bidirectional coupling effects. Better pre-surgery SRH was associated with improvements in functional and mental health, and better pre-surgery functional health and mental health were associated with improvements in SRH from pre-to-post surgery. Effects of pre-surgery SRH on changes in functional health were smaller than those of functional health on changes in SRH. Conclusions Meaningful changes of SRH, functional and mental health and their interplay could be depicted for the first time in a clinical setting. Our findings provide preliminary support for SRH as a physical resilience factor being associated with improvements in other health indicators after health stressors. Longitudinal studies with more timepoints are needed to fully understand the predictive value of SRH for multidimensional health. Trial registration PAWEL study, German Clinical Trials Register, number DRKS00013311. Registered 10 November 2017 – Retrospectively registered, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00013311 .

Published
2023
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191. A model of timing in simple anticipatory decisions

Author

Wurm, Alexander, Sokratous, Konstantina, Hawkins, Guy, and Kvam, Peter

Subjects
cognitive science
Abstract

While most models of response times have focused on reactive response times, many of the decisions we make involve planning ahead and making anticipatory responses. We present an accumulator model of these anticipatory timing choices, where a decision maker must make a response at a specific time depending on when they expect an event to occur. This model is applied to simple perceptual decisions where participants must determine the trajectory of a stimulus and anticipate its future location. We manipulate the stimulus speed, its travel distance, and the length of time it is occluded, requiring the decision maker to mentally represent its position and motion. Generally, we find that participants anticipatory tend to be much more likely to respond too late than too early. This pattern of results can be accounted for by a Wald accumulator model where the drift, threshold, and non-decision time change with the stimulus manipulations.

Published
2021

193. Diagnostic value of water-fat-separated images and CT-like susceptibility-weighted images extracted from a single ultrashort echo time sequence for the evaluation of vertebral fractures and degenerative changes of the spine

Author

Feuerriegel, Georg C., Kronthaler, Sophia, Boehm, Christof, Renz, Martin, Leonhardt, Yannik, Gassert, Florian, Foreman, Sarah C., Weiss, Kilian, Wurm, Markus, Liebig, Thomas, Makowski, Marcus R., Schwaiger, Benedikt J., Karampinos, Dimitrios C., and Gersing, Alexandra S.

Published
2023
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196. Click Chemistry with Cell-Permeable Fluorophores Expands the Choice of Bioorthogonal Markers for Two-Color Live-Cell STED Nanoscopy

Author

Carola Gregor, Florian Grimm, Jasmin Rehman, Christian A. Wurm, and Alexander Egner

Subjects
super-resolution microscopy, two-color STED, live-cell imaging, click labeling, Cytology, QH573-671
Abstract

STED nanoscopy allows for the direct observation of dynamic processes in living cells and tissues with diffraction-unlimited resolution. Although fluorescent proteins can be used for STED imaging, these labels are often outperformed in photostability by organic fluorescent dyes. This feature is especially crucial for time-lapse imaging. Unlike fluorescent proteins, organic fluorophores cannot be genetically fused to a target protein but require different labeling strategies. To achieve simultaneous imaging of more than one protein in the interior of the cell with organic fluorophores, bioorthogonal labeling techniques and cell-permeable dyes are needed. In addition, the fluorophores should preferentially emit in the red spectral range to reduce the potential phototoxic effects that can be induced by the STED light, which further restricts the choice of suitable markers. In this work, we selected five different cell-permeable organic dyes that fulfill all of the above requirements and applied them for SPIEDAC click labeling inside living cells. By combining click-chemistry-based protein labeling with other orthogonal and highly specific labeling methods, we demonstrate two-color STED imaging of different target structures in living specimens using different dye pairs. The excellent photostability of the dyes enables STED imaging for up to 60 frames, allowing the observation of dynamic processes in living cells over extended time periods at super-resolution.

Published
2024
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197. Mobocertinib in Patients with EGFR Exon 20 Insertion-Positive Non-Small Cell Lung Cancer (MOON): An International Real-World Safety and Efficacy Analysis

Author

Oliver Illini, Felix Carl Saalfeld, Petros Christopoulos, Michaël Duruisseaux, Anders Vikström, Nir Peled, Ingel Demedts, Elizabeth Dudnik, Anna Eisert, Sayed M. S. Hashemi, Urska Janzic, Waleed Kian, Katja Mohorcic, Saara Mohammed, Maria Silvoniemi, Sacha I. Rothschild, Christian Schulz, Claas Wesseler, Alfredo Addeo, Karin Armster, Malinda Itchins, Marija Ivanović, Diego Kauffmann-Guerrero, Jussi Koivunen, Jonas Kuon, Nick Pavlakis, Berber Piet, Martin Sebastian, Janna-Lisa Velthaus-Rusik, Luciano Wannesson, Marcel Wiesweg, Robert Wurm, Corinna Albers-Leischner, Daniela E. Aust, Melanie Janning, Hannah Fabikan, Sylvia Herold, Anna Klimova, Sonja Loges, Yana Sharapova, Maret Schütz, Christoph Weinlinger, Arschang Valipour, Tobias Raphael Overbeck, Frank Griesinger, Marko Jakopovic, Maximilian J. Hochmair, and Martin Wermke

Subjects
non-small cell lung cancer, EGFR exon 20 inhibitors, mobocertinib, real-world data, exon 20 insertion, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed to target EGFR Ex20. We performed an international, real-world safety and efficacy analysis on patients with EGFR Ex20-positive NSCLC enrolled in a mobocertinib early access program. We explored the mechanisms of resistance by analyzing postprogression biopsies, as well as cross-resistance to amivantamab. Data from 86 patients with a median age of 67 years and a median of two prior lines of treatment were analyzed. Treatment-related adverse events (TRAEs) occurred in 95% of patients. Grade ≥3 TRAEs were reported in 38% of patients and included diarrhea (22%) and rash (8%). In 17% of patients, therapy was permanently discontinued, and two patients died due to TRAEs. Women were seven times more likely to discontinue treatment than men. In the overall cohort, the objective response rate to mobocertinib was 34% (95% CI, 24–45). The response rate in treatment-naïve patients was 27% (95% CI, 8–58). The median progression-free and overall survival was 5 months (95% CI, 3.5–6.5) and 12 months (95% CI, 6.8–17.2), respectively. The intracranial response rate was limited (13%), and one-third of disease progression cases involved the brain. Mobocertinib also showed antitumor activity following EGFR Ex20-specific therapy and vice versa. Potential mechanisms of resistance to mobocertinib included amplifications in MET, PIK3CA, and NRAS. Mobocertinib demonstrated meaningful efficacy in a real-world setting but was associated with considerable gastrointestinal and cutaneous toxicity.

Published
2024
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198. Assessing Patient Radiation Exposure in Endoscopic Retrograde Cholangiopancreatography: A Multicenter Retrospective Analysis of Procedural Complexity and Clinical Factors

Author

Touko Kaasalainen, Ekaterina Saukko, Outi Lindström, Marianne Udd, Sara Regnér, Arto Saarela, Ervin Toth, Gabriele Wurm Johansson, Anna-Leena Manninen, Juha Grönroos, and Leena Kylänpää

Subjects
ERCP, fluoroscopy, radiation exposure, procedural complexity, PSC, Medicine (General), R5-920
Abstract

Background and aims: Endoscopic retrograde cholangiopancreatography (ERCP) procedures can result in significant patient radiation exposure. This retrospective multicenter study aimed to assess the influence of procedural complexity and other clinical factors on radiation exposure in ERCP. Methods: Data on kerma-area product (KAP), air-kerma at the reference point (Ka,r), fluoroscopy time, and the number of exposures, and relevant patient, procedure, and operator factors were collected from 2641 ERCP procedures performed at four university hospitals. The influence of procedural complexity, assessed using the American Society for Gastrointestinal Endoscopy (ASGE) and HOUSE complexity grading scales, on radiation exposure quantities was analyzed within each center. The procedures were categorized into two groups based on ERCP indications: primary sclerosing cholangitis (PSC) and other ERCPs. Results: Both the ASGE and HOUSE complexity grading scales had a significant impact on radiation exposure quantities. Remarkably, there was up to a 50-fold difference in dose quantities observed across the participating centers. For non-PSC ERCP procedures, the median KAP ranged from 0.9 to 64.4 Gy·cm2 among the centers. The individual endoscopist also had a substantial influence on radiation dose. Conclusions: Procedural complexity grading in ERCP significantly affects radiation exposure. Higher procedural complexity is typically associated with increased patient radiation dose. The ASGE complexity grading scale demonstrated greater sensitivity to changes in radiation exposure compared to the HOUSE grading scale. Additionally, significant variations in dose indices, fluoroscopy times, and number of exposures were observed across the participating centers.

Published
2024
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200. Recording group and area-specific activity of fattening pigs by using Passive Infrared Detectors on farm

Author

Esther Wurm, Naemi von Jasmund, Inga Tiemann, Kathrin Schulze Rötering, and Wolfgang Büscher

Subjects
animal activity, animal behavior, PID, infrared sensor, welfare, ammonia, Veterinary medicine, SF600-1100
Abstract

Animal activity in pigs can be a direct indicator of animal welfare. Passive infrared detectors (PID) provide one method of measuring animal activity on the pen level as a cost-effective and easy-to-use sensor technique. The study aimed to test PIDs on different commercial farms with fattening pigs. On each farm, a focus pen was selected and group activity, and activity in the feeding and exploration area was measured by using three PIDs. For data evaluation, three continuous 24h time periods were selected for each farm. Additionally, animal behavior was recorded by video cameras for visual scan sampling. To compare the PID outcome with the recorded behaviors, an ethogram was used to categorize active and inactive behaviors. Using scan sampling, the validation of the PID data was based on still frames at 10 min intervals. In addition, barn climate such as temperature, relative humidity, and ammonia concentration were measured. The analysis of seven farms showed a strong correlation between PID data and visual assessment for group activity from 0.67 - 0.91 (p < 0.001; n = 432). For the activity in the feeding area, medium to strong correlations between 0.44 - 0.65 (p < 0.001; n = 327) could be found. The PID data for the exploration area reached correlations with a smaller effect strength. Based on the activity data measured by PIDs, a typical diurnal rhythm for pigs could be found for all farms. Moreover, the PID data indicated different activity patterns depending on, e.g., feeding times and sex group composition. The results demonstrated that PIDs can also be used in different housing conditions for measuring animal activity. In combination with barn climate data, the PIDs can provide useful information for the farmer and also characterize farm-specific management.

Published
2023
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