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151. Human Connectome Project for Disordered Emotional States (HCP-DES)

Author

Tozzi, Leonardo, Chestnut, Megan, Holt-Gosselin, Bailey, Ramirez, Carolina, Gotlib, Ian, Hastie, Trevor, Kerr, Adam, Poldrack, Russell, Wandell, Brian, Wintermark, Max, and Williams, Leanne

Subjects
human connectome project, Mental Disorders, depression, fMRI, Medicine and Health Sciences, RDOC, Psychiatry and Psychology, anxiety, MRI
Abstract

Mental disorders arising from high levels of negative emotion or from the loss of positive emotional experience affect over 400 million people globally. Such states of disordered emotion cut across multiple diagnostic categories of mood and anxiety disorders and are compounded by accompanying disruptions in cognitive function. The Research Domain Criteria (RDoC) initiative spearheaded by the National Institute of Mental Health (NIMH) offers a framework for characterizing the relations between neural circuits and phenotypic profiles of behavior and self-reported symptoms. Our project integrates an RDoC framework with Human Connectome Project (HCP) imaging protocols to characterize disordered emotional states across units of analysis in a sample of 250 individuals suffering from depression and anxiety as well as 50 healthy controls. We focus on the three RDoC constructs most relevant to depression and anxiety: 1) loss and acute threat within the negative valence system domain; 2) reward valuation and responsiveness within the positive valence system domain; and 3) working memory and cognitive control within the cognitive system domain. Upon project completion, all imaging, behavioral and symptom data will be made publicly available through the Coordinating Connectome Facility and the NIMH Data Archive.

Published
2022
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152. Identifying biological clusters of depression and anxiety by means of task fMRI

Author

Tozzi, Leonardo and Williams, Leanne

Abstract

The goal of this project is to test whether brain networks engaged during tasks collected in two large samples at different sites can be used reliably to define clusters of individuals suffering from depression and anxiety. If so, I will then investigate whether cluster assignments are stable in time and relevant for treatment selection.

Published
2022
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153. Investigating the role of individual differences in coping strategies and neural circuit structure in depression and anxiety during the COVID-19 pandemic

Author

Holt-Gosselin, Bailey, Tozzi, Leonardo, Gotlib, Ian, and Williams, Leanne

Subjects
Medical Sciences, Mental and Social Health, FOS: Clinical medicine, Neurosciences, Medicine and Health Sciences, Psychiatry and Psychology, Psychiatric and Mental Health
Abstract

The inability to regulate emotional responses to stressful events has been found to be associated with the development of symptoms of depression and anxiety. Cortical and subcortical brain regions implicated in emotion regulation, and other aspects of self-control, such as the amygdala, dorsal anterior cingulate cortex (dACC), insula, and hippocampus, may be involved in the neural underpinnings of this association. Self-reported coping strategies are one means to assess the attempt to regulate emotion responses and achieve self-control. However, we do not know the extent to which the association between the explicit use of coping strategies and structural variation in these brain regions contributes to experiences of depression and anxiety in response to stressful events. The COVID-19 pandemic is a salient stressful event, worldwide, that is likely to evoke depression and anxiety in many individuals, especially in those who are already experiencing psychiatric illness. In this context, the temporal onset of the pandemic offers a naturalistic design for investigating whether variations in coping strategies and in neural circuit structure that characterize individuals prior to a major stressful event are associated with the severity and/or development of depression and anxiety symptoms as a consequence of that stressful event (i.e., the pandemic). To our knowledge, no study has investigated how coping strategies and neural circuit structure prior to the COVID-19 pandemic relate to the severity of clinical symptoms during the pandemic. In a sample of adult participants with and without clinical symptoms of depression and anxiety prior to the pandemic, we will first assess whether coping strategies (defined as maladaptive or adaptive) are associated with changes in the severity of depression and anxiety symptoms as a function of the COVID-19 pandemic. Second, we will assess whether characteristic variations in the structure of neural circuit regions implicated in self-control and emotion regulation are also associated with changes in depression and anxiety symptoms as a function of the COVID-19 pandemic. Lastly, we will examine whether coping strategies moderate the relationship between neural circuit structure and clinical symptoms during the COVID-19 pandemic.

Published
2022
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161. The TWIN-E project in emotional wellbeing: study protocol and preliminary heritability results across four MRI and DTI measures [Article in special issue: Genetics of brain structure and function. de Zubicaray, Greig; Smit, Dirk; Stein, Jason and van 't Ent (eds)]

Author

Gatt, Justine M., Korgaonkar, Mayuresh S., Schofield, Peter R., Harris, Anthony, Clark, C. Richard, Oakley, Karen L., Ram, Kaushik, Michaelson, Hope, Yap, Sarsha, Stanners, Melinda, Wise, Vikki, and Williams, Leanne M.

Published
2012

162. Intelligence and the Tuning-In of Brain Networks

Author

Stankov, Lazar, Danthiir, Vanessa, and Williams, Leanne M.

Abstract

The phase-synchronization of Gamma-band oscillations has been postulated as a mechanism of "network binding" and implicated in various aspects of perception, memory, and cognition. The current study investigates a possible link between Gamma synchrony and individual differences in intelligence within the theory of fluid and crystallized intelligence, with due reference to Hebbian theory. The hypothesis is that there are significant correlations between cognitive performance and synchronous Gamma activity across diverse brain regions. EEG data were recorded from 35 healthy participants, and the peak magnitude and latency of early and late Gamma Synchrony were extracted using a method for quantifying phase synchronization across multiple sites. Participants also completed 11 diverse cognitive ability tests tapping fluid and crystallized intelligence. Overall, moderate-sized correlations were obtained between accuracy and speed composite scores, derived from the ability tests, and magnitude and latency indices of Gamma synchrony. Phase-synchronous Gamma activity provides a plausible physiological mechanism that might account for individual differences in cognitive abilities.

Published
2006
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167. Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder

Author

Padula, Claudia B., primary, Tenekedjieva, Lea-Tereza, additional, McCalley, Daniel M., additional, Al-Dasouqi, Hanaa, additional, Hanlon, Colleen A., additional, Williams, Leanne M., additional, Kozel, F. Andrew, additional, Knutson, Brian, additional, Durazzo, Timothy C., additional, Yesavage, Jerome A., additional, and Madore, Michelle R., additional

Published
2022
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172. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Author

Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R. I., Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung, Crawford, Steven, Crow, Scott, DiBlasi, Emily, Duriez, Philibert, Fernández-Aranda, Fernando, Fichter, Manfred M., Gallinger, Steven, Glatt, Stephen J., Gorwood, Philip, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine A., Hwu, Hai-Gwo, Jain, Sonia, Jamain, Stéphane, Jiménez-Murcia, Susana, Johnson, Craig, Kaplan, Allan S., Kaye, Walter H., Keel, Pamela K., Kennedy, James L., Klump, Kelly L., Li, Dong, Liao, Shih-Cheng, Lieb, Klaus, Lilenfeld, Lisa, Liu, Chih-Min, Magistretti, Pierre J., Marshall, Christian R., Mitchell, James E., Monson, Eric T., Myers, Richard M., Pinto, Dalila, Powers, Abigail, Ramoz, Nicolas, Roepke, Stefan, Rozanov, Vsevolod, Scherer, Stephen W., Schmahl, Christian, Sokolowski, Marcus, Strober, Michael, Thornton, Laura M., Treasure, Janet, Tsuang, Ming T., Witt, Stephanie H., Woodside, D. Blake, Yilmaz, Zeynep, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Air, Tracy M., Alda, Martin, Alfredsson, Lars, Andreassen, Ole A., Anjorin, Adebayo, Appadurai, Vivek, Soler Artigas, María, Van der Auwera, Sandra, Azevedo, M. Helena, Bass, Nicholas, Bau, Claiton H. D., Baune, Bernhard T., Bellivier, Frank, Berger, Klaus, Biernacka, Joanna M., Bigdeli, Tim B., Binder, Elisabeth B., Boehnke, Michael, Boks, Marco P., Bosch, Rosa, Braff, David L., Bryant, Richard, Budde, Monika, Byrne, Enda M., Cahn, Wiepke, Casas, Miguel, Castelao, Enrique, Cervilla, Jorge A., Chaumette, Boris, Cichon, Sven, Corvin, Aiden, Craddock, Nicholas, Craig, David, Degenhardt, Franziska, Djurovic, Srdjan, Edenberg, Howard J., Fanous, Ayman H., Foo, Jerome C., Forstner, Andreas J., Frye, Mark, Fullerton, Janice M., Gatt, Justine M., Gejman, Pablo V., Giegling, Ina, Grabe, Hans J., Green, Melissa J., Grevet, Eugenio H., Grigoroiu-Serbanescu, Maria, Gutierrez, Blanca, Guzman-Parra, Jose, Hamilton, Steven P., Hamshere, Marian L., Hartmann, Annette, Hauser, Joanna, Heilmann-Heimbach, Stefanie, Hoffmann, Per, Ising, Marcus, Jones, Ian, Jones, Lisa A., Jonsson, Lina, Kahn, René S., Kelsoe, John R., Kendler, Kenneth S., Kloiber, Stefan, Koenen, Karestan C., Kogevinas, Manolis, Konte, Bettina, Krebs, Marie-Odile, Landén, Mikael, Lawrence, Jacob, Leboyer, Marion, Lee, Phil H., Levinson, Douglas F., Liao, Calwing, Lissowska, Jolanta, Lucae, Susanne, Mayoral, Fermin, McElroy, Susan L., McGrath, Patrick, McGuffin, Peter, McQuillin, Andrew, Medland, Sarah E., Mehta, Divya, Melle, Ingrid, Milaneschi, Yuri, Mitchell, Philip B., Molina, Esther, Morken, Gunnar, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nievergelt, Caroline, Nimgaonkar, Vishwajit, Nöthen, Markus M., O'Donovan, Michael C., Ophoff, Roel A., Owen, Michael J., Pato, Carlos, Pato, Michele T., Penninx, Brenda W. J. H., Pimm, Jonathan, Pistis, Giorgio, Potash, James B., Power, Robert A., Preisig, Martin, Quested, Digby, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Ribasés, Marta, Richarte, Vanesa, Rietschel, Marcella, Rivera, Margarita, Roberts, Andrea, Roberts, Gloria, Rouleau, Guy A., Rovaris, Diego L., Rujescu, Dan, Sánchez-Mora, Cristina, Sanders, Alan R., Schofield, Peter R., Schulze, Thomas G., Scott, Laura J., Serretti, Alessandro, Shi, Jianxin, Shyn, Stanley I., Sirignano, Lea, Sklar, Pamela, Smeland, Olav B., Smoller, Jordan W., Sonuga-Barke, Edmund J. S., Spalletta, Gianfranco, Strauss, John S., Świątkowska, Beata, Trzaskowski, Maciej, Turecki, Gustavo, Vilar-Ribó, Laura, Vincent, John B., Völzke, Henry, Walters, James T. R., Shannon Weickert, Cynthia, Weickert, Thomas W., Weissman, Myrna M., Williams, Leanne M., Wray, Naomi R., Zai, Clement C., Ashley-Koch, Allison E., Beckham, Jean C., Hauser, Elizabeth R., Hauser, Michael A., Kimbrel, Nathan A., Lindquist, Jennifer H., McMahon, Benjamin, Oslin, David W., Qin, Xuejun, Agerbo, Esben, Børglum, Anders D., Breen, Gerome, Erlangsen, Annette, Esko, Tõnu, Gelernter, Joel, Hougaard, David M., Kessler, Ronald C., Kranzler, Henry R., Li, Qingqin S., Martin, Nicholas G., McIntosh, Andrew M., Mors, Ole, Nordentoft, Merete, Olsen, Catherine M., Porteous, David, Ursano, Robert J., Wasserman, Danuta, Werge, Thomas, Whiteman, David C., Bulik, Cynthia M., Coon, Hilary, Demontis, Ditte, Docherty, Anna R., Kuo, Po-Hsiu, Lewis, Cathryn M., Mann, J. John, Rentería, Miguel E., Smith, Daniel J., Stahl, Eli A., Stein, Murray B., Streit, Fabian, Willour, Virginia, Ruderfer, Douglas M., Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R. I., Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung, Crawford, Steven, Crow, Scott, DiBlasi, Emily, Duriez, Philibert, Fernández-Aranda, Fernando, Fichter, Manfred M., Gallinger, Steven, Glatt, Stephen J., Gorwood, Philip, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine A., Hwu, Hai-Gwo, Jain, Sonia, Jamain, Stéphane, Jiménez-Murcia, Susana, Johnson, Craig, Kaplan, Allan S., Kaye, Walter H., Keel, Pamela K., Kennedy, James L., Klump, Kelly L., Li, Dong, Liao, Shih-Cheng, Lieb, Klaus, Lilenfeld, Lisa, Liu, Chih-Min, Magistretti, Pierre J., Marshall, Christian R., Mitchell, James E., Monson, Eric T., Myers, Richard M., Pinto, Dalila, Powers, Abigail, Ramoz, Nicolas, Roepke, Stefan, Rozanov, Vsevolod, Scherer, Stephen W., Schmahl, Christian, Sokolowski, Marcus, Strober, Michael, Thornton, Laura M., Treasure, Janet, Tsuang, Ming T., Witt, Stephanie H., Woodside, D. Blake, Yilmaz, Zeynep, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Air, Tracy M., Alda, Martin, Alfredsson, Lars, Andreassen, Ole A., Anjorin, Adebayo, Appadurai, Vivek, Soler Artigas, María, Van der Auwera, Sandra, Azevedo, M. Helena, Bass, Nicholas, Bau, Claiton H. D., Baune, Bernhard T., Bellivier, Frank, Berger, Klaus, Biernacka, Joanna M., Bigdeli, Tim B., Binder, Elisabeth B., Boehnke, Michael, Boks, Marco P., Bosch, Rosa, Braff, David L., Bryant, Richard, Budde, Monika, Byrne, Enda M., Cahn, Wiepke, Casas, Miguel, Castelao, Enrique, Cervilla, Jorge A., Chaumette, Boris, Cichon, Sven, Corvin, Aiden, Craddock, Nicholas, Craig, David, Degenhardt, Franziska, Djurovic, Srdjan, Edenberg, Howard J., Fanous, Ayman H., Foo, Jerome C., Forstner, Andreas J., Frye, Mark, Fullerton, Janice M., Gatt, Justine M., Gejman, Pablo V., Giegling, Ina, Grabe, Hans J., Green, Melissa J., Grevet, Eugenio H., Grigoroiu-Serbanescu, Maria, Gutierrez, Blanca, Guzman-Parra, Jose, Hamilton, Steven P., Hamshere, Marian L., Hartmann, Annette, Hauser, Joanna, Heilmann-Heimbach, Stefanie, Hoffmann, Per, Ising, Marcus, Jones, Ian, Jones, Lisa A., Jonsson, Lina, Kahn, René S., Kelsoe, John R., Kendler, Kenneth S., Kloiber, Stefan, Koenen, Karestan C., Kogevinas, Manolis, Konte, Bettina, Krebs, Marie-Odile, Landén, Mikael, Lawrence, Jacob, Leboyer, Marion, Lee, Phil H., Levinson, Douglas F., Liao, Calwing, Lissowska, Jolanta, Lucae, Susanne, Mayoral, Fermin, McElroy, Susan L., McGrath, Patrick, McGuffin, Peter, McQuillin, Andrew, Medland, Sarah E., Mehta, Divya, Melle, Ingrid, Milaneschi, Yuri, Mitchell, Philip B., Molina, Esther, Morken, Gunnar, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nievergelt, Caroline, Nimgaonkar, Vishwajit, Nöthen, Markus M., O'Donovan, Michael C., Ophoff, Roel A., Owen, Michael J., Pato, Carlos, Pato, Michele T., Penninx, Brenda W. J. H., Pimm, Jonathan, Pistis, Giorgio, Potash, James B., Power, Robert A., Preisig, Martin, Quested, Digby, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Ribasés, Marta, Richarte, Vanesa, Rietschel, Marcella, Rivera, Margarita, Roberts, Andrea, Roberts, Gloria, Rouleau, Guy A., Rovaris, Diego L., Rujescu, Dan, Sánchez-Mora, Cristina, Sanders, Alan R., Schofield, Peter R., Schulze, Thomas G., Scott, Laura J., Serretti, Alessandro, Shi, Jianxin, Shyn, Stanley I., Sirignano, Lea, Sklar, Pamela, Smeland, Olav B., Smoller, Jordan W., Sonuga-Barke, Edmund J. S., Spalletta, Gianfranco, Strauss, John S., Świątkowska, Beata, Trzaskowski, Maciej, Turecki, Gustavo, Vilar-Ribó, Laura, Vincent, John B., Völzke, Henry, Walters, James T. R., Shannon Weickert, Cynthia, Weickert, Thomas W., Weissman, Myrna M., Williams, Leanne M., Wray, Naomi R., Zai, Clement C., Ashley-Koch, Allison E., Beckham, Jean C., Hauser, Elizabeth R., Hauser, Michael A., Kimbrel, Nathan A., Lindquist, Jennifer H., McMahon, Benjamin, Oslin, David W., Qin, Xuejun, Agerbo, Esben, Børglum, Anders D., Breen, Gerome, Erlangsen, Annette, Esko, Tõnu, Gelernter, Joel, Hougaard, David M., Kessler, Ronald C., Kranzler, Henry R., Li, Qingqin S., Martin, Nicholas G., McIntosh, Andrew M., Mors, Ole, Nordentoft, Merete, Olsen, Catherine M., Porteous, David, Ursano, Robert J., Wasserman, Danuta, Werge, Thomas, Whiteman, David C., Bulik, Cynthia M., Coon, Hilary, Demontis, Ditte, Docherty, Anna R., Kuo, Po-Hsiu, Lewis, Cathryn M., Mann, J. John, Rentería, Miguel E., Smith, Daniel J., Stahl, Eli A., Stein, Murray B., Streit, Fabian, Willour, Virginia, and Ruderfer, Douglas M.

Abstract

BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.

Published
2022
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176. Mediating Effects of Neural Targets on Depression, Weight, and Anxiety Outcomes of an Integrated Collaborative Care Intervention: The ENGAGE-2 Mechanistic Pilot Randomized Clinical Trial

Author

Lv, Nan, primary, Ajilore, Olusola A., additional, Xiao, Lan, additional, Venditti, Elizabeth M., additional, Lavori, Philip W., additional, Gerber, Ben S., additional, Snowden, Mark B., additional, Wittels, Nancy E., additional, Ronneberg, Corina R., additional, Stetz, Patrick, additional, Barve, Amruta, additional, Shrestha, Rohit, additional, Dosala, Sushanth, additional, Kumar, Vikas, additional, Eckley, Tessa L., additional, Goldstein-Piekarski, Andrea N., additional, Smyth, Joshua M., additional, Rosas, Lisa G., additional, Kannampallil, Thomas, additional, Zulueta, John, additional, Suppes, Trisha, additional, Williams, Leanne M., additional, and Ma, Jun, additional

Published
2022
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177. sj-pdf-1-cpx-10.1177_21677026211057554 ��� Supplemental material for Moral Injury, Traumatic Stress, and Threats to Core Human Needs in Health-Care Workers: The COVID-19 Pandemic as a Dehumanizing Experience

Author

Hagerty, Sarah L. and Williams, Leanne M.

Subjects
FOS: Psychology, 170199 Psychology not elsewhere classified, humanities
Abstract

Supplemental material, sj-pdf-1-cpx-10.1177_21677026211057554 for Moral Injury, Traumatic Stress, and Threats to Core Human Needs in Health-Care Workers: The COVID-19 Pandemic as a Dehumanizing Experience by Sarah L. Hagerty and Leanne M. Williams in Clinical Psychological Science

Published
2022
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179. Associations between mental wellbeing and fMRI neural bases underlying responses to positive emotion in a twin sample.

Author

Park, Haeme R.P., Chilver, Miranda R., Montalto, Arthur, Jamshidi, Javad, Schofield, Peter R., Williams, Leanne M., and Gatt, Justine M.

Subjects
NEURAL physiology, WELL-being, STATISTICS, PREFRONTAL cortex, NEURAL pathways, GENETICS, HAPPINESS, MULTIVARIATE analysis, MAGNETIC resonance imaging, BRAIN mapping, TWINS, SOCIAL factors, FUNCTIONAL connectivity, FACIAL expression, SOCIAL context, EXPERIENCE, QUESTIONNAIRES, DESCRIPTIVE statistics, RESEARCH funding, EMOTIONS, STATISTICAL models, OPTIMISM
Abstract

Background: Although mental wellbeing has been linked with positive health outcomes, including longevity and improved emotional and cognitive functioning, studies examining the underlying neural mechanisms of both subjective and psychological wellbeing have been sparse. We assessed whether both forms of wellbeing are associated with neural activity engaged during positive and negative emotion processing and the extent to which this association is driven by genetics or environment. Methods: We assessed mental wellbeing in 230 healthy adult monozygotic and dizygotic twins using a previously validated questionnaire (COMPAS-W) and undertook functional magnetic resonance imaging during a facial emotion viewing task. We used linear mixed models to analyse the association between COMPAS-W scores and emotion-elicited neural activation. Univariate twin modelling was used to evaluate heritability of each brain region. Multivariate twin modelling was used to compare twin pairs to assess the contributions of genetic and environmental factors to this association. Results: Higher levels of wellbeing were associated with greater neural activity in the dorsolateral prefrontal cortex, localised in the right inferior frontal gyrus (IFG), in response to positive emotional expressions of happiness. Univariate twin modelling showed activity in the IFG to have 20% heritability. Multivariate twin modelling suggested that the association between wellbeing and positive emotion-elicited neural activity was driven by common variance from unique environment (r = 0.208) rather than shared genetics. Conclusions: Higher mental wellbeing may have a basis in greater engagement of prefrontal neural regions in response to positive emotion, and this association may be modifiable by unique life experiences. [ABSTRACT FROM AUTHOR]

Published
2023
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194. Accelerated neuromodulation therapy for Obsessive-Compulsive Disorder

Author

Williams, Nolan R., Sudheimer, Keith D., Cole, Eleanor J., Varias, Andrea D., Goldstein-Piekarski, Andrea N., Stetz, Patrick, Lombardi, Anthony, Filippou-Frye, Maria, van Roessel, Peter, Anderson, Kelley, McCarthy, Elizabeth A., Wright, Brianna, Sandhu, Thasveen, Menon, Sindu, Jo, Booil, Koran, Lorrin, Williams, Leanne M., and Rodriguez, Carolyn I.

Published
2021
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