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153. Contributors

Author

Adler, Stuart P., primary, Alford, Charles A., additional, Arvin, Ann M., additional, Baker, Carol J., additional, Barnett, Elizabeth D., additional, Bendel, Catherine M., additional, Bortolussi, Robert, additional, Bradley, John S., additional, Britt, William, additional, Cherry, James D., additional, Cleary, Thomas G., additional, Cooper, Louis Z., additional, D’Angio, Carl T., additional, Darville, Toni, additional, Davies, Jill K., additional, Desmonts, Georges, additional, Edwards, Morven S., additional, Embree, Joanne E., additional, Garofalo, Roberto P., additional, Gerber, Michael A., additional, Gershon, Anne A., additional, Gibbs, Ronald S., additional, Gutierrez, Kathleen M., additional, Hardy, R. Doug, additional, Heath, Joan A., additional, Ingall, David, additional, Klein, Jerome O., additional, Koch, William C., additional, Lewis, David B., additional, Long, Sarah S., additional, Mailman, Timothy L., additional, Maldonado, Yvonne A., additional, McCracken, George H., additional, McLeod, Rima, additional, McMillan, Julia A., additional, Miller, Michael J., additional, Nataro, James P., additional, Nizet, Victor, additional, Ogra, Pearay L., additional, Orscheln, Rachel C., additional, O’Ryan, Miguel L., additional, Overturf, Gary D., additional, Palazzi, Debra L., additional, Ramilo, Octavio, additional, Rassin, David K., additional, Remington, Jack S., additional, Sáez-Llorens, Xavier, additional, St. Geme, Joseph W., additional, Sanchez, Pablo J., additional, Shapiro, Eugene D., additional, Shinefield, Henry R., additional, Stagno, Sergio, additional, Starke, Jeffrey R., additional, Stoll, Barbara J., additional, Thulliez, Philippe, additional, Weinberg, Geoffrey A., additional, Whitley, Richard J., additional, Wilson, Christopher B., additional, and Zerr, Danielle M., additional

Published
2006
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161. Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease

Author

Kimberlin, David W., Acosta, Edward P., Sanchez, Pablo J., Sood, Sunil, Agrawal, Vish, Homans, James, Jacobs, Richard F., Lang, David, Romero, Jose R., Griffin, Jill, Cloud, Gretchen A., Lakeman, Fred D., and Whitley, Richard J.

Subjects
Valganciclovir -- Dosage and administration, Valganciclovir -- Research, Cytomegalovirus infections -- Care and treatment, Pharmacology, Experimental -- Reports, Infants (Newborn) -- Diseases, Infants (Newborn) -- Care and treatment, Health
Published
2008

168. Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system

Author

Bradford, Russell D., Cloud, Gretchen, Lakeman, Alfred D., Boppana, Suresh, Kimberlin, David W., Jacobs, Richard, Demmler, Gail, Sanchez, Pablo, Britt, William, Soong, Seng-jaw, and Whitley, Richard J.

Subjects
Infants (Newborn) -- Health aspects, Hearing disorders -- Research, DNA polymerases -- Research, Cytomegalovirus infections -- Diagnosis, Cytomegalovirus infections -- Research, Health
Published
2005

171. Effect of adenine arabinoside on severe Herpesvirus hominis infections in man

Author

Ch'ien, Lawrence T., Cannon, Nassif J., Charamella, Leigh J., Dismukes, William E., Whitley, Richard J., Buchanan, Robert A., and Alford, Charles A., Jr.

Subjects
Adenine -- Research, Herpesvirus diseases -- Research, Herpesvirus diseases -- Care and treatment, Herpesvirus diseases -- Drug therapy, Herpes -- Research, Herpes -- Care and treatment, Herpes -- Drug therapy, Health
Published
2004

173. Herpes Zoster

Author

Gnann, John W. and Whitley, Richard J.

Published
2003

176. A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase

Author

Saag, Michael S., Emini, Emilio A., Laskin, Oscar L., Douglas, Jeffrey, Lapidus, William I., Schleif, William A., Whitley, Richard J., Hildebrand, Carol, Byrnes, Vera W., Kappes, John C., Anderson, Kevin W., Massari, Ferdinand E., and Shaw, George M.

Subjects
HIV infection -- Care and treatment, Antiviral agents -- Structure-activity relationships
Abstract

The pyridinone non-nucleoside reverse transcriptase inhibitor L-967,661 shows significant dose-related activity against HIV-1 and is also well tolerated by patients, but the rapid emergence of resistant strains of the virus may limit the effectiveness of this and other non-nucleoside reverse transcriptase inhibitors. The non-nucleoside reverse transcriptase inhibitors are atypical antiretroviral agents with selective activity in vitro against human immunodeficiency virus type 1 (HIV-1). They perform through direct inhibition of reverse transcriptase and are not incorporated into DNA. However, in vitro studies have indicated additive or synergistic activity between nucleoside and non-nucleoside antiretroviral agents. These agents may continue to be useful in combination regimens. When the genetic complexity of the virus is extensive and subpopulations of resistant virus are more probable, the use of non-nucleoside agents for very early infection or post-exposure prophylaxis may be especially beneficial.

Published
1993

177. Prevention of Hepatitis B in Adolescents

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., and Pickering, Larry K.

Published
2001

178. Natural History of Neonatal Herpes Simplex Virus Infections in the Acyclovir Era

Author

Kimberlin, David W., Lin, Chin-Yu, Jacobs, Richard F., Powell, Dwight A., Frenkel, Lisa M., Gruber, William C., Rathore, Mobeen, Bradley, John S., Diaz, Pamela S., Kumar, Mary, Arvin, Ann M., Gutierrez, Kathleen, Shelton, Mark, Weiner, Leonard B., Sleasman, John W., de Sierra, Teresa Murguía, Soong, Seng-Jaw, Kiell, Jan, Lakeman, Fred D., and Whitley, Richard J.

Published
2001

179. Safety and Efficacy of High-Dose Intravenous Acyclovir in the Management of Neonatal Herpes Simplex Virus Infections

Author

Kimberlin, David W., Lin, Chin-Yu, Jacobs, Richard F., Powell, Dwight A., Corey, Lawrence, Gruber, William C., Rathore, Mobeen, Bradley, John S., Diaz, Pamela S., Kumar, Mary, Arvin, Ann M., Gutierrez, Kathleen, Shelton, Mark, Weiner, Leonard B., Sleasman, John W., de Sierra, Teresa Murguía, Weller, Stephen, Soong, Seng-Jaw, Kiell, Jan, Lakeman, Fred D., and Whitley, Richard J.

Published
2001

180. Recommended Childhood Immunization Schedule-United States, January-December 2001

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., Pickering, Larry K., Chilton, Lance, Dowell, Scott F., Embree, Joanne, Myers, Martin G., Orenstein, Walter A., Patriarca, Peter A., Starke, Jeffrey R., Ledbetter, Edgar O., and Kim, Joann

Published
2001

181. Acyclovir: a decade later

Author

Whitley, Richard J. and Gnann, John W., Jr.

Subjects
Acyclovir -- Health aspects, Herpes -- Drug therapy
Abstract

Acyclovir has been used for approximately 10 years to treat patients with infections caused by herpes virus. It interferes with the replication of herpes simplex virus (HSV) and varicella-zoster virus, the virus that causes chickenpox. Several different forms of acyclovir are available. It has been effective for the treatment of patients with genital herpes, but not for those with oral herpes. Immunocompromised children with chickenpox are treated with acyclovir to prevent complications. It is also used to prevent cytomegalovirus disease in transplant recipients and to treat infections caused by Epstein-Barr virus. HSV and varicella-zoster virus can become resistant to acyclovir over time, especially in AIDS patients. Very few side effects have been reported for acyclovir, but it rarely may cause reversible kidney impairment and disturbances of the central nervous system.

Published
1992

182. Meningococcal Disease Prevention and Control Strategies for Practice-Based Physicians (Addendum: Recommendations for College Students)

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., Pickering, Larry K., Chilton, Lance, Dowell, Scott F., Embree, Joanne, Myers, Martin G., Orenstein, Walter A., Patriarca, Peter A., Starke, Jeffrey R., Ledbetter, Edgar O., Peter, Georges, and Kim, Joann

Published
2000

183. Technical Report: Precautions Regarding the Use of Aerosolized Antibiotics

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., Pickering, Larry K., Chilton, Lance, Dowell, Scott F., Embree, Joanne, Myers, Martin G., Orenstein, Walter A., Patriarca, Peter A., Starke, Jeffrey R., Ledbetter, Edgar O., Kim, Joann, Ward, Robert M., Bates, Brian A., Benitz, William E., Burchfield, David J., Ring, John C., Walls, Richard P., Walson, Philip D., Bennett, Donald R., Cvetkovich, Therese, Hagino, Owen R., MacLeod, Stuart M., Mithani, Siddika, Mulinare, Joseph, Riley, Laura E., Yaffe, Sumner J., Coté, Charles J., Meltzer, Eli O., Campbell, Preston, Jones, Jim, and Koteras, Raymond J.

Published
2000

184. Technical Report: Transmissible Spongiform Encephalopathies: A Review for Pediatricians

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., Peter, Georges, Pickering, Larry K., MacDonald, Noni E., Chilton, Lance, Delage, Gilles, Dowell, Scott F., Jacobs, Richard F., Myers, Martin G., Orenstein, Walter A., Patriarca, Peter A., and Ledbetter, Edgar O.

Published
2000

185. Technical Report: Prevention of Pneumococcal Infections, Including the Use of Pneumococcal Conjugate and Polysaccharide Vaccines and Antibiotic Prophylaxis

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., Peter, Georges, Pickering, Larry K., MacDonald, Noni E., Chilton, Lance, Jacobs, Richard F., Delage, Gilles, Dowell, Scott F., Orenstein, Walter A., Patriarca, Peter A., Myers, Martin G., Ledbetter, Edgar O., and Kim, Joann

Published
2000

186. Policy Statement: Recommendations for the Prevention of Pneumococcal Infections, Including the Use of Pneumococcal Conjugate Vaccine (Prevnar), Pneumococcal Polysaccharide Vaccine, and Antibiotic Prophylaxis

Author

Abramson, Jon S., Baker, Carol J., Fisher, Margaret C., Gerber, Michael A., Meissner, H. Cody, Murray, Dennis L., Overturf, Gary D., Prober, Charles G., Rennels, Margaret B., Saari, Thomas N., Weiner, Leonard B., Whitley, Richard J., Peter, Georges, Pickering, Larry K., MacDonald, Noni E., Chilton, Lance, Delage, Gilles, Dowell, Scott F., Jacobs, Richard F., Myers, Martin G., Orenstein, Walter A., Patriarca, Peter A., and Ledbetter, Edgar O.

Published
2000

187. A controlled trial of acyclovir for chickenpox in normal children

Author

Dunkle, Lisa M., Arvin, Ann M., Whitley, Richard J., Rotbart, Harley A., Feder, Henry M., Jr., Feldman, Sandor, Gershon, Anne A., Levy, Moise L., Hayden, Gregory F., McGuirt, Paul V., Harris, Janna, and Balfour, Henry H., Jr.

Subjects
Acyclovir -- Usage, Chickenpox -- Drug therapy, Chickenpox -- Complications
Abstract

Chickenpox is one of the more common childhood diseases. It is caused by the varicella-zoster virus. About 3.5 million cases of chickenpox are thought to occur in the US each year; about 4,500 patients require hospitalization. Complications are not common, but chickenpox may lead to secondary bacterial infection of the skin, inflammation of the lungs, cerebellar ataxia (an abnormality of gait resulting from effects on the cerebellum), and encephalitis. The death rate for otherwise healthy children with chickenpox is about 1 in 50,000. The antiviral drug acyclovir has been used successfully to treat varicella infections in normal adults and immunocompromized patients. A study has now been conducted to evaluate the effectiveness of acyclovir in treating normal children with chickenpox. A total of 815 children with chickenpox were randomly assigned to receive treatment with acyclovir or placebo within the first 24 hours of the appearance of the symptomatic "pocks". The children treated with acyclovir had fewer lesions than the children treated with placebo, with an average of 294 versus 347 lesions, respectively. Furthermore, over 95 percent of the children treated with acyclovir stopped developing new skin lesions by the fourth day of infection. In contrast, one-fifth of the placebo-treated children continued to develop new lesions after day five. Four children in the acyclovir group and six in the placebo group developed bacterial infections as a complication of chicken pox. One case of cerebellar ataxia was noted in the placebo group. The incidence of complications was too small, however, to draw any conclusions. Although the results clearly show that acyclovir reduces the severity and the duration of chickenpox, it remains uncertain if the rate of complications is also decreased by acyclovir treatment. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

189. Mapping of herpes simplex virus-1 neurovirulence to gamma-1 34.5, a gene nonessential for growth in culture

Author

Chou, Joany, Kern, Earl R., Whitley, Richard J., and Roizman, Bernard

Subjects
Virulence (Microbiology) -- Research -- Genetic aspects, Herpes simplex virus -- Genetic aspects -- Research, Chromosome mapping -- Research -- Genetic aspects, Science and technology, Research, Genetic aspects
Abstract

The gene disignated [γ.sub.1]34.5 maps in the inverted repeats flanking the long unique sequence of herpes simplex virus-1 (HSV-1) DNA, and therefore it is present in two copies per genome. [...]

Published
1990

190. Medical progress: viral encephalitis

Author

Whitley, Richard J.

Subjects
Encephalitis -- Causes of, Encephalomyelitis -- Research, Brain -- Inflammation
Abstract

In a review of viral encephalitis, author Richard J. Whitley discusses the many aspects of this disease. More precisely, he discusses the aspects of these diseases, since a wide variety of different viruses may infect the brain. Some, like rabies, essentially affect only the brain; most encephalitis is the result of a common virus, like herpes simplex or measles, which infects the brain only occasionally. Different viruses take different routes into the brain, but most are carried by the blood, and are often transmitted by a mosquito. It is not always clear how viruses cross the blood-brain barrier, which protects the brain from unwanted elements in the blood. Recently the AIDS virus has joined the ranks of viruses infecting the brain. While the pathological picture is different from classic encephalitis viruses like herpes simplex, AIDS encephalitis manages to produce dementia in virtually all patients by the time of death. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

193. Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice

Author

Bernstock, Joshua D., primary, Vicario, Nunzio, additional, Li, Rong, additional, Nan, Li, additional, Totsch, Stacie K., additional, Schlappi, Charles, additional, Gessler, Florian, additional, Han, Xiaosi, additional, Parenti, Rosalba, additional, Beierle, Elizabeth A., additional, Whitley, Richard J., additional, Aban, Inmaculada, additional, Gillespie, G. Yancey, additional, Markert, James M., additional, and Friedman, Gregory K., additional

Published
2019
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197. Pharmacokinetics of oral valacyclovir and acyclovir in late pregnancy

Author

Kimberlin, Debora F., Weller, Stephen, Whitley, Richard J., Andrews, William W., Hauth, John C., Lakeman, Fred, and Miller, Gerri

Subjects
Herpes genitalis -- Drug therapy, Acyclovir -- Evaluation, Pregnancy, Health
Abstract

Acyclovir therapy was compared to the acyclovir prodrug valacyclovir in pregnant women with a history of genital herpes simplex infection. Pharmacokinetic profiles were established after the 36th week of pregnancy, the onset of drug therapy. Ten women who took a daily dose of 1,000 mg of valacyclovir had higher concentrations of the drug in their blood than the ten women who received 1,200 mg of acyclovir. Overall, valacyclovir appeared to be non-toxic and was well tolerated.

Published
1998

198. Guidelines for the Treatment of Cytomegalovirus Diseases in Patients With AIDS in the Era of Potent Antiretroviral Therapy: Recommendations of an International Panel

Author

Whitley, Richard J., Jacobson, Mark A., Friedberg, Dorothy N., Holland, Gary N., Jabs, Douglas A., Dieterich, Douglas T., Hardy, W. David, Polis, Michael A., Deutsch, Thomas A., Feinberg, Judith, Spector, Stephen A., Walmsley, Sharon, Drew, W. Lawrence, Powderly, William G., Griffiths, Paul D., Benson, Constance A., and Kessler, Harold A.

Published
1998

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