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Synchronous condenser is a good reactive power compensation equipment in power grid. In recent years, with the development of UHVDC transmission, the characteristics of "Strong HVDC and Weak AC" in the power grid have become more and more obvious, so the demand for reactive power compensation is also increasing. Compared with SVC and SVG, synchronous condenser has a larger reactive power compensation capacity, and its reactive power compensation status is getting higher and higher. The reactive power compensation characteristics of synchronous condenser are determined by the characteristics of its excitation power supply. In this paper, a high and low voltage switching type high-precision excitation power supply is designed, its principle is introduced, and the simulation analysis is carried out in PSIM simulation software. Finally, a 1kW low power device is developed and designed to carry out experimental verification.

Pumped-storage unit (PSU) often acts as the peak and frequency modulation sources in modern power systems. The frequent operation condition conversions and tight hydraulic couplings with conduit system make its governing control a tough work in practise. To overcome the difficulty in the proportional–integral–derivative (PID) parameter tuning during transient processes, a hierarchical model predictive control (MPC) scheme, in which constrained generalised predictive control (CGPC) cooperates with classic PID is proposed. In the upper hierarchy of the MPC controller, CGPC acts as an auxiliary optimiser for the optimal PID parameters through online optimisation, whereas in the lower hierarchy, PID directly steers the movements of servomotor to control the guide vane opening; thus, to match the existing governing equipment in engineering practise. Also, typical constraints on the input/output signals and value ranges of PID parameters are discussed. Simulation experiments are conducted on a non-linear distributed-parameter simulation platform. It can precisely reflect hydraulic and mechanical dynamic behaviours of PSU and its conduit system. The results indicate that the proposed hierarchical MPC scheme not only outperforms in speed tracking and oscillation damping, but also attenuate instability phenomena caused by the negative ‘S’ character in pump turbine.

Monodispersed hairy nanocomposites with typical 2 nm (isophthalic acid)24 Cu24 metal-organic polyhedra (MOP) as a core protected by 24 polymer chains with controlled narrow molecular weight distribution has been probed by imaging and scattering studies for the heterogeneity of polymers in the nanocomposites and the confinement effect the MOPs imposing on anchored polymers. Typical confined-extending surrounded by one entanglement area is proposed to describe the physical states of the polymer chains. This model dictates the counterintuitive thermal and rheological properties and prohibited solvent exchange properties of the nanocomposites, whilst those polymer chain states are tunable and deterministic based on their component inputs. From the relationship between the structure and behavior of the MOP nanocomposites, a MOP-composited thermoplastic elastomer was obtained, providing practical solutions to improve mechanical/rheological performances and processabilities of inorganic MOPs.

The aim of this study is to investigate the functions and mechanisms of miR‐608 in prostate cancer (PCa). CISH and qRT‐PCR analysis demonstrated that miR‐608 was low expressed in PCa tissues and cells, which was partly attributed to the methylation of CpG island adjacent to the transcription start site (TSS) of miR‐608 gene. Intracellular miR‐608 overexpression inhibited in vivo PCa tumor growth, and suppressed PCa cell proliferation, G2/M transition, and migration in vitro, which was independent of EMT‐associated mechanisms. Then RAC2, a GTPase previously deemed hematopoiesis‐specific but now discovered to exist and play important roles in PCa, was verified by western blot and dual‐luciferase reporter assays to mediate the effects of miR‐608 through RAC2/PAK4/LIMK1/cofilin pathway. MiR‐608 also promoted the apoptosis of PCa cells through BCL2L1/caspase‐3 pathway by targeting the 3′‐UTR of BCL2L1. Moreover, PAK4, the downstream effector of RAC2, was found to be targeted by miR‐608 at the mRNA coding sequence (CDS) instead of the canonical 3′‐UTR. Knocking down RAC2, PAK4, or BCL2L1 with siRNAs reproduced the antiproliferative, mitosis‐obstructive, antimigratory and proapoptotic effects of miR‐608 in PCa cells, which could be attenuated by downregulating miR‐608. In conclusion, miR‐608 suppresses PCa progression, and its activation provides a new therapeutic option for PCa.

Thermoplastic elastomers (TPEs) have found use in a wide range of applications, such as adhesives, elastomers, coatings, fibers, and in additive manufacturing techniques such as 3D printing. Despite their omnipresence, the need for advanced TPEs with adaptive properties is continuously growing. Along with a brief historical introduction, this review presents an overview of typical structure-property relationships for various TPEs and discusses the design principles of TPEs from a synthetic chemistry perspective. Recent advances in TPEs with different macromolecular architectures, including linear ABA triblock copolymers, ABC triblock terpolymers, multiblock copolymers, star copolymers, graft copolymers, bottlebrush polymers, and hyperbranched polymers are reviewed. Service temperatures and mechanical properties of the different materials are compared in each section. Incorporating various supramolecular interactions into different macromolecular architectures as a means to further extend the range of TPE applications is also discussed. Future opportunities for TPE research in both academia and industry are addressed as perspectives.

Here, we report two novel enteroviruses, designated as SD-S67 and SD-S68, isolated from a goat farm. Their complete genome sequences were determined and found to be 7455 and 7465 nucleotides in length, respectively. Molecular characterization revealed that SD-S67 is closely related to bovine enterovirus strain 261 and that SD-S68 to caprine enterovirus strain CEV-JL14. Phylogenetic analysis showed that SD-S67 clustered with members of the species Enterovirus F, and that SD-S68 clustered with enteroviruses of goats and sheep. Recombination analysis showed that SD-S67 is likely to have undergone several recombination events in the process of its evolution. To the best of our knowledge, this is the first report of an enterovirus F isolate from a goat and of a coinfection with enteroviruses of different species in the same goat herd.

A new method, “nonvolatile solvent vapor annealing” (NVASA), has been developed to anneal block copolymers during film deposition by controlling the solvent drying process. Precise amounts of high ...

We carried out a large set of tests to establish a correlation between the molecular (network) structure (influenced by molecular weight, molecular weight distribution, and melt predeformation) and mechanical responses of several glassy polymers to uniaxial compression at different temperatures and different compression speeds. The experimental results show that to have ductile responses there must be an adequate chain network, afforded by the interchain uncrossability among sufficiently long chains. Specifically, polystyrene (PS) and poly(methyl methacrylate) of sufficiently low molar mass do not have chain network and are found to be very brittle. Binary PS mixtures are brittle at room temperature when the volume fraction of the high‐molecular‐weight component is sufficiently low (e.g., at and below 27.5%). Moreover, sufficiently melt‐stretched PS mixtures show brittle fracture when compressed along the same direction, along which melt stretching was made. All the experimental findings confirm that a robust chain network is also a prerequisite for yielding and ductile cold compression of polymer glasses, as is for extension. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 758–770

The stability problems of the hydroelectric generating unit caused by the vibration of the runner blades have been gradually exposed in the long-term operation, especially in the hydropower stations equipped with the bulb turbine. However, in the previous studies, the effects of the blades were not considered. Aiming at these problems, this research will be focused on studying the dynamic characteristics of the bulb hydroelectric generating unit in consideration with the effects of blades. Firstly, a novel continuum shaft system model of the bulb hydroelectric generating unit is originally established considering the effects of the blades. Meanwhile, the rationality of the novel model is verified by comparing with the field test data. Then, the dynamic evolutions of the shaft system with and without blades are contrastively analyzed and discussed with the changing of the runner mass eccentricity, the seal gap, the rotational speed and the exciting current. Fortunately, some critical values and stability evolution characteristics of the shaft system are obtained. In addition, the effects of the blades are also found. More importantly, these results could provide a reference for the safe operation of the hydropower stations.

Undesirable pressure pulsations will be induced by flow instabilities in the draft tube when the Francis turbine operates at off-design conditions, which have multiple effects on the steady operation, and the effects vary with the operating condition. Therefore, the establishment of a comprehensive state evaluation index of the draft tube pressure pulsation (DTPP) is of great practical significance. In this study, a comprehensive evaluation method of DTPP has been proposed based on Ensemble Empirical Mode Decomposition (EEMD) and information entropy. First, the frequency components of DTPP are separated by the EEMD method which is more suitable for the analysis of non-stationary pressure pulsation signal. Second, to eliminate the effects of noise, a targeted EEMD noise reduction method which is combined with autocorrelation analysis and wavelet soft-threshold de-noising method is designed for the DTPP signal. Then, index energy values of all frequency components are calculated and normalized, and the values of the signals’ characteristic entropy are obtained by using the normalized index energy vector as the input vector. Finally, characteristic entropy values of all pressure pulsation signals measured from the draft tube are integrated into an index, which is named as the comprehensive characteristic entropy of DTPP (E_DTPP). The state of DTPP is comprehensively evaluated by E_DTPP. This method was evaluated by the actual measuring data of a 200 MW hydroelectric generating unit. The case study indicates that this single index can be utilized to evaluate the actual state of DTPP, and pressure pulsations will have distinct influence on the operation stability when E_DTPP increases obviously. The efforts of this study provide a novel and useful method for the comprehensive state evaluation of DTPP, and the E_DTPP could be used as an index for the stability of Francis turbine.

This study investigates the impact of wind spatial distribution on sub-synchronous resonance (SSR), considering wind speed difference and wind turbine division. For a doubly-fed induction generator (DFIG) wind farm, two equivalent aggregated models, i.e. a one-DFIG model and a multi-DFIG model, are established and both simplified to impedance model for investigation. In one-DFIG model, the SSR mechanism in DFIG wind farm, and the impact of wind speed on SSR are discussed. The concept of damping is introduced to explain how DFIG SSR current changes under the negative resistance of wind farm. Then, in multi-DFIG model, DFIGs are divided into different groups based on their wind speed, and the interaction between DFIG groups is investigated. Simulations are used to validate the proposed analysis, and the results show that, multi-DFIG model performances a higher accuracy when dealing with DFIG wind spatial distribution problems compared with one-DFIG model.

In this paper, a transient stability prediction method based on deep belief network (DBN) and long short-term memory (LSTM) network is proposed. DBN is utilized to embed the original transient stability data into a low-dimensional representation space and assess transient stability preliminarily. Owing to the good performance of LSTM networks in extracting the features of time series for a longtime span, it is utilized to predict generator rotor angle trajectory of instability samples, which can identify the unstable generator in advance. The proposed method is validated by IEEE New England 39-bus system. Simulation results show that the proposed method has the merits of quickness and accuracy criteria and can provide guidelines for online monitoring of power system stability.

In North-west china, the soybean (Glycine max L. Merr.) is grown in June, when the climate is dry, and soil has limited moisture contents. Moisture deficiency limits the soybean biomass. We studied the effects of wheat straw mulching and nitrogen on soybean growth, physiology and soil properties in three-year field experiments. The treatments included three straw mulching i.e. S1 (0 kg ha−1), S2 (3000 kg ha−1) and S3 (6000 kg ha−1), and three nitrogen rates i.e. N1 (0 kg N ha−1), N2 (21.6 kg N ha−1), and N3 (27 kg N ha−1). Full mulching (S3) significantly increased moisture retention (7.4%) and decrease soil temperature (3.0%) in 0–20 cm soil depth, increased photosynthesis, SPAD-value, leaf area, leaf area index, growth, and soybean grain yield (20.8%) over no-mulching (S1). The S3 improved the roots mass, nodules number and weight than S1. The application of 27 kg N ha−1 or 100% N fertilizer (N3) had significantly increased photosynthesis, SPAD-value, growth, and biomass and seed yield of soybean over no-N application (N1). It was concluded that using straw mulching (6 Mg ha−1) can change the soil hydrothermal regime for provision of favorable condition for soybean growth when 27 kg N ha−1 was used in semi-arid condition of North-west China.

The exponential advancement in artificial intelligence (AI), machine learning, robotics, and automation are rapidly transforming industries and societies across the world. The way we work, the way we live, and the way we interact with others are expected to be transformed at a speed and scale beyond anything we have observed in human history. This new industrial revolution is expected, on one hand, to enhance and improve our lives and societies. On the other hand, it has the potential to cause major upheavals in our way of life and our societal norms. The window of opportunity to understand the impact of these technologies and to preempt their negative effects is closing rapidly. Humanity needs to be proactive, rather than reactive, in managing this new industrial revolution. This article looks at the promises, challenges, and future research directions of these transformative technologies. Not only are the technological aspects investigated, but behavioral, societal, policy, and governance issues are reviewed as well. This research contributes to the ongoing discussions and debates about AI, automation, machine learning, and robotics. It is hoped that this article will heighten awareness of the importance of understanding these disruptive technologies as a basis for formulating policies and regulations that can maximize the benefits of these advancements for humanity and, at the same time, curtail potential dangers and negative impacts.

112 Gbps per wavelength, amplification free Four-level Pulse Amplitude Modulation (PAM-4) transmissions are experimentally demonstrated with advanced digital signal processing (DSP) algorithms. Two DSP architectures are investigated for Directly Modulated Lasers (DMLs): 1) the regular DSP with Feed Forward Equalization (FFE) and Decision Feedback Equalization (DFE), and 2) the enhanced DSP with Maximum Likelihood Sequence Estimation (MLSE) equalizer. The experimental results show that with advanced DSP technologies the conventional DML can achieve 40 km transmissions with Bit Error Rate (BER) under 2.4 × 10−4 that meets RS (544, 514) Forward Error Correction (FEC) requirement; with regular-DSP the advanced DML can achieve 40 km transmissions with BER under 3.8 × 10−3, with stronger FEC. 112 Gbps and beyond per lambda DML based transmission is a promising low power, low-cost solution for 800 GbE or 1.6 TbE Ethernet.

This paper explores the connection between lesbian internet celebrities and their audiences. Under the circumstance of the burgeoning market on social media platforms in mainland China, I take Xiaohongshu (Little Red Book), a social media platform that is permeated by female users as a study target. In addition, I use Manxue, Maxxxx, and Quanjiaofu as lesbian internet celebrities' examples. I examined whether previous studies shed light on the internet celebrity-audience relationship still suits lesbian internet celebrity-audience relationships. Considering that in the context of mainland China, homosexuals such as lesbians are not welcomed by mainstream media and undergo serious censorship when posting content on social media. This study invited 26 female users who identified themselves as lesbians or bisexuals to participate in online and offline interviews. Former studies centered on T-style (Tomboy style) fandom enlightened the direction of this study. Although the appearance of lesbian internet celebrities is evaluated by the audience when they make decisions if they will start to follow or not, the essential part which prolongs the connectedness between them and the lesbian internet celebrity is the genuine attitude they believe they are receiving from the internet celebrity. Similar life backgrounds such as being a sexual minority or outrageous performance might have a chance to win the glances of users when they scroll the screen. According to the interview results, sincere life sharing and self-disclose storytelling bring the two sides closer and cultivate intimacy and affinity which help to strengthen the bond between lesbian internet celebrities and audiences.

Although gastric surgery can significantly improve blood glucose homeostasis in type 2 diabetes mellitus (T2DM), its mechanism remains unclear. This study evaluated the role of intestinal glucose sensing, glucose transport, and metabolism in the alimentary limb (A limb) of T2DM rats after duodenal jejunal bypass (DJB) surgery.A T2DM rat model was induced via a high-glucose high-fat diet and low-dose streptozotocin injection. The diabetic rats were divided into two groups: the DJB surgery (T2DM-DJB) group and the sham surgery (T2DM-Sham) group. Wistar rats were used as wild-type control (Control). Small animal PET was used to assess the change in glucose metabolic status in the intestine. The intestinal villi height and the number of EECs after DJB were evaluated. The expressions of sweet taste receptors (T1R2/T1R3), glucose transporters (SGLT1/GLUT2), and key enzymes involved in glucose metabolism (HK2, PFK2, PKM2, G6Pase, and PCK1) in the A limb after DJB was detected by Western blot and qRT-PCR.Small animal PET analysis showed the intestinal glucose metabolism increased significantly 6 weeks after DJB surgery. The intestinal villi height and the number of EECs in the A limb 6 weeks after surgery increased significantly in T2DM-DJB rats comparing to T2DM-Sham rats. The mRNA and protein expression of T1R1/T1R3 and SGLT1/GLUT2 were downregulated in DJB-T2DM rats, while enzymes involved in glucose metabolism was upregulated in the A limb in T2DM-DJB rats.Proximal intestinal glucose sensing and metabolism play an important role in blood glucose homeostasis by DJB.

Objective National averages obscure geographic variation in program performance. We determined Parliamentary Constituency (PC)‐wise estimates of TB notification to guide political engagement. Methods We extracted district‐level TB notification data from the 2018 annual TB report. We derived PC‐level estimates by building a ‘cross‐walk’ between districts and PCs using boundary shapefiles. We described the spatial distribution of the PC‐wise estimates of Total Notification Rate and percentage of Private Sector Notification. Results The median PC‐wise Total Notification Rate was 126.24/100 000 (IQR: 94.86/100 000, 162.22/100 000). The median PC‐wise Percentage Private Sector Notification was 18.03% (IQR: 9.56%, 26.84%). Only 16 (2.94%) PCs met the target of 50% private sector notification. Most of high notification rates in PCs were driven by high notification in public sector. There was geographic – both interstate and within state inter‐PC – variation in the estimates of these indicators. The study identified some geographic patterns of notification – high positive outlier PCs with adjoining PCs in lower deciles of notification rates, intra‐state differences in PC performance, and similarities in notification rates of adjoining PCs in different states. Conclusion In addition to regional inequality, the study identified geospatial patterns that can aid in the formulation of suitable interventions. These include decongestion of overburdened facilities by strengthening poorly performing units. The PCs with a high percentage Private Sector Notification can act as role models for neighbouring PCs to improve private sector engagement. MPs can play a crucial role in mobilising additional resources, creating awareness, and establishing inter‐PC and inter‐state collaboration to improve TB program performance.

BackgroundTumor-associated macrophages (TAMs) are the major immune cells in tumor microenvironment. The prognostic significance of TAMs has been confirmed in various tumors. However, whether TAMs can be prognostic factors in clear cell renal cell carcinoma (ccRCC) is unclear. In this study, we aimed to clarify the prognostic value of TAMs in ccRCC.MethodsWe searched PubMed, Embase, and the Web of Science for relevant published studies before December 19, 2020. Evidence from enrolled studies were pooled and analyzed by a meta-analysis. Hazard ratios (HRs) and odd ratios (ORs) with 95% confidence intervals (CIs) were computed to evaluate the pooled results.ResultsBoth of high CD68+ TAMs and M2-TAMs were risk factors for poor prognosis in ccRCC patients. The pooled HRs indicated that elevated CD68+ TAMs correlated with poor OS and PFS (HR: 3.97, 95% CI 1.39–11.39; HR: 5.73, 95% CI 2.36–13.90, respectively). For M2-TAMs, the pooled results showed ccRCC patients with high M2-TAMs suffered a worse OS and shorter PFS, with HR 1.32 (95% CI 1.16–1.50) and 1.40 (95% CI 1.14–1.72), respectively. Also, high density of TAMs was associated with advanced clinicopathological features in ccRCC.ConclusionsTAMs could be potential biomarkers for prognosis and novel targets for immunotherapy in ccRCC. Further researches are warranted to validate our results.

Objective: To explore the advantages of continuous nursing for patients with advanced esophageal cancer after esophageal stent implantation. Methods: A total of 48 patients with advanced esophageal cancer who successfully received esophageal stent implantation in the Department of Oncology, at the First People’s Hospital Affiliated with Shanghai Jiao Tong University were divided into the control group (24 cases, receiving routine discharge guidance) and the experimental group (24 cases, receiving continuous nursing through the issuance of a home nursing instruction handbook, dietary transition guidance after discharge, nutrition and food evaluation, and guidance on daily activities, medication, and prevention of complications, etc.). The quality of life (EORTCQLQ-C30), nutritional status (MNA score and the levels of hemoglobin (Hb), serum total protein (TP) and albumin (Alb)), anxious/depressive mental state (HAMA, HAMD), complications and satisfaction were compared between the two groups. Results: EORTCQLQ-C30, HAMA and HAMD scores of the two groups three months after discharge were lower than those before discharge, and those of the experimental group were lower than those of the control group (all P0.05), while the MNA score and the levels of Hb, TP and Alb in the control group three months after discharge were lower than those before discharge and those in the experimental group (all P

A distributed cooperative control (DCC) strategy based on the consensus protocol is proposed for providing frequency support through voltage source converter based multi-terminal direct current transmission (VSC-MTDC) systems. The DCC consists of a local P - V droop controller and a cooperative agent network for cooperation control. Each agent controller is composed of a frequency regulation subagent (FRA) for frequency support and a load ratio subagent (LRA) for balancing the power sharing amongst the stations connected to the same ac grid. Moreover, to reduce the impact of the communication link failure, a topology evaluating method is proposed to select the suitable topology of the communication network via graph theory. The small signal stability analysis and the steady-state analysis are performed to investigate the stability and the consensus performance of the VSC-MTDC systems with DCC. Compared with decentralized control, the DCC can simultaneously achieve better frequency support and power sharing without leading to a large dc voltage deviation. The effectiveness of the DCC is verified by simulations on a hybrid ac/dc grid with a 7-terminal VSC-MTDC in DIgSILENT/PowerFactory under the load step change event and communication failure event.

214 Gbps per lane PAM-4 transmissions are demonstrated with 25 GHz class commercial EML. Employing an improved MLSE algorithm enables the system to meet 10 km transmission with under KP4-FEC BER threshold requirement. The experiment results show the potential of commercial EML for 800 GbE application.

e20521 Background: Lung adenocarcinoma (LUAD), at the cellular level, has a high degree of intratumor heterogeneity. Advanced single-cell sequencing technologies have offered tools to analyze intratumor heterogeneity and identify the biomarkers, thereby aiding cancer diagnosis and prediction of the patient prognosis. Methods: From the Gene Expression Omnibus (GEO) (www.ncbi.nlm.nih.gov/geo) database, the single-cell RNA sequencing (scRNA-seq) data from two LUAD and two para-cancerous tissue samples were obtained. We performed a dimensionality reduction and unsupervised clustering to identify the different cell clusters within the tumor tissues. To identify the most relevant modules and important cell subpopulations (clusters) in LUAD tissues, a weighted gene co-expression network analysis (WGCNA) was performed. Subsequently, we classified the LUAD molecular subtypes according to the marker genes of these clusters. The Limma package ( www.bioconductor.org/packages/release/bioc/html/limma ) was used to screen for the differentially expressed genes (DEGs) between the subtypes. Using univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses, the gene signature most significantly associated with the prognosis of LUAD patients was determined. Results: A total of 14 cell clusters belonging to 10 cell types in LUAD was identified. The turquoise module was found to be the most relevant to LUAD among all the modules; cluster 10 (C10) was found to be the most strongly associated with the turquoise module. In The Cancer Genome Atlas (TCGA), patients with LUAD were divided into two groups of distinct molecular subtypes. Based on the 165 shared genes between the turquoise module and C10, 511 DEGs between the two molecular subtypes were obtained, and five of them were selected to construct the gene signature, which was validated to be an independent prognostic marker of LUAD. Conclusions: 14 cell clusters co-existed in LUAD, which contributed to its intratumor heterogeneity. In addition, two molecular subtypes of LUAD were identified and a five-gene signature was developed and validated to be significantly associated with prognostic and clinical characteristics of LUAD patients. Keywords: single-cell RNA sequencing, lung adenocarcinoma, intratumor heterogeneity, molecular subtypes, prognosis, five-gene signature.

Retraction The abstract by Wu et al entitled, “Identification of Two Subtypes and Prognostic Characteristics of Lung Adenocarcinoma based on Pentose Phosphate Metabolic Pathway-related Long Non-Coding RNAs,” ( Journal of Clinical Oncology 40, no. 16, suppl e20531) published on June 1, 2022, has been retracted due to statistical errors that significantly changed the results and conclusion of the abstract. This abstract was retracted on November 4, 2022. e20531 Background: The most frequent histological lung cancer subtype associated with a high mortality rate is lung adenocarcinoma (LUAD). Thus, its typing is crucial for the assessment of patient characteristics. This study aimed to analyze the differences in subtypes and characteristics of advanced (Stage II, III, and IV) LUAD patients based on the pentose phosphate metabolic pathway-related long non-coding RNAs (lncRNAs), along with their potential regulatory mechanisms. Methods: Using the expression profiling and corresponding clinical information of LUAD patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA), single-sample gene set enrichment analysis (ssGSEA) was used to determine the scores for the metabolic pathways for all samples. In addition, differential pathway scores between normal and tumor samples from TCGA were identified by rank-sum tests. Prognosis-related metabolic pathways were identified by univariate Cox analyses for both datasets. Pearson correlation coefficients between PENTOSE PHOSPHATE scores of the pentose phosphate samples and the lncRNAs of the corresponding datasets were calculated. Next, a consistency matrix was constructed by consistency clustering and the samples were clustered and typed using the KM algorithm using euclidean as the metric distance. Next, the clusterProfiler software package was used for functional annotation. Finally, functional evaluation was performed by analysis of the transcription factor (TF) activity and first-order partial correlation computation. Results: By clustering pentose phosphate-related lncRNAs from LUAD samples, we obtained two molecular subtypes of LUAD, C1, and C2. The C1 subtype was associated with a lower PENTOSE PHOSPHATE score and a good prognosis; conversely, the C2 subtype showed a higher PENTOSEPHOSPHATE score and was related to poorer prognoses. The findings of the gene set enrichment analysis (GSEA) suggested that C2 was markedly associated with energy metabolic pathways. In addition, the levels of expression of most immune cells were markedly higher in the C1 subtype relative to the C2 subtype. Some crucial immune checkpoints, including CTLA4, CD274, and CD47, were also significantly upregulated in the C1 subtype, leading to a higher score for clinical effect in the C1 subtype. Finally, one TF, BACH1, was found to be significantly upregulated in C1 subtypes; the pathways activated by this TF may be associated with tumor progression and poor prognoses. Conclusions: Precise typing of LUAD based on pentose phosphate metabolic pathway-related lncRNAs was confirmed. The differences in the characteristics between C1 and C2 subtypes may contribute to a better understanding of LUAD, thus yielding new targets for detection and treatment.

Methicillin-resistant Staphylococcus (MRS) is a multi-drug resistant bacteria that pose a serious threat to human health. Antibacterial nanomaterials are becoming a promising antibiotic substitute or antibiotic adjuvants. In this work, selenium nanowires were modified with nano‑silver (Ag NPs) with antibacterial activity and [Ru(bpy)

Objective: While it is known that exercise therapy can improve physical and emotional function in cerebral infarction (CI) patients, few studies have examined how well this would be accepted by older adults in China. Methods: In this study, the feasibility of recruiting and assessing health-related quality of life and physical function in older Chinese adults with cerebral infarction was assessed. Specific aims of the study were to evaluate the feasibility of recruiting older adults, with and without CI, from three different locations/settings in China; Compare the quality of life and physical function measures between CI and control subjects; Propose future larger randomized controlled studies of aerobic and resistance exercise training in both human and animal models after CI. Results: Overall, 66/275 (24.0%) surveys that were sent to older Chinese adults were returned and evaluated. Of those surveys returned, 18 (27%) met the study inclusion and exclusion criteria. Consequently, the results of this feasibility study indicate there is a recruitment yield (number of subject contacted/number of subjects who qualified for study) of 6.5%. These number varied at the different sites/settings, but the highest recruitment yield was seen in hospitalized patients. Despite small sample sizes, there were statistically significant differences in health-related quality of life and physical function between CI patients and control subjects. Conclusion: This feasibility study demonstrated that it is possible to successfully recruit CI patients for an exercise intervention study as well as to perform important assessments of health-related quality of life and physical function. Further randomized controlled trials, in humans and animal models, will be needed determine if aerobic and/or resistance exercise training can improve health and physical function in older CI patients. Additional studies will be needed to determine the specific mechanisms responsible for the benefits see with aerobic and resistance training.

Hepatocellular carcinoma (HCC), a common malignancy in China and globally, is primarily treated through surgical resection and liver transplantation, with chemotherapy as a significant synergistic option. Adenine (Ade), a nucleobase, exhibits antitumor effects by blocking human hepatic carcinoma cells in S phase and inhibiting tumor cell proliferation. However, its use is limited owing to its low solubility, poor targeting ability, and nephrotoxicity. Therefore, liver-targeting drug delivery systems have attracted considerable attention for the treatment of HCC. In this study, we explored the liver-targeting efficacy and antitumor effect of adenine-loaded glycyrrhetinic acid-modified hyaluronic acid (Ade/GA-HA) nanoparticles in vitro and in vivo. The GA-HA nanoparticles possessed obvious targeting specificity toward liver cancer cells, which was mainly achieved by the specific binding of the GA ligand to the GA receptor that was highly expressed on the liver cell membrane. In vitro and in vivo results showed that Ade/GA-HA nanoparticles could inhibit liver cancer cell proliferation and migration, promote apoptosis, and significantly inhibit the growth of tumor tissues. Altogether, this study is the first to successfully demonstrate that the targeting activity and antitumor effect of Ade against HCC are enhanced by using GA-HA nanoparticles in vitro and in vivo.

Human centric lighting (HCL) is the development trend of future lighting. Human comfort is the result of the combined effects of complex factors, which not only include the illuminance factor of the lighting itself, but also need to consider the temperature, humidity, indoor air speed, and control factors of the environment. Based on the Cyber-Physical Human Centric System (CPHCS), this paper proposes a novel personal comfort model framework based on CPHCS. Analyze the correlation factors of the personal comfort lighting model through the correlation coefficient of the environmental data collected in the smart home, the human heart rate, and the human subjective comfort level data.

Developing environmentally friendly and sustainable nitrogen (N) fertilizer management strategies is crucial in mitigating carbon dioxide (CO2) emission from soil. How N fertilizer management practices influence soil CO2 emission rates under different crop rotations remains unclear. The aim of this study was to assess the impact on soil CO2 emission and soil physicochemical properties of three N fertilizer treatments including traditional rate (TF), optimized rate (0.8TF), and no fertilizer (NF) under three different crop rotation treatments: wheat-fallow (WF), wheat-soybean (WS), and wheat-maize (WM) over two years in a field experiment in northwest China. The rates were 5.51, 5.60, and 5.97 &mu, mol&middot, m&minus, 2&middot, s&minus, 1of mean soil CO2 emission under the TF, 0.8TF, and NF treatments, respectively. Mean soil CO2 emission rates were 21.33 and 26.99% higher under the WM rotation compared with the WF and WS rotations, respectively. The WS rotation showed higher soil nutrient content and lower soil CO2 emissions, and reduced fertilizer application. Importantly, soil organic carbon (SOC) concentration in the topsoil can be maximized by including either a summer legume or a summer maize crop in winter wheat rotations, and by applying N fertilizer at the optimal rate. This may be particularly beneficial in the dryland cropping systems of northern China.

Braiding is a common skill in daily life but rare at the nanoscale. Most of the current nanohelices are directly grown or assembled without involving mechanical interactions, and they are thus distinctively different from ropes in terms of functions and mechanisms. Here, by coaxially twisting multiple ultrathin Au nanowires, nanoropes are synthesized with elegant helical patterns that are consistent with the macroscopic equivalents. The strain relaxation of lattice transformation causes the nanowires to pursue the maximum degree of twisting, while the mutual packing interactions in a bundle prevent sideways emergence of U-turns. The consistent chirality of the seemingly independent strands can only arise when a first twisting strand causes morphological deformation in its neighbors, which induces the collective uni-directional twisting. The spontaneous braiding and the "remote" control of the nanowires involve mechanical interactions and possibly energy transmission, thus opening doors to chiral assembly and future smart nanodevices.

Duodenojejunal bypass (DJB) is an experimental procedure to study the mechanism of metabolic surgery in type 2 diabetes (T2DM),independent of weight changes. The aim of this study was to evaluate the role of Gastrointestinal (GI) glucose sensing and glucose transportation in DJB regulated glucose metabolism using T2DM rat model. T2DM was induced in Wistar rats with 2 months of high-fat diet and one low-dose streptozocin (STZ) injection. T2DM rats were randomly divided into sham operation group (T2DM-Sham, n=8) and DJB group (T2DM-DJB, n=8). Eight Wistar rats were used as wild type control group(Control, n=8). The results showed that DJB surgery significantly improved blood glucose homeostasis in T2DM rats. The hematoxylin-eosin staining results revealed that DJB operation thickened the wall of small intestine comparing to Sham operation. DJB also increased the length of villus in small intestine. Western Blot and qRT-PCR results showed that DJB significantly increased the expression of sodium-glucose co-transporter-1 (SGLT1) while reducing the expression of glucose transporter-2 (GLUT2) in the alimentary limb of DJB rats. The results also showed the expression of intestinal sweet receptors (T1R2/T1R3), Glucagon-like peptide 1/2 (GLP1/2) and its receptor (GLP1/2R) increased significantly in the alimentary limb after DJB surgery. Here we describe a new observation that DJB surgery lowers blood glucose level via intestinal glucose transport and glucose sensing regulation in the alimentary limb. Disclosure B. Jiang: None. H. Wang: None. W. Wang: None. Q. Yan: None. M. Qu: None. Z. Gao: None. Funding National Natural Science Foundation of China (81871892); Natural Science Foundation of Shandong Province (ZR2019BH036); Technology Development Plan of Weifang (2018YX027)

International audience; Microporous materials have attracted a rapid growth of research interest in materials science and the multidisciplinary area because of their wide applications in catalysis, separation, ion exchange, gas storage, drug release, and sensing. A fundamental understanding of their diverse structures and properties is crucial for rational design of high-performance materials and technological applications in industry. Solid-state NMR (SSNMR), capable of providing atomic-level information on both structure and dynamics, is a powerful tool in the scientific exploration of solid materials. Here, advanced SSNMR instruments and methods for characterization of microporous materials are briefly described. The recent progress of the application of SSNMR for the investigation of microporous materials including zeolites, metal-organic frameworks, covalent organic frameworks, porous aromatic frameworks, and layered materials is discussed with representative work. The versatile SSNMR techniques provide detailed information on the local structure, dynamics, and chemical processes in the confined space of porous materials. The challenges and prospects in SSNMR study of microporous and related materials are discussed.

Nitrogen fertilization significantly increases greenhouse gases (GHGs) emission, when applied from inorganic or organic sources. Minimizing GHGs from agroecosystems without compromising crop yield for stabilization of green production systems remains a challenge. Being an integral component of wheat production technology, the nitrogen (N) application deems to be indispensable. Thus, to reduce the application of N fertilizer and keep in view the minimization of GHGs emission, without compromising soil fertility and wheat production, field experiments were performed with treatments included maize straw mulch (S1: 0, S2: 4500, S3: 9000 kg ha

The harpin protein Hpa1 has various beneficial effects in plants, such as promoting plant growth and inducing pathogen resistance. Our previous study found that Hpa1 could significantly alleviate the mosaic symptoms of tobacco mosaic virus (TMV) in

A single-wavelength single-polarization 35GHz-class (112Gbps-class) commercial EML-based IM/DD 214Gbps PAM4 signal transmission is experimentally demonstrated. By using advanced MLSE with low complexity and power consumption, the BER is below standard KP4-FEC requirement of 2×10−4.

The voltage source converter based multi-terminal direct-current (VSC-MTDC) system is a promising technique to integrate multiple large offshore wind farms (OWF) and to share the power between multiple ac grids. The operation and control of VSC-MTDC systems could be affected by multiple uncertainties, e.g., the stochastic power generation of OWFs, nonlinearities of VSC-MTDC systems and unknown dynamics triggered by grid faults, which may result in poor dynamic performance and stability issues. In this paper, a perturbation observer-based nonlinear control (PONC) is proposed to improve the robustness of VSC-MTDC systems with OWFs. The perturbation observer is designed to estimate the lumped perturbation terms, which include all the system uncertainties, unknown dynamics and the external disturbances together with the state estimates. Based on the estimated perturbation and states, the output feedback linearization controllers are designed to compensate the impact of the lumped perturbation and to achieve robust tracking performance, without requiring the accurate system model. The effectiveness of PONC is verified by a 5-terminal VSC-MTDC system.

Addition of organic material, such as crop straw mulch in most soils is considered a strategy for sustainable agricultural production. We conducted a two-year experiment in 2015 and 2016 to determine changes in soil biochemical properties and maize yield in response to treatment with wheat-straw mulch. The treatments consisted of the addition of different levels of wheat-straw mulch (S1: 0, S2: 2500, S3: 5000 kg ha−1). Soil samples from four depths (0.1, 0.2, 0.3, and 0.4 m) were collected and analyzed. Soil enzymes, such as invertase, phosphatase, urease, and catalase, were significantly higher in the S3 treatment than in the S1 treatment. Values were greater for the samples collected at 0.1 m soil depth than those collected from deeper soil layers. Regarding soil properties, soil organic carbon (SOC), available nitrogen (AN), available phosphorus (AP), total nitrogen (TN), total phosphorus (TP), and soil water content (SWC) were significantly higher in S3 at 0–0.1 m soil depth than in other treatments. Compared with the (S1), an average increase in SOC, AN, AP, TN, TP, and SWC in 0–0.4 m soil depth with full straw mulch (S3), were 32.4, 31.9, 32.0, 11.8, 16.7, and 18.5%, higher, respectively. On average, urease, phosphatase, invertase, and catalase increased by 15.1, 11.0, 88.4, and 24.0%, respectively in the S3 treatment compared with that in the S1 treatment at 0–0.1 m depth, and decreased with increasing soil depth. The S3 treatment had increased grain yield (7%), biomass yield (28%), and water use efficiency (8%), compared with the S1 treatment. Overall, our results suggested that the S3 straw mulch treatment (5000 kg ha−1) could be used to sustain maize productivity and promote a better relationship between soil enzymes and soil properties in the semi-arid conditions of the Guanzhong area.

The morphologies of ABC miktoarm star terpolymer consisting of polystyrene (PS), polyisoprene (PI), and poly(2-vinylpyridine) (P2VP) were studied by combining small-angle neutron and X-ray scattering (SANS and SAXS) and transmission electron microscopy. We find that this system displays a rich morphological behavior including an alternate lamellar (ALT.LAM), cylinder in undulated lamellar (CYLULAM), and 3-lamellar (LAM-3) phase. While the SAXS data alone were insufficient to conclusively differentiate between possible phases, we show that the use of selective deuteration and SANS is essential to unambiguously identify the morphology. In particular, the primary peak in SANS for the miktoarm polymer containing deuterated PS was found to be lower than the next two higher order peaks. Such an unusual scattering pattern for a lamellar morphology was verified by self-consistent field theory calculations when the relative strength of the interaction between PI–P2VP over PS–PI is equal to or greater than 2 (χIV/χ...

Advanced glycation end products (AGEs) are complex and heterogeneous compounds, which play an important role in diabetic-related vascular complications, especially in atherosclerosis. In this study, the effects of ferulic acid (FA) on glucose-related protein glycation were investigated in vitro by various spectroscopic techniques and molecular docking methods. In order to study the protective effects of FA on AGEs-induced HUVEC cells damage, the mRNA expression of Caspase-1, NLRP3, CRP, ICAM-1, VCAM-1, IL-18 and IL-1β were detected. Moreover, NF-κB and p38 MAPK signaling pathways were analyzed. These results manifested that FA could effectively inhibit the AGEs formation, decrease the AGEs-induced mRNA expression of Caspase-1, NLRP3, CRP, ICAM-1, VCAM-1, IL-18 and IL-1β, and reduce intracellular ROS. FA could mitigate the AGEs-induced inflammatory response in HUVEC cells by suppressing the activation of NF-κB and p38 MAPK signaling pathways. These results suggested that FA might prevent and mitigate the development of atherosclerosis in diabetic patients.