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1,675 results on '"Washington, M."'

152. Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells With DNA Damage

Author

Chaturvedi, Rupesh, Asim, Mohammad, Piazuelo, M. Blanca, Yan, Fang, Barry, Daniel P., Sierra, Johanna Carolina, Delgado, Alberto G., Hill, Salisha, Casero, Robert A., Jr., Bravo, Luis E., Dominguez, Ricardo L., Correa, Pelayo, Polk, D. Brent, Washington, M. Kay, Rose, Kristie L., Schey, Kevin L., Morgan, Douglas R., Peek, Richard M., Jr., and Wilson, Keith T.

Published
2014
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157. Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer.

Author

Janczewski, Lauren M., Browner, Amanda E., Cotler, Joseph H., Nelson, Heidi, Kakar, Sanjay, Carr, Norman J., Hanna, Nader N., Holowatyj, Andreana N., Goldberg, Richard M., Washington, M. Kay, Asare, Elliot A., and Overman, Michael J.

Subjects
SURVIVAL rate, APPENDIX (Anatomy), TUMOR classification, BIG data, SURVIVAL analysis (Biometry)
Abstract

The standard for cancer staging in the United States for all cancer sites, including primary carcinomas of the appendix, is the American Joint Committee on Cancer (AJCC) staging system. AJCC staging criteria undergo periodic revisions, led by a panel of site‐specific experts, to maintain contemporary staging definitions through the evaluation of new evidence. Since its last revision, the AJCC has restructured its processes to include prospectively collected data because large data sets have become increasingly robust and available over time. Thus survival analyses using AJCC eighth edition staging criteria were used to inform stage group revisions in the version 9 AJCC staging system, including appendiceal cancer. Although the current AJCC staging definitions were maintained for appendiceal cancer, incorporating survival analysis into the version 9 staging system provided unique insight into the clinical challenges in staging rare malignancies. This article highlights the critical clinical components of the now published version 9 AJCC staging system for appendix cancer, which (1) justified the separation of three different histologies (non‐mucinous, mucinous, signet‐ring cell) in terms of prognostic variance, (2) demonstrated the clinical implications and challenges in staging heterogeneous and rare tumors, and (3) emphasized the influence of data limitations on survival analysis for low‐grade appendiceal mucinous neoplasms. [ABSTRACT FROM AUTHOR]

Published
2023
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158. Survival outcomes used to generate version 9 American Joint Committee on Cancer staging system for anal cancer.

Author

Janczewski, Lauren M., Faski, Joseph, Nelson, Heidi, Gollub, Marc J., Eng, Cathy, Brierley, James D., Palefsky, Joel M., Goldberg, Richard M., Washington, M. Kay, Asare, Elliot A., and Goodman, Karyn A.

Subjects
ANAL cancer, SURVIVAL rate, TUMOR classification, BIG data, SURVIVAL analysis (Biometry)
Abstract

The American Joint Committee on Cancer (AJCC) staging system for all cancer sites, including anal cancer, is the standard for cancer staging in the United States. The AJCC staging criteria are dynamic, and periodic updates are conducted to optimize AJCC staging definitions through a panel of experts charged with evaluating new evidence to implement changes. With greater availability of large data sets, the AJCC has since restructured and updated its processes, incorporating prospectively collected data to validate stage group revisions in the version 9 AJCC staging system, including anal cancer. Survival analysis using AJCC eighth edition staging guidelines revealed a lack of hierarchical order in which stage IIIA anal cancer was associated with a better prognosis than stage IIB disease, suggesting that, for anal cancer, tumor (T) category has a greater effect on survival than lymph node (N) category. Accordingly, version 9 stage groups have been appropriately adjusted to reflect contemporary long‐term outcomes. This article highlights the changes to the now published AJCC staging system for anal cancer, which: (1) redefined stage IIB as T1–T2N1M0 disease, (2) redefined stage IIIA as T3N0–N1M0 disease, and (3) eliminated stage 0 disease from its guidelines altogether. [ABSTRACT FROM AUTHOR]

Published
2023
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159. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection

Author

Zackular, Joseph P, Moore, Jessica L, Jordan, Ashley T, Juttukonda, Lillian J, Noto, Michael J, Nicholson, Maribeth R, Crews, Jonathan D, Semler, Matthew W, Zhang, Yaofang, Ware, Lorraine B, Washington, M Kay, Chazin, Walter J, Caprioli, Richard M, and Skaar, Eric P

Subjects
Development and progression, Risk factors, Health aspects, Zinc (Nutrient) -- Health aspects, Microbiota (Symbiotic organisms) -- Health aspects, Clostridium infections -- Risk factors -- Development and progression
Abstract

Author(s): Joseph P Zackular [1]; Jessica L Moore [2, 3]; Ashley T Jordan [1]; Lillian J Juttukonda [1]; Michael J Noto [1, 4]; Maribeth R Nicholson [5]; Jonathan D Crews [...]

Published
2016
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161. EGFR regulates macrophage activation and function in bacterial infection

Author

Hardbower, Dana M., Singh, Kshipra, Asim, Mohammad, Verriere, Thomas G., Olivares-Villagomez, Danyvid, Barry, Daniel P., Allaman, Margaret M., Washington, M. Kay, Peek, Jr., Richard M., Piazuelo, M. Blanca, and Wilson, Keith T.

Subjects
Care and treatment, Complications and side effects, Research, Risk factors, Bacterial infections -- Research -- Care and treatment -- Complications and side effects, Stomach cancer -- Health aspects -- Research -- Care and treatment -- Complications and side effects, Macrophages -- Health aspects -- Research, Inflammation -- Health aspects -- Research -- Risk factors
Abstract

Introduction Macrophages represent a dynamic subset of innate immune cells, with functions in immune surveillance, immunity to pathogens, wound healing, antigen presentation, and cytokine and chemokine production (1-3). A critical [...], EGFR signaling regulates macrophage function, but its role in bacterial infection has not been investigated. Here, we assessed the role of macrophage EGFR signaling during infection with Helicobacter pylori, a bacterial pathogen that causes persistent inflammation and gastric cancer. EGFR was phosphorylated in murine and human macrophages during H. pylori infection. In human gastric tissues, elevated levels of phosphorylated EGFR were observed throughout the histologic cascade from gastritis to carcinoma. Deleting EGFR in myeloid cells attenuated gastritis and increased H. pylori burden in infected mice. EGFR deficiency also led to a global defect in macrophage activation that was associated with decreased cytokine, chemokine, and NO production. We observed similar alterations in macrophage activation and disease phenotype in the Citrobacter rodentium model of murine infectious colitis. Mechanistically, EGFR signaling activated NF-κB and MAPK1/3 pathways to induce cytokine production and macrophage activation. Although deletion of Egfr had no effect on DC function, EGFR- deficient macrophages displayed impaired Th1 and Th17 adaptive immune responses to H. pylori, which contributed to decreased chronic inflammation in infected mice. Together, these results indicate that EGFR signaling is central to macrophage function in response to enteric bacterial pathogens and is a potential therapeutic target for infection-induced inflammation and associated carcinogenesis.

Published
2016
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172. EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Author

Ardito, Christine M., Grüner, Barbara M., Takeuchi, Kenneth K., Lubeseder-Martellato, Clara, Teichmann, Nicole, Mazur, Pawel K., DelGiorno, Kathleen E., Carpenter, Eileen S., Halbrook, Christopher J., Hall, Jason C., Pal, Debjani, Briel, Thomas, Herner, Alexander, Trajkovic-Arsic, Marija, Sipos, Bence, Liou, Geou-Yarh, Storz, Peter, Murray, Nicole R., Threadgill, David W., Sibilia, Maria, Washington, M. Kay, Wilson, Carole L., Schmid, Roland M., Raines, Elaine W., Crawford, Howard C., and Siveke, Jens T.

Published
2012
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178. Cancer-Associated Fibroblasts and Squamous Epithelial Cells Constitute a Unique Microenvironment in a Mouse Model of Inflammation-Induced Colon Cancer

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Vega, Paige N, Nilsson, Avlant, Kumar, Manu P, Niitsu, Hiroaki, Simmons, Alan J, Ro, James, Wang, Jiawei, Chen, Zhengyi, Joughin, Brian A, Li, Wei, McKinley, Eliot T, Liu, Qi, Roland, Joseph T, Washington, M Kay, Coffey, Robert J, Lauffenburger, Douglas A, Lau, Ken S, Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Vega, Paige N, Nilsson, Avlant, Kumar, Manu P, Niitsu, Hiroaki, Simmons, Alan J, Ro, James, Wang, Jiawei, Chen, Zhengyi, Joughin, Brian A, Li, Wei, McKinley, Eliot T, Liu, Qi, Roland, Joseph T, Washington, M Kay, Coffey, Robert J, Lauffenburger, Douglas A, and Lau, Ken S

Abstract

The tumor microenvironment plays a key role in the pathogenesis of colorectal tumors and contains various cell types including epithelial, immune, and mesenchymal cells. Characterization of the interactions between these cell types is necessary for revealing the complex nature of tumors. In this study, we used single-cell RNA-seq (scRNA-seq) to compare the tumor microenvironments between a mouse model of sporadic colorectal adenoma (Lrig1CreERT2/+;Apc2lox14/+) and a mouse model of inflammation-driven colorectal cancer induced by azoxymethane and dextran sodium sulfate (AOM/DSS). While both models develop tumors in the distal colon, we found that the two tumor types have distinct microenvironments. AOM/DSS tumors have an increased abundance of two populations of cancer-associated fibroblasts (CAFs) compared with APC tumors, and we revealed their divergent spatial association with tumor cells using multiplex immunofluorescence (MxIF) imaging. We also identified a unique squamous cell population in AOM/DSS tumors, whose origins were distinct from anal squamous epithelial cells. These cells were in higher proportions upon administration of a chemotherapy regimen of 5-Fluorouracil/Irinotecan. We used computational inference algorithms to predict cell-cell communication mediated by ligand-receptor interactions and downstream pathway activation, and identified potential mechanistic connections between CAFs and tumor cells, as well as CAFs and squamous epithelial cells. This study provides important preclinical insight into the microenvironment of two distinct models of colorectal tumors and reveals unique roles for CAFs and squamous epithelial cells in the AOM/DSS model of inflammation-driven cancer.

Published
2022

182. SMAD4 suppresses colitis-associated carcinoma through inhibition of CCL20/CCR6-mediated inflammation

Author

Hanna, David N., primary, Smith, Paula Marincola, additional, Novitskiy, Sergey V., additional, Washington, M. Kay, additional, Zi, Jinghuan, additional, Weaver, Connie J., additional, Hamaamen, Jalal A., additional, Lewis, Keeli B., additional, Zhu, Jing, additional, Yang, Jing, additional, Liu, Qi, additional, Beauchamp, R. Daniel, additional, and Means, Anna L., additional

Published
2022
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185. Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis

Author

Noto, Jennifer M., primary, Piazuelo, M. Blanca, additional, Shah, Shailja C., additional, Romero-Gallo, Judith, additional, Hart, Jessica L., additional, Di, Chao, additional, Carmichael, James D., additional, Delgado, Alberto G., additional, Halvorson, Alese E., additional, Greevy, Robert A., additional, Wroblewski, Lydia E., additional, Sharma, Ayushi, additional, Newton, Annabelle B., additional, Allaman, Margaret M., additional, Wilson, Keith T., additional, Washington, M. Kay, additional, Calcutt, M. Wade, additional, Schey, Kevin L., additional, Cummings, Bethany P., additional, Flynn, Charles R., additional, Zackular, Joseph P., additional, and Peek, Richard M., additional

Published
2022
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186. Cancer-Associated Fibroblasts and Squamous Epithelial Cells Constitute a Unique Microenvironment in a Mouse Model of Inflammation-Induced Colon Cancer

Author

Vega, Paige N., primary, Nilsson, Avlant, additional, Kumar, Manu P., additional, Niitsu, Hiroaki, additional, Simmons, Alan J., additional, Ro, James, additional, Wang, Jiawei, additional, Chen, Zhengyi, additional, Joughin, Brian A., additional, Li, Wei, additional, McKinley, Eliot T., additional, Liu, Qi, additional, Roland, Joseph T., additional, Washington, M. Kay, additional, Coffey, Robert J., additional, Lauffenburger, Douglas A., additional, and Lau, Ken S., additional

Published
2022
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187. Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Author

Gobert, Alain P., primary, Latour, Yvonne L., additional, Asim, Mohammad, additional, Barry, Daniel P., additional, Allaman, Margaret M., additional, Finley, Jordan L., additional, Smith, Thaddeus M., additional, McNamara, Kara M., additional, Singh, Kshipra, additional, Sierra, Johanna C., additional, Delgado, Alberto G., additional, Luis, Paula B., additional, Schneider, Claus, additional, Washington, M. Kay, additional, Piazuelo, M. Blanca, additional, Zhao, Shilin, additional, Coburn, Lori A., additional, and Wilson, Keith T., additional

Published
2022
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195. Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

Author

Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, and Hiebert, Scott W.

Published
2010
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