151. Interactions Between 5-Fluorouracil and PAMAM Dendrimers Studies by NMR Spectroscopy
- Author
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NING Cai-fang, MA Min-jun, GUO Zhao-hui, ZHANG Shu-huai, QIAO Yan, and WANG Ying-xiong
- Subjects
liquid-state nmr ,interaction ,pamam dendrimers ,5-fluorouracil ,Electricity and magnetism ,QC501-766 - Abstract
Interactions between 5-fluorouracil (5-FU) and PAMAM in D2O solution were studied by NMR spectroscopy. The results of 1H NMR chemical shift titration experiments demonstrated that 5-FU molecules bonded to the surface of PAMAM, and the results of 13C NMR chemical shift titrations experiments disclosed that hydrogen-bond interactions and/or hydrophobic interaction ins existed in the interior pockets of PAMAM and 5-FU. These results were further supported by 1H and 19F relaxation time measurements. The NOESY experiment was used to confirm the presence of 5-FU encapsulation in the PAMAM-5-FU complexes. This study provides a methodology for studying the interactions between dendrimers and drug molecules.
- Published
- 2019
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