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151. Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial

Author

Bird, J. Andrew, Spergel, Jonathan M., Jones, Stacie M., Rachid, Rima, Assa'ad, Amal H., Wang, Julie, Leonard, Stephanie A., Laubach, Susan S., Kim, Edwin H., Vickery, Brian P., Davis, Benjamin P., Heimall, Jennifer, Cianferoni, Antonella, MacGinnitie, Andrew J., Crestani, Elena, and Burks, A. Wesley

Published
2018
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163. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy

Author

Greenhawt, Matthew, primary, Sindher, Sayantani B., additional, Wang, Julie, additional, O’Sullivan, Michael, additional, du Toit, George, additional, Kim, Edwin H., additional, Albright, Deborah, additional, Anvari, Sara, additional, Arends, Nicolette, additional, Arkwright, Peter D., additional, Bégin, Philippe, additional, Blumchen, Katharina, additional, Bourrier, Thierry, additional, Brown-Whitehorn, Terri, additional, Cassell, Heather, additional, Chan, Edmond S., additional, Ciaccio, Christina E., additional, Deschildre, Antoine, additional, Divaret-Chauveau, Amandine, additional, Dorris, Stacy L., additional, Dorsey, Morna J., additional, Eiwegger, Thomas, additional, Erlewyn-Lajeunesse, Michel, additional, Fleischer, David M., additional, Ford, Lara S., additional, Garcia-Lloret, Maria, additional, Giovannini-Chami, Lisa, additional, Hourihane, Jonathan O., additional, Jay, Nicola, additional, Jones, Stacie M., additional, Kerns, Leigh Ann, additional, Kloepfer, Kirsten M., additional, Leonard, Stephanie, additional, Lezmi, Guillaume, additional, Lieberman, Jay A., additional, Lomas, Jeanne, additional, Makhija, Melanie, additional, Parrish, Christopher, additional, Peake, Jane, additional, Perrett, Kirsten P., additional, Petroni, Daniel, additional, Pfützner, Wolfgang, additional, Pongracic, Jacqueline A., additional, Quinn, Patrick, additional, Robison, Rachel G., additional, Sanders, Georgiana, additional, Schneider, Lynda, additional, Sharma, Hemant P., additional, Trujillo, Juan, additional, Turner, Paul J., additional, Tuttle, Katherine, additional, Upton, Julia E., additional, Varshney, Pooja, additional, Vickery, Brian P., additional, Vogelberg, Christian, additional, Wainstein, Brynn, additional, Wood, Robert A., additional, Bee, Katharine J., additional, Campbell, Dianne E., additional, Green, Todd D., additional, Rouissi, Rihab, additional, Peillon, Aurélie, additional, Bahnson, Henry T., additional, Bois, Timothée, additional, Sampson, Hugh A., additional, and Burks, A. Wesley, additional

Published
2023
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164. Quitting cigarettes completely or switching to smokeless tobacco: do US data replicate the Swedish results?

Author

Zhu, Shu-Hong, Wang, Julie B, Hartman, Anne, Zhuang, Yuerong, Gamst, Anthony, Gibson, James T, Gilljam, Hans, and Galanti, Maria Rosaria

Subjects
smoking cessation, smokeless tobacco
Abstract

BACKGROUND: Swedish male smokers are more likely than female smokers to switch to smokeless tobacco(snus) and males' smoking cessation rate is higher than that of females. These results have fuelled international debate over promoting smokeless tobacco for harm reduction. This study examines whether similar results emerge in the United States, one of few other western countries where smokeless tobacco has long been widely available.METHODS:US DATA SOURCE: national sample in Tobacco Use Supplement to Current Population Survey, 2002, with 1-year follow-up in 2003. Analyses included adult self-respondents in this longitudinal sample (n = 15,056). Population-weighted rates of quitting smoking and switching to smokeless tobacco were computed for the 1-year period.RESULTS:Among US men, few current smokers switched to smokeless tobacco (0.3% in 12 months). Few formersmokers turned to smokeless tobacco (1.7%). Switching between cigarettes and smokeless tobacco, infrequent among current tobacco users (

Published
2009

170. A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma [Corrigendum]

Author

Ko,Fanny Wai-San, Wang,Julie KL, Hui,David SC, Chan,Johnny WM, Cheung,Pik-Shan, Yeung,Yiu-Cheong, Sin,Kit Man, Ip,Mary Sau-Man, Ko,Fanny Wai-San, Wang,Julie KL, Hui,David SC, Chan,Johnny WM, Cheung,Pik-Shan, Yeung,Yiu-Cheong, Sin,Kit Man, and Ip,Mary Sau-Man

Abstract

Ko FWS, Wang JKL, Hui DSC, et al. J Asthma Allergy. 2023;16:173-182. The authors have advised there is an error in Table 1. Table 1 on Page 177, in the third-to-last row, data addressing Median (IQR) for Eosinophil count, cells/mm3 should read from 3.2 (1.7, 6.0) to 240.0 (110.0, 410.0). The authors apologize for this error. Correct Table 1

Published
2023

171. A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma

Author

Ko,Fanny Wai-San, Wang,Julie KL, Hui,David SC, Chan,Johnny WM, Cheung,Pik-Shan, Yeung,Yiu-Cheong, Sin,Kit Man, Ip,Mary Sau-Man, Ko,Fanny Wai-San, Wang,Julie KL, Hui,David SC, Chan,Johnny WM, Cheung,Pik-Shan, Yeung,Yiu-Cheong, Sin,Kit Man, and Ip,Mary Sau-Man

Abstract

Fanny Wai-San Ko,1 Julie KL Wang,2 David SC Hui,1 Johnny WM Chan,3 Pik-Shan Cheung,4 Yiu-Cheong Yeung,5 Kit Man Sin,6 Mary Sau-Man Ip7 1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 2Department of Medicine, Queen Mary Hospital, Hong Kong, People’s Republic of China; 3Department of Medicine, Queen Elizabeth Hospital, Hong Kong, People’s Republic of China; 4Department of Medicine, United Christian Hospital, Hong Kong, People’s Republic of China; 5Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, People’s Republic of China; 6Department of Medicine, Tuen Mun Hospital, Hong Kong, People’s Republic of China; 7Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaCorrespondence: Mary Sau-Man Ip, Division of Respiratory Medicine, Department of Medicine, School of Clinical Medicine, The University of Hong Kong, 4/F, Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong, People’s Republic of China, Email msmip@hkucc.hku.hkBackground: Patients with severe asthma have higher total- and asthma-related health burden than those whose disease is not severe. Recent medical advances in biologic therapies allow better control of asthma characterized by type 2 inflammation.Objective: To study the prevalence of eosinophilic phenotype and IgE levels in Chinese with severe asthma, and the relationship of these type 2 characteristics with asthma control, exacerbations and lung function.Methods: This was a multicenter cross-sectional observational study in Hong Kong, in Chinese adults with asthma on Step 4 or 5 of GINA treatment. Their blood eosinophil counts and total IgE levels were measured, and the relationship of these phenotypic parameters to the number of exacerbations in the past 12 months, and to symptom control in the past 4 weeks, were investigated.Results: A total of 232 subjects were recruited

Published
2023

172. Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evaluation and management:A GRADE assessment and international consensus approach

Author

Greenhawt, Matthew, Dribin, Timothy E., Abrams, Elissa M., Shaker, Marcus, Chu, Derek K., Golden, David B.K., Akin, Cem, Anagnostou, Akterini, ALMuhizi, Faisal, Alqurashi, Waleed, Arkwright, Peter, Baldwin, James L., Banerji, Aleena, Bégin, Philippe, Ben-Shoshan, Moshe, Bernstein, Jonathan, Bingemann, Theresa A., Bindslev-Jensen, Carsten, Blumenthal, Kim, Byrne, Aideen, Cahill, Julia, Cameron, Scott, Campbell, Dianne, Campbell, Ronna, Cavender, Michael, Chan, Edmond S., Chinthrajah, Sharon, Comberiati, Pasquale, Eastman, Jacqueline J., Ellis, Anne K., Fleischer, David M., Fox, Adam, Frischmeyer-Guerrerio, Pamela A., Gagnon, Remi, Garvey, Lene H., Grayson, Mitchell H., Isabwe, Ghislaine Annie Clarisse, Hartog, Nicholas, Hendron, David, Horner, Caroline C., Hourihane, Johnathan O.B., Iglesia, Edward, Kan, Manstein, Kaplan, Blanka, Katelaris, Constance H., Kim, Harold, Kelso, John M., Khan, David A., Lang, David, Ledford, Dennis, Levin, Michael, Lieberman, Jay A., Loh, Richard, Mack, Douglas P., Mazer, Bruce, Mody, Ketan, Mosnaim, Gisele, Munblit, Daniel, Mustafa, S. Shahzad, Nanda, Anil, Nathan, Richard, Oppenheimer, John, Otani, Iris M., Park, Miguel, Pawankar, Ruby, Perrett, Kirsten P., Peter, Jonny, Phillips, Elizabeth J., Picard, Matthieu, Pitlick, Mitchell, Ramsey, Allison, Rasmussen, Trine Holm, Rathkopf, Melinda M., Reddy, Hari, Robertson, Kara, Rodriguez del Rio, Pablo, Sample, Stephen, Sheshadri, Ajay, Sheik, Javed, Sindher, Sayantani B., Spergel, Jonathan M., Stone, Cosby A., Stukus, David, Tang, Mimi L.K., Tracy, James M., Turner, Paul J., Vander Leek, Timothy K., Wallace, Dana V., Wang, Julie, Wasserman, Susan, Weldon, David, Wolfson, Anna R., Worm, Margitta, Yacoub, Mona Rita, Greenhawt, Matthew, Dribin, Timothy E., Abrams, Elissa M., Shaker, Marcus, Chu, Derek K., Golden, David B.K., Akin, Cem, Anagnostou, Akterini, ALMuhizi, Faisal, Alqurashi, Waleed, Arkwright, Peter, Baldwin, James L., Banerji, Aleena, Bégin, Philippe, Ben-Shoshan, Moshe, Bernstein, Jonathan, Bingemann, Theresa A., Bindslev-Jensen, Carsten, Blumenthal, Kim, Byrne, Aideen, Cahill, Julia, Cameron, Scott, Campbell, Dianne, Campbell, Ronna, Cavender, Michael, Chan, Edmond S., Chinthrajah, Sharon, Comberiati, Pasquale, Eastman, Jacqueline J., Ellis, Anne K., Fleischer, David M., Fox, Adam, Frischmeyer-Guerrerio, Pamela A., Gagnon, Remi, Garvey, Lene H., Grayson, Mitchell H., Isabwe, Ghislaine Annie Clarisse, Hartog, Nicholas, Hendron, David, Horner, Caroline C., Hourihane, Johnathan O.B., Iglesia, Edward, Kan, Manstein, Kaplan, Blanka, Katelaris, Constance H., Kim, Harold, Kelso, John M., Khan, David A., Lang, David, Ledford, Dennis, Levin, Michael, Lieberman, Jay A., Loh, Richard, Mack, Douglas P., Mazer, Bruce, Mody, Ketan, Mosnaim, Gisele, Munblit, Daniel, Mustafa, S. Shahzad, Nanda, Anil, Nathan, Richard, Oppenheimer, John, Otani, Iris M., Park, Miguel, Pawankar, Ruby, Perrett, Kirsten P., Peter, Jonny, Phillips, Elizabeth J., Picard, Matthieu, Pitlick, Mitchell, Ramsey, Allison, Rasmussen, Trine Holm, Rathkopf, Melinda M., Reddy, Hari, Robertson, Kara, Rodriguez del Rio, Pablo, Sample, Stephen, Sheshadri, Ajay, Sheik, Javed, Sindher, Sayantani B., Spergel, Jonathan M., Stone, Cosby A., Stukus, David, Tang, Mimi L.K., Tracy, James M., Turner, Paul J., Vander Leek, Timothy K., Wallace, Dana V., Wang, Julie, Wasserman, Susan, Weldon, David, Wolfson, Anna R., Worm, Margitta, and Yacoub, Mona Rita

Abstract

This guidance updates 2021 GRADE (Grading of Recommendations Assessment, Development and Evaluation) recommendations regarding immediate allergic reactions following coronavirus disease 2019 (COVID-19) vaccines and addresses revaccinating individuals with first-dose allergic reactions and allergy testing to determine revaccination outcomes. Recent meta-analyses assessed the incidence of severe allergic reactions to initial COVID-19 vaccination, risk of mRNA-COVID-19 revaccination after an initial reaction, and diagnostic accuracy of COVID-19 vaccine and vaccine excipient testing in predicting reactions. GRADE methods informed rating the certainty of evidence and strength of recommendations. A modified Delphi panel consisting of experts in allergy, anaphylaxis, vaccinology, infectious diseases, emergency medicine, and primary care from Australia, Canada, Europe, Japan, South Africa, the United Kingdom, and the United States formed the recommendations. We recommend vaccination for persons without COVID-19 vaccine excipient allergy and revaccination after a prior immediate allergic reaction. We suggest against >15-minute postvaccination observation. We recommend against mRNA vaccine or excipient skin testing to predict outcomes. We suggest revaccination of persons with an immediate allergic reaction to the mRNA vaccine or excipients be performed by a person with vaccine allergy expertise in a properly equipped setting. We suggest against premedication, split-dosing, or special precautions because of a comorbid allergic history.

Published
2023

183. Vascular safety of erenumab for migraine prevention

Author

Kudrow, David, Pascual, Julio, Winner, Paul K., Dodick, David W., Tepper, Stewart J., Reuter, Uwe, Hong, Frank, Klatt, Jan, Zhang, Feng, Cheng, Sunfa, Picard, Hernan, Eisele, Osa, Wang, Julie, Latham, Jonathan N., and Mikol, Daniel D.

Published
2020
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184. Updated guidance regarding the risk ofAllergic reactions to COVID-19 vaccines and recommended evaluation and management: a GRADE assessment, and international consensus approach

Author

Greenhawt, Matthew, Dribin, Timothy E., Abrams, Elissa M., Shaker, Marcus, Chu, Derek K., Golden, David Bk., Akin, Cem, Anagnostou, Akterini, Almuhizi, Faisal, Alqurashi, Waleed, Arkwright, Peter, Baldwin, James L., Banerji, Aleena, Bégin, Philippe, Ben-Shoshan, Moshe, Bernstein, Jonathan, Bingeman, Theresa A., Bindslev-Jensen, Carsten, Blumenthal, Kim, Byrne, Aideen, Cahil, Julia, Cameron, Scott, Campbell, Dianne, Campbell, Ronna, Cavender, Michael, Chan, Edmond S., Chinthrajah, Sharon, Comberiatti, Pasquale, Eastman, Jacqueline J., Ellis, Anne K., Fleischer, David M., Fox, Adam, Frischmeyer-Guerrerio, Pamela A., Gagnon, Remi, Garvey, Lene H., Grayson, Mitchell H., Clarisse isabwe, Ghislaine Annie, Hartog, Nicholas, Hendron, David, Horner, Caroline C., O'b hourihane, Johnathan, Iglesia, Edward, Kan, Manstein, Kaplan, Blanca, Katelaris, Constance H., Kim, Harold, Kelso, John M., Kahn, David A., Lang, David, Ledford, Dennis, Levin, Michael, Lieberman, Jay A., Loh, Richard, Mack, Douglas P., Mazer, Bruce, Mody, Ketan, Mosnaim, Gissele, Munblit, Daniel, Mustafa, S. Shahzad, Nanda, Anil, Nathan, Richard, Oppenheimer, John, Otani, Iris M., Park, Miguel, Pawankar, Ruby, Perrett, Kirsten P., Peter, Jonny, Phillips, Elizabeth J., Picard, Matthieu, Pitlick, Mitchell, Ramsey, Allison, Rasmussen, Trine Holm, Rathkopf, Melinda M., Reddy, Hari, Robertson, Kara, Rodriguez del rio, Pablo, Sample, Steven, Sheshradi, Ajay, Shiek, Javed, Sindher, Sayantani B., Spergel, Jonathan M., Stone, Cosby A., Stukus, David, Tang, Mimi Lk., Tracy, James M., Turner, Paul J., Vander leek, Timothy K., Wallace, Dana V., Wang, Julie, Wasserman, Susan, Weldon, David, Wolfson, Anna R., Worm, Margitta, and Yacoub, Mona-rita

Subjects
SARS-CoV-2, shared decision-making, COVID-19, allergy specialist, allergic reactions, vaccination, skin testing, allergy, mRNA COVID-19 vaccine, GRADE, polyethylene glycol, anaphylaxis, repeat allergic reactions, polysorbate 80, adenovirus vector vaccine
Abstract

This guidance updates 2021 GRADE recomendations regarding immediate allergic reactions following COVID-19 vaccines and addresses re-vaccinating individuals with 1 st dose allergic reactions and allergy testing to determine re-vaccination outcomes. Recent meta-analyses assessed the incidence of severe allergic reactions to initial COVID-19 vaccination, risk of mRNA-COVID-19 re-vaccination after an initial reaction, and diagnostic accuracy of COVID-19 vaccine and vaccine excipient testing in predicting reactions. GRADE methods informed rating the certainty of evidence and strength of recommenations. A modified Delphi panel consisting of experts in allergy, anaphylaxis, vaccinology, infectious diseases, emergency medicine, and primary care from Australia, Canada, Europe, Japan, South Africa, the UK, and the US formed the recommendations. We recommend vaccination for persons without COVID-19 vaccine excipient allergy, and re-vaccination after a prior immediate allergic reaction. We suggest against >15-minute post-vaccination observation. We recommend against mRNA vaccine or excipient skin testing to predict outcomes. We suggest re-vaccination of persons with an immediate allergic reaction to the mRNA vaccine or excipients be performed by a person with vaccine allergy expertise, in a properly equipped setting. We suggest against pre-medication, split-dosing, or special precautions because of a comorbid allergic history.

Published
2023

193. The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders

Author

Sindher, Sayantani B., primary, Barshow, Suzanne, additional, Tirumalasetty, Jyothi, additional, Arasi, Stefania, additional, Atkins, Dan, additional, Bauer, Maureen, additional, Bégin, Philippe, additional, Collins, Margaret H., additional, Deschildre, Antoine, additional, Doyle, Alfred D., additional, Fiocchi, Alessandro, additional, Furuta, Glenn T., additional, Garcia-Lloret, Maria, additional, Mennini, Maurizio, additional, Rothenberg, Marc E., additional, Spergel, Jonathan M., additional, Wang, Julie, additional, Wood, Robert A., additional, Wright, Benjamin L., additional, Zuberbier, Torsten, additional, Chin, Andrew R., additional, Long, Andrew, additional, Nadeau, Kari C., additional, and Chinthrajah, R. Sharon, additional

Published
2023
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195. Inhibition of pathologic immunoglobulin E in food allergy by EBF-2 and active compound berberine associated with immunometabolism regulation

Author

Yang, Nan, primary, Maskey, Anish R., additional, Srivastava, Kamal, additional, Kim, Monica, additional, Wang, Zixi, additional, Musa, Ibrahim, additional, Shi, Yanmei, additional, Gong, Yixuan, additional, Fidan, Ozkan, additional, Wang, Julie, additional, Dunkin, David, additional, Chung, Danna, additional, Zhan, Jixun, additional, Miao, Mingsan, additional, Sampson, Hugh A., additional, and Li, Xiu-Min, additional

Published
2023
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196. Inhibition of Pathologic Immunoglobulin E In Food Allergy by EBF2 and Active Compound Berberine Associated with Immunometabolism Regulation

Author

Maskey, Anish, primary, Yang, Nan, additional, Kim, Monica, additional, Srivastava, Kamal, additional, Wang, Zixi, additional, Shi, Yanmei, additional, Gong, Yixuan, additional, Wang, Julie, additional, Dunkin, David, additional, Chung, Danna, additional, Zhan, Jixun, additional, Miao, Mingsan, additional, Sampson, Hugh, additional, and Li, Xiu-Min, additional

Published
2023
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199. Values and Preferences of Patients and Caregivers Regarding Treatment of Atopic Dermatitis (Eczema)

Author

Maleki-Yazdi, Keon Andre, primary, Heen, Anja Fog, additional, Zhao, Irene X., additional, Guyatt, Gordon H., additional, Suzumura, Erica A., additional, Makhdami, Nima, additional, Chen, Lina, additional, Winders, Tonya, additional, Wheeler, Kathryn E., additional, Wang, Julie, additional, Spergel, Jonathan, additional, Silverberg, Jonathan I., additional, Ong, Peck Y., additional, O’Brien, Monica, additional, Martin, Stephen A., additional, Lio, Peter A., additional, Lind, Mary Laura, additional, LeBovidge, Jennifer, additional, Kim, Elaine, additional, Huynh, Joey, additional, Greenhawt, Matthew, additional, Frazier, Winfred T., additional, Ellison, Kathy, additional, Capozza, Korey, additional, De Benedetto, Anna, additional, Boguniewicz, Mark, additional, Begolka, Wendy Smith, additional, Asiniwasis, Rachel Netahe, additional, Schneider, Lynda C., additional, and Chu, Derek K., additional

Published
2023
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200. 321 Cancer risk with topical pimecrolimus and tacrolimus for atopic dermatitis: systematic review and Bayesian meta-analysis

Author

Chu, Alexandro W L, primary, Devasenapathy, Niveditha, additional, Wong, Melanie, additional, Srivastava, Archita, additional, Ceccacci, Renata, additional, Lin, Clement, additional, MacDonald, Margaret, additional, Wen, Aaron, additional, Steen, Jeremy, additional, Levine, Mitchell, additional, Pyne, Lonnie, additional, Wang, Julie, additional, Spergel, Jonathan M, additional, Silverberg, Jonathan I, additional, Ong, Peck Y, additional, O’Brien, Monica, additional, Martin, Stephan A, additional, Lio, Peter A, additional, Lind, Mary Laura, additional, LeBovidge, Jennifer, additional, Kim, Elaine, additional, Huynh, Joey, additional, Greenhawt, Matthew, additional, Frazier, Winfred T, additional, Chen, Lina, additional, De Benedetto, Anna, additional, Boguniewicz, Mark, additional, Asiniwasis, Rachel N, additional, Schneider, Lynda, additional, and Chu, Derek K, additional

Published
2023
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