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Electrocatalytic NO2− reduction to NH3 (NO2RR) is an appealing approach for mitigating NO2− pollution and for the synthesis of valuable NH3, and so the exploration for high-performance NO2RR catalysts is pivotal yet remains challenging. Herein, amorphous MoO3 nanosheets (am-MoO3) were designed as a high-performance NO2RR electrocatalyst, delivering a maximum NO2−-to-NH3 faradaic efficiency of 94.8% and NH3 yield rate of 480.4 μmol h−1 cm−2 at −0.6 V vs. RHE. Theoretical computations revealed that the largely enhanced NO2RR activity of am-MoO3 originated from the amorphization-induced O-vacancies, which could enhance the NO2−-to-NH3 reaction energetics and hamper the competitive hydrogen evolution. [ABSTRACT FROM AUTHOR]

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies have proven that every stage in the human reproductive process is regulated by multiple genes and any problem, at any step, may lead to fertilization failure (FF) or early embryonic arrest (EEA). Doctors can diagnose the pathogenic factors involved in FF and EEA by using genetic methods. With the progress in the development of new genetic technologies, such as single-cell RNA analysis and whole-exome sequencing, a new approach has opened up for us to directly study human germ cells and reproductive development. These findings will help us to identify the unique mechanism(s) that leads to FF and EEA in order to find potential treatments. OBJECTIVE AND RATIONALE The goal of this review is to compile current genetic knowledge related to FF and EEA, clarifying the mechanisms involved and providing clues for clinical diagnosis and treatment. SEARCH METHODS PubMed was used to search for relevant research articles and reviews, primarily focusing on English-language publications from January 1978 to June 2023. The search terms included fertilization failure, early embryonic arrest, genetic, epigenetic, whole-exome sequencing, DNA methylation, chromosome, non-coding RNA, and other related keywords. Additional studies were identified by searching reference lists. This review primarily focuses on research conducted in humans. However, it also incorporates relevant data from animal models when applicable. The results were presented descriptively, and individual study quality was not assessed. OUTCOMES A total of 233 relevant articles were included in the final review, from 3925 records identified initially. The review provides an overview of genetic factors and mechanisms involved in the human reproductive process. The genetic mutations and other genetic mechanisms of FF and EEA were systematically reviewed, for example, globozoospermia, oocyte activation failure, maternal effect gene mutations, zygotic genome activation abnormalities, chromosome abnormalities, and epigenetic abnormalities. Additionally, the review summarizes progress in treatments for different gene defects, offering new insights for clinical diagnosis and treatment. WIDER IMPLICATIONS The information provided in this review will facilitate the development of more accurate molecular screening tools for diagnosing infertility using genetic markers and networks in human reproductive development. The findings will also help guide clinical practice by identifying appropriate interventions based on specific gene mutations. For example, when an individual has obvious gene mutations related to FF, ICSI is recommended instead of IVF. However, in the case of genetic defects such as phospholipase C zeta1 (PLCZ1) , actin-like7A (ACTL7A) , actin-like 9 (ACTL9) , and IQ motif-containing N (IQCN) , ICSI may also fail to fertilize. We can consider artificial oocyte activation technology with ICSI to improve fertilization rate and reduce monetary and time costs. In the future, fertility is expected to be improved or restored by interfering with or supplementing the relevant genes. [ABSTRACT FROM AUTHOR]

To respond to emergencies in a timely manner, emergency engineering equipment has been an important tool to implement emergency strategies. However, random failures of the equipment may occur during operation. Therefore, appropriate maintenance and spare parts inventory strategies are crucial to ensure the smooth operation of the equipment. Furthermore, the urgency degree of emergencies varies in practice. Nevertheless, existing studies rarely consider the impact of urgency degree and demand priorities on the service order of the equipment. To bridge the research gaps, this paper establishes a joint optimization model of maintenance and spare parts inventory strategies for emergency engineering equipment considering demand priorities. The proposed model includes two types of emergency engineering equipment with different service rates. The more urgent demand can be fulfilled by the equipment with a higher priority. Corrective maintenance and spare parts inventory policies are simultaneously performed for the equipment. The Markov process imbedding method is utilized to derive the probabilistic indexes of the system. To maximize the system availability, the number of maintenance engineers and the spare parts inventory strategy is optimized via the construction of the joint optimization model. The optimal solution for the optimization problem is obtained using the branch-and-bound method. Finally, this study presents practical examples to verify the effectiveness of the model and methods. [ABSTRACT FROM AUTHOR]