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152. Calorimetric lateral flow immunoassay detection platform based on the photothermal effect of gold nanocages with high sensitivity, specificity, and accuracy

Author

Hu X, Wan J, Peng X, Zhao H, Shi D, Mai L, Yang H, Zhao Y, and Yang X

Subjects
lateral flow assays (LFA), gold nanocages, photothermal effect, alpha-fetoprotein (AFP), zearalenone (ZEN), Medicine (General), R5-920
Abstract

Xiaoyan Hu,1 Jiangshan Wan,2,3 Xiaole Peng,2,3 Hao Zhao,1,3 Dingwen Shi,1,3 Liyi Mai,2 Hai Yang,1 Yanbing Zhao,1,3 Xiangliang Yang1 1National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of China; 2Institute of Consun Co. For Chinese Medicine in Kidney Diseases, C. Consum Pharmaceutical Group, Shenzhen 518000, People’s Republic of China; 3Shenzhen Institute of Huazhong University of Science and Technology, Shenzhen 518057, People’s Republic of ChinaCorrespondence: Hai YangNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of ChinaEmail yanghai@hust.edu.cnYanbing ZhaoNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of ChinaEmail zhaoyb@hust.edu.cnBackground: Lateral flow assays (LFA) play an increasingly important role in the rapid detection of various pathogens, pollutants, and toxins.Purpose: To overcome the drawbacks of low sensitivity and poor quantification in LFA, we developed a new calorimetric LFA (CLFA) using gold nanocages (GNCs) due to their high photothermal conversion efficiency, good stability of photophysical properties, and stronger penetrating ability of NIR light.Methods: Thiol-polyethylene glycol-succinyl imide ester (HS-PEG-NHS) was modified onto GNCs, and the complex was conjugated with an antibody. Subsequently, the antibody-conjugated GNCs were analyzed by UV/Vis spectrophotometer, transmission electron microscope, high-resolution transmission electron microscope with energy dispersive spectrometer, dynamic light scattering instrument, and Atom force microscope. The GNC-based CLFA of alpha-fetoprotein (AFP) and zearalenone (ZEN), a food toxin, required nitrocellulose strips, a NIR laser source, and an infrared camera.Results: The GNC-labeled CLFA platform technique exhibited detection sensitivity, qualitative specificity, and quantitative accuracy. The superior performance of the technique was evident both in sandwich format detection of biomacromolecules (eg, AFP protein) or competitive format detection of small molecules (eg, ZEN). After optimizing various test parameters, GNC-labeled CLFA provided ca. 5-6-fold enhanced sensitivity, higher correlativity (R2>0.99), and more favorable recovery (82–115%) when compared with visual LFA.Conclusion: GNC-labeled CLFA may be a promising detection platform with high sensitivity, specificity, and precision.Keywords: lateral flow assays, LFA, gold nanocages, photothermal effect, alpha-fetoprotein, AFP, zearalenone, ZEN

Published
2019

153. A novel LARCassigner3 classification predicts outcomes in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy: a retrospective training and validation analysis

Author

Zhang J, Shen L, Deng Y, Sun X, Wang Y, Yao Y, Zhang H, Zou W, Zhang Z, Wan J, Yang L, and Zhu J

Subjects
Prognostic marker, Locally Advanced Rectal Cancer, Neoadjuvant chemoradiotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Jing Zhang,1,2,* Lijun Shen,1,2,* Yun Deng,1,2 Xiaoyang Sun,1,2 Yaqi Wang,1,2 Ye Yao,1,2 Hui Zhang,1,2 Wei Zou,1,2 Zhiyuan Zhang,1,2 Juefeng Wan,1,2 Lifeng Yang,1,2 Ji Zhu,1,2 Zhen Zhang1,21Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China*These authors contributed equally to this workPurpose: To build and validate a predictive model of outcome for patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy.Materials and methods: We developed a LARCassigner3 classifier based on tumor and paired normal tissues of patients treated with neoadjuvant chemoradiation and surgery from January 2007 to December 2012 in Fudan University Shanghai Cancer Center. Excluding 23 pairs of tissues failed in the RNA quality test, rested 197 patients were divided into discovery (n=98) and validation (n=99) cohorts randomly. Median follow-up time was 58 months. We used the Kaplan–Meier method to estimate disease-free survival (DFS), overall survival (OS), local recurrent, and distant metastatic rate We constructed a multivariate Cox model to identify the variables independently associated with progression-free and OS.Results: We identified three classifier genes related to relevant colorectal cancer features (CXCL9, SFRP2, and CD44) that formed the LARCassigner3 classifier assay. In the discovery set, the median DFS was 48.1 months (95% confidence interval (CI) 47.3–49.5) in the low-risk group and 23.4 months (95% CI 22.1–24.8) in the high-risk group (p=0.0134); the median OS was 39.2 months (95% CI 38.4–40.3) in the high-risk group and 19.1 months (95% CI 18.3–20.7) in the low-risk group (p=0.0134); 5-year distant metastasis was 13.9% (95% CI 9.0–21.3) in the low-risk group and 49.8% (95% CI 38.7–60.9) in the high-risk group (p=0.0072). Additionally, the different responses to neoadjuvant chemoradiotherapy and the LARCassigner3 low-risk and high-risk groups was statistically significant (p=0.004) in the discovery cohort. Similar results were obtained in the internal evaluation cohort.Conclusions: Patients with LARCassigner3 low-risk tumors were associated with a good prognosis. The clinical utility of using LARCassigner3 subtyping for the identification of patients for neoadjuvant chemoradiotherapy requires validation in dependent clinical trial cohorts.Keywords: prognostic marker, locally advanced rectal cancer, neoadjuvant chemoradiotherapy

Published
2019

154. Long noncoding RNA FEZF1-AS1 promotes the motility of esophageal squamous cell carcinoma through Wnt/β-catenin pathway

Author

Yang L, Ye Y, Chu J, Jia J, Qu Y, Sun T, Yin H, Ming L, Wan J, and He F

Subjects
Esophageal squamous cell carcinoma, LncRNA, FEZF1-AS1, Biological function, β-catenin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Lijun Yang,* Yafei Ye,* Jie Chu, Jinlin Jia, Yunhui Qu, Ting Sun, Huiqing Yin, Liang Ming, Junhu Wan, Fucheng HeDepartment of Medical Laboratory, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China*These authors contributed equally to this workBackground: Long noncoding RNAs (lncRNAs), a class of noncoding RNA nucleotides >200 bp, has been demonstrated to play vital role in the development of cancer. FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) has been reported as an lncRNA which acts as a tumor-promoting effect in some cancers. However, the role of it in esophageal squamous cell carcinoma (ESCC) and its potential regulatory mechanism was unclear now.Methods: qRT-PCR was used to detect the levels of FEZF1-AS1 and mRNA CTNNB1 (β-catenin) in ESCC tissues and cells. Cell transfection experiments were used to knock down or overexpress the level of FEZF1-AS1 in EC1 and EC9706 cell lines. WST-1 assays, cell cycle assays, scratch wound assays, migration, and invasion assays were used to evaluate the function of FEZF1-AS1 in ESCC progression.Results: FEZF1-AS1 was remarkably upregulated in ESCC tissues and cell lines. Silencing of FEZF1-AS1 significantly inhibited the migration and invasion of ESCC cells, while overexpression of FEZF1-AS1 notably accelerated ESCC migration and invasion. Meanwhile, the levels of FEZF1-AS1 had no effect on ESCC cell proliferation and cell cycle. We also found that β-catenin was upregulated in ESCC tissues, and the level of it was positively correlated with the expression of FEZF1-AS1. Silencing of FEZF1-AS1 could decrease the mRNA and protein level of β-catenin, while overexpression FEZF1-AS1 could lead to the contrary.Conclusion: Our results suggested that the expression of lncRNA FEZF1-AS1 played an important role in ESCC progression, especially the motility of the tumor. FEZF1-AS1 may provide us with a new sight for ESCC treatment.Keywords: esophageal squamous cell carcinoma, lncRNA, FEZF1-AS1, biological function, β-catenin

Published
2019

155. Comparison of the Effects of Sufentanil and Fentanyl on Postoperative Sleep Quality of Children Undergoing Tonsillectomy and Adenotomy: A Randomized Controlled Trial [Corrigendum]

Author

Li Y, Song B, Li Z, Wan J, Luo M, Wei W, and Zhu J

Subjects
postoperative sleep quality, pain, sufentanil, fentanyl, children, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Li Y, Song B, Li Z, et al. Nat Sci Sleep. 2021;13:821–828. On page 823, Results, The Comparison of Demographic Characteristics of the Two Groups section, line 3, the text “duration of the operation (min) (P = 0.062)” should read “duration of surgery (min) (P = 0.517)”. Table 1 on page 824, the Duration of surgery (min) row is incorrect. The correct Table 1 is shown in Download Article. Read the original article

Published
2021

156. Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration

Author

Huang Y, Hu L, Huang S, Xu W, Wan J, Wang D, Zheng G, and Xia Z

Subjects
albumin, curcumin, nanoparticles, galactosylated, hepatocellular carcinoma, Medicine (General), R5-920
Abstract

Yike Huang,1 Lu Hu,2 Shan Huang,1 Wanjun Xu,1 Jingyuan Wan,2 Dandan Wang,1 Guocan Zheng,3 Zhining Xia1 1Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University, Chongqing, China; 2Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, China; 3Analytical and Testing Center, Chongqing University, Chongqing, China Background: The main objective of this study was to develop novel BSA nanoparticles (BSA NPs) for improving the bioavailability of curcumin as an anticancer drug, and those BSA NPs were galactosylated for forming the curcumin-loaded galactosylated BSA nanoparticles (Gal-BSA-Cur NPs), thus enhancing their ability to target asialoglycoprotein receptor (ASGPR) overexpressed on hepatocellular carcinoma (HCC) cells. Materials and methods: Gal-BSA-Cur NPs were prepared by the desolvation method and showed a spherical shape and well distribution with the average particle size of 116.24 nm. Results: In vitro drug release assay exhibited that Gal-BSA-Cur NPs had higher release rates and improved the curcumin solubility. Cell uptake studies confirmed that Gal-BSA-Cur NPs could selectively recognize receptors on the surface of HCC (HepG2) cells and improve internalization ability of drug compared with BSA NPs-loaded curcumin (BSA-Cur NPs), which might be due to high affinity to galactose. Further, the effects of Gal-BSA-Cur NPs were evaluated by cytotoxicity assay, crystal violet assay, cell apoptosis assay, and wound healing assay, respectively, which revealed that Gal-BSA-Cur NPs could inhibit HepG2 cells proliferation, induce cell apoptosis, and inhibit cell migration. Conclusion: Immunofluorescence staining has proved that the effects of Gal-BSA-Cur NPs related to the suppression of the nuclear factor κB-p65 (NF-κB-p65) expression in HepG2 cell nucleus. Therefore, these results indicate that novel Gal-BSA-Cur NPs are potential candidates for targeted curcumin delivery to HCC cells. Keywords: albumin, curcumin, nanoparticles, galactosylated, hepatocellular carcinoma

Published
2018

157. A Dual Gate Spin Field Effect Transistor With Very Low Switching Voltage and Large ON-to-OFF Conductance Ratio

Author

Wan, J., Cahay, M., and Bandyopadhyay, S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Other Condensed Matter
Abstract

We propose and analyze a novel dual-gate Spin Field Effect Transistor (SpinFET) with half-metallic ferromagnetic source and drain contacts. The transistor has two gate pads that can be biased independently. It can be switched ON or OFF with a few mV change in the differential bias between the two pads, resulting in extremely low dynamic power dissipation during switching. The ratio of ON to OFF conductance remains fairly large (~ 60) up to a temperature of 10 K. This device also has excellent inverter characteristics, making it attractive for applications in low power and high density Boolean logic circuits.

Published
2007
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158. A Digital Switch and Femto-Tesla Magnetic Field Sensor Based on Fano Resonance in a Spin Field Effect Transistor

Author

Wan, J., Cahay, M., and Bandyopadhyay, S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Other Condensed Matter
Abstract

We show that a Spin Field Effect Transistor, realized with a semiconductor quantum wire channel sandwiched between half-metallic ferromagnetic contacts, can have Fano resonances in the transmission spectrum. These resonances appear because the ferromagnets are half-metallic, so that the Fermi level can be placed above the majority but below the minority spin band. In that case, the majority spins will be propagating, but the minority spins will be evanescent. At low temperatures, the Fano resonances can be exploited to implement a digital binary switch that can be turned on or off with a very small gate voltage swing of few tens of microvolts, leading to extremely small dynamic power dissipation during switching. An array of 500,000 x 500,000 such transistors can detect ultrasmall changes in a magnetic field with a sensitivity of 1 femto-Tesla/sqrt{Hz}, if each transistor is biased near a Fano resonance.

Published
2007
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159. Observation of abnormal suppression of f0(980) production in p–Pb collisions at [formula omitted] = 5.02 TeV

Author

Acharya, S., Adamová, D., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S.U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H.M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A.R., Altsybeev, I., Alvarado, J.R., Anaam, M.N., Andrei, C., Andreou, N., Andronic, A., Andronov, E., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J.G.M.C.A., Arsene, I.C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M.D., Baba, H., Badalà, A., Bae, J., Baek, Y.W., Bai, X., Bailhache, R., Bailung, Y., Bala, R., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G.G., Barnby, L.S., Barreau, E., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J.L., Bearden, I.G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A.D.C., Bellini, F., Bellwied, R., Belokurova, S., Beltran, L.G.E., Beltran, Y.A.V., Bencedi, G., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M.G., Betev, L., Bhaduri, P.P., Bhasin, A., Bhat, M.A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Bigot, A.P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J.T., Blau, D., Blidaru, M.B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Boi, S., Bok, J., Boldizsár, L., Bombara, M., Bond, P.M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A.G., Bossi, H., Botta, E., Bouziani, Y.E.M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G.E., Buckland, M.D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Burmasov, N., Buthelezi, Z., Bylinkin, A., Bysiak, S.A., Cabanillas Noris, J.C., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J.M.M., Camerini, P., Canedo, F.D.M., Cantway, S.L., Carabas, M., Carballo, A.A., Carnesecchi, F., Caron, R., Carvalho, L.A.D., Castillo Castellanos, J., Catalano, F., Ceballos Sanchez, C., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhyay, S., Cheng, T., Cheshkov, C., Cheynis, B., Chibante Barroso, V., Chinellato, D.D., Chizzali, E.S., Cho, J., Cho, S., Chochula, P., Choudhury, D., Christakoglou, P., Christensen, C.H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Ciupek, M.R., Clai, G., Colamaria, F., Colburn, J.S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J.G., Coquet, M.L., Cortese, P., Cosentino, M.R., Costa, F., Costanza, S., Cot, C., Crkovská, J., Crochet, P., Cruz-Torres, R., Cui, P., Dainese, A., Danisch, M.C., Danu, A., Das, P., Das, S., Dash, A.R., Dash, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Martin, C., De Pasquale, S., Deb, R., Del Grande, R., Dello Stritto, L., Deng, W., Dhankher, P., Di Bari, D., Di Mauro, A., Diab, B., Diaz, R.A., Dietel, T., Ding, Y., Ditzel, J., Divià, R., Dixit, D.U., Djuvsland, Ø., Dmitrieva, U., Dobrin, A., Dönigus, B., Dubinski, J.M., Dubla, A., Dudi, S., Dupieux, P., Durkac, M., Dzalaiova, N., Eder, T.M., Ehlers, R.J., Eisenhut, F., Ejima, R., Elia, D., Erazmus, B., Ercolessi, F., Espagnon, B., Eulisse, G., Evans, D., Evdokimov, S., Fabbietti, L., Faggin, M., Faivre, J., Fan, F., Fan, W., Fantoni, A., Fasel, M., Feliciello, A., Feofilov, G., Fernández Téllez, A., Ferrandi, L., Ferrer, M.B., Ferrero, A., Ferrero, C., Ferretti, A., Feuillard, V.J.G., Filova, V., Finogeev, D., Fionda, F.M., Flatland, E., Flor, F., Flores, A.N., Foertsch, S., Fokin, I., Fokin, S., Fragiacomo, E., Frajna, E., Fuchs, U., Funicello, N., Furget, C., Furs, A., Fusayasu, T., Gaardhøje, J.J., Gagliardi, M., Gago, A.M., Gahlaut, T., Galvan, C.D., Gangadharan, D.R., Ganoti, P., Garabatos, C., García Chávez, T., Garcia-Solis, E., Gargiulo, C., Gasik, P., Gautam, A., Gay Ducati, M.B., Germain, M., Ghimouz, A., Ghosh, C., Giacalone, M., Gioachin, G., Giubellino, P., Giubilato, P., Glaenzer, A.M.C., Glässel, P., Glimos, E., Goh, D.J.Q., Gonzalez, V., Gordeev, P., Gorgon, M., Goswami, K., Gotovac, S., Grabski, V., Graczykowski, L.K., Grecka, E., Grelli, A., Grigoras, C., Grigoriev, V., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J.F., Grosso, R., Grund, D., Grunwald, N.A., Guardiano, G.G., Guernane, R., Guilbaud, M., Gulbrandsen, K., Gündem, T., Gunji, T., Guo, W., Gupta, A., Gupta, R., Gwizdziel, K., Gyulai, L., Hadjidakis, C., Haider, F.U., Haidlova, S., Haldar, M., Hamagaki, H., Hamdi, A., Han, Y., Hanley, B.G., Hannigan, R., Hansen, J., Harris, J.W., Harton, A., Hartung, M.V., Hassan, H., Hatzifotiadou, D., Hauer, P., Havener, L.B., Hellbär, E., Helstrup, H., Hemmer, M., Herman, T., Herrera Corral, G., Herrmann, F., Herrmann, S., Hetland, K.F., Heybeck, B., Hillemanns, H., Hippolyte, B., Hoffmann, F.W., Hofman, B., Hong, G.H., Horst, M., Horzyk, A., Hou, Y., Hristov, P., Hughes, C., Huhn, P., Huhta, L.M., Humanic, T.J., Hutson, A., Hutter, D., Hwang, M.C., Ilkaev, R., Ilyas, H., Inaba, M., Innocenti, G.M., Ippolitov, M., Isakov, A., Isidori, T., Islam, M.S., Ivanov, M., Ivanov, V., Iversen, K.E., Jablonski, M., Jacak, B., Jacazio, N., Jacobs, P.M., Jadlovska, S., Jadlovsky, J., Jaelani, S., Jahnke, C., Jakubowska, M.J., Janik, M.A., Janson, T., Ji, S., Jia, S., Jimenez, A.A.P., Jonas, F., Jones, D.M., Jowett, J.M., Jung, J., Jung, M., Junique, A., Jusko, A., Kaewjai, J., Kalinak, P., Kalteyer, A.S., Kalweit, A., Karasu Uysal, A., Karatovic, D., Karavichev, O., Karavicheva, T., Karczmarczyk, P., Karpechev, E., Karwowska, M.J., Kebschull, U., Keidel, R., Keijdener, D.L.D., Keil, M., Ketzer, B., Khade, S.S., Khan, A.M., Khan, S., Khanzadeev, A., Kharlov, Y., Khatun, A., Khuntia, A., Khuranova, Z., Kileng, B., Kim, B., Kim, C., Kim, D.J., Kim, E.J., Kim, J., Kim, M., Kim, S., Kim, T., Kimura, K., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kitowski, J.P., Klay, J.L., Klein, J., Klein, S., Klein-Bösing, C., Kleiner, M., Klemenz, T., Kluge, A., Kobdaj, C., Kollegger, T., Kondratyev, A., Kondratyeva, N., Konig, J., Konigstorfer, S.A., Konopka, P.J., Kornakov, G., Korwieser, M., Koryciak, S.D., Kotliarov, A., Kovacic, N., Kovalenko, V., Kowalski, M., Kozhuharov, V., Králik, I., Kravčáková, A., Krcal, L., Krivda, M., Krizek, F., Krizkova Gajdosova, K., Kroesen, M., Krüger, M., Krupova, D.M., Kryshen, E., Kučera, V., Kuhn, C., Kuijer, P.G., Kumaoka, T., Kumar, D., Kumar, L., Kumar, N., Kumar, S., Kundu, S., Kurashvili, P., Kurepin, A., Kurepin, A.B., Kuryakin, A., Kushpil, S., Kuskov, V., Kutyla, M., Kweon, M.J., Kwon, Y., La Pointe, S.L., La Rocca, P., Lakrathok, A., Lamanna, M., Landou, A.R., Langoy, R., Larionov, P., Laudi, E., Lautner, L., Lavicka, R., Lea, R., Lee, H., Legrand, I., Legras, G., Lehrbach, J., Lelek, T.M., Lemmon, R.C., León Monzón, I., Lesch, M.M., Lesser, E.D., Lévai, P., Li, X., Liang-gilman, B.E., Lien, J., Lietava, R., Likmeta, I., Lim, B., Lim, S.H., Lindenstruth, V., Lindner, A., Lippmann, C., Liu, D.H., Liu, J., Liveraro, G.S.S., Lofnes, I.M., Loizides, C., Lokos, S., Lömker, J., Loncar, P., Lopez, X., López Torres, E., Lu, P., Lugo, F.V., Luhder, J.R., Lunardon, M., Luparello, G., Ma, Y.G., Mager, M., Maire, A., Majerz, E.M., Makariev, M.V., Malaev, M., Malfattore, G., Malik, N.M., Malik, Q.W., Malik, S.K., Malinina, L., Mallick, D., Mallick, N., Mandaglio, G., Mandal, S.K., Manko, V., Manso, F., Manzari, V., Mao, Y., Marcjan, R.W., Margagliotti, G.V., Margotti, A., Marín, A., Markert, C., Martinengo, P., Martínez, M.I., Martínez García, G., Martins, M.P.P., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Massen, O., Mastroserio, A., Matonoha, O., Mattiazzo, S., Matyja, A., Mayer, C., Mazuecos, A.L., Mazzaschi, F., Mazzilli, M., Mdhluli, J.E., Melikyan, Y., Menchaca-Rocha, A., Mendez, J.E.M., Meninno, E., Menon, A.S., Meres, M., Miake, Y., Micheletti, L., Mihaylov, D.L., Mikhaylov, K., Miśkowiec, D., Modak, A., Mohanty, B., Mohisin Khan, M., Molander, M.A., Monira, S., Mordasini, C., Moreira De Godoy, D.A., Morozov, I., Morsch, A., Mrnjavac, T., Muccifora, V., Muhuri, S., Mulligan, J.D., Mulliri, A., Munhoz, M.G., Munzer, R.H., Murakami, H., Murray, S., Musa, L., Musinsky, J., Myrcha, J.W., Naik, B., Nambrath, A.I., Nandi, B.K., Nania, R., Nappi, E., Nassirpour, A.F., Nath, A., Nattrass, C., Naydenov, M.N., Neagu, A., Negru, A., Nekrasova, E., Nellen, L., Nepeivoda, R., Nese, S., Neskovic, G., Nicassio, N., Nielsen, B.S., Nielsen, E.G., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Noh, S., Nomokonov, P., Norman, J., Novitzky, N., Nowakowski, P., Nyanin, A., Nystrand, J., Oh, S., Ohlson, A., Okorokov, V.A., Oleniacz, J., Onnerstad, A., Oppedisano, C., Ortiz Velasquez, A., Otwinowski, J., Oya, M., Oyama, K., 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R.J.G., Vande Vyvre, P., Varga, D., Varga, Z., Vargas Torres, P., Vasileiou, M., Vasiliev, A., Vázquez Doce, O., Vazquez Rueda, O., Vechernin, V., Vercellin, E., Vergara Limón, S., Verma, R., Vermunt, L., Vértesi, R., Verweij, M., Vickovic, L., Vilakazi, Z., Villalobos Baillie, O., Villani, A., Vinogradov, A., Virgili, T., Virta, M.M.O., Vislavicius, V., Vodopyanov, A., Volkel, B., Völkl, M.A., Voloshin, S.A., Volpe, G., von Haller, B., Vorobyev, I., Vozniuk, N., Vrláková, J., Wan, J., Wang, C., Wang, D., Wang, Y., Wegrzynek, A., Weiglhofer, F.T., Wenzel, S.C., Wessels, J.P., Wiechula, J., Wikne, J., Wilk, G., Wilkinson, J., Willems, G.A., Windelband, B., Winn, M., Wright, J.R., Wu, W., Wu, Y., Xiong, Z., Xu, R., Yadav, A., Yadav, A.K., Yalcin, S., Yamaguchi, Y., Yang, S., Yano, S., Yeats, E.R., Yin, Z., Yoo, I.-K., Yoon, J.H., Yu, H., Yuan, S., Yuncu, A., Zaccolo, V., Zampolli, C., Zanone, F., Zardoshti, N., Zarochentsev, A., Závada, P., Zaviyalov, N., Zhalov, M., Zhang, B., Zhang, C., Zhang, L., Zhang, M., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, M., Zherebchevskii, V., Zhi, Y., Zhong, C., Zhou, D., Zhou, Y., Zhu, J., Zhu, Y., Zugravel, S.C., and Zurlo, N.

Published
2024
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160. Can a non-ideal metal ferromagnet inject spin into a semiconductor with 100% efficiency without a tunnel barrier?

Author

Wan, J., Cahay, M., and Bandyopadhyay, S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Current understanding of spin injection tells us that a metal ferromagnet can inject spin into a semiconductor with 100% efficiency if either the ferromagnet is an ideal half metal with 100% spin polarization, or there exists a suitable tunnel barrier at the interface. In this paper, we show that, at absolute zero temperature, 100% spin injection efficiency from a non-ideal metal ferromagnet into a semiconductor quantum wire can be reached at certain injection energies, without a tunnel barrier, provided there is an axial magnetic field along the direction of current flow as well as a spin orbit interaction in the semiconductor. At these injection energies, spin is injected only from the majority spin band of the ferromagnetic contact, resulting in 100% spin injection efficiency. This happens because of the presence of antiresonances in the transmission coefficient of the minority spins when their incident energies coincide with Zeeman energy states in the quantum wire. At absolute zero and below a critical value of the axial magnetic field, there are two distinct Zeeman energy states and therefore two injection energies at which ideal spin filtering is possible; above the critical magnetic field there is only one such injection energy. The spin injection efficiency rapidly decreases as the temperature increases. The rate of decrease is slower when the magnetic field is above the critical value. The appropriate choice of semiconductor materials and structures necessary to maintain a large spin injection efficiency at elevated temperatures is discussed.

Published
2006

165. Creating Büchi Automata for Multi-valued Model Checking

Author

Vijzelaar, Stefan J. J., Fokkink, Wan J., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Bouajjani, Ahmed, editor, and Silva, Alexandra, editor

Published
2017
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169. Spatial variations in the N2O emissions and denitrification potential of riparian buffer strips in a contaminated urban river

Author

Huang, X, Zhang, T, Li, W, Wan, J, and Dahlgren, RA

Subjects
N2O emission, denitrification potential, riparian buffer strips, nitrate removal, Marine Biology & Hydrobiology, Chemical Sciences, Environmental Sciences
Abstract

Spatial variations in the N2O emissions and denitrification potential of riparian buffer strips (RBS) in a polluted river were examined. The river received large pollutant inputs from urban runoff and wastewater discharge, resulting in impaired water quality in the river and downstream reservoir. The potential for nitrogen removal by RBS was evaluated by measuring in situ N2O emission fluxes in static closed chambers and sediment denitrification potentials with acetylene inhibition techniques. The results showed that N2O emission fluxes decreased from the upstream (16.39 μg/(m2·h)) to downstream (0.30 μg/(m2·h)) sites and from the water body to upland sites. The trend in decreasing N2O emission fluxes in the downstream direction was mainly associated with sediment/soil textures (clay loam→sandy soil) and sediment/soil water contents and was also related to the vegetation along the RBS and nutrients in the sediments/soils. The correlation coefficient was highest (r=0.769) between the N2O emission flux and sediment/soil water content. Sediment/soil denitrification potentials under N-amended and ambient conditions were higher (highest 32.86 mg/(kg·h)) for the upstream sites, which were consistent with in situ N2O flux rates. © 2013 Copyright Taylor and Francis Group, LLC.

Published
2013

172. Modification of charged-particle jets in event-shape engineered Pb–Pb collisions at [formula omitted] TeV

Author

Acharya, S., Adamová, D., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S.U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H.M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A.R., Altsybeev, I., Alvarado, J.R., Anaam, M.N., Andrei, C., Andreou, N., Andronic, A., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J.G.M.C.A., Arsene, I.C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M.D., Baba, H., Badalà, A., Bae, J., Baek, Y.W., Bai, X., Bailhache, R., Bailung, Y., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbera, R., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G.G., Barnby, L.S., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., 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Zurlo, N.

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2024
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173. Skewness and kurtosis of mean transverse momentum fluctuations at the LHC energies

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Acharya, S., Adamová, D., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S.U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H.M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altamura, A.R., Altsybeev, I., Alvarado, J.R., Anaam, M.N., Andrei, C., Andreou, N., Andronic, A., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J.G.M.C.A., Arsene, I.C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M.D., Baba, H., Badalà, A., Bae, J., Baek, Y.W., Bai, X., Bailhache, R., Bailung, Y., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbera, R., Barile, F., Barioglio, L., Barlou, M., Barman, B., Barnaföldi, G.G., Barnby, L.S., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J.L., Bearden, I.G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A.D.C., Bellini, F., Bellwied, R., Belokurova, S., Beltran, Y.A.V., Bencedi, G., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M.G., Betev, L., Bhaduri, P.P., Bhasin, A., Bhat, M.A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Biernat, J., Bigot, A.P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J.T., Blau, D., Blidaru, M.B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bogdanov, A., Boi, S., Bok, J., Boldizsár, L., Bombara, M., Bond, P.M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A.G., Bossi, H., Botta, E., Bouziani, Y.E.M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G.E., Buckland, M.D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Burmasov, N., Buthelezi, Z., Bylinkin, A., Bysiak, S.A., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J.M.M., Camerini, 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C., García Chávez, T., Garcia-Solis, E., Gargiulo, C., Gasik, P., Gautam, A., Gay Ducati, M.B., Germain, M., Ghimouz, A., Ghosh, C., Giacalone, M., Gioachin, G., Giubellino, P., Giubilato, P., Glaenzer, A.M.C., Glässel, P., Glimos, E., Goh, D.J.Q., Gonzalez, V., Gordeev, P., Gorgon, M., Goswami, K., Gotovac, S., Grabski, V., Graczykowski, L.K., Grecka, E., Grelli, A., Grigoras, C., Grigoriev, V., Grigoryan, S., Grosa, F., Grosse-Oetringhaus, J.F., Grosso, R., Grund, D., Grunwald, N.A., Guardiano, G.G., Guernane, R., Guilbaud, M., Gulbrandsen, K., Gündem, T., Gunji, T., Guo, W., Gupta, A., Gupta, R., Gwizdziel, K., Gyulai, L., Hadjidakis, C., Haider, F.U., Haidlova, S., Hamagaki, H., Hamdi, A., Han, Y., Hanley, B.G., Hannigan, R., Hansen, J., Haque, M.R., Harris, J.W., Harton, A., Hassan, H., Hatzifotiadou, D., Hauer, P., Havener, L.B., Heckel, S.T., Hellbär, E., Helstrup, H., Hemmer, M., Herman, T., Herrera Corral, G., Herrmann, F., Herrmann, S., Hetland, K.F., Heybeck, B., Hillemanns, H., Hippolyte, B., Hoffmann, F.W., Hofman, B., Hong, G.H., Horst, M., Horzyk, A., Hou, Y., Hristov, P., Hughes, C., Huhn, P., Huhta, L.M., Humanic, T.J., Hutson, A., Hutter, D., Ilkaev, R., Ilyas, H., Inaba, M., Innocenti, G.M., Ippolitov, M., Isakov, A., Isidori, T., Islam, M.S., Ivanov, M., Ivanov, V., Iversen, K.E., Jablonski, M., Jacak, B., Jacazio, N., Jacobs, P.M., Jadlovska, S., Jadlovsky, J., Jaelani, S., Jahnke, C., Jakubowska, M.J., Janik, M.A., Janson, T., Ji, S., Jia, S., Jimenez, A.A.P., Jonas, F., Jones, D.M., Jowett, J.M., Jung, J., Jung, M., Junique, A., Jusko, A., Kabus, M.J., Kaewjai, J., Kalinak, P., Kalteyer, A.S., Kalweit, A., Kaplin, V., Karasu Uysal, A., Karatovic, D., Karavichev, O., Karavicheva, T., Karczmarczyk, P., Karpechev, E., Kebschull, U., Keidel, R., Keijdener, D.L.D., Keil, M., Ketzer, B., Khade, S.S., Khan, A.M., Khan, S., Khanzadeev, A., Kharlov, Y., Khatun, A., Khuntia, A., Kileng, B., Kim, B., Kim, C., Kim, D.J., Kim, E.J., Kim, J., Kim, J.S., Kim, M., Kim, S., Kim, T., Kimura, K., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kitowski, J.P., Klay, J.L., Klein, J., Klein, S., Klein-Bösing, C., Kleiner, M., Klemenz, T., Kluge, A., Knospe, A.G., Kobdaj, C., Kollegger, T., Kondratyev, A., Kondratyeva, N., Kondratyuk, E., Konig, J., Konigstorfer, S.A., Konopka, P.J., Kornakov, G., Korwieser, M., Koryciak, S.D., Kotliarov, A., Kovalenko, V., Kowalski, M., Kozhuharov, V., Králik, I., Kravčáková, A., Krcal, L., Krivda, M., Krizek, F., Krizkova Gajdosova, K., Kroesen, M., Krüger, M., Krupova, D.M., Kryshen, E., Kučera, V., Kuhn, C., Kuijer, P.G., Kumaoka, T., Kumar, D., Kumar, L., Kumar, N., Kumar, S., Kundu, S., Kurashvili, P., Kurepin, A., Kurepin, A.B., Kuryakin, A., Kushpil, S., Kuskov, V., Kweon, M.J., Kwon, Y., La Pointe, S.L., La Rocca, P., Lakrathok, A., Lamanna, M., Landou, A.R., Langoy, R., Larionov, P., Laudi, E., Lautner, L., Lavicka, R., Lea, R., Lee, H., Legrand, I., Legras, G., Lehrbach, J., Lelek, T.M., Lemmon, R.C., León Monzón, I., Lesch, M.M., Lesser, E.D., Lévai, P., Li, X., Lien, J., Lietava, R., Likmeta, I., Lim, B., Lim, S.H., Lindenstruth, V., Lindner, A., Lippmann, C., Liu, D.H., Liu, J., Liveraro, G.S.S., Lofnes, I.M., Loizides, C., Lokos, S., Lömker, J., Loncar, P., Lopez, X., López Torres, E., Lu, P., Lugo, F.V., Luhder, J.R., Lunardon, M., Luparello, G., Ma, Y.G., Mager, M., Maire, A., Majerz, E.M., Makariev, M.V., Malaev, M., Malfattore, G., Malik, N.M., Malik, Q.W., Malik, S.K., Malinina, L., Mallick, D., Mallick, N., Mandaglio, G., Mandal, S.K., Manko, V., Manso, F., Manzari, V., Mao, Y., Marcjan, R.W., Margagliotti, G.V., Margotti, A., Marín, A., Markert, C., Martinengo, P., Martínez, M.I., Martínez García, G., Martins, M.P.P., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Massen, O., Mastroserio, A., Matonoha, O., Mattiazzo, S., Matyja, A., Mayer, C., Mazuecos, A.L., Mazzaschi, F., Mazzilli, M., Mdhluli, J.E., Melikyan, Y., Menchaca-Rocha, A., Mendez, J.E.M., Meninno, 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2024
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174. Measurements of inclusive J/ψ production at midrapidity and forward rapidity in Pb–Pb collisions at [formula omitted] = 5.02 TeV

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Acharya, S., Adamová, D., Adler, A., Aglieri Rinella, G., Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S.U., Ahuja, I., Akindinov, A., Al-Turany, M., Aleksandrov, D., Alessandro, B., Alfanda, H.M., Alfaro Molina, R., Ali, B., Alici, A., Alizadehvandchali, N., Alkin, A., Alme, J., Alocco, G., Alt, T., Altsybeev, I., Alvarado, J.R., Anaam, M.N., Andrei, C., Andronic, A., Anguelov, V., Antinori, F., Antonioli, P., Apadula, N., Aphecetche, L., Appelshäuser, H., Arata, C., Arcelli, S., Aresti, M., Arnaldi, R., Arneiro, J.G.M.C.A., Arsene, I.C., Arslandok, M., Augustinus, A., Averbeck, R., Azmi, M.D., Badalà, A., Bae, J., Baek, Y.W., Bai, X., Bailhache, R., Bailung, Y., Balbino, A., Baldisseri, A., Balis, B., Banerjee, D., Banoo, Z., Barbera, R., Barile, F., Barioglio, L., Barlou, M., Barnaföldi, G.G., Barnby, L.S., Barret, V., Barreto, L., Bartels, C., Barth, K., Bartsch, E., Bastid, N., Basu, S., Batigne, G., Battistini, D., Batyunya, B., Bauri, D., Bazo Alba, J.L., Bearden, I.G., Beattie, C., Becht, P., Behera, D., Belikov, I., Bell Hechavarria, A.D.C., Bellini, F., Bellwied, R., Belokurova, S., Bencedi, G., Beole, S., Berdnikov, Y., Berdnikova, A., Bergmann, L., Besoiu, M.G., Betev, L., Bhaduri, P.P., Bhasin, A., Bhat, M.A., Bhattacharjee, B., Bianchi, L., Bianchi, N., Bielčík, J., Bielčíková, J., Biernat, J., Bigot, A.P., Bilandzic, A., Biro, G., Biswas, S., Bize, N., Blair, J.T., Blau, D., Blidaru, M.B., Bluhme, N., Blume, C., Boca, G., Bock, F., Bodova, T., Bogdanov, A., Boi, S., Bok, J., Boldizsár, L., Bombara, M., Bond, P.M., Bonomi, G., Borel, H., Borissov, A., Borquez Carcamo, A.G., Bossi, H., Botta, E., Bouziani, Y.E.M., Bratrud, L., Braun-Munzinger, P., Bregant, M., Broz, M., Bruno, G.E., Buckland, M.D., Budnikov, D., Buesching, H., Bufalino, S., Buhler, P., Buthelezi, Z., Bylinkin, A., Bysiak, S.A., Cai, M., Caines, H., Caliva, A., Calvo Villar, E., Camacho, J.M.M., Camerini, P., Canedo, F.D.M., Cantway, S.L., Carabas, M., Carballo, A.A., Carnesecchi, F., Caron, R., Carvalho, L.A.D., Castillo Castellanos, J., Catalano, F., Ceballos Sanchez, C., Chakaberia, I., Chakraborty, P., Chandra, S., Chapeland, S., Chartier, M., Chattopadhyay, S., Cheng, T., Cheshkov, C., Cheynis, B., Chibante Barroso, V., Chinellato, D.D., Chizzali, E.S., Cho, J., Cho, S., Chochula, P., Christakoglou, P., Christensen, C.H., Christiansen, P., Chujo, T., Ciacco, M., Cicalo, C., Cindolo, F., Ciupek, M.R., Clai, G., Colamaria, F., Colburn, J.S., Colella, D., Colocci, M., Concas, M., Conesa Balbastre, G., Conesa del Valle, Z., Contin, G., Contreras, J.G., Coquet, M.L., Cormier, T.M., Cortese, P., Cosentino, M.R., Costa, F., Costanza, S., Cot, C., Crkovská, J., Crochet, P., Cruz-Torres, R., Cui, P., Dainese, A., Danisch, M.C., Danu, A., Das, P., Das, S., Dash, A.R., Dash, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Martin, C., De Pasquale, S., Deb, R., Deb, S., Deja, K.R., Del Grande, R., Dello 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Lévai, P., Li, X., Li, X.L., Lien, J., Lietava, R., Likmeta, I., Lim, B., Lim, S.H., Lindenstruth, V., Lindner, A., Lippmann, C., Liu, A., Liu, D.H., Liu, J., Liveraro, G.S.S., Lofnes, I.M., Loizides, C., Lokos, S., Lomker, J., Loncar, P., Lopez, J.A., Lopez, X., López Torres, E., Lu, P., Luhder, J.R., Lunardon, M., Luparello, G., Ma, Y.G., Mager, M., Maire, A., Makariev, M.V., Malaev, M., Malfattore, G., Malik, N.M., Malik, Q.W., Malik, S.K., Malinina, L., Mallick, D., Mallick, N., Mandaglio, G., Mandal, S.K., Manko, V., Manso, F., Manzari, V., Mao, Y., Marcjan, R.W., Margagliotti, G.V., Margotti, A., Marín, A., Markert, C., Martinengo, P., Martínez, M.I., Martínez García, G., Martins, M.P.P., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Mastroserio, A., Matonoha, O., Mattiazzo, S., Matuoka, P.F.T., Matyja, A., Mayer, C., Mazuecos, A.L., Mazzaschi, F., Mazzilli, M., Mdhluli, J.E., Mechler, A.F., Melikyan, Y., Menchaca-Rocha, A., Meninno, E., Menon, A.S., Meres, M., Mhlanga, 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Published
2024
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175. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling.

Author

Zhixuan Loh, Jennifer Simpson, Ashik Ullah, Vivian Zhang, Wan J Gan, Jason P Lynch, Rhiannon B Werder, Al Amin Sikder, Katie Lane, Choon Boon Sim, Enzo Porrello, Stuart B Mazzone, Peter D Sly, Raymond J Steptoe, Kirsten M Spann, Maria B Sukkar, John W Upham, and Simon Phipps

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as observed in asthma. Severe respiratory viral infections in infancy predispose to later asthma, however, the processes that mediate tissue damage-induced type-2 inflammation and the origins of airway remodelling remain ill-defined. Here, using a preclinical mouse model of viral bronchiolitis, we find that increased epithelial and mesenchymal high-mobility group box 1 (HMGB1) expression is associated with increased numbers of IL-13-producing type-2 innate lymphoid cell (ILC2s) and the expansion of the airway smooth muscle (ASM) layer. Anti-HMGB1 ablated lung ILC2 numbers and ASM growth in vivo, and inhibited ILC2-mediated ASM cell proliferation in a co-culture model. Furthermore, we identified that HMGB1/RAGE (receptor for advanced glycation endproducts) signalling mediates an ILC2-intrinsic IL-13 auto-amplification loop. In summary, therapeutic targeting of the HMGB1/RAGE signalling axis may act as a novel asthma preventative by dampening ILC2-mediated type-2 inflammation and associated ASM remodelling.

Published
2020
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178. Fatal adverse events with molecular targeted agents in the treatment of advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials

Author

Li X, Wan J, Wu Z, Tu J, Hu Y, Wu S, and Lou L

Subjects
hepatocellular cancer, fatal adverse events, randomized controlled trials, meta-analysis, targeted agents, Therapeutics. Pharmacology, RM1-950
Abstract

Xiaofei Li,1 Jia Wan,2 Zhenping Wu,3 Juncai Tu,1 Yongtao Hu,1 Shuang Wu,1 Lianqing Lou1 1Department of Infectious Diseases, Yiwu Central Hospital, Yiwu, China; 2The First Hospital of Nanchang, Nanchang, China; 3Gastroenterology Department, Jinhua Central Hospital, Jinhua, China Aims: Concerns have increased about the risk of fatal adverse events (FAEs) associated with molecular targeted agents (MTAs) in the treatment of advanced hepatocellular carcinoma (HCC). The purpose of this study is to investigate the overall incidence and risk of FAEs in advanced HCC with administration of MTAs by using a meta-analysis of available clinical trials.Materials and methods: Electronic databases were searched for relevant articles before March 2017. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Pooled incidence, Peto ORs and 95% CIs were calculated according to the heterogeneity of selected studies.Results: A total of 4,716 HCC participants from 10 randomized controlled trials (RCTs) were finally considered for this meta-analysis. The pooled incidence of death due to MTAs was 2.1% (95% CI 1.6%–2.8%) with a Peto OR of 1.79 (95% CI 1.07–3.01; p=0.027) in comparison with controlled groups. Subgroup analysis according to biological agents showed that brivanib treatment in HCC patients significantly increased the risk of developing FAEs (Peto OR 3.97; 95% CI 1.17–13.51; p=0.028) but not for sorafenib (Peto OR 1.78; 95% CI 0.54–5.89; p=0.34) and other MTAs (Peto OR 1.43; 95% CI 0.75–2.76; p=0.28). Sensitive analysis showed that the pooled results were influenced by removing each single trial. The most common causes of FAEs were hepatic failure (22.2%) and hemorrhage (13.3%), respectively.Conclusion: Clinicians should be aware of the risks of FAEs during the administration of MTAs in advanced HCC patients, especially for patients with abnormal liver function. However, the use of sorafenib remains justified in its approved indications due to their potential survival benefits and limited toxicities. Keywords: liver cancer, clinical trials, novel molecular agents

Published
2018

187. Large frequency range of negligible transmission in 1D photonic quantum well structures

Author

Zi, J., Wan, J., and Zhang, C.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We show that it is possible to enlarge the range of low transmission in 1D photonic crystals by using photonic quantum well structures. If a defect is introduced in the photonic quantum well structures, defect modes with a very high quality factor may appear. The transmission of the defect mode is due to the coupling between the eigenmodes of the defect and those at the band edges of the constituent photonic crystals., Comment: 3 pages, 3 figures, Revtex; submitted to Appl. Phys. Lett

Published
1998
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189. Influence of electron donor type and concentration on dynamics of bacterial populations associated with uranium reduction and remobilization

Author

Daly, R.M., Brodie, E.L., Kim, Y., Wan, J., Tokunaga, T.K., Andersen, G.L., Hazen, T.C., and Firestone, M.K.

Abstract

Background: Anthropogenic use of uranium has resulted in over 120 contaminated sites in the United States alone. Reductive precipitation of U(VI) by stimulating indigenous microorganisms dramatically decreases uranium solubility and is an attractive, low-cost bioremediation strategy. Our previous long-term sediment studies demonstrated that after an initial period of U(VI) reduction and immobilization significant reoxidation of U(IV) and remobilization of U(VI) occurred.

Published
2007

190. Design and construction of the near-earth space plasma simulation system of the Space Plasma Environment Research Facility.

Author

Ling, W., Jing, C., Wan, J., Mao, A., Xiao, Q., Guan, J., Cheng, J., Liu, C., and E, P.

Subjects
SPACE plasmas, MAGNETIC reconnection, SIMULATION methods & models, SPACE environment, SPACE exploration, MAGNETIC storms, STELLAR activity
Abstract

Our earth is immersed in the near-earth space plasma environment, which plays a vital role in protecting our planet against the solar-wind impact and influencing space activities. It is significant to investigate the physical processes dominating the environment, for deepening our scientific understanding of it and improving the ability to forecast the space weather. As a crucial part of the National Major Scientific and Technological Infrastructure–Space Environment Simulation Research Infrastructure (SESRI) in Harbin, the Space Plasma Environment Research Facility (SPERF) builds a system to replicate the near-earth space plasma environment in the laboratory. The system aims to simulate the three-dimensional (3-D) structure and processes of the terrestrial magnetosphere for the first time in the world, providing a unique platform to reveal the physics of the 3-D asymmetric magnetic reconnection relevant to the earth's magnetopause, wave–particle interaction in the earth's radiation belt, particles' dynamics during the geomagnetic storm, etc. The paper will present the engineering design and construction of the near-earth space plasma simulation system of the SPERF, with a focus on the critical technologies that have been resolved to achieve the scientific goals. Meanwhile, the possible physical issues that can be studied based on the apparatus are sketched briefly. The earth-based system is of great value in understanding the space plasma environment and supporting space exploration. [ABSTRACT FROM AUTHOR]

Published
2024
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199. Maximally Permissive Controlled System Synthesis for Modal Logic

Author

van Hulst, Alan C., Reniers, Michel A., Fokkink, Wan J., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Italiano, Giuseppe F., editor, Margaria-Steffen, Tiziana, editor, Pokorný, Jaroslav, editor, Quisquater, Jean-Jacques, editor, and Wattenhofer, Roger, editor

Published
2015
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