Search

Your search keyword '"Walker, Brian"' showing total 4,858 results
Start Over Author "Walker, Brian"

Refine your results

more »

more »

more »

more »

more »

more »
4,858 results on '"Walker, Brian"'

151. Rapid prototyping for quantifying belief weights of competing hypotheses about emergent diseases

Author

Robertson, Ellen P., primary, Walsh, Daniel P., additional, Martin, Julien, additional, Work, Thierry M., additional, Kellogg, Christina A., additional, Evans, James S., additional, Barker, Victoria, additional, Hawthorn, Aine, additional, Aeby, Greta, additional, Paul, Valerie J., additional, Walker, Brian K., additional, Kiryu, Yasunari, additional, Woodley, Cheryl M., additional, Meyer, Julie L., additional, Rosales, Stephanie M., additional, Studivan, Michael, additional, Moore, Jennifer F., additional, Brandt, Marilyn E., additional, and Bruckner, Andrew, additional

Published
2023
Full Text
View/download PDF

153. Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency

Author

Brossaud, Julie, primary, Bosch-Bouju, Clémentine, additional, Marissal-Arvy, Nathalie, additional, Campas-Lebecque, Marie-Neige, additional, Helbling, Jean-Christophe, additional, Webster, Scott P., additional, Walker, Brian R., additional, Fioramonti, Xavier, additional, Ferreira, Guillaume, additional, Barat, Pascal, additional, Corcuff, Jean-Benoît, additional, and Moisan, Marie-Pierre, additional

Published
2023
Full Text
View/download PDF

156. An evaluation of desktop video conferencing for one-to-one tutorial support in mathematics

Author

Walker, Brian Joseph

Subjects
510.715
Abstract

The growth in Flexible and Distributed Learning will, it is believed, lead to a need for a more innovative and flexible approach to the way support is offered to students. This study which was conducted with students at a Further Education College looks at the effectiveness of using Desktop Video Conferencing (DVC) to provide support to students studying mathematics at a number of different levels. The research design adopted the concept of triangulation with three different approaches being used. The first strand of the methodology was the collection of statistical data for all students re-sitting GCSE mathematics to develop a model to predict the learning outcome for students. The second strand was the extensive use of questionnaires and interviews with students receiving learning support. The final strand was the application of discourse analysis to recordings of both face-toface and DVe tutorials in order that a comparison could be made between them. To do this it was necessary to develop a research tool to record both verbal and non-verbal dialogue. The main conclusion from the study was that there was no identifiable difference in learning outcome between tutorials conducted face-to-face and those conducted using DVe. A number of positive advantages of using DVe emerged during the course of the study. These included the fact that most students preferred tutorials using DVC as they found the environment less threatening than when sitting next to a tutor. Other advantages resulted from the use of the electronic Whiteboard, these included being able to give students quicker feedback, if appropriate.

Published
2005

157. ENGINEERING ELECTROCONDUCTIVE AND ADHESIVE HYRDOGELS FOR BIOMEDICAL APPLICATIONS

Author

Walker, Brian Wayne

Subjects
Chemical engineering, Biomaterials, Nanomaterials, Regenerative Medicine, Tissue Engineering
Abstract

Bioadhesives, such as tissue sealants, hemostatic agents, and tissue sealants have gained increasing popularity for addressing wound management for traumatic and surgical injuries. This new generation of adhesive demonstrates significant advantages over traditional suturing and stapling techniques that can lead to infection, leakage of bodily fluid and gas, as well as secondary damage to tissues. Bioadhesives can be most broadly classified based on internal or external administration. While bioadhesives designed for external use are most widely used for topical application, such as wound closure, internal bioadhesives are surgically implanted and, therefore, require biocompatibility and strong adhesive ability to wet tissues. Further, hydrogel-based bioadhesives may be designed with nanoparticles or biopolymers that impart specific functionality, such as conductive or hemostatic properties. Scaffolds designed with conductive biomaterials have been extensively investigated in the field of tissue engineering based on their ability to support the function of excitable cell types, such as cardiomyocytes and neurons. Bioadhesives have also been designed to promote hemostasis for applications such as surgical sealants. In first two sections of this project, we aimed to develop conductive bioadhesives for cardiac tissue repair by combining highly biocompatible gelatin methacryloyl (GelMA), with an electrically conductive choline-based bio ionic liquid (Bio-IL). Here, we chemically modified gelatin to form photocrosslinkable hydrogels in the presence of visible or UV light, depending on the photoinitiator used. Conductive hydrogels were fabricated with varying concentrations of GelMA and Bio-IL, which resulted in scaffolds with high biocompatibility, as well as tunable electrical conductivity, and mechanical strength. We then demonstrated the ability of Bio-IL conjugated hydrogels to transduce physicochemical stimuli and modulate the growth of primary CMs in both 2D and 3D cultures in vitro. In addition, we demonstrated that the engineered hydrogels were highly biodegradable and biocompatible in vitro, and that they did not elicit inflammatory responses when implanted in vivo. Our following project investigated the development of cardiopatches using electrospun GelMA conjugated with Bio-IL. The resulting cardiopatches demonstrated tunable conductive and mechanical properties by optimizing the concentration of GelMA and Bio-IL used during synthesis. GelMA/Bio-IL cardiopatches exhibited excellent adhesiveness to cardiac tissues, and biocompatibility both in vitro and in vivo. CMs and CFs seeded on the surface of cardiopatches demonstrated excellent cell attachment and proliferation, and the scaffold supported the expression of gap junction proteins indicating the cells ability to function synchronously. Taken together, these conductive bioadhesives demonstrated excellent potential to be readily tailored to cardiac tissue regenerative therapies. Lastly, our group developed a hemostatic surgical sealant with robust mechanical properties based on the biopolymers GelMA and elastin-like polypeptide (ELP). These adhesive hydrogels were rendered hemostatic by the incorporation of the synthetic clay Laponite (LA) and were rapidly photocrosslinked in the presence of UV radiation using the photoinitiator Irgacure 2959. We demonstrated the highly tunable mechanical and adhesive properties of these nanocomposite hydrogels by varying the concentrations of GelMA and ELP. Likewise, we demonstrated the excellent hemostatic performance of these scaffolds both in vitro and in vivo by varying the concentration of LA. Our nanocomposite GelMA/ELP/LA hydrogels also showed remarkable biocompatibility both in vitro and in vivo and did not elicit an inflammatory response when implanted subcutaneously.

Published
2020

165. Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns

Author

Schinke, Carolina, Boyle, Eileen M., Ashby, Cody, Wang, Yan, Lyzogubov, Valeriy, Wardell, Christopher, Qu, Pingping, Hoering, Antje, Deshpande, Shayu, Ryan, Katie, Thanendrarajan, Sharmilan, Mohan, Meera, Yarlagadda, Naveen, Khan, Maliha, Choudhury, Samrat Roy, Zangari, Maurizio, van Rhee, Frits, Davies, Faith, Barlogie, Bart, Morgan, Gareth, and Walker, Brian A.

Published
2020
Full Text
View/download PDF

169. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Author

Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, and Tainer, John A.

Published
2019
Full Text
View/download PDF

170. Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Author

Went, Molly, Sud, Amit, Försti, Asta, Halvarsson, Britt-Marie, Weinhold, Niels, Kimber, Scott, van Duin, Mark, Thorleifsson, Gudmar, Holroyd, Amy, Johnson, David C., Li, Ni, Orlando, Giulia, Law, Philip J., Ali, Mina, Chen, Bowang, Mitchell, Jonathan S., Gudbjartsson, Daniel F., Kuiper, Rowan, Stephens, Owen W., Bertsch, Uta, Broderick, Peter, Campo, Chiara, Bandapalli, Obul R, Einsele, Hermann, Gregory, Walter A., Gullberg, Urban, Hillengass, Jens, Hoffmann, Per, Jackson, Graham H., Jöckel, Karl-Heinz, Johnsson, Ellinor, Kristinsson, Sigurður Y., Mellqvist, Ulf-Henrik, Nahi, Hareth, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, The PRACTICAL consortium, Nickel, Jolanta, Nöthen, Markus M., Rafnar, Thorunn, Ross, Fiona M., da Silva Filho, Miguel Inacio, Thomsen, Hauke, Turesson, Ingemar, Vangsted, Annette, Andersen, Niels Frost, Waage, Anders, Walker, Brian A., Wihlborg, Anna-Karin, Broyl, Annemiek, Davies, Faith E., Thorsteinsdottir, Unnur, Langer, Christian, Hansson, Markus, Goldschmidt, Hartmut, Kaiser, Martin, Sonneveld, Pieter, Stefansson, Kari, Morgan, Gareth J., Hemminki, Kari, Nilsson, Björn, and Houlston, Richard S.

Published
2019
Full Text
View/download PDF

174. Global Biodiversity Scenarios for the Year 2100

Author

Sala, Osvaldo E., Chapin, F. Stuart, Armesto, Juan J., Berlow, Eric, Bloomfield, Janine, Dirzo, Rodolfo, Huber-Sanwald, Elisabeth, Huenneke, Laura F., Jackson, Robert B., Kinzig, Ann, Leemans, Rik, Lodge, David M., Mooney, Harold A., Oesterheld, Martín, Poff, N. LeRoy, Sykes, Martin T., Walker, Brian H., Walker, Marilyn, and Wall, Diana H.

Published
2000

176. Contribution of local regeneration of glucocorticoids to tissue steroid pools

Author

Khan, Shazia, Livingstone, Dawn E. W, Zielinska, Agnieszka, Doig, Craig L, Cobice, Diego F, Esteves, Cristina L, Man, Janet Tak Yun, Homer, Natalie Z.M., Seckl, Jonathan R, Mackay, C.Logan, Webster, Scott P, Lavery, Gareth G, Chapman, Karen E, Walker, Brian R, and Andrew, Ruth

Abstract

11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) is a drug target to attenuate adverse effects of chronic glucocorticoid excess. It catalyses intracellular regeneration of active glucocorticoids in tissues including brain, liver and adipose tissue (coupled to hexose-6-phosphate dehydrogenase, H6PDH). 11βHSD1 activity in individual tissues is thought to contribute significantly to glucocorticoid levels at those sites, but its local contribution versus glucocorticoid delivery via the circulation is unknown. Here, we hypothesised that hepatic 11βHSD1 would contribute significantly to the circulating pool. This was studied in mice with Cre-mediated disruption of Hsd11b1 in liver (Alac-Cre) versus adipose tissue (aP2-Cre) or whole-body disruption of H6pdh. Regeneration of [9,12,12-2 46 H3]-cortisol (d3F) from [9,12,12-2 47 H3]-cortisone (d3E), measuring 11βHSD1 reductase activity was assessed at steady state following infusion of [9,11,12,12-2 48 H4]-cortisol (d4F) in male mice. Concentrations of steroids in plasma and amounts in liver, adipose tissue and brain were measured using mass spectrometry interfaced with matrix assisted laser desorption ionisation or liquid chromatography. Amounts of d3F were higher in liver, compared with brain and adipose tissue. Rates of appearance of d3F were ~6-fold slower in H6pdh-/- 52 mice, showing the importance of whole-body 11βHSD1 reductase activity. Disruption of liver 11βHSD1 reduced amounts of d3F in liver (by ~36%), without changes elsewhere. In contrast disruption of 11βHSD1 in adipose tissue reduced rates of appearance of circulating d3F (by ~67%) and also reduced regeneration of d3F in liver and brain (both by ~30%). Thus, the contribution of hepatic 11βHSD1 to circulating glucocorticoid levels and amounts in other tissues is less than that of adipose tissue.

Published
2023

179. Thinking DTG Ink: Here's what you need to know about your direct-to--garment printer's lifeblood

Author

Walker, Brian

Subjects
Inkjet printers, Printing inks, Clothing, Printing industry, Machinery, Ink jet printer, Business, Fashion, accessories and textiles industries, Sports, sporting goods and toys industry
Abstract

Direct-to-garment (DTG) printing has taken the industry by storm during the past several years. Technological advancements in both equipment and garments make this decorating process ideal for short-run printing and [...]

Published
2019

182. Kinase domain activation through gene rearrangement in multiple myeloma

Author

Morgan, Gareth J, He, Jie, Tytarenko, Ruslana, Patel, Purvi, Stephens, Owen W, Zhong, Shan, Deshpande, Shayu, Bauer, Michael, Weinhold, Niels, Schinke, Carolina, Rasche, Leo, Bailey, Mark, Ali, Siraj, Ross, Jeff, Miller, Vincent A, Stephens, Phillip, Thanendrarajan, Sharmilan, Zangari, Maurizio, van Rhee, Frits, Mughal, Tariq, Davies, Faith E, and Walker, Brian A

Published
2018
Full Text
View/download PDF

184. SUMMER '69

Author

Walker, Brian

Subjects
History, Military and naval science, Regional focus/area studies
Abstract

Apollo 11 propels astronauts Nell Armstrong, Michael Collins, and Edwin 'Buzz' Aldrin (above) to the moon--a staggering 953,054 miles from home. Cultural aftershocks are many and include David Bowie's 'Space [...]

Published
2023

187. Data from Perspectives on the Risk-Stratified Treatment of Multiple Myeloma

Author

Davies, Faith E., primary, Pawlyn, Charlotte, primary, Usmani, Saad Z., primary, San-Miguel, Jesus F., primary, Einsele, Hermann, primary, Boyle, Eileen M., primary, Corre, Jill, primary, Auclair, Daniel, primary, Cho, Hearn Jay, primary, Lonial, Sagar, primary, Sonneveld, Pieter, primary, Stewart, A. Keith, primary, Bergsagel, P. Leif, primary, Kaiser, Martin F., primary, Weisel, Katja, primary, Keats, Jonathan J., primary, Mikhael, Joseph R., primary, Morgan, Kathryn E., primary, Ghobrial, Irene M., primary, Orlowski, Robert Z., primary, Landgren, C. Ola, primary, Gay, Francesca, primary, Caers, Joseph, primary, Chng, Wee Joo, primary, Chari, Ajai, primary, Walker, Brian A., primary, Kumar, Shaji K., primary, Costa, Luciano J., primary, Anderson, Kenneth C., primary, and Morgan, Gareth J., primary

Published
2023
Full Text
View/download PDF

188. Supplementary Table from Perspectives on the Risk-Stratified Treatment of Multiple Myeloma

Author

Davies, Faith E., primary, Pawlyn, Charlotte, primary, Usmani, Saad Z., primary, San-Miguel, Jesus F., primary, Einsele, Hermann, primary, Boyle, Eileen M., primary, Corre, Jill, primary, Auclair, Daniel, primary, Cho, Hearn Jay, primary, Lonial, Sagar, primary, Sonneveld, Pieter, primary, Stewart, A. Keith, primary, Bergsagel, P. Leif, primary, Kaiser, Martin F., primary, Weisel, Katja, primary, Keats, Jonathan J., primary, Mikhael, Joseph R., primary, Morgan, Kathryn E., primary, Ghobrial, Irene M., primary, Orlowski, Robert Z., primary, Landgren, C. Ola, primary, Gay, Francesca, primary, Caers, Joseph, primary, Chng, Wee Joo, primary, Chari, Ajai, primary, Walker, Brian A., primary, Kumar, Shaji K., primary, Costa, Luciano J., primary, Anderson, Kenneth C., primary, and Morgan, Gareth J., primary

Published
2023
Full Text
View/download PDF

189. Abstract 3879: SETD2 is a novel and druggable dependency in IMiD/CELMoD resistant multiple myeloma models

Author

Bird, Sarah Anne, primary, Licciardello, Marco, additional, Chrisochoidou, Yakinthi, additional, Smith, James, additional, Barber, Amy, additional, Cheung, Jack, additional, Grabovska, Yura, additional, Martin, Shannon, additional, Sialana, Fernando, additional, Che, Harvey, additional, Bouguenina, Habib, additional, Bellenie, Benjamin, additional, Walker, Brian, additional, Clarke, Paul, additional, and Pawlyn, Charlotte, additional

Published
2023
Full Text
View/download PDF

190. Supplementary Data from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

192. Supplementary Table from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

194. Supplementary Figure from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

199. Supplementary Data from BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma

Author

Boyle, Eileen M., primary, Ashby, Cody, primary, Tytarenko, Ruslana G., primary, Deshpande, Shayu, primary, Wang, Hongwei, primary, Wang, Yan, primary, Rosenthal, Adam, primary, Sawyer, Jeffrey, primary, Tian, Erming, primary, Flynt, Erin, primary, Hoering, Antje, primary, Johnson, Sarah K., primary, Rutherford, Michael W., primary, Wardell, Christopher P., primary, Bauer, Michael A., primary, Dumontet, Charles, primary, Facon, Thierry, primary, Thanendrarajan, Sharmilan, primary, Schinke, Carolina D., primary, Zangari, Maurizio, primary, van Rhee, Frits, primary, Barlogie, Bart, primary, Cairns, David, primary, Jackson, Graham, primary, Thakurta, Anjan, primary, Davies, Faith E., primary, Morgan, Gareth J., primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results