151. The pandemic COVID-19: a tale of viremia, cellular oxidation and immune dysfunction.
- Author
-
Rowaiye AB, Onuh OA, Oli AN, Okpalefe OA, Oni S, and Nwankwo EJ
- Subjects
- Animals, Betacoronavirus immunology, COVID-19, Coronavirus Infections epidemiology, Coronavirus Infections immunology, Humans, Oxidation-Reduction, Pandemics, Pneumonia, Viral epidemiology, Pneumonia, Viral immunology, SARS-CoV-2, Viremia epidemiology, Viremia virology, Betacoronavirus pathogenicity, Coronavirus Infections virology, Immune System virology, Pneumonia, Viral virology
- Abstract
COVID-19, caused by SARS-CoV-2 is a tester of the immune system. While it spares the healthy, it brings severe morbidity and in a few cases, mortality to its victims. This article aims at critically reviewing the key virulence factors of COVID-19 which are the viremia, cellular oxidation and immune dysfunction. The averse economic effect of certain disease control measures such as national lock-downs and social distancing, though beneficial, makes them unsustainable. Worse still is the fact that wild animals and domestic pets are carriers of SARS-CoV-2 suggesting that the disease would take longer than expected to be eradicated globally. A better understanding of the pathological dynamics of COVID-19 would help the general populace to prepare for possible infection by the invisible enemy. While the world prospects for vaccines and therapeutic agents against the SARS-CoV-2, clinicians should also seek to modulate the immune system for optimum performance. Immunoprophylactic and immunomodulatory strategies are recommended for the different strata of stakeholders combating the pandemic with the hope that morbidities and mortalities associated with COVID-19 would be drastically reduced., Competing Interests: The authors declare no competing interests., (Copyright: Adekunle Babajide Rowaiye et al.)
- Published
- 2020
- Full Text
- View/download PDF