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151. Status report about COLLAPS experiments and output (period 2006-2008)

Author

Blaum, K, Yordanov, D, Neugart, R, Nörtershäuser, W, Schug, M, Krämer, J, Krieger, A, Neyens, G, Bissell, M, Vingerhoets, P, De Rydt, M, Ory, M, Lievens, P, Avgoulea, M, Flanagan, K, Geppert, C, Billowes, J, Cheal, B, Mané, E, Tungate, G, Forrest, D, Kowalska, M, and Stroke, H

Subjects
Detectors and Experimental Techniques
Published
2009

153. g factors of 17N and 18N remeasured

Author

De Rydt, M., Balabanski, D.L., Daugas, J.M., Himpe, P., Kameda, D., Lozeva, Radomira, Morel, Pierre, Perrot, L., Shimada, K., Stodel, C., Sugimoto, T., Thomas, J.C., Ueno, H., Vermeulen, N., Vingerhoets, P., Yoshimi, A., Neyens, G., Instituut voor Kern-en Stralingsfysica (IKS), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences (BAS), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), RIKEN Nishina Center for Accelerator-Based Science [Wako] (RIKEN RNC), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CYRIC, Tohoku University [Sendai], Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 21.10.Ky, 21.60.Cs, 24.70.+s, 27.20.+n
Abstract

Expérience GANIL, LISE; The g factors of the 17N and 18N ground states were remeasured using the β-nuclear magnetic resonance (β-NMR) technique on spin-polarized fragment beams at the LISE fragment separator at GANIL. Based on the g-factor results, the magnetic moments of 17N (I π = 1/2−) and 18N (I π = 1−) were deduced: |μ(17N)| = 0.3551(4) μN and |μ(18N)| = 0.3273(4) μN. Both results are in good agreement with and more precise than the earlier observed values.

Published
2009
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154. A new dedicated β-NMR/β-NQR setup for LISE-GANIL

Author

De Rydt, M., Lozeva, Radomira, Vermeulen, N., de Oliveira Santos, Francois, Grévy, S., Himpe, P., Stodel, C., Thomas, J.C., Vingerhoets, P., Neyens, G., Instituut voor Kern-en Stralingsfysica (IKS), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
β-Nuclear Magnetic Resonance(β-NMR), Nuclear moments, detection system, 21.10.Ky,27.20.+n,25.70.Mn,07.50.-e,07.55.-w,29.40.Mc,07.20.Mc, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], GEANT4, β-Nuclear Quadrupole Resonance(β-NQR)
Abstract

A new β-NMR/β-NQR setup is developed to study nuclear magnetic dipole moments and electric quadrupole moments at the LISE fragment separator at GANIL. Two key elements make the new design very powerful: the homogeneous magnet and the strong radio-frequency amplifier. The combination of both makes it possible to examine a broad spectrum of magnetic dipole and electric quadrupole moments. Several factors have an influence on the detection efficiency and on the sensitivity of the setup to observe a resonant change in the β-asymmetry: the thickness and the tilting angle of the implantation crystal, the material in the vacuum chamber, the applied magnetic field and the Qβ-value of the decaying nuclei. A detailed study of these effects is made using a dedicated GEANT4 Monte Carlo simulation code.

Published
2009
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155. Nuclear Spins and Magnetic Moments of 71,73,75Cu: Inversion of π2p3/2 and π1f5/2 Levels in 75Cu

Author

Flanagan, K T, Vingerhoets, P, Avgoulea. M, Billowes, J, Bissell, M L, Blaum, K, Cheal, B, De Rydt, M, Fedosseev, V N, Forest, D H, Geppert, Ch, Köster, U, Kowalska, M, Krämer, J, Kratz, K L, Krieger, A, Mané, E, Marsh, B A, Materna, T, Mathieu, L, Molkanov, P L, Neugart, R, Neyens, G, Nörtershäuser, W, Seliverstov, M D, Serot, O, Schug, M, Sjoedin, M A, Stone, J R, Stone, N J, Stroke, H H, Tungate, G, Yordanov, D T, and Volkov, Yu M

Subjects
Nuclear Physics - Experiment
Published
2009

157. An Observing Campaign of the Mutual Events Within (617) Patroclus-Menoetius Binary Trojan System

Author

Berthier, Jerôme, Marchis, Franck, Descamps, Pascal, Assafin, Marcelo, Bouley, Sylvain, Colas, François, Dubos, G., Emery, Joshua P., de Cat, Peter, Farrell, J. A., Leroy, A., Pauwels, Thierry, Pollock, Joseph T., Reddy, V., Sada, Pedro V., Vingerhoets, P., Vachier, Frédéric, Vieira Martins, Roberto, Wong, Michael H., Reichart, Daniel E., Ivarsen, Kevin M., Crain, J. A., Lacluyze, Aaron P., Nysewander, M. C., Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of California / SETI, Observatório do Valongo, Universidade Federal do Rio de Janeiro, Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, SETI Institute, Observatoire Royal de Belgique (ORB), Sulphur Flats Observatory, Appalachian State University, University of North Dakota, Universidad de Monterrey, Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Observatório Nacional/MCTI, UC Berkeley, University of North Carolina, and STScI

Subjects
[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

International audience; In 2006-2007, the binary Trojan system (617) Patroclus-Menotius reached one of its annual equinoxes. As a consequence, the system underwent a 6 months season of mutual eclipses and occultations. We organized a campaign of observations of these mutual events mostly centered along the first semester of 2007. We took advantage of an orbit solution of the similary-sized binary system published by Marchis et al. (Nature, 2006) to predict the timing of mutual eclipses and occultations observable from January to July 2007. During the campaign, the magnitude of Patroclus system varied from 15.8 to 16.6 and its solar phase from 9°.5 to 2°.7 at opposition (end of March). The amplitude of the events ranged between 0.2 and 0.3 magnitude. A large number of stations around the world were involved in the campaign and 20 lightcurves with mutual events signature were collected (http://www.imcce.fr/page.php?nav=en/observateur/campagnes_obs/patroclus/). With such favorable circumstances, photometric observations of the events will provide tight constraints regarding physical properties of the system such as sizes, shapes, sidereal spin period and surface composition. Combining AO observations collected at Keck and Gemini with this lightcurve data, we have refined the orbital parameters of the binary system to an unprecedented accuracy. We will present these findings, the determination of the sizes and shapes, and other results from the data analysis. This material is partly based upon work supported by the National Aeronautics and Space Administration issue through the Science Mission Directorate Research and Analysis Programs number NNG05GF09G.

Published
2007

159. The PHEMU09 catalogue and astrometric results of the observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made in 2009

Author

Arlot, J. -E., Emelyanov, N., Varfolomeev, M. I., Amossé, A., Arena, C., Assafin, M., Barbieri, L., Bolzoni, S., Bragas-Ribas, F., Camargo, J. I. B., Casarramona, F., Casas, R., Christou, A., Colas, F., Collard, A., Combe, S., Constantinescu, M., Dangl, G., De, Cat, P., Degenhardt, S., Delcroix, M., Dias-Oliveira, A., Dourneau, G., Douvris, A., Druon, C., Ellington, C. K., Estraviz, G., Farissier, P., Farmakopoulos, A., Garlitz, J., Gault, D., George, T., Gorda, S. Y., Grismore, J., Guo, D. F., Herald, D., Ida, M., Ishida, M., Ivanov, A. V., Klemt, B., Koshkin, N., Le, Campion, J. F., Liakos, A., Liao, S. L., Li, S. N., Loader, B., Lopresti, C., Lo, Savio, E., Marchini, A., Marino, G., Masi, G., Massallé, A., Maulella, R., Mcfarland, J., Miyashita, K., Napoli, C., Noyelles, B., Pauwels, T., Pavlov, H., Peng, Q. Y., Perelló, C., Priban, V., Prost, J., Razemon, S., Rousselle, J. P., Rovira, J., Ruisi, R., Ruocco, N., Salvaggio, F., Sbarufatti, G., Shakun, L., Scheck, A., Sciuto, C., Da, Silva, Neto, D. N., V, Sinyaeva, N., Sofia, A., Sonka, A., Talbot, J., Tang, Z. H., Tejfel, V. G., Thuillot, W., Tigani, K., Timerson, B., Tontodonati, E., Tsamis, V., Unwin, M., Venable, R., Vieira-Martins, R., Vilar, J., Vingerhoets, P., Watanabe, H., Yin, H. X., Yu, Y., Zambelli, R., Arlot, J. -E., Emelyanov, N., Varfolomeev, M. I., Amossé, A., Arena, C., Assafin, M., Barbieri, L., Bolzoni, S., Bragas-Ribas, F., Camargo, J. I. B., Casarramona, F., Casas, R., Christou, A., Colas, F., Collard, A., Combe, S., Constantinescu, M., Dangl, G., De, Cat, P., Degenhardt, S., Delcroix, M., Dias-Oliveira, A., Dourneau, G., Douvris, A., Druon, C., Ellington, C. K., Estraviz, G., Farissier, P., Farmakopoulos, A., Garlitz, J., Gault, D., George, T., Gorda, S. Y., Grismore, J., Guo, D. F., Herald, D., Ida, M., Ishida, M., Ivanov, A. V., Klemt, B., Koshkin, N., Le, Campion, J. F., Liakos, A., Liao, S. L., Li, S. N., Loader, B., Lopresti, C., Lo, Savio, E., Marchini, A., Marino, G., Masi, G., Massallé, A., Maulella, R., Mcfarland, J., Miyashita, K., Napoli, C., Noyelles, B., Pauwels, T., Pavlov, H., Peng, Q. Y., Perelló, C., Priban, V., Prost, J., Razemon, S., Rousselle, J. P., Rovira, J., Ruisi, R., Ruocco, N., Salvaggio, F., Sbarufatti, G., Shakun, L., Scheck, A., Sciuto, C., Da, Silva, Neto, D. N., V, Sinyaeva, N., Sofia, A., Sonka, A., Talbot, J., Tang, Z. H., Tejfel, V. G., Thuillot, W., Tigani, K., Timerson, B., Tontodonati, E., Tsamis, V., Unwin, M., Venable, R., Vieira-Martins, R., Vilar, J., Vingerhoets, P., Watanabe, H., Yin, H. X., Yu, Y., and Zambelli, R.

Abstract

Context. In 2009, the Sun and the Earth passed through the equatorial plane of Jupiter and therefore the orbital planes of its main satellites. It was the equinox on Jupiter. This occurrence made mutual occultations and eclipses between the satellites possible. Experience has shown that the observations of such events provide accurate astrometric data able to bring new information on the dynamics of the Galilean satellites. Observations are made under the form of photometric measurements, but need to be made through the organization of a worldwide observation campaign maximizing the number and the quality of the data obtained. Aims. This work focuses on processing the complete database of photometric observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made during the international campaign in 2009. The final goal is to derive new accurate astrometric data. Methods. We used an accurate photometric model of mutual events adequate with the accuracy of the observation. Our original method was applied to derive astrometric data from photometric observations of mutual occultations and eclipses of the Galilean satellites of Jupiter. Results. We processed the 457 lightcurves obtained during the international campaign of photometric observations of the Galilean satellites of Jupiter in 2009. Compared with the theory, for successful observations, the r.m.s. of O-C residuals are equal to 45.8 mas and 81.1 mas in right ascension and declination, respectively; the mean O-C residuals are equal to -2 mas and -9 mas in right ascension and declination, respectively, for mutual occultations; and -6 mas and +1 mas in right ascension and declination, respectively, for mutual eclipses. © ESO, 2014.

Published
2014

160. The PHEMU09 catalogue and astrometric results of the observations of the mutual occultations and eclipses of the Galilean satellites of Jupiter made in 2009

Author

Arlot, J.-E., primary, Emelyanov, N., additional, Varfolomeev, M. I., additional, Amossé, A., additional, Arena, C., additional, Assafin, M., additional, Barbieri, L., additional, Bolzoni, S., additional, Bragas-Ribas, F., additional, Camargo, J. I. B., additional, Casarramona, F., additional, Casas, R., additional, Christou, A., additional, Colas, F., additional, Collard, A., additional, Combe, S., additional, Constantinescu, M., additional, Dangl, G., additional, De Cat, P., additional, Degenhardt, S., additional, Delcroix, M., additional, Dias-Oliveira, A., additional, Dourneau, G., additional, Douvris, A., additional, Druon, C., additional, Ellington, C. K., additional, Estraviz, G., additional, Farissier, P., additional, Farmakopoulos, A., additional, Garlitz, J., additional, Gault, D., additional, George, T., additional, Gorda, S. Yu., additional, Grismore, J., additional, Guo, D. F., additional, Herald, D., additional, Ida, M., additional, Ishida, M., additional, Ivanov, A. V., additional, Klemt, B., additional, Koshkin, N., additional, Le Campion, J. F., additional, Liakos, A., additional, Liao, S. L., additional, Li, S. N., additional, Loader, B., additional, Lopresti, C., additional, Lo Savio, E., additional, Marchini, A., additional, Marino, G., additional, Masi, G., additional, Massallé, A., additional, Maulella, R., additional, McFarland, J., additional, Miyashita, K., additional, Napoli, C., additional, Noyelles, B., additional, Pauwels, T., additional, Pavlov, H., additional, Peng, Q. Y., additional, Perelló, C., additional, Priban, V., additional, Prost, J., additional, Razemon, S., additional, Rousselle, J. P., additional, Rovira, J., additional, Ruisi, R., additional, Ruocco, N., additional, Salvaggio, F., additional, Sbarufatti, G., additional, Shakun, L., additional, Scheck, A., additional, Sciuto, C., additional, da Silva Neto, D. N., additional, V Sinyaeva, N., additional, Sofia, A., additional, Sonka, A., additional, Talbot, J., additional, Tang, Z. H., additional, Tejfel, V. G., additional, Thuillot, W., additional, Tigani, K., additional, Timerson, B., additional, Tontodonati, E., additional, Tsamis, V., additional, Unwin, M., additional, Venable, R., additional, Vieira-Martins, R., additional, Vilar, J., additional, Vingerhoets, P., additional, Watanabe, H., additional, Yin, H. X., additional, Yu, Y., additional, and Zambelli, R., additional

Published
2014
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161. Social and psychological consequences of not crying: possible associations with psychopathology and therapeutic relevance

Author

Hesdorffer, Dale C., Vingerhoets, Ad J.J.M., and Trimble, Michael R.

Abstract

ObjectiveEmotional crying is hypothesized to serve intra- and interpersonal functions. Intrapersonal functions are assumed to facilitate the capacity to recover from emotional distress, thus promoting well-being. Interpersonal functions are postulated to have a major impact on social functioning. We hypothesized that non-criers would have lower well-being and poorer social functioning than criers.MethodsStudy participants included 475 people who reportedly lost the capacity to cry and 179 “normal” control criers. Applied measures assessed crying, well-being, empathy, attachment, social support, and connection with others. Prevalence estimates of not crying by gender were obtained from a panel survey of 2,000 Dutch households.ResultsIn the main survey, tearless cases had less connection with others, less empathy, and experienced less social support, but were equal in terms of well-being. They also reported being less moved by emotional stimuli and had a more avoidant and less anxious attachment style. In multivariate analyses, being male, having an avoidant attachment style, and lacking empathy were independent predictors of tearlessness. Some 46.1% felt that not being able to cry affected them negatively; however, despite these findings, only 2.9% had sought any kind of professional help. Loss of the capacity to cry occurred in 8.6% of the men and 6.5% of the women in the large panel survey.ConclusionsDespite reduced empathy, less connection with others, and a more avoidant/less anxious attachment type, well-being is maintained in tearless people. Additional clinical and therapeutic investigations of tearlessness may lead to clarification of bidirectional associations between psychiatric disorders (e.g., alexithymia, posttraumatic stress disorder, psychopathy) and tearlessness.

Published
2018
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162. Atypical brain functional segregation is more frequent in situs inversus totalis

Author

Vingerhoets, Guy, Gerrits, Robin, and Bogaert, Stephanie

Abstract

Most humans show typical brain functional specialization with language and praxis favoring left hemisphere lateralization and spatial attention and face recognition showing right hemisphere dominance. Lateralization of these cognitive functions was investigated using fMRI in participants with complete visceral reversal and matched control participants. While most participants revealed typical brain organization, atypical functional segregation was significantly more frequent in participants with visceral reversal. Interestingly, some left handers maintained typical functional segregation but showed complete reversal of all cognitive functions regardless of visceral organization. Cognitive performance, as measured with a neuropsychological test battery, was significantly predicted by the degree of atypical functional segregation of praxis and spatial attention. Increased deviation from typical functional segregation paired with lower cognitive performance. The findings suggest that typical functional segregation reflects an optimal evolutionary solution with deviations being associated with reduced cognitive performance.

Published
2018
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163. Are tearful individuals perceived as less competent? Probably not

Author

Zickfeld, Janis H., van de Ven, Niels, Schubert, Thomas W., and Vingerhoets, Ad

Abstract

ABSTRACTWhat are the social signals of emotional tears? This question has fascinated scholars ever since Darwin. Studies have suggested several interpersonal effects of emotional tears. A recent article presented evidence in three studies that tearful individuals are not only perceived as warmer but also less competent than their non-tearful counterparts. However, the competence effect was relatively small, and a recent replication failed to find such an effect in two different populations while the warmth effect was replicated. This questions the generalizability of the effect of tears on perceived competence. To test whether individuals expressing emotional tears are really perceived as less competent and what boundary conditions such an effect might have, we specified a decision tree of three different studies in which we test differences between the original reference study and the replication. We replicated previous findings of the perceived (in)competence in Study 1 (n = 531) but observed a considerably smaller nonsignificant effect when proceeding to Study 2 (n = 471), which increased the number of stimuli. The earlier and now repeated replication failure can therefore likely be attributed to an increased variation in stimulus material. We conclude that there is not enough evidence to argue that one social outcome of tears signals a relative lack of competence as the effect seems to depend on the specific stimuli used.

Published
2018
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164. Pimodivir Treatment in Adult Volunteers Experimentally Inoculated with Live Influenza Virus: A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study

Author

Trevejo, Jose M, Asmal, Mohammed, Vingerhoets, Johan, Polo, Ramon, Robertson, Sarah, Jiang, Ying, Kieffer, Tara L, and Leopold, Lorant

Abstract

Background Pimodivir (formerly JNJ-63623872) is a novel, non-nucleoside polymerase complex inhibitor with in vitroactivity against influenza A virus, including pandemic 2009 H1N1, H7N9, H5N1 strains as well as neuraminidase- and amantadine-resistant strains.Methods Randomized, double-blind, placebo-controlled, Phase IIa study. Healthy volunteers (n=104) were inoculated with an influenza A/Wisconsin/67/2005 (H3N2) challenge virus. 72 received pimodivir and 32 placebo. Pimodivir was dosed for 5 days once daily from 24 h after viral inoculation at four dose levels: 100 mg, 400 mg, loading dose 900/600 mg and loading dose 1,200/600 mg.Results Pimodivir significantly reduced viral shedding (area under the concentration versus time curve [AUC] measured by 50% tissue culture infective dose [TCID50] or qRT-PCR) versus placebo as measured by cell culture assay in the pooled analysis (Jonckheere-Terpstra dose-response trend test [P=0.036]). Reductions were observed in viral shedding (AUC, duration and peak measured by grade), influenza-like symptoms (AUC, duration and peak measured by grade) and clinical symptoms (duration and peak measured by grade) for all pimodivir groups versus placebo, significantly so for the 1,200/600 mg group. In the 1,200/600 mg group viral shedding (AUC) by qRT-PCR was 0.45 versus 18.4 log10copies/ml*day for pooled placebo (P=0.014). Pimodivir was generally safe and well-tolerated with no serious adverse events or adverse events leading to discontinuation.Conclusions Pimodivir has potential to not only reduce viral load but to have a clinical impact on patients as a novel treatment for influenza A virus infection. Further trials are therefore warranted to assess pimodivir.

Published
2018
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165. Nuclear Spins and Magnetic Moments of Cu-71,Cu-73,Cu-75 : Inversion of pi 2p(3/2) and pi 1f(5/2) Levels in Cu-75

Author

Flanagan, K. T., Vingerhoets, P., Avgoulea, M., Billowes, J., Bissell, M. L., Blaum, K., Cheal, B., De Rydt, M., Fedosseev, V. N., Forest, D. H., Geppert, Ch., Koester, U., Kowalska, M., Kraemer, J., Kratz, K. L., Krieger, A., Mane, E., Marsh, B. A., Materna, T., Mathieu, L., Molkanov, P. L., Neugart, R., Neyens, G., Noertershaeuser, W., Seliverstov, M. D., Serot, O., Schug, M., Sjödin, Mikael, Stone, J. R., Stone, N. J., Stroke, H. H., Tungate, G., Yordanov, D. T., Volkov, Yu. M., Flanagan, K. T., Vingerhoets, P., Avgoulea, M., Billowes, J., Bissell, M. L., Blaum, K., Cheal, B., De Rydt, M., Fedosseev, V. N., Forest, D. H., Geppert, Ch., Koester, U., Kowalska, M., Kraemer, J., Kratz, K. L., Krieger, A., Mane, E., Marsh, B. A., Materna, T., Mathieu, L., Molkanov, P. L., Neugart, R., Neyens, G., Noertershaeuser, W., Seliverstov, M. D., Serot, O., Schug, M., Sjödin, Mikael, Stone, J. R., Stone, N. J., Stroke, H. H., Tungate, G., Yordanov, D. T., and Volkov, Yu. M.

Abstract

We report the first confirmation of the predicted inversion between the pi 2p(3/2) and pi 1f(5/2) nuclear states in the nu g(9/2) midshell. This was achieved at the ISOLDE facility, by using a combination of in-source laser spectroscopy and collinear laser spectroscopy on the ground states of Cu-71,Cu-73,Cu-75, which measured the nuclear spin and magnetic moments. The obtained values are mu(Cu-71)=+2.2747(8)mu(N), mu(Cu-73)=+1.7426(8)mu(N), and mu(Cu-75)=+1.0062(13)mu(N) corresponding to spins I=3/2 for Cu-71,Cu-73 and I=5/2 for Cu-75. The results are in fair agreement with large-scale shell-model calculations., QC 20110411

Published
2009
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166. The PHEMU03 catalogue of observations of the mutual phenomena of the Galilean satellites of Jupiter

Author

Arlot, J. -E., Thuillot, W., Ruatti, C., Ahmad, A., Amosse, A., Anbazhagan, P., Andreyev, M., Antov, A., Appakutty, M., Asher, D., Aubry, S., Baron, N., Bassiere, N., Berthe, M., Bogdanovski, R., Bosq, F., Bredner, E., Buettner, D., Buromsky, M., Cammarata, S., Casas, R., Chis, G. D., Christou, A. A., Coquerel, J. -P., Corlan, R., Cremaschini, C., Crussaire, D., Cuypers, J., Dennefeld, M., Descamps, P., Devyatkin, A., Dimitrov, D., Dorokhova, T. N., Dorokhov, N. I., Dourneau, G., Duenas, M., Dumitrescu, A., Emelianov, N., Ferrara, D., Fiel, D., Fienga, A., Flatres, T., Foglia, S., Garlitz, J., Gerbos, J., Gilbert, R., Goncalves, R. M. D., Gonzales, D., Gorda, S. Yu., Gorshanov, D. L., Hansen, M. W., Harrington, M., Irsmambetova, T. R., Ito, Y., Ivanova, V., Izmailov, I. S., Khovritchev, M. Yu., Khrutskaya, E. V., Kieken, J., Kiseleva, T. P., Kuppuswamy, K., Lainey, V., Lavayssiere, M., Lazzarotti, P., Le Campion, J. -F., Lellouch, E., Li, Z. L., Lo Savio, E., Lou, M., Magny, E., Manek, J., Marinello, W., Marino, G., McAuliffe, J. P., Michelli, M., Moldovan, D., Montagnac, S., Moorthy, V., Nickel, O., Nier, J. M., Noel, T., Noyelles, B., Oksanen, A., Parrat, D., Pauwels, T., Peng, Q. Y., Pizzetti, G., Priban, V., Ramachandran, B., Rambaux, N., Rapaport, M., Rapavy, P., Rau, G., Sacre, J. -J., Sada, P. V., Salvaggio, F., Sarlin, P., Sciuto, C., Selvakumar, G., Sergeyev, A., Sidorov, M., Sorescu, S., Spampinato, S. A., Stellmacher, I., Trunkovsky, E., Tejfel, V., Tudose, V., Turcu, V., Ugarte, I., Vantyghem, P., Vasundhara, R., Vaubaillon, J., Velu, C., Venkataramana, A. K., Vidal-Sainz, J., Vienne, A., Vilar, J., Vingerhoets, P., Vollman, W., Arlot, J. -E., Thuillot, W., Ruatti, C., Ahmad, A., Amosse, A., Anbazhagan, P., Andreyev, M., Antov, A., Appakutty, M., Asher, D., Aubry, S., Baron, N., Bassiere, N., Berthe, M., Bogdanovski, R., Bosq, F., Bredner, E., Buettner, D., Buromsky, M., Cammarata, S., Casas, R., Chis, G. D., Christou, A. A., Coquerel, J. -P., Corlan, R., Cremaschini, C., Crussaire, D., Cuypers, J., Dennefeld, M., Descamps, P., Devyatkin, A., Dimitrov, D., Dorokhova, T. N., Dorokhov, N. I., Dourneau, G., Duenas, M., Dumitrescu, A., Emelianov, N., Ferrara, D., Fiel, D., Fienga, A., Flatres, T., Foglia, S., Garlitz, J., Gerbos, J., Gilbert, R., Goncalves, R. M. D., Gonzales, D., Gorda, S. Yu., Gorshanov, D. L., Hansen, M. W., Harrington, M., Irsmambetova, T. R., Ito, Y., Ivanova, V., Izmailov, I. S., Khovritchev, M. Yu., Khrutskaya, E. V., Kieken, J., Kiseleva, T. P., Kuppuswamy, K., Lainey, V., Lavayssiere, M., Lazzarotti, P., Le Campion, J. -F., Lellouch, E., Li, Z. L., Lo Savio, E., Lou, M., Magny, E., Manek, J., Marinello, W., Marino, G., McAuliffe, J. P., Michelli, M., Moldovan, D., Montagnac, S., Moorthy, V., Nickel, O., Nier, J. M., Noel, T., Noyelles, B., Oksanen, A., Parrat, D., Pauwels, T., Peng, Q. Y., Pizzetti, G., Priban, V., Ramachandran, B., Rambaux, N., Rapaport, M., Rapavy, P., Rau, G., Sacre, J. -J., Sada, P. V., Salvaggio, F., Sarlin, P., Sciuto, C., Selvakumar, G., Sergeyev, A., Sidorov, M., Sorescu, S., Spampinato, S. A., Stellmacher, I., Trunkovsky, E., Tejfel, V., Tudose, V., Turcu, V., Ugarte, I., Vantyghem, P., Vasundhara, R., Vaubaillon, J., Velu, C., Venkataramana, A. K., Vidal-Sainz, J., Vienne, A., Vilar, J., Vingerhoets, P., and Vollman, W.

Published
2009

175. Nuclear mean-square charge radii of63,64,66,68−82Ga nuclei: No anomalous behavior atN=32

Author

Procter, T. J., primary, Billowes, J., additional, Bissell, M. L., additional, Blaum, K., additional, Charlwood, F. C., additional, Cheal, B., additional, Flanagan, K. T., additional, Forest, D. H., additional, Fritzsche, S., additional, Geppert, Ch., additional, Heylen, H., additional, Kowalska, M., additional, Kreim, K., additional, Krieger, A., additional, Krämer, J., additional, Lynch, K. M., additional, Mané, E., additional, Moore, I. D., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Papuga, J., additional, Rajabali, M. M., additional, Stroke, H. H., additional, Vingerhoets, P., additional, Yordanov, D. T., additional, and Žáková, M., additional

Published
2012
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176. Laser spectroscopy of gallium isotopes beyondN= 50

Author

Cheal, B, primary, Billowes, J, additional, Bissell, M L, additional, Blaum, K, additional, Charlwood, F C, additional, Flanagan, K T, additional, Forest, D H, additional, Geppert, Ch, additional, Kowalska, M, additional, Kreim, K, additional, Krieger, A, additional, Krämer, J, additional, Lynch, K M, additional, Mané, E, additional, Moore, I D, additional, Neugart, R, additional, Neyens, G, additional, Nörtershäuser, W, additional, Papuga, J, additional, Procter, T J, additional, Rajabali, M M, additional, Stroke, H H, additional, Vingerhoets, P, additional, Yordanov, D T, additional, and Žáková, M, additional

Published
2012
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177. Nuclear Charge Radii ofMg21−32

Author

Yordanov, D. T., primary, Bissell, M. L., additional, Blaum, K., additional, De Rydt, M., additional, Geppert, Ch., additional, Kowalska, M., additional, Krämer, J., additional, Kreim, K., additional, Krieger, A., additional, Lievens, P., additional, Neff, T., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Sánchez, R., additional, and Vingerhoets, P., additional

Published
2012
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178. Existential Well-Being

Author

Visser, Anja, Garssen, Bert, and Vingerhoets, Ad JJM

Abstract

Measures of spirituality often contain the dimension existential well-being (EWB). However, EWB has been found to overlap with emotional and psychological well-being. Using the Spiritual Attitude and Involvement List (SAIL), we have further investigated the overlap between aspects of spirituality and of well-being among patients with cancer, by determining a) the divergent validity of the subscales of the SAIL compared with a well-being questionnaire and b) the differences in their associations to changes in pain and fatigue, and the occurrence of negative life events. Our findings suggest that a sense of trust that one is able to cope with difficulties of life belongs to the realm of well-being, instead of spirituality. Other aspects, such as a sense of meaning in life, seem more similar to spirituality than to well-being. These results can bring researchers a step further toward constructing “pure” spirituality and well-being measures, which will allow them to investigate the (causal) relationship between these constructs.

Published
2017
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179. Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study

Author

Vingerhoets, Johan, Van Dromme, Ilse, van Duijnhoven, Wilbert, Anderson, David, De Meyer, Sandra, and Leopold, Lorant

Abstract

Background Pimodivir is a first-in-class polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A polymerase complex. The randomized double-blinded placebo-controlled phase 2b TOPAZ study demonstrated antiviral activity and safety of twice daily pimodivir alone (300 mg, 600 mg) or in combination with oseltamivir (pimodivir 600 mg, oseltamivir 75 mg) in adult study participants with acute uncomplicated influenza A. The detailed genotypic and phenotypic characterization of viral variants observed in this study are reported.Methods Population sequencing of PB2 and neuraminidase genes, and phenotypic susceptibility testing, were performed using baseline and last virus-positive post-baseline nasal swab samples.Results Sequencing of baseline samples in 206 of 223 (92.4%) randomized study participants with confirmed influenza A infection identified no polymorphisms at any predefined PB2 positions of interest for pimodivir and no phenotypic reduced susceptibility to pimodivir was observed. Post-baseline sequencing data for 105/223 (47.1%) participants identified emergence of PB2 mutations at amino acid positions of interest in 10 (9.5%) participants (pimodivir 300 mg: n= 3; 600 mg: n= 6; combination: n= 1; placebo: n= 0) and included positions S324, F325, S337, K376, T378, and N510. These emerging mutations were typically associated with decreased pimodivir susceptibility, but not viral breakthrough. No reduced phenotypic susceptibility was observed in the one (1.8%) participant with emerging PB2 mutations from the pimodivir plus oseltamivir group.Conclusions Participants with acute uncomplicated influenza A treated with pimodivir in the TOPAZ study infrequently developed reduced susceptibility to pimodivir and combining pimodivir with oseltamivir further decreased the risk of reduced susceptibility development.

Published
2023
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180. Magnetic and quadrupole moments of neutron deficient 58–62Cu isotopes

Author

Vingerhoets, P., primary, Flanagan, K.T., additional, Billowes, J., additional, Bissell, M.L., additional, Blaum, K., additional, Cheal, B., additional, De Rydt, M., additional, Forest, D.H., additional, Geppert, Ch., additional, Honma, M., additional, Kowalska, M., additional, Krämer, J., additional, Kreim, K., additional, Krieger, A., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Papuga, J., additional, Procter, T.J., additional, Rajabali, M.M., additional, Sánchez, R., additional, Stroke, H.H., additional, and Yordanov, D.T., additional

Published
2011
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181. Ground-state spins and moments of72,74,76,78Ga nuclei

Author

Mané, E., primary, Cheal, B., additional, Billowes, J., additional, Bissell, M. L., additional, Blaum, K., additional, Charlwood, F. C., additional, Flanagan, K. T., additional, Forest, D. H., additional, Geppert, Ch., additional, Kowalska, M., additional, Krieger, A., additional, Krämer, J., additional, Moore, I. D., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Rajabali, M. M., additional, Sánchez, R., additional, Schug, M., additional, Stroke, H. H., additional, Vingerhoets, P., additional, Yordanov, D. T., additional, and Žáková, M., additional

Published
2011
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182. Nuclear spins, magnetic moments, and quadrupole moments of Cu isotopes fromN=28toN=46: Probes for core polarization effects

Author

Vingerhoets, P., primary, Flanagan, K. T., additional, Avgoulea, M., additional, Billowes, J., additional, Bissell, M. L., additional, Blaum, K., additional, Brown, B. A., additional, Cheal, B., additional, De Rydt, M., additional, Forest, D. H., additional, Geppert, Ch., additional, Honma, M., additional, Kowalska, M., additional, Krämer, J., additional, Krieger, A., additional, Mané, E., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Otsuka, T., additional, Schug, M., additional, Stroke, H. H., additional, Tungate, G., additional, and Yordanov, D. T., additional

Published
2010
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183. Discovery of a long-lived low-lying isomeric state inGa80

Author

Cheal, B., primary, Billowes, J., additional, Bissell, M. L., additional, Blaum, K., additional, Charlwood, F. C., additional, Flanagan, K. T., additional, Forest, D. H., additional, Fritzsche, S., additional, Geppert, Ch., additional, Jokinen, A., additional, Kowalska, M., additional, Krieger, A., additional, Krämer, J., additional, Mané, E., additional, Moore, I. D., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Rajabali, M. M., additional, Schug, M., additional, Stroke, H. H., additional, Vingerhoets, P., additional, Yordanov, D. T., additional, and Žáková, M., additional

Published
2010
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184. Experimental determination of anIπ=2−ground state inCu72,74

Author

Flanagan, K. T., primary, Vingerhoets, P., additional, Bissell, M. L., additional, Blaum, K., additional, Brown, B. A., additional, Cheal, B., additional, De Rydt, M., additional, Forest, D. H., additional, Geppert, Ch., additional, Honma, M., additional, Kowalska, M., additional, Krämer, J., additional, Krieger, A., additional, Mané, E., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Schug, M., additional, Stroke, H. H., additional, and Yordanov, D. T., additional

Published
2010
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185. Publisher’s Note:gfactor of theCl44ground state: Probing the reducedZ=16andN=28gaps [Phys. Rev. C81, 034308 (2010)]

Author

De Rydt, M., primary, Daugas, J. M., additional, de Oliveira Santos, F., additional, Gaudefroy, L., additional, Grévy, S., additional, Kameda, D., additional, Kumar, V., additional, Lozeva, R., additional, Mertzimekis, T. J., additional, Morel, P., additional, Nagatomo, T., additional, Neyens, G., additional, Perrot, L., additional, Sorlin, O., additional, Stödel, C., additional, Thomas, J. C., additional, Vermeulen, N., additional, and Vingerhoets, P., additional

Published
2010
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186. gfactor of theCl44ground state: Probing the reducedZ=16andN=28gaps

Author

De Rydt, M., primary, Daugas, J. M., additional, de Oliveira Santos, F., additional, Gaudefroy, L., additional, Grévy, S., additional, Kameda, D., additional, Kumar, V., additional, Lozeva, R., additional, Mertzimekis, T. J., additional, Morel, P., additional, Nagatomo, T., additional, Neyens, G., additional, Perrot, L., additional, Sorlin, O., additional, Stödel, C., additional, Thomas, J. C., additional, Vermeulen, N., additional, and Vingerhoets, P., additional

Published
2010
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187. A new dedicated setup for LISE-GANIL

Author

De Rydt, M., primary, Lozeva, R., additional, Vermeulen, N., additional, de Oliveira Santos, F., additional, Grévy, S., additional, Himpe, P., additional, Stödel, C., additional, Thomas, J.C., additional, Vingerhoets, P., additional, and Neyens, G., additional

Published
2009
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188. Nuclear Spins and Magnetic Moments ofCu71,73,75: Inversion ofπ2p3/2andπ1f5/2Levels inCu75

Author

Flanagan, K. T., primary, Vingerhoets, P., additional, Avgoulea, M., additional, Billowes, J., additional, Bissell, M. L., additional, Blaum, K., additional, Cheal, B., additional, De Rydt, M., additional, Fedosseev, V. N., additional, Forest, D. H., additional, Geppert, Ch., additional, Köster, U., additional, Kowalska, M., additional, Krämer, J., additional, Kratz, K. L., additional, Krieger, A., additional, Mané, E., additional, Marsh, B. A., additional, Materna, T., additional, Mathieu, L., additional, Molkanov, P. L., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Seliverstov, M. D., additional, Serot, O., additional, Schug, M., additional, Sjoedin, M. A., additional, Stone, J. R., additional, Stone, N. J., additional, Stroke, H. H., additional, Tungate, G., additional, Yordanov, D. T., additional, and Volkov, Yu. M., additional

Published
2009
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189. gfactors ofN17andN18remeasured

Author

Rydt, M. De, primary, Balabanski, D. L., additional, Daugas, J. M., additional, Himpe, P., additional, Kameda, D., additional, Lozeva, R., additional, Morel, P., additional, Perrot, L., additional, Shimada, K., additional, Stödel, C., additional, Sugimoto, T., additional, Thomas, J. C., additional, Ueno, H., additional, Vermeulen, N., additional, Vingerhoets, P., additional, Yoshimi, A., additional, and Neyens, G., additional

Published
2009
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190. Nuclear ground-state spin and magnetic moment of 21Mg

Author

Krämer, J., primary, Blaum, K., additional, De Rydt, M., additional, Flanagan, K.T., additional, Geppert, Ch., additional, Kowalska, M., additional, Lievens, P., additional, Neugart, R., additional, Neyens, G., additional, Nörtershäuser, W., additional, Stroke, H.H., additional, Vingerhoets, P., additional, and Yordanov, D.T., additional

Published
2009
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191. Precision measurement of the electric quadrupole moment of 31Al and determination of the effective proton charge in the sd-shell

Author

De Rydt, M., primary, Neyens, G., additional, Asahi, K., additional, Balabanski, D.L., additional, Daugas, J.M., additional, Depuydt, M., additional, Gaudefroy, L., additional, Grévy, S., additional, Hasama, Y., additional, Ichikawa, Y., additional, Morel, P., additional, Nagatomo, T., additional, Otsuka, T., additional, Perrot, L., additional, Shimada, K., additional, Stödel, C., additional, Thomas, J.C., additional, Ueno, H., additional, Utsuno, Y., additional, Vanderheijden, W., additional, Vermeulen, N., additional, Vingerhoets, P., additional, and Yoshimi, A., additional

Published
2009
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192. The PHEMU03 catalogue of observations of the mutual phenomena of the Galilean satellites of Jupiter

Author

Arlot, J.-E., primary, Thuillot, W., additional, Ruatti, C., additional, Ahmad, A., additional, Amossé, A., additional, Anbazhagan, P., additional, Andreyev, M., additional, Antov, A., additional, Appakutty, M., additional, Asher, D., additional, Aubry, S., additional, Baron, N., additional, Bassiere, N., additional, Berthe, M., additional, Bogdanovski, R., additional, Bosq, F., additional, Bredner, E., additional, Buettner, D., additional, Buromsky, M., additional, Cammarata, S., additional, Casas, R., additional, Chis, G. D., additional, Christou, A. A., additional, Coquerel, J.-P., additional, Corlan, R., additional, Cremaschini, C., additional, Crussaire, D., additional, Cuypers, J., additional, Dennefeld, M., additional, Descamps, P., additional, Devyatkin, A., additional, Dimitrov, D., additional, Dorokhova, T. N., additional, Dorokhov, N. I., additional, Dourneau, G., additional, Dueñas, M., additional, Dumitrescu, A., additional, Emelianov, N., additional, Ferrara, D., additional, Fiel, D., additional, Fienga, A., additional, Flatres, T., additional, Foglia, S., additional, Garlitz, J., additional, Gerbos, J., additional, Gilbert, R., additional, Goncalves, R. M. D., additional, Gonzãles, D., additional, Gorda, S. Yu., additional, Gorshanov, D. L., additional, Hansen, M. W., additional, Harrington, M., additional, Irsmambetova, T. R., additional, Ito, Y., additional, Ivanova, V., additional, Izmailov, I. S., additional, Khovritchev, M. Yu., additional, Khrutskaya, E. V., additional, Kieken, J., additional, Kiseleva, T. P., additional, Kuppuswamy, K., additional, Lainey, V., additional, Lavayssiére, M., additional, Lazzarotti, P., additional, Le Campion, J.-F., additional, Lellouch, E., additional, Li, Z. L., additional, Lo Savio, E., additional, Lou, M., additional, Magny, E., additional, Manek, J., additional, Marinello, W., additional, Marino, G., additional, McAuliffe, J. P., additional, Michelli, M., additional, Moldovan, D., additional, Montagnac, S., additional, Moorthy, V., additional, Nickel, O., additional, Nier, J. M., additional, Noel, T., additional, Noyelles, B., additional, Oksanen, A., additional, Parrat, D., additional, Pauwels, T., additional, Peng, Q. Y., additional, Pizzetti, G., additional, Priban, V., additional, Ramachandran, B., additional, Rambaux, N., additional, Rapaport, M., additional, Rapavy, P., additional, Rau, G., additional, Sacré, J.-J., additional, Sada, P. V., additional, Salvaggio, F., additional, Sarlin, P., additional, Sciuto, C., additional, Selvakumar, G., additional, Sergeyev, A., additional, Sidorov, M., additional, Sorescu, S., additional, Spampinato, S. A., additional, Stellmacher, I., additional, Trunkovsky, E., additional, Tejfel, V., additional, Tudose, V., additional, Turcu, V., additional, Ugarte, I., additional, Vantyghem, P., additional, Vasundhara, R., additional, Vaubaillon, J., additional, Velu, C., additional, Venkataramana, A. K., additional, Vidal-Sãinz, J., additional, Vienne, A., additional, Vilar, J., additional, Vingerhoets, P., additional, and Vollman, W., additional

Published
2008
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193. Effectiveness of Hospital-Based Video Interaction Guidance on Parental Interactive Behavior, Bonding, and Stress After Preterm Birth: A Randomized Controlled Trial.

Author

Hoffenkamp, Hannah N., Tooten, Anneke, Hall, Ruby A. S., Braeken, Johan, Eliëns, Marij P. J., Vingerhoets, Ad J. J. M., and van Bakel, Hedwig J. A.

Subjects
PARENT-infant psychotherapy, PREMATURE infants -- Hospital care, PSYCHOLOGICAL well-being, PARENT-child relationships, TREATMENT effectiveness, RANDOMIZED controlled trials, SELF-report inventories
Abstract

Objective: This study examined the effectiveness of hospital-based Video Interaction Guidance (VIG; Eliens, 2010; Kennedy, Landor, & Todd, 2011) for mothers and fathers of infants born preterm (25-37 weeks of gestation). Method: VIG is a preventive video-feedback intervention to support the parent-infant relationship. One hundred fifty families (150 infants, 150 mothers, 144 fathers) participated in a pragmatic randomized controlled trial to evaluate the effects of VIG as adjunct to standard hospital care. Primary outcome was parental interactive behavior (sensitivity, intrusiveness, and withdrawal) as observed in videotaped dyadic parent-infant interaction. Secondary outcomes comprised parental bonding, stress responses, and psychological well-being based on self-report. The intervention effects were assessed at baseline, mid-intervention, 3-week, 3-month, and 6-month follow-ups. Data were analyzed on an intention-to-treat basis, using multilevel modeling and analyses of covariance. Results: VIG proved to be effective in enhancing sensitive behavior and diminishing withdrawn behavior in mothers (Cohen's d range = .24-.44) and in fathers (d range: .54 -60). The positive effects of VIG were particularly found in mothers who experienced the preterm birth as very traumatic (d range = .80-1.04). The intervention, however, did not change parents' intrusive behavior. Analyses additionally revealed positive effects on parental bonding, especially for fathers, yet no significant effects on stress and well-being were detected. Conclusions: The results indicate that VIG is a useful addition to standard hospital care, reducing the possible negative impact of preterm birth on the parent-infant relationship. VIG appeared particularly beneficial for fathers, and for mothers with traumatic birth experiences. High levels of parental intrusiveness, however, need complementary intervention. [ABSTRACT FROM AUTHOR]

Published
2015
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194. The PHEMU97 catalogue of observations of the mutual phenomena of the Galilean satellites of Jupiter

Author

Arlot, J.-E., primary, Thuillot, W., additional, Ruatti, C., additional, Akasawa, H., additional, Baroni, S., additional, Beisker, W., additional, Berthier, J., additional, Blanco, C., additional, Boonstra, J., additional, Bourgeois, J., additional, Bulder, H., additional, Casas, R., additional, Castano, J. G., additional, Colas, F., additional, Collins, D., additional, Cuypers, J., additional, Czech, W., additional, D'Ambrosio, V., additional, Denzau, H., additional, Descamps, P., additional, Dimitrescu, A., additional, Dinakarian, N., additional, Dourneau, G., additional, Emelyanov, N., additional, Enriquez, J. M., additional, Fernandez, J. M., additional, Fernandez-Barba, D., additional, Flatres, T., additional, Foglia, S., additional, Goncalves, M., additional, Guhl, K., additional, Helmer, G., additional, Hirose, T., additional, Irsmambetova, T. R., additional, Krobusek, B. A., additional, Lecacheux, J., additional, Le Campion, J.-F., additional, Lou, M., additional, Mallama, A., additional, Marchis, F., additional, Navarro, M. A. S., additional, Nelson, P., additional, Okura, N., additional, Park, J., additional, Pauwels, T., additional, Pluchino, S., additional, Priban, V., additional, Rapaport, M., additional, Sacré, J.-J., additional, Salvaggio, F., additional, Sanchez, M. A., additional, Sanchez-Bajo, F., additional, Stefanescu, G., additional, Tanga, P., additional, Tejfel, V. G., additional, Trisan, J. L., additional, Trunkovsky, E. M., additional, Van Gestel, J., additional, Vandenbulcke, G., additional, Vasundhara, R., additional, Vass, G., additional, Vingerhoets, P., additional, Vu, D. T., additional, and Wilds, R. T., additional

Published
2006
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196. Updated clinical practice recommendations for managing adults with 22q11.2 deletion syndrome

Author

Boot, Erik, Óskarsdóttir, Sólveig, Loo, Joanne C.Y., Crowley, Terrence Blaine, Orchanian-Cheff, Ani, Andrade, Danielle M., Arganbright, Jill M., Castelein, René M., Cserti-Gazdewich, Christine, de Reuver, Steven, Fiksinski, Ania M., Klingberg, Gunilla, Lang, Anthony E., Mascarenhas, Maria R., Moss, Edward M., Nowakowska, Beata Anna, Oechslin, Erwin, Palmer, Lisa, Repetto, Gabriela M., Reyes, Nikolai Gil D., Schneider, Maude, Silversides, Candice, Sullivan, Kathleen E., Swillen, Ann, van Amelsvoort, Therese A.M.J., Van Batavia, Jason P., Vingerhoets, Claudia, McDonald-McGinn, Donna M., and Bassett, Anne S.

Abstract

This review aimed to update the clinical practice guidelines for managing adults with 22q11.2 deletion syndrome (22q11.2DS). The 22q11.2 Society recruited expert clinicians worldwide to revise the original clinical practice guidelines for adults in a stepwise process according to best practices: (1) a systematic literature search (1992-2021), (2) study selection and synthesis by clinical experts from 8 countries, covering 24 subspecialties, and (3) formulation of consensus recommendations based on the literature and further shaped by patient advocate survey results. Of 2441 22q11.2DS-relevant publications initially identified, 2344 received full-text review, with 2318 meeting inclusion criteria (clinical care relevance to 22q11.2DS) including 894 with potential relevance to adults. The evidence base remains limited. Thus multidisciplinary recommendations represent statements of current best practice for this evolving field, informed by the available literature. These recommendations provide guidance for the recognition, evaluation, surveillance, and management of the many emerging and chronic 22q11.2DS-associated multisystem morbidities relevant to adults. The recommendations also address key genetic counseling and psychosocial considerations for the increasing numbers of adults with this complex condition.

Published
2023
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197. Updated clinical practice recommendations for managing children with 22q11.2 deletion syndrome

Author

Óskarsdóttir, Sólveig, Boot, Erik, Crowley, Terrence Blaine, Loo, Joanne C.Y., Arganbright, Jill M., Armando, Marco, Baylis, Adriane L., Breetvelt, Elemi J., Castelein, René M., Chadehumbe, Madeline, Cielo, Christopher M., de Reuver, Steven, Eliez, Stephan, Fiksinski, Ania M., Forbes, Brian J., Gallagher, Emily, Hopkins, Sarah E., Jackson, Oksana A., Levitz-Katz, Lorraine, Klingberg, Gunilla, Lambert, Michele P., Marino, Bruno, Mascarenhas, Maria R., Moldenhauer, Julie, Moss, Edward M., Nowakowska, Beata Anna, Orchanian-Cheff, Ani, Putotto, Carolina, Repetto, Gabriela M., Schindewolf, Erica, Schneider, Maude, Solot, Cynthia B., Sullivan, Kathleen E., Swillen, Ann, Unolt, Marta, Van Batavia, Jason P., Vingerhoets, Claudia, Vorstman, Jacob, Bassett, Anne S., and McDonald-McGinn, Donna M.

Abstract

This review aimed to update the clinical practice guidelines for managing children and adolescents with 22q11.2 deletion syndrome (22q11.2DS). The 22q11.2 Society, the international scientific organization studying chromosome 22q11.2 differences and related conditions, recruited expert clinicians worldwide to revise the original 2011 pediatric clinical practice guidelines in a stepwise process: (1) a systematic literature search (1992-2021), (2) study selection and data extraction by clinical experts from 9 different countries, covering 24 subspecialties, and (3) creation of a draft consensus document based on the literature and expert opinion, which was further shaped by survey results from family support organizations regarding perceived needs. Of 2441 22q11.2DS-relevant publications initially identified, 2344 received full-text reviews, including 1545 meeting criteria for potential relevance to clinical care of children and adolescents. Informed by the available literature, recommendations were formulated. Given evidence base limitations, multidisciplinary recommendations represent consensus statements of good practice for this evolving field. These recommendations provide contemporary guidance for evaluation, surveillance, and management of the many 22q11.2DS-associated physical, cognitive, behavioral, and psychiatric morbidities while addressing important genetic counseling and psychosocial issues.

Published
2023
Full Text
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