697 results on '"Vinci, Maria"'
Search Results
152. Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse.
- Author
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Richardson, Stacey, Hill, Rebecca M, Kui, Christopher, Lindsey, Janet C, Grabovksa, Yura, Keeling, Claire, Pease, Louise, Bashton, Matthew, Crosier, Stephen, Vinci, Maria, André, Nicolas, Figarella-Branger, Dominique, Hansford, Jordan R, Lastowska, Maria, Zakrzewski, Krzysztof, Jorgensen, Mette, Pickles, Jessica C, Taylor, Michael D, Pfister, Stefan M, and Wharton, Stephen B
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- 2022
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153. Quality for home palliative care: an Italian metropolitan multicentre JCI-certified model
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Rizzi, Franco, Pizzuto, Massimo, Lodetti, Laura, Corli, Oscar, Da, Daria, Damiani, Maria Eugenia, Mihali, Dorian, Piva, Laura, Saita, Luigi, Vinci, Maria, and Bonaldi, Antonio
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- 2011
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154. Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG
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Pericoli, Giulia, primary, Petrini, Stefania, additional, Giorda, Ezio, additional, Ferretti, Roberta, additional, Ajmone-Cat, Maria Antonietta, additional, Court, Will, additional, Conti, Libenzio Adrian, additional, De Simone, Roberta, additional, Bencivenga, Paola, additional, Palma, Alessia, additional, Di Giannatale, Angela, additional, Jones, Chris, additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, de Billy, Emmanuel, additional, Locatelli, Franco, additional, and Vinci, Maria, additional
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- 2020
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155. Infantile/Congenital High-Grade Gliomas: Molecular Features and Therapeutic Perspectives
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Ceglie, Giulia, primary, Vinci, Maria, additional, Carai, Andrea, additional, Rossi, Sabrina, additional, Colafati, Giovanna Stefania, additional, Cacchione, Antonella, additional, Tornesello, Assunta, additional, Miele, Evelina, additional, Locatelli, Franco, additional, and Mastronuzzi, Angela, additional
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- 2020
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156. The weight of pre-existing cofactors for liver disease progression in patients who successfully eradicated chronic hepatitis C viral infection: an interim analysis in the PITER cohort
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Kondili, Loreta, primary, Quaranta, Maria Giovanna, additional, Monti, Monica, additional, Amoruso, Daniela Caterina, additional, Filomia, Roberto, additional, Biliotti, Elisa, additional, Iannone, Andrea, additional, Ieluzzi, Donatella, additional, Coco, Barbara, additional, Russo, Francesco Paolo, additional, Beretta, Ilaria, additional, Parruti, Giustino, additional, Blanc, Pierluigi, additional, Vinci, Maria, additional, Cossiga, Valentina, additional, Degasperi, Elisabetta, additional, Chemello, Liliana, additional, Massari, Marco, additional, Badia, Lorenzo, additional, Puoti, Massimo, additional, Bruno, Serena, additional, De Siena, Martina, additional, Panetta, Valentina, additional, and Aghemo, Alessio, additional
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- 2020
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157. Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
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Clarke, Matthew, primary, Mackay, Alan, additional, Ismer, Britta, additional, Pickles, Jessica C., additional, Tatevossian, Ruth G., additional, Newman, Scott, additional, Bale, Tejus A., additional, Stoler, Iris, additional, Izquierdo, Elisa, additional, Temelso, Sara, additional, Carvalho, Diana M., additional, Molinari, Valeria, additional, Burford, Anna, additional, Howell, Louise, additional, Virasami, Alex, additional, Fairchild, Amy R., additional, Avery, Aimee, additional, Chalker, Jane, additional, Kristiansen, Mark, additional, Haupfear, Kelly, additional, Dalton, James D., additional, Orisme, Wilda, additional, Wen, Ji, additional, Hubank, Michael, additional, Kurian, Kathreena M., additional, Rowe, Catherine, additional, Maybury, Mellissa, additional, Crosier, Stephen, additional, Knipstein, Jeffrey, additional, Schüller, Ulrich, additional, Kordes, Uwe, additional, Kram, David E., additional, Snuderl, Matija, additional, Bridges, Leslie, additional, Martin, Andrew J., additional, Doey, Lawrence J., additional, Al-Sarraj, Safa, additional, Chandler, Christopher, additional, Zebian, Bassel, additional, Cairns, Claire, additional, Natrajan, Rachael, additional, Boult, Jessica K.R., additional, Robinson, Simon P., additional, Sill, Martin, additional, Dunkel, Ira J., additional, Gilheeney, Stephen W., additional, Rosenblum, Marc K., additional, Hughes, Debbie, additional, Proszek, Paula Z., additional, Macdonald, Tobey J., additional, Preusser, Matthias, additional, Haberler, Christine, additional, Slavc, Irene, additional, Packer, Roger, additional, Ng, Ho-Keung, additional, Caspi, Shani, additional, Popović, Mara, additional, Faganel Kotnik, Barbara, additional, Wood, Matthew D., additional, Baird, Lissa, additional, Davare, Monika Ashok, additional, Solomon, David A., additional, Olsen, Thale Kristin, additional, Brandal, Petter, additional, Farrell, Michael, additional, Cryan, Jane B., additional, Capra, Michael, additional, Karremann, Michael, additional, Schittenhelm, Jens, additional, Schuhmann, Martin U., additional, Ebinger, Martin, additional, Dinjens, Winand N.M., additional, Kerl, Kornelius, additional, Hettmer, Simone, additional, Pietsch, Torsten, additional, Andreiuolo, Felipe, additional, Driever, Pablo Hernáiz, additional, Korshunov, Andrey, additional, Hiddingh, Lotte, additional, Worst, Barbara C., additional, Sturm, Dominik, additional, Zuckermann, Marc, additional, Witt, Olaf, additional, Bloom, Tabitha, additional, Mitchell, Clare, additional, Miele, Evelina, additional, Colafati, Giovanna Stefania, additional, Diomedi-Camassei, Francesca, additional, Bailey, Simon, additional, Moore, Andrew S., additional, Hassall, Timothy E.G., additional, Lowis, Stephen P., additional, Tsoli, Maria, additional, Cowley, Mark J., additional, Ziegler, David S., additional, Karajannis, Matthias A., additional, Aquilina, Kristian, additional, Hargrave, Darren R., additional, Carceller, Fernando, additional, Marshall, Lynley V., additional, von Deimling, Andreas, additional, Kramm, Christof M., additional, Pfister, Stefan M., additional, Sahm, Felix, additional, Baker, Suzanne J., additional, Mastronuzzi, Angela, additional, Carai, Andrea, additional, Vinci, Maria, additional, Capper, David, additional, Popov, Sergey, additional, Ellison, David W., additional, Jacques, Thomas S., additional, Jones, David T.W., additional, and Jones, Chris, additional
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- 2020
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158. Measuring the Confluence of iPSCs using an Automated Imaging System.
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Magliocca, Valentina, primary, Vinci, Maria, primary, Persichini, Tiziana, primary, Locatelli, Franco, primary, Tartaglia, Marco, primary, and Compagnucci, Claudia, primary
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- 2020
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159. When Good Guys Turn Bad: Bone Marrow’s and Hematopoietic Stem Cells’ Role in the Pathobiology of Diabetic Complications
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Vinci, Maria Cristina, primary, Gambini, Elisa, additional, Bassetti, Beatrice, additional, Genovese, Stefano, additional, and Pompilio, Giulio, additional
- Published
- 2020
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160. SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors
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Giuliani, Giulio, primary, Vumbaca, Simone, additional, Fuoco, Claudia, additional, Gargioli, Cesare, additional, Giorda, Ezio, additional, Massacci, Giorgia, additional, Palma, Alessandro, additional, Reggio, Alessio, additional, Riccio, Federica, additional, Vinci, Maria, additional, Castagnoli, Luisa, additional, and Cesareni, Gianni, additional
- Published
- 2020
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161. Migratory flow and hepatitis delta infection in Italy: A new challenge at the beginning of the third millennium
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Stroffolini, Tommaso, primary, Ciancio, Alessia, additional, Furlan, Caterina, additional, Vinci, Maria, additional, Fontana, Rosanna, additional, Russello, Maurizio, additional, Colloredo, Guido, additional, Morisco, Filomena, additional, Coppola, Nicola, additional, Babudieri, Sergio, additional, Ferrigno, Luigina, additional, Sagnelli, Caterina, additional, Sagnelli, Evangelista, additional, Verzon, Giulia, additional, Latanza, Arianna, additional, Picciotto, Viviana, additional, Niro, Grazia Anna, additional, Benigno, Rosa Grazia, additional, Pontillo, Giuseppina, additional, Messina, Vincenzo, additional, and Fiore, Vito, additional
- Published
- 2020
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162. Comparison of three therapeutic regimens for genotype‐3 hepatitis C virus infection in a large real‐life multicentre cohort
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Soria, Alessandro, primary, Fava, Marco, additional, Bernasconi, Davide P., additional, Lapadula, Giuseppe, additional, Colella, Elisa, additional, Valsecchi, Maria G., additional, Migliorino, Guglielmo M., additional, D'Ambrosio, Roberta, additional, Landonio, Simona, additional, Schiavini, Monica, additional, Spinetti, Angiola, additional, Carriero, Canio, additional, Degasperi, Elisabetta, additional, Cologni, Giuliana, additional, Gatti, Federico, additional, Viganò, Paolo, additional, Hasson, Hamid, additional, Uberti‐Foppa, Caterina, additional, Pasulo, Luisa, additional, Baiguera, Chiara, additional, Rossotti, Roberto, additional, Vinci, Maria, additional, Puoti, Massimo, additional, Giorgini, Alessia, additional, Menzaghi, Barbara, additional, Lombardi, Andrea, additional, Pan, Angelo, additional, Aghemo, Alessio, additional, Grossi, Paolo A., additional, Boldizzoni, Roberto, additional, Colombo, Silvia, additional, Viganò, Mauro, additional, Rumi, Maria G., additional, Del Poggio, Paolo, additional, Valenti, Luca, additional, Giglio, Omar, additional, De Bona, Anna, additional, d'Arminio Monforte, Antonella, additional, Colombo, Alberto, additional, Spinelli, Ombretta, additional, Pigozzi, Marie G., additional, Molteni, Chiara, additional, Bonfanti, Paolo, additional, Terreni, Natalia, additional, Perini, Paolo, additional, Capretti, Andrea, additional, Bella, Daniele, additional, Liani, Cecilia, additional, Polo, Silvia, additional, Aimo, Gianpiero, additional, Pagnucco, Layla, additional, Bhoori, Sherrie, additional, Centenaro, Riccardo, additional, Graffeo, Massimo, additional, Ciaccio, Antonio, additional, Dionigi, Elena, additional, Lazzaroni, Sergio, additional, Carderi, Isabella, additional, Di Marco, Mariella, additional, Rizzardini, Giuliano, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, and Fagiuoli, Stefano, additional
- Published
- 2020
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163. Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography
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Li, Jin, primary, Zormpas-Petridis, Konstantinos, additional, Boult, Jessica K.R., additional, Reeves, Emma L., additional, Heindl, Andreas, additional, Vinci, Maria, additional, Lopes, Filipa, additional, Cummings, Craig, additional, Springer, Caroline J., additional, Chesler, Louis, additional, Jones, Chris, additional, Bamber, Jeffrey C., additional, Yuan, Yinyin, additional, Sinkus, Ralph, additional, Jamin, Yann, additional, and Robinson, Simon P., additional
- Published
- 2019
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164. Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin
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Stowe, Cassandra L, primary, Burley, Thomas A, additional, Allan, Helen, additional, Vinci, Maria, additional, Kramer-Marek, Gabriela, additional, Ciobota, Daniela M, additional, Parkinson, Gary N, additional, Southworth, Tara L, additional, Agliardi, Giulia, additional, Hotblack, Alastair, additional, Lythgoe, Mark F, additional, Branchini, Bruce R, additional, Kalber, Tammy L, additional, Anderson, James C, additional, and Pule, Martin A, additional
- Published
- 2019
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- View/download PDF
165. Signa Lapicidinarum e tracciati di cantiere per la comprensione dell’edilizia archeologica: il caso del Foro Provinciale di Tarraco (Hispania Citerior)
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Ottati, Adalberto, primary and Vinci, Maria Serena, additional
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- 2019
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166. La monumentalizzazione delle Hispaniae: alcune riflessioni su progettualità e realizzazione del Foro Provinciale di Tarraco
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Vinci, Maria Serena, Ottati, Adalberto, Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge, Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Universidad Pablo de Olavide [Sevilla] (UPO), and Vinci, Maria Serena
- Subjects
[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory ,[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory ,[SHS] Humanities and Social Sciences ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
International audience
- Published
- 2018
167. Human mature endothelial cells modulate peripheral blood mononuclear cell differentiation toward an endothelial phenotype
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Bellik, Lydia, Musilli, Claudia, Vinci, Maria Cristina, Ledda, Fabrizio, and Parenti, Astrid
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- 2008
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168. Dataset related to the article 'Abnormal DNA Methylation Induced by Hyperglycemia Reduces CXCR4 Gene Expression in CD34+ Stem Cells'
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Vigorelli Vera, Resta Jessica, Bianchessi Valentina, Andrea, Lauri, Bassetti Beatrice, Agrifoglio Marco, Pesce Maurizio, Polvani Gianluca, Bonalumi Giorgia, Cavallotti Laura, Alamanni Francesco, Genovese Stefano, Giulio, Pompilio, and Vinci Maria Cristina
- Abstract
This record contains raw data related to the article “Abnormal DNA Methylation Induced by Hyperglycemia Reduces CXCR 4 Gene Expression in CD 34+ Stem Cells." Abstract Background CD 34+ stem/progenitor cells are involved in vascular homeostasis and in neovascularization of ischemic tissues. The number of circulating CD 34+ stem cells is a predictive biomarker of adverse cardiovascular outcomes in diabetic patients. Here, we provide evidence that hyperglycemia can be "memorized" by the stem cells through epigenetic changes that contribute to onset and maintenance of their dysfunction in diabetes mellitus. Methods and Results Cord-blood-derived CD 34+ stem cells exposed to high glucose displayed increased reactive oxygen species production, overexpression of p66shc gene, and downregulation of antioxidant genes catalase and manganese superoxide dismutase when compared with normoglycemic cells. This altered oxidative state was associated with impaired migration ability toward stromal-cell-derived factor 1 alpha and reduced protein and mRNA expression of the C-X-C chemokine receptor type 4 ( CXCR 4) receptor. The methylation analysis by bisulfite Sanger sequencing of the CXCR 4 promoter revealed a significant increase in DNA methylation density in high-glucose CD 34+ stem cells that negatively correlated with mRNA expression (Pearson r=-0.76; P=0.004). Consistently, we found, by chromatin immunoprecipitation assay, a more transcriptionally inactive chromatin conformation and reduced RNA polymerase II engagement on the CXCR 4 promoter. Notably, alteration of CXCR 4 DNA methylation, as well as transcriptional and functional defects, persisted in high-glucose CD 34+ stem cells despite recovery in normoglycemic conditions. Importantly, such an epigenetic modification was thoroughly confirmed in bone marrow CD 34+ stem cells isolated from sternal biopsies of diabetic patients undergoing coronary bypass surgery. Conclusions CD 34+ stem cells "memorize" the hyperglycemic environment in the form of epigenetic modifications that collude to alter CXCR 4 receptor expression and migration., This work was supported by Ricerca Finalizzata, Ministero della Salute (PE-2011-02348537)
- Published
- 2019
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169. SCA1 expression variability governs Fibro/adipogenic progenitor behaviour
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Giuliani, Giulio, Fuoco, Claudia, Vumbaca, Simone, Giorda, Ezio, Vinci, Maria, Castagnoli, Luisa, and Cesareni, Gianni
- Published
- 2019
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170. Economic Consequences of Investing in Anti-HCV Antiviral Treatment from the Italian NHS Perspective: A Real-World-Based Analysis of PITER Data
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Marcellusi, Andrea, Viti, Raffaella, Kondili, Loreta A., Rosato, Stefano, Vella, Stefano, Mennini, Francesco Saverio, Kondili, L. A., Vella, S., Quaranta, M. G., Rosato, S., Tosti, M. E., Weimer, L. E., Ferrigno, L., D’Angelo, F., Falzano, L., Benedetti, A., Schiadà, L., Cucco, M., Giacometti, A., Brescini, L., Castelletti, S., Drenaggi, D., Mazzaro, C., Angarano, G., Milella, M., Di Leo, A., Rendina, M., Contaldo, A., Iannone, A., La Fortezza, F., Rizzi, M., Cologni, G., Bolondi, L., Benevento, F., Serio, I., Andreone, P., Caraceni, P., Guarneri, V., Margotti, M., Simonetti, G., Mazzella, G., Verucchi, G., Donati, V., Mian, Peter, Rimenti, G., Rossini, A., Contessi, G. B., Castelli, Fulvio, Zaltron, S., Spinetti, A., Odolini, S., Leandro, G., Cozzolongo, R., Zappimbulso, M., Russello, M., Benigno, R., Coco, C., Torti, C., Costa, C., Greco, G., Mazzitelli, M., Pisani, V., Cosco, Lucia, Quintieri, F., De Siena, Martina, Giancotti, F., Vecchiet, J., Falasca, K., Mastroianni, A., Apuzzo, G., Chidichimo, L., Foschi, F. G., Dall’Aglio, A. C., Libanore, M., Segala, D., Sighinolfi, L., Bartolozzi, D., Salomoni, E., Blanc, P., Baragli, F., DelundefinedPin, B., Mariabelli, E., Mazzotta, F., Poggi, A., Zignego, A. L., Monti, M., Madia, Francesca, Xheka, A., Cela, E. M., Santantonio, T. A., Bruno, S. R., Viscoli, C., Alessandrini, A. I., Curti, C., DiundefinedBiagio, A., Nicolini, L. A., Balletto, E., Mastroianni, Chiara, Blerta, K., Prati, D., Raffaele, L., Andreoletti, M., Perboni, G., Costa, P., Manzini, L., Raimondo, G., Filomia, R., Lazzarin, A., Morsica, G., Salpietro, S., Puoti, M., Baiguera, C., Vassalli, S., Rumi, M. G., Labanca, S., Zuin, M., Giorgini, A., Orellana, D., D’ArminioundefinedMonforte, A., Debona, A., Solaro, S., Fargion, S., Valenti, L., Periti, G., Pelusi, S., Galli, M., Calvi, E., Milazzo, L., Peri, A., Lampertico, P., Borghi, Margherita, D’Ambrosio, R., Degasperi, E., Vinci, Maria Rosaria, Villa, E., Bernabucci, V., Bristot, Luca, Pereira, F., Chessa, L., Pasetto, M. C., Loi, M., Gori, A., Beretta, I., Pastore, V., Soria, A., Strazzabosco, M., Ciaccio, A., Gemma, M., Borgia, G., Foggia, A., Zappulo, E., Gentile, I., Buonomo, A. R., Abrescia, N., Maddaloni, A., Caporaso, N., Morisco, F., Camera, S., Donnarumma, L., Coppola, C., Amoruso, D. C., Staiano, L., Saturnino, M. R., Coppola, N., Martini, S., Monari, C., Federico, Alex, Dallio, M., Loguercio, C., Gaeta, G. B., Brancaccio, G., Nardone, G., Sgamato, C., D’Adamo, G., Alberti, A., Gonzo, M., Piovesan, S., Chemello, L., Buggio, A., Cavalletto, L., Barbaro, F., Castelli, Enrico, Floreani, A., Cazzagon, N., Franceschet, I., Russo, F. P., Zanetto, A., Franceschet, E., Madonia, S., Cannizzaro, Maria Chiara, Montalto, G., Licata, A., Capitano, A. R., Craxì, A., Petta, S., Calvaruso, V., Rini, F., Ferrari, C., Negri, E., Orlandini, A., Pesci, M., Bruno, R., Lombardi, A., Zuccaro, V., Gulminetti, R., Asti, A., Villaraggia, M., Mondelli, M., Ludovisi, S., Baldelli, F., Di Candilo, F., Parruti, G., Di Stefano, Paolo, Sozio, F., Gizzi, M. C., Brunetto, M. R., Colombatto, P., Coco, B., Surace, L., Foti, G., Pellicano, S., Fornaciari, G., Schianchi, S., Vignoli, P., Massari, M., Corsini, R., Garlassi, E., Ballardini, G., Andreoni, M., Cerva, C., Angelico, M., Gasbarrini, Antonio, Siciliano, M., Nosotti, L., Taliani, G., Biliotti, E., Santori, M., Spaziante, M., Tamburini, F., Vullo, V., D’Ettorre, G., Cavallari, E. N., Gebremeskel, T. S., Pavone, P., Cauda, Roberto, Cingolani, Antonella, Lamonica, S., D’Offizi, G., Lionetti, R., Visco Comandini, U., Grieco, Antonio, D’Aversa, F., Picardi, A., De Vincentis, A., Galati, G., Gallo, Patrizia, Dell’Unto, C., Aghemo, A., Gatti Comini, A., Persico, M., Masarone, M., Anselmo, M., De Leo, P., Marturano, Monia, Brunelli, E., Ridolfi, F., Schimizzi, A. M., Ayoubi Khajekini, M., Framarin, L., Di Perri, G., Cariti, G., Boglione, L., Cardellino, C., Marinaro, L., Saracco, G. M., Ciancio, A., Toniutto, P., Alterini, G., Capra, F., Ieluzzi, D., Marcellusi, A, Viti, R, Kondili, L, Rosato, S, Vella, S, Mennini, F, Quaranta, M, Tosti, M, Weimer, L, Ferrigno, L, D'Angelo, F, Falzano, L, Benedetti, A, Schiada, L, Cucco, M, Giacometti, A, Brescini, L, Castelletti, S, Drenaggi, D, Mazzaro, C, Angarano, G, Milella, M, Dileo, A, Rendina, M, Contaldo, A, Iannone, A, La Fortezza, F, Rizzi, M, Cologni, G, Bolondi, L, Benevento, F, Serio, I, Andreone, P, Caraceni, P, Guarneri, V, Margotti, M, Simonetti, G, Mazzella, G, Verucchi, G, Donati, V, Mian, P, Rimenti, G, Rossini, A, Contessi, G, Castelli, F, Zaltron, S, Spinetti, A, Odolini, S, Leandro, G, Cozzolongo, R, Zappimbulso, M, Russello, M, Benigno, R, Coco, C, Torti, C, Costa, C, Greco, G, Mazzitelli, M, Pisani, V, Cosco, L, Quintieri, F, Desiena, M, Giancotti, F, Vecchiet, J, Falasca, K, Mastroianni, A, Apuzzo, G, Chidichimo, L, Foschi, F, Dall'Aglio, A, Libanore, M, Segala, D, Sighinolfi, L, Bartolozzi, D, Salomoni, E, Blanc, P, Baragli, F, Delpin, B, Mariabelli, E, Mazzotta, F, Poggi, A, Zignego, A, Monti, M, Madia, F, Xheka, A, Cela, E, Santantonio, T, Bruno, S, Viscoli, C, Alessandrini, A, Curti, C, Dibiagio, A, Nicolini, L, Balletto, E, Mastroianni, C, Blerta, K, Prati, D, Raffaele, L, Andreoletti, M, Perboni, G, Costa, P, Manzini, L, Raimondo, G, Filomia, R, Lazzarin, A, Morsica, G, Salpietro, S, Puoti, M, Baiguera, C, Vassalli, S, Rumi, M, Labanca, S, Zuin, M, Giorgini, A, Orellana, D, D'Arminiomonforte, A, Debona, A, Solaro, S, Fargion, S, Valenti, L, Periti, G, Pelusi, S, Galli, M, Calvi, E, Milazzo, L, Peri, A, Lampertico, P, Borghi, M, D'Ambrosio, R, Degasperi, E, Vinci, M, Villa, E, Bernabucci, V, Bristot, L, Pereira, F, Chessa, L, Pasetto, M, Loi, M, Gori, A, Beretta, I, Pastore, V, Soria, A, Strazzabosco, M, Ciaccio, A, Gemma, M, Borgia, G, Foggia, A, Zappulo, E, Gentile, I, Buonomo, A, Abrescia, N, Maddaloni, A, Caporaso, N, Morisco, F, Camera, S, Donnarumma, L, Coppola, C, Amoruso, D, Staiano, L, Saturnino, M, Coppola, N, Martini, S, Monari, C, Federico, A, Dallio, M, Loguercio, C, Gaeta, G, Brancaccio, G, Nardone, G, Sgamato, C, D'Adamo, G, Alberti, A, Gonzo, M, Piovesan, S, Chemello, L, Buggio, A, Cavalletto, L, Barbaro, F, Castelli, E, Floreani, A, Cazzagon, N, Franceschet, I, Russo, F, Zanetto, A, Franceschet, E, Madonia, S, Cannizzaro, M, Montalto, G, Licata, A, Capitano, A, Craxi, A, Petta, S, Calvaruso, V, Rini, F, Ferrari, C, Negri, E, Orlandini, A, Pesci, M, Bruno, R, Lombardi, A, Zuccaro, V, Gulminetti, R, Asti, A, Villaraggia, M, Mondelli, M, Ludovisi, S, Baldelli, F, Di Candilo, F, Parruti, G, Di Stefano, P, Sozio, F, Gizzi, M, Brunetto, M, Colombatto, P, Coco, B, Surace, L, Foti, G, Pellicano, S, Fornaciari, G, Schianchi, S, Vignoli, P, Massari, M, Corsini, R, Garlassi, E, Ballardini, G, Andreoni, M, Cerva, C, Angelico, M, Gasbarrini, A, Siciliano, M, De Siena, M, Nosotti, L, Taliani, G, Biliotti, E, Santori, M, Spaziante, M, Tamburini, F, Vullo, V, D'Ettorre, G, Cavallari, E, Gebremeskel, T, Pavone, P, Cauda, R, Cingolani, A, Lamonica, S, D'Offizi, G, Lionetti, R, Visco Comandini, U, Grieco, A, D'Aversa, F, Picardi, A, De Vincentis, A, Galati, G, Gallo, P, Dell'Unto, C, Aghemo, A, Gatti Comini, A, Persico, M, Masarone, M, Anselmo, M, De Leo, P, Marturano, M, Brunelli, E, Ridolfi, F, Schimizzi, A, Ayoubi Khajekini, M, Framarin, L, Di Perri, G, Cariti, G, Boglione, L, Cardellino, C, Marinaro, L, Saracco, G, Ciancio, A, Toniutto, P, Alterini, G, Capra, F, Ieluzzi, D, Kondili LA, Vella S, Quaranta MG, Rosato S, Tosti ME, Weimer LE, Ferrigno L, D'Angelo F, Falzano L, Benedetti A, Schiadà L, Cucco M, Giacometti A, Brescini L, Castelletti S, Drenaggi D, Mazzaro C, Angarano G, Milella M, Di Leo A, Rendina M, Contaldo A, Iannone A, La Fortezza F, Rizzi M, Cologni G, Bolondi L, Benevento F, Serio I, Andreone P, Caraceni P, Guarneri V, Margotti M, Simonetti G, Mazzella G, Verucchi G, Donati V, Mian P, Rimenti G, Rossini A, Contessi GB, Castelli F, Zaltron S, Spinetti A, Odolini S, Leandro G, Cozzolongo R, Zappimbulso M, Russello M, Benigno R, Coco C, Torti C, Costa C, Greco G, Mazzitelli M, Pisani V, Cosco L, Quintieri F, De Siena M, Giancotti F, Vecchiet J, Falasca K, Mastroianni A, Apuzzo G, Chidichimo L, Foschi FG, Dall'Aglio AC, Libanore M, Segala D, Sighinolfi L, Bartolozzi D, Salomoni E, Blanc P, Baragli F, Del Pin B, Mariabelli E, Mazzotta F, Poggi A, Zignego AL, Monti M, Madia F, Xheka A, Cela EM, Santantonio TA, Bruno SR, Viscoli C, Alessandrini AI, Curti C, Di Biagio A, Nicolini LA, Balletto E, Mastroianni C, Blerta K, Prati D, Raffaele L, Andreoletti M, Perboni G, Costa P, Manzini L, Raimondo G, Filomia R, Lazzarin A, Morsica G, Salpietro S, Puoti M, Baiguera C, Vassalli S, Rumi MG, Labanca S, Zuin M, Giorgini A, Orellana D, D'Arminio Monforte A, Debona A, Solaro S, Fargion S, Valenti L, Periti G, Pelusi S, Galli M, Calvi E, Milazzo L, Peri A, Lampertico P, Borghi M, D'Ambrosio R, Degasperi E, Vinci M, Villa E, Bernabucci V, Bristot L, Pereira F, Chessa L, Pasetto MC, Loi M, Gori A, Beretta I, Pastore V, Soria A, Strazzabosco M, Ciaccio A, Gemma M, Borgia G, Foggia A, Zappulo E, Gentile I, Buonomo AR, Abrescia N, Maddaloni A, Caporaso N, Morisco F, Camera S, Donnarumma L, Coppola C, Amoruso DC, Staiano L, Saturnino MR, Coppola N, Martini S, Monari C, Federico A, Dallio M, Loguercio C, Gaeta GB, Brancaccio G, Nardone G, Sgamato C, D'Adamo G, Alberti A, Gonzo M, Piovesan S, Chemello L, Buggio A, Cavalletto L, Barbaro F, Castelli E, Floreani A, Cazzagon N, Franceschet I, Russo FP, Zanetto A, Franceschet E, Madonia S, Cannizzaro M, Montalto G, Licata A, Capitano AR, Craxì A, Petta S, Calvaruso V, Rini F, Ferrari C, Negri E, Orlandini A, Pesci M, Bruno R, Lombardi A, Zuccaro V, Gulminetti R, Asti A, Villaraggia M, Mondelli M, Ludovisi S, Baldelli F, Di Candilo F, Parruti G, Di Stefano P, Sozio F, Gizzi MC, Brunetto MR, Colombatto P, Coco B, Surace L, Foti G, Pellicano S, Fornaciari G, Schianchi S, Vignoli P, Massari M, Corsini R, Garlassi E, Ballardini G, Andreoni M, Cerva C, Angelico M, Gasbarrini A, Siciliano M, De Siena M, Nosotti L, Taliani G, Biliotti E, Santori M, Spaziante M, Tamburini F, Vullo V, D'Ettorre G, Cavallari EN, Gebremeskel TS, Pavone P, Cauda R, Cingolani A, Lamonica S, D'Offizi G, Lionetti R, Visco Comandini U, Grieco A, D'Aversa F, Picardi A, De Vincentis A, Galati G, Gallo P, Dell'Unto C, Aghemo A, Gatti Comini A, Persico M, Masarone M, Anselmo M, De Leo P, Marturano M, Brunelli E, Ridolfi F, Schimizzi AM, Ayoubi Khajekini M, Framarin L, Di Perri G, Cariti G, Boglione L, Cardellino C, Marinaro L, Saracco GM, Ciancio A, Toniutto P, Alterini G, Capra F, Ieluzzi D., Marcellusi, A., Viti, R., Kondili, L. A., Rosato, S., Vella, S., Mennini, F. S., Quaranta, M. G., Tosti, M. E., Weimer, L. E., Ferrigno, L., D'Angelo, F., Falzano, L., Benedetti, A., Schiada, L., Cucco, M., Giacometti, A., Brescini, L., Castelletti, S., Drenaggi, D., Mazzaro, C., Angarano, G., Milella, M., Dileo, A., Rendina, M., Contaldo, A., Iannone, A., La Fortezza, F., Rizzi, M., Cologni, G., Bolondi, L., Benevento, F., Serio, I., Andreone, P., Caraceni, P., Guarneri, V., Margotti, M., Simonetti, G., Mazzella, G., Verucchi, G., Donati, V., Mian, P., Rimenti, G., Rossini, A., Contessi, G. B., Castelli, F., Zaltron, S., Spinetti, A., Odolini, S., Leandro, G., Cozzolongo, R., Zappimbulso, M., Russello, M., Benigno, R., Coco, C., Torti, C., Costa, C., Greco, G., Mazzitelli, M., Pisani, V., Cosco, L., Quintieri, F., Desiena, M., Giancotti, F., Vecchiet, J., Falasca, K., Mastroianni, A., Apuzzo, G., Chidichimo, L., Foschi, F. G., Dall'Aglio, A. C., Libanore, M., Segala, D., Sighinolfi, L., Bartolozzi, D., Salomoni, E., Blanc, P., Baragli, F., Delpin, B., Mariabelli, E., Mazzotta, F., Poggi, A., Zignego, A. L., Monti, M., Madia, F., Xheka, A., Cela, E. M., Santantonio, T. A., Bruno, S. R., Viscoli, C., Alessandrini, A. I., Curti, C., Dibiagio, A., Nicolini, L. A., Balletto, E., Mastroianni, C., Blerta, K., Prati, D., Raffaele, L., Andreoletti, M., Perboni, G., Costa, P., Manzini, L., Raimondo, G., Filomia, R., Lazzarin, A., Morsica, G., Salpietro, S., Puoti, M., Baiguera, C., Vassalli, S., Rumi, M. G., Labanca, S., Zuin, M., Giorgini, A., Orellana, D., D'Arminiomonforte, A., Debona, A., Solaro, S., Fargion, S., Valenti, L., Periti, G., Pelusi, S., Galli, M., Calvi, E., Milazzo, L., Peri, A., Lampertico, P., Borghi, M., D'Ambrosio, R., Degasperi, E., Vinci, M., Villa, E., Bernabucci, V., Bristot, L., Pereira, F., Chessa, L., Pasetto, M. C., Loi, M., Gori, A., Beretta, I., Pastore, V., Soria, A., Strazzabosco, M., Ciaccio, A., Gemma, M., Borgia, G., Foggia, A., Zappulo, E., Gentile, I., Buonomo, A. R., Abrescia, N., Maddaloni, A., Caporaso, N., Morisco, F., Camera, S., Donnarumma, L., Coppola, C., Amoruso, D. C., Staiano, L., Saturnino, M. R., Coppola, N., Martini, S., Monari, C., Federico, A., Dallio, M., Loguercio, C., Gaeta, G. B., Brancaccio, G., Nardone, G., Sgamato, C., D'Adamo, G., Alberti, A., Gonzo, M., Piovesan, S., Chemello, L., Buggio, A., Cavalletto, L., Barbaro, F., Castelli, E., Floreani, A., Cazzagon, N., Franceschet, I., Russo, F. P., Zanetto, A., Franceschet, E., Madonia, S., Cannizzaro, M., Montalto, G., Licata, A., Capitano, A. R., Craxi, A., Petta, S., Calvaruso, V., Rini, F., Ferrari, C., Negri, E., Orlandini, A., Pesci, M., Bruno, R., Lombardi, A., Zuccaro, V., Gulminetti, R., Asti, A., Villaraggia, M., Mondelli, M., Ludovisi, S., Baldelli, F., Di Candilo, F., Parruti, G., Di Stefano, P., Sozio, F., Gizzi, M. C., Brunetto, M. R., Colombatto, P., Coco, B., Surace, L., Foti, G., Pellicano, S., Fornaciari, G., Schianchi, S., Vignoli, P., Massari, M., Corsini, R., Garlassi, E., Ballardini, G., Andreoni, M., Cerva, C., Angelico, M., Gasbarrini, A., Siciliano, M., De Siena, M., Nosotti, L., Taliani, G., Biliotti, E., Santori, M., Spaziante, M., Tamburini, F., Vullo, V., D'Ettorre, G., Cavallari, E. N., Gebremeskel, T. S., Pavone, P., Cauda, R., Cingolani, A., Lamonica, S., D'Offizi, G., Lionetti, R., Visco Comandini, U., Grieco, A., D'Aversa, F., Picardi, A., De Vincentis, A., Galati, G., Gallo, P., Dell'Unto, C., Aghemo, A., Gatti Comini, A., Persico, M., Masarone, M., Anselmo, M., De Leo, P., Marturano, M., Brunelli, E., Ridolfi, F., Schimizzi, A. M., Ayoubi Khajekini, M., Framarin, L., Di Perri, G., Cariti, G., Boglione, L., Cardellino, C., Marinaro, L., Saracco, G. M., Ciancio, A., Toniutto, P., Alterini, G., Capra, F., Ieluzzi, D., Marcellusi, Andrea, Viti, Raffaella, Kondili, Loreta A., Rosato, Stefano, Vella, Stefano, Mennini, Francesco Saverio, Kondili, L.A., Quaranta, M.G., Tosti, M.E., Weimer, L.E., D’Angelo, F., Schiadà, L., Di , Leo, A., Contessi, G.B., De , Siena, M., Foschi, F.G., Dall’Aglio, A.C., Del , Pin, B., Zignego, A.L., Cela, E.M., Santantonio, T.A., Bruno, S.R., Alessandrini, A.I., Biagio, A., Nicolini, L.A., Rumi, M.G., D’Arminio , Monforte, A., D’Ambrosio, R., Pasetto, M.C., Buonomo, A.R., Amoruso, D.C., Saturnino, M.R., Gaeta, G.B., D’Adamo, G., Russo, F.P., Capitano, A.R., Craxì, A., Gizzi, M.C., Brunetto, M.R., D’Ettorre, G., Cavallari, E.N., Gebremeskel, T.S., D’Offizi, G., D’Aversa, F., Dell’Unto, C., Schimizzi, A.M., Saracco, G.M., Cosco, Alfredo, Dall’Aglio, A. C., Salomoni, Valentina, Nicolini, Elvira, Calvi, Marta, Soria, Giovanni, D'Adamo, Danilo, ALONSO ALBERTI, MARIA PALOMA CARMEN, Orlandini, Giovanni, DE ASTIS, Fabio, Sozio, Concetta, Terzini, Angelico, DE SIENA, ANDREA URIEL, Taliani, Sabrina, Spaziante, Agata, Lamonica, Emilia, and Capra, Carlo
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Liver Cirrhosis ,Pediatrics ,Time Factors ,Settore MED/09 - Medicina Interna ,National Health Programs ,ERADICATION ,OUTBREAK ,antiviral treatment, anti HCV, economic consequences ,Hepacivirus ,LIVER FIBROSIS ,Severity of Illness Index ,Health Services Accessibility ,COST-EFFECTIVENESS ,Indirect costs ,0302 clinical medicine ,Epidemiology ,virus infection ,030212 general & internal medicine ,health care economics and organizations ,cost effectiveness ,030503 health policy & services ,Health Policy ,Health services research ,health ,Hepatitis C ,Markov Chains ,chronic hepatitis C, virus infection, fibrosis progression, cost effectiveness, liver fibrosis ,Italy ,Pharmacology ,Public Health, Environmental and Occupational Health ,Cohort ,Settore SECS-P/03 - Scienza delle Finanze ,Disease Progression ,Public Health ,0305 other medical science ,Viral hepatitis ,Anti-HCV antiviral treatment ,CHRONIC HEPATITIS-C ,medicine.medical_specialty ,Genotype ,Settore MED/12 - GASTROENTEROLOGIA ,VIRUS-INFECTION ,Antiviral Agents ,NO ,03 medical and health sciences ,Cost Savings ,Humans ,medicine ,MANAGEMENT ,chronic hepatitis C ,INDUCED DISEASES ,METAANALYSIS ,Health economics ,business.industry ,Public health ,Environmental and Occupational Health ,medicine.disease ,FIBROSIS PROGRESSION ,business - Abstract
OBJECTIVE:\ud We estimated the cost consequence of Italian National Health System (NHS) investment in direct-acting antiviral (DAA) therapy according to hepatitis C virus (HCV) treatment access policies in Italy.\ud \ud METHODS:\ud A multistate, 20-year time horizon Markov model of HCV liver disease progression was developed. Fibrosis stage, age and genotype distributions were derived from the Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. The treatment efficacy, disease progression probabilities and direct costs in each health state were obtained from the literature. The break-even point in time (BPT) was defined as the period of time required for the cumulative costs saved to recover the Italian NHS investment in DAA treatment. Three different PITER enrolment periods, which covered the full DAA access evolution in Italy, were considered.\ud \ud RESULTS:\ud The disease stages of 2657 patients who consecutively underwent DAA therapy from January 2015 to December 2017 at 30 PITER clinical centres were standardized for 1000 patients. The investment in DAAs was considered to equal €25 million, €15 million, and €9 million in 2015, 2016, and 2017, respectively. For patients treated in 2015, the BPT was not achieved, because of the disease severity of the treated patients and high DAA prices. For 2016 and 2017, the estimated BPTs were 6.6 and 6.2 years, respectively. The total cost savings after 20 years were €50.13 and €55.50 million for 1000 patients treated in 2016 and 2017, respectively.\ud \ud CONCLUSIONS:\ud This study may be a useful tool for public decision makers to understand how HCV clinical and epidemiological profiles influence the economic burden of HCV.
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- 2019
171. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia
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Bellik, Lydia, Vinci, Maria Cristina, Filippi, Sandra, Ledda, Fabrizio, and Parenti, Astrid
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- 2005
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172. Peginterferon alfa-2b plus ribavirin for naïve patients with genotype 1 chronic hepatitis C: a randomized controlled trial
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Bruno, Savino, Cammà, Calogero, Di Marco, Vito, Rumi, Mariagrazia, Vinci, Maria, Camozzi, Mario, Rebucci, Chiara, Di Bona, Danilo, Colombo, Massimo, Craxì, Antonio, Mondelli, Mario U., and Pinzello, Giovanbattista
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- 2004
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173. Effect of vascular endothelial growth factor and epidermal growth factor on iatrogenic apoptosis in human endothelial cells
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Vinci, Maria Cristina, Visentin, Barbara, Cusinato, Federico, Nardelli, Giovanni Battista, Trevisi, Lucia, and Luciani, Sisto
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- 2004
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174. Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study
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Petta, Salvatore, Marzioni, Marco, Russo, Pierluigi, Aghemo, Alessio, Alberti, Alfredo, ASCIONE, ANTONIO, Antinori, Andrea, Bruno, Raffaele, Bruno, Savino, Chirianni, Antonio, Gaeta, Giovanni Battista, Giannini, Edoardo G, Merli, Manuela, Messina, Vincenzo, Montilla, Simona, Perno, Carlo Federico, Puoti, Massimo, Raimondo, Giovanni, Rendina, Maria, Silberstein, Francesca Ceccherini, Villa, Erica, Zignego, Anna Linda, Pani, Luca, Craxì, Antonio, Tabone, Marco, Andreoni, Massimo, Teti, Elisabetta, Angelico, Mario, Persico, Marcello, Masarone, Mario, Chiodera, Aledssandro, Solinas, Attilio, delle Monache, Marco, Cecere, Roberto, Maria Schimizzi, Anna, Piovesan, Sara, Campagnolo, Davide, Chiara Piras, Maria, Zolfino, Teresa, Paolo Russo, Francesca, Morelli, Olivia, Sangiovanni, Vincenzo, Onofrio, Mirella, Iodice, Valentina, Izzi, Antonio, Pirisi, Massimo, Danieli, Elena, Vinci, Maria, Rizzardini, Giuliano, Fagiuoli, Stefano, Pasulo, Luisa, D'Arminio Monforte, Antonella, Zuin, Massimo, Giorgini, Alessia, Simeone, Filomena, Piali, Guido, Lo Guercio, Carmela, Federico, Alessandro, Brancaccio, Giuseppina, Marrone, Aldo, Abbati, Giuseppe, Boarini, Chiara, Borghi, Vanni, Bernabucci, Veronica, Corti, Giampaolo, Monti, Monica, Rizzetto, Mario, Martini, Silvia, Andreone, Pietro, Gianstefani, Alice, Lenzi, Marco, Verucchi, Gabriella, Toniutto, Pierluigi, Borgia, Guglielmo, Caporaso, Nicola, Morisco, Filomena, Nardone, Gaetano, Angrisani, Debora, Giacometti, Andrea, Benedetti, Antonio, Tarantino, Giuseppe, Marsetti, Fabio, Tavio, Marcello, Novara, Sergio, Antonia Santantonio, Teresa, Serviddio, Gaetano, Brunetto, Maurizia, Coco, Barbara, Angarano, Gioacchino, Milella, Michele, BARONE, MICHELE, Di Leo, Alfredo, Ettore Sansonno, Domenico, Cacciola, Irene, Boffa, Nicola, Saracco, Giorgio, Di Biagio, Antonio, Picciotto, Antonino, de Luca, Andrea, Calvaruso, Vincenza, Corradori, Silvia, Ferrari, Carlo, Orlandini, Alessandra, Maida, Ivana, Torti, Carlo, Chessa, Luchino, Felder, Martina, Vespasiani Gentilucci, Umberto, Angeli, Paolo, Romano, Antonietta, Ludovico Rapaccini, Gian, Miele, Luca, Cima, Serena, Luisa Russo, Maria, Cozzolongo, Raffaele, Onnelli, Giovanna, D'Offizi, Giampiero, Lionetti, Raffaella, Montalbano, Marzia, Guerra, Michele, Di Perri, Giovanni, Boglione, Lucio, Capra, Franco, Carolo, Giada, Ieluzzi, Donatella, Antonini, Cinzia, Termite, Antonio, Madonia, Salvatore, Tarquini, Pierluigi, Parruti, Giustino, Vecchiet, Giacomo, Falasca, Katia, Menzaghi, Barbara, Quirino, Tiziana, Dentone, Chiara, Maria Piscaglia, Anna, Rossi, Cristina, Giordani, Maria, Fontanella, Luca, Cassola, Giovanni, Russello, Maurizio, Cristaudo, Antonio, Giacomet, Vania, Colombo, Massimo, Donato, Francesca, Durante, Emanuele, Cosco, Lucio, Marignani, Massimo, Quartini, Mariano, Memoli, Massimo, Ganga, Roberto, Ponti, Laura, Soria, Alessandro, Grazia Rumi, Maria, Gulminetti, Roberto, Maserati, Renato, Mondelli, Mario, Lazzarin, Adriano, Rita Parisi, Maria, Canovari, Benedetta, Avancini, Ivo, Pravadelli, Cecilia, Blanc, Pier, Pasquazzi, Caterina, Maria Mastroianni, Claudio, Lichtner, Myriam, Distefano, Marco, Magnani, Silvia, Paganin, Simona, Erne, Elke, Gatti, Pietro, Tundi, Paolo, Calabrese, Paolo, Gasbarrini, Antonio, Grieco, Antonio, Coppola, Nicola, Del Poggio, Paolo, Levrero, Massimo, Talliani, Gloria, Vullo, Vincenzo, Cauda, Roberto, La Monica, Silvia, Potenza, Domenico, Rizzo, Salvatore, Castelli, Francesco, Marie Pigozzi, Grazielle, Ciancio, Alessia, Romagnoli, Dante, Barchetti, Federica, Ivanovic, Jelena, Longo, Olimpia, Petraglia, Sandra, Paola Trotta, Maria, NARDONE, GERARDO ANTONIO PIO, Petta, Salvatore, Marzioni, Marco, Russo, Pierluigi, Aghemo, Alessio, Alberti, Alfredo, Ascione, Antonio, Antinori, Andrea, Bruno, Raffaele, Bruno, Savino, Chirianni, Antonio, Gaeta, Giovanni Battista, Giannini, Edoardo G, Merli, Manuela, Messina, Vincenzo, Montilla, Simona, Perno, Carlo Federico, Puoti, Massimo, Raimondo, Giovanni, Rendina, Maria, Silberstein, Francesca Ceccherini, Villa, Erica, Zignego, Anna Linda, Pani, Luca, Craxì, Antonio, Tabone, Marco, Andreoni, Massimo, Teti, Elisabetta, Angelico, Mario, Persico, Marcello, Masarone, Mario, Chiodera, Aledssandro, Solinas, Attilio, delle Monache, Marco, Cecere, Roberto, Maria Schimizzi, Anna, Piovesan, Sara, Campagnolo, Davide, Chiara Piras, Maria, Zolfino, Teresa, Paolo Russo, Francesca, Morelli, Olivia, Sangiovanni, Vincenzo, Onofrio, Mirella, Iodice, Valentina, Izzi, Antonio, Pirisi, Massimo, Danieli, Elena, Vinci, Maria, Rizzardini, Giuliano, Fagiuoli, Stefano, Pasulo, Luisa, D'Arminio Monforte, Antonella, Zuin, Massimo, Giorgini, Alessia, Simeone, Filomena, Piali, Guido, Lo Guercio, Carmela, Federico, Alessandro, Brancaccio, Giuseppina, Marrone, Aldo, Abbati, Giuseppe, Boarini, Chiara, Borghi, Vanni, Bernabucci, Veronica, Corti, Giampaolo, Monti, Monica, Rizzetto, Mario, Martini, Silvia, Andreone, Pietro, Gianstefani, Alice, Lenzi, Marco, Verucchi, Gabriella, Toniutto, Pierluigi, Borgia, Guglielmo, Caporaso, Nicola, Morisco, Filomena, Nardone, Gaetano, Angrisani, Debora, Giacometti, Andrea, Benedetti, Antonio, Tarantino, Giuseppe, Marsetti, Fabio, Tavio, Marcello, Novara, Sergio, Antonia Santantonio, Teresa, Serviddio, Gaetano, Brunetto, Maurizia, Coco, Barbara, Angarano, Gioacchino, Milella, Michele, Barone, Michele, Di Leo, Alfredo, Ettore Sansonno, Domenico, Cacciola, Irene, Boffa, Nicola, Saracco, Giorgio, Di Biagio, Antonio, Picciotto, Antonino, de Luca, Andrea, Calvaruso, Vincenza, Corradori, Silvia, Ferrari, Carlo, Orlandini, Alessandra, Maida, Ivana, Torti, Carlo, Chessa, Luchino, Felder, Martina, Vespasiani Gentilucci, Umberto, Angeli, Paolo, Romano, Antonietta, Ludovico Rapaccini, Gian, Miele, Luca, Cima, Serena, Luisa Russo, Maria, Cozzolongo, Raffaele, Onnelli, Giovanna, D'Offizi, Giampiero, Lionetti, Raffaella, Montalbano, Marzia, Guerra, Michele, Di Perri, Giovanni, Boglione, Lucio, Capra, Franco, Carolo, Giada, Ieluzzi, Donatella, Antonini, Cinzia, Termite, Antonio, Madonia, Salvatore, Tarquini, Pierluigi, Parruti, Giustino, Vecchiet, Giacomo, Falasca, Katia, Menzaghi, Barbara, Quirino, Tiziana, Dentone, Chiara, Maria Piscaglia, Anna, Rossi, Cristina, Giordani, Maria, Fontanella, Luca, Cassola, Giovanni, Russello, Maurizio, Cristaudo, Antonio, Giacomet, Vania, Colombo, Massimo, Donato, Francesca, Durante, Emanuele, Cosco, Lucio, Marignani, Massimo, Quartini, Mariano, Memoli, Massimo, Ganga, Roberto, Ponti, Laura, Soria, Alessandro, Grazia Rumi, Maria, Gulminetti, Roberto, Maserati, Renato, Mondelli, Mario, Lazzarin, Adriano, Rita Parisi, Maria, Canovari, Benedetta, Avancini, Ivo, Pravadelli, Cecilia, Blanc, Pier, Pasquazzi, Caterina, Maria Mastroianni, Claudio, Lichtner, Myriam, Distefano, Marco, Magnani, Silvia, Paganin, Simona, Erne, Elke, Gatti, Pietro, Tundi, Paolo, Calabrese, Paolo, Gasbarrini, Antonio, Grieco, Antonio, Coppola, Nicola, Del Poggio, Paolo, Levrero, Massimo, Talliani, Gloria, Vullo, Vincenzo, Cauda, Roberto, La Monica, Silvia, Potenza, Domenico, Rizzo, Salvatore, Castelli, Francesco, Marie Pigozzi, Grazielle, Ciancio, Alessia, Romagnoli, Dante, Barchetti, Federica, Ivanovic, Jelena, Longo, Olimpia, Petraglia, Sandra, Paola Trotta, Maria, Petta, S., Marzioni, M., Russo, P., Aghemo, A., Alberti, A., Ascione, A., Antinori, A., Bruno, R., Bruno, S., Chirianni, A., Gaeta, G., Giannini, E., Merli, M., Messina, V., Montilla, S., Perno, C., Puoti, M., Raimondo, G., Rendina, M., Silberstein, F., Villa, E., Zignego, A., Pani, L., Craxi, A., Tabone, M., Andreoni, M., Teti, E., Angelico, M., Persico, M., Masarone, M., Chiodera, A., Solinas, A., delle Monache, M., Cecere, R., Maria Schimizzi, A., Piovesan, S., Campagnolo, D., Chiara Piras, M., Zolfino, T., Paolo Russo, F., Morelli, O., Sangiovanni, V., Onofrio, M., Iodice, V., Izzi, A., Pirisi, M., Danieli, E., Vinci, M., Rizzardini, G., Fagiuoli, S., Pasulo, L., D'Arminio Monforte, A., Zuin, M., Giorgini, A., Simeone, F., Piali, G., Lo Guercio, C., Federico, A., Brancaccio, G., Marrone, A., Abbati, G., Boarini, C., Borghi, V., Bernabucci, V., Corti, G., Monti, M., Rizzetto, M., Martini, S., Andreone, P., Gianstefani, A., Lenzi, M., Verucchi, G., Toniutto, P., Borgia, G., Caporaso, N., Morisco, F., Nardone, G., Angrisani, D., Giacometti, A., Benedetti, A., Tarantino, G., Marsetti, F., Tavio, M., Novara, S., Antonia Santantonio, T., Serviddio, G., Brunetto, M., Coco, B., Angarano, G., Milella, M., Barone, M., Di Leo, A., Ettore Sansonno, D., Cacciola, I., Boffa, N., Saracco, G., Di Biagio, A., Picciotto, A., de Luca, A., Calvaruso, V., Corradori, S., Ferrari, C., Orlandini, A., Maida, I., Torti, C., Chessa, L., Felder, M., Vespasiani Gentilucci, U., Angeli, P., Romano, A., Ludovico Rapaccini, G., Miele, L., Cima, S., Luisa Russo, M., Cozzolongo, R., Onnelli, G., D'Offizi, G., Lionetti, R., Montalbano, M., Guerra, M., Di Perri, G., Boglione, L., Capra, F., Carolo, G., Ieluzzi, D., Antonini, C., Termite, A., Madonia, S., Tarquini, P., Parruti, G., Vecchiet, G., Falasca, K., Menzaghi, B., Quirino, T., Dentone, C., Maria Piscaglia, A., Rossi, C., Giordani, M., Fontanella, L., Cassola, G., Russello, M., Cristaudo, A., Giacomet, V., Colombo, M., Donato, F., Durante, E., Cosco, L., Marignani, M., Quartini, M., Memoli, M., Ganga, R., Ponti, L., Soria, A., Grazia Rumi, M., Gulminetti, R., Maserati, R., Mondelli, M., Lazzarin, A., Rita Parisi, M., Canovari, B., Avancini, I., Pravadelli, C., Blanc, P., Pasquazzi, C., Maria Mastroianni, C., Lichtner, M., Distefano, M., Magnani, S., Paganin, S., Erne, E., Gatti, P., Tundi, P., Calabrese, P., Gasbarrini, A., Grieco, A., Coppola, N., Del Poggio, P., Levrero, M., Talliani, G., Vullo, V., Cauda, R., La Monica, S., Potenza, D., Rizzo, S., Castelli, F., Marie Pigozzi, G., Ciancio, A., Romagnoli, D., Barchetti, F., Ivanovic, J., Longo, O., Petraglia, S., Paola Trotta, M., Savino, Bruno, Nardone, GERARDO ANTONIO PIO, Petta, S, Marzioni, M, Russo, P, Aghemo, A, Alberti, A, Ascione, A, Antinori, A, Bruno, R, Bruno, S, Chirianni, A, Gaeta, G, Giannini, E, Merli, M, Messina, V, Montilla, S, Perno, C, Puoti, M, Raimondo, G, Rendina, M, Silberstein, F, Villa, E, Zignego, A, Pani, L, Craxì, A, and Fagiuoli, S
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Cyclopropanes ,Compassionate Use Trials ,Liver Cirrhosis ,Male ,chemistry.chemical_compound ,0302 clinical medicine ,2-Naphthylamine ,HCV, direct-acting antiviral, mixed cryoglobulinemia, RBV ,Anilides ,030212 general & internal medicine ,Longitudinal Studies ,Prospective Studies ,Chronic ,Adult ,Aged ,Antiviral Agents ,Carbamates ,Drug Therapy, Combination ,Female ,Genotype ,Hepatitis C, Chronic ,Humans ,Macrocyclic Compounds ,Middle Aged ,Ribavirin ,Ritonavir ,Sulfonamides ,Treatment Outcome ,Uracil ,Settore MED/12 - Gastroenterologia ,Dasabuvir ,HCV DAA ,Gastroenterology ,virus diseases ,Valine ,Settore MED/07 - Microbiologia e Microbiologia Clinica ,Hepatitis C ,Hepatology ,Combination ,030211 gastroenterology & hepatology ,medicine.drug ,medicine.medical_specialty ,Proline ,Lactams, Macrocyclic ,Hepatitis C virus genotype 1, Hepatitis C virus genotype 4, decompensated liver cirrhosis, antiviral therapy, dasabuvir, ombitasvir, paritaprevir ,03 medical and health sciences ,Drug Therapy ,Internal medicine ,medicine ,Decompensation ,Adverse effect ,business.industry ,Virology ,Ombitasvir ,Clinical trial ,chemistry ,Paritaprevir ,business - Abstract
Summary Background We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decompensation while approval of these regimens was pending in Italy. Methods In this prospective observational study, we collected data from a compassionate use nationwide programme from March 17, 2014, to May 28, 2015. Patients with HCV genotype 1 infection and cirrhosis at high risk of decompensation were given coformulated ombitasvir (25 mg), paritaprevir (150 mg), and ritonavir (100 mg) once daily and dasabuvir (250 mg) twice daily for 12 weeks (patients with HCV genotype 1b infection) or 24 weeks (patients with HCV genotype 1a infection). Patients with HCV genotype 4 infection were given coformulated ombitasvir (25 mg), paritaprevir (150 mg), and ritonavir (100 mg) once per day for 24 weeks. All patients were given weight-based ribavirin. The primary efficacy endpoint was sustained virological response at week 12 after the end of treatment (SVR12), analysed by intention-to-treat. Univariate and multivariate logistic regression analyses were used to identify baseline characteristics associated with SVR12. Adverse events were recorded throughout the study. Findings 728 (96%) of 762 patients with cirrhosis who were given ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin therapy for 12 or 24 weeks achieved SVR12. Logistic regression analyses identified that bilirubin concentrations of less than 2 mg/dL were associated with SVR12 (odds ratio [OR] 4·76 [95% CI 1·83–12·3]; p=0·001). 166 (23%) of 734 patients included in safety analyses had an adverse event. 25 (3%) patients discontinued treatment because of adverse events. Asthenia was the most commonly reported adverse event, occurring in 36 (5%) patients. Interpretation Our findings suggest that the safety and effectiveness of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin in patients with HCV genotype 1 or 4 infection and cirrhosis at high risk of decompensation in a real-life setting are similar to those reported in clinical trials. The concordance with clinical trials provides reassurance that the reported efficacy of this treatment in clinical trials will translate to its use in routine clinical practice. Funding Dipartimento Biomedico di Medicina Interna e Specialistica dell'Universita di Palermo.
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- 2017
175. Modelling cost-effectiveness and health gains of a 'universal' vs. 'prioritized' HCV treatment policy in a real-life cohort
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Kondili, Loreta A, Romano, Federica, Rolli, Francesca Romana, Ruggeri, Matteo, Rosato, Stefano, Brunetto, Maurizia Rossana, Zignego, Anna Linda, Ciancio, Alessia, Di Leo, Alfredo, Raimondo, Giovanni, Ferrari, Carlo, Taliani, Gloria, Borgia, Guglielmo, Santantonio, Teresa Antonia, Blanc, Pierluigi, GAETA, Giovanni Battista, Gasbarrini, Antonio, Chessa, Luchino, Erne, Elke Maria, Villa, Erica, Ieluzzi, Donatella, Russo, Francesco Paolo, Andreone, Pietro, Vinci, Maria, Coppola, Carmine, Chemello, Liliana, Madonia, Salvatore, Verucchi, Gabriella, Persico, Marcello, Zuin, Massimo, Puoti, Massimo, Alberti, Alfredo, Nardone, Gerardo, Massari, Marco, Montalto, Giuseppe, Foti, Giuseppe, Rumi, Maria Grazia, Quaranta, Maria Giovanna, Cicchetti, Americo, Craxì, Antonio, Vella, Stefano, PITER Collaborating Group, FEDERICO, Alessandro, Dallio M, LOGUERCIO, Carmelina, Kondili, Loreta A, Romano, Federica, Rolli, Francesca Romana, Ruggeri, Matteo, Rosato, Stefano, Brunetto, Maurizia Rossana, Zignego, Anna Linda, Ciancio, Alessia, Di Leo, Alfredo, Raimondo, Giovanni, Ferrari, Carlo, Taliani, Gloria, Borgia, Guglielmo, Santantonio, Teresa Antonia, Blanc, Pierluigi, Gaeta, Giovanni Battista, Gasbarrini, Antonio, Chessa, Luchino, Erne, Elke Maria, Villa, Erica, Ieluzzi, Donatella, Russo, Francesco Paolo, Andreone, Pietro, Vinci, Maria, Coppola, Carmine, Chemello, Liliana, Madonia, Salvatore, Verucchi, Gabriella, Persico, Marcello, Zuin, Massimo, Puoti, Massimo, Alberti, Alfredo, Nardone, Gerardo, Massari, Marco, Montalto, Giuseppe, Foti, Giuseppe, Rumi, Maria Grazia, Quaranta, Maria Giovanna, Cicchetti, Americo, Craxì, Antonio, Vella, Stefano, PITER Collaborating, Group, Federico, Alessandro, Dallio, M, and Loguercio, Carmelina
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real-life cohort ,HCV ,antiviral therapy ,cost-effectivene ,Hepatitis C - Abstract
We evaluated the cost-effectiveness of two alternative DAA treatment policies in a real-life cohort of HCV-infected patients: Policy 1 - "universal": treat all patients, regardless of the fibrosis stage; Policy 2 - treat only "prioritized" patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and healthcare system perspective, was applied to the PITER cohort (representative of Italian HCV-infected patients in care). Specifically, 8,125 patients naïve to DAA treatment, without clinical, sociodemographic or insurance restrictions was used to evaluate the policies' cost-effectiveness. The patients' age, fibrosis stage, assumed DAA treatment cost of €15,000/patient and the Italian liver disease costs were used to evaluate Quality-Adjusted Life-Years (QALY) This article is protected by copyright. All rights reserved.
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- 2017
176. Autografting Followed by Nonmyeloablative Immunosuppressive Chemotherapy and Allogeneic Peripheral-Blood Hematopoietic Stem-Cell Transplantation as Treatment of Resistant Hodgkin’s Disease and Non-Hodgkin’s Lymphoma
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Carella, Angelo M., Cavaliere, Marina, Lerma, Enrica, Ferrara, Raimondo, Tedeschi, Lucilla, Romanelli, Antonella, Vinci, Maria, Pinotti, Graziella, Lambelet, Paola, Loni, Carlo, Verdiani, Simonetta, De Stefano, Francesco, Valbonesi, Mauro, and Corsetti, Maria Teresa
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- 2000
177. Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
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Vinci Maria, Gowan Sharon, Boxall Frances, Patterson Lisa, Zimmermann Miriam, Court William, Lomas Cara, Mendiola Marta, Hardisson David, and Eccles Suzanne A
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3D ,angiogenesis ,drug response ,high throughput ,invasion ,migration ,tumor spheroids ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect to gene expression profiles, signaling pathway activity and drug sensitivity. However, most currently available three-dimensional techniques are time consuming and/or lack reproducibility; thus standardized and rapid protocols are urgently needed. Results To address this requirement, we have developed a versatile toolkit of reproducible three-dimensional tumor spheroid models for dynamic, automated, quantitative imaging and analysis that are compatible with routine high-throughput preclinical studies. Not only do these microplate methods measure three-dimensional tumor growth, but they have also been significantly enhanced to facilitate a range of functional assays exemplifying additional key hallmarks of cancer, namely cell motility and matrix invasion. Moreover, mutual tissue invasion and angiogenesis is accommodated by coculturing tumor spheroids with murine embryoid bodies within which angiogenic differentiation occurs. Highly malignant human tumor cells were selected to exemplify therapeutic effects of three specific molecularly-targeted agents: PI-103 (phosphatidylinositol-3-kinase (PI3K)-mammalian target of rapamycin (mTOR) inhibitor), 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) (heat shock protein 90 (HSP90) inhibitor) and CCT130234 (in-house phospholipase C (PLC)γ inhibitor). Fully automated analysis using a Celigo cytometer was validated for tumor spheroid growth and invasion against standard image analysis techniques, with excellent reproducibility and significantly increased throughput. In addition, we discovered key differential sensitivities to targeted agents between two-dimensional and three-dimensional cultures, and also demonstrated enhanced potency of some agents against cell migration/invasion compared with proliferation, suggesting their preferential utility in metastatic disease. Conclusions We have established and validated a suite of highly reproducible tumor microplate three-dimensional functional assays to enhance the biological relevance of early preclinical cancer studies. We believe these assays will increase the translational predictive value of in vitro drug evaluation studies and reduce the need for in vivo studies by more effective triaging of compounds.
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- 2012
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178. FAP heterogeneity: important functional feature or experimental noise?
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Giuliani, Giulio, Fuoco, Claudia, Petrilli, Lucia Lisa, Marinkovic, Milica, Giorda, Ezio, Vinci, Maria, Castagnoli, Luisa, and Cesareni, Gianni
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- 2018
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179. A Case of Beriberi in a young patient: take advantage of clinical and laboratory clues
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Malandrino, Danilo, Vitiello, Gianfranco, Marzio, Giulia Di, Vinci, Maria Costanza, Vannini, Francesco, and Poggesi, Loredana
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- 2018
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180. Author response: Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin
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Stowe, Cassandra L, primary, Burley, Thomas A, additional, Allan, Helen, additional, Vinci, Maria, additional, Kramer-Marek, Gabriela, additional, Ciobota, Daniela M, additional, Parkinson, Gary N, additional, Southworth, Tara L, additional, Agliardi, Giulia, additional, Hotblack, Alastair, additional, Lythgoe, Mark F, additional, Branchini, Bruce R, additional, Kalber, Tammy L, additional, Anderson, James C, additional, and Pule, Martin A, additional
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- 2019
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181. SAT0460 HCV-RELATED MIXED CRYOGLOBULINAEMIA IN THE DIRECT-ANTIVIRAL AGENTS ERA: IS THERE ADVANTAGE IN SEQUENTIAL THERAPY WITH RITUXIMAB?
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Cicco, Maria Di, primary, Filippini, Davide Antonio, additional, Filippini, Federica, additional, Belloli, Laura, additional, Campanella, Valeria, additional, Casu, Cinzia, additional, Chevallard, Michel, additional, Muscarà, Marina, additional, Romano, Mariaeva, additional, Schito, Emanuela, additional, Verduci, Elisa, additional, Puoti, Massimo, additional, Vinci, Maria, additional, and Epis, Oscar Massimiliano, additional
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- 2019
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182. 486-P: Hyperglycemia Promotes Epigenetic Priming of RELA/p65 Gene in Cord Blood-Derived CD34+ Stem Cells and Their Differentiation into Proinflammatory CD16 Myeloid Cell Population
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VINCI, MARIA CRISTINA, primary, VIGORELLI, VERA, additional, GENOVESE, STEFANO, additional, and POMPILIO, GIULIO, additional
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- 2019
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183. Abnormal DNA Methylation Induced by Hyperglycemia Reduces CXCR4 Gene Expression in CD34 + Stem Cells
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Vigorelli, Vera, primary, Resta, Jessica, additional, Bianchessi, Valentina, additional, Lauri, Andrea, additional, Bassetti, Beatrice, additional, Agrifoglio, Marco, additional, Pesce, Maurizio, additional, Polvani, Gianluca, additional, Bonalumi, Giorgia, additional, Cavallotti, Laura, additional, Alamanni, Francesco, additional, Genovese, Stefano, additional, Pompilio, Giulio, additional, and Vinci, Maria Cristina, additional
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- 2019
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184. Direct Involvement of Cranial Nerve V at Diagnosis in Patients With Diffuse Intrinsic Pontine Glioma: A Potential Magnetic Resonance Predictor of Short-Term Survival
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Colafati, Giovanna Stefania, primary, Voicu, Ioan Paul, additional, Carducci, Chiara, additional, Caulo, Massimo, additional, Vinci, Maria, additional, Diomedi-Camassei, Francesca, additional, Merli, Pietro, additional, Carai, Andrea, additional, Miele, Evelina, additional, Cacchione, Antonella, additional, Tomà, Paolo, additional, Locatelli, Franco, additional, and Mastronuzzi, Angela, additional
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- 2019
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185. THU-141-Efficacy and safety of elbasvir/grazoprevir in a large real-life cohort of HCV-infected patients
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Gambato, Martina, primary, Spinetti, Angiola, additional, Pasulo, Luisa, additional, D’ambrosio, Roberta, additional, Puoti, Massimo, additional, Schiavini, Monica, additional, Fabris, Paolo, additional, Sacchi, Paolo, additional, Gulminetti, Roberto, additional, Carolo, Giada, additional, Scotton, Piergiorgio, additional, Pozzan, Caterina, additional, Vinci, Maria, additional, Viganò, Mauro, additional, Lobello, Salvatore, additional, Zuin, Massimo Giovanni, additional, Aghemo, Alessio, additional, Rumi, Maria Grazia, additional, Carrara, Maurizio, additional, Manfrin, Vinicio, additional, Uberti-Foppa, Caterina, additional, Panese, Sandro, additional, Cattelan, Francesca, additional, Paon, Veronica, additional, Pan, Angelo, additional, Spinelli, Ombretta, additional, Monforte, Antonella d'Arminio, additional, Colli, Agostino, additional, Spinzi, Giancarlo, additional, Russo, Francesco Paolo, additional, Chemello, Liliana, additional, Vincenzi, Valter, additional, Grossi, Paolo Antonio, additional, Buscarini, Elisabetta, additional, Cardaci, Giovanna, additional, Soria, Alessandro, additional, Menzaghi, Barbara, additional, Mendeni, Monia, additional, Degasperi, Elisabetta, additional, Soffredini, Roberta, additional, Colpani, Maria, additional, Comi, Laura, additional, Zuccaro, Valentina, additional, Zaltron, Serena, additional, Gori, ANDREA, additional, Poggio, Paolo Del, additional, Giorgini, Alessia, additional, Capretti, Andrea, additional, Memoli, massimo, additional, Pigozzi, Marie Graciella, additional, Rossi, Maria Cristina, additional, Cavalletto, Luisa, additional, Capra, Franco, additional, Colombo, Alberto, additional, Dibenedetto, Clara, additional, Landonio, Simona, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, Castelli, Francesco, additional, Alberti, Alfredo, additional, and Fagiuoli, Stefano, additional
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- 2019
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186. THU-128-Renal safety in 3,264 HCV patients treated with DAA-based regimens: Results from a large Italian real-life study
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D’ambrosio, Roberta, primary, Pasulo, Luisa, additional, Giorgini, Alessia, additional, Spinetti, Angiola, additional, Uberti-Foppa, Caterina, additional, Fanetti, Ilaria, additional, Puoti, Massimo, additional, Aghemo, Alessio, additional, Viganò, Paolo, additional, Vinci, Maria, additional, Menzaghi, Barbara, additional, Lombardi, Andrea, additional, Pan, Angelo, additional, Pigozzi, Marie Graciella, additional, Grossi, Paolo Antonio, additional, Lazzaroni, Sergio, additional, Spinelli, Ombretta, additional, Invernizzi, Pietro, additional, Maggiolo, Franco, additional, Colli, Agostino, additional, Molteni, Chiara, additional, Terreni, Natalia, additional, Monforte, Antonella d’Arminio, additional, Poggio, Paolo Del, additional, Taddei, Maria Teresa, additional, Colombo, Silvia, additional, Brocchieri, Alessandra, additional, Bhoori, Sherrie, additional, Buscarini, Elisabetta, additional, Centenaro, Riccardo, additional, Mendeni, Monia, additional, Colombo, Alberto, additional, Marco, Mariella Di, additional, Dionigi, Elena, additional, Bella, Daniele, additional, Borghi, Marta, additional, Zuin, Massimo Giovanni, additional, Zaltron, Serena, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, and Fagiuoli, Stefano, additional
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- 2019
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187. THU-166-Treatment of 320 genotype 3 cirrhotic patients with 12 weeks of sofosbuvir/velpatasvir with or without ribavirin: Real life experience from Italy
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Pasulo, Luisa, primary, Gambato, Martina, additional, Spinetti, Angiola, additional, D’ambrosio, Roberta, additional, Puoti, Massimo, additional, Ciancio, Alessia, additional, Marco, Vito Di, additional, Calvaruso, Vincenza, additional, Piero, Colombatto, additional, Brunetto, Maurizia, additional, Schiavini, Monica, additional, Sacchi, Paolo, additional, Gulminetti, Roberto, additional, Carolo, Giada, additional, Scotton, Piergiorgio, additional, Pozzan, Caterina, additional, Vinci, Maria, additional, Vigano, Mauro, additional, Lombardi, Andrea, additional, Lobello, Salvatore, additional, Zuin, Massimo Giovanni, additional, Aghemo, Alessio, additional, Rumi, Maria Grazia, additional, Manfrin, Vinicio, additional, Uberti-Foppa, Caterina, additional, Panese, Sandro, additional, Paon, Veronica, additional, Pan, Angelo, additional, Spinelli, Ombretta, additional, Monforte, Antonella d’Arminio, additional, Colli, Agostino, additional, Spinzi, Giancarlo, additional, Russo, Francesco Paolo, additional, Chemello, Liliana, additional, Vincenzi, Valter, additional, Grossi, Paolo Antonio, additional, Buscarini, Elisabetta, additional, Soria, Alessandro, additional, Menzaghi, Barbara, additional, Mendeni, Monia, additional, Soffredini, Roberta, additional, Colpani, Maria, additional, Zaltron, Serena, additional, Gori, ANDREA, additional, Giorgini, Alessia, additional, Cologni, Giuliana, additional, Cartabellotta, Fabio, additional, Difrancesco, Lorenzo, additional, Cacciola, Irene, additional, Albanese, Antonio, additional, Rosolini, Maria Antonietta Di, additional, Giacomo, Antonio Di, additional, Capretti, Andrea, additional, Memoli, massimo, additional, Cavalletto, Luisa, additional, Capra, Franco, additional, Colombo, Alberto, additional, Dibenedetto, Clara, additional, Magni, Carlo Federico, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, Castelli, Francesco, additional, Alberti, Alfredo, additional, and Fagiuoli, Stefano, additional
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- 2019
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188. THU-131-Effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir for retreatment of chronic hepatitis C patients with a previous failure to direct-acting antivirals: A real-life study from the NAVIGATORE Lombardia and Veneto Networks
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Degasperi, Elisabetta, primary, Spinetti, Angiola, additional, Lombardi, Andrea, additional, Landonio, Simona, additional, Scotton, Pier Giorgio, additional, Pasulo, Luisa, additional, Carlotto, Antonio, additional, Giorgini, Alessia, additional, Pozzoni, Pietro, additional, Angeli, Paolo, additional, Carrara, Maurizio, additional, Puoti, Massimo, additional, Gatti, Federico, additional, Carolo, Giada, additional, Vinci, Maria, additional, Zoncada, Alessia, additional, Bonfanti, Paolo, additional, Aghemo, Alessio, additional, Soria, Alessandro, additional, Centenaro, Riccardo, additional, Maggiolo, Franco, additional, Russo, Francesco Paolo, additional, Rovere, Pierangelo, additional, Piovesan, Sara, additional, Capra, Franco, additional, Viviani, Filippo, additional, Morini, Lorenzo, additional, Soffredini, Roberta, additional, Carriero, Canio, additional, Paolucci, Stefania, additional, Noventa, Franco, additional, Alberti, Alfredo, additional, Lampertico, Pietro, additional, and Fagiuoli, Stefano, additional
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- 2019
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189. THU-180-Treatment of genotype 3 HCV infection in the large real-life “Navigatore Lombardia” multicentre cohort: Results from three different regimens
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Soria, Alessandro, primary, Lapadula, Giuseppe, additional, Colella, Elisa, additional, Gambaro, Alessandra, additional, Spolti, Anna, additional, Bottalico, Nunzia, additional, Pasulo, Luisa, additional, Carderi, Isabella, additional, Lazzaroni, Sergio, additional, Boldizzoni, Roberto, additional, Scabeni, Luciana, additional, Poggio, Paolo Del, additional, Mels, Guido Colloredo, additional, Marco, Mariella Di, additional, Colombo, Alberto, additional, Grasso, Valentina, additional, Spinelli, Ombretta, additional, Pigozzi, Marie Graciella, additional, Graffeo, Massimo, additional, Spinetti, Angiola, additional, Carriero, Canio, additional, Menzaghi, Barbara, additional, Terreni, Natalia, additional, Brambilla, Paola, additional, Pan, Angelo, additional, Bella, Daniele, additional, Liani, Cecilia, additional, Polo, Silvia, additional, Aimo, Gianpiero, additional, Bhoori, Sherrie, additional, Bonfanti, Paolo, additional, Molteni, Chiara, additional, Gatti, Federico, additional, Viganò, Paolo, additional, Dionigi, Elena, additional, Centenaro, Riccardo, additional, Vinci, Maria, additional, Puoti, Massimo, additional, Borghi, Marta, additional, D’ambrosio, Roberta, additional, Degasperi, Elisabetta, additional, Soffredini, Roberta, additional, Valenti, Luca, additional, Gulminetti, Roberto, additional, Lombardi, Andrea, additional, Schiavini, Monica, additional, Landonio, Simona, additional, Rizzardini, Giuliano, additional, Capretti, Andrea, additional, Rumi, Maria Grazia, additional, Viganò, Mauro, additional, Giorgini, Alessia, additional, Merlini, Esther, additional, Bona, Anna De, additional, Monforte, Antonella D’arminio, additional, Uberti-Foppa, Caterina, additional, Hasson, Hamid, additional, Salpietro, Stefania, additional, Grossi, Paolo Antonio, additional, Aghemo, Alessio, additional, Gritti, Sara, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, and Fagiuoli, Stefano, additional
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- 2019
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190. Effectiveness and safety of sofosbuvir-based direct-acting antiviral combinations in HCV-2 and HCV-3 kidney transplant recipients
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D’Ambrosio, Roberta, primary, Vinci, Maria, additional, Franchina, Marianna, additional, Parlati, Lucia, additional, Zaltron, Serena, additional, Pasulo, Luisa, additional, Campise, Mariarosaria, additional, Messa, Piergiorgio, additional, Pol, Stanislas, additional, and Lampertico, Pietro, additional
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- 2019
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191. Seasonal influenza vaccination and absenteeism in health-care workers in two subsequent influenza seasons (2016/17 and 2017/18) in an Italian pediatric hospital
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Zaffina, Salvatore, primary, Gilardi, Francesco, additional, Rizzo, Caterina, additional, Sannino, Serena, additional, Brugaletta, Rita, additional, Santoro, Annapaola, additional, Castelli Gattinara, Guido, additional, Ciofi degli Atti, Marta Luisa, additional, Raponi, Massimiliano, additional, and Vinci, Maria Rosaria, additional
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- 2019
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192. Painted marks at El Mèdol quarry near Tarragona: observations on the logistics and organisation of a Roman limestone quarry
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Vinci, Maria Serena, primary
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- 2019
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193. High prevalence of acute onset autoimmune hepatitis in males: A real-life cohort from Northern Italy
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Donato, Maria Francesca, primary, Rigamonti, Cristina, additional, Monico, Sara, additional, Vinci, Maria, additional, Colapietro, Francesca, additional, del Poggio, Paolo, additional, and Colloredo, Guido, additional
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- 2019
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194. Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
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Tsoli, Maria, primary, Shen, Han, additional, Mayoh, Chelsea, additional, Franshaw, Laura, additional, Ehteda, Anahid, additional, Upton, Dannielle, additional, Carvalho, Diana, additional, Vinci, Maria, additional, Meel, Michael H., additional, van Vuurden, Dannis, additional, Plessier, Alexandre, additional, Castel, David, additional, Drissi, Rachid, additional, Farrell, Michael, additional, Cryan, Jane, additional, Crimmins, Darach, additional, Caird, John, additional, Pears, Jane, additional, Francis, Stephanie, additional, Ludlow, Louise E. A., additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, Liu, Bing, additional, Hansford, Jordan, additional, Gottardo, Nicholas G., additional, Hassall, Tim, additional, Kirby, Maria, additional, Fouladi, Maryam, additional, Hawkins, Cynthia, additional, Monje, Michelle, additional, Grill, Jacques, additional, Jones, Chris, additional, Hulleman, Esther, additional, and Ziegler, David S., additional
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- 2018
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195. International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
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Tsoli, Maria, primary, Shen, Han, additional, Mayoh, Chelsea, additional, Franshaw, Laura, additional, Ehteda, Anahid, additional, Upton, Danielle, additional, Carvalho, Diana, additional, Vinci, Maria, additional, Meel, Michael H., additional, van Vuurden, Dannis, additional, Plessier, Alexander, additional, Castel, David, additional, Drissi, Rachid, additional, Farrell, Michael, additional, Cryan, Jane, additional, Crimmins, Darach, additional, Caird, John, additional, Pears, Jane, additional, Francis, Stephanie, additional, Ludlow, Louise E. A., additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, Liu, Bing, additional, Hansford, Jordan, additional, Gottardo, Nick, additional, Hassall, Tim, additional, Kirby, Maria, additional, Fouladi, Maryam, additional, Hawkins, Cynthia, additional, Monje, Michelle, additional, Grill, Jacques, additional, Jones, Chris, additional, Hulleman, Esther, additional, and Ziegler, David S., additional
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- 2018
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196. PDTM-33. ATRX LOSS CONFERS ENHANCED SENSITIVITY TO COMBINED PARP INHIBITION AND RADIOTHERAPY IN PAEDIATRIC GLIOBLASTOMA MODELS
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Fazal Salom, Janat, primary, Bjerke, Lynn, additional, Carvalho, Diana, additional, Boult, Jessica, additional, Mackay, Alan, additional, Pemberton, Helen, additional, Molinari, Valeria, additional, Clarke, Matthew, additional, Vinci, Maria, additional, Carceller, Fernando, additional, Marshall, Lynley, additional, Moore, Andrew, additional, Montero Carcaboso, Angel, additional, Lord, Chris, additional, Robinson, Simon, additional, Hargrave, Darren, additional, and Jones, Chris, additional
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- 2018
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197. PDTM-31. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG
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Mackay, Alan, primary, Carvalho, Diana, additional, Molinari, Valeria, additional, Pemberton, Helen, additional, Temelso, Sara, additional, Burford, Anna, additional, Clarke, Matthew, additional, Fofana, Mariama, additional, Boult, Jessica, additional, Izquierdo, Elisa, additional, Taylor, Katy, additional, Bjerke, Lynn, additional, Fazal Salom, Janat, additional, Kessler, Ketty, additional, Rogers, Rebecca, additional, Marshall, Lynley, additional, Carceller, Fernando, additional, Pears, Jane, additional, Moore, Andrew, additional, Miele, Evelina, additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, Robinson, Simon, additional, Lord, Chris, additional, Olaciregui, Nagore, additional, Mora, Jaume, additional, Montero Carcaboso, Angel, additional, Hargrave, Darren, additional, Vinci, Maria, additional, and Jones, Chris, additional
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- 2018
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198. PDTM-09. DIFFUSE INTRINSIC PONTINE GLIOMA AND PEDIATRIC GLIOBLASTOMA DERIVED-EXOSOMES HAVE SPECIFIC ONCOGENIC SIGNATURES
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Pericoli, Giulia, primary, Galardi, Angela, additional, Lisa Petrilli, Lucia, additional, Colletti, Marta, additional, Ferretti, Roberta, additional, Paolini, Alessandro, additional, Masotti, Andrea, additional, Levi Mortera, Stefano, additional, Petrini, Stefania, additional, de Billy, Emmanuel, additional, Pascucci, Luisa, additional, Court, Will, additional, Cacchione, Antonella, additional, Carai, Andrea, additional, Diomedi Camassei, Francesca, additional, Moore, Andrew, additional, Montero Carcaboso, Angel, additional, Jones, Chris, additional, Mastronuzzi, Angela, additional, Locatelli, Franco, additional, Di Giannatale, Angela, additional, and Vinci, Maria, additional
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- 2018
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199. PDTM-34. TARGETING H3.3G34R/V RE-WIRING OF THE EPIGENOME IN PAEDIATRIC GLIOBLASTOMA OF CHILDREN AND YOUNG ADULTS
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Bjerke, Lynn, primary, Mackay, Alan, additional, Carvalho, Diana, additional, Pemberton, Helen, additional, Molinari, Valeria, additional, Vinci, Maria, additional, Carceller, Fernando, additional, Marshall, Lynley, additional, Moore, Andrew, additional, Montero Carcaboso, Angel, additional, Lord, Chris, additional, Hargrave, Darren, additional, and Jones, Chris, additional
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- 2018
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200. Chronic hepatitis B virus infection in Italy during the twenty-first century: an updated survey in 2019.
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Stroffolini, Tommaso, Ciancio, Alessia, Furlan, Caterina, Vinci, Maria, Niro, Grazia Anna, Russello, Maurizio, Colloredo, Guido, Morisco, Filomena, Coppola, Nicola, Babudieri, Sergio, Ferrigno, Luigina, Sagnelli, Caterina, Sagnelli, Evangelista, Collaborating group, Verzon, Giulia, Latanza, Arianna, Picciotto, Viviana, Fontana, Rosanna, Benigno, Rosa Grazia, and Pontillo, Giuseppina
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HEPATITIS B virus ,VIRUS diseases ,TWENTY-first century ,MULTIPLE regression analysis ,LOGISTIC regression analysis ,DRUG carriers - Abstract
The aim of this study is to provide updates on the characteristics of chronic HBsAg carriers in Italy before the advent of new drugs eliminating or functionally inactivating the genome HBV reservoirs. HBV endemicity has greatly decreased in Italy over the past decades. A not negligible number of chronic HBsAg carriers are still alive in the country. Chronic HBsAg carriers consecutively referring to 9 units in Italy were prospectively enrolled for a 6-month period in 2019. Multiple logistic regression analysis was performed to identify independent predictors of treatment. A total of 894 cases was recruited (sex ratio 1.6; mean age 53.7 ± 13.5 years). The proportion of subjects born abroad was 19.0%; only 1% of cases reported current heavy alcohol intake (> 4 units/day). Chronic HBV infection, chronic HBV hepatitis, and subjects with liver cirrhosis and/or HCC represented 24.8%, 55%, and 19.3% of cases, respectively. After exclusion of the 222 subjects with chronic HBV infection, the proportion of subjects under therapy was as high as 89.3%. A more severe liver disease (OR 2.52; 95% CI = 1.25–5.14) resulted an independent predictor of the likelihood of treatment; male sex was marginally associated (OR 1.67; 95% CI = 1.02–2.76) to the chance of treatment. People born abroad had same chance than Italians native to be treated (OR 2.12; 95% CI = 0.9–4.97). The high proportion of subjects under treatment and the absence of gender and ethnic barrier against treatment sound good news. These updated figures may represent reference data for evaluating the potential impact of forthcoming new therapy against HBV-related disease. [ABSTRACT FROM AUTHOR]
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- 2021
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