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994 results on '"Vigneri R"'

164. Risk factors for congenital hypothyroidism: results of a population case-control study

Author

Medda, E, Olivieri, A, Stazi, Ma, Grandolfo, Me, Fazzini, C, Baserga, M, Burroni, M, Cacciari, E, Calaciura, F, Cassio, A, Chiovato, L, Costa, Pietro, Leonardi, D, Martucci, M, Moschini, L, Pagliardini, S, Parlato, G, Pignero, A, Pinchera, A, Sala, D, Sava, L, Stoppioni, V, Tancredi, F, Valentini, F, Vigneri, R, and Sorcini, M.

Published
2005

189. p73 tumor-suppressor activity is impaired in human thyroid cancer

Author

Frasca, Francesco, Vella, V, Aloisi, A, Mandarino, A, Mazzon, E, Vigneri, R, Vigneri, Paolo, and Vella, Veronica

Subjects
Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Cell Cycle, Down-Regulation, Nuclear Proteins, Apoptosis, Cell Differentiation, Tumor Protein p73, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Cell Line, Tumor, Mutation, Humans, Genes, Tumor Suppressor, RNA, Messenger, Thyroid Neoplasms, Tumor Suppressor Protein p53
Abstract

The p73 protein is a member of the p53 family and, like p53, can induce cell-cycle arrest and apoptosis in response to DNA damage. Because the loss of p53 function is responsible for the progression of well-differentiated thyroid cancer to more aggressive phenotypes, we hypothesized that p73 might also be involved in thyroid carcinogenesis. We find that normal thyrocites do not express p73, whereas most thyroid malignancies are positive for p73 expression. However, the p73 protein of thyroid cancer cells is unresponsive to DNA-damaging agents, failing to elicit a block of the cell cycle or an apoptotic response. Notably, overexpression of transcriptionally active p73 in thyroid cancer lines can arrest the cell cycle but is still unable to induce cell death. The loss of p73 biological activity in neoplastic thyroid cells is partly explained by its interaction with transcriptionally inactive variants of p73 (DeltaNp73) and with mutant p53. Our findings suggest that the functional impairment of p73 could be involved in the development of thyroid malignancies, defining p73 as a potential therapeutic target for thyroid cancer.

Published
2003

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