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151. Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer

Author

Butt, Julia, Jenab, Mazda, Pawlita, Michael, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mancini, Francesca Romana, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Palli, Domenico, Pala, Valeria Maria, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Gils, Carla H., Vermeulen, Roel C. H., Weiderpass, Elisabete, Quiros, Jose Ramon, Duell, Eric Jeffrey, Sanchez, Maria-Jose, Dorronsoro, Miren, Maria Huerta, Jose, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Perez-Cornago, Aurora, Gunter, Marc J., Murphy, Neil, Freisling, Heinz, Aune, Dagfinn, Waterboer, Tim, Hughes, David J., Butt, Julia, Jenab, Mazda, Pawlita, Michael, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mancini, Francesca Romana, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Palli, Domenico, Pala, Valeria Maria, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Gils, Carla H., Vermeulen, Roel C. H., Weiderpass, Elisabete, Quiros, Jose Ramon, Duell, Eric Jeffrey, Sanchez, Maria-Jose, Dorronsoro, Miren, Maria Huerta, Jose, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Perez-Cornago, Aurora, Gunter, Marc J., Murphy, Neil, Freisling, Heinz, Aune, Dagfinn, Waterboer, Tim, and Hughes, David J.

Abstract

Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Results: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62–1.06). Conclusions: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk. Impact: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.

Published
2019
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152. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status

Author

Fedirko, Veronika, Jenab, Mazda, Meplan, Catherine, Jones, Jeb S., Zhu, Wanzhe, Schomburg, Lutz, Siddiq, Afshan, Hybsier, Sandra, Overvad, Kim, Tjonneland, Anne, Omichessan, Hanane, Perduca, Vittorio, Boutron-Ruault, Marie-Christine, Kuehn, Tilman, Katzke, Verena, Aleksandrova, Krasimira, Trichopoulou, Antonia, Karakatsani, Anna, Kotanidou, Anastasia, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Agnoli, Claudia, Naccarati, Alessio, Bueno-de-Mesquita, Bas, Vermeulen, Roel C. H., Weiderpass, Elisabete, Skeie, Guri, Nost, Therese Haugdahl, Lujan-Barroso, Leila, Ramon Quiros, J., Maria Huerta, Jose, Rodriguez-Barranco, Miguel, Barricarte, Aurelio, Gylling, Björn, Harlid, Sophia, Bradbury, Kathryn E., Wareham, Nick, Khaw, Kay-Tee, Gunter, Marc, Murphy, Neil, Freisling, Heinz, Tsilidis, Kostas, Aune, Dagfinn, Riboli, Elio, Hesketh, John E., Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Meplan, Catherine, Jones, Jeb S., Zhu, Wanzhe, Schomburg, Lutz, Siddiq, Afshan, Hybsier, Sandra, Overvad, Kim, Tjonneland, Anne, Omichessan, Hanane, Perduca, Vittorio, Boutron-Ruault, Marie-Christine, Kuehn, Tilman, Katzke, Verena, Aleksandrova, Krasimira, Trichopoulou, Antonia, Karakatsani, Anna, Kotanidou, Anastasia, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Agnoli, Claudia, Naccarati, Alessio, Bueno-de-Mesquita, Bas, Vermeulen, Roel C. H., Weiderpass, Elisabete, Skeie, Guri, Nost, Therese Haugdahl, Lujan-Barroso, Leila, Ramon Quiros, J., Maria Huerta, Jose, Rodriguez-Barranco, Miguel, Barricarte, Aurelio, Gylling, Björn, Harlid, Sophia, Bradbury, Kathryn E., Wareham, Nick, Khaw, Kay-Tee, Gunter, Marc, Murphy, Neil, Freisling, Heinz, Tsilidis, Kostas, Aune, Dagfinn, Riboli, Elio, Hesketh, John E., and Hughes, David J.

Abstract

Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengateassays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.

Published
2019
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153. Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe : An Update on the EPIC Cohorts Study

Author

Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, Duell, Eric J, Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, and Duell, Eric J

Published
2019

154. Plasma sCD36 as non-circadian marker of chronic circadian disturbance in shift workers

Author

dIRAS RA-2, One Health Chemisch, van de Langenberg, Daniella, Vlaanderen, Jelle J, Dolle, Martijn E T, Handberg, Aase, Vermeulen, Roel C H, van Kerkhof, Linda W M, dIRAS RA-2, One Health Chemisch, van de Langenberg, Daniella, Vlaanderen, Jelle J, Dolle, Martijn E T, Handberg, Aase, Vermeulen, Roel C H, and van Kerkhof, Linda W M

Published
2019

155. Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Author

Din, Lennox, Sheikh, Mohammad, Kosaraju, Nikitha, Smedby, Karin Ekstrom, Bernatsky, Sasha, Berndt, Sonja, I, Skibola, Christine F., Nieters, Alexandra, Wang, Sophia, McKay, James D., Cocco, Pierluigi, Maynadie, Marc, Foretova, Lenka, Staines, Anthony, Mack, Thomas M., de Sanjose, Silvia, Vyse, Timothy J., Padyukov, Leonid, Monnereau, Alain, Arslan, Alan A., Moore, Amy, Brooks-Wilson, Angela R., Novak, Anne J., Glimelius, Bengt, Birmann, Brenda M., Link, Brian K., Stewart, Carolyn, Vajdic, Claire M., Haioun, Corinne, Magnani, Corrado, Conti, David, V, Cox, David G., Casabonne, Delphine, Albanes, Demetrius, Kane, Eleanor, Roman, Eve, Muzi, Giacomo, Salles, Gilles, Giles, Graham G., Adami, Hans-Olov, Ghesquieres, Herve, De Vivo, Immaculata, Clavel, Jacqueline, Cerhan, James R., Spinelli, John J., Hofmann, Jonathan, Vijai, Joseph, Curtin, Karen, Costenbader, Karen H., Onel, Kenan, Offit, Kenneth, Teras, Lauren R., Morton, Lindsay, Conde, Lucia, Miligi, Lucia, Melbye, Mads, Ennas, Maria Grazia, Liebow, Mark, Purdue, Mark P., Glenn, Martha, Southey, Melissa C., Din, Morris, Rothman, Nathaniel, Camp, Nicola J., Doo, Nicole Wong, Becker, Nikolaus, Pradhan, Nisha, Bracci, Paige M., Boffetta, Paolo, Vineis, Paolo, Brennan, Paul, Kraft, Peter, Lan, Qing, Severson, Richard K., Vermeulen, Roel C. H., Milne, Roger L., Kaaks, Rudolph, Travis, Ruth C., Weinstein, Stephanie J., Chanock, Stephen J., Ansell, Stephen M., Slager, Susan L., Zheng, Tongzhang, Zhang, Yawei, Benavente, Yolanda, Taub, Zachary, Madireddy, Lohith, Gourraud, Pierre-Antoine, Oksenberg, Jorge R., Cozen, Wendy, Hjalgrim, Henrik, Khankhanian, Pouya, Din, Lennox, Sheikh, Mohammad, Kosaraju, Nikitha, Smedby, Karin Ekstrom, Bernatsky, Sasha, Berndt, Sonja, I, Skibola, Christine F., Nieters, Alexandra, Wang, Sophia, McKay, James D., Cocco, Pierluigi, Maynadie, Marc, Foretova, Lenka, Staines, Anthony, Mack, Thomas M., de Sanjose, Silvia, Vyse, Timothy J., Padyukov, Leonid, Monnereau, Alain, Arslan, Alan A., Moore, Amy, Brooks-Wilson, Angela R., Novak, Anne J., Glimelius, Bengt, Birmann, Brenda M., Link, Brian K., Stewart, Carolyn, Vajdic, Claire M., Haioun, Corinne, Magnani, Corrado, Conti, David, V, Cox, David G., Casabonne, Delphine, Albanes, Demetrius, Kane, Eleanor, Roman, Eve, Muzi, Giacomo, Salles, Gilles, Giles, Graham G., Adami, Hans-Olov, Ghesquieres, Herve, De Vivo, Immaculata, Clavel, Jacqueline, Cerhan, James R., Spinelli, John J., Hofmann, Jonathan, Vijai, Joseph, Curtin, Karen, Costenbader, Karen H., Onel, Kenan, Offit, Kenneth, Teras, Lauren R., Morton, Lindsay, Conde, Lucia, Miligi, Lucia, Melbye, Mads, Ennas, Maria Grazia, Liebow, Mark, Purdue, Mark P., Glenn, Martha, Southey, Melissa C., Din, Morris, Rothman, Nathaniel, Camp, Nicola J., Doo, Nicole Wong, Becker, Nikolaus, Pradhan, Nisha, Bracci, Paige M., Boffetta, Paolo, Vineis, Paolo, Brennan, Paul, Kraft, Peter, Lan, Qing, Severson, Richard K., Vermeulen, Roel C. H., Milne, Roger L., Kaaks, Rudolph, Travis, Ruth C., Weinstein, Stephanie J., Chanock, Stephen J., Ansell, Stephen M., Slager, Susan L., Zheng, Tongzhang, Zhang, Yawei, Benavente, Yolanda, Taub, Zachary, Madireddy, Lohith, Gourraud, Pierre-Antoine, Oksenberg, Jorge R., Cozen, Wendy, Hjalgrim, Henrik, and Khankhanian, Pouya

Abstract

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p =.0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Published
2019
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156. Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

Author

Projectafdeling ALS, Public Health Practice, Neurogenetica, Brain, ZL Neuromusculaire Ziekten Medisch, Regenerative Medicine and Stem Cells, D'Ovidio, Fabrizio, Rooney, James P K, Visser, Anne E, Manera, Umberto, Beghi, Ettore, Logroscino, Giancarlo, Vermeulen, Roel C H, Veldink, Jan Herman, van den Berg, Leonard H, Hardiman, Orla, Chiò, Adriano, Euro-MOTOR Consortium, Projectafdeling ALS, Public Health Practice, Neurogenetica, Brain, ZL Neuromusculaire Ziekten Medisch, Regenerative Medicine and Stem Cells, D'Ovidio, Fabrizio, Rooney, James P K, Visser, Anne E, Manera, Umberto, Beghi, Ettore, Logroscino, Giancarlo, Vermeulen, Roel C H, Veldink, Jan Herman, van den Berg, Leonard H, Hardiman, Orla, Chiò, Adriano, and Euro-MOTOR Consortium

Published
2019

157. Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Planetary Health & Exposoom, Public Health Practice, MS MDL 1, Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, Duell, Eric J, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Planetary Health & Exposoom, Public Health Practice, MS MDL 1, Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, and Duell, Eric J

Published
2019

158. Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer

Author

MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Public Health Practice, Butt, Julia, Jenab, Mazda, Pawlita, Michael, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mancini, Francesca Romana, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Palli, Domenico, Pala, Valeria Maria, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Gils, Carla H, Vermeulen, Roel C H, Weiderpass, Elisabete, Quirós, José Ramón, Duell, Eric Jeffrey, Sánchez, Maria-Jose, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Van Guelpen, Bethany, Harlid, Sophia, Perez-Cornago, Aurora, Gunter, Marc J, Murphy, Neil, Freisling, Heinz, Aune, Dagfinn, Waterboer, Tim, Hughes, David J, MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Public Health Practice, Butt, Julia, Jenab, Mazda, Pawlita, Michael, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mancini, Francesca Romana, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Palli, Domenico, Pala, Valeria Maria, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Gils, Carla H, Vermeulen, Roel C H, Weiderpass, Elisabete, Quirós, José Ramón, Duell, Eric Jeffrey, Sánchez, Maria-Jose, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Van Guelpen, Bethany, Harlid, Sophia, Perez-Cornago, Aurora, Gunter, Marc J, Murphy, Neil, Freisling, Heinz, Aune, Dagfinn, Waterboer, Tim, and Hughes, David J

Published
2019

159. Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

Author

D'Ovidio, F, Rooney, J, Visser, A, Manera, U, Beghi, E, Logroscino, G, Vermeulen, R, Veldink, J, Van Den Berg, L, Hardiman, O, Chiò, A, D'Ovidio, Fabrizio, Rooney, James P K, Visser, Anne E, Manera, Umberto, Beghi, Ettore, Logroscino, Giancarlo, Vermeulen, Roel C H, Veldink, Jan Herman, Van Den Berg, Leonard H, Hardiman, Orla, Chiò, Adriano, D'Ovidio, F, Rooney, J, Visser, A, Manera, U, Beghi, E, Logroscino, G, Vermeulen, R, Veldink, J, Van Den Berg, L, Hardiman, O, Chiò, A, D'Ovidio, Fabrizio, Rooney, James P K, Visser, Anne E, Manera, Umberto, Beghi, Ettore, Logroscino, Giancarlo, Vermeulen, Roel C H, Veldink, Jan Herman, Van Den Berg, Leonard H, Hardiman, Orla, and Chiò, Adriano

Abstract

Objectives Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case-control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS. Methods Euro-MOTOR is a case-control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design. Logistic regression models adjusted for sex, age, cohort, education, leisure time physical activity, smoking, heart problems, hypertension, stroke, cholesterol and diabetes were performed. Results 1557 patients with ALS and 2922 controls were enrolled in the study. Exposure to alcohol drinking was not significantly associated with ALS risk. A stratified analysis of exposure to alcohol by cohort revealed significant ORs in The Netherlands and in Apulia, with opposite directions (respectively 0.68 and 2.38). With regard to red wine consumption, only in Apulia the double-fold increased risk (OR 2.53) remained significant. A decreased risk was found for current alcohol drinkers (OR 0.83), while a significantly increased risk was detected among former drinkers (OR 1.63). Analysis of cumulative exposure to alcohol revealed no significant associations with ALS risk. Conclusion With few exceptions, no significant association was found between alcohol consumption and ALS. The study of the association between alcohol and ALS requires a thorough exploration, especially considering the role of different type of alcoholic beverages.

Published
2019

160. Long-Term Exposure to Ultrafine Particles and Particulate Matter Constituents and the Risk of Amyotrophic Lateral Sclerosis.

Author

Zhebin Yu, Peters, Susan, van Boxmeer, Loes, Downward, George S., Hoek, Gerard, Kioumourtzoglou, Marianthi-Anna, Weisskopf, Marc G., Hansen, Johnni, van den Berg, Leonard H., and Vermeulen, Roel C. H.

Subjects
PARTICULATE matter, AERODYNAMICS, CONFIDENCE intervals, OXIDATIVE stress, RISK assessment, AMYOTROPHIC lateral sclerosis, DESCRIPTIVE statistics, ODDS ratio, ENVIRONMENTAL exposure, DISEASE risk factors
Abstract

In the article, the authors present their study which examined the effects of long-term exposure to ultrafine particles and particulate matter (PM) on the risk of amyotrophic lateral sclerosis (ALS). Data like body mass index, smoking and alcohol consumption were obtained from the Prospective ALS in the Netherlands (PAN) study from January 2006 to December 2018. Results include the increased odd ratios (OR) for ALS in relation to most air pollutants.

Published
2021
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161. Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

Author

van Vulpen, Jonna K, Schmidt, Martina E, Velthuis, Miranda J, Wiskemann, Joachim, Schneeweiss, Andreas, Vermeulen, Roel C H, Habermann, Nina, Ulrich, Cornelia M, Peeters, Petra H M, van der Wall, Elsken, May, Anne M, Steindorf, Karen, dIRAS RA-2, One Health Chemisch, dIRAS RA-2, One Health Chemisch, and 02 Surgical specialisms

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Physical exercise, Inflammation, Breast Neoplasms, Infammation, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Biomarkers, Tumor, Mechanisms, Aerobic exercise, Humans, Chemotherapy, Young adult, Interleukin 6, Exercise, Mastectomy, Fatigue, Aged, Randomized Controlled Trials as Topic, biology, business.industry, Interleukin-6, Resistance Training, Middle Aged, medicine.disease, Interleukin 1 Receptor Antagonist Protein, Treatment Outcome, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, biology.protein, Quality of Life, Female, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

© 2017 Springer Science+Business Media, LLC, part of Springer Nature Purpose: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy. Methods: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue. Exercise comprised a 12-week resistance training (BEATE study) or an 18-week combined resistance and aerobic training (PACT study). Serum IL-6, IL-1ra, and the IL-6/IL-1ra ratio were quantified at baseline, mid-intervention, post-intervention, and 6–9 months post-baseline. Results: Mixed effect models showed significant increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy and decreases afterwards. Differences between exercise and control group were not significant at any time point. Changes in total cancer-related fatigue were significantly correlated with changes in IL-6/IL-1ra ratio (partial correlation r = 0.23) and IL-6 (r = 0.21), and changes in physical cancer-related fatigue with changes in IL-6/IL-1ra ratio (r = 0.21). Conclusions: Changes in fatigue were slightly correlated with changes in inflammatory markers, and there was a strong inflammatory response to adjuvant chemotherapy. The supervised exercise training did not counteract this increase in inflammation, suggesting that beneficial effects of exercise on fatigue during adjuvant chemotherapy for breast cancer are not essentially mediated by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.

Published
2018

162. Cohort profile: LIFEWORK, a prospective cohort study on occupational and environmental risk factors and health in the Netherlands

Author

Reedijk, Marije, Lenters, Virissa, Slottje, Pauline, Pijpe, Anouk, Peeters, Petra H., Korevaar, Joke C., Bueno-de-Mesquita, H. Bas, Verschuren, W M Monique, Verheij, Robert A., Pieterson, Inka, van Leeuwen, Flora E, Rookus, Matti a, Kromhout, Hans, Vermeulen, Roel C H, One Health Chemisch, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), One Health Chemisch, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), General practice, Plastic, Reconstructive and Hand Surgery, Epidemiology and Data Science, and APH - Quality of Care

Subjects
Male, 010501 environmental sciences, 01 natural sciences, Shift work, 0302 clinical medicine, Risk Factors, Epidemiology, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Non-U.S. Gov't, Netherlands, Aged, 80 and over, General Medicine, Middle Aged, 3. Good health, Cohort, Regression Analysis, Female, epidemiology, Environmental Health, Environmental Monitoring, Cohort study, Adult, electromagnetic fields, medicine.medical_specialty, Nitrogen Dioxide, population-based studies, Research Support, Young Adult, 03 medical and health sciences, Air Pollution, Occupational Exposure, Environmental health, Humans, occupational and environmental exposures, repeatability, Baseline (configuration management), Aged, 0105 earth and related environmental sciences, Occupational and Environmental Medicine, Cohort Profile, Data collection, business.industry, Mobile phone, Particulate Matter, Self Report, business, Cell Phone
Abstract

PurposeLIFEWORK is a large federated prospective cohort established in the Netherlands to quantify the health effects of occupational and environmental exposures. This cohort is also the Dutch contribution to the international Cohort Study of Mobile Phone Use and Health (COSMOS). In this paper, we describe the study design, ongoing data collection, baseline characteristics of participants and the repeatability of key questionnaire items.Participants88 466 participants were enrolled in three cohort studies in 2011–2012. Exposure information was collected by a harmonised core questionnaire, or modelled based on occupational and residential histories; domains include air pollution (eg, nitrogen dioxide (NO2), particulate matter with diameter ≤2.5 µm (PM2.5)), noise, electromagnetic fields (EMF), mobile phone use, shift work and occupational chemical exposures. Chronic and subacute health outcomes are assessed by self-report and through linkage with health registries.Findings to dateParticipants had a median age of 51 years at baseline (range 19–87), and the majority are female (90%), with nurses being over-represented. Median exposure levels of NO2, PM2.5, EMF from base stations and noise at the participants’ home addresses at baseline were 22.9 µg/m3, 16.6 µg/m3, 0.003 mWm2and 53.1 dB, respectively. Twenty-two per cent of participants reported to have started using a mobile phone more than 10 years prior to baseline. Repeatability for self-reported exposures was moderate to high (weighted kappa range: 0.69–1) for a subset of participants (n=237) who completed the questionnaire twice.Future plansWe are actively and passively observing participants; we plan to administer a follow-up questionnaire every 4–5 years—the first follow-up will be completed in 2018—and linkage to cause-of-death and cancer registries occurs on a (bi)annual basis. This prospective cohort offers a unique, large and rich resource for research on contemporary occupational and environmental health risks and will contribute to the large international COSMOS study on mobile phone use and health.

Published
2018
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163. Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study

Author

Veldhoven, Karin van, Keski-Rahkonen, Pekka, Barupal, Dinesh Kumar, Villanueva, Cristina M., Font Ribera, Laia, Scalbert, Augustin, Bodinier, Barbara, Grimalt, Joan O., Zwiener, Christian, Vlaanderen, Jelle, Portengen, Lützen, Vermeulen, Roel C. H., Vineis, Paolo, Chadeau-Hyam, Marc, Kogevinas, Manolis, One Health Chemisch, dIRAS RA-2, Commission of the European Communities, Cancer Research UK, and European Commission

Subjects
Adult, Male, Adolescent, Halogenation, Clor, Article, Young Adult, Swimming Pools, Disinfection by-products, MD Multidisciplinary, Humans, Drinking water, Salut, Piscines, DBPs, lcsh:Environmental sciences, Swimming, lcsh:GE1-350, Aigua potable, Swimming pools, LC-MS, Disinfection, Exposome, Blood, Health, Metabolome, Female, Chlorine, Water Pollutants, Chemical, Environmental Sciences, Environmental Monitoring
Abstract

Background Exposure to disinfection by-products (DBPs) in drinking water and chlorinated swimming pools are associated with adverse health outcomes, but biological mechanisms remain poorly understood. Objectives Evaluate short-term changes in metabolic profiles in response to DBP exposure while swimming in a chlorinated pool. Materials and methods The PISCINA-II study (EXPOsOMICS project) includes 60 volunteers swimming 40 min in an indoor pool. Levels of most common DBPs were measured in water and in exhaled breath before and after swimming. Blood samples, collected before and 2 h after swimming, were used for metabolic profiling by liquid-chromatography coupled to high-resolution mass-spectrometry. Metabolome-wide association between DBP exposures and each metabolic feature was evaluated using multivariate normal (MVN) models. Sensitivity analyses and compound annotation were conducted. Results Exposure levels of all DBPs in exhaled breath were higher after the experiment. A total of 6,471 metabolic features were detected and 293 features were associated with at least one DBP in exhaled breath following Bonferroni correction. A total of 333 metabolic features were associated to at least one DBP measured in water or urine. Uptake of DBPs and physical activity were strongly correlated and mutual adjustment reduced the number of statistically significant associations. From the 293 features, 20 could be identified corresponding to 13 metabolites including compounds in the tryptophan metabolism pathway. Conclusion Our study identified numerous molecular changes following a swim in a chlorinated pool. While we could not explicitly evaluate which experiment-related factors induced these associations, molecular characterization highlighted metabolic features associated with exposure changes during swimming. © 2017 The Authors, This work was supported by the grant FP7 of the European Commission ‘Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe’ (EXPOsOMICS grant 308610 to PV). The Centre for Environment and Health is supported by the Medical Research Council and Public Health England (MR/L01341X/1). Marc Chadeau-Hyam acknowledges support from Cancer Research UK, Population Research Committee Project grant (‘Mechanomics’ project #22184 to MC-H).

Published
2018

166. Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways

Author

Kleinstern, Geffen, primary, Yan, Huihuang, additional, Hildebrandt, Michelle A T, additional, Vijai, Joseph, additional, Berndt, Sonja I, additional, Ghesquières, Hervé, additional, McKay, James, additional, Wang, Sophia S, additional, Nieters, Alexandra, additional, Ye, Yuanqing, additional, Monnereau, Alain, additional, Brooks-Wilson, Angela R, additional, Lan, Qing, additional, Melbye, Mads, additional, Jackson, Rebecca D, additional, Teras, Lauren R, additional, Purdue, Mark P, additional, Vajdic, Claire M, additional, Vermeulen, Roel C H, additional, Giles, Graham G, additional, Cocco, Pier Luigi, additional, Birmann, Brenda M, additional, Kraft, Peter, additional, Albanes, Demetrius, additional, Zeleniuch-Jacquotte, Anne, additional, Crouch, Simon, additional, Zhang, Yawei, additional, Sarangi, Vivekananda, additional, Asmann, Yan, additional, Offit, Kenneth, additional, Salles, Gilles, additional, Wu, Xifeng, additional, Smedby, Karin E, additional, Skibola, Christine F, additional, Slager, Susan L, additional, Rothman, Nathaniel, additional, Chanock, Stephen J, additional, and Cerhan, James R, additional

Published
2019
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167. Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Harms, Laura M., primary, Scalbert, Augustin, additional, Zamora-Ros, Raul, additional, Rinaldi, Sabina, additional, Jenab, Mazda, additional, Murphy, Neil, additional, Achaintre, David, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Romana Mancini, Francesca, additional, Mahamat-Saleh, Yahya, additional, Boutron-Ruault, Marie-Christine, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Trichopoulou, Antonia, additional, Martimianaki, Georgia, additional, Karakatsani, Anna, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel C. H., additional, Weiderpass, Elisabete, additional, Nøst, Therese Haugdahl, additional, Lasheras, Cristina, additional, Rodríguez-Barranco, Miguel, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Dorronsoro, Miren, additional, Hultdin, Johan, additional, Schmidt, Julie A., additional, Gunter, Marc, additional, Riboli, Elio, additional, and Aleksandrova, Krasimira, additional

Published
2019
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168. Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes

Author

Din, Lennox, primary, Sheikh, Mohammad, additional, Kosaraju, Nikitha, additional, Smedby, Karin Ekstrom, additional, Bernatsky, Sasha, additional, Berndt, Sonja I., additional, Skibola, Christine F., additional, Nieters, Alexandra, additional, Wang, Sophia, additional, McKay, James D., additional, Cocco, Pierluigi, additional, Maynadié, Marc, additional, Foretová, Lenka, additional, Staines, Anthony, additional, Mack, Thomas M., additional, de Sanjosé, Silvia, additional, Vyse, Timothy J., additional, Padyukov, Leonid, additional, Monnereau, Alain, additional, Arslan, Alan A., additional, Moore, Amy, additional, Brooks‐Wilson, Angela R., additional, Novak, Anne J., additional, Glimelius, Bengt, additional, Birmann, Brenda M., additional, Link, Brian K., additional, Stewart, Carolyn, additional, Vajdic, Claire M., additional, Haioun, Corinne, additional, Magnani, Corrado, additional, Conti, David V., additional, Cox, David G., additional, Casabonne, Delphine, additional, Albanes, Demetrius, additional, Kane, Eleanor, additional, Roman, Eve, additional, Muzi, Giacomo, additional, Salles, Gilles, additional, Giles, Graham G., additional, Adami, Hans‐Olov, additional, Ghesquières, Hervé, additional, De Vivo, Immaculata, additional, Clavel, Jacqueline, additional, Cerhan, James R., additional, Spinelli, John J., additional, Hofmann, Jonathan, additional, Vijai, Joseph, additional, Curtin, Karen, additional, Costenbader, Karen H., additional, Onel, Kenan, additional, Offit, Kenneth, additional, Teras, Lauren R., additional, Morton, Lindsay, additional, Conde, Lucia, additional, Miligi, Lucia, additional, Melbye, Mads, additional, Ennas, Maria Grazia, additional, Liebow, Mark, additional, Purdue, Mark P., additional, Glenn, Martha, additional, Southey, Melissa C., additional, Din, Morris, additional, Rothman, Nathaniel, additional, Camp, Nicola J., additional, Wong Doo, Nicole, additional, Becker, Nikolaus, additional, Pradhan, Nisha, additional, Bracci, Paige M., additional, Boffetta, Paolo, additional, Vineis, Paolo, additional, Brennan, Paul, additional, Kraft, Peter, additional, Lan, Qing, additional, Severson, Richard K., additional, Vermeulen, Roel C. H., additional, Milne, Roger L., additional, Kaaks, Rudolph, additional, Travis, Ruth C., additional, Weinstein, Stephanie J., additional, Chanock, Stephen J., additional, Ansell, Stephen M., additional, Slager, Susan L., additional, Zheng, Tongzhang, additional, Zhang, Yawei, additional, Benavente, Yolanda, additional, Taub, Zachary, additional, Madireddy, Lohith, additional, Gourraud, Pierre‐Antoine, additional, Oksenberg, Jorge R., additional, Cozen, Wendy, additional, Hjalgrim, Henrik, additional, and Khankhanian, Pouya, additional

Published
2019
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170. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium.

Author

Amadou, Amina, Freisling, Heinz, Jenab, Mazda, Tsilidis, Konstantinos K., Trichopoulou, Antonia, Boffetta, Paolo, Van Guelpen, Bethany, Mokoroa, Olatz, Wilsgaard, Tom, Kee, Frank, Schöttker, Ben, Ordóñez-Mena, José M., Männistö, Satu, Söderberg, Stefan, Vermeulen, Roel C. H., Quirós, J. Ramón, Liao, Linda M., Sinha, Rashmi, Kuulasmaa, Kari, and Brenner, Hermann

Subjects
RESEARCH, META-analysis, RESEARCH methodology, DIABETES, MEDICAL cooperation, EVALUATION research, COLORECTAL cancer, COMPARATIVE studies, AGING, DISEASE prevalence, RESEARCH funding, TUMORS, PROSTATE tumors, BREAST tumors, LONGITUDINAL method
Abstract

Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.Results: A total of 667,916 individuals were included with an overall median (P25-P75) age at recruitment of 62.3 (57-67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86-1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08-1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82-1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77-0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89-1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity.Conclusions: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans. [ABSTRACT FROM AUTHOR]

Published
2021
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171. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Author

McMaster, Mary L, Berndt, Sonja I, Zhang, Jianqing, Slager, Susan L, Li, Shengchao Alfred, Vajdic, Claire M, Smedby, Karin E, Yan, Huihuang, Birmann, Brenda M, Brown, Elizabeth E, Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M, Mayr, Christine, Zhu, Bin, Chung, Charles C, Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D, Hutchinson, Amy, Teras, Lauren R, Adami, Hans-Olov, Bracci, Paige M, McKay, James, Monnereau, Alain, Link, Brian K, Vermeulen, Roel C H, Ansell, Stephen M, Maria, Ann, Diver, W Ryan, Melbye, Mads, Ojesina, Akinyemi I, Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M, Canzian, Federico, Travis, Ruth C, Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L, Novak, Anne J, Lawrence, Charles, Bassig, Bryan A, Lan, Qing, Zheng, Tongzhang, North, Kari E, Tinker, Lesley F, Cozen, Wendy, Severson, Richard K, Hofmann, Jonathan N, Zhang, Yawei, Jackson, Rebecca D, Morton, Lindsay M, Purdue, Mark P, Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R, Chanock, Stephen J, Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R, Skibola, Christine F, Caporaso, Neil E, McMaster, Mary L, Berndt, Sonja I, Zhang, Jianqing, Slager, Susan L, Li, Shengchao Alfred, Vajdic, Claire M, Smedby, Karin E, Yan, Huihuang, Birmann, Brenda M, Brown, Elizabeth E, Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M, Mayr, Christine, Zhu, Bin, Chung, Charles C, Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D, Hutchinson, Amy, Teras, Lauren R, Adami, Hans-Olov, Bracci, Paige M, McKay, James, Monnereau, Alain, Link, Brian K, Vermeulen, Roel C H, Ansell, Stephen M, Maria, Ann, Diver, W Ryan, Melbye, Mads, Ojesina, Akinyemi I, Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M, Canzian, Federico, Travis, Ruth C, Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L, Novak, Anne J, Lawrence, Charles, Bassig, Bryan A, Lan, Qing, Zheng, Tongzhang, North, Kari E, Tinker, Lesley F, Cozen, Wendy, Severson, Richard K, Hofmann, Jonathan N, Zhang, Yawei, Jackson, Rebecca D, Morton, Lindsay M, Purdue, Mark P, Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R, Chanock, Stephen J, Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R, Skibola, Christine F, and Caporaso, Neil E

Abstract

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03, P = 1.36 × 10-54) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45-6.96, P = 8.75 × 10-19). Both risk alleles are observed at a low frequency among controls (~2-3%) and occur in excess in affected cases within families. In silico data suggest that rs116446171 may have functional importance, and in functional studies, we demonstrate increased reporter transcription and proliferation in cells transduced with the 6p25.3 risk allele. Although further studies are needed to fully elucidate underlying biological mechanisms, together these loci explain 4% of the familial risk and provide insights into genetic susceptibility to this malignancy.

Published
2018

172. KIM-1 as a Blood-Based Marker for Early Detection of Kidney Cancer: A Prospective Nested Case-Control Study

Author

Scelo, Ghislaine, Muller, David C, Riboli, Elio, Johansson, Mattias, Cross, Amanda J, Vineis, Paolo, Tsilidis, Konstantinos K, Brennan, Paul, Boeing, Heiner, Peeters, Petra H M, Vermeulen, Roel C H, Overvad, Kim, Bueno-de-Mesquita, H Bas, Severi, Gianluca, Perduca, Vittorio, Kvaskoff, Marina, Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Weiderpass, Elisabete, Sandanger, Torkjel M, Nøst, Therese H, Agudo, Antonio, Quirós, J Ramón, Rodríguez-Barranco, Miguel, Chirlaque, Maria-Dolores, Key, Timothy J, Khanna, Prateek, Bonventre, Joseph V, Sabbisetti, Venkata S, Bhatt, Rupal S, Scelo, Ghislaine, Muller, David C, Riboli, Elio, Johansson, Mattias, Cross, Amanda J, Vineis, Paolo, Tsilidis, Konstantinos K, Brennan, Paul, Boeing, Heiner, Peeters, Petra H M, Vermeulen, Roel C H, Overvad, Kim, Bueno-de-Mesquita, H Bas, Severi, Gianluca, Perduca, Vittorio, Kvaskoff, Marina, Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Weiderpass, Elisabete, Sandanger, Torkjel M, Nøst, Therese H, Agudo, Antonio, Quirós, J Ramón, Rodríguez-Barranco, Miguel, Chirlaque, Maria-Dolores, Key, Timothy J, Khanna, Prateek, Bonventre, Joseph V, Sabbisetti, Venkata S, and Bhatt, Rupal S

Abstract

Purpose: Renal cell carcinoma (RCC) has the potential for cure with surgery when diagnosed at an early stage. Kidney injury molecule-1 (KIM-1) has been shown to be elevated in the plasma of RCC patients. We aimed to test whether plasma KIM-1 could represent a means of detecting RCC prior to clinical diagnosis.Experimental Design: KIM-1 concentrations were measured in prediagnostic plasma from 190 RCC cases and 190 controls nested within a population-based prospective cohort study. Cases had entered the cohort up to 5 years before diagnosis, and controls were matched on cases for date of birth, date at blood donation, sex, and country. We applied conditional logistic regression and flexible parametric survival models to evaluate the association between plasma KIM-1 concentrations and RCC risk and survival.Results: The incidence rate ratio (IRR) of RCC for a doubling in KIM-1 concentration was 1.71 [95% confidence interval (CI), 1.44-2.03, P = 4.1 × 10-23], corresponding to an IRR of 63.3 (95% CI, 16.2-246.9) comparing the 80th to the 20th percentiles of the KIM-1 distribution in this sample. Compared with a risk model including known risk factors of RCC (age, sex, country, body mass index, and tobacco smoking status), a risk model additionally including KIM-1 substantially improved discrimination between cases and controls (area under the receiver-operating characteristic curve of 0.8 compared with 0.7). High plasma KIM-1 concentrations were also associated with poorer survival (P = 0.0053).Conclusions: Plasma KIM-1 concentrations could predict RCC incidence up to 5 years prior to diagnosis and were associated with poorer survival. Clin Cancer Res; 24(22); 5594-601. ©2018 AACR.

Published
2018

173. Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis

Author

Visser, Anne E, Rooney, James P K, D'Ovidio, Fabrizio, Westeneng, Henk-Jan, Vermeulen, Roel C H, Beghi, Ettore, Chiò, Adriano, Logroscino, Giancarlo, Hardiman, Orla, Veldink, Jan H, van den Berg, Leonard H, Euro-MOTOR Consortium, Visser, Anne E, Rooney, James P K, D'Ovidio, Fabrizio, Westeneng, Henk-Jan, Vermeulen, Roel C H, Beghi, Ettore, Chiò, Adriano, Logroscino, Giancarlo, Hardiman, Orla, Veldink, Jan H, van den Berg, Leonard H, and Euro-MOTOR Consortium

Abstract

OBJECTIVE: To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case-control studies in three European countries using a validated and harmonised questionnaire.METHODS: Patients with incident ALS and controls were recruited from five population-based registers in The Netherlands, Ireland and Italy. Demographic and data regarding educational level, smoking, alcohol habits and lifetime PA levels in both leisure and work time were gathered by questionnaire, and quantified using metabolic equivalent of task scores. Logistic regression models adjusting for PA-related factors were used to determine the association between PA and ALS risk, and forest plots were used to visualise heterogeneity between regions.RESULTS: 1557 patients and 2922 controls were included. We found a linear association between ALS and PA in leisure time (OR 1.07, P=0.01) and occupational activities (OR 1.06, P<0.001), and all activities combined (OR 1.06, P<0.001), with some heterogeneity between regions: the most evident association was seen in the Irish and Italian cohorts. After adjustment for other occupational exposures or exclusion of patients with a C9orf72 mutation, the ORs remained similar.CONCLUSION: We provide new class I evidence for a positive association between PA and risk of ALS in a large multicentre study using harmonised methodology to objectively quantify PA levels, with some suggestions for population differences.

Published
2018

174. Modeled and perceived RF-EMF, noise and air pollution and symptoms in a population cohort. Is perception key in predicting symptoms?

Author

Martens, Astrid L, Reedijk, Marije, Smid, Tjabe, Huss, Anke, Timmermans, Danielle R M, Strak, Maciej, Swart, Wim J. R., Lenters, Virissa, Kromhout, Hans, Verheij, Robert A., Slottje, Pauline, Vermeulen, Roel C H, Martens, Astrid L, Reedijk, Marije, Smid, Tjabe, Huss, Anke, Timmermans, Danielle R M, Strak, Maciej, Swart, Wim J. R., Lenters, Virissa, Kromhout, Hans, Verheij, Robert A., Slottje, Pauline, and Vermeulen, Roel C H

Abstract

BACKGROUND: Psychosocial research has shown that perceived exposure can influence symptom reporting, regardless of actual exposure. The impact of this phenomenon on the interpretation of results from epidemiological research on environmental determinants of symptoms is unclear.OBJECTIVE: Our aim was to compare associations between modeled exposures, the perceived level of these exposures and reported symptoms (non-specific symptoms, sleep disturbances, and respiratory symptoms) for three different environmental exposures (radiofrequency electromagnetic fields (RF-EMF), noise, and air pollution). These environmental exposures vary in the degree to which they can be sensorially observed.METHODS: Participant characteristics, perceived exposures, and self-reported health were assessed with a baseline (n = 14,829, 2011/2012) and follow-up (n = 7905, 2015) questionnaire in the Dutch population-based Occupational and Environmental Health Cohort (AMIGO). Environmental exposures were estimated at the home address using spatial models. Cross-sectional and longitudinal regression models were used to examine the associations between modeled and perceived exposures, and reported symptoms.RESULTS: The extent to which exposure sources could be observed by participants likely influenced correlations between modeled and perceived exposure as correlations were moderate for air pollution (rSp = 0.34) and noise (rSp = 0.40), but less so for RF-EMF (rSp = 0.11). Perceived exposures were consistently associated with increased symptom scores (respiratory, sleep, non-specific). Modeled exposures, except RF-EMF, were associated with increased symptom scores, but these associations disappeared or strongly diminished when accounted for perceived exposure in the analyses.DISCUSSION: Perceived exposure has an important role in symptom reporting. When environmental determinants of symptoms are studied without acknowledging the potential role of both modeled and per

Published
2018

175. Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

Author

dIRAS RA-2, One Health Chemisch, van Vulpen, Jonna K, Schmidt, Martina E, Velthuis, Miranda J, Wiskemann, Joachim, Schneeweiss, Andreas, Vermeulen, Roel C H, Habermann, Nina, Ulrich, Cornelia M, Peeters, Petra H M, van der Wall, Elsken, May, Anne M, Steindorf, Karen, dIRAS RA-2, One Health Chemisch, van Vulpen, Jonna K, Schmidt, Martina E, Velthuis, Miranda J, Wiskemann, Joachim, Schneeweiss, Andreas, Vermeulen, Roel C H, Habermann, Nina, Ulrich, Cornelia M, Peeters, Petra H M, van der Wall, Elsken, May, Anne M, and Steindorf, Karen

Published
2018

176. Longitudinal associations between risk appraisal of base stations for mobile phones, radio or television and non-specific symptoms

Author

One Health Chemisch, dIRAS RA-2, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Martens, Astrid L, Slottje, Pauline, Smid, Tjabe, Kromhout, Hans, Vermeulen, Roel C H, Timmermans, Danielle R M, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Martens, Astrid L, Slottje, Pauline, Smid, Tjabe, Kromhout, Hans, Vermeulen, Roel C H, and Timmermans, Danielle R M

Published
2018

177. Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis

Author

One Health Chemisch, dIRAS RA-2, Visser, Anne E, Rooney, James P K, D'Ovidio, Fabrizio, Westeneng, Henk-Jan, Vermeulen, Roel C H, Beghi, Ettore, Chiò, Adriano, Logroscino, Giancarlo, Hardiman, Orla, Veldink, Jan H, van den Berg, Leonard H, Euro-MOTOR Consortium, One Health Chemisch, dIRAS RA-2, Visser, Anne E, Rooney, James P K, D'Ovidio, Fabrizio, Westeneng, Henk-Jan, Vermeulen, Roel C H, Beghi, Ettore, Chiò, Adriano, Logroscino, Giancarlo, Hardiman, Orla, Veldink, Jan H, van den Berg, Leonard H, and Euro-MOTOR Consortium

Published
2018

178. KIM-1 as a Blood-Based Marker for Early Detection of Kidney Cancer: A Prospective Nested Case-Control Study

Author

One Health Chemisch, dIRAS RA-2, Scelo, Ghislaine, Muller, David C, Riboli, Elio, Johansson, Mattias, Cross, Amanda J, Vineis, Paolo, Tsilidis, Konstantinos K, Brennan, Paul, Boeing, Heiner, Peeters, Petra H M, Vermeulen, Roel C H, Overvad, Kim, Bueno-de-Mesquita, H Bas, Severi, Gianluca, Perduca, Vittorio, Kvaskoff, Marina, Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Weiderpass, Elisabete, Sandanger, Torkjel M, Nøst, Therese H, Agudo, Antonio, Quirós, J Ramón, Rodríguez-Barranco, Miguel, Chirlaque, Maria-Dolores, Key, Timothy J, Khanna, Prateek, Bonventre, Joseph V, Sabbisetti, Venkata S, Bhatt, Rupal S, One Health Chemisch, dIRAS RA-2, Scelo, Ghislaine, Muller, David C, Riboli, Elio, Johansson, Mattias, Cross, Amanda J, Vineis, Paolo, Tsilidis, Konstantinos K, Brennan, Paul, Boeing, Heiner, Peeters, Petra H M, Vermeulen, Roel C H, Overvad, Kim, Bueno-de-Mesquita, H Bas, Severi, Gianluca, Perduca, Vittorio, Kvaskoff, Marina, Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Weiderpass, Elisabete, Sandanger, Torkjel M, Nøst, Therese H, Agudo, Antonio, Quirós, J Ramón, Rodríguez-Barranco, Miguel, Chirlaque, Maria-Dolores, Key, Timothy J, Khanna, Prateek, Bonventre, Joseph V, Sabbisetti, Venkata S, and Bhatt, Rupal S

Published
2018

179. Modeled and perceived RF-EMF, noise and air pollution and symptoms in a population cohort. Is perception key in predicting symptoms?

Author

One Health Chemisch, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Martens, Astrid L, Reedijk, Marije, Smid, Tjabe, Huss, Anke, Timmermans, Danielle R M, Strak, Maciej, Swart, Wim J. R., Lenters, Virissa, Kromhout, Hans, Verheij, Robert A., Slottje, Pauline, Vermeulen, Roel C H, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Martens, Astrid L, Reedijk, Marije, Smid, Tjabe, Huss, Anke, Timmermans, Danielle R M, Strak, Maciej, Swart, Wim J. R., Lenters, Virissa, Kromhout, Hans, Verheij, Robert A., Slottje, Pauline, and Vermeulen, Roel C H

Published
2018

180. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Author

One Health Chemisch, dIRAS RA-2, Sub Atmospheric physics and chemistry, McMaster, Mary L, Berndt, Sonja I, Zhang, Jianqing, Slager, Susan L, Li, Shengchao Alfred, Vajdic, Claire M, Smedby, Karin E, Yan, Huihuang, Birmann, Brenda M, Brown, Elizabeth E, Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M, Mayr, Christine, Zhu, Bin, Chung, Charles C, Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D, Hutchinson, Amy, Teras, Lauren R, Adami, Hans-Olov, Bracci, Paige M, McKay, James, Monnereau, Alain, Link, Brian K, Vermeulen, Roel C H, Ansell, Stephen M, Maria, Ann, Diver, W Ryan, Melbye, Mads, Ojesina, Akinyemi I, Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M, Canzian, Federico, Travis, Ruth C, Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L, Novak, Anne J, Lawrence, Charles, Bassig, Bryan A, Lan, Qing, Zheng, Tongzhang, North, Kari E, Tinker, Lesley F, Cozen, Wendy, Severson, Richard K, Hofmann, Jonathan N, Zhang, Yawei, Jackson, Rebecca D, Morton, Lindsay M, Purdue, Mark P, Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R, Chanock, Stephen J, Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R, Skibola, Christine F, Caporaso, Neil E, One Health Chemisch, dIRAS RA-2, Sub Atmospheric physics and chemistry, McMaster, Mary L, Berndt, Sonja I, Zhang, Jianqing, Slager, Susan L, Li, Shengchao Alfred, Vajdic, Claire M, Smedby, Karin E, Yan, Huihuang, Birmann, Brenda M, Brown, Elizabeth E, Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M, Mayr, Christine, Zhu, Bin, Chung, Charles C, Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D, Hutchinson, Amy, Teras, Lauren R, Adami, Hans-Olov, Bracci, Paige M, McKay, James, Monnereau, Alain, Link, Brian K, Vermeulen, Roel C H, Ansell, Stephen M, Maria, Ann, Diver, W Ryan, Melbye, Mads, Ojesina, Akinyemi I, Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M, Canzian, Federico, Travis, Ruth C, Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L, Novak, Anne J, Lawrence, Charles, Bassig, Bryan A, Lan, Qing, Zheng, Tongzhang, North, Kari E, Tinker, Lesley F, Cozen, Wendy, Severson, Richard K, Hofmann, Jonathan N, Zhang, Yawei, Jackson, Rebecca D, Morton, Lindsay M, Purdue, Mark P, Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R, Chanock, Stephen J, Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R, Skibola, Christine F, and Caporaso, Neil E

Published
2018

181. Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy

Author

Epi Kanker Team B, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Divisie Beeld & Oncologie, van Vulpen, Jonna K, Schmidt, Martina E, Velthuis, Miranda J., Wiskemann, Joachim, Schneeweiss, Andreas, Vermeulen, Roel C H, Habermann, Nina, Ulrich, Cornelia M, Peeters, Petra H M, van der Wall, Elsken, May, Anne M, Steindorf, Karen, Epi Kanker Team B, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Divisie Beeld & Oncologie, van Vulpen, Jonna K, Schmidt, Martina E, Velthuis, Miranda J., Wiskemann, Joachim, Schneeweiss, Andreas, Vermeulen, Roel C H, Habermann, Nina, Ulrich, Cornelia M, Peeters, Petra H M, van der Wall, Elsken, May, Anne M, and Steindorf, Karen

Published
2018

182. Cohort profile: LIFEWORK, a prospective cohort study on occupational and environmental risk factors and health in the Netherlands

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Reedijk, Marije, Lenters, Virissa, Slottje, Pauline, Pijpe, Anouk, Peeters, Petra H, Korevaar, Joke C, Bueno-de-Mesquita, Bas, Verschuren, W M Monique, Verheij, Robert A, Pieterson, Inka, van Leeuwen, Flora E, Rookus, Matti A, Kromhout, Hans, Vermeulen, Roel C H, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Reedijk, Marije, Lenters, Virissa, Slottje, Pauline, Pijpe, Anouk, Peeters, Petra H, Korevaar, Joke C, Bueno-de-Mesquita, Bas, Verschuren, W M Monique, Verheij, Robert A, Pieterson, Inka, van Leeuwen, Flora E, Rookus, Matti A, Kromhout, Hans, and Vermeulen, Roel C H

Published
2018

183. Modeled and perceived RF-EMF, noise and air pollution and symptoms in a population cohort. Is perception key in predicting symptoms?

Author

Martens, Astrid L, Reedijk, Marije, Smid, Tjabe, Huss, Anke, Timmermans, Danielle R M, Strak, Maciej, Swart, Wim J. R., Lenters, Virissa, Kromhout, Hans, Verheij, Robert A., Slottje, Pauline, Vermeulen, Roel C H, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Public and occupational health, APH - Societal Participation & Health, APH - Quality of Care, General practice, APH - Personalized Medicine, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), and LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.)

Subjects
medicine.medical_specialty, Environmental Engineering, RF-EMF base stations, Radio Waves, media_common.quotation_subject, Air pollution, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Electromagnetic Fields, Environmental health, Perception, Air Pollution, Epidemiology, Medicine, Environmental Chemistry, Humans, Noise (traffic), 030212 general & internal medicine, Waste Management and Disposal, 0105 earth and related environmental sciences, media_common, Health risk assessment, Symptom reporting, business.industry, Multidisciplinary longitudinal cohort study, food and beverages, Regression analysis, Environmental Exposure, Pollution, Cross-Sectional Studies, Public Opinion, Cohort, Etiology, Air pollutants (traffic), perceived exposure, business, Noise, Psychosocial
Abstract

Background: Psychosocial research has shown that perceived exposure can influence symptom reporting, regardless of actual exposure. The impact of this phenomenon on the interpretation of results from epidemiological research on environmental determinants of symptoms is unclear. Objective: Our aim was to compare associations between modeled exposures, the perceived level of these exposures and reported symptoms (non-specific symptoms, sleep disturbances, and respiratory symptoms) for three different environmental exposures (radiofrequency electromagnetic fields (RF-EMF), noise, and air pollution). These environmental exposures vary in the degree to which they can be sensorially observed. Methods: Participant characteristics, perceived exposures, and self-reported health were assessed with a baseline (n = 14,829, 2011/2012) and follow-up (n = 7905, 2015) questionnaire in the Dutch population-based Occupational and Environmental Health Cohort (AMIGO). Environmental exposures were estimated at the home address using spatial models. Cross-sectional and longitudinal regression models were used to examine the associations between modeled and perceived exposures, and reported symptoms. Results: The extent to which exposure sources could be observed by participants likely influenced correlations between modeled and perceived exposure as correlations were moderate for air pollution (rSp = 0.34) and noise (rSp = 0.40), but less so for RF-EMF (rSp = 0.11). Perceived exposures were consistently associated with increased symptom scores (respiratory, sleep, non-specific). Modeled exposures, except RF-EMF, were associated with increased symptom scores, but these associations disappeared or strongly diminished when accounted for perceived exposure in the analyses. Discussion: Perceived exposure has an important role in symptom reporting. When environmental determinants of symptoms are studied without acknowledging the potential role of both modeled and perceived exposures, there is a risk of bias in health risk assessment. However, the etiological role of exposure perceptions in relation to symptom reporting requires further research.

Published
2017
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184. THE AUTHORS REPLY 'MODELED AND PERCEIVED EXPOSURE TO RADIOFREQUENCY ELECTROMAGNETIC FIELDS FROM MOBILE-PHONE BASE STATIONS AND THE DEVELOPMENT OF SYMPTOMS OVER TIME IN A GENERAL POPULATION COHORT'

Author

Martens, Astrid L, Slottje, Pauline, Timmermans, Danielle R M, Kromhout, Hans, Reedijk, Marije, Smid, Tjabe, Vermeulen, Roel C H, Public and occupational health, General practice, APH - Quality of Care, APH - Societal Participation & Health, and APH - Personalized Medicine

Published
2017
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185. Maternal occupational exposure and oral clefts in offspring

Author

Spinder, Nynke, Bergman, Jorieke E H, Boezen, H. Marike, Vermeulen, Roel C H, Kromhout, Hans, de Walle, Hermien E K, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Reproductive Origins of Adult Health and Disease (ROAHD), Groningen Research Institute for Asthma and COPD (GRIAC), Life Course Epidemiology (LCE), LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), and dIRAS RA-2

Subjects
Male, ANOMALIES, Congenital anomalies, ORGANIC-SOLVENTS, Health, Toxicology and Mutagenesis, Dentistry, Physiology, 0302 clinical medicine, PESTICIDES, Risk Factors, 030212 general & internal medicine, POPULATION, Netherlands, education.field_of_study, Teratology, lcsh:Public aspects of medicine, Congenital malformations, Dust, Occupational exposure, 030210 environmental & occupational health, CONGENITAL-MALFORMATIONS, Cleft Palate, PREGNANCY, Maternal Exposure, Metals, lcsh:Industrial medicine. Industrial hygiene, Biological dust, Environmental Pollutants, Female, NEURAL-TUBE DEFECTS, Gases, Job-exposure matrix, Adult, Adolescent, Offspring, Cleft Lip, Population, complex mixtures, Mineral dust, 03 medical and health sciences, lcsh:RC963-969, Young Adult, Occupational Exposure, medicine, Journal Article, Humans, Pesticides, education, METAANALYSIS, Pregnancy, business.industry, Research, Public Health, Environmental and Occupational Health, Case-control study, Infant, Newborn, Infant, OROFACIAL CLEFTS, lcsh:RA1-1270, Newborn, medicine.disease, respiratory tract diseases, Case-Control Studies, Solvents, RISK-FACTORS, business
Abstract

Background: Previous studies suggest that periconceptional maternal occupational exposure to solvents and pesticides increase the risk of oral clefts in the offspring. Less is known about the effect of occupational exposure to metals, dust, and gases and fumes on development of oral clefts.Methods: This case-malformed control study used data from a population-based birth defects registry (Eurocat) of children and foetuses born in the Northern Netherlands between 1997 and 2013. Cases were defined as non-syndromic oral clefts. The first control group had chromosomal/monogenic defects, and the second control group was defined as non-chromosomal/non-monogenic malformed controls. Maternal occupational exposure was estimated through linkage of mothers' occupation with a community-based Job Exposure Matrix (JEM). Multivariate logistic regression was used to estimate the effect of occupational exposures. Odds ratios were adjusted (aORs) for relevant confounders.Results: A total of 387 cases, 1135 chromosomal and 4352 non-chromosomal malformed controls were included in this study. Prevalence of maternal occupational exposures to all agents was 43.9% and 41.0%/37.7% among cases and controls, respectively. Oral clefts had significantly increased ORs of maternal occupational exposure to pesticides (aOR = 1.7, 95% confidence interval [CI] 1.0-3.1) and dust (aOR = 1.3, 95% CI 1.1-1.6) when using non-chromosomal controls. Subgroup analysis for CL(P) stratified by gender showed a significantly increased risk for male infants exposed to 'other solvents' and exposure to mineral dust for female infants.Conclusion: Our study showed that maternal occupational exposure to pesticides and dust are risk factors for oral clefts in the offspring. Larger studies are needed to confirm this finding.

Published
2017

186. Critical issues in ALS case-control studies: the case of the Euro-MOTOR study

Author

D'Ovidio, Fabrizio, Rooney, James P K, Visser, Anne E, Vermeulen, Roel C H, Veldink, Jan H., van den Berg, Leonard H., Hardiman, Orla, Logroscino, Giancarlo, Chiò, Adriano, Beghi, Ettore, Euro-MOTOR Group, dIRAS RA-2, and LS IRAS EEPI ME (Milieu epidemiologie)

Subjects
case-control study, criticisms, epidemiology, genetics, risk
Abstract

Backround: Political and sociocultural differences between countries can affect the outcome of clinical and epidemiological studies in ALS. Cross-national studies represent the ideal process by which risk factors can be assessed using the same methodology in different geographical areas. METHODS: A survey of three European countries (The Netherlands, Ireland and Italy) has been conducted in which incident ALS patients and matched controls were recruited in a population-based study based on age, gender and area of residency, under the Euro-MOTOR systems biology programme of research. FINDINGS: We have identified strengths and limitations during the trajectory of the Euro-MOTOR study, from the research design to data analysis. We have analysed the implications of factors including cross-national differences in healthcare systems, sample size, types of matching, the definition of exposures and statistical analysis. CONCLUSIONS: Addressing critical methodological aspects of the design of the Euro-MOTOR project minimises bias and will facilitate scientific assessment of the independent role of well-defined exposures.

Published
2017

187. High-Resolution Air Pollution Mapping with Google Street View Cars: Exploiting Big Data

Author

Apte, Joshua S, Messier, Kyle P, Gani, Shahzad, Brauer, Michael, Kirchstetter, Thomas W, Lunden, Melissa M, Marshall, Julian D, Portier, Christopher J, Vermeulen, Roel C H, Hamburg, Steven P, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Toxicogenomics, RS: FHML non-thematic output, LS IRAS EEPI ME (Milieu epidemiologie), and dIRAS RA-2

Subjects
Pollution, 010504 meteorology & atmospheric sciences, Meteorology, media_common.quotation_subject, Big data, Air pollution, High resolution, PM2.5, 010501 environmental sciences, MAJOR HIGHWAY, URBAN, medicine.disease_cause, 01 natural sciences, Orders of magnitude (specific energy), Air Pollution, Ultrafine particle, medicine, Humans, Environmental Chemistry, LAND-USE REGRESSION, EXPOSURE, Air quality index, 0105 earth and related environmental sciences, media_common, MOBILE, Air Pollutants, ULTRAFINE PARTICLES, business.industry, General Chemistry, Particulates, GLOBAL BURDEN, PARTICLE NUMBER CONCENTRATIONS, BLACK CARBON, Environmental science, Particulate Matter, Public Health, business, Automobiles, Environmental Monitoring
Abstract

Air pollution affects billions of people worldwide, yet ambient pollution measurements are limited for much of the world. Urban air pollution concentrations vary sharply over short distances (≪1 km) owing to unevenly distributed emission sources, dilution, and physicochemical transformations. Accordingly, even where present, conventional fixed-site pollution monitoring methods lack the spatial resolution needed to characterize heterogeneous human exposures and localized pollution hotspots. Here, we demonstrate a measurement approach to reveal urban air pollution patterns at 4-5 orders of magnitude greater spatial precision than possible with current central-site ambient monitoring. We equipped Google Street View vehicles with a fast-response pollution measurement platform and repeatedly sampled every street in a 30-km2 area of Oakland, CA, developing the largest urban air quality data set of its type. Resulting maps of annual daytime NO, NO2, and black carbon at 30 m-scale reveal stable, persistent pollution patterns with surprisingly sharp small-scale variability attributable to local sources, up to 5-8× within individual city blocks. Since local variation in air quality profoundly impacts public health and environmental equity, our results have important implications for how air pollution is measured and managed. If validated elsewhere, this readily scalable measurement approach could address major air quality data gaps worldwide.

Published
2017

188. Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage

Author

Vlaanderen, Jelle, Leenders, Max, Chadeau-Hyam, Marc, Portengen, Lützen, Kyrtopoulos, Soterios A, Bergdahl, Ingvar A, Johansson, Ann-Sofie, Hebels, Dennie D G A J, de Kok, Theo M C M, Vineis, Paolo, Vermeulen, Roel C H, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Sub IRAS EEPI Algemeen, dIRAS RA-2, CBITE, RS: MERLN - Cell Biology - Inspired Tissue Engineering (CBITE), Toxicogenomics, RS: GROW - R1 - Prevention, RS: FHML MaCSBio, RS: FPN MaCSBio, RS: FSE MaCSBio, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Sub IRAS EEPI Algemeen, and dIRAS RA-2

Subjects
0301 basic medicine, Oncology, Chronic lymphocytic leukemia, Disease, Bioinformatics, Transcriptome, B-cell lymphoma, Multiple myeloma, Genetics & Heredity, GENE-EXPRESSION DATA, 11 Medical And Health Sciences, Prognosis, CANCER, OPPORTUNITIES, symbols, Public data, DNA microarray, Life Sciences & Biomedicine, Research Article, Biotechnology, medicine.medical_specialty, Biology, 03 medical and health sciences, symbols.namesake, MOLECULAR EPIDEMIOLOGY, Internal medicine, MULTIPLE-MYELOMA, medicine, Biomarkers, Tumor, Genetics, Humans, Transcriptomics, Neoplasm Staging, 08 Information And Computing Sciences, Cancer och onkologi, Science & Technology, Gene Expression Profiling, Cancer, Computational Biology, 06 Biological Sciences, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, 030104 developmental biology, Bonferroni correction, Biotechnology & Applied Microbiology, Cancer and Oncology, Prediagnostic study, T-CELLS, UPDATE, CLL
Abstract

Background We recently identified 700 genes whose expression levels were predictive of chronic lymphocytic leukemia (CLL) in a genome-wide gene expression analysis of prediagnostic blood from future cases and matched controls. We hypothesized that a large fraction of these markers were likely related to early disease manifestations. Here we aim to gain a better understanding of the natural history of the identified markers by comparing results from our prediagnostic analysis, the only prediagnostic analysis to date, to results obtained from a meta-analysis of a series of publically available transcriptomics profiles obtained in incident CLL cases and controls. Results We observed considerable overlap between the results from our prediagnostic study and the clinical CLL signals (p-value for overlap Bonferroni significant markers 0.01; p-value for overlap nominal significant markers

Published
2017

189. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Author

Law, Philip J, Berndt, Sonja I, Speedy, Helen E, Camp, Nicola J, Sava, Georgina P, Skibola, Christine F, Holroyd, Amy, Joseph, Vijai, Sunter, Nicola J, Nieters, Alexandra, Bea, Silvia, Monnereau, Alain, Martin-Garcia, David, Goldin, Lynn R, Clot, Guillem, Teras, Lauren R, Quintela, Inés, Birmann, Brenda M, Jayne, Sandrine, Cozen, Wendy, Majid, Aneela, Smedby, Karin E, Lan, Qing, Dearden, Claire, Brooks-Wilson, Angela R., Hall, Andrew G, Purdue, Mark P, Mainou-Fowler, Tryfonia, Vajdic, Claire M, Jackson, Graham H, Cocco, Pierluigi, Marr, Helen, Zhang, Yawei, Zheng, Tongzhang, Giles, Graham G, Lawrence, Charles, Call, Timothy G, Liebow, Mark, Melbye, Mads, Glimelius, Bengt, Mansouri, Larry, Glenn, Martha, Curtin, Karen, Diver, W Ryan, Link, Brian K, Conde, Lucia, Bracci, Paige M., Holly, Elizabeth A, Jackson, Rebecca D, Tinker, Lesley F, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Albanes, Demetrius, Weinstein, Stephanie, Wang, Zhaoming, Caporaso, Neil E., Morton, Lindsay M, Severson, Richard K, Riboli, Elio, Vineis, Paolo, Vermeulen, Roel C H, Southey, Melissa C, Milne, Roger L., Clavel, Jacqueline, Topka, Sabine, Spinelli, John J, Kraft, Peter, Ennas, Maria Grazia, Summerfield, Geoffrey, Ferri, Giovanni M, Harris, Robert J, Miligi, Lucia, Pettitt, Andrew R, North, Kari E, Allsup, David J, Fraumeni, Joseph F, Bailey, James R, Offit, Kenneth, Pratt, Guy, Hjalgrim, Henrik, Pepper, Christopher, Chanock, Stephen J, Fegan, Chris, Rosenquist, Richard, de Sanjose, Silvia, Carracedo, Angel, Dyer, Martin J S, Catovsky, Daniel, Campo, Elias, Cerhan, James R., Allan, James M, Rothman, Nathanial, Houlston, Richard, Slager, Susan, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Microsoft Research [Redmond], Microsoft Corporation [Redmond, Wash.], Department of Physics, Loyola College, Nungambakkam, Chennai – 600 034, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), University of Aleppo [Aleppo], Sea Mammal Research Unit [University of St Andrews] (SMRU), School of Biology [University of St Andrews], University of St Andrews [Scotland]-University of St Andrews [Scotland]-Natural Environment Research Council (NERC), Department of Chemical Engineering, Imperial College London, De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies (MONARIS), Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), The Cancer Council Victoria, University of Oulu, Uppsala Universitet [Uppsala], Université Paris Nanterre (UPN), University of Iowa [Iowa City], Registre des hémopathies malignes de Côte d'Or, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), B.B. Brodie Department of Neuroscience, Pennsylvania State University (Penn State), Penn State System, University of Newcastle [Australia] (UoN), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Department of Haematology, School of Medicine, Cardiff University, CIBER de Enfermedades Raras (CIBERER), University of Leeds, Haemato-oncology, Institute of cancer research, Mayo Clinic [Rochester], Northern Institute for Cancer Research [Newcastle] (NICR), Newcastle University [Newcastle], Institute of Cancer Research, Belmont, Sutton, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Sea Mammal Research Unit, Scottish Oceans Institute, University of St Andrews [Scotland], Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), University of Cardiff, Équipe Instrumentation embarquée et systèmes de surveillance intelligents (LAAS-S4M), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J), University of Newcastle [Callaghan, Australia] (UoN), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Université Toulouse 1 Capitole (UT1)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
Adult, Male, RM, Cancer och onkologi, B-Lymphocytes, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Science, Chromosome Mapping, Middle Aged, Leukemia, Lymphocytic, Chronic, B-Cell, Polymorphism, Single Nucleotide, Article, Young Adult, Cancer and Oncology, Case-Control Studies, Antibody Formation, Chromosomes, Human, Humans, Female, Genetic Predisposition to Disease, RC, Genome-Wide Association Study
Abstract

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response., Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

Published
2017
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190. A longitudinal study of atrazine and 2,4-D exposure and oxidative stress markers among iowa corn farmers

Author

Lerro, Catherine C, Beane Freeman, Laura E, Portengen, Lützen, Kang, Daehee, Lee, Kyoungho, Blair, Aaron, Lynch, Charles F, Bakke, Berit, De Roos, Anneclaire J., Vermeulen, Roel C H, Sub IRAS EEPI Algemeen, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, and dIRAS RA-I&I RA

Subjects
Adult, Male, Farmers, Herbicides, Deoxyguanosine, Air Pollutants, Occupational, Middle Aged, Dinoprost, Iowa, Oxidative Stress, Malondialdehyde, Occupational Exposure, Multivariate Analysis, Journal Article, Humans, Atrazine, Lipid Peroxidation, Longitudinal Studies, 2,4-Dichlorophenoxyacetic Acid, Biomarkers
Abstract

Reactive oxygen species, potentially formed through environmental exposures, can overwhelm an organism's antioxidant capabilities resulting in oxidative stress. Long-term oxidative stress is linked with chronic diseases. Pesticide exposures have been shown to cause oxidative stress in vivo. We utilized a longitudinal study of corn farmers and non-farming controls in Iowa to examine the impact of exposure to the widely used herbicides atrazine and 2,4-dichlorophenoxyacetic acid (2,4-D) on markers of oxidative stress. 225 urine samples were collected during five agricultural time periods (pre-planting, planting, growing, harvest, off-season) for 30 farmers who applied pesticides occupationally and 10 controls who did not; all were non-smoking men ages 40-60. Atrazine mercapturate (atrazine metabolite), 2,4-D, and oxidative stress markers (malondialdehyde [MDA], 8-hydroxy-2'-deoxyguanosine [8-OHdG], and 8-isoprostaglandin-F2α [8-isoPGF]) were measured in urine. We calculated β estimates and 95% confidence intervals (95%CI) for each pesticide-oxidative stress marker combination using multivariate linear mixed-effect models for repeated measures. Farmers had higher urinary atrazine mercapturate and 2,4-D levels compared with controls. In regression models, after natural log transformation, 2,4-D was associated with elevated levels of 8-OHdG (β = 0.066, 95%CI = 0.008-0.124) and 8-isoPGF (β = 0.088, 95%CI = 0.004-0.172). 2,4-D may be associated with oxidative stress because of modest increases in 8-OHdG, a marker of oxidative DNA damage, and 8-isoPGF, a product of lipoprotein peroxidation, with recent 2,4-D exposure. Future studies should investigate the role of 2,4-D-induced oxidative stress in the pathogenesis of human diseases. Environ. Mol. Mutagen. 58:30-38, 2017. © 2016 Wiley Periodicals, Inc.

Published
2017

192. Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways.

Author

Kleinstern, Geffen, Yan, Huihuang, Hildebrandt, Michelle A T, Vijai, Joseph, Berndt, Sonja I, Ghesquières, Hervé, McKay, James, Wang, Sophia S, Nieters, Alexandra, Ye, Yuanqing, Monnereau, Alain, Brooks-Wilson, Angela R, Lan, Qing, Melbye, Mads, Jackson, Rebecca D, Teras, Lauren R, Purdue, Mark P, Vajdic, Claire M, Vermeulen, Roel C H, and Giles, Graham G

Published
2020
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194. Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?

Author

Wang, Feng, primary, Zhang, Liuzhuo, additional, Wu, Suyang, additional, Li, Wentao, additional, Sun, Miaomiao, additional, Feng, Wenting, additional, Ding, Ding, additional, Yeung-shan Wong, Samuel, additional, Zhu, Peng, additional, Evans, Greg J, additional, Wing, Yun Kwok, additional, Zhang, Jihui, additional, Vlaanderen, Jelle J, additional, Vermeulen, Roel C H, additional, Zhang, Yanfang, additional, Chan, Emily Ying-yang, additional, Li, Zhimin, additional, and Tse, Lap Ah, additional

Published
2018
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195. Mapping Air Pollution with Google Street View Cars: Efficient Approaches with Mobile Monitoring and Land Use Regression

Author

Messier, Kyle P., primary, Chambliss, Sarah E., additional, Gani, Shahzad, additional, Alvarez, Ramon, additional, Brauer, Michael, additional, Choi, Jonathan J., additional, Hamburg, Steven P., additional, Kerckhoffs, Jules, additional, LaFranchi, Brian, additional, Lunden, Melissa M., additional, Marshall, Julian D., additional, Portier, Christopher J., additional, Roy, Ananya, additional, Szpiro, Adam A., additional, Vermeulen, Roel C. H., additional, and Apte, Joshua S., additional

Published
2018
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196. Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

Author

D'Ovidio, Fabrizio, primary, Rooney, James P K, additional, Visser, Anne E, additional, Manera, Umberto, additional, Beghi, Ettore, additional, Logroscino, Giancarlo, additional, Vermeulen, Roel C H, additional, Veldink, Jan Herman, additional, van den Berg, Leonard H, additional, Hardiman, Orla, additional, and Chiò, Adriano, additional

Published
2018
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197. Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

Author

Visser, Anne E, primary, Rooney, James P K, additional, D’Ovidio, Fabrizio, additional, Westeneng, Henk-Jan, additional, Vermeulen, Roel C H, additional, Beghi, Ettore, additional, Chiò, Adriano, additional, Logroscino, Giancarlo, additional, Hardiman, Orla, additional, Veldink, Jan H, additional, and van den Berg, Leonard H, additional

Published
2018
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198. Chronotype in relation to shift work: A cohort study among 37,731 female nurses.

Author

Bruijn, Linske, Berentzen, Nina E., Vermeulen, Roel C. H., Vlaanderen, Jelle J., Kromhout, Hans, Leeuwen, Flora E., and Schaapveld, Michael

Subjects
*SLEEP, *SLEEP quality, *CHRONOTYPE, *SHIFT systems, *POISSON regression, *MORNINGNESS-Eveningness Questionnaire
Abstract

Summary Chronotype may affect tolerance for circadian disruption induced by shift work. This study examines the association between chronotype, self‐reported sleep timing, shift type preference, and sleep problems among nurses, and studies chronotype stability over time. The study included 37,731 Dutch female nurses who completed a baseline (2011) and follow‐up questionnaire (2017), with information on shift work (e.g., job history, shift type preference [collected in 2017 only]), and sleep characteristics (e.g., chronotype, preferred sleep–wake time in a work‐free period [collected in 2017 only], and sleep problems between working days according to Medical Outcomes Study‐Sleep Problem Index II [MOS‐SPI‐II]). The association between chronotype and sleep timing was examined using (age‐adjusted) linear regression. Associations between chronotype and shift type preference and sleep problems (MOS‐SPI‐II >30) were examined using ordered logistic and Poisson regression, respectively. With later chronotype, midsleep time increased (definite evening vs. intermediate types [reference]: β = 55 min, 95% confidence interval [95% CI]: 54–55), the odds ratio (OR) for 1‐point increase in preference for night (2.68; 95% CI: 2.48–2.90) and evening shifts increased (OR 2.20; 95% CI: 2.03–2.38), while the odds for day (OR 0.17; 95% CI: 0.16–0.18) and morning shifts (OR 0.22; 95% CI: 0.21–0.24) decreased. Intermediate chronotype was associated with fewer sleep problems (median MOS‐SPI‐II = 27.2, p < 0.01), compared with definite morning (28.9) and evening types (31.7). This study shows that chronotype is associated with sleep–wake times in a work‐free period, shift type preference, and sleep problems in nurses. Future studies on the association of shift work‐induced circadian disruption and health outcomes should therefore consider chronotype as effect‐modifier. [ABSTRACT FROM AUTHOR]

Published
2024
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199. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Author

Bernatsky, Sasha, Velásquez García, Héctor A, Spinelli, John, Gaffney, Patrick, Smedby, Karin E, Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H, Cox, David G, Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., De Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquières, Hervé, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, McKay, James, Melbye, Mads, Molina, Thierry Jo, Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C H, Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, Clarke, Ann E, Bernatsky, Sasha, Velásquez García, Héctor A, Spinelli, John, Gaffney, Patrick, Smedby, Karin E, Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H, Cox, David G, Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., De Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquières, Hervé, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, McKay, James, Melbye, Mads, Molina, Thierry Jo, Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C H, Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, and Clarke, Ann E

Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

Published
2017

200. Toward Greater Implementation of the Exposome Research Paradigm within Environmental Epidemiology

Author

Stingone, Jeanette A, Buck Louis, Germaine M, Nakayama, Shoji F, Vermeulen, Roel C H, Kwok, Richard K, Cui, Yuxia, Balshaw, David M, Teitelbaum, Susan L, Stingone, Jeanette A, Buck Louis, Germaine M, Nakayama, Shoji F, Vermeulen, Roel C H, Kwok, Richard K, Cui, Yuxia, Balshaw, David M, and Teitelbaum, Susan L

Abstract

Investigating a single environmental exposure in isolation does not reflect the actual human exposure circumstance nor does it capture the multifactorial etiology of health and disease. The exposome, defined as the totality of environmental exposures from conception onward, may advance our understanding of environmental contributors to disease by more fully assessing the multitude of human exposures across the life course. Implementation into studies of human health has been limited, in part owing to theoretical and practical challenges including a lack of infrastructure to support comprehensive exposure assessment, difficulty in differentiating physiologic variation from environmentally induced changes, and the need for study designs and analytic methods that accommodate specific aspects of the exposome, such as high-dimensional exposure data and multiple windows of susceptibility. Recommendations for greater data sharing and coordination, methods development, and acknowledgment and minimization of multiple types of measurement error are offered to encourage researchers to embark on exposome research to promote the environmental health and well-being of all populations.

Published
2017

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