403 results on '"Venugopal B"'
Search Results
152. Macroporous metal oxide foams through self-sustained combustion reactions
- Author
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Venugopal, B. R., primary, Samuel, Ezra P., additional, Shivakumara, C., additional, and Rajamathi, Michael, additional
- Published
- 2008
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153. Delamination of surfactant intercalated smectites in alcohols: Effect of chain length of the solvent
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VENUGOPAL, B, primary, SEN, S, additional, SHIVAKUMARA, C, additional, and RAJAMATHI, M, additional
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- 2006
- Full Text
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154. Layered Double Hydroxide−CdSe Quantum Dot Composites through Colloidal Processing: Effect of Host Matrix−Nanoparticle Interaction on Optical Behavior
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Venugopal, B. R., primary, Ravishankar, N., additional, Perrey, Christopher R., additional, Shivakumara, C., additional, and Rajamathi, Michael, additional
- Published
- 2005
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155. Biosorption of Cr(VI) Using Cellulose Nanocrystals Isolated from the Waterless Pulping of Waste Cotton Cloths with Supercritical CO2: Isothermal, Kinetics, and Thermodynamics Studies
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Siti Hajar Mohamed, Md. Sohrab Hossain, Mohamad Haafiz Mohamad Kassim, Venugopal Balakrishnan, Mohamed A. Habila, Azham Zulkharnain, Muzafar Zulkifli, and Ahmad Naim Ahmad Yahaya
- Subjects
waste cotton cloths ,cellulose nanocrystals ,solid waste management ,supercritical CO2 ,heavy metals adsorption ,sustainability ,Organic chemistry ,QD241-441 - Abstract
In the present study, supercritical carbon dioxide (scCO2) was utilized as a waterless pulping for the isolation of cellulose nanocrystals (CNCs) from waste cotton cloths (WCCs). The isolation of CNCs from the scCO2-treated WCCs’ fiber was carried out using sulphuric acid hydrolysis. The morphological and physicochemical properties analyses showed that the CNCs isolated from the WCCs had a rod-like structure, porous surface, were crystalline, and had a length of 100.03 ± 1.15 nm and a width of 7.92 ± 0.53 nm. Moreover, CNCs isolated from WCCs had a large specific surface area and a negative surface area with uniform nano-size particles. The CNCs isolated from WCCs were utilized as an adsorbent for the hexavalent chromium [Cr(VI)] removal from aqueous solution with varying parameters, such as treatment time, adsorbent doses, pH, and temperature. It was found that the CNCs isolated from the WCCs were a bio-sorbent for the Cr(VI) removal. The maximum Cr(VI) removal was determined to be 96.97% at pH 2, 1.5 g/L of adsorbent doses, the temperature of 60 °C, and the treatment time of 30 min. The adsorption behavior of CNCs for Cr(VI) removal was determined using isothermal, kinetics, and thermodynamics properties analyses. The findings of the present study revealed that CNCs isolated from the WCCs could be utilized as a bio-sorbent for Cr(VI) removal.
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- 2022
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156. Laparoscopic cholecystectomy in acute cholecystitis
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Prakash, K., primary, Jacob, G., additional, Lekha, V., additional, Venugopal, A., additional, Venugopal, B., additional, and Ramesh, H., additional
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- 2001
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157. Plasminogen activator inhibitor-1 in cardiovascular cells: rapid induction after injecting mice with kainate or adrenergic agents
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Venugopal, B, primary
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- 2001
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158. Influence of Fresh Palm Fruit Sterilization in the Production of Carotenoid-Rich Virgin Palm Oil
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Nik Suhaimi Mat Hassan, Md. Sohrab Hossain, Venugopal Balakrishnan, Mark Harris Zuknik, Muliadi Mustaner, Azhar Mat Easa, Adel Al-Gheethi, and Ahmad Naim Ahmad Yahaya
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virgin palm oil ,cold-press extraction ,sterilization ,oil palm fruits ,Chemical technology ,TP1-1185 - Abstract
Palm oil is known to be rich in carotenoids and other phytonutrients. However, the carotenoids and phytonutrients degrade due to high heat sterilization of oil palm fruits. The present study was conducted to produce carotenoid-rich virgin palm oil (VPO) using cold-press extraction. Herein, the influence of sterilization of oil palm fresh fruits in the production of cold-pressed VPO was determined with varying sterilization temperatures, times, and amounts of palm fruits in sterilization. The experimental sterilization conditions were optimized using response surface methodology (RSM) based on the maximum VPO yield and minimum FFAs in cold-pressed VPO. The optimal sterilization experimental conditions of oil palm fruits were determined to be a sterilization temperature of 62 °C, a time of 90 min, and an amount of oil palm fruits of 8 kg. Under these experimental conditions, the maximum cold-pressed VPO yield and the minimal content of free fatty acids (FFAs) obtained were 27.94 wt.% and 1.32 wt.%, respectively. Several analytic methods were employed to determine cold-pressed VPO quality and fatty acids compositions and compared with the crude palm oil. It was found that cold-pressed VPO contains higher carotenoids (708 mg/g) and unsaturated fatty acids compared with the carotenoid (343 mg/g) and fatty acid compositions in CPO. The findings of the present study reveal that the sterilization temperature potentially influences the carotenoid and nutrient contents in VPO; therefore, the optimization of the sterilization conditions is crucial to producing carotenoid- and phytonutrient-rich VPO.
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- 2021
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159. Diffusion-Controlled Instantaneous Chemical Reaction in Single Drops
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Mehra, Anurag, primary and Venugopal, B. V., additional
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- 1994
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160. The New Delhi National Museum of Natural History
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Naqvy, A. A., primary, Venugopal, B., additional, Falk, J. H., additional, and Dierking, L. D., additional
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- 1991
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161. Mitochondrial Disorder, Diabetes Mellitus, and Findings in Three Muscles, Including the Heart.
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Bhattacharjee, M., Venugopal, B., Wong, K. T., Goto, Y.-I., and Bhattacharjee, M. B.
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MITOCHONDRIAL pathology , *DIABETES , *EYE paralysis , *CORONARY disease , *HEART biopsy , *MUSCLE physiology , *GLYCOGEN , *MITOCHONDRIAL DNA abnormalities - Abstract
The authors describe the case of a 50-year-old man with chronic progressive external ophthalmoplegia (CPEO), diabetes mellitus (DM), and coronary artery disease. The patient had no cardiac conduction abnormalities. During coronary artery bypass surgery, his heart and two skeletal muscles were biopsied. All three muscles showed ragged red fibers. The heart muscle showed significant glycogen accumulation. Analysis of mitochondrial DNA (mtDNA) showed a 5019-base-pair deletion, with no duplications. There were morphologically abnormal mitochondria in all 3 muscles, with clinically apparent difference in preservation of function. The combination of diabetes mellitus and mtDNA deletion is fortuitous, as they can be causally linked. The cardiac pathology allows speculation about the possible adaptive processes that may occur in the heart in DM. There are few reported cases with CPEO and excess glycogen in the heart. Most show deposition of fat and poorer clinical outcomes as compared to those with glycogen deposition. This observation may lend support to the hypothesis that in the myocardium, adaptive responses are mediated via changes in glucose handling, whereas alterations in fat metabolism likely represent maladaptation. [ABSTRACT FROM AUTHOR]
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- 2006
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162. Mitochondrial Disorder, Diabetes Mellitus, and Findings in Three Muscles, Including the Heart.
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Venugopal, B., Wong, K. T., Goto, Y.-I., and Bhattacharjee, M. B.
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EYE paralysis , *DIABETES , *MITOCHONDRIA , *MUSCLE diseases , *CORONARY artery bypass , *HEART - Abstract
The authors describe the case of a 50-year-old man with chronic progressive external ophthalmoplegia (CPEO), diabetes mellitus (DM), and coronary artery disease. The patient had no cardiac conduction abnormalities. During coronary artery bypass surgery, his heart and two skeletal muscles were biopsied. All three muscles showed ragged red fibers. The heart muscle showed significant glycogen accumulation. Analysis of mitochondrial DNA (mtDNA) showed a 5019obase-pair deletion, with no duplications. There were morphologically abnormal mitochondria in all 3 muscles, with clinically apparent difference in preservation of function. The combination of diabetes mellitus and mtDNA deletion is fortuitous, as they can be causally linked. The cardiac pathology allows speculation about the possible adaptive processes that may occur in the heart in DM. There are few reported cases with CPEO and excess glycogen in the heart. Most show deposition of fat and poorer clinical outcomes as compared to those with glycogen deposition. This observation may lend support to the hypothesis that in the myocardium, adaptive responses are mediated via changes in glucose handling, whereas alterations in fat metabolism likely represent maladaptation. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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- View/download PDF
163. Laparoscopic cholecystectomy in acute cholecystitis.
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Prakash, K., Jacob, G., Lekha, V., Venugopal, A., Venugopal, B., and Ramesh, H.
- Abstract
Background: In the light of laparoscopic cholecystectomy increasingly applied to all forms of cholecystitis, this study aimed at evaluating the safety of laparoscopic cholecystectomy applied to all cases of acute cholecystitis, and at determining factors associated with the risk of conversion to open cholecystectomy. Methods: The clinical, biochemical, radiologic, and operative data from 124 consecutive cases of acute cholecystitis were analyzed retrospectively to determine the complications and morbidity after operation. The data were analyzed further by univariate and multivariate analysis to identify factors associated with conversion. Results: No major bile duct injury or mortality occurred. Bile leak from the stump of the cystic duct developed in four patients. These were managed successfully by endoscopic biliary stent placement. The mean duration of hospital stay was 3.8 days in the laparoscopic group and 8.2 days in the open group. Of the 124 patients (18.5%), 23 underwent conversion to open cholecystectomy. Univariate analysis identified the following factors as associated with conversion: common duct dilation greater than 7 mm observed on ultrasound, (p < 0.05), pericholecystic collection seen on ultrasound (p < 0.0001), emphysematous cholecystitis (p < 0.01), endoscopic retrograde cholangiopancreatographic evidence of Mirizzi syndrome (p < 0.05), and pericholecystic collection at operation (p < 0.0001). On multivariate analysis, only pericholecystic collection (p < 0.015) and gallbladder wall thickness greater than 5 mm (p < 0.013) were statistically significant. Conclusions: Laparoscopic cholecystectomy for acute cholecystitis can be applied safely to all comers, offering the advantage of a shortened hospital stay. Pericholecystic collection, as observed on ultrasound, is associated with a high risk of conversion to open cholecystectomy. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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164. Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
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Durairaj Sekar, Ramalingam Krishnan, Mani Panagal, Pethanen Sivakumar, Vincent Gopinath, and Venugopal Basam
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CSCs ,Cancer stem cells ,miR-21 ,miRNAs ,RNAs ,UTR ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Irrespective of positive developments of cancer treatment, the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains mysterious. As we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21–25 nucleotides (nt) in length and they silence their target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 3′-untranslated (UTR) region and play a very important role in cancer biology. Recent evidences indicate that miR-21 is over expressed in cancer stem cells and plays a vital role in cell proliferation, apoptosis, and invasion. Even though an increased expression level of miR-21 has been observed in cancer stem cells, studies related to the role of miR-21 in cancer stem cells are limited. The main aim of this mini review is to explain the potency of miR-21 in various cancer stem cells (CSCs) and as a new target for therapeutic interventions of cancer progression.
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- 2016
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165. Recycling Waste Cotton Cloths for the Isolation of Cellulose Nanocrystals: A Sustainable Approach
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Siti Hajar Mohamed, Md. Sohrab Hossain, Mohamad Haafiz Mohamad Kassim, Mardiana Idayu Ahmad, Fatehah Mohd Omar, Venugopal Balakrishnan, Muzafar Zulkifli, and Ahmad Naim Ahmad Yahaya
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waste cotton cloths ,cellulose nanocrystals ,solid waste management ,sustainability ,supercritical CO2 ,Organic chemistry ,QD241-441 - Abstract
There is an interest in the sustainable utilization of waste cotton cloths because of their enormous volume of generation and high cellulose content. Waste cotton cloths generated are disposed of in a landfill, which causes environmental pollution and leads to the waste of useful resources. In the present study, cellulose nanocrystals (CNCs) were isolated from waste cotton cloths collected from a landfill. The waste cotton cloths collected from the landfill were sterilized and cleaned using supercritical CO2 (scCO2) technology. The cellulose was extracted from scCO2-treated waste cotton cloths using alkaline pulping and bleaching processes. Subsequently, the CNCs were isolated using the H2SO4 hydrolysis of cellulose. The isolated CNCs were analyzed to determine the morphological, chemical, thermal, and physical properties with various analytical methods, including attenuated total reflection-Fourier transform-infrared spectroscopy (ATR-FTIR), field-emission scanning electron microscopy (FE-SEM), energy-filtered transmission electron microscopy (EF-TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The results showed that the isolated CNCs had a needle-like structure with a length and diameter of 10–30 and 2–6 nm, respectively, and an aspect ratio of 5–15, respectively. Additionally, the isolated CNCs had a high crystallinity index with a good thermal stability. The findings of the present study revealed the potential of recycling waste cotton cloths to produce a value-added product.
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- 2021
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166. Triple Negative Breast Cancer: A Review of Present and Future Diagnostic Modalities
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Sylvia Annabel Dass, Kim Liu Tan, Rehasri Selva Rajan, Noor Fatmawati Mokhtar, Elis Rosliza Mohd Adzmi, Wan Faiziah Wan Abdul Rahman, Tengku Ahmad Damitri Al-Astani Tengku Din, and Venugopal Balakrishnan
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triple negative breast cancer ,future diagnosis ,breast cancer ,Medicine (General) ,R5-920 - Abstract
Triple-negative breast cancer (TNBC) is an aggressive breast type of cancer with no expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2). It is a highly metastasized, heterogeneous disease that accounts for 10–15% of total breast cancer cases with a poor prognosis and high relapse rate within five years after treatment compared to non-TNBC cases. The diagnostic and subtyping of TNBC tumors are essential to determine the treatment alternatives and establish personalized, targeted medications for every TNBC individual. Currently, TNBC is diagnosed via a two-step procedure of imaging and immunohistochemistry (IHC), which are operator-dependent and potentially time-consuming. Therefore, there is a crucial need for the development of rapid and advanced technologies to enhance the diagnostic efficiency of TNBC. This review discusses the overview of breast cancer with emphasis on TNBC subtypes and the current diagnostic approaches of TNBC along with its challenges. Most importantly, we have presented several promising strategies that can be utilized as future TNBC diagnostic modalities and simultaneously enhance the efficacy of TNBC diagnostic.
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- 2021
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167. Isolation and Characterization of Magnetic Oil Palm Empty Fruits Bunch Cellulose Nanofiber Composite as a Bio-Sorbent for Cu(II) and Cr(VI) Removal
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Aina Mardhia Khalid, Md. Sohrab Hossain, Norli Ismail, Nor Afifah Khalil, Venugopal Balakrishnan, Muzafar Zulkifli, and Ahmad Naim Ahmad Yahaya
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magnetic bio-sorbent ,heavy metals adsorption ,cellulose nanofiber ,isotherm modelling ,kinetics studies ,Organic chemistry ,QD241-441 - Abstract
In the present study, magnetic oil palm empty fruits bunch cellulose nanofiber (M-OPEFB-CNF) composite was isolated by sol-gel method using cellulose nanofiber (CNF) obtained from oil palm empty fruits bunch (OPEFB) and Fe3O4 as magnetite. Several analytical methods were utilized to characterize the mechanical, chemical, thermal, and morphological properties of the isolated CNF and M-OPEFB-CNF. Subsequently, the isolated M-OPEFB-CNF composite was utilized for the adsorption of Cr(VI) and Cu(II) from aqueous solution with varying parameters, such as pH, adsorbent doses, treatment time, and temperature. Results showed that the M-OPEFB-CNF as an effective bio-sorbent for the removal of Cu(II) and Cr(VI) from aqueous solution. The adsorption isotherm modeling revealed that the Freundlich equation better describes the adsorption of Cu(II) and Cr(VI) on M-OPEFB-CNF composite. The kinetics studies revealed the pseudo-second-order kinetics model was a better-described kinetics model for the removal of Cu(II) and Cr(VI) using M-OPEFB-CNF composite as bio-sorbent. The findings of the present study showed that the M-OPEFB-CNF composite has the potential to be utilized as a bio-sorbent for heavy metals removal.
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- 2020
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168. Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma.
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Choueiri, T. K., Powles, T., Peltola, K., de Velasco, G., Burotto, M., Suarez, C., Ghatalia, P., Iacovelli, R., Lam, E. T., Verzoni, E., Gümüş, M., Stadler, W. M., Kollmannsberger, C., Melichar, B., Venugopal, B., Gross-Goupil, M., Poprach, A., De Santis, M., Schutz, F. A., and Park, S. H.
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EVEROLIMUS , *POISONS , *OVERALL survival , *PROGRESSION-free survival , *IMMUNE checkpoint proteins - Abstract
Background: Belzutifan, a hypoxia-inducible factor 2a inhibitor, showed clinical activity in clear-cell renal-cell carcinoma in early-phase studies. Methods: In a phase 3, multicenter, open-label, active-controlled trial, we enrolled participants with advanced clear-cell renal-cell carcinoma who had previously received immune checkpoint and antiangiogenic therapies and randomly assigned them, in a 1:1 ratio, to receive 120 mg of belzutifan or 10 mg of everolimus orally once daily until disease progression or unacceptable toxic effects occurred. The dual primary end points were progression-free survival and overall survival. The key secondary end point was the occurrence of an objective response (a confirmed complete or partial response). Results: A total of 374 participants were assigned to belzutifan, and 372 to everolimus. At the first interim analysis (median follow-up, 18.4 months), the median progression-free survival was 5.6 months in both groups; at 18 months, 24.0% of the participants in the belzutifan group and 8.3% in the everolimus group were alive and free of progression (two-sided P = 0.002, which met the prespecified significance criterion). A confirmed objective response occurred in 21.9% of the participants (95% confidence interval [CI], 17.8 to 26.5) in the belzutifan group and in 3.5% (95% CI, 1.9 to 5.9) in the everolimus group (P<0.001, which met the prespecified significance criterion). At the second interim analysis (median follow-up, 25.7 months), the median overall survival was 21.4 months in the belzutifan group and 18.1 months in the everolimus group; at 18 months, 55.2% and 50.6% of the participants, respectively, were alive (hazard ratio for death, 0.88; 95% CI, 0.73 to 1.07; two-sided P = 0.20, which did not meet the prespecified significance criterion). Grade 3 or higher adverse events of any cause occurred in 61.8% of the participants in the belzutifan group (grade 5 in 3.5%) and in 62.5% in the everolimus group (grade 5 in 5.3%). Adverse events led to discontinuation of treatment in 5.9% and 14.7% of the participants, respectively. Conclusions: Belzutifan showed a significant benefit over everolimus with respect to progression-free survival and objective response in participants with advanced clear-cell renal-cell carcinoma who had previously received immune checkpoint and antiangiogenic therapies. Belzutifan was associated with no new safety signals. (Funded by Merck Sharp and Dohme, a subsidiary of Merck; LITESPARK-005 ClinicalTrials.gov number, NCT04195750.). [ABSTRACT FROM AUTHOR]
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- 2024
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169. A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications
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H.P.S. Abdul Khalil, A.S. Adnan, Esam Bashir Yahya, N.G. Olaiya, Safrida Safrida, Md. Sohrab Hossain, Venugopal Balakrishnan, Deepu A. Gopakumar, C.K. Abdullah, A.A. Oyekanmi, and Daniel Pasquini
- Subjects
cellulose ,nanofibre ,aerogel ,sustainable ,biomedical applications ,Organic chemistry ,QD241-441 - Abstract
Cellulose nanomaterials from plant fibre provide various potential applications (i.e., biomedical, automotive, packaging, etc.). The biomedical application of nanocellulose isolated from plant fibre, which is a carbohydrate-based source, is very viable in the 21st century. The essential characteristics of plant fibre-based nanocellulose, which include its molecular, tensile and mechanical properties, as well as its biodegradability potential, have been widely explored for functional materials in the preparation of aerogel. Plant cellulose nano fibre (CNF)-based aerogels are novel functional materials that have attracted remarkable interest. In recent years, CNF aerogel has been extensively used in the biomedical field due to its biocompatibility, renewability and biodegradability. The effective surface area of CNFs influences broad applications in biological and medical studies such as sustainable antibiotic delivery for wound healing, the preparation of scaffolds for tissue cultures, the development of drug delivery systems, biosensing and an antimicrobial film for wound healing. Many researchers have a growing interest in using CNF-based aerogels in the mentioned applications. The application of cellulose-based materials is widely reported in the literature. However, only a few studies discuss the potential of cellulose nanofibre aerogel in detail. The potential applications of CNF aerogel include composites, organic–inorganic hybrids, gels, foams, aerogels/xerogels, coatings and nano-paper, bioactive and wound dressing materials and bioconversion. The potential applications of CNF have rarely been a subject of extensive review. Thus, extensive studies to develop materials with cheaper and better properties, high prospects and effectiveness for many applications are the focus of the present work. The present review focuses on the evolution of aerogels via characterisation studies on the isolation of CNF-based aerogels. The study concludes with a description of the potential and challenges of developing sustainable materials for biomedical applications.
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- 2020
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170. Exploring NIR Aza-BODIPY-Based Polarity Sensitive Probes with ON-and-OFF Fluorescence Switching in Pluronic Nanoparticles
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Bahar Saremi, Venugopal Bandi, Shahrzad Kazemi, Yi Hong, Francis D’Souza, and Baohong Yuan
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aza-bodipy ,environment-sensitive ,polarity-sensitive ,near-infrared fluorescence imaging ,temperature-sensitive ,ultrasound switchable fluorescence probe ,pluronic ,f-127 ,f-96 ,f-68 ,thermosensitive ,Organic chemistry ,QD241-441 - Abstract
Because of their deep penetration capability in tissue, red or near infrared (NIR) fluorophores attract much attention in bio-optical imaging. Among these fluorophores, the ones that respond to the immediate microenvironment (i.e., temperature, polarity, pH, viscosity, hypoxia, etc.) are highly desirable. We studied the response of six NIR aza-BODIPY-based and structurally similar fluorophores to polarity and viscosity for incorporation inside Pluronic nanoparticles as switchable fluorescent probes (SFPs). Based on our results, all of these fluorophores were moderately to strongly sensitive to the polarity of the microenvironment. We concluded that attaching amine groups to the fluorophore is not necessary for having strong polarity sensitive probes. We further studied the response of the fluorophores when embedded inside Pluronic nanoparticles and found that four of them qualified as SFPs. We also found that the switching ratio of the fluorophore-encapsulated Pluronic nanoparticles (ION-to-IOFF) is related to the length of the hydrophobic chain of the Pluronic tri-block copolymers. As such, the highest switching ratio pertained to F-68 with the lowest hydrophobic block poly (propylene oxide) (PPO chain of only 30 units).
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- 2020
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171. ISOLATION AND QUANTIFICATION OF LSH* AND THE EVALUATION OF RELATED SERUM BASIC PROTEINS IN NORMAL ADULTS AND CANCER PATIENTS.
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Luckey, T. D. and Venugopal, B.
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- 1975
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172. High-Output Heart Failure Contributing to Recurrent Epistaxis Kiesselbach Area Syndrome in a Patient With Hereditary Hemorrhagic Telangiectasia
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Venugopal Brijmohan Bhattad MD, Jennifer N. Bowman BA, Hemang B. Panchal MD, MPH, and Timir K. Paul MD, PhD
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Medicine (General) ,R5-920 ,Pathology ,RB1-214 - Abstract
Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare genetic blood disorder that leads to abnormal bleeding due to absent capillaries and multiple abnormal blood vessels known as arteriovenous malformations. A feature of HHT is high-output heart failure due to multiple arteriovenous malformations. High-output heart failure can lead to recurrent epistaxis Kiesselbach area syndrome (REKAS), further exacerbating heart failure through increased blood loss and resultant anemia. We report a patient with HHT who presented with high-output heart failure contributing to REKAS. In patients with REKAS, we propose if anemia is present, REKAS can be avoided by correcting the anemia by increasing the hemoglobin level to greater than 9 to 10 g/dL. This decreases hyperdynamic circulation and reduces pressure in the blood vessels of the nose.
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- 2017
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173. Key Molecular Events in Cervical Cancer Development
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Shandra Devi Balasubramaniam, Venugopal Balakrishnan, Chern Ein Oon, and Gurjeet Kaur
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cervical cancer ,cervical intraepithelial neoplasia ,human papillomavirus ,carcinogenesis ,viral oncoprotein ,tumour suppressor gene ,Medicine (General) ,R5-920 - Abstract
Cervical cancer is the fourth most common cancer among women. Infection by high-risk human papillomavirus (HPV) is the main aetiology for the development of cervical cancer. Infection by high-risk human papillomavirus (HPV) and the integration of the HPV genome into the host chromosome of cervical epithelial cells are key early events in the neoplastic progression of cervical lesions. The viral oncoproteins, mainly E6 and E7, are responsible for the initial changes in epithelial cells. The viral proteins inactivate two main tumour suppressor proteins, p53, and retinoblastoma (pRb). Inactivation of these host proteins disrupts both the DNA repair mechanisms and apoptosis, leading to rapid cell proliferation. Multiple genes involved in DNA repair, cell proliferation, growth factor activity, angiogenesis, as well as mitogenesis genes become highly expressed in cervical intraepithelial neoplasia (CIN) and cancer. This genomic instability encourages HPV-infected cells to progress towards invasive carcinoma. The key molecular events involved in cervical carcinogenesis will be discussed in this review.
- Published
- 2019
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174. pT, A new classification system for toxic compounds
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Luckey, T. D. and Venugopal, B.
- Abstract
The use of pT, the reciprocal of the logarithm of the molar concentration of harmful compounds, allows a simple, quantitative expression of the potential for toxicity of a wide variety of compounds on a molar basis. Comparison of representative toxic compounds gives a valuable perspective on some chemical hazards shared by the biomedical community and society.
- Published
- 1977
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175. Lanthanide Markers in a Single Sample for Nutrient Studies in Humans
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Hutcheson, David P., Venugopal, B., Gray, Donald H., and Luckey, Thomas
- Abstract
Multiple Lanthanide markers were used to develop procedures for determinations of intake and apparent utilization of four nutrients using data from fecal analysis and known concentrations of markers in nutrients. Terbium oxide was given as the intake marker. All foods contained the other non-absorbed markers, each marker in direct proportion to the amount of a specific nutrient in each food. Nutrient markers were oxides of samarium, scandium, ytterbium, and europium. Fecal collection and subsequent analysis of nutrients and markers were completed. Fecal marker concentration stabilized 2 days following initiation of the marker regime. Thus, after 3 days, a single grab sample could be utilized to analyze for nutrient utilization. The ratio of nutrient marker proportional to nutrient and intake to nutrient excretion provides the data for the calculation of apparent utilization for as many nutrients as nutrient markers incorporated into the food. When direct and marker method of determining nutrient intake and apparent utilization were compared, no significant differences were found for gross energy, fat, protein, and calcium.
- Published
- 1979
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176. Studies of Nutritional Safety of Some Heavy Metals in Mice
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Hutcheson, David P., Gray, Donald H., Venugopal, B., and Luckey, Thomas D.
- Abstract
Heavy metals have been proposed as nutrient markers to allow the accurate determinations of the time of passage, nutrient intake, or apparent utilization of multiple nutrients. In order to evaluate possible toxic effects of scandium, chromium, lanthanum, samarium, europium, dysprosium, terbium, thulium, and ytterbium oxides, and barium sulfate upon growth, general development, reproduction, and lactation, mice were fed different levels of these compounds for three generations. The amounts of elements fed were 0, 1, 10, 100, and 1,000 times the use amount. The use amounts were (in ppm): Sc, 0.12; Cr, 0.02; La, 0.40; Sm, 0.80; Eu, 0.036; Tb, 1.20; Dy, 1.20; Tm, 0.08; Yb, 0.12; and Ba, 0.008. The use amount was one-fifth of the concentration required for activation analysis. Mortality and morbidity were negligible. No consistent growth rate changes were observed; however, different groups showed different growth rates during different generations. The number of mice born showed no significant differences among treatment groups. Survival, growth rate, hematology, morphological development, maturation, reproduction, and lactational performance were comparable in mice fed the different levels of 10 heavy metal oxides to those mice fed the basal diet.
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- 1975
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177. Potato pyrophosphatases
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Naganna, B., Raman, A., Venugopal, B., and Sripathi, C. E.
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- 1955
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178. Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma.
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Choueiri, T. K., Tomczak, P., Park, S. H., Venugopal, B., Ferguson, T., Symeonides, S. N., Hajek, J., Chang, Y.-H., Lee, J.-L., Sarwar, N., Haas, N. B., Gurney, H., Sawrycki, P., Mahave, M., Zhang, T., Gross-Goupil, M., Burke, J. M., Doshi, G., Melichar, B., and Kopyltsov, E.
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OVERALL survival , *PEMBROLIZUMAB , *POISONS , *PROGRESSION-free survival , *CARCINOMA - Abstract
BACKGROUND Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 trial. Whether the results regarding overall survival from the third prespecified interim analysis of the trial would also favor pembrolizumab was uncertain. METHODS In this phase 3, double-blind, placebo-controlled trial, we randomly assigned (in a 1:1 ratio) participants with clear-cell renal-cell carcinoma who had an increased risk of recurrence after surgery to receive pembrolizumab (at a dose of 200 mg) or placebo every 3 weeks for up to 17 cycles (approximately 1 year) or until recurrence, the occurrence of unacceptable toxic effects, or withdrawal of consent. A significant improvement in disease-free survival according to investigator assessment (the primary end point) was shown previously. Overall survival was the key secondary end point. Safety was a secondary end point. RESULTS A total of 496 participants were assigned to receive pembrolizumab and 498 to receive placebo. As of September 15, 2023, the median follow-up was 57.2 months. The disease-free survival benefit was consistent with that in previous analyses (hazard ratio for recurrence or death, 0.72; 95% confidence interval [CI], 0.59 to 0.87). A significant improvement in overall survival was observed with pembrolizumab as compared with placebo (hazard ratio for death, 0.62; 95% CI, 0.44 to 0.87; P = 0.005). The estimated overall survival at 48 months was 91.2% in the pembrolizumab group, as compared with 86.0% in the placebo group; the benefit was consistent across key subgroups. Pembrolizumab was associated with a higher incidence of serious adverse events of any cause (20.7%, vs. 11.5% with placebo) and of grade 3 or 4 adverse events related to pembrolizumab or placebo (18.6% vs. 1.2%). No deaths were attributed to pembrolizumab therapy. CONCLUSIONS Adjuvant pembrolizumab was associated with a significant and clinically meaningful improvement in overall survival, as compared with placebo, among participants with clear-cell renal-cell carcinoma at increased risk for recurrence after surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
179. High-Resolution Ultrasound-Switchable Fluorescence Imaging in Centimeter-Deep Tissue Phantoms with High Signal-To-Noise Ratio and High Sensitivity via Novel Contrast Agents.
- Author
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Bingbing Cheng, Venugopal Bandi, Ming-Yuan Wei, Yanbo Pei, Francis D'Souza, Kytai T Nguyen, Yi Hong, and Baohong Yuan
- Subjects
Medicine ,Science - Abstract
For many years, investigators have sought after high-resolution fluorescence imaging in centimeter-deep tissue because many interesting in vivo phenomena-such as the presence of immune system cells, tumor angiogenesis, and metastasis-may be located deep in tissue. Previously, we developed a new imaging technique to achieve high spatial resolution in sub-centimeter deep tissue phantoms named continuous-wave ultrasound-switchable fluorescence (CW-USF). The principle is to use a focused ultrasound wave to externally and locally switch on and off the fluorophore emission from a small volume (close to ultrasound focal volume). By making improvements in three aspects of this technique: excellent near-infrared USF contrast agents, a sensitive frequency-domain USF imaging system, and an effective signal processing algorithm, for the first time this study has achieved high spatial resolution (~ 900 μm) in 3-centimeter-deep tissue phantoms with high signal-to-noise ratio (SNR) and high sensitivity (3.4 picomoles of fluorophore in a volume of 68 nanoliters can be detected). We have achieved these results in both tissue-mimic phantoms and porcine muscle tissues. We have also demonstrated multi-color USF to image and distinguish two fluorophores with different wavelengths, which might be very useful for simultaneously imaging of multiple targets and observing their interactions in the future. This work has opened the door for future studies of high-resolution centimeter-deep tissue fluorescence imaging.
- Published
- 2016
- Full Text
- View/download PDF
180. 893PCabozantinib in metastatic renal cell carcinoma (mRCC): Data from UK expanded access program (EAP).
- Author
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Lista, A Gomez de Liano, Venugopal, B, Fife, K, Symeonides, S, Vasudev, N S, Rudman, S M, Vohra, S, Khasati, L, Pettinger, C, and Szabados, B
- Subjects
- *
RENAL cell carcinoma , *INTERMEDIATE goods - Published
- 2018
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181. Patterns of Orthographic Working Memory Impairments in Acquired Dysgraphia in Adults: A Case Series analysis
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VENUGOPAL BALASUBRAMANIAN
- Subjects
Aphasia ,Neuropsychology ,Stroke ,dysgraphia ,orthographic working memory ,Psychology ,BF1-990 - Abstract
Introduction Studies reporting on the occurrence of orthographic working memory (OWM) impairment in cognitive neuropsychology (CN) appear to be limited. However, a recent study offers some evidence that points to the common occurrence of OWM impairments in clinical populations (Haslam, Kay, Tree, & Barron, 2009). But the evidence offered in this study is also limited to three cases with dementia. Thus, the evidence for common occurrence of OWM impairments awaits, at the least, a case series analysis of several cases. Previous studies of OWM impairments in dysraphias have identified characteristic error profile that included length effect, letter errors, and lack of frequency effects (Buchwald & Rapp, 2009). Additionally, letter errors were more common in the middle of words than in the initial or final positions (Zazio, Cappaso, & Miceli, 2013). As the recent debates on case series investigations in CN imply (Schwartz & Dell, 2010; Rapp, 2011), focused cognitive analysis of OWM impairments might reveal the trends and variations in the patterns of occurrence. The present study reports on OWM impairments in four cases with a history of chronic aphasia and dysgraphia. In addition, this study also discusses the variability in the patterns of OWM impairment and reflects on the previously established profiles of impairments. Method Subjects. Four adults with chronic aphasia have served as the subjects of this study: Subject 1:CBH, a 59-year-old, right-handed female with a medical history of stroke-induced bilateral parietal lobe lesion, Subject 2: JL, a 66-year-old, right-handed female with an ischemic stroke affecting posterior temporo-parietal cortex of the left hemisphere and bilateral white matter atrophy, Subject 3: LK, a 45-year old, right-handed male with a stroke induced infarct involving the left temporal region and a portion of the left frontal cortex, and Subject 4: SE, a 69-year-old right-handed female, with a stroke-induced lesion in the right frontal lobe under the anterior horn of the lateral ventricle and the head of caudate and putamen. Procedure Clinical evaluation included administration of the Boston Diagnostic Aphasia Examination (BDAE). Experimental Tests administered include 1) Johns Hopkins University Dysgraphia Battery and 2) Psycholinguistic Assessment of Language Performance in Aphasia (PALPA), specifically the letter length subtests of Reading and Spelling Tests. Results and Discussion The results revealed the presence of letter length effect in all four patients: LK had 17% correct responses, JL had 30% correct responses, CBH had 79% correct responses, and SE had 87% correct responses. These results clearly support the view of common occurrence of OWM impairments (Haslam, Kay, Tree, & Baron, 2009). However, there was a variable letter position pattern in the four patients (Figure 1). SE, who had the least number of errors, among the four patients, was the only case that had a clear bow-shaped pattern. CBH had more errors in the middle letters but did not show a clear bow-shaped pattern. LK and JL had more errors in the initial letters than in the succeeding ones. These findings warrant further research into the importance of letter position for the characterization of OWM impairment profile.
- Published
- 2015
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182. Ribotyping identification of Escherichia coli producing temperature-labile helicase
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Sundram, Y., Asma, I., Venugopal, B., Ong, E., and Sreenivasan Sasidharan
183. Lysosomal proteinases in muscle tissue and leukocytes of meat animals
- Author
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Venugopal, B., primary and Bailey, M.E., additional
- Published
- 1978
- Full Text
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184. A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging
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Jayanth Kandukuri, Shuai Yu, Bingbing Cheng, Venugopal Bandi, Francis D’Souza, Kytai T. Nguyen, Yi Hong, and Baohong Yuan
- Subjects
ultrasound-switchable fluorescence imaging ,ultrasound imaging ,dual-modality imaging ,multi-color fluorescence imaging ,deep-tissue fluorescence imaging ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90°-crossed ultrasound transducers with an overlapped focal region, while the US transducer (the third one) was positioned at the center of these two USF transducers. Thus, the axial resolution of USF is close to the lateral resolution, which allows a point-by-point USF scanning on the same plane as the US imaging. Both multi-color USF and ultrasound imaging of a tissue phantom were demonstrated.
- Published
- 2017
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185. The Mechanisms and Biomedical Applications of an NIR BODIPY-Based Switchable Fluorescent Probe
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Bingbing Cheng, Venugopal Bandi, Shuai Yu, Francis D’Souza, Kytai T. Nguyen, Yi Hong, Liping Tang, and Baohong Yuan
- Subjects
aza-BODIPY ,environment-sensitive fluorophore ,switchable fluorescent probe ,near-infrared ,wash-free live-cell imaging ,in vivo fluorescence imaging ,temperature sensing ,USF imaging ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Highly environment-sensitive fluorophores have been desired for many biomedical applications. Because of the noninvasive operation, high sensitivity, and high specificity to the microenvironment change, they can be used as excellent probes for fluorescence sensing/imaging, cell tracking/imaging, molecular imaging for cancer, and so on (i.e., polarity, viscosity, temperature, or pH measurement). In this work, investigations of the switching mechanism of a recently reported near-infrared environment-sensitive fluorophore, ADP(CA)2, were conducted. Besides, multiple potential biomedical applications of this switchable fluorescent probe have been demonstrated, including wash-free live-cell fluorescence imaging, in vivo tissue fluorescence imaging, temperature sensing, and ultrasound-switchable fluorescence (USF) imaging. The fluorescence of the ADP(CA)2 is extremely sensitive to the microenvironment, especially polarity and viscosity. Our investigations showed that the fluorescence of ADP(CA)2 can be switched on by low polarity, high viscosity, or the presence of protein and surfactants. In wash-free live-cell imaging, the fluorescence of ADP(CA)2 inside cells was found much brighter than the dye-containing medium and was retained for at least two days. In all of the fluorescence imaging applications conducted in this study, high target-to-noise (>5-fold) was achieved. In addition, a high temperature sensitivity (73-fold per Celsius degree) of ADP(CA)2-based temperature probes was found in temperature sensing.
- Published
- 2017
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186. Occurrence of alkaline pyrophosphatase in vegetable tissues
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Naganna, B., primary, Venugopal, B., additional, and Sripathi, C. E., additional
- Published
- 1955
- Full Text
- View/download PDF
187. Genotyping of Toxoplasma gondii isolates from wild boars in Peninsular Malaysia.
- Author
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Vignesh R Puvanesuaran, Rahmah Noordin, and Venugopal Balakrishnan
- Subjects
Medicine ,Science - Abstract
Toxoplasma gondii is a parasitic protozoan that infects nearly one-third of the world population. The present study was done to isolate and genotype T. gondii from wild boar from forests of Pahang, Malaysia. A total of 30 wild boars' blood, heads and hearts were obtained for this study and 30 (100.0%) were found to be seropositive when assayed with modified agglutination test (MAT ≥ 6). The positive samples were inoculated into mice and T. gondii was only isolated from samples that had strong seropositivity (MAT ≥ 1:24).The isolates were subjected to PCR-RFLP analysis and all the Peninsular Malaysia isolates of T. gondii are of clonal type I.
- Published
- 2013
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- View/download PDF
188. Textiles in Agriculture.
- Author
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Gopalakrishnan, D., Venugopal, B., and Rajkumar, A.
- Abstract
The article discusses the role of and requirements for textiles used in agriculture. "Agrotextile" use includes protecting plants and crops from weather, weeds, and birds. Agrotextiles need to be weather-resistant and impervious to micro-organisms. Depending on application, biodegradability and the ability to retain water are desirable features as well.
- Published
- 2007
189. Design and realization challenges of power supplies for space TWT.
- Author
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Bijeev, N.V., Malhotra, A., Kumar, V., Singh, S., Dasgupta, K.S., Motta, R.N., Venugopal, B., Sandhyarani, Jinan, O.K., and Jayakumar, B.K.
- Published
- 2011
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190. Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer.
- Author
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Freedland, S. J., Almeida Luz, M. de, Giorgi, U. De, Gleave, M., Gotto, G. T., Pieczonka, C. M., Haas, G. P., Kim, C.-S., Ramirez-Backhaus, M., Rannikko, A., Tarazi, J., Sridharan, S., Sugg, J., Tang, Y., Tutrone Jr., R. F., Venugopal, B., Villers, A., Woo, H. H., Zohren, F., and Shore, N. D.
- Subjects
- *
CLINICAL trials , *PROSTATE cancer , *PROSTATE cancer patients , *LEUPROLIDE , *PROSTATE-specific antigen - Abstract
BACKGROUND Patients with prostate cancer who have high-risk biochemical recurrence have an increased risk of progression. The efficacy and safety of enzalutamide plus an- drogen-deprivation therapy and enzalutamide monotherapy, as compared with androgen-deprivation therapy alone, are unknown. METHODS In this phase 3 trial, we enrolled patients with prostate cancer who had high-risk biochemical recurrence with a prostate-specific antigen doubling time of 9 months or less. Patients were randomly assigned, in a 1:1:1 ratio, to receive enzalutamide (160 mg) daily plus leuprolide every 12 weeks (combination group), placebo plus leuprolide (leuprolide-alone group), or enzalutamide monotherapy (monotherapy group). The primary end point was metastasis-free survival, as assessed by blinded independent central review, in the combination group as compared with the leu- prolide-alone group. A key secondary end point was metastasis-free survival in the monotherapy group as compared with the leuprolide-alone group. Other secondary end points were patient-reported outcomes and safety. RESULTS A total of 1068 patients underwent randomization: 355 were assigned to the com- bination group, 358 to the leuprolide-alone group, and 355 to the monotherapy group. The patients were followed for a median of 60.7 months. At 5 years, metastasis-free survival was 87.3% (95% confidence interval [CI], 83.0 to 90.6) in the combination group, 71.4% (95% CI, 65.7 to 76.3) in the leuprolide-alone group, and 80.0% (95% CI, 75.0 to 84.1) in the monotherapy group. With respect to metastasis-free survival, enzalutamide plus leuprolide was superior to leuprolide alone (hazard ratio for metastasis or death, 0.42; 95% CI, 0.30 to 0.61; P<0.001); enzalutamide monotherapy was also superior to leuprolide alone (hazard ratio for metastasis or death, 0.63; 95% CI, 0.46 to 0.87; P=0.005). No new safety signals were observed, with no substantial between-group differences in quality-of-life measures. CONCLUSIONS In patients with prostate cancer with high-risk biochemical recurrence, enzalutamide plus leuprolide was superior to leuprolide alone with respect to metastasis- free survival; enzalutamide monotherapy was also superior to leuprolide alone. The safety profile of enzalutamide was consistent with that shown in previous clinical studies, with no apparent detrimental effect on quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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191. Ecological awareness and current developments in wet processing of textiles in India.
- Author
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Venugopal, B. R.
- Abstract
The article reports on the ecological awareness of textile industries in India. Ecological awareness is considered a new development in the various countries. The use of environment friendly dyes and chemicals were also implemented in wet processing units. Research and test programs were also taken to identify the effect of toxic and non-toxic dyes and chemicals on the health of the people.
- Published
- 1995
192. ACTIVITY PATTERN OF INDIAN RHINO IN MYSORE ZOO.
- Author
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Venugopal, B., Shanker, R. Shiva, Deepak, J. C., Lakshminarayana, M. S., and Naik, Sunil
- Published
- 1994
193. VISITOR BEHAVIOR (TEASING) AT THE ASIATIC LION ENCLOSURE IN THE MYSORE ZOO.
- Author
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Raju, R. and Venugopal, B.
- Published
- 1994
194. Visitor Behavior at Lion-Tailed Macaque In the Mysore Zoo.
- Author
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Venugopal, B. and Sha, A. Akbar
- Published
- 1993
195. LBA74 Final analysis of the phase III LITESPARK-005 study of belzutifan versus everolimus in participants (pts) with previously treated advanced clear cell renal cell carcinoma (ccRCC).
- Author
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Rini, B.I., Suarez Rodriguez, C., Albiges, L., Jalkanen, K., De Velasco Oria, G.A., Burotto, M., Ghatalia, P., Iacovelli, R., Lam, E.T., Verzoni, E., Gumus, M., Stadler, W., Kollmannsberger, C.K., Melichar, B., Venugopal, B., Lin, J., Perini, R., Vickery, D., Choueiri, T.K., and Powles, T.B.
- Subjects
- *
RENAL cell carcinoma , *EVEROLIMUS - Published
- 2024
- Full Text
- View/download PDF
196. Gen Y makes up the bulk of our workforc.
- Author
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Venugopal, B.
- Subjects
EMPLOYEE recruitment ,EMPLOYMENT practices ,TALENT management ,BUSINESS success - Abstract
The article focuses on the approach of Molecular Connections in the recruitment of employees. It is inferred that majority of the workforce at Molecular Connections belong to Generation Y or the millennials. According to the author, hiring the right freshers is essential to the success of the business.
- Published
- 2013
197. Immune reconstitution inflammatory syndrome (IRIS) in HIV positive patients initiated on antiretroviral therapy (ART).
- Author
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Achappa, Basavaprabhu, Unnikrishnan, Deepak Madi, and Venugopal, B. Anand
- Subjects
IMMUNE reconstitution inflammatory syndrome ,HIV-positive persons - Abstract
An abstract of the article "Immune reconstitution inflammatory syndrome (IRIS) in HIV positive patients initiated on antiretroviral therapy (ART)," by Basavaprabhu Achappa, Deepak Madi Unnikrishnan, and B. Anand Venugopal is presented.
- Published
- 2012
- Full Text
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198. Biliary access loops for intrahepatic stones: results of jejunoduodenal anastomosis.
- Author
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Ramesh, Hariharan, Prakash, Kurumboor, Kuruvilla, Kuruvilla, Philip, Mathew, Jacob, George, Venugopal, B., Lekha, V., and Varma, Deepak
- Subjects
CALCULI ,INTRAHEPATIC bile ducts - Abstract
Background: Patients with intrahepatic calculi require multiple interventions following successful surgical stone clearance for recurrent stones and cholangitis. The present paper describes the results of a technique of in-continuity side-to-side jejunoduodenal anastomosis (JDA) that provides endoscopic access to the hepaticojejunostomy and intrahepatic ducts. This operation is compared to other techniques in a critical appraisal of various biliary access procedures described for long-term management of intrahepatic calculi. Methods: A retrospective analysis of clinical data of 13 patients who underwent biliary drainage procedures with access loops for intrahepatic calculi during the period March 1990 to December 2000 was performed. The postoperative course of patients and the feasibility of postoperative endoscopic access to the hepaticojejunostomy and intrahepatic ductal system in treatment of recurrent cholangitis were assessed. Nine patients underwent JDA, two underwent permanent-access hepaticojejunostomy (PAH) and two others underwent an interposition hepaticojejunoduodenostomy (IHJ). Results: The analysis revealed no major procedure-related complications or mortality. Endoscopic access (using forward-viewing gastroscope) was possible in 100% of cases following JDA, and with difficulty in both cases after PAH. Endoscopic access in the two patients with IHJ failed because of technical reasons. Recurrent cholangitis was seen in seven patients (54%) - two out of two patients in the PAH group, one out of two in the IHJ group and four out of nine in the JDA group. This required 12 endotherapy sessions (mean: 1.5 procedures per patient). Conclusion: In-continuity side-to-side JDA allows easy access of conventional gastroduodenoscopes to the biliary tree for removal of recurrent/residual intrahepatic stones. The technique has advantages over other access loop procedures in the long term management of recurrent intrahepatic stones. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
199. 1693P CaboPoint: Final results from a phase II study of cabozantinib after checkpoint inhibitor (CPI) combinations in patients with advanced renal cell carcinoma (aRCC).
- Author
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Albiges, L., Powles, T.B., Sharma, A., Venugopal, B., Bedke, J., Borkowetz, A., Gravis, G., Özdemir, B.C., Schnabel, M.J., Dutailly, P., Qvick, B., Perrot, V., and Gruenwald, V.
- Subjects
- *
RENAL cell carcinoma - Published
- 2024
- Full Text
- View/download PDF
200. Purification of porcine leukocyte lysosomal hydrolases
- Author
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Venugopal, B. and Bailey, M. E.
- Published
- 1978
- Full Text
- View/download PDF
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