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151. Discrimination, stigma and mental health: what’s next?

Author

Torales, Julio, primary, Aveiro-Róbalo, Telmo Raúl, additional, Ríos-González, Carlos, additional, Barrios, Iván, additional, Almirón-Santacruz, José, additional, González-Urbieta, Israel, additional, Caycho-Rodríguez, Tomás, additional, Castaldelli-Maia, João Mauricio, additional, and Ventriglio, Antonio, additional

Published
2023
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152. “Pandemic Fatigue” in South America: A Multi-Center Report from Argentina, Bolivia, Paraguay, Peru, and Uruguay

Author

Torales, Julio, primary, González-Urbieta, Israel, additional, Barrios, Iván, additional, Waisman-Campos, Marcela, additional, Terrazas-Landivar, Alexandra, additional, Viola, Laura, additional, Caycho-Rodríguez, Tomás, additional, Melgarejo, Osvaldo, additional, Navarro, Rodrigo, additional, García, Oscar, additional, Almirón-Santacruz, José, additional, Castaldelli-Maia, João Mauricio, additional, and Ventriglio, Antonio, additional

Published
2023
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153. Tecnologías para la Evaluación, Diagnóstico y Tratamiento del Trastorno por Déficit de Atención e Hiperactividad: Una Revisión Preliminar e Integradora

Author

Boechi, Laura C., primary, Encina Benítez, Fátima L., additional, Rodas Jara, Ronaldo L., additional, Rodas Jara, Liza R., additional, Villagra, María del Rosario, additional, Báez, Diana, additional, Navarro, Rodrigo, additional, Almirón-Santacruz, José, additional, Barrios, Iván, additional, Castaldelli-Maia, João Mauricio, additional, Ventriglio, Antonio, additional, and Torales, Julio, additional

Published
2023
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157. Benzodiazepines and Sleep Architecture: A Systematic Review

Author

Sousa Martins Silva, Anderson, primary, de Mendonça, Felipe Maraucci Ribeiro, additional, de Mendonça, Giulia Paulo Rossi Ribeiro, additional, Souza, Laura Costa, additional, Galvão, Lucas Pequeno, additional, Paiva, Henrique Soares, additional, de Azevedo Marques Périco, Cintia, additional, Torales, Julio, additional, Ventriglio, Antonio, additional, and Maurício Castaldelli-Maia, João, additional

Published
2023
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158. Medical Students Training and Mental Health: An Exploratory Study

Author

Torales, Julio, Barrios, Iván, Barrios Coronel, Jazmín, Báez, Hernando, Sánchez Piris, Enrique, Ortigoza Alvez, Edis, Amarilla, Diego, Caycho Rodríguez, Tomás, de Estudiantes Investigadores en Neurociencias, Red, Ruiz Díaz, Noelia, O’Higgins, Marcelo, Villalba Arias, Jorge, Almirón Santacruz, José, Castaldelli Maia, João Mauricio, Ventriglio, Antonio, Torales, Julio, Barrios, Iván, Barrios Coronel, Jazmín, Báez, Hernando, Sánchez Piris, Enrique, Ortigoza Alvez, Edis, Amarilla, Diego, Caycho Rodríguez, Tomás, de Estudiantes Investigadores en Neurociencias, Red, Ruiz Díaz, Noelia, O’Higgins, Marcelo, Villalba Arias, Jorge, Almirón Santacruz, José, Castaldelli Maia, João Mauricio, and Ventriglio, Antonio

Abstract

Introduction: Medical students are vulnerable to psychological distress and face a number of stressors such as academic pressures, economic concerns, and difficulties in interpersonal relationships. The quality of their educational training may also impact their mental health and subjective well-being. Objective: to describe their perception of subjective well-being and the impact of medical training on their own mental health. Methods: We surveyed 119 medical students and administered the “Perception survey on vocation, living and recreational habits, training and professional attitudes,” the CAGE questionnaire, the Generalized Anxiety Disorder-7 (GAD-7) and the Patient Health Questionnaire-2 (PHQ-2). Results: Students’ mean age was 22.5±2.28 years old and 59.7 % of participants were women, their lifestyle habits were scored as acceptable, and the employment of cell-phones and social networks ranged 76-99%; 24.1 % recognized a problematic alcohol, 67.2 % reported anxiety according to the GAD-7, and 49.6 % depression according to PHQ-2. Symptoms of anxiety were frequent among females and were higher when the perceived quality of training and student/teacher ratio were lower. Discussion: Students’ perceptions of lower quality of training and resources seemed to be associated with higher levels of anxiety, which may suggest that educational policies and resources should be carefully revised and implemented to improve students’ health and well-being., Introducción: los estudiantes de medicina son vulnerables al malestar psicológico y se enfrentan a una serie de factores estresantes como las presiones académicas, las preocupaciones económicas y las dificultades en las relaciones interpersonales. La calidad de su formación educativa también puede influir en su salud mental y bienestar subjetivo. Este fue un estudio descriptivo, transversal y observacional que incluyó estudiantes de medicina de la Universidad Nacional de Asunción, Campus Santa Rosa del Aguaray, Paraguay, y tuvo como objetivo describir su percepción de bienestar subjetivo y el impacto de la formación médica en su propia salud mental. Metodología: se encuestó a 119 estudiantes de medicina y se les administró la "Encuesta de percepción sobre vocación, hábitos de vida y recreación, formación y actitudes profesionales", el cuestionario CAGE, el Trastorno de Ansiedad Generalizada-7 (TAG-7) y el Cuestionario de Salud del Paciente-2 (PHQ-2). Resultados: la edad media de los estudiantes fue de 22,5±2,28 años y el 59,7 % de los participantes eran mujeres; sus hábitos de vida se calificaron como aceptables, y el empleo de teléfonos móviles y redes sociales osciló entre el 76 y el 99 %; el 24,1 % reconoció un consumo problemático de alcohol, el 67,2 % manifestó ansiedad según el TAG-7, y el 49,6 % depresión según el PHQ-2. Los síntomas de ansiedad eran frecuentes entre las mujeres y eran mayores cuando la calidad percibida de la formación y la proporción alumnos/profesor eran menores. Discusión: la percepción por parte de los estudiantes de una menor calidad de la formación y de los recursos parecía estar asociada a mayores niveles de ansiedad, lo que puede sugerir que las políticas y los recursos educativos deberían revisarse y aplicarse cuidadosamente para mejorar la salud y el bienestar de los estudiantes.

Published
2023

159. Anxiety, depression, and vulnerability to stress in people diagnosed with rheumatoid arthritis: An exploratory study at the Hospital de Clínicas of the Universidad Nacional de Asunción

Author

Almirón Santacruz, José, Barrios Coronel, Iván, Rojas Loreiro, René, O’Higgins, Marcelo Gerardo, Ruiz Díaz, Noelia, Torres Romero, Anthon Daniel, Franco Di Giuseppe, Matías, Yinde Encina, Yanira, Pusineri Escobar, Paola, Castaldelli Maia, João Daniel, Ventriglio, Antonio, and Torales, Julio César

Subjects
rheumatoid arthritis, stress, estrés, artritis reumatoidea, depression, depresión, ansiedad, anxiety
Abstract

RESUMEN Antecedentes: Estudios observacionales han descrito una alta prevalencia de depresión y ansiedad en la artritis reumatoidea: los trastornos depresivos mayores se detectan en el 17 % de los pacientes con la patología, y la inflamación local y sistémica desempeña un papel importante en la ansiedad y la depresión. Objetivos: El objetivo general de esta investigación fue determinar la frecuencia de ansiedad, depresión y vulnerabilidad al estrés en pacientes con diagnóstico de artritis reumatoidea. Materiales y métodos: Este fue un estudio observacional, descriptivo de asociación cruzada y temporalmente prospectivo. El muestreo fue no probabilístico de casos consecutivos. Se incluyó a personas adultas con diagnóstico de artritis reumatoide que consultaron en el Departamento de Reumatología del Hospital de Clínicas, entre agosto y octubre del 2022. Para el diagnóstico psiquiátrico se utilizaron los siguientes instrumentos: Escala de Ansiedad Generalizada (GAD-7), Patient Health Questionnaire (PHQ-2) y Escala de Vulnerabilidad al Estrés de Smith y Miller. Resultados: Se incluyó a 36 pacientes, todas mujeres, con edades comprendidas entre los 20 y 77 años. El 27,8 % tenía depresión, según los puntos de corte del PHQ-2. El 22,2 % presentaba ansiedad, según los puntos de corte de GAD-7. En cuanto al estrés, el 22,2 % tenía vulnerabilidad a este y el 5,6 % era seriamente vulnerable. Conclusión: Depresión, ansiedad y vulnerabilidad al estrés son comorbilidades frecuentemente observadas en pacientes con artritis reumatoidea. Se requieren de intervenciones específicas de salud mental para abordar estas cuestiones y mejorar la calidad de vida de los pacientes afectados. ABSTRACT Background: Observational studies have described a high prevalence of depression and anxiety in rheumatoid arthritis: major depressive disorders are detected in 17 % of patients with the pathology, and local and systemic inflammation play an important role in anxiety and depression. Objectives: The overall objective of this research was to determine the frequency of anxiety, depression, and vulnerability to stress in patients diagnosed with rheumatoid arthritis. Materials and methods: This was an observational, descriptive, temporally prospective, cross-association study. Sampling was non-probabilistic of consecutive cases. We included adults with a diagnosis of rheumatoid arthritis who consulted at the Rheumatology Department of the Hospital de Clínicas between August and October 2022. The following instruments were used for psychiatric diagnosis: Generalized Anxiety Scale (GAD-7), Patient Health Questionnaire (PHQ-2) and Smith and Miller's Stress Vulnerability Scale. Results: Thirty-six patients, all women, aged between 20 and 77 years, were included in the study. The 27.8 % had depression, according to the cut-off points of the PHQ-2. Anxiety was present in 22.2 %, according to the GAD-7 cut-off points. Regarding stress, 22.2 % were vulnerable to stress and 5.6 % were seriously vulnerable. Conclusion: Depression, anxiety and vulnerability to stress are frequently observed comorbidities in patients with rheumatoid arthritis. Specific mental health interventions are required to address these issues and improve the quality of life of affected patients.

Published
2023

160. Self, spirituality and social psychiatry.

Author

Bhugra, Dinesh and Ventriglio, Antonio

Subjects
*PSYCHIATRY, *SPIRITUALITY, *PATIENT participation, *SOCIAL determinants of health, *SELF-perception, *ATTITUDE (Psychology), *GROUP identity, *SELF-consciousness (Awareness), *PSYCHOLOGY & religion, *SOCIAL psychology, *MENTAL illness, *RELIGION
Abstract

An editorial is presented on the intricate relationship between self, spirituality, and social psychiatry, exploring how cultural factors shape individuals' concepts of identity and self-perception. Topics include the influence of culture on self-identity, the role of spirituality in mental health, and the need for culturally sensitive approaches in psychiatric assessment and treatment. It reports that cultural meanings profoundly affect individuals' perceptions of self and spirituality.

Published
2024
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169. Major depressive disorder as a risk factor for suicidal ideation for attendees of educational institutions: a meta-analysis and meta-regression

Author

Souza, Laura Costa, primary, Galvão, Lucas Pequeno, additional, Paiva, Henrique Soares, additional, Périco, Cintia de Azevedo-Marques, additional, Ventriglio, Antonio, additional, Torales, Julio, additional, Castaldelli-Maia, João Maurício, additional, and Martins-da-Silva, Anderson Sousa, additional

Published
2023
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171. The impact of body mass index on the pregnancy outcomes and risk of perinatal depression: Findings from a multicenter Italian study

Author

Ventriglio, Antonio, primary, Severo, Melania, additional, Petito, Annamaria, additional, Nappi, Luigi, additional, Iuso, Salvatore, additional, Altamura, Mario, additional, Sannicandro, Valeria, additional, Milano, Eleonora, additional, Arcidiacono, Giulia, additional, Di Salvatore, Melanie, additional, Gallone, Fiammetta, additional, De Masi, Laura, additional, Marconcini, Alessia, additional, Giannaccari, Elisa, additional, Maruotti, Giuseppe, additional, Palma, Giuseppe Luigi, additional, Vicino, Mario, additional, Perrone, Antonio, additional, Caroli, Antonella, additional, Di Pinto, Isabella, additional, and Bellomo, Antonello, additional

Published
2023
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172. Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2)

Author

Fornaro, Michele, De Berardis, Domenico, Mazza, Monica, Pino, Mariachiara, Favaretto, Ettore, Bedani, Fulvio, Wieser, Christian, Indelicato, Luisa, Paternò, Vito Fabio, Lo Monaco, Francesca, Dugo, Febronia, Ventriglio, Antonio, Mungo, Sergio, Selle, Valerio, Valchera, Alessandro, Elassy, Mai, Martinotti, Giovanni, De Bartolomeis, Andrea, Iasevoli, Felice, Tomasetti, Carmine, Avvisati, Livia, Tartaglione, Sergio, Perna, Giampaolo, Cattaneo, Carlo Ignazio, Consoli, Giorgio, Romano, Anna, Del Debbio, Alessandro, Martino, Matteo, D׳Angelo, Emanuela, De Pasquale, Concetta, Koshy, Ann Sarah, and Angst, Jules

Published
2015
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173. Associated factors and psychometric properties of the Spanish version of the Brief Irritability Test (BITe) in Paraguayan population

Author

Barrios Coronel, Iván, primary, Almirón Santacruz, José, additional, O’Higgins, Marcelo Gerardo, additional, Ruiz Díaz, Noelia, additional, Navarro, Rodrigo Eduardo, additional, García, Oscar Enrique, additional, Melgarejo, Osvaldo José, additional, Amarilla Salvioni, Diego, additional, Torres Romero, Anthon Daniel, additional, Franco Di Giuseppe, Matías, additional, Rolón Méndez, Elías René, additional, Martínez López, Patricia Lorena, additional, Heinichen Mansfeld, Katja Victoria, additional, Castaldelli Maia, João Mauricio, additional, Ventriglio, Antonio, additional, and Torales, Julio César, additional

Published
2022
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176. Clinico-epidemiological profile of patients at children’s psychosocial care centers in São Bernardo do Campo: a cross-sectional study

Author

Messias, Maialu Pedreira, primary, Silva, Etienne de Miranda e, additional, Andrade, Mariele Hertha de, additional, Cavallo, Isabela Cristina Casanova, additional, Galvão, Lucas Pequeno, additional, Périco, Cintia de Azevedo Marques, additional, Torales, Julio, additional, Ventriglio, Antonio, additional, Castaldelli-Maia, João Mauricio, additional, and Martins-da-Silva, Anderson Sousa, additional

Published
2022
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177. Measles Induced Encephalitis: Recent Interventions to Overcome the Obstacles Encountered in the Management Amidst the COVID-19 Pandemic

Author

Diwan, Mufaddal Najmuddin, primary, Samad, Saba, additional, Mushtaq, Rabeea, additional, Aamir, Alifiya, additional, Allahuddin, Zoha, additional, Ullah, Irfan, additional, Ullah Afridi, Rifayat, additional, Ambreen, Aneela, additional, Khan, Adel, additional, Ehsan, Nimra, additional, Ehsan Khattak, Zoia, additional, Ventriglio, Antonio, additional, and De Berardis, Domenico, additional

Published
2022
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179. Food Addiction

Author

Florio, Ligia, primary, Lassi, Dângela L.S., additional, de Azevedo-Marques Perico, Cintia, additional, Vignoli, Natalia G., additional, Torales, Julio, additional, Ventriglio, Antonio, additional, and Castaldelli-Maia, João M., additional

Published
2022
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182. Association between urban/rural background and the development of depressive spectrum disorders: an experience from telepsychiatry

Author

Torales, Julio, Insaurralde, Ariel, Ríos-González, Carlos, Ruíz Díaz, Noelia, Navarro, Rodrigo, Ayala-Servín, Nicolás, Almirón-Santacruz, José, Gamarra-Vega, Edgar, Segovia-Cañete, Alejandra, Vera-Toledo, Hugo, Barrios, Iván, Castaldelli-Maia, João Mauricio, Ventriglio, Antonio, and O’Higgins, Marcelo

Subjects
población rural, urban population, depression, rural population, depresión, COVID-19, telepsychiatry, Building and Construction, Electrical and Electronic Engineering, telepsiquiatría, población urbana
Abstract

RESUMEN Introducción: una de las estrategias que se consideraron a la hora de hacer frente a los problemas de salud mental durante la pandemia de COVID-19 fue la utilización de la telepsiquiatría. Objetivo: determinar si la procedencia urbana o rural se asocia al desarrollo de trastornos depresivos en pacientes que consultan a través de telepsiquiatría en un Hospital de referencia de Paraguay. Metodología: estudio observacional, descriptivo de asociación cruzada, de corte transversal. Se realizó un muestreo no probabilístico, de casos consecutivos. Se utilizaron fichas electrónicas de pacientes tratados en el Servicio de Psiquiatría del Hospital de Clínicas de la Universidad Nacional de Asunción entre marzo y junio de 2021. Se aplicó estadística descriptiva para todas las variables. Para la comparación de grupos con variables cualitativas nominales se utilizó la prueba de Chi cuadrado, calculando el odds ratio según sexo y área de residencia, considerando una p˂0,05 como significativa. Se utilizó, además, la prueba T de Student para comparar una variable nominal con una variable cuantitativa. Resultados: se analizaron 907 fichas clínicas, encontrándose 92 pacientes con trastornos del espectro depresivo. Al analizar la asociación entre el ambiente rural y urbano con la presencia de un episodio depresivo, se encontró una asociación significativa entre el ambiente rural y el diagnóstico de un trastorno depresivo (OR=7,81, χ2=63,33, p

Published
2021

183. Compassion fatigue and healthcare professionals: Challenges.

Author

Bhugra, Dinesh and Ventriglio, Antonio

Subjects
*EMPATHY, *SERIAL publications, *PSYCHOLOGICAL burnout, *MEDICAL personnel, *DEPERSONALIZATION, *PSYCHOLOGICAL stress, *SECONDARY traumatic stress, *PSYCHOSOCIAL factors, *EMPLOYEES' workload
Abstract

An editorial focuses on the challenges of burnout and compassion fatigue among healthcare professionals, exploring their symptoms, differences, and the importance of self-care in managing these issues.

Published
2024
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184. Others, othering, otherism and social psychiatry.

Author

Bhugra, Dinesh and Ventriglio, Antonio

Subjects
*GROUP identity, *STEREOTYPES, *CULTURE, *ATTITUDE (Psychology), *CHANGE, *DISCRIMINATION (Sociology), *HEALTH equity, *SELF-perception, *LONGEVITY
Abstract

The article focuses on the concepts of identity, othering, and their implications in social psychiatry. Topics include the role of identity in individual self-perception and societal interactions, the impact of othering on discrimination and mental health, and the necessity of culturally sensitive approaches in psychiatric care to address health inequalities.

Published
2024
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189. Networks for the development of research culture at the University: Introducing the Neuroscience Research Students Network

Author

Torres Romero, Anthon Daniel, primary, Franco Di Giuseppe, Matías, additional, Rolón Méndez, Elías René, additional, Martínez López, Patricia Lorena, additional, Heinichen Mansfeld, Katja Victoria, additional, Barrios Coronel, Iván, additional, Castaldelli Maia, João Mauricio, additional, Ventriglio, Antonio, additional, and Torales, Julio César, additional

Published
2022
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192. Perinatal depression screening and prevention: Descriptive findings from a multicentric program in the South of Italy

Author

Bellomo, Antonello, primary, Severo, Melania, additional, Petito, Annamaria, additional, Nappi, Luigi, additional, Iuso, Salvatore, additional, Altamura, Mario, additional, Marconcini, Alessia, additional, Giannaccari, Elisa, additional, Maruotti, Giuseppe, additional, Palma, Giuseppe Luigi, additional, Vicino, Mario, additional, Perrone, Antonio, additional, Tufariello, Anna Maria, additional, Sannicandro, Valeria, additional, Milano, Eleonora, additional, Arcidiacono, Giulia, additional, Di Salvatore, Melanie, additional, Caroli, Antonella, additional, Di Pinto, Isabella, additional, and Ventriglio, Antonio, additional

Published
2022
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193. Issues Faced by General Practitioners in Managing Mental Health Disorders in Basic Health Units: a Cross-Sectional Study

Author

Moreira E Silva, Célia Regina, primary, Pinheiro de Almeida, Ana Paula, additional, Pequeno Galvão, Lucas, additional, Paiva, Henrique Soares, additional, Butinhon, Mariana Vendramini, additional, Marques Périco, Cintia De Azevedo, additional, Torales, Julio, additional, Ventriglio, Antonio, additional, Castaldelli-Maia, João M., additional, and Martins Silva, Anderson Sousa, additional

Published
2022
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194. Atopic dermatitis in psychodermatology: a concise review for dermatologists

Author

TORALES, Julio, primary, MALVIDO, Karina, additional, SANTOS-MUÑOZ, Andrea, additional, GONZALEZ-URBIETA, Israel, additional, BARRIOS, Iván, additional, ALMIRÓN-SANTACRUZ, José, additional, GARCÍA, Oscar, additional, CASTALDELLI-MAIA, João M., additional, VENTRIGLIO, Antonio, additional, and O’HIGGINS, Marcelo, additional

Published
2022
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197. Self-harm and suicidality among LGBTIQ people: a systematic review and meta-analysis

Author

Marchi, Mattia, Arcolin, Elisa, Fiore, Gianluca, Travascio, Antonio, Uberti, Daniele, Amaddeo, Francesco, Converti, Manlio, Fiorillo, Andrea, Mirandola, Massimo, Pinna, Federica, Ventriglio, Antonio, Galeazzi, Gian Maria, Marchi, Mattia, Arcolin, Elisa, Fiore, Gianluca, Travascio, Antonio, Uberti, Daniele, Amaddeo, Francesco, Converti, Manlio, Fiorillo, Andrea, Mirandola, Massimo, Pinna, Federica, Ventriglio, Antonio, and Galeazzi, Gian Maria

Subjects
LGBTQI, suicidal attempts, mental health, self-harm, suicidal ideation, suicide, Suicide, Attempted, suicidal attempt, Sexual and Gender Minorities, Psychiatry and Mental health, Risk Factors, Humans, Female, Self-Injurious Behavior
Abstract

Research evidence has consistently documented a higher risk of suicidality in the Lesbian, Gay, Bisexual, Transgender, Intersex, and Queer (LGBTIQ) population. This systematic review and meta-analysis aimed to report a detailed description of research data regarding the risk of Attempted Suicide (SA), Suicide Ideation (SI), and Non-Suicidal Self-Injury (NSSI) behaviours for LGBTIQ people and their subgroups. Medline, Scopus, PsycINFO, and EMBASE were searched for studies reporting a comparative estimation of SA, SI, and NSSI rates among LGBTIQ population and the general population (i.e. heterosexual/cisgender), without restrictions on participants’ age and setting for the enrolment. Pooled analyses were based on odds ratios (ORs, with 95% CIs), estimated through inverse variance models with random effects. Fifty studies were selected for the quantitative synthesis and included fifty samples involving 3.735.601 controls and 87.252 LGBTIQ people. LGBTIQ people reported an increased risk of SA (OR:4.36[95%CI:3.32;5.71]), SI (OR:3.76[95%CI:3.02;4.69]), and NSSI (OR:4.24[95%CI:3.23;5.55]). Among LGBTIQ subgroups, the Bisexual group has shown the highest risk of suicidality (SA, OR:6.71; SI, OR:5.04; NSSI, OR: 5.03), followed by the Lesbian-Gay for attempted suicide (SA, OR:6.03), and the Transgender-Intersex-Queer for suicide ideation and non-suicidal self-injury (SI and NSSI, OR:3.42). The quality of the evidence ranged from low to moderate. Our findings have shown that LGBTIQ people report a higher risk of suicidality compared with their cisgender/heterosexual peers. This evidence may contribute to the public awareness on LGBTQI mental health needs and suggest supportive strategies as well as preventive interventions (e.g. supportive programs, counselling, and destigmatizing efforts) as parts of a tailored health-care planning aimed to reduce psychiatric morbidity and mortality in this at-risk population.

Published
2022

198. Mental health in transgender individuals: a systematic review

Author

Pinna, Federica, Paribello, Pasquale, Somaini, Giulia, Corona, Alice, Ventriglio, Antonio, Corrias, Carolina, Frau, Ilaria, Murgia, Roberto, El Kacemi, Sabrina, Galeazzi, Gian Maria, Mirandola, Massimo, Amaddeo, Francesco, Crapanzano, Andrea, Converti, Manlio, Piras, Paola, Suprani, Federico, Manchia, Mirko, Fiorillo, Andrea, Carpiniello, Bernardo, Pinna, Federica, Paribello, Pasquale, Somaini, Giulia, Corona, Alice, Ventriglio, Antonio, Corrias, Carolina, Frau, Ilaria, Murgia, Roberto, El Kacemi, Sabrina, Galeazzi, Gian Maria, Mirandola, Massimo, Amaddeo, Francesco, Crapanzano, Andrea, Converti, Manlio, Piras, Paola, Suprani, Federico, Manchia, Mirko, Fiorillo, Andrea, and Carpiniello, Bernardo

Subjects
gender dysphoria, Gender minorities, mental health, systematic review, transgender individuals, Autism Spectrum Disorder, Gender minoritie, Transgender Persons, Suicidal Ideation, Cross-Sectional Studies, Mental Health, Humans, Randomized Controlled Trials as Topic
Abstract

Several lines of evidence indicate the prevalence of mental health disorders in Transgender (TG) individuals is higher than that of cisgender individuals or the general population. In this systematic review, we aim to propose a summary of some of the most significant research investigating mental health disorders' prevalence among this population. We performed a double-blind systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting (PRISMA) on PUBMED/MEDLINE and SCOPUS, specifically using peer-reviewed articles examining the mental health status of transgender (TG) individuals. This review did not exclude any research based on publication date. The last search was performed in February 2022. The employed search strategy led to the selection of 165 peer-reviewed articles. The majority of these papers presented a cross-sectional design with self-reported diagnoses and symptoms, signaling a significant prevalence of mental health disorders amongst TG Individuals. Of the reviewed articles, 72 examined the prevalence of mood and anxiety disorders; 8 examined eating disorders; 43 examined the prevalence of suicidal or self-harm ideation or behaviors; 5 papers examined the prevalence of trauma and stress-related disorders; 10 examined the frequency of personality disorders; 44 examined substance use disorders; and 9 papers examined the prevalence of autism spectrum disorder. Finally, 22 studies reported on the prevalence of TG individuals diagnosed with co-morbid mental health disorders or unspecified mental disorders. Our findings coincide with existing research, which indicates TG individuals do experience a higher prevalence of mental health disorders than that of the general population or cisgender individuals. However, further research is needed to address the existing gaps in knowledge.

Published
2022

200. Agomelatine: A Potential Multitarget Compound for Neurodevelopmental Disorders.

Author

Savino, Rosa, Polito, Anna Nunzia, Marsala, Gabriella, Ventriglio, Antonio, Di Salvatore, Melanie, De Stefano, Maria Ida, Valenzano, Anna, Marinaccio, Luigi, Bellomo, Antonello, Cibelli, Giuseppe, Monda, Marcellino, Monda, Vincenzo, Messina, Antonietta, Polito, Rita, Carotenuto, Marco, and Messina, Giovanni

Subjects
SEROTONIN antagonists, ATTENTION-deficit hyperactivity disorder, AUTISM spectrum disorders, SEROTONIN agonists, NEUROLOGICAL disorders
Abstract

Agomelatine (AGM) is one of the latest atypical antidepressants, prescribed exclusively for the treatment of depression in adults. AGM belongs to the pharmaceutical class of melatonin agonist and selective serotonin antagonist ("MASS"), as it acts both as a selective agonist of melatonin receptors MT1 and MT2, and as a selective antagonist of 5-HT2C/5-HT2B receptors. AGM is involved in the resynchronization of interrupted circadian rhythms, with beneficial effects on sleep patterns, while antagonism on serotonin receptors increases the availability of norepinephrine and dopamine in the prefrontal cortex, with an antidepressant and nootropic effect. The use of AGM in the pediatric population is limited by the scarcity of data. In addition, few studies and case reports have been published on the use of AGM in patients with attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Considering this evidence, the purpose of this review is to report the potential role of AGM in neurological developmental disorders. AGM would increase the expression of the cytoskeleton-associated protein (ARC) in the prefrontal cortex, with optimization of learning, long-term memory consolidation, and improved survival of neurons. Another important feature of AGM is the ability to modulate glutamatergic neurotransmission in regions associated with mood and cognition. With its synergistic activity a melatoninergic agonist and an antagonist of 5-HT2C, AGM acts as an antidepressant, psychostimulant, and promoter of neuronal plasticity, regulating cognitive symptoms, resynchronizing circadian rhythms in patients with autism, ADHD, anxiety, and depression. Given its good tolerability and good compliance, it could potentially be administered to adolescents and children. [ABSTRACT FROM AUTHOR]

Published
2023
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