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2,950 results on '"Van der Laarse, A"'

161. In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program

Author

Hassan, Ayman K. M., Liem, Su San, van der Kley, Frank, Bergheanu, Sandrin C., Wolterbeek, Ron, Bosch, Jan, Bootsma, Marianne, Zeppenfeld, Katja, van der Laarse, Arnoud, Atsma, Douwe E., Jukema, Wouter J., and Schalij, Martin J.

Published
2009
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163. Landscape Biographies

Author

Kolen, Jan, Renes, Johannes, Hermans, Rita, Bosma, Koos, Renes, Hans, Schmidt, Freek, Kluiving, Sjoerd, van der Laarse, Rob, Kolen, Jan, Renes, Johannes, Hermans, Rita, Bosma, Koos, Renes, Hans, Schmidt, Freek, Kluiving, Sjoerd, and van der Laarse, Rob

Published
2015
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164. Inhibition of monoamine oxidase A in pulmonary artery banding-induced right ventricular failure

Author

Stine Andersen, Asger Andersen, Julie Birkmose Axelsen, Anton Vonk Noordegraaf, Ingrid Schalij, Frances Handoko de Man, Xiao-Qing Sun, Harm Jan Bogaard, Eva L Peters, Willem J. van der Laarse, Pulmonary medicine, Physiology, and ACS - Pulmonary hypertension & thrombosis

Subjects
medicine.medical_specialty, biology, business.industry, Internal medicine, Cardiology, biology.protein, Medicine, Right ventricular failure, Monoamine oxidase A, Cardiology and Cardiovascular Medicine, business, Molecular Biology, Pulmonary artery banding
Published
2020
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169. Author response: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Author

Hessel Honkoop, Dennis EM de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D Nguyen, Cecilia de Heus, Laurence Garric, Mauro J Muraro, Adam Shoffner, Federico Tessadori, Joshua Craiger Peterson, Wendy Noort, Alberto Bertozzi, Gilbert Weidinger, George Posthuma, Dominic Grün, Willem J van der Laarse, Judith Klumperman, Richard T Jaspers, Kenneth D Poss, Alexander van Oudenaarden, Eldad Tzahor, and Jeroen Bakkers

Published
2019
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170. Inhibition of Monoamine Oxidase A in pulmonary artery banding-induced right heart failure

Author

Anton Vonk Noordegraaf, Asger Andersen, Ingrid Schalij, Harm Jan Bogaard, Stine Andersen, Eva L Peters, Xiao-Qing Sun, Willem J. van der Laarse, Julie Birkmose Axelsen, Frances Handoko de Man, Pulmonary medicine, Physiology, ACS - Heart failure & arrhythmias, ACS - Pulmonary hypertension & thrombosis, and APH - Quality of Care

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Pulmonary hypertension, Sevoflurane, Pulmonary artery banding, medicine.anatomical_structure, Monoamine neurotransmitter, Ventricle, medicine.artery, Internal medicine, Pulmonary artery, medicine, Cardiology, Serotonin, business, Saline, medicine.drug
Abstract

Introduction: Oxidation of catecholamines and serotonin by monoamine oxidase–A (MAO-A) may play a role in pulmonary hypertension (PH). MAO-A inhibition (MAOi) decreased proliferation in pulmonary artery intima, and was beneficial in several models of left heart failure. We hypothesized that MAOi will be beneficial in the setting of PH. Methods: Male Wistar rats underwent surgical banding of the pulmonary trunk (PTB) or sham surgery (sham, n=7). Two weeks later, echocardiography was performed and PTB rats were randomized to MAOi (PTB+MAOi, n=12) and treated with clorgyline (2 mg/kg i.p. 3x/week) or saline (PTB, n=12). Rats were treated for five weeks before evaluation echo and pressure-volume-loops (PV loop) were obtained. During echo and PV loops rats where anesthetized with sevoflurane (mix in 1.5L/min O2, 7% for induction, 3.5% for maintainance). Results: MAO-A activity increased almost 3-fold in PTB compared to sham, whereas MAOi completely reversed this. PTB increased total heart- and RV weight, which was partly reversed by MAOi. The ratio of RV weight to left ventricle + septum weight did not change after MAOi. MAOi did not improve RV function or reduce RV dilatation as analyzed by echocardiography or PV loops (Fig. 1). Conclusion: Despite normalization of MAO-A activity in PTB rats, no functional improvements or changes in cardiac size were observed. Histological analyses will further elucidate these findings.

Published
2019
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171. Plasma LDL-Cholesterol Level at Admission is Independently Associated with Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention

Author

Martin J. Schalij, Mathijs C. Bodde, Maaike P. J. Hermans, Arnoud van der Laarse, Ron Wolterbeek, J. Wouter Jukema, and Christa M. Cobbaert

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, Culprit, Myocardial infarct size, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, ST segment, LDL-cholesterol, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Risk factor, Primary percutaneously coronary intervention, Original Research, biology, business.industry, Percutaneous coronary intervention, medicine.disease, ST-segment elevation myocardial infarction, medicine.anatomical_structure, lcsh:RC666-701, biology.protein, Cardiology, Creatine kinase, Cardiology and Cardiovascular Medicine, business, TIMI, Artery
Abstract

Introduction Hypercholesterolemia is a well-known risk factor for developing atherosclerosis and subsequently for the risk of a myocardial infarction (MI). Moreover, it might also be related to the extent of damaged myocardium in the event of a MI. The aim of this study was to evaluate the association of baseline low density lipoprotein-cholesterol (LDL-c) level with infarct size in patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneously coronary intervention (pPCI). Methods Baseline blood samples were obtained from all patients admitted between 2004 and 2014 with STEMI who underwent pPCI. Patients were excluded in case of out of hospital cardiac arrest, treatment delay of at least 10 h or no complete reperfusion after pPCI in the culprit vessel. Peak creatine kinase (CK) level was used for infarct size estimation, defined as the maximal value during admission. Results A total of 2248 patients were included in this study (mean age 61.8 ± 12.2 years; 25.0% female). Mean LDL-c level was 3.6 ± 1.1 mmol/L and median peak CK level was 1275 U/L (IQR 564–2590 U/L). Baseline LDL-c level [β = 0.041; (95% CI 0.019–0.062); p

Published
2019

186. Enhancing Top-Down Analysis Using Chromophore-Assisted Infrared Multiphoton Dissociation from (Phospho)peptides to Protein Assemblies

Author

Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Greisch, Jean-François, van der Laarse, Saar A M, Heck, Albert J R, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Greisch, Jean-François, van der Laarse, Saar A M, and Heck, Albert J R

Published
2020

187. Targeting proline in (phospho)proteomics

Author

Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, van der Laarse, Saar A M, van Gelder, Charlotte A G H, Bern, Marshall, Akeroyd, Michiel, Olsthoorn, Maurien M A, Heck, Albert J R, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, van der Laarse, Saar A M, van Gelder, Charlotte A G H, Bern, Marshall, Akeroyd, Michiel, Olsthoorn, Maurien M A, and Heck, Albert J R

Published
2020

191. Low external pH limits cell death of energy-depleted cardiomyocytes by attenuation of Ca2+ overload

Author

Atsma, Douwe E., Lars Bastiaanse, E.M., Van Der Valk, Lizet, and Van Der Laarse, Arnoud

Subjects
Acidosis -- Analysis, Cell death -- Observations, Heart cells -- Research, Calcium ions -- Usage, Hydrogen-ion concentration -- Analysis, Biological sciences
Abstract

Lactate dehydrogenase release and propidium iodide fluorescence results show that low external pHe prevents the cell death of cultured neonatal rat cardiomyocytes during metabolic inhibition by reducing Ca2+ overload. This reduction of Ca2+ overload is due to inhibition of the sarcolemmal Na+/Ca2+ exchanger upon Na+-free incubation. The lowering of pHe from 7.4 to 6.0 results in no cell death and a temporary conservation of ATP.

Published
1996

199. Abstracts of the XVIII European Conference on Muscle and Motility: De Blije Werelt, Lunteren, The Netherlands September 12–16, 1989

Author

Nesterov, V. P., Peiper, U., Hiller, J., Krienke, B., Schüttler, K., Szymanski, C., Bottinelli, R., Cappelli, V., Minelli, R., Reggiani, C., Schiaffino, S., Carlhoff, D., D'Haese, J., Dabrowska, R., Nowak, E., Borovikov, Y. S., Cummins, P., Russell, G., McLoughlin, D., Cummins, B., Bonet, A., Harricane, M. C., Audemard, E., Mornet, D., Ropert, S., Cavaillé, F., Redwood, C. S., Bryan, J., Cross, R. A., Kendrick-Jones, J., Marston, S. B., Taggart, M., Marston, S., Makuch, R., Stokarska, G., Dabrowska, R., Cecchi, G., Colomo, F., Poggesi, C., Tesi, C., Puceat, M., Clement, O., Lechene, P., Pelosin, J. -M., Ventura-Clapter, R., Vassort, G., Fischer, W., Pfitzer, G., Ankrett, R. J., Rowe, A. J., Bagshaw, C. R., Perry, S. V., Hebisch, S., Levine, B., Moir, A. J. G., Leszyk, J., Derancourt, J., Patcheil, V., Cavadore, C., Collins, J. H., Swiderek, K., Jaquet, K., Mittmann, K., Meyer, H. E., Heilmeyer, Jr, L. M. J., Travers, F., Barman, T., Duvert, M., Grandier-Vazeille, X., Verna, A., Dan-Goor, M., Mühlrad, A., Muhlrad, A., Polzar, B., Kießling, P., Mannherz, H. G., Lehmann-Klose, S., Gröschel-Stewart, U., Bettache, N., Bertrand, R., Kassab, R., Roulet, A., Cardinaud, R., Harford, J. J., Squire, J. M., Maeda, Y., Chew, M. W. K., Huber, Pia, Schaub, Marcus C., Pierobon-Bormioli, S., Betto, R., Ceoldo, S., Salviati, G., Martinez, I., Ofstad, R., Olsen, R. L., Trinick, J., Barlow, D., Gautel, M., Gibson, T., Labeit, S., Leonard, K., Wardale, J., Whiting, A., Draeger, A., Barth, M., Herzog, M., Gimona, M., Small, J. V., Stelzer, E., Amos, B., Ikebe, M., Bernengo, J. C., Rinne, Bettina, Wray, John S., Poole, K. J. V., Goody, R. S., Thomas, Daniel, Rowe, Arthur, Schröder, R. R., Hofmann, W., Müller, U. C., Menetret, J. -F., Wray, J. S., Lakey, A., Tichelaar, W., Ferguson, C., Bullard, B., Kabsch, W., Pai, E. F., Suck, D., Holmes, K. C., Jarosch, Robert, van Mastrigt, R., Pollack, Gerald H., Horowitz, Arie, Anderl, R., Kuhn, H. J., Burton, K., Jung, D. W. G., Blangé, T., Treijtel, B. W., Bagni, M. A., Garzella, P., Huxley, A. F., Beckers-Bleukx, G., Maréchal, G., Bershitsky, S. Y., Tsaturyan, A. K., Woodward, S. K. A., Eccleston, J. F., Geeves, M. A., Knight, Peter, Fortune, Neil, Geeves, Mike, Arner, A., Arheden, H., Lombardi, V., Piazzesi, G., Stienen, G. J. M., Elzinga, G., de Beer, E. L., van Buuren, K. J. H., ten Kate, Y. J., Grundeman, R. L. F., Schiereck, P., Trombitas, K., Versteeg, P. G. A., Rowe, Arthur J., Bolger, Paul, van der Laarse, W. J., Diegenbach, P. C., Flitney, F. W., Jones, D. A., Hatfaludy, S., Shansky, J., Smiley, B., Vandenburgh, H. H., de Haan, A., Lodder, M. A. N., Berquin, A., Lebacq, J., Curtin, N. A., Woledge, R. C., Hellstrand, P., Lönnbro, P., Wadsö, I., Lammertse, T. S., Zaremba, R., Daut, J., Woledge, R. C., Kushmerick, M. J., McFarland, E., Lyons, G. E., Sassoon, D., Ontell, M., and Buckingham, M. E.

Published
1990
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