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153. Additional file 3 of A clinical and cost-effectiveness trial of a parent group intervention to manage challenging restricted and repetitive behaviours in young children with autism spectrum disorder: study protocol for a randomised controlled trial

Author

Grahame, Victoria, Dixon, Linda, Fletcher-Watson, Sue, Garland, Deborah, Glod, Magdalena, Goodwin, Jane, Grayson, Zoe, Heron, Saoirse, Honey, Emma, Iversen, Rebecca, Adetayo S. Kasim, Kernohan, Ashleigh, Kharatikoopaei, Ehsan, Couteur, Ann Le, Mackie, Leila, Mathias, Ayesha, Probert, Helen, Riby, Deborah, Rob, Priyanka, Rogan, Leanne, Thompson, Sarah, Vale, Luke, Walls, Eamonn, Webb, Elspeth Imogen, Weetman, Christopher, Wolstenhulme, Faye, Wood, Ruth, and Rodgers, Jacqui

Subjects
Data_FILES, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Additional file 3. Copy of original funding documentation. NIHR funding documentation.

Published
2021
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154. Additional file 2 of A clinical and cost-effectiveness trial of a parent group intervention to manage challenging restricted and repetitive behaviours in young children with autism spectrum disorder: study protocol for a randomised controlled trial

Author

Grahame, Victoria, Dixon, Linda, Fletcher-Watson, Sue, Garland, Deborah, Glod, Magdalena, Goodwin, Jane, Grayson, Zoe, Heron, Saoirse, Honey, Emma, Iversen, Rebecca, Adetayo S. Kasim, Kernohan, Ashleigh, Kharatikoopaei, Ehsan, Couteur, Ann Le, Mackie, Leila, Mathias, Ayesha, Probert, Helen, Riby, Deborah, Rob, Priyanka, Rogan, Leanne, Thompson, Sarah, Vale, Luke, Walls, Eamonn, Webb, Elspeth Imogen, Weetman, Christopher, Wolstenhulme, Faye, Wood, Ruth, and Rodgers, Jacqui

Abstract

Additional file 2. Ethical approval documentation. HRA ethical approval.

Published
2021
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159. External validation of the OHTS-EGPS model for predicting the 5-year risk of open-angle glaucoma in ocular hypertensives

Author

Takwoingi, Yemisi, Botello, Adriana P, Burr, Jennifer M, Azuara-Blanco, Augusto, Garway-Heath, David F, Lemij, Hans G, Sanders, Roshini, King, Anthony J, Deeks, Jonathan J, Burr, Jennifer, Botello, Adriana, Takwoingi, Yemisi, Hernández, Rodolfo, Vazquez-Montes, Maria, Elders, Andrew, Asaoka, Ryo, Banister, Katie, van der Schoot, Josine, Fraser, Cynthia, King, Anthony, Lemij, Hans, Sanders, Roshini, Vernon, Stephen, Tuulonen, Anja, Kotecha, Aachal, Glasziou, Paul, Garway-Heath, David, Crabb, David, Vale, Luke, Azuara-Blanco, Augusto, Perera, Rafael, Ryan, Mandy, Deeks, Jonathan, and Cook, Jonathan

Published
2014
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162. Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases at presentation after neoadjuvant chemotherapy (ATNEC).

Author

Goyal, Amit, primary, Cramp, Sophie, additional, Wheatley, Duncan, additional, Marshall, Andrea, additional, Puri, Shama, additional, Hammonds, Natalie, additional, Homer, Tara, additional, Vale, Luke, additional, Mir, Romaana, additional, Rose, Janice, additional, Edwards, Helen Teresa, additional, Ahmed, Samreen, additional, Shaaban, Abeer, additional, Elsberger, Beatrix, additional, Bruce, Julie, additional, Gasson, Sophie, additional, Speirs, Valerie, additional, Shaw, Jacqui, additional, Higgins, Helen, additional, and Dunn, Janet, additional

Published
2021
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163. Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)

Author

King, Anthony J, primary, Hudson, Jemma, additional, Fernie, Gordon, additional, Kernohan, Ashleigh, additional, Azuara-Blanco, Augusto, additional, Burr, Jennifer, additional, Homer, Tara, additional, Shabaninejad, Hosein, additional, Sparrow, John M, additional, Garway-Heath, David, additional, Barton, Keith, additional, Norrie, John, additional, McDonald, Alison, additional, Vale, Luke, additional, and MacLennan, Graeme, additional

Published
2021
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164. FENETRE study: quality-assured follow-up of quiescent neovascular age-related macular degeneration by non-medical practitioners: study protocol and statistical analysis plan for a randomised controlled trial

Author

Learoyd, Annastazia E, primary, Tufail, Adnan, additional, Bunce, Catey, additional, Keane, Pearse A, additional, Kernohan, Ashleigh, additional, Robinson, Emily, additional, Jaber, Alijazy, additional, Sadiq, Saqlain, additional, Harper, Robert, additional, Lawrenson, John, additional, Vale, Luke, additional, Waterman, Heather, additional, Douiri, Abdel, additional, and Balaskas, Konstantinos, additional

Published
2021
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165. Economic evaluation of robot-assisted training versus an enhanced upper limb therapy programme or usual care for patients with moderate or severe upper limb functional limitation due to stroke: results from the RATULS randomised controlled trial

Author

Fernandez-Garcia, Cristina, primary, Ternent, Laura, additional, Homer, Tara Marie, additional, Rodgers, Helen, additional, Bosomworth, Helen, additional, Shaw, Lisa, additional, Aird, Lydia, additional, Andole, Sreeman, additional, Cohen, David, additional, Dawson, Jesse, additional, Finch, Tracy, additional, Ford, Gary, additional, Francis, Richard, additional, Hogg, Steven, additional, Hughes, Niall, additional, Krebs, H I, additional, Price, Christopher, additional, Turner, Duncan, additional, Van Wijck, Frederike, additional, Wilkes, Scott, additional, Wilson, Nina, additional, and Vale, Luke, additional

Published
2021
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166. Aneurysm growth, survival, and quality of life in untreated thoracic aortic aneurysms: the effective treatments for thoracic aortic aneurysms study.

Author

Sharples, Linda, Sastry, Priya, Freeman, Carol, Bicknell, Colin, Chiu, Yi Da, Vallabhaneni, Srinivasa Rao, Cook, Andrew, Gray, Joanne, McCarthy, Andrew, McMeekin, Peter, Vale, Luke, and Large, Stephen

Subjects
THORACIC aneurysms, DISEASE progression, THORACIC aorta, QUALITY of life, ANEURYSMS
Abstract

Aims To observe, describe, and evaluate management and timing of intervention for patients with untreated thoracic aortic aneurysms. Methods and results Prospective study of UK National Health Service (NHS) patients aged ≥18 years, with new/existing arch or descending thoracic aortic aneurysms of ≥4 cm diameter, followed up until death, intervention, withdrawal, or July 2019. Outcomes were aneurysm growth, survival, quality of life (using the EQ-5D-5L utility index), and hospital admissions. Between 2014 and 2018, 886 patients were recruited from 30 NHS vascular/cardiothoracic units. Maximum aneurysm diameter was in the descending aorta in 725 (82%) patients, growing at 0.2 cm (0.17–0.24) per year. Aneurysms of ≥4 cm in the arch increased by 0.07 cm (0.02–0.12) per year. Baseline diameter was related to age and comorbidities, and no clinical correlates of growth were found. During follow-up, 129 patients died, 64 from aneurysm-related events. Adjusting for age, sex, and New York Heart Association dyspnoea index, risk of death increased with aneurysm size at baseline [hazard ratio (HR): 1.88 (95% confidence interval: 1.64–2.16) per cm, P < 0.001] and with growth [HR: 2.02 (1.70–2.41) per cm, P < 0.001]. Hospital admissions increased with aneurysm size [relative risk: 1.21 (1.05–1.38) per cm, P = 0.008]. Quality of life decreased annually for each 10-year increase in age [–0.013 (–0.019 to –0.007), P < 0.001] and for current smoking [–0.043 (–0.064 to –0.023), P = 0.004]. Aneurysm size was not associated with change in quality of life. Conclusion International guidelines should consider increasing monitoring intervals to 12 months for small aneurysms and increasing intervention thresholds. Individualized decisions about surveillance/intervention should consider age, sex, size, growth, patient characteristics, and surgical risk. [ABSTRACT FROM AUTHOR]

Published
2022
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168. Minimally invasive versus conventional sternotomy for Mitral valve repair: protocol for a multicentre randomised controlled trial (UK Mini Mitral)

Author

Maier, Rebecca H, primary, Kasim, Adetayo S, additional, Zacharias, Joseph, additional, Vale, Luke, additional, Graham, Richard, additional, Walker, Antony, additional, Laskawski, Grzegorz, additional, Deshpande, Ranjit, additional, Goodwin, Andrew, additional, Kendall, Simon, additional, Murphy, Gavin J, additional, Zamvar, Vipin, additional, Pessotto, Renzo, additional, Lloyd, Clinton, additional, Dalrymple-Hay, Malcolm, additional, Casula, Roberto, additional, Vohra, Hunaid A, additional, Ciulli, Franco, additional, Caputo, Massimo, additional, Stoica, Serban, additional, Baghai, Max, additional, Niranjan, Gunaratnam, additional, Punjabi, Prakash P, additional, Wendler, Olaf, additional, Marsay, Leanne, additional, Fernandez-Garcia, Cristina, additional, Modi, Paul, additional, Kirmani, Bilal H, additional, Pullan, Mark D, additional, Muir, Andrew D, additional, Pousios, Dimitrios, additional, Hancock, Helen C, additional, and Akowuah, Enoch, additional

Published
2021
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169. Prognostic value of test(s) for O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide

Author

McAleenan, Alexandra, additional, Kelly, Claire, additional, Spiga, Francesca, additional, Kernohan, Ashleigh, additional, Cheng, Hung-Yuan, additional, Dawson, Sarah, additional, Schmidt, Lena, additional, Robinson, Tomos, additional, Brandner, Sebastian, additional, Faulkner, Claire L, additional, Wragg, Christopher, additional, Jefferies, Sarah, additional, Howell, Amy, additional, Vale, Luke, additional, Higgins, Julian P T, additional, and Kurian, Kathreena M, additional

Published
2021
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171. Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment on Thrombolysis Delivery During Emergency Stroke Care

Author

Price, Christopher I., Shaw, Lisa, Islam, Saiful, Javanbakht, Mehdi, Watkins, Alan, McMeekin, Peter, Snooks, Helen, Flynn, Darren, Francis, Richard, Lakey, Rachel, Sutcliffe, Lou, McClelland, Graham, Lally, Joanne, Exley, Catherine, Rodgers, Helen, Russell, Ian, Vale, Luke, and Ford, Gary A.

Subjects
B100, A400, B700
Abstract

Importance: Rapid thrombolysis treatment for acute ischemic stroke reduces disability among patients who are carefully selected, but service delivery is challenging.\ud \ud Objective: To determine whether an enhanced Paramedic Acute Stroke Treatment Assessment (PASTA) intervention increased hospital thrombolysis rates.\ud \ud Design, Setting, and Participants: This multicenter, cluster randomized clinical trial took place between December 2015 and July 2018 in 3 ambulance services and 15 hospitals. Clusters were paramedics based within ambulance stations prerandomized to PASTA or standard care. Patients attended by study paramedics were enrolled after admission if a hospital specialist confirmed a stroke and paramedic assessment started within 4 hours of onset. Allocation to PASTA or standard care reflected the attending paramedic's randomization status.\ud \ud Interventions: The PASTA intervention included additional prehospital information collection, a structured hospital handover, practical assistance up to 15 minutes after handover, a predeparture care checklist, and clinician feedback. Standard care reflected national guidelines.\ud \ud Main Outcomes and Measures: Primary outcome was the proportion of patients receiving thrombolysis. Secondary outcomes included time intervals and day 90 health (with poor status defined as a modified Rankin Score >2, to represent dependency or death).\ud \ud Results: A total of 11 478 patients were screened following ambulance transportation; 1391 were eligible and approached, but 177 did not consent. Of 1214 patients enrolled (mean [SD] age, 74.7 [13.2] years; 590 women [48.6%]), 500 were assessed by 242 paramedics trained in the PASTA intervention and 714 were assessed by 355 paramedics continuing with standard care. The paramedics trained in the PASTA intervention took a mean of 13.4 (95% CI, 9.4-17.4) minutes longer (P

Published
2020

172. EULT_manuals_070220 – Supplemental material for Evaluation of the enhanced upper limb therapy programme within the Robot-Assisted Training for the Upper Limb after Stroke trial: descriptive analysis of intervention fidelity, goal selection and goal achievement

Author

Bosomworth, Helen, Rodgers, Helen, Shaw, Lisa, Smith, Leanne, Aird, Lydia, Howel, Denise, Wilson, Nina, Alvarado, Natasha, Sreeman Andole, Cohen, David L, Dawson, Jesse, Fernandez-Garcia, Cristina, Finch, Tracy, Ford, Gary A, Francis, Richard, Hogg, Steven, Hughes, Niall, Price, Christopher I, Ternent, Laura, Turner, Duncan L, Vale, Luke, Wilkes, Scott, Hermano I Krebs, and Wijck, Frederike Van

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, EULT_manuals_070220 for Evaluation of the enhanced upper limb therapy programme within the Robot-Assisted Training for the Upper Limb after Stroke trial: descriptive analysis of intervention fidelity, goal selection and goal achievement by Helen Bosomworth, Helen Rodgers, Lisa Shaw, Leanne Smith, Lydia Aird, Denise Howel, Nina Wilson, Natasha Alvarado, Sreeman Andole, David L Cohen, Jesse Dawson, Cristina Fernandez-Garcia, Tracy Finch, Gary A Ford, Richard Francis, Steven Hogg, Niall Hughes, Christopher I Price, Laura Ternent, Duncan L Turner, Luke Vale, Scott Wilkes, Hermano I Krebs and Frederike van Wijck in Clinical Rehabilitation

Published
2020
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173. Additional file 3 of Cost-effectiveness of child caries management: a randomised controlled trial (FiCTION trial)

Author

Homer, Tara, Maguire, Anne, Douglas, Gail, Innes, Nicola, Clarkson, Jan, Wilson, Nina, Ryan, Vicky, McColl, Elaine, Robertson, Mark, and Vale, Luke

Abstract

Additional file 3 “Cost-effectiveness analysis for the comparison of PA vs B+P vs C+P arms based on fee-for-service costs in Scotland only (n=287)” is a the results of a sensitivity analysis which estimates costs based on charges to the NHS, based on the Scottish reimbursement rates (fee-for-service).

Published
2020
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174. Additional file 5 of Cost-effectiveness of child caries management: a randomised controlled trial (FiCTION trial)

Author

Homer, Tara, Maguire, Anne, Douglas, Gail, Innes, Nicola, Clarkson, Jan, Wilson, Nina, Ryan, Vicky, McColl, Elaine, Robertson, Mark, and Vale, Luke

Subjects
health care economics and organizations
Abstract

Additional file 5. “Cost-effectiveness analysis for the comparison of PA vs B+P vs C+P based on units of dental activity (England and Wales) and fee-for service (Scotland) costs (n=1058)” is a the results of a sensitivity analysis which estimates costs based on charges to the NHS, based on the both the Scottish and English reimbursement rates.

Published
2020
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176. Additional file 4 of Cost-effectiveness of child caries management: a randomised controlled trial (FiCTION trial)

Author

Homer, Tara, Maguire, Anne, Douglas, Gail, Innes, Nicola, Clarkson, Jan, Wilson, Nina, Ryan, Vicky, McColl, Elaine, Robertson, Mark, and Vale, Luke

Subjects
stomatognathic diseases, health care economics and organizations
Abstract

Additional file 4. “Cost-effectiveness analysis for the comparison of PA vs B+P vs C+P arms based on units of dental activity in England and Wales only costs (n=771)” is a the results of a sensitivity analysis which estimates costs based on charges to the NHS, based on the English reimbursement rates (Units of Dental Activity).

Published
2020
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178. Additional file 1 of Surgical treatments for women with stress urinary incontinence: a systematic review of economic evidence

Author

Javanbakht, Mehdi, Moloney, Eoin, Brazzelli, Miriam, Wallace, Sheila, Omar, Muhammad Imran, Ash Monga, Saraswat, Lucky, Mackie, Phil, Imamura, Mari, Hudson, Jemma, Shimonovich, Michal, MacLennan, Graeme, Vale, Luke, and Craig, Dawn

Abstract

Additional file 1 Table S1. Search strategy. Table S2. The total number of studies retrieved by the individual databases is provided in table below. Fig. S1. Incremental net monetary benefit for surgical interventions (WTP=US$30K)—Results are NOT based on a meta-analysis. Fig. S2. Incremental net monetary benefit for surgical interventions (WTP=US$40K)—Results are NOT based on a meta-analysis

Published
2020
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181. The Value of Myocardial Perfusion Scintigraphy in the Diagnosis and Management of Angina and Myocardial Infarction: A Probabilistic Economic Analysis

Author

Hernandez, Rodolfo and Vale, Luke

Subjects
Heart attack -- Diagnosis, Radioisotope scanning -- Methods -- Usage, Angina pectoris -- Diagnosis, Health, Diagnosis, Usage, Methods
Abstract

Byline: Rodolfo Hernandez, MSc (Health Economics Research Unit, University of Aberdeen, Aberdeen, Scotland, UK, r.a.hernandez @abdn.ac.uk); Luke Vale, PhD (Health Economics Research Unit, University of Aberdeen, Aberdeen, Scotland, UK, Health [...]

Published
2007
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182. Early treatment with prednisolone or acyclovir in Bell's palsy

Author

Sullivan, Frank M., Swan, Jain R. C., Donnan, Peter T., Morrison, Jillian M., Stewart, Ken, Smith, Blair H., McKinstry, Brian, Daly, Fergus, Davenport, Richard J., Vale, Luke D., Clarkson, Janet E., Hammersley, Victoria, Hayavi, Sima, and McAteer, Anne

Subjects
Corticosteroids -- Research, Paralysis, Facial -- Care and treatment, Paralysis, Facial -- Research, Prednisolone -- Research
Abstract

The effectiveness of an early treatment of the Bell's palsy disease by various corticosteroids and antiviral agents, like prednisolone or acyclovir is discussed. The results show that an early treatment with prednisolone highly improves the chance of complete recovery of the patient in a short span of time.

Published
2007

183. Abstract OT-04-01: Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases at presentation after neoadjuvant chemotherapy - ATNEC (ClinicalTrials.gov NCT04109079)

Author

Goyal, Amit, primary, Cramp, Sophie, additional, Wheatley, Duncan, additional, Marshall, Andrea, additional, Puri, Shama, additional, Homer, Tara, additional, Vale, Luke, additional, Mir, Romaana, additional, Nabi, Zohal, additional, Rose, Janice, additional, Edwards, Helen Teresa, additional, Ahmed, Samreen, additional, Shaaban, Abeer, additional, Elsberger, Beatrix, additional, Bruce, Julie, additional, Gasson, Sophie, additional, Speirs, Valerie, additional, Shaw, Jacqui, additional, Higgins, Helen, additional, and Dunn, Janet, additional

Published
2021
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184. A Clinical and Cost Effectiveness Trial of A Parent Group Intervention To Manage Challenging Restricted and Repetitive Behaviours In Young Children With Autism Spectrum Disorder: Study Protocol For a Randomized Controlled Trial.&nbsp;

Author

Grahame, Victoria, primary, Dixon, Linda, additional, Fletcher-Watson, Sue, additional, Garland, Deborah, additional, Glod, Magdalena, additional, Goodwin, Jane, additional, Grayson, Zoe, additional, Heron, Saoirse, additional, Honey, Emma, additional, Iversen, Rebecca, additional, Kasim, Adetayo S, additional, Kernohan, Ashleigh, additional, Kharatikoopaei, Eshan, additional, Couteur, Ann Le, additional, Mackie, Leila, additional, Mathias, Ayesha, additional, Probert, Helen, additional, Riby, Deborah, additional, Rob, Priyanka, additional, Rodgers, Jacqui, additional, Rogan, Leanne, additional, Thompson, Sarah, additional, Vale, Luke, additional, Walls, Eamonn, additional, Webb, Elspeth Imogen, additional, Weetman, Christopher, additional, Wolstenhulme, Faye, additional, and Wood, Ruth, additional

Published
2021
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186. Alternative to Prophylactic Antibiotics for the Treatment of Recurrent Urinary Tract Infections in Women (ALTAR): A Multi-Centre Randomised, Non-Inferiority Trial

Author

Harding, Christopher Karl, primary, Mossop, Helen, additional, Homer, Tara, additional, Chadwick, Thomas, additional, King, William, additional, Carnell, Sonya, additional, Lecouturier, Jan, additional, Abouhajar, Alaa, additional, Vale, Luke, additional, Watson, Gillian, additional, Forbes, Rebecca, additional, Currer, Stephanie, additional, Pickard, Robert, additional, Eardley, Ian, additional, Pearce, Ian, additional, Thiruchelvam, Nikesh, additional, Guerrero, Karen, additional, Walton, Katherine, additional, Hussain, Zahid, additional, Lazarowicz, Henry, additional, and Ali, Ased, additional

Published
2021
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189. Corrigendum: Brief alcohol intervention for risky drinking in young people aged 14–15 years in secondary schools: the SIPS JR-HIGH RCT

Author

Giles, Emma L, primary, McGeechan, Grant J, additional, Coulton, Simon, additional, Deluca, Paolo, additional, Drummond, Colin, additional, Howel, Denise, additional, Kaner, Eileen, additional, McColl, Elaine, additional, McGovern, Ruth, additional, Scott, Stephanie, additional, Stamp, Elaine, additional, Sumnall, Harry, additional, Todd, Liz, additional, Vale, Luke, additional, Albani, Viviana, additional, Boniface, Sadie, additional, Ferguson, Jennifer, additional, Gilvarry, Eilish, additional, Hendrie, Nadine, additional, Howe, Nicola, additional, Mossop, Helen, additional, Ramsay, Amy, additional, Stanley, Grant, additional, and Newbury-Birch, Dorothy, additional

Published
2020
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193. Cost-effectiveness of an enhanced Paramedic Acute Stroke Treatment Assessment (PASTA) during emergency stroke care: Economic results from a pragmatic cluster randomized trial.

Author

Bhattarai, Nawaraj, Price, Christopher I, McMeekin, Peter, Javanbakht, Mehdi, Vale, Luke, Ford, Gary A, and Shaw, Lisa

Subjects
CLUSTER randomized controlled trials, THROMBOLYTIC therapy, STROKE units, QUALITY-adjusted life years, COST effectiveness, HOSPITAL costs, EMERGENCY medical technicians, PASTA
Abstract

Background: The Paramedic Acute Stroke Treatment Assessment (PASTA) trial evaluated an enhanced emergency care pathway which aimed to facilitate thrombolysis in hospital. A pre-planned health economic evaluation was included. The main results showed no statistical evidence of a difference in either thrombolysis volume (primary outcome) or 90-day dependency. However, counter-intuitive findings were observed with the intervention group showing fewer thrombolysis treatments but less dependency. Aims: Cost-effectiveness of the PASTA intervention was examined relative to standard care. Methods: A within trial cost-utility analysis estimated mean costs and quality-adjusted life years over 90 days' time horizon. Costs were derived from resource utilization data for individual trial participants. Quality-adjusted life years were calculated by mapping modified Rankin scale scores to EQ-5D-3L utility tariffs. A post-hoc subgroup analysis examined cost-effectiveness when trial hospitals were divided into compliant and non-compliant with recommendations for a stroke specialist thrombolysis rota. Results: The trial enrolled 1214 patients: 500 PASTA and 714 standard care. There was no evidence of a quality-adjusted life year difference between groups [0·007 (95% CI: −0·003 to 0·018)] but costs were lower in the PASTA group [−£1473 (95% CI: −£2736 to −£219)]. There was over 97.5% chance that the PASTA pathway would be considered cost-effective. There was no evidence of a difference in costs at seven thrombolysis rota compliant hospitals but costs at eight non-complaint hospitals costs were lower in PASTA with more dominant cost-effectiveness. Conclusions: Analyses indicate that the PASTA pathway may be considered cost-effective, particularly if deployed in areas where stroke specialist availability is limited. Trial Registration: ISRCTN12418919 www.isrctn.com/ISRCTN12418919 [ABSTRACT FROM AUTHOR]

Published
2022
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194. Effectiveness and Cost-Effectiveness of Screening and Brief Alcohol Intervention to Reduce Alcohol Consumption in Young People in the High School Setting: A Pragmatic Randomized Controlled Trial (SIPS JR-HIGH).

Author

Coulton, Simon, Giles, Emma L, McGeechan, Grant J, Deluca, Paolo, Drummond, Colin, Howel, Denise, Kaner, Eileen, McColl, Elaine, McGovern, Ruth, Scott, Stephanie, Sumnall, Harry, Vale, Luke, Albani, Viviana, Boniface, Sadie, Ferguson, Jennifer, Gilvarry, Eilish, Hendrie, Nadine, Howe, Nicola, Ramsay, Amy, and Newbury-Birch, Dorothy

Subjects
PILOT projects, CLUSTER sampling, RESEARCH, CONFIDENCE intervals, ALCOHOL-induced disorders, MULTIPLE regression analysis, MEDICAL screening, TREATMENT effectiveness, RANDOMIZED controlled trials, COMPARATIVE studies, ALCOHOL drinking, COST effectiveness, RESEARCH funding, DATA analysis software, LOGISTIC regression analysis, HIGH school students, LONGITUDINAL method, SECONDARY analysis
Abstract

The article presents the discussion on Chief Medical Officer for England recommending that young people remaining alcohol free until 18 years of age. Topics include highest levels of drinking among adolescents and the North East England being one of the highest levels of adolescent alcohol consumption in the UK; and exploring the relationship between alcohol use during adolescence and negative consequences in adulthood.

Published
2022
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195. Quality of systematic reviews of economic evaluations in health care. (Quality Issues and Standards)

Author

Jefferson, Tom, Demicheli, Vittorio, and Vale, Luke

Subjects
Cost benefit analysis -- Research, Medical care, Cost of -- Research, Medical economics -- Research
Abstract

The quality of research articles that evaluate the cost-effectiveness of specific medical treatments is improving, but authors could still do more to make these articles useful. Doctors and hospital administrators rely on these types of articles to provide the best medical care at the lowest cost., Context: Reviews performed almost a decade ago showed considerable gaps in the quality of reporting and methods applied to economic evaluations of health care interventions. Measures taken by the research community to address the issue included the promulgation of guidelines and the publicizing of good practice in economic evaluation. Methods: To assess the quality of methods of systematic reviews, economic evaluations in health care, and reporting methods, we conducted full-text searches of private and public databases for the period 1990 through March 2001 and corresponded with researchers active in the field. A total of 102 reports were identified, but only 39 were included. Quality of systematic reviews was assessed by a 6-item checklist. Results: Quality of review methods was reasonable, but more attention needs to be paid to search methods and standardization of evaluation instruments. The reviews found consistent evidence of serious methodological flaws in a significant number of economic evaluations. Lack of clear descriptions of methods, lack of explanation and justification for the framework and approach used, and low-quality estimates of effectiveness for the interventions evaluated were the most frequent flaws. Modest improvements in quality of conducting and reporting economic evaluations appear to have taken place in the last decade. Conclusions: Proper allocation of resources on the basis of economic evaluations remains uncertain. Editorial teams and regulatory bodies should perform quality assurance based on a single widely accepted and validated standard instrument.

Published
2002

199. Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT

Author

Pickard, Robert, primary, Goulao, Beatriz, additional, Carnell, Sonya, additional, Shen, Jing, additional, MacLennan, Graeme, additional, Norrie, John, additional, Breckons, Matt, additional, Vale, Luke, additional, Whybrow, Paul, additional, Rapley, Tim, additional, Forbes, Rebecca, additional, Currer, Stephanie, additional, Forrest, Mark, additional, Wilkinson, Jennifer, additional, McColl, Elaine, additional, Andrich, Daniela, additional, Barclay, Stewart, additional, Cook, Jonathan, additional, Mundy, Anthony, additional, N’Dow, James, additional, Payne, Stephen, additional, and Watkin, Nick, additional

Published
2020
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200. Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)

Author

Goulao, Beatriz, primary, Carnell, Sonya, additional, Shen, Jing, additional, MacLennan, Graeme, additional, Norrie, John, additional, Cook, Jonathan, additional, McColl, Elaine, additional, Breckons, Matt, additional, Vale, Luke, additional, Whybrow, Paul, additional, Rapley, Tim, additional, Forbes, Rebecca, additional, Currer, Stephanie, additional, Forrest, Mark, additional, Wilkinson, Jennifer, additional, Andrich, Daniela, additional, Barclay, Stewart, additional, Mundy, Anthony, additional, N’Dow, James, additional, Payne, Stephen, additional, Watkin, Nick, additional, and Pickard, Robert, additional

Published
2020
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