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This study assessed the clinical efficacy of screening for noise induced hearing loss (NIHL) with distortion product otoacoustic emissions (DPOAE). DPOAEs were recorded from 76 military personnel (137 ears) aged between 17 and 41 years in response to equilevel 70 dB SPL primary stimulating tones. The 2f1-f2 DPOAE levels were correlated with audiometric thresholds at frequencies close to f2. Ears with normal audiograms, but with a history of military noise exposure, had DPOAEs that were significantly decreased in amplitude as compared to the ears of normal hearing non-exposed to noise subjects. These ears also had an increased absence of DPOAEs as compared with the ears of the normal hearing non-exposed to noise subjects. Although, in general, the DPOAE amplitudes and spectral frequency ranges reflected the audiometric NIHL configurations, in a number of cases DPOAEs were present for hearing losses up to 75 dB HL. As a consequence, DPOAEs correlated moderately and negatively with the audiometric thresholds. Applying test criteria designed to logically reflect NIHL, DPOAE sensitivity and specificity levels ranged between 0.51-0.90 and 0.63-0.25, respectively. These findings indicate that DPOAEs, recorded and analysed as described, are not sufficiently sensitive to serve as a single test to identify NIHL.

We estimated potential of optic aggregometry for the identification of patients with coronary heart disease in 271 patients with coronary heart disease (CHD) and 230 ones with FC 2-3 angina of effort. Duration of the study was 24 months. Platelet aggregation in patients given anti-aggregation therapy with acetylsalicylic acid (ASA) was assessed with a Biola laser aggregometer (Russia) from changes in transmissivity in the presence of aggregation agonists. Optic aggregometry permitted to distinguish the forms of CHD producing increased risk of atherothrombotic complications in patients with enhanced platelet functional activity resistant to ASA. The prevalence of ACA resistance was estimated at 10% and did not depend on the form of CHD. It was 11.3 and 9.95% in patients with stable angina and acute coronary syndrome respectively. Resistance to ACA was an independent predictor of atherothrombotic complications in patients with different forms of CHD (OR = 8.25; 95% CI 5.77-11.82; p = 0.05).

Aim of the study was to elucidate gender related characteristics of clinical status and treatment of patients with atrial fibrillation (AF) hospitalized in a department of urgent cardiology of multiprofile clinical hospital. In a retrospective pharmacoepidemiological study we analyzed case histories of 114 men and 79 women hospitalized because of detected and electrocardiografically confirmed paroxysmal or persistent AF. Compared to men women were significantly older, among them there were significantly more individuals older than 75 years (lt;0.05), and AF developed in women at older age (lt;0.05). However duration of arrhythmic anamnesis was similar in women and men. Among women we noted greater prevalence of ischemic heart disease; they had higher risk of thromboembolic complications and higher rate of these complications in anamnesis. Rates of obesity and diabetes mellitus were also higher among women. Men more often had isolated arterial hypertension and lung diseases. There were more smokers among men. Women significantly less often received adequate antithrombotic therapy; they were less often subjected to electrical cardioversion. Rate control strategy was more often selected for women.

We present data on possibility of anticoagulant therapy in conjunction with electrical cardioversion in patients with atrial fibrillation using novel anticoagulant - dabigatran - and a case of successful lysis of thrombus in the left ventricular cavity at the background of its administration.

Data on effect of early reperfusion on prognosis of patients with myocardial infarction, possibilities of development of "aborted myocardial infarction", data on prognosis of "aborted myocardial infarction" and its prevalence are presented.

Aim of the study was to assess efficacy of the use of telemetric support of prehospital thrombolytic therapy (TLT) of myocardial infarction. We observed 206 patients with ST-elevation myocardial infarction (MI). These patients were divided into 2 groups: in one TLT was initiated after admission to hospital, in the other TLT was carried out by ambulance personnel with telemetric support. We analyzed times from onset of symptoms, rates of development of complications of MI and TLT. The use of telemetric support of ambulance personnel allowed to substantially shorten time from onset of symptoms to initiation of TLT, to minimize errors during its course and allowed to coordinate actions of physicians of ambulances and specialized hospital departments with comparable number of adverse events.

To illustrate feasibility of successful correction of chronic long-standing right-side inferioatrial tachycardia (RIT).A case report of examination and effective treatment of long-standing RIT. The diagnosis was made after ECG, Holter ECG monitoring, Doppler echocardiography, endocardial electrophysiological examination, analysis of the disease history.Conservative treatment proved low effective. Imaging diagnostic methods and x-ray surgery (radiofrequency ablation of the ectopic activity zone) were leading techniques.If a patient is operated (radiofrequency ablation) early, he will not have to take long-term treatment with antiarrhythmic drugs and will be able to live without limitations deteriorating his quality of life.

The study was designed to elucidate the relationship between severity of coronary atherosclerosis in patients with stable angina and the degree of spatial inhomogeneity of repolarization processes. A total of 104 patients aged 51.1 +/- 8.1 years with FC II-IV angina were examined using a treadmill test, selective coronarography, and Doppler echocardiography. Spatial inhomogeneity of repolarization processes was estimated from the difference between maximum and minimum QT and QTa intervals (dispersion), recorded synchronously in 12 leads at rest and at a maximum load. Factor analysis of spatial dQT at the maximum treadmill exercise showed that patients with CHD had hemodynamically significant coronary atherosclerosis associated with elevated level of myocardial repolarization inhomogeneity affected by such factors as arterial hypertension, left ventricular hypertrophy, age and functional state of the patients.

Changes of QT and QTa interval dispersion during stress test on treadmill and possible dependence of these changes on results of stress test and severity of coronary atherosclerosis were studied in 82 patients with effort angina. All patients were subjected to stress test on treadmill and selective coronary angiography. Before and immediately after stress test duration and dispersion of intervals QT, QTa, QTc and QTac were measured. Basing on obtained results a conclusion was made that changes of QT interval in patients with ischemic heart disease after stress test could be caused by changes of terminal part of T-wave.

Analysis of data collected during observation upon 76 patients with odontogenic phlegmon of maxillofacial region of different severity in complex treatment plan of whom preparation Perftorane was included according to the worked out method. Based upon received clinical, morphological, cytological and biochemical results the conclusion was derived that the application of the worked out method of perftorane use optimized traditional method of treatment of patients with odontogenic phlegmon of maxillofacial region exerting antihypoxic, desintoxicatic and antioxidant actions that led finally to speedy clearing of suppurative focus and to stimulation reparative processes in the wound.

Учитывая антропосоциальные особенности приверженности к той или иной модели употребления алкоголя и противоречивые сведения о влиянии алкоголя на здоровье населения, была поставлена цель — оценить влияние модели потребления алкоголя на общий сердечно-сосудистый риск на примере городских жителей трудоспособного возраста. Материал и методы. Проведено сплошное поперечное исследование работников двух предприятий городской агломерации (Саратов и Энгельс). Результаты. Установлено влияние модели потребления алкоголя на общий сердечно-сосудистый риск у лиц трудоспособного возраста: относительно благоприятный эффект моделей потребления низкоалкогольных напитков (пиво, сухие и игристые вина) в плане 10-летнего риска наступления фатального сердечно-сосудистого события по сравнению с моделью предпочтения крепких алкогольных напитков. Среди городского населения трудоспособного возраста предпочитаемый тип алкогольного напитка ассоциирован как с модифицируемыми, так и немодифицируемыми факторами сердечно-сосудистого риска. Выявлена преимущественная реализация снижения кардиоваскулярного риска в случае предпочтения пива как алкогольного напитка за счет поведенческих и возрастных, а в случае предпочтения сухих и игристых вин — за счет метаболических факторов. Заключение. Проведенное исследование свидетельствует о целесообразности учета модели употребления алкоголя при индивидуальной стратификации кардиоваскулярного риска и профилактике сердечно-сосудистых заболеваний, включающей в том числе формирование культуры потребления алкогольных напитков. Ключевые слова: модель употребления алкоголя, сердечно-сосудистый риск, трудоспособный возраст. Objective — to evaluate the impact of an alcohol drinking pattern on total cardiovascular risk in able-bodied urban dwellers, by taking into account the anthropological and social characteristics of their compliance with one or another drinking pattern and controversial information on the effect of alcohol on the population’s health. Material and methods. A continuous cross-sectional survey was conducted in employees from two enterprises in the urban agglomerations Saratov and Engels. Results. The alcohol drinking pattern has been ascertained to have an impact on total cardiovascular risk in able-bodied people: unlikely the drinking pattern of low-alcohol drinks (beer, dry and effervescent wines) as compared to that of strong alcoholic beverages has a relatively beneficial effect on 10-year risk of fatal cardiovascular disease. The preferred alcoholic beverage in the able-bodied urban population is associated with both modified and unmodified cardiovascular risk factors. The cardiovascular risk has been found to be predominantly lower when beer is preferred as an alcoholic drink due to behavioral and age-related factors and when dry and effervescent wines are preferred due to metabolic factors. Conclusion. The survey suggests that it is expedient to take into consideration the alcohol drinking pattern in cardiovascular risk stratification in individuals and cardiovascular disease prevention, including the formation of alcohol drinking culture.

The subjects of the study were 135 patients with acute Q-wave and non-Q-wave myocardial infarction (MI) aged 36 to 78 years (mean 62.4 +/- 11.2 years). 59 patients (main group) developed early postinfarction angina (EPA). 76 patients (control group) had no stenocardia attacks within the entire period of hospital treatment. In the patients with EPA corrected QT interval dispersion was greater within the entire period of hospital treatment: 81.2 +/- 7.6 and 67.1 +/- 4.6 ms1/2 on the first day, 74.6 +/- 6.0 and 70.3 +/- 4.7 ms1/2 on the third day, 82.1 +/- 6.5 and 71.6 +/- 6.2 ms1/2 on the seventh day, 88.7 +/- 6.2 and 69.4 +/- 8.2 ms1/2 on the 28th day, respectively. Heart rate entropy decreased in both groups, but before discharge (mean 28th day) the patients with EPA demonstrated its significant reduction compared to the patients without EPA (3.89 +/- 0.16 and 4.13 +/- 0.09 bits, respectively, p0.05). Thus, recurrent myocardial ischemia in patients with MI, manifesting by EPA attacks, leads to the increase of QT interval dispersion and to heart rate rigidity which apparently mirrors greater probability of myocardial electric instability and increased risk of fatal arrhythmias in such patients.

Morphological parameters (tissue necrosis area, area of connective tissue sites, neutrophil/round cells ratio, activities of the nucleolar organizer areas) are suggested as criteria for evaluating the treatment efficiency in patients with maxillofacial pyoinflammatory diseases.

To comparatively study Q-T interval duration in groups of patients with coronary heart disease (CHD) identified by the cause of exercise test cessation.Bicycle ergometric test (BET) was performed in 93 males with CHD (functional class II-III angina pectoris on exertion). During BET, ECG recorded in the leads, as described by Nebu. The QT interval was visually measured in one lead. This interval was determined as a distance between the onset of a Q wave and the end of a T wave (in mlsec). The mean value by 3 cardiac cycles was taken as an actual value of the QT interval. To compare the duration of the QT interval at different rates of cardiac rhythm, its corrected value (QTc) was calculated.In case of positive BET (anginal attack, 1-mm or more depressed ST segment at a distance of 0.8 cm from the joint J), the values of QT and QTc measured at rest and peak exercise were greater than those if the cause of test cessation was the submaximum heart rate or a patient's fatigue. The value of QTc was higher if the cause of BRT cessation was 1-mm or more depressed ST segment preceding an anginal attack or the only cause of test cessation.

The production conditions and structure for composite materials based on glass ceramic reinforced with electrically conducting fibers have been examined. A unit is described for applying coatings on continuously moving fiber using electrophoresis. It is shown that it is practical to vary the volume relationship between the matrix and the fiber over wide ranges.

Vitamin D (VD) deficiency connecting with insufficient production in the skin and limited alimentation delivery, disrupts the function of all system of the body and increases the risk of women health. VD receptor and VD metabolizing enzymes have been detected in female reproductive tissues, such as ovary, uterus and placenta. There is an increasing human data suggesting that VD status may be associated with impaired fertility, endometriosis, polycystic ovary syndrome, and ovarian cancer. We studied the role of Vitamin D deficiency andpathogenesis role in the development of deficiency of Luteal Phase.Was detected the positive correlations with premenstrual bleeding, luteal progesterone and estradiol levels and no connecting with post peak duration.

The microstructure and hardness of electrophoretic chromium carbide coatings on certain structural and tool steel grades have been examined under the initial surface roughness. X-ray spectral studies on the coating and a transition zone have been carried out. It can be shown that the roughness and hardness of chromium carbide coatings are only slightly dependent on the initial steel substrate roughness. It has also been shown that the coating hardness is essentially dependent on the steel chemical composition, and is governed by the solubility and diffusion interchange differences between the coating and the substrate during liquid phase sintering of the coating.

This study demonstrates a clear relationship between noise induced tinnitus (NIT) and efferent neural auditory activity. The effect of contralateral white noise stimulation on click evoked otoacoustic emissions (CEOAEs) was studied in chronic tinnitus sufferers and controls, with and without a noise induced hearing loss (NIHL). For the non-tinnitus controls, increased contralateral white noise intensities resulted in decreased CEOAE amplitudes, irrespective of the hearing configuration. In contrast, the tinnitus patients responded with increased CEOAE amplitudes, particularly at lower contralateral noise intensities. While this was observed for both normal hearing and NIHL tinnitus patients, the effect was more pronounced amongst the normal hearing group. These findings were interpreted as reflecting a global efferent disorder in NIT patients, and are considered clinically relevant to the objective assessment of tinnitus.

It was previously demonstrated that noise induced tinnitus (NIT) patients have prolonged reaction times and event related potentials (ERPs) that are reduced in amplitude and prolonged in latency. This study considered whether these alterations occurred as a consequence of the competing auditory tinnitus sensation or as a result of a possible cognitive processing dysfunction in NIT patients. ERPs and reaction times (RTs) were recorded in response to a standard oddball auditory target detection paradigm, with and without simulated tinnitus. Tinnitus was simulated using a high tone narrow band noise presented at the forehead via a standard audiometric bone vibrator. The subjects consisted of 19 males suffering from noise induced hearing loss without tinnitus. The latencies and amplitudes of the ERP components N1, P2, N2, and P3, as recorded along the midline scalp sites (Fz, Cz, and Pz) and bilateral temporal sites (C3 and C4), did not differ significantly when recorded with and without simulated tinnitus. Similarly, the associated reaction times did not differ significantly. These findings suggest that the ERP alterations previously reported to exist for NIT patients cannot be explained simply as a consequence of increased task difficulty and cognitive loading due to the tinnitus sound.

The sinter-bonding of electrophoretically deposited Cr3C2 coatings to KKhN and KKhNF chromium carbide alloys is a result of liquid-phase reaction and of migration of the metallic phase from the basis materials to the carbide layers. The structure and properties of resultant coatings are determined by the sinter-bonding temperature and the composition of the basis material, but are not significantly affected by the latter's condition. Phosphorus-free chromium carbide alloys are preferable to KKhNF alloys as basis materials because they enable optimum properties in coatings to be obtained at a lower temperature.

In sintering chromium carbide coatings deposited by electrophoresis on a steel base alloying of the binder and the transition zone with chromium occurs. The iron diffuses into the transition zone and the binder and alloys the carbide.

1. The intensification of the process of sintering of an electrophoretic deposit applied to a steel basis with a nickel-phosphorus undercoat is due to rapid penetration of a liquid phase forming in the latter at 890°C. 2. The reaction of the liquid phase with particles of the nickel-phosphorus binder averages out their phosphorus contents, causing the liquid to disappear. 3. One cause of defects in sintered electrophoretic chromium carbide coatings is the presence in them of cracks before sintering.

Relationships between temperatures at various points of a heat liberating element are established.

Aim. То investigate the link between dynamics of QT and QTa duration and dispersion, corrected QT and QTa (QTc, QTac) in coronary heart disease (CHD) patients undergoing treadmill stress test, with ventricular arrhythmia registration. Material and metliods. In total, 77 patients with Functional Class II-FV angina were examined (mean age 51,1+8,1 years). All patients underwent treadmill stress test and coronary angiography. According to stress test results, two groups were identified: Group I (n=63) - without cardiac arrhythmias, and Group II (n=14) - with ventricular ectopic activity. Before and after stress test, QT, QTa, QTc, and QTac duration and dispersion were calculated. Results. During stress test, dQT and dQTc increased in both groups. In patients with ventricular arrhythmias, mean dQTa and dQTac decreased after stress test. In both groups, there was no significant difference in mean QT, QTc, QTa, or QTac duration before and after stress test. Conclusion. In CHD patients, ischemia-mediated dQT changes could be linked to terminal T wave variability. Reduced dQTa, as well as increased dQT, in stress test might reflect increased risk of ventricular arrhythmias in CHD patients.

An experimental study has been made concerning the regular heating mode of bodies during radiative interaction. A method of calculating the temperature fields in interacting bodies has been developed in the basis of relations derived here for the regular heating mode.