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935 results on '"Umeda, N."'

152. Design of a −1 MV dc UHV power supply for ITER NBI

Author

Watanabe, K., primary, Yamamoto, M., additional, Takemoto, J., additional, Yamashita, Y., additional, Dairaku, M., additional, Kashiwagi, M., additional, Taniguchi, M., additional, Tobari, H., additional, Umeda, N., additional, Sakamoto, K., additional, and Inoue, T., additional

Published
2009
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154. Development of 1 MeV H[sup −] Accelerator at JAEA for ITER NB

Author

Taniguchi, M., primary, de Esch, H. P. L., additional, Svensson, L., additional, Umeda, N., additional, Kashiwagi, M., additional, Watanabe, K., additional, Tobari, H., additional, Dairaku, M., additional, Sakamoto, K., additional, Inoue, T., additional, Surrey, Elizabeth, additional, and Simonin, Alain, additional

Published
2009
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160. Spectroscopic observations of beam and source plasma light and testing Cs-deposition monitor in the large area negative ion source for LHD-NBI

Author

Oka, Y., primary, Tsumori, K., additional, Ikeda, K., additional, Kaneko, O., additional, Nagaoka, K., additional, Osakabe, M., additional, Takeiri, Y., additional, Asano, E., additional, Komada, S., additional, Kondo, T., additional, Sato, M., additional, Shibuya, M., additional, Grisham, L. R., additional, Ikeda, Y., additional, Hanada, M., additional, and Umeda, N., additional

Published
2008
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161. 13 POTENTIAL NEGATIVE IMPACT OF AGING ON HEPATOCARCINOGENESIS AFTER ANTI-VIRAL TREATMENT IN PATIENTS WITH CHRONIC HEPATITIS C AND BENEFIT OF VIRAL ERADICATION BY PEG-INTERFRON/RIBAVIRIN TREATMENT

Author

Asahina, Y., primary, Izuni, N., additional, Hirayama, I., additional, Sato, M., additional, Yasui, Y., additional, Tanaka, T., additional, Komatsu, N., additional, Umeda, N., additional, Hosokawa, T., additional, Ueda, K., additional, Tsuchiya, K., additional, Nakanishi, H., additional, Itakura, J., additional, Kurosaki, M., additional, and Miyake, S., additional

Published
2008
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162. 415 ORAL SUPPLEMENTATION WITH BRANCHED-CHAIN AMINO ACIDS (BCAA) IMPROVES SURVIVIAL AND DECREASES THE THIRD TIME RECURRNCE AFTER SUCCESSFUL TREATMENT OF HEPATOCELLULAR CARCINOMA (HCC)

Author

Tsuchiya, K., primary, Asahina, Y., additional, Sato, M., additional, Tanaka, T., additional, Hirayama, I., additional, Yasui, Y., additional, Komatsu, N., additional, Umeda, N., additional, Hosokawa, T., additional, Ueda, K., additional, Nakanishi, H., additional, Itakura, J., additional, Kurosaki, M., additional, and Namiki, I., additional

Published
2008
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172. Specific overexpression of tumour necrosis factor-α-induced protein (TNFAIP)9 in CD14+CD16− monocytes in patients with rheumatoid arthritis: comparative analysis with TNFAIP3.

Author

Takai, C., Matsumoto, I., Inoue, A., Umeda, N., Tanaka, Y., Kurashima, Y., Wada, Y., Narita, I., and Sumida, T.

Subjects
GENETIC overexpression, TUMOR necrosis factors, CD14 antigen, MONOCYTES, RHEUMATOID arthritis, COMPARATIVE studies, PATIENTS
Abstract

The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play an important pathogenic role in murine arthritis. To clarify their pathophysiological roles in patients with rheumatoid arthritis (RA), we examined their expression and localization in peripheral blood mononuclear cells (PBMC). TNFAIP9 and TNFAIP3 mRNA expression was determined in PBMC of RA patients and healthy subjects (control). Flow cytometry was used to analyse the main TNFAIP9- and TNFAIP3-expressing cell populations. TNFAIP9 and TNFAIP3 mRNA expression levels were examined in vitro on CD14+ cells stimulated with TNF-α and lipopolysaccharide (LPS). The expression levels of TNFAIP9 and TNFAIP3 mRNA were also measured before and 12 weeks after treatment with tocilizumab and abatacept. TNFAIP9 expression was significantly higher, while TNFAIP3 expression was lower in PBMC of RA ( n = 36) than the control ( n = 24) (each P < 0·05). TNFAIP9 was expressed on CD14+ cells, especially in human leucocyte antigen D-related (HLA-DR)+CD14brightCD16−cells, while TNFAIP3 was expressed mainly on CD3+ T cells. TNF-α and LPS induced TNFAIP9 and TNFAIP3 in human CD14+monocytes in vitro. Treatment with tocilizumab ( n = 13), but not abatacept ( n = 11), significantly reduced TNFAIP9 mRNA expression in PBMC, which was associated with reduction in the number of circulating CD14bright monocytes. The expression of TNFAIP9 in CD14+ cells was specifically elevated in patients with RA, regulated by TNF-α and LPS, and suppressed by tocilizumab, while TNFAIP3 in PBMC showed different localization and induction patterns. [ABSTRACT FROM AUTHOR]

Published
2015
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173. Predictors of the response to treatment in acute lupus hemophagocytic syndrome.

Author

Takahashi, H, Tsuboi, H, Kurata, I, Inoue, S, Ebe, H, Yokosawa, M, Hagiwara, S, Hirota, T, Asashima, H, Kaneko, S, Kawaguchi, H, Kurashima, Y, Miki, H, Umeda, N, Kondo, Y, Ogishima, H, Suzuki, T, Matsumoto, I, and Sumida, T

Subjects
LUPUS erythematosus, C-reactive protein, HEMOGLOBINS, ADRENOCORTICAL hormones, FERRITIN, PATIENTS, THERAPEUTICS
Abstract

The article focuses on a study which aims to identify predictors for the response to the treatment of acute lupus hemophagocytic syndrome (ALHS). It states that patients treated with cyclosporine A (CsA), serum ferritn was higher in CsA responders. It mentions that low C-reactive protein (CRP) and high hemoglobin can predict positive response to corticosteroid monotherapy while high serum ferritin and low leukocyute count can predict response to CsA in patients with ALHS.

Published
2015
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181. Present status of the negative ion based NBI system for long pulse operation on JT-60U

Author

Ikeda, Y, primary, Umeda, N, additional, Akino, N, additional, Ebisawa, N, additional, Grisham, L, additional, Hanada, M, additional, Honda, A, additional, Inoue, T, additional, Kawai, M, additional, Kazawa, M, additional, Kikuchi, K, additional, Komata, M, additional, Mogaki, K, additional, Noto, K, additional, Okano, F, additional, Ohga, T, additional, Oshima, K, additional, Takenouchi, T, additional, Tanai, Y, additional, Usui, K, additional, Yamazaki, H, additional, and Yamamoto, T, additional

Published
2006
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186. Analysis of electron temperature distribution by Kinetic modeling of electron energy distribution function in JAEA 10 ampere negative ion source.

Author

Shibata, T., Terasaki, R., Kashiwagi, M., Inoue, T., Dairaku, M., Taniguchi, M., Tobari, H., Umeda, N., Watanabe, K., Sakamto, K., and Hatayama, A.

Subjects
ELECTRON temperature, KINETIC energy, ION sources, NEUTRAL beams, ION bombardment, ELECTRON distribution
Abstract

In large negative ion sources of the neutral beam injector (NBI) for large fusion devices, such as ITER and JT-60SA, one of issues is that negative ion beam might be partially intercepted at acceleration grids due to a spatial non-uniformity of negative ion production on large extraction area. Previous experiments have shown that fast electrons emitted from filament cathodes are transported in a longitudinal direction by B × grad B drift and the spatial distribution of electron temperature (Te) is strongly related with the non-uniformity of negative ion production. In this study, a three-dimensional electron transport analysis code including detailed collision processes has been developed to clarify a physical mechanism of non-uniform Te distribution. Electron density and temperature in the analysis agree well with measurements by Langmuir probe in the JAEA 10A ion source. Then, this study has clarified that the non-uniformity of Te distribution is mainly caused by the following reasons; i) fast electrons drifted in the longitudinal direction survive near the end wall with high energy up to E = 25 - 60 eV and ii) they produce thermal electrons by collision with plasma particles there. [ABSTRACT FROM AUTHOR]

Published
2013
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187. Recent Activities of Negative Ion Based NBI System on JT-60U

Author

Ebisawa, N., primary, Akino, N., additional, Grisham, L., additional, Hanada, M., additional, Honda, A., additional, Inoue, T., additional, Kawai, M., additional, Kazawa, M., additional, Kikuchi, K., additional, Komata, M., additional, Mogaki, K., additional, Noto, K., additional, Okano, F., additional, Ohga, T., additional, Oshima, K., additional, Takenouchi, T., additional, Tanai, Y., additional, Umeda, N., additional, Usui, K., additional, Yamazaki, H., additional, Yamamoto, T., additional, and Ikeda, Y., additional

Published
2005
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191. Long Pulse Operation on NBI Systems for JT-60U

Author

Akino, N., primary, Ebisawa, N., additional, Honda, A., additional, Ikeda, Y., additional, Kawai, M., additional, Kazawa, M., additional, Mogaki, K., additional, Ohga, T., additional, Umeda, N., additional, Usui, K., additional, Yamamoto, T., additional, and Grisham, L., additional

Published
2005
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196. Acceleration of 500 keV Negative Ion Beams By Tuning Vacuum Insulation Distance On JT-60 Negative Ion Source.

Author

Kojima, A., Hanada, M., Tanaka, Y., Taniguchi, M., Kashiwagi, M., Inoue, T., Umeda, N., Watanabe, K., Tobari, H., Kobayashi, S., Yamano, Y., and Grisham, L. R.

Subjects
ION bombardment, ION sources, VACUUM, ANIONS, ION accelerators, ELECTRIC fields, RADIATION shielding
Abstract

Acceleration of a 500 keV beam up to 2.8 A has been achieved on a JT-60U negative ion source with a three-stage accelerator by overcoming low voltage holding which is one of the critical issues for realization of the JT-60SA ion source. In order to improve the voltage holding, preliminary voltage holding tests with small-size grids with uniform and locally intense electric fields were carried out, and suggested that the voltage holding was degraded by both the size and local electric field effects. Therefore, the local electric field was reduced by tuning gap lengths between the large size grids and grid support structures of the accelerator. Moreover, a beam radiation shield which limited extension of the minimum gap length was also optimized so as to reduce the local electric field while maintaining the shielding effect. These modifications were based on the experiment results, and significantly increased the voltage holding from <150 kV/stage for the original configuration to 200 kV/stage. These techniques for improvement of voltage holding should also be applicable to other large ion sources accelerators such as those for ITER. [ABSTRACT FROM AUTHOR]

Published
2011
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197. Improvement of voltage holding and high current beam acceleration by MeV accelerator for ITER NB.

Author

Taniguchi, M., Kashiwagi, M., Inoue, T., Umeda, N., Watanabe, K., Tobari, H., Dairaku, M., Yamanaka, H., Tsuchida, K., Kojima, A., Hanada, M., and Sakamoto, K.

Subjects
ION accelerators, ION bombardment, ANIONS, ELECTRIC potential, ELECTRIC currents, ELECTRODES, ELECTRIC fields
Abstract

Voltage holding of -1 MV is an essential issue in development of a multi-aperture multi-grid (MAMuG) negative ion accelerator, of which target is to accelerate 200 A/m2 H- ion beam up to the energy of 1 MeV for several tens seconds. Review of voltage holding results ever obtained with various geometries of the accelerators showed that the voltage holding capability was about a half of designed value based on the experiment obtained from ideal small electrode. This is considered due to local electric field concentration in the accelerators, such as edge and steps between multi-aperture grids and its support structures. Based on the detailed investigation with electric field analysis, accelerator was modified to reduce the electric field concentration by reshaping the support structures and expanding the gap length between the grid supports. After the modifications, the accelerator succeeded in sustaining -1 MV for more than one hour in vacuum. Improvement of the voltage holding characteristics progressed the energy and current accelerated by the MeV accelerator. Up to 2010, beam parameters achieved by the MAMuG accelerator were increased to 879 keV, 0.36 A (157 A/m2) at perveance matched condition and 937 keV, 0.33 A (144 A/m2) slightly under perveance. [ABSTRACT FROM AUTHOR]

Published
2011
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198. Development of the JT-60SA Neutral Beam Injectors.

Author

Hanada, M., Kojima, A., Inoue, T., Watanabe, K., Taniguchi, M., Kashiwagi, M., Tobari, H., Umeda, N., Akino, N., Kazawa, M., Oasa, K., Komata, M., Usui, K., Mogaki, K., Sasaki, S., Kikuchi, K., Nemoto, S., Ohshima, K., Endo, Y., and Simizu, T.

Subjects
NEUTRAL beams, ION sources, INJECTORS, ELECTRIC potential, ION bombardment, VACUUM, MAGNETIC shielding
Abstract

This paper describes the development of the neutral beam (NB) systems on JT-60SA, where 30-34 MW D0 beams are required to be injected for 100 s. A 30 s operation of the NB injectors suggests that existing beamline components and positive ion sources on JT-60U can be reused without the modifications on JT-60 SA. The JT-60 negative ion source was modified to improve the voltage holding capability, which leads to a successful acceleration of 2.8 A H- ion beam up to 500 keV of the rated acceleration energy for JT-60SA. [ABSTRACT FROM AUTHOR]

Published
2011
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200. Achievement of high fusion triple product, steady-state sustainment and real-time NTM stabilization in high- pELMy H-mode discharges in JT-60U

Author

Isayama, A, primary, Kamada, Y, additional, Hayashi, N, additional, Suzuki, T, additional, Oikawa, T, additional, Fujita, T, additional, Fukuda, T, additional, Ide, S, additional, Takenaga, H, additional, Ushigusa, K, additional, Ozeki, T, additional, Ikeda, Y, additional, Umeda, N, additional, Yamada, H, additional, Isobe, M, additional, Narushima, Y, additional, Ikeda, K, additional, Sakakibara, S, additional, Yamazaki, K, additional, Nagasaki, K, additional, and Team, the JT-60, additional

Published
2003
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